diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 96aa5a1d..e7bfab3c 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -19,7 +19,7 @@ jobs:
     steps:
     - uses: actions/checkout@v4
 
-# build the doxygen XML for breathe
+    # build the doxygen XML for breathe
     - name: Checkout openchemistry
       uses: actions/checkout@v4
       with:
@@ -38,9 +38,16 @@ jobs:
         sudo apt-get -qq update
         sudo apt-get -qq install doxygen ninja-build libeigen3-dev libglew-dev libxml2-dev qtbase5-dev qtchooser qt5-qmake qtbase5-dev-tools libqt5x11extras5-dev libqt5svg5-dev
 
+    - name: Install uv
+      uses: astral-sh/setup-uv@v2
+    
+    - name: "Set up Python"
+      uses: actions/setup-python@v5
+      with:
+        python-version-file: ".python-version"
+
     - name: Install Sphinx and requirements
-      run: |
-        pip install -U sphinx myst-parser breathe pydata-sphinx-theme sphinxext-rediraffe sphinx-design sphinx-copybutton linkify-it-py pygments
+      run: uv pip install --system --break-system-packages -r pyproject.toml
 
     - name: Configure
       run: |
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 00000000..b961080b
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,17 @@
+[project]
+name = "two-avogadro-cc"
+version = "2.dev0"
+description = "Documentation and development website for Avogadro2"
+readme = "README.md"
+requires-python = ">=3.11"
+dependencies = [
+    "breathe>=4.35.0",
+    "linkify-it-py>=2.0.3",
+    "myst-parser>=4.0.0",
+    "pydata-sphinx-theme>=0.15.4",
+    "sphinx>=8.0.2",
+    "sphinx-copybutton>=0.5.2",
+    "sphinx-design>=0.6.1",
+    "sphinxext-rediraffe>=0.2.7",
+    "sphinx-togglebutton>=0.3.2",
+]
diff --git a/source/requirements.txt b/source/requirements.txt
deleted file mode 100644
index 330115c8..00000000
--- a/source/requirements.txt
+++ /dev/null
@@ -1,8 +0,0 @@
-sphinx
-myst-parser
-breathe
-pydata-sphinx-theme
-sphinx-design
-sphinx-copybutton
-linkify-it-py
-sphinxext.rediraffe