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The ADReCS severity-grading model consists of three steps:

  • Step1: Input ADR reports data.
  • Step2: Calculate ADR Severity_score.
  • Step3: ADR Severity Grading.

Input files: report_data.txt and drug_adr_ROR.txt.

  1. The report_data.txt needs four columns:
    • substance_name: drug name.
    • pt_term: ADR term.
    • report_source: adverse event reports ID (custom ID used for unique identification of reports).
    • reaction_outcome: outcome of the reaction in FAERS.
  2. The drug_adr_ROR.txt needs three columns:
    • substance_name: drug name.
    • pt_term: ADR term.
    • drug_adr_pair_ROR: The reporting odds ratio (ROR) for ADR induced by Drug was calculated based on the two-by-two contingency table.