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[Feature Request] Modules eigenvector determination #40

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bvenn opened this issue Oct 15, 2021 · 0 comments
Open

[Feature Request] Modules eigenvector determination #40

bvenn opened this issue Oct 15, 2021 · 0 comments
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@bvenn
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bvenn commented Oct 15, 2021

After network modules are identified the 'average signal profile' can be identified by calculating the modules eigengene. It would be a handy addition to investigate the structure of module.

Specifically, we define the module eigengene as the first right-singular vector of the standardized module expression data (Methods, Eq. 29). - Langfelder and Horvath, 2007, BMC

Notes:

  • A singular value decomposition is required. Whether a statistics library depedency makes sense is open to debate.
  • A standardization may be necessary.
  • After that, the eigengene may need to be inverted, depending on the correlations of most of the elements in it.
    • The orientation of the eigengene is solely determined by the orientation of the first row of the matrix
@LibraChris LibraChris added this to the Backlog milestone Apr 16, 2023
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