diff --git a/Tappas.java b/Tappas.java
index a7ad567..8babb70 100644
--- a/Tappas.java
+++ b/Tappas.java
@@ -37,7 +37,7 @@ public class Tappas extends Application {
// otherwise, it will just inform the user that the app is already running
// WARNING: if the app shutdowns w/o deleting file,
// it is possible that a different app is now using the port
- // May want to deal with it later if we stick to this locking approach
+ // May want to deaTo cite us visit: l with it later if we stick to this locking approach
// In unix/linux/mac, can execute script and use netstat for port and then ps to get the process
// b) If file not found, will look for a port to lock and create
// a lock file to save the number - when exiting, the app will delete the file
@@ -51,11 +51,11 @@ public class Tappas extends Application {
public static final String APP_NAME = "tappas";
public static final int APP_MAJOR_VER = 1;
public static final int APP_MINOR_VER = 0;
- public static final int APP_STRREV = 1;
+ public static final int APP_STRREV = 2;
public static final String RES_VER_FILE = "resource_v" + APP_MAJOR_VER + "." + APP_MINOR_VER + "." + APP_STRREV + ".txt";
public static final String APP_LOCK_FILE = ".tappas.lock.prm";
public static final String APP_PORT_PARAM = "port";
- public static final String APP_STRVER = APP_MAJOR_VER + "." + String.format("%02d", APP_MINOR_VER) + "." + String.format("%02d", APP_STRREV);
+ public static final String APP_STRVER = APP_MAJOR_VER + "." + String.format("%01d", APP_MINOR_VER) + "." + String.format("%01d", APP_STRREV);
public static final double APP_VER = APP_MAJOR_VER + (APP_MINOR_VER/100.0);
public boolean havePackages = false;
private static final App app = new App();
diff --git a/resources/go.obo b/resources/go.obo
index 05f1730..fb9bb45 100644
--- a/resources/go.obo
+++ b/resources/go.obo
@@ -1,5 +1,6 @@
format-version: 1.2
-data-version: releases/2020-05-02
+data-version: releases/2020-07-16
+subsetdef: chebi_ph7_3 "Rhea list of ChEBI terms representing the major species at pH 7.3."
subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation"
subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation"
subsetdef: goslim_agr "AGR slim"
@@ -588,14 +589,11 @@ is_obsolete: true
id: GO:0000062
name: fatty-acyl-CoA binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
-synonym: "acyl-CoA or acyl binding" BROAD []
-is_a: GO:0032559 ! adenyl ribonucleotide binding
-is_a: GO:0033218 ! amide binding
-is_a: GO:0043168 ! anion binding
-is_a: GO:0050662 ! coenzyme binding
+def: "Interacting selectively and non-covalently with a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]
+synonym: "fatty-acyl binding" BROAD []
+synonym: "fatty-acyl-coenzyme A binding" EXACT []
+is_a: GO:0120227 ! acyl-CoA binding
is_a: GO:1901567 ! fatty acid derivative binding
-is_a: GO:1901681 ! sulfur compound binding
[Term]
id: GO:0000064
@@ -881,7 +879,6 @@ synonym: "S-adenosylmethionine transmembrane transporter activity" EXACT []
synonym: "S-adenosylmethionine transporter activity" BROAD []
synonym: "SAM transmembrane transporter activity" EXACT []
xref: Reactome:R-HSA-8855062 "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy"
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:1901962 ! S-adenosyl-L-methionine transmembrane transport
@@ -1341,7 +1338,7 @@ synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1
synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101]
xref: EC:1.1.1.101
xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN
-xref: Reactome:R-HSA-75883 "O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+"
+xref: Reactome:R-HSA-75883 "DHRS7B reduces GO3P to HXDG3P"
xref: RHEA:17341
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -1419,7 +1416,7 @@ def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylma
subset: goslim_chembl
synonym: "SNAP receptor binding" EXACT []
xref: Reactome:R-HSA-210426 "Glutamate synaptic vesicle docking and priming"
-xref: Reactome:R-HSA-210430 "release of L-Glutamate at the synapse"
+xref: Reactome:R-HSA-210430 "Release of L-Glutamate at the synapse"
xref: Reactome:R-HSA-265166 "Exocytosis of Insulin"
xref: Reactome:R-HSA-372505 "Acetylcholine synaptic vesicle docking and priming"
xref: Reactome:R-HSA-372529 "Release of acetylcholine at the synapse"
@@ -1701,9 +1698,9 @@ def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' ter
synonym: "3'-5' exoribonuclease activity" EXACT []
xref: EC:3.1.13
xref: Reactome:R-HSA-430028 "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion"
-xref: Reactome:R-HSA-6791218 "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA"
xref: Reactome:R-HSA-6791222 "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA"
xref: Reactome:R-HSA-6791227 "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA"
+xref: Reactome:R-HSA-9682603 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA"
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters
@@ -2178,6 +2175,7 @@ synonym: "Tpt1p" RELATED [EC:2.7.1.160]
synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160]
xref: EC:2.7.1.160
xref: MetaCyc:2.7.1.160-RXN
+xref: RHEA:23324
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -2664,7 +2662,6 @@ name: allantoin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684]
synonym: "allantoin metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -2679,7 +2676,6 @@ synonym: "allantoin breakdown" EXACT []
synonym: "allantoin catabolism" EXACT []
synonym: "allantoin degradation" EXACT []
is_a: GO:0000255 ! allantoin metabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -2920,6 +2916,7 @@ synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase ac
synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59]
xref: EC:2.1.1.59
xref: MetaCyc:2.1.1.59-RXN
+xref: RHEA:24312
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
[Term]
@@ -3145,7 +3142,6 @@ namespace: biological_process
def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732]
is_a: GO:0006812 ! cation transport
is_a: GO:0015846 ! polyamine transport
-is_a: GO:0015893 ! drug transport
[Term]
id: GO:0000297
@@ -3168,6 +3164,7 @@ synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10]
synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10]
xref: EC:3.6.1.10
xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN
+xref: RHEA:22452
is_a: GO:0016462 ! pyrophosphatase activity
[Term]
@@ -3225,9 +3222,7 @@ name: response to singlet oxygen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732]
is_a: GO:0000302 ! response to reactive oxygen species
-is_a: GO:0007584 ! response to nutrient
is_a: GO:0010035 ! response to inorganic substance
-is_a: GO:0042493 ! response to drug
[Term]
id: GO:0000305
@@ -3488,7 +3483,7 @@ relationship: part_of GO:0062159 ! contractile vacuole complex
id: GO:0000332
name: template for synthesis of G-rich strand of telomere DNA activity
namespace: molecular_function
-def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242]
+def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242, PMID:7958872]
comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins.
synonym: "telomerase RNA" EXACT []
synonym: "telomerase, template" EXACT []
@@ -4891,6 +4886,7 @@ def: "Interacting selectively and non-covalently with nucleic acid via hydrogen
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
synonym: "base pairing with DNA" RELATED []
is_a: GO:0003677 ! DNA binding
+is_a: GO:0140489 ! molecular template activity
[Term]
id: GO:0000500
@@ -5726,6 +5722,7 @@ synonym: "PLMT" EXACT []
synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71]
xref: EC:2.1.1.71
xref: MetaCyc:2.1.1.71-RXN
+xref: RHEA:32735
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
@@ -6119,6 +6116,7 @@ synonym: "DGPP phosphohydrolase activity" EXACT []
synonym: "diacylglycerol pyrophosphate phosphatase activity" EXACT []
xref: EC:3.1.3.81
xref: MetaCyc:RXN-11277
+xref: RHEA:27449
is_a: GO:0016462 ! pyrophosphatase activity
[Term]
@@ -6227,7 +6225,6 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators]
synonym: "InsP6 binding" EXACT []
synonym: "IP6 binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding
@@ -6256,6 +6253,7 @@ synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT []
synonym: "inositol polyphosphate multikinase activity" BROAD []
synonym: "IpmK" BROAD []
xref: Reactome:R-HSA-1855185 "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus"
+xref: RHEA:11856
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity
[Term]
@@ -6285,7 +6283,7 @@ id: GO:0000827
name: inositol-1,3,4,5,6-pentakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown." [GOC:elh, PMID:11311242]
-synonym: "EC:2.7.4.21" BROAD []
+xref: EC:2.7.4.21
xref: Reactome:R-HSA-1855181 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus"
xref: Reactome:R-HSA-1855223 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol"
is_a: GO:0016301 ! kinase activity
@@ -6475,6 +6473,7 @@ def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-
synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX]
xref: EC:2.5.1.78
xref: MetaCyc:LUMAZINESYN-RXN
+xref: RHEA:26152
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
[Term]
@@ -6776,13 +6775,17 @@ is_a: GO:0030428 ! cell septum
id: GO:0000935
name: division septum
namespace: cellular_component
+alt_id: GO:0043187
def: "A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt, GOC:vw]
+synonym: "cell septum surface" RELATED []
synonym: "complete septum" EXACT []
synonym: "divison septum" EXACT []
+synonym: "septum surface" BROAD []
is_a: GO:0030428 ! cell septum
intersection_of: GO:0030428 ! cell septum
intersection_of: part_of GO:0032153 ! cell division site
relationship: part_of GO:0032153 ! cell division site
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19434 xsd:anyURI
[Term]
id: GO:0000936
@@ -6932,7 +6935,6 @@ def: "The chemical reactions and pathways involving the catabolism of amino acid
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0009087 ! methionine catabolic process
-is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
[Term]
@@ -7200,7 +7202,7 @@ alt_id: GO:0001201
alt_id: GO:0001202
alt_id: GO:0001203
alt_id: GO:0003705
-def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018]
+def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018]
synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW []
synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW []
synonym: "metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW []
@@ -9108,7 +9110,7 @@ name: DNA-binding transcription activator activity
namespace: molecular_function
alt_id: GO:0001140
alt_id: GO:0001215
-def: "Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase." [GOC:krc]
+def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase." [GOC:txnOH-2018]
synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" RELATED []
synonym: "bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW []
synonym: "bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding" NARROW []
@@ -9131,7 +9133,7 @@ alt_id: GO:0001141
alt_id: GO:0001218
alt_id: GO:0001219
alt_id: GO:0001220
-def: "Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase." [GOC:krc]
+def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase." [GOC:txnOH-2018]
synonym: "bacterial-type DNA binding transcription repressor activity" NARROW []
synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding" NARROW []
@@ -9214,7 +9216,7 @@ alt_id: GO:0001078
alt_id: GO:0001206
alt_id: GO:0001210
alt_id: GO:0001214
-def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018]
+def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018]
synonym: "distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW []
synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW []
synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW []
@@ -9248,7 +9250,7 @@ alt_id: GO:0001209
alt_id: GO:0001211
alt_id: GO:0001212
alt_id: GO:0001213
-def: "A protein, or a member of a complex, or a non-coding RNA that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
+def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]
synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW []
synonym: "distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW []
synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW []
@@ -9805,8 +9807,6 @@ synonym: "phaseolin activity" RELATED [EC:3.4.22.34]
synonym: "proteinase B" RELATED [EC:3.4.22.34]
synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34]
synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34]
-xref: EC:3.4.22.34
-xref: MetaCyc:3.4.22.34-RXN
is_obsolete: true
replaced_by: GO:0004197
@@ -9848,6 +9848,7 @@ synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT []
xref: EC:1.10.99.2
xref: MetaCyc:1.10.99.2-RXN
xref: Reactome:R-HSA-8936519 "NQO2:FAD dimer reduces quinones to hydroquinones"
+xref: RHEA:12364
is_a: GO:0016491 ! oxidoreductase activity
[Term]
@@ -11189,6 +11190,7 @@ xref: EC:2.4.99.3
xref: MetaCyc:2.4.99.3-RXN
xref: Reactome:R-HSA-4084980 "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)"
xref: Reactome:R-HSA-9603991 "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG"
+xref: RHEA:11136
is_a: GO:0008373 ! sialyltransferase activity
[Term]
@@ -11455,7 +11457,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
-is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
@@ -11472,7 +11473,6 @@ synonym: "histamine synthesis" EXACT []
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
-is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
@@ -11745,6 +11745,7 @@ def: "Projection at the leading edge of a crawling cell; the protrusions are sup
synonym: "membrane ruffle" RELATED []
is_a: GO:0120025 ! plasma membrane bounded cell projection
relationship: part_of GO:0031252 ! cell leading edge
+property_value: RO:0002161 NCBITaxon:4890
[Term]
id: GO:0001727
@@ -11782,6 +11783,7 @@ xref: MetaCyc:RXN-13648
xref: Reactome:R-HSA-8983680 "OAS1 produces oligoadenylates"
xref: Reactome:R-HSA-8985091 "OAS3 produces oligoadenylates"
xref: Reactome:R-HSA-8985104 "OAS2 produces oligoadenylates"
+xref: RHEA:34407
is_a: GO:0070566 ! adenylyltransferase activity
[Term]
@@ -12076,7 +12078,6 @@ name: beta-alanine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd]
synonym: "beta-alanine transporter activity" BROAD []
-is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
relationship: part_of GO:0001762 ! beta-alanine transport
@@ -12085,7 +12086,6 @@ id: GO:0001762
name: beta-alanine transport
namespace: biological_process
def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd]
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0015804 ! neutral amino acid transport
[Term]
@@ -13537,7 +13537,7 @@ name: regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0001897 ! cytolysis by symbiont of host cells
@@ -14116,7 +14116,7 @@ namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]
synonym: "vascular system development" RELATED []
is_a: GO:0048731 ! system development
-relationship: part_of GO:0072358 ! cardiovascular system development
+relationship: part_of GO:0072359 ! circulatory system development
[Term]
id: GO:0001945
@@ -14470,10 +14470,7 @@ id: GO:0001975
name: response to amphetamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:dph, GOC:ef]
-is_a: GO:0009410 ! response to xenobiotic stimulus
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0014075 ! response to amine
-is_a: GO:0097366 ! response to bronchodilator
[Term]
id: GO:0001976
@@ -15098,8 +15095,6 @@ synonym: "regulation of L-glutamate import" BROAD []
synonym: "regulation of L-glutamate transport" BROAD []
synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
-is_a: GO:0051580 ! regulation of neurotransmitter uptake
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0098712 ! L-glutamate import across plasma membrane
relationship: regulates GO:0098712 ! L-glutamate import across plasma membrane
@@ -15129,10 +15124,8 @@ synonym: "negative regulation of L-glutamate transport" BROAD []
synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie]
synonym: "regulation of L-glutamate import" BROAD []
is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane
-is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane
relationship: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane
@@ -15162,10 +15155,8 @@ synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie]
synonym: "upregulation of L-glutamate transport" BROAD []
synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie]
is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane
-is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane
relationship: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane
@@ -15363,7 +15354,6 @@ name: uracil binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with uracil." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine nucleobase binding
-is_a: GO:0008144 ! drug binding
[Term]
id: GO:0002059
@@ -15570,6 +15560,7 @@ def: "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxyben
xref: EC:2.5.1.39
xref: MetaCyc:RXN-9230
xref: Reactome:R-HSA-2162192 "PHB and all-E-10PrP2 are combined into DHB by COQ2"
+xref: RHEA:44564
is_a: GO:0002094 ! polyprenyltransferase activity
[Term]
@@ -16125,6 +16116,7 @@ def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyro
synonym: "HMP-PP diphosphatase" EXACT []
synonym: "HMP-PP pyrophosphatase" EXACT []
xref: MetaCyc:RXN0-3543
+xref: RHEA:27914
is_a: GO:0016462 ! pyrophosphatase activity
created_by: hjd
creation_date: 2009-06-10T11:21:35Z
@@ -18691,7 +18683,6 @@ namespace: biological_process
def: "The regulated release of platelet activating factor by a cell." [GOC:add, ISBN:0781735149]
is_a: GO:0010876 ! lipid localization
is_a: GO:0015697 ! quaternary ammonium group transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0050663 ! cytokine secretion
is_a: GO:0140353 ! lipid export from cell
@@ -20193,7 +20184,7 @@ namespace: biological_process
def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by mast cell" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
-is_a: GO:0046907 ! intracellular transport
+is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0043303 ! mast cell degranulation
@@ -20203,7 +20194,7 @@ name: histamine secretion by mast cell
namespace: biological_process
def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
-is_a: GO:0046907 ! intracellular transport
+is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0140029 ! exocytic process
relationship: part_of GO:0043303 ! mast cell degranulation
@@ -22514,8 +22505,12 @@ relationship: positively_regulates GO:0002228 ! natural killer cell mediated imm
id: GO:0002718
name: regulation of cytokine production involved in immune response
namespace: biological_process
+alt_id: GO:0002739
+alt_id: GO:0002742
def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
+synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph]
+synonym: "regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0050776 ! regulation of immune response
@@ -22527,12 +22522,16 @@ relationship: regulates GO:0002367 ! cytokine production involved in immune resp
id: GO:0002719
name: negative regulation of cytokine production involved in immune response
namespace: biological_process
+alt_id: GO:0002740
+alt_id: GO:0002743
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine production during immune response" RELATED []
synonym: "down-regulation of cytokine production during immune response" EXACT []
synonym: "downregulation of cytokine production during immune response" RELATED []
synonym: "inhibition of cytokine production during immune response" RELATED []
+synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph]
+synonym: "negative regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
@@ -22545,9 +22544,13 @@ relationship: negatively_regulates GO:0002367 ! cytokine production involved in
id: GO:0002720
name: positive regulation of cytokine production involved in immune response
namespace: biological_process
+alt_id: GO:0002741
+alt_id: GO:0002744
def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "activation of cytokine production during immune response" NARROW []
+synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph]
+synonym: "positive regulation of cytokine secretion involved in immune response" NARROW []
synonym: "stimulation of cytokine production during immune response" NARROW []
synonym: "up regulation of cytokine production during immune response" RELATED []
synonym: "up-regulation of cytokine production during immune response" RELATED []
@@ -22843,100 +22846,6 @@ intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production
relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production
-[Term]
-id: GO:0002739
-name: regulation of cytokine secretion involved in immune response
-namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]
-synonym: "regulation of cytokine secretion during immune response" RELATED [GOC:dph]
-is_a: GO:0002718 ! regulation of cytokine production involved in immune response
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0002374 ! cytokine secretion involved in immune response
-relationship: regulates GO:0002374 ! cytokine secretion involved in immune response
-
-[Term]
-id: GO:0002740
-name: negative regulation of cytokine secretion involved in immune response
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]
-synonym: "down regulation of cytokine secretion during immune response" RELATED []
-synonym: "down-regulation of cytokine secretion during immune response" RELATED []
-synonym: "downregulation of cytokine secretion during immune response" RELATED []
-synonym: "inhibition of cytokine secretion during immune response" NARROW []
-synonym: "negative regulation of cytokine secretion during immune response" RELATED [GOC:dph]
-is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
-is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response
-relationship: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response
-
-[Term]
-id: GO:0002741
-name: positive regulation of cytokine secretion involved in immune response
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]
-synonym: "activation of cytokine secretion during immune response" NARROW []
-synonym: "positive regulation of cytokine secretion during immune response" RELATED [GOC:dph]
-synonym: "stimulation of cytokine secretion during immune response" NARROW []
-synonym: "up regulation of cytokine secretion during immune response" RELATED []
-synonym: "up-regulation of cytokine secretion during immune response" RELATED []
-synonym: "upregulation of cytokine secretion during immune response" RELATED []
-is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
-is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0002374 ! cytokine secretion involved in immune response
-relationship: positively_regulates GO:0002374 ! cytokine secretion involved in immune response
-
-[Term]
-id: GO:0002742
-name: regulation of cytokine biosynthetic process involved in immune response
-namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add]
-synonym: "regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph]
-is_a: GO:0002718 ! regulation of cytokine production involved in immune response
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
-relationship: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
-
-[Term]
-id: GO:0002743
-name: negative regulation of cytokine biosynthetic process involved in immune response
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add]
-synonym: "down regulation of cytokine biosynthetic process during immune response" RELATED []
-synonym: "down-regulation of cytokine biosynthetic process during immune response" RELATED []
-synonym: "downregulation of cytokine biosynthetic process during immune response" RELATED []
-synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW []
-synonym: "negative regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph]
-is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
-is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
-relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
-
-[Term]
-id: GO:0002744
-name: positive regulation of cytokine biosynthetic process involved in immune response
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add]
-synonym: "activation of cytokine biosynthetic process during immune response" NARROW []
-synonym: "positive regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph]
-synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW []
-synonym: "up regulation of cytokine biosynthetic process during immune response" RELATED []
-synonym: "up-regulation of cytokine biosynthetic process during immune response" RELATED []
-synonym: "upregulation of cytokine biosynthetic process during immune response" RELATED []
-is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
-is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
-relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
-
[Term]
id: GO:0002745
name: antigen processing and presentation initiated by receptor mediated uptake of antigen
@@ -25491,7 +25400,6 @@ id: GO:0002936
name: bradykinin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin." [PMID:11226291]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0043043 ! peptide biosynthetic process
created_by: hjd
creation_date: 2012-10-17T14:24:24Z
@@ -25611,6 +25519,7 @@ def: "Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA
synonym: "ArcS" RELATED []
synonym: "glutamine:preQ0-tRNA amidinotransferase" RELATED []
xref: EC:2.6.1.97
+xref: RHEA:54084
is_a: GO:0015067 ! amidinotransferase activity
created_by: hjd
creation_date: 2014-08-11T10:33:59Z
@@ -26164,14 +26073,15 @@ is_a: GO:0003053 ! circadian regulation of heart rate
[Term]
id: GO:0003056
-name: regulation of vascular smooth muscle contraction
+name: regulation of vascular associated smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl]
+synonym: "regulation of vascular smooth muscle contraction" EXACT []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0019229 ! regulation of vasoconstriction
intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0014829 ! vascular smooth muscle contraction
-relationship: regulates GO:0014829 ! vascular smooth muscle contraction
+intersection_of: regulates GO:0014829 ! vascular associated smooth muscle contraction
+relationship: regulates GO:0014829 ! vascular associated smooth muscle contraction
[Term]
id: GO:0003057
@@ -30375,6 +30285,7 @@ alt_id: GO:0004003
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.4.12, GOC:jl]
synonym: "ATP-dependent DNA helicase activity" EXACT []
xref: EC:3.6.4.12
+xref: Reactome:R-HSA-5693589 "D-loop dissociation and strand annealing"
is_a: GO:0004386 ! helicase activity
is_a: GO:0008094 ! DNA-dependent ATPase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA
@@ -30382,11 +30293,14 @@ relationship: part_of GO:0032508 ! DNA duplex unwinding
[Term]
id: GO:0003680
-name: AT DNA binding
+name: minor groove of adenine-thymine-rich DNA binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564]
+def: "Interacting selectively and non-covalently with the structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins." [GOC:jl, PMID:10545119, PMID:15802641, PMID:26223912, PMID:2670564]
synonym: "AT binding" EXACT []
-is_a: GO:1990837 ! sequence-specific double-stranded DNA binding
+synonym: "AT DNA binding" EXACT []
+synonym: "AT-rich DNA binding" EXACT []
+is_a: GO:0000217 ! DNA secondary structure binding
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19695 xsd:anyURI
[Term]
id: GO:0003681
@@ -30476,6 +30390,7 @@ def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the openi
synonym: "DNA clamp loading ATPase activity" EXACT []
synonym: "PCNA loading activity" NARROW []
synonym: "PCNA loading complex activity" NARROW []
+xref: Reactome:R-HSA-174439 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:R-HSA-176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
is_a: GO:0003677 ! DNA binding
is_a: GO:0033170 ! protein-DNA loading ATPase activity
@@ -30563,7 +30478,7 @@ alt_id: GO:0001131
alt_id: GO:0001151
alt_id: GO:0001199
alt_id: GO:0001204
-def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]
+def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]
comment: Curator guidance: Note that most DNA-binding transcription factors do not have enzymatic activity. The presence of specific domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing Myb/SANT and ARID domains, since only a subset of proteins containing these domains are DNA-binding transcription factors for specific genes.
subset: goslim_agr
subset: goslim_aspergillus
@@ -31040,6 +30955,7 @@ xref: EC:5.2.1.8
xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
xref: Reactome:R-HSA-2022073 "Procollagen triple helix formation"
xref: Reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1"
+xref: RHEA:16237
is_a: GO:0016859 ! cis-trans isomerase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
relationship: part_of GO:0000413 ! protein peptidyl-prolyl isomerization
@@ -31460,8 +31376,6 @@ synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21]
synonym: "blood coagulation factor VII activity" EXACT []
synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21]
synonym: "coagulation factor VIIa activity" EXACT []
-xref: EC:3.4.21.21
-xref: MetaCyc:3.4.21.21-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31480,8 +31394,6 @@ synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22]
synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22]
synonym: "Christmas factor activity" EXACT [EC:3.4.21.22]
synonym: "coagulation factor IXa activity" EXACT []
-xref: EC:3.4.21.22
-xref: MetaCyc:3.4.21.22-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31505,8 +31417,6 @@ synonym: "Stuart factor" RELATED [EC:3.4.21.6]
synonym: "Stuart factor activity" EXACT [EC:3.4.21.6]
synonym: "thrombokinase activity" EXACT [EC:3.4.21.6]
synonym: "thromboplastin" RELATED [EC:3.4.21.6]
-xref: EC:3.4.21.6
-xref: MetaCyc:3.4.21.6-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31522,8 +31432,6 @@ synonym: "blood coagulation factor XI activity" EXACT []
synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27]
synonym: "coagulation factor XIa activity" EXACT []
synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27]
-xref: EC:3.4.21.27
-xref: MetaCyc:3.4.21.27-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31545,8 +31453,6 @@ synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38]
synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38]
synonym: "prealbumin activator" RELATED [EC:3.4.21.38]
synonym: "prekallikrein activator" RELATED [EC:3.4.21.38]
-xref: EC:3.4.21.38
-xref: MetaCyc:3.4.21.38-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31575,8 +31481,6 @@ synonym: "plasma kallikrein activity" EXACT []
synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34]
synonym: "urinary kallikrein" RELATED [EC:3.4.21.34]
synonym: "urokallikrein" RELATED [EC:3.4.21.34]
-xref: EC:3.4.21.34
-xref: MetaCyc:3.4.21.34-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31594,8 +31498,6 @@ synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69]
synonym: "GSAPC" RELATED [EC:3.4.21.69]
synonym: "protein C (activated) activity" EXACT []
synonym: "protein Ca" RELATED [EC:3.4.21.69]
-xref: EC:3.4.21.69
-xref: MetaCyc:3.4.21.69-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31618,8 +31520,6 @@ synonym: "thrombin-C" RELATED [EC:3.4.21.5]
synonym: "thrombofort" RELATED [EC:3.4.21.5]
synonym: "topical" RELATED [EC:3.4.21.5]
synonym: "tropostasin" RELATED [EC:3.4.21.5]
-xref: EC:3.4.21.5
-xref: MetaCyc:3.4.21.5-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31643,6 +31543,7 @@ xref: MetaCyc:2.3.2.13-RXN
xref: Reactome:R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+"
xref: Reactome:R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking"
xref: RESID:AA0124
+xref: RHEA:54816
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
[Term]
@@ -31678,8 +31579,6 @@ synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47]
synonym: "heat-labile factor" RELATED [EC:3.4.21.47]
synonym: "proenzyme factor B" EXACT []
synonym: "properdin factor B activity" EXACT [EC:3.4.21.47]
-xref: EC:3.4.21.47
-xref: MetaCyc:3.4.21.47-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31699,8 +31598,6 @@ synonym: "classical-complement-pathway C3/C5 convertase activity" EXACT []
synonym: "complement C2 activity" BROAD [EC:3.4.21.43]
synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43]
synonym: "complement C42" RELATED [EC:3.4.21.43]
-xref: EC:3.4.21.43
-xref: MetaCyc:3.4.21.43-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31714,8 +31611,6 @@ synonym: "activated complement C1r" RELATED [EC:3.4.21.41]
synonym: "C1r esterase activity" EXACT [EC:3.4.21.41]
synonym: "complement component C1r activity" EXACT []
synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41]
-xref: EC:3.4.21.41
-xref: MetaCyc:3.4.21.41-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31731,8 +31626,6 @@ synonym: "C1s esterase activity" EXACT [EC:3.4.21.42]
synonym: "complement C1s" RELATED [EC:3.4.21.42]
synonym: "complement component C1s activity" EXACT []
synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42]
-xref: EC:3.4.21.42
-xref: MetaCyc:3.4.21.42-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31749,8 +31642,6 @@ synonym: "complement factor D activity" EXACT []
synonym: "factor D" RELATED [EC:3.4.21.46]
synonym: "factor D (complement)" RELATED [EC:3.4.21.46]
synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46]
-xref: EC:3.4.21.46
-xref: MetaCyc:3.4.21.46-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31771,8 +31662,6 @@ synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45]
synonym: "complement factor I activity" EXACT []
synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45]
synonym: "factor I" RELATED [EC:3.4.21.45]
-xref: EC:3.4.21.45
-xref: MetaCyc:3.4.21.45-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -31963,6 +31852,7 @@ synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosamin
xref: EC:2.4.1.144
xref: MetaCyc:2.4.1.144-RXN
xref: Reactome:R-HSA-975926 "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3"
+xref: RHEA:15509
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein
@@ -32121,6 +32011,7 @@ xref: EC:4.3.2.9
xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN
xref: Reactome:R-HSA-1247922 "GGCT transforms gGluCys to OPRO"
xref: Reactome:R-HSA-6785928 "CHAC1,2 cleaves GSH to OPRO and CysGly"
+xref: RHEA:20505
is_a: GO:0016842 ! amidine-lyase activity
[Term]
@@ -32222,6 +32113,7 @@ synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EX
synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
xref: EC:2.4.1.34
xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN
+xref: RHEA:21476
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -32460,6 +32352,7 @@ xref: Reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized
xref: Reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one"
xref: Reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione"
xref: Reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol"
+xref: RHEA:24076
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -32588,6 +32481,7 @@ synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33]
synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33]
xref: EC:4.2.1.33
xref: MetaCyc:3-ISOPROPYLMALISOM-RXN
+xref: RHEA:32287
is_a: GO:0016836 ! hydro-lyase activity
[Term]
@@ -32638,6 +32532,7 @@ synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4]
synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4]
xref: EC:1.2.4.4
xref: MetaCyc:1.2.4.4-RXN
+xref: RHEA:13457
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
[Term]
@@ -32721,7 +32616,7 @@ synonym: "gamma-aminobutyric acid transaminase activity" EXACT []
synonym: "gamma-aminobutyric transaminase activity" EXACT []
synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT []
xref: MetaCyc:GABATRANSAM-RXN
-xref: Reactome:R-HSA-916855 "Conversion of GABA to Succinate Semialdehyde"
+xref: Reactome:R-HSA-916855 "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA"
xref: RHEA:23352
is_a: GO:0008483 ! transaminase activity
@@ -33100,6 +32995,7 @@ synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARR
synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37]
xref: EC:2.1.1.37
xref: MetaCyc:2.1.1.73-RXN
+xref: RHEA:13681
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity
relationship: part_of GO:0090116 ! C-5 methylation of cytosine
@@ -33253,6 +33149,7 @@ xref: Reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent tran
xref: Reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition"
xref: Reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript"
xref: Reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition"
+xref: Reactome:R-HSA-9670149 "TERRA transcription"
is_a: GO:0034062 ! 5'-3' RNA polymerase activity
relationship: part_of GO:0032774 ! RNA biosynthetic process
@@ -33361,6 +33258,7 @@ synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD []
xref: EC:2.1.1.63
xref: MetaCyc:2.1.1.63-RXN
xref: Reactome:R-HSA-73892 "MGMT/hAGT mediated DNA Damage Reversal"
+xref: RHEA:24000
is_a: GO:0008172 ! S-methyltransferase activity
[Term]
@@ -33615,8 +33513,7 @@ name: GPI-anchor transamidase activity
namespace: molecular_function
def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309]
xref: Reactome:R-HSA-162836 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide"
-is_a: GO:0016787 ! hydrolase activity
-is_a: GO:0140096 ! catalytic activity, acting on a protein
+is_a: GO:0004197 ! cysteine-type endopeptidase activity
[Term]
id: GO:0003924
@@ -33681,7 +33578,7 @@ xref: Reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4"
xref: Reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP"
xref: Reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity"
xref: Reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments"
-xref: Reactome:R-HSA-5672017 "Rheb in the mTORC1 complex hydrolyses GTP"
+xref: Reactome:R-HSA-5672017 "Rheb in the MTORC1 complex hydrolyses GTP"
xref: Reactome:R-HSA-5694527 "Loss of SAR1B GTPase"
xref: Reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity"
xref: Reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP"
@@ -33698,6 +33595,9 @@ xref: Reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity"
xref: Reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated"
xref: Reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated"
xref: Reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated"
+xref: Reactome:R-HSA-9640195 "RRAGA,B hydrolyzes GTP"
+xref: Reactome:R-HSA-9645598 "RRAGC,D hydrolyzes GTP"
+xref: Reactome:R-HSA-9649736 "RAS intrinsic GTPase activity hydrolyzes GTP to GDP"
xref: Reactome:R-HSA-983422 "Disassembly of COPII coated vesicle"
xref: RHEA:19669
is_a: GO:0017111 ! nucleoside-triphosphatase activity
@@ -33928,6 +33828,7 @@ synonym: "L-hydroxyaminoacid dehydratase activity" BROAD []
synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17]
synonym: "L-serine deaminase activity" EXACT []
synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17]
+synonym: "L-serine dehydration activity" RELATED []
synonym: "L-serine hydro-lyase (deaminating) activity" EXACT []
synonym: "serine deaminase activity" BROAD [EC:4.3.1.17]
xref: EC:4.3.1.17
@@ -33985,6 +33886,7 @@ synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45]
synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45]
xref: EC:3.1.4.45
xref: MetaCyc:3.1.4.45-RXN
+xref: RHEA:24372
is_a: GO:0015929 ! hexosaminidase activity
[Term]
@@ -34108,6 +34010,7 @@ xref: Reactome:R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylat
xref: Reactome:R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD"
xref: Reactome:R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)"
xref: Reactome:R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN"
+xref: Reactome:R-HSA-9686061 "Nucleoprotein is ADP-ribosylated"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
[Term]
@@ -34203,7 +34106,7 @@ synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2]
synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2]
synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2]
synonym: "menadione reductase activity" NARROW [EC:1.6.5.2]
-synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2]
+synonym: "NAD(P)H dehydrogenase activity" BROAD []
synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2]
synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2]
@@ -34214,11 +34117,11 @@ synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2]
synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2]
synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2]
-synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2]
-synonym: "NQO1" RELATED [EC:1.6.5.2]
+synonym: "naphthoquinone reductase activity" NARROW []
+synonym: "NQO1" RELATED []
synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2]
-synonym: "QR1" RELATED [EC:1.6.5.2]
+synonym: "QR1" RELATED []
synonym: "quinone reductase activity" EXACT [EC:1.6.5.2]
synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2]
synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2]
@@ -34227,6 +34130,7 @@ synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2]
synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2]
xref: EC:1.6.5.2
xref: MetaCyc:NQOR-RXN
+xref: RHEA:46164
xref: UM-BBD_reactionID:r0227
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
@@ -34316,6 +34220,7 @@ synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4]
xref: EC:1.6.2.4
xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN
xref: Reactome:R-HSA-76494 "POR reduces CYP450:Fe3+ to CYP450:Fe2+"
+xref: RHEA:24040
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
[Term]
@@ -34360,6 +34265,7 @@ synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5]
xref: EC:1.6.5.5
xref: MetaCyc:QOR-RXN
xref: Reactome:R-HSA-6799722 "TP53I3 oxidoreductase generates unstable semiquinones"
+xref: RHEA:14269
is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
[Term]
@@ -34421,6 +34327,7 @@ synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4]
synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4]
xref: EC:6.5.1.4
xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN
+xref: RHEA:23976
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds
is_a: GO:0140098 ! catalytic activity, acting on RNA
@@ -34502,6 +34409,13 @@ xref: Reactome:R-HSA-192624 "cRNA Extension"
xref: Reactome:R-HSA-192832 "Initiation of cRNA Synthesis"
xref: Reactome:R-HSA-192851 "vRNA Extension"
xref: Reactome:R-HSA-192916 "Initiation of vRNA Synthesis"
+xref: Reactome:R-HSA-9681651 "nsp8 generates RNA primers"
+xref: Reactome:R-HSA-9681674 "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement"
+xref: Reactome:R-HSA-9681840 "RTC synthesizes SARS-CoV-1 plus strand genomic RNA"
+xref: Reactome:R-HSA-9682465 "RTC completes synthesis of the minus strand genomic RNA complement"
+xref: Reactome:R-HSA-9682563 "nsp12 misincorporates a nucleotide in nascent RNA minus strand"
+xref: Reactome:R-HSA-9685639 "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching"
+xref: Reactome:R-HSA-9685681 "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs"
is_a: GO:0034062 ! 5'-3' RNA polymerase activity
relationship: part_of GO:0001172 ! transcription, RNA-templated
@@ -34542,6 +34456,7 @@ synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15]
xref: EC:1.1.3.15
xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN
+xref: RHEA:16789
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
[Term]
@@ -34599,6 +34514,7 @@ synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotra
synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
xref: EC:2.7.8.17
xref: MetaCyc:2.7.8.17-RXN
+xref: RHEA:13581
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
[Term]
@@ -34795,30 +34711,30 @@ name: acetyl-CoA C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16]
synonym: "2-keto-acyl thiolase activity" EXACT []
-synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16]
+synonym: "2-methylacetoacetyl-CoA thiolase" BROAD []
synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16]
+synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT []
+synonym: "3-ketoacyl thiolase activity" EXACT []
synonym: "3-ketoacyl-CoA thiolase activity" EXACT []
-synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16]
-synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16]
-synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16]
+synonym: "3-ketothiolase activity" EXACT []
+synonym: "3-oxoacyl-CoA thiolase activity" EXACT []
+synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT []
+synonym: "6-oxoacyl-CoA thiolase activity" EXACT []
+synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT []
+synonym: "acetyl-CoA acyltransferase activity" EXACT []
synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16]
-synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16]
-synonym: "KAT" RELATED [EC:2.3.1.16]
-synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16]
-synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
-synonym: "thiolase I" RELATED [EC:2.3.1.16]
+synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT []
+synonym: "beta-ketoacyl-CoA thiolase activity" NARROW []
+synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT []
+synonym: "beta-ketoadipyl-CoA thiolase activity" NARROW []
+synonym: "beta-ketothiolase activity" EXACT []
+synonym: "KAT" RELATED []
+synonym: "ketoacyl-CoA acyltransferase activity" EXACT []
+synonym: "ketoacyl-coenzyme A thiolase activity" EXACT []
+synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT []
+synonym: "oxoacyl-coenzyme A thiolase activity" EXACT []
+synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT []
+synonym: "thiolase I" RELATED []
xref: EC:2.3.1.16
xref: MetaCyc:KETOACYLCOATHIOL-RXN
xref: Reactome:R-HSA-390250 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA"
@@ -35008,6 +34924,7 @@ xref: Reactome:R-HSA-192335 "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,1
xref: Reactome:R-HSA-193369 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA"
xref: Reactome:R-HSA-2066787 "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA"
xref: Reactome:R-HSA-390256 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2"
+xref: RHEA:38959
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
[Term]
@@ -35303,10 +35220,10 @@ synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2]
xref: EC:2.6.1.2
xref: KEGG_REACTION:R00258
xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN
-xref: Reactome:R-HSA-507749 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2]"
-xref: Reactome:R-HSA-507775 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2]"
-xref: Reactome:R-HSA-70523 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT]"
-xref: Reactome:R-HSA-70524 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT]"
+xref: Reactome:R-HSA-507749 "PXLP-K341-GPT2 transaminates PYR to form L-Ala"
+xref: Reactome:R-HSA-507775 "PXLP-K341-GPT2 transaminates L-Ala to form PYR"
+xref: Reactome:R-HSA-70523 "PXLP-K314-GPT transaminates L-Ala to form PYR"
+xref: Reactome:R-HSA-70524 "PXLP-K314-GPT transaminates PYR to form L-Ala"
xref: RHEA:19453
is_a: GO:0047635 ! alanine-oxo-acid transaminase activity
@@ -35331,6 +35248,7 @@ synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1]
xref: EC:1.1.1.1
xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN
xref: Reactome:R-HSA-2162078 "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+"
+xref: RHEA:10740
xref: UM-BBD_enzymeID:e0023
is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity
@@ -35366,6 +35284,7 @@ synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84]
synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84]
xref: EC:2.3.1.84
xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN
+xref: RHEA:17229
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity
@@ -35396,6 +35315,7 @@ xref: EC:2.8.2.2
xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-176494 "SULTs transfer (SO4)2- group to 27HCHOL"
xref: Reactome:R-HSA-176609 "cholesterol + PAPS => cholesterol sulfate + PAP"
+xref: RHEA:22552
is_a: GO:0008146 ! sulfotransferase activity
[Term]
@@ -35477,6 +35397,7 @@ xref: KEGG_REACTION:R02820
xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN
xref: Reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol"
xref: Reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol"
+xref: RHEA:12789
is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity
[Term]
@@ -35500,7 +35421,7 @@ xref: Reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is re
xref: Reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one"
xref: Reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one"
xref: Reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol"
-xref: Reactome:R-HSA-198845 "CYB5A:heme reduces SDA to VitC"
+xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-"
xref: Reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL"
xref: Reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH"
xref: Reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione"
@@ -35591,6 +35512,7 @@ synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4]
synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4]
xref: EC:3.5.1.4
xref: MetaCyc:AMIDASE-RXN
+xref: RHEA:12020
xref: UM-BBD_enzymeID:e0068
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
@@ -35630,6 +35552,7 @@ synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleot
xref: EC:1.2.1.31
xref: MetaCyc:1.2.1.31-RXN
xref: Reactome:R-HSA-70941 "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+"
+xref: RHEA:12308
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -35672,6 +35595,7 @@ synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1
synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29]
xref: EC:3.1.1.29
xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN
+xref: RHEA:54448
is_a: GO:0052689 ! carboxylic ester hydrolase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -35917,6 +35841,7 @@ synonym: "arginyl-tRNA-protein transferase activity" EXACT []
synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8]
xref: EC:2.3.2.8
xref: MetaCyc:ARGINYLTRANSFERASE-RXN
+xref: RHEA:10208
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
relationship: part_of GO:0016598 ! protein arginylation
@@ -35955,6 +35880,7 @@ synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87]
xref: EC:2.3.1.87
xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:R-HSA-209792 "N-acetylation of serotonin"
+xref: RHEA:20497
is_a: GO:0008080 ! N-acetyltransferase activity
[Term]
@@ -35975,6 +35901,7 @@ xref: EC:2.3.1.5
xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:R-HSA-174963 "NAT1 acetylation"
xref: Reactome:R-HSA-174967 "NAT2 acetylation"
+xref: RHEA:16613
xref: UM-BBD_enzymeID:e0341
is_a: GO:0008080 ! N-acetyltransferase activity
@@ -36024,6 +35951,7 @@ xref: Reactome:R-HSA-159358 "SULT1A3,4 dimers sulfate DA to DAOS"
xref: Reactome:R-HSA-176474 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP"
xref: Reactome:R-HSA-176585 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP"
xref: Reactome:R-HSA-176646 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP"
+xref: RHEA:12164
is_a: GO:0008146 ! sulfotransferase activity
[Term]
@@ -36033,21 +35961,22 @@ namespace: molecular_function
def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1]
synonym: "A-esterase activity" BROAD [EC:3.1.8.1]
synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1]
-synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1]
+synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT []
synonym: "esterase B1" RELATED [EC:3.1.8.1]
synonym: "esterase E4" RELATED [EC:3.1.8.1]
synonym: "OPH" RELATED [EC:3.1.8.1]
-synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1]
-synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1]
-synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1]
-synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1]
-synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1]
+synonym: "organophosphate esterase activity" BROAD []
+synonym: "organophosphate hydrolase activity" BROAD []
+synonym: "organophosphorus acid anhydrase activity" BROAD []
+synonym: "organophosphorus hydrolase activity" BROAD []
+synonym: "paraoxon esterase activity" NARROW []
synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1]
synonym: "paraoxonase activity" BROAD [EC:3.1.8.1]
-synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1]
-synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1]
+synonym: "phosphotriesterase activity" NARROW [EC:3.1.8.1]
+synonym: "pirimiphos-methyloxon esterase activity" NARROW []
xref: EC:3.1.8.1
xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN
+xref: RHEA:18053
xref: UM-BBD_enzymeID:e0054
is_a: GO:0016791 ! phosphatase activity
@@ -36062,6 +35991,7 @@ synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2]
synonym: "paraoxonase activity" BROAD [EC:3.1.1.2]
xref: EC:3.1.1.2
xref: MetaCyc:ARYLESTERASE-RXN
+xref: RHEA:17309
xref: UM-BBD_reactionID:r0757
is_a: GO:0052689 ! carboxylic ester hydrolase activity
@@ -36084,6 +36014,7 @@ synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1]
synonym: "sulfatase activity" RELATED [EC:3.1.6.1]
xref: EC:3.1.6.1
xref: MetaCyc:ARYLSULFAT-RXN
+xref: RHEA:17261
is_a: GO:0008484 ! sulfuric ester hydrolase activity
[Term]
@@ -36178,8 +36109,8 @@ xref: EC:2.6.1.1
xref: KEGG_REACTION:R00355
xref: MetaCyc:ASPAMINOTRANS-RXN
xref: Reactome:R-HSA-70581 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]"
-xref: Reactome:R-HSA-70592 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]"
-xref: Reactome:R-HSA-70596 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]"
+xref: Reactome:R-HSA-70592 "PXLP-K259-GOT1 dimer deaminates L-Asp"
+xref: Reactome:R-HSA-70596 "GOT2 dimer deaminates L-Asp"
xref: Reactome:R-HSA-70613 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]"
xref: RHEA:21824
is_a: GO:0008483 ! transaminase activity
@@ -36257,13 +36188,14 @@ is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group
[Term]
id: GO:0004074
-name: biliverdin reductase activity
+name: biliverdin reductase (NAD(P)+) activity
namespace: molecular_function
def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24]
synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24]
xref: EC:1.3.1.24
xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN
-xref: Reactome:R-HSA-189384 "Biliverdin is reduced to bilirubin"
+xref: Reactome:R-HSA-189384 "BLVRA:Zn2+, BLVRB reduce BV to BIL"
+xref: RHEA:15793
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -36275,6 +36207,7 @@ synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXA
synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14]
xref: EC:6.3.4.14
xref: MetaCyc:BIOTIN-CARBOXYL-RXN
+xref: RHEA:13501
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
[Term]
@@ -36309,6 +36242,7 @@ synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15]
synonym: "HCS" RELATED [EC:6.3.4.15]
xref: EC:6.3.4.15
xref: MetaCyc:BIOTINLIG-RXN
+xref: RHEA:11756
is_a: GO:0018271 ! biotin-protein ligase activity
[Term]
@@ -36324,6 +36258,7 @@ synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11]
synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11]
xref: EC:6.3.4.11
xref: MetaCyc:6.3.4.11-RXN
+xref: RHEA:24376
is_a: GO:0018271 ! biotin-protein ligase activity
[Term]
@@ -36346,6 +36281,7 @@ synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-fo
synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9]
xref: EC:6.3.4.9
xref: MetaCyc:6.3.4.9-RXN
+xref: RHEA:23668
is_a: GO:0018271 ! biotin-protein ligase activity
[Term]
@@ -36363,6 +36299,7 @@ synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.
synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10]
xref: EC:6.3.4.10
xref: MetaCyc:6.3.4.10-RXN
+xref: RHEA:11204
is_a: GO:0018271 ! biotin-protein ligase activity
[Term]
@@ -36697,6 +36634,7 @@ synonym: "cerebroside-sulphatase activity" EXACT []
xref: EC:3.1.6.8
xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN
xref: Reactome:R-HSA-1606807 "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside"
+xref: RHEA:21300
is_a: GO:0008484 ! sulfuric ester hydrolase activity
[Term]
@@ -36724,6 +36662,7 @@ synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16]
synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16]
xref: EC:2.4.1.16
xref: MetaCyc:CHITIN-SYNTHASE-RXN
+xref: RHEA:16637
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
[Term]
@@ -36747,10 +36686,10 @@ id: GO:0004103
name: choline kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12837]
-synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32]
-synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32]
-synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32]
-synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32]
+synonym: "ATP:choline phosphotransferase activity" RELATED []
+synonym: "choline kinase (phosphorylating)" RELATED []
+synonym: "choline phosphokinase activity" RELATED []
+synonym: "choline-ethanolamine kinase activity" RELATED []
xref: EC:2.7.1.32
xref: KEGG_REACTION:R01021
xref: MetaCyc:CHOLINE-KINASE-RXN
@@ -36944,6 +36883,7 @@ synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37]
synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37]
xref: EC:3.1.4.37
xref: MetaCyc:3.1.4.37-RXN
+xref: RHEA:14489
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity
[Term]
@@ -36987,9 +36927,11 @@ synonym: "cAMP-specific phosphodiesterase activity" EXACT []
synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT []
xref: EC:3.1.4
xref: MetaCyc:RXN0-5038
-xref: Reactome:R-HSA-111962 "cAMP hydrolysis by PDE 4"
+xref: Reactome:R-HSA-111962 "PDE4A,C,D hydrolyse cAMP"
xref: Reactome:R-HSA-418553 "cAMP degradation by Phosphodiesterases"
xref: Reactome:R-HSA-9629675 "PDE3A,3B hydrolyses cAMP to AMP"
+xref: Reactome:R-HSA-9644869 "p-S54-PDE4B hydrolyses cAMP"
+xref: RHEA:25277
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity
[Term]
@@ -37055,7 +36997,7 @@ synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22]
synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22]
xref: EC:4.2.1.22
xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN
-xref: Reactome:R-HSA-1614524 "Cystathionine is formed from homocysteine and serine"
+xref: Reactome:R-HSA-1614524 "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine"
xref: RHEA:10112
is_a: GO:0016836 ! hydro-lyase activity
@@ -37074,7 +37016,7 @@ synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)"
xref: EC:4.4.1.1
xref: KEGG_REACTION:R01001
xref: MetaCyc:CYSTAGLY-RXN
-xref: Reactome:R-HSA-1614583 "Cleavage of cystathionine into cysteine"
+xref: Reactome:R-HSA-1614583 "PXLP-K212-CTH cleaves L-Cystathionine"
xref: RHEA:14005
is_a: GO:0016846 ! carbon-sulfur lyase activity
@@ -37122,6 +37064,7 @@ synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT []
synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1]
xref: EC:2.9.1.1
xref: MetaCyc:2.9.1.1-RXN
+xref: RHEA:22728
is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -37177,6 +37120,7 @@ xref: EC:1.6.2.2
xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN
xref: Reactome:R-HSA-198824 "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme"
xref: Reactome:R-HSA-6806831 "CYB5Rs reduce MetHb to HbA"
+xref: RHEA:46680
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
[Term]
@@ -37203,6 +37147,7 @@ synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1]
xref: EC:1.9.3.1
xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN
xref: Reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen"
+xref: RHEA:11436
is_a: GO:0009055 ! electron transfer activity
is_a: GO:0015002 ! heme-copper terminal oxidase activity
is_a: GO:0015078 ! proton transmembrane transporter activity
@@ -37224,6 +37169,7 @@ synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5]
xref: EC:1.11.1.5
xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN
+xref: RHEA:16581
is_a: GO:0004601 ! peroxidase activity
[Term]
@@ -37583,6 +37529,7 @@ synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:
synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61]
xref: EC:2.3.1.61
+xref: RHEA:15213
is_a: GO:0016751 ! S-succinyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -38002,6 +37949,7 @@ synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1]
xref: EC:1.5.5.1
xref: MetaCyc:1.5.5.1-RXN
xref: Reactome:R-HSA-169270 "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2"
+xref: RHEA:24052
is_a: GO:0009055 ! electron transfer activity
is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
relationship: part_of GO:0022904 ! respiratory electron transport chain
@@ -38016,6 +37964,7 @@ synonym: "elastase activity" RELATED [GOC:krc]
synonym: "endoprotease activity" NARROW []
synonym: "proteasome endopeptidase activity" NARROW []
synonym: "proteinase" NARROW []
+xref: EC:3.4.99
xref: MetaCyc:RXN0-5195
xref: Reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded"
xref: Reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha"
@@ -38088,9 +38037,10 @@ xref: Reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2"
xref: Reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)"
xref: Reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1"
xref: Reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4"
+xref: Reactome:R-HSA-9614271 "Autocleavage of ADGRG6"
xref: Reactome:R-HSA-983150 "Proteasomal cleavage of substrate"
xref: Reactome:R-HSA-983158 "Trimming of peptides in ER"
-is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides
+is_a: GO:0008233 ! peptidase activity
[Term]
id: GO:0004176
@@ -38099,8 +38049,8 @@ namespace: molecular_function
alt_id: GO:0004280
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah]
synonym: "ATP-dependent proteolysis" RELATED [GOC:mah]
+is_a: GO:0008233 ! peptidase activity
is_a: GO:0016887 ! ATPase activity
-is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides
[Term]
id: GO:0004177
@@ -38108,6 +38058,14 @@ name: aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]
xref: EC:3.4.11
+xref: EC:3.4.11.21
+xref: EC:3.4.11.5
+xref: EC:3.4.11.6
+xref: EC:3.4.11.9
+xref: MetaCyc:3.4.11.21-RXN
+xref: MetaCyc:3.4.11.5-RXN
+xref: MetaCyc:3.4.11.6-RXN
+xref: MetaCyc:3.4.11.9-RXN
xref: MetaCyc:RXN0-5052
xref: Reactome:R-HSA-1236954 "Trimming of peptides by IRAP in endocytic vesicles"
xref: Reactome:R-HSA-2534096 "METAP1/2 demethylates GNAT1"
@@ -38172,7 +38130,10 @@ id: GO:0004180
name: carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]
+xref: EC:3.4.17.11
+xref: MetaCyc:3.4.17.11-RXN
xref: Reactome:R-HSA-1247910 "CNDP2:2Mn2+ dimer hydrolyses CysGly"
+xref: RHEA:28783
is_a: GO:0008238 ! exopeptidase activity
[Term]
@@ -38181,6 +38142,23 @@ name: metallocarboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]
xref: EC:3.4.17
+xref: EC:3.4.17.1
+xref: EC:3.4.17.10
+xref: EC:3.4.17.17
+xref: EC:3.4.17.2
+xref: EC:3.4.17.21
+xref: EC:3.4.17.22
+xref: EC:3.4.17.3
+xref: EC:3.4.17.4
+xref: EC:3.4.17.6
+xref: MetaCyc:3.4.17.17-RXN
+xref: MetaCyc:3.4.17.22-RXN
+xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN
+xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN
+xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN
+xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN
+xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN
+xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN
xref: Reactome:R-HSA-2022378 "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)"
xref: Reactome:R-HSA-2022379 "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)"
xref: Reactome:R-HSA-2028294 "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)"
@@ -38203,8 +38181,6 @@ synonym: "carboxypeptidase A activity" EXACT []
synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1]
synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1]
synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1]
-xref: EC:3.4.17.1
-xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN
is_obsolete: true
replaced_by: GO:0004181
@@ -38223,8 +38199,6 @@ synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10]
synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10]
-xref: EC:3.4.17.10
-xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN
is_obsolete: true
replaced_by: GO:0004181
@@ -38250,8 +38224,6 @@ synonym: "lysine carboxypeptidase activity" EXACT []
synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3]
synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3]
-xref: EC:3.4.17.3
-xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004181
@@ -38262,6 +38234,12 @@ namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
synonym: "serine carboxypeptidase activity" EXACT []
xref: EC:3.4.16
+xref: EC:3.4.16.2
+xref: EC:3.4.16.5
+xref: EC:3.4.16.6
+xref: MetaCyc:3.4.16.2-RXN
+xref: MetaCyc:3.4.16.5-RXN
+xref: MetaCyc:3.4.16.6-RXN
xref: Reactome:R-HSA-158251 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer"
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0070008 ! serine-type exopeptidase activity
@@ -38281,8 +38259,6 @@ synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5]
synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5]
synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5]
synonym: "vacuolar carboxypeptidase Y" NARROW []
-xref: EC:3.4.16.5
-xref: MetaCyc:3.4.16.5-RXN
is_obsolete: true
replaced_by: GO:0004185
@@ -38303,8 +38279,6 @@ synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6]
synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6]
synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6]
synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6]
-xref: EC:3.4.16.6
-xref: MetaCyc:3.4.16.6-RXN
is_obsolete: true
replaced_by: GO:0004185
@@ -38326,8 +38300,6 @@ synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2]
synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "serine-type Pro-X carboxypeptidase activity" EXACT []
-xref: EC:3.4.16.2
-xref: MetaCyc:3.4.16.2-RXN
is_obsolete: true
replaced_by: GO:0004185
@@ -38348,8 +38320,6 @@ synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT []
synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
-xref: EC:3.4.17.17
-xref: MetaCyc:3.4.17.17-RXN
is_obsolete: true
replaced_by: GO:0004181
@@ -38364,6 +38334,28 @@ synonym: "aspartic protease activity" NARROW []
synonym: "aspartyl protease activity" NARROW []
synonym: "carboxyl protease activity" NARROW []
xref: EC:3.4.23
+xref: EC:3.4.23.1
+xref: EC:3.4.23.15
+xref: EC:3.4.23.20
+xref: EC:3.4.23.25
+xref: EC:3.4.23.32
+xref: EC:3.4.23.34
+xref: EC:3.4.23.35
+xref: EC:3.4.23.36
+xref: EC:3.4.23.4
+xref: EC:3.4.23.43
+xref: EC:3.4.23.5
+xref: MetaCyc:3.4.23.1-RXN
+xref: MetaCyc:3.4.23.15-RXN
+xref: MetaCyc:3.4.23.20-RXN
+xref: MetaCyc:3.4.23.25-RXN
+xref: MetaCyc:3.4.23.32-RXN
+xref: MetaCyc:3.4.23.34-RXN
+xref: MetaCyc:3.4.23.35-RXN
+xref: MetaCyc:3.4.23.36-RXN
+xref: MetaCyc:3.4.23.4-RXN
+xref: MetaCyc:3.4.23.43-RXN
+xref: MetaCyc:3.4.23.5-RXN
xref: Reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1"
xref: Reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2"
xref: Reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)"
@@ -38387,8 +38379,6 @@ synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35]
synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35]
synonym: "barrierpepsin activity" EXACT []
synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35]
-xref: EC:3.4.23.35
-xref: MetaCyc:3.4.23.35-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -38399,8 +38389,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin D activity" EXACT []
-xref: EC:3.4.23.5
-xref: MetaCyc:3.4.23.5-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -38419,8 +38407,6 @@ synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.3
synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34]
synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34]
synonym: "SMP" RELATED [EC:3.4.23.34]
-xref: EC:3.4.23.34
-xref: MetaCyc:3.4.23.34-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -38441,8 +38427,6 @@ synonym: "pepsin activity" BROAD [EC:3.4.23.1]
synonym: "pepsin D" RELATED [EC:3.4.23.1]
synonym: "pepsin fortior" RELATED [EC:3.4.23.1]
synonym: "pepsin R" RELATED [EC:3.4.23.1]
-xref: EC:3.4.23.1
-xref: MetaCyc:3.4.23.1-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -38455,8 +38439,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15]
synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15]
synonym: "renin activity" EXACT []
-xref: EC:3.4.23.15
-xref: MetaCyc:3.4.23.15-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -38476,8 +38458,6 @@ synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25]
synonym: "saccharopepsin activity" EXACT []
synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25]
synonym: "yeast proteinase A" RELATED [EC:3.4.23.25]
-xref: EC:3.4.23.25
-xref: MetaCyc:3.4.23.25-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -38491,6 +38471,26 @@ synonym: "lysosomal cysteine-type endopeptidase" NARROW []
synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis]
synonym: "thiol endopeptidase activity" EXACT []
xref: EC:3.4.22
+xref: EC:3.4.22.1
+xref: EC:3.4.22.14
+xref: EC:3.4.22.15
+xref: EC:3.4.22.16
+xref: EC:3.4.22.27
+xref: EC:3.4.22.28
+xref: EC:3.4.22.34
+xref: EC:3.4.22.38
+xref: EC:3.4.22.40
+xref: EC:3.4.22.41
+xref: EC:3.4.22.8
+xref: MetaCyc:3.4.22.1-RXN
+xref: MetaCyc:3.4.22.14-RXN
+xref: MetaCyc:3.4.22.15-RXN
+xref: MetaCyc:3.4.22.16-RXN
+xref: MetaCyc:3.4.22.27-RXN
+xref: MetaCyc:3.4.22.34-RXN
+xref: MetaCyc:3.4.22.38-RXN
+xref: MetaCyc:3.4.22.40-RXN
+xref: MetaCyc:3.4.22.41-RXN
xref: Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome"
xref: Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9"
xref: Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome"
@@ -38551,7 +38551,7 @@ xref: Reactome:R-HSA-418845 "Activation of caspase-3"
xref: Reactome:R-HSA-418846 "Caspase cleavage of UNC5A"
xref: Reactome:R-HSA-418852 "Caspase cleavage of UNC5B"
xref: Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1"
-xref: Reactome:R-HSA-5357828 "RIP1 is cleaved by CASP8"
+xref: Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8"
xref: Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases"
xref: Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor"
xref: Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4"
@@ -38561,6 +38561,14 @@ xref: Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL3
xref: Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex"
xref: Reactome:R-HSA-933532 "Processing of caspases"
xref: Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3"
+xref: Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins"
+xref: Reactome:R-HSA-9684273 "3CLp cleaves pp1a"
+xref: Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11"
+xref: Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4"
+xref: Reactome:R-HSA-9684336 "nsp1-4 cleaves itself"
+xref: Reactome:R-HSA-9684340 "3CLp cleaves pp1ab"
+xref: Reactome:R-HSA-9684351 "pp1a cleaves itself"
+xref: Reactome:R-HSA-9684352 "nsp3-4 cleaves itself"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008234 ! cysteine-type peptidase activity
@@ -38718,8 +38726,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin B activity" EXACT []
synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1]
synonym: "cathepsin II" RELATED [EC:3.4.22.1]
-xref: EC:3.4.22.1
-xref: MetaCyc:3.4.22.1-RXN
is_obsolete: true
replaced_by: GO:0004197
@@ -38755,8 +38761,6 @@ synonym: "cathepsin Ba" RELATED [EC:3.4.22.16]
synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16]
synonym: "cathepsin H activity" EXACT []
synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16]
-xref: EC:3.4.22.16
-xref: MetaCyc:3.4.22.16-RXN
is_obsolete: true
replaced_by: GO:0004197
@@ -38770,8 +38774,6 @@ synonym: "cathepsin K activity" EXACT []
synonym: "cathepsin O activity" EXACT [EC:3.4.22.38]
synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38]
synonym: "cathepsin X activity" EXACT [EC:3.4.22.38]
-xref: EC:3.4.22.38
-xref: MetaCyc:3.4.22.38-RXN
is_obsolete: true
replaced_by: GO:0004197
@@ -38783,8 +38785,6 @@ def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close
comment: This term was made obsolete because it represents a gene product.
synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15]
synonym: "cathepsin L activity" EXACT []
-xref: EC:3.4.22.15
-xref: MetaCyc:3.4.22.15-RXN
is_obsolete: true
replaced_by: GO:0004197
@@ -38795,8 +38795,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin S activity" EXACT []
-xref: EC:3.4.22.27
-xref: MetaCyc:3.4.22.27-RXN
is_obsolete: true
replaced_by: GO:0004197
@@ -38843,7 +38841,6 @@ xref: KEGG_REACTION:R02418
xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN
is_obsolete: true
consider: GO:0004843
-consider: GO:0036459
[Term]
id: GO:0004222
@@ -38853,6 +38850,48 @@ def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypept
synonym: "metalloendoprotease activity" NARROW [GOC:mah]
synonym: "metalloendoproteinase activity" NARROW [GOC:mah]
xref: EC:3.4.24
+xref: EC:3.4.24.11
+xref: EC:3.4.24.14
+xref: EC:3.4.24.17
+xref: EC:3.4.24.18
+xref: EC:3.4.24.19
+xref: EC:3.4.24.21
+xref: EC:3.4.24.22
+xref: EC:3.4.24.23
+xref: EC:3.4.24.24
+xref: EC:3.4.24.35
+xref: EC:3.4.24.37
+xref: EC:3.4.24.55
+xref: EC:3.4.24.56
+xref: EC:3.4.24.57
+xref: EC:3.4.24.59
+xref: EC:3.4.24.61
+xref: EC:3.4.24.64
+xref: EC:3.4.24.69
+xref: EC:3.4.24.70
+xref: EC:3.4.24.71
+xref: EC:3.4.24.72
+xref: MetaCyc:3.4.24.11-RXN
+xref: MetaCyc:3.4.24.14-RXN
+xref: MetaCyc:3.4.24.17-RXN
+xref: MetaCyc:3.4.24.18-RXN
+xref: MetaCyc:3.4.24.19-RXN
+xref: MetaCyc:3.4.24.21-RXN
+xref: MetaCyc:3.4.24.22-RXN
+xref: MetaCyc:3.4.24.23-RXN
+xref: MetaCyc:3.4.24.24-RXN
+xref: MetaCyc:3.4.24.35-RXN
+xref: MetaCyc:3.4.24.37-RXN
+xref: MetaCyc:3.4.24.55-RXN
+xref: MetaCyc:3.4.24.56-RXN
+xref: MetaCyc:3.4.24.57-RXN
+xref: MetaCyc:3.4.24.59-RXN
+xref: MetaCyc:3.4.24.61-RXN
+xref: MetaCyc:3.4.24.64-RXN
+xref: MetaCyc:3.4.24.69-RXN
+xref: MetaCyc:3.4.24.70-RXN
+xref: MetaCyc:3.4.24.71-RXN
+xref: MetaCyc:3.4.24.72-RXN
xref: Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR"
xref: Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17"
xref: Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors"
@@ -38962,8 +39001,6 @@ synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4]
synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4]
synonym: "peptidase alpha" RELATED [EC:3.4.17.4]
synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4]
-xref: EC:3.4.17.4
-xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004181
@@ -38986,8 +39023,6 @@ synonym: "MMP-2" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24]
synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24]
synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24]
-xref: EC:3.4.24.24
-xref: MetaCyc:3.4.24.24-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39010,8 +39045,6 @@ synonym: "MMP 9" RELATED [EC:3.4.24.35]
synonym: "MMP-9" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35]
synonym: "type V collagenase activity" EXACT [EC:3.4.24.35]
-xref: EC:3.4.24.35
-xref: MetaCyc:3.4.24.35-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39053,8 +39086,6 @@ synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56]
synonym: "insulinase activity" EXACT [EC:3.4.24.56]
synonym: "insulysin activity" EXACT []
synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56]
-xref: EC:3.4.24.56
-xref: MetaCyc:3.4.24.56-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39068,8 +39099,6 @@ synonym: "interstitial collagenase activity" EXACT []
synonym: "matrix metalloproteinase 1" EXACT []
synonym: "MMP-1" EXACT []
synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7]
-xref: EC:3.4.24.7
-xref: MetaCyc:3.4.24.7-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39111,8 +39140,6 @@ synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23]
synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23]
synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23]
synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23]
-xref: EC:3.4.24.23
-xref: MetaCyc:3.4.24.23-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39153,8 +39180,6 @@ synonym: "meprin-a" RELATED [EC:3.4.24.18]
synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18]
synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18]
synonym: "PPH" RELATED [EC:3.4.24.18]
-xref: EC:3.4.24.18
-xref: MetaCyc:3.4.24.18-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39192,8 +39217,6 @@ synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT
synonym: "MPP" EXACT []
synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64]
synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64]
-xref: EC:3.4.24.64
-xref: MetaCyc:3.4.24.64-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39230,8 +39253,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "MIP" BROAD []
synonym: "mitochondrial intermediate peptidase activity" EXACT []
synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59]
-xref: EC:3.4.24.59
-xref: MetaCyc:3.4.24.59-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39243,7 +39264,6 @@ def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins
comment: This term was made obsolete because it represents a gene product.
synonym: "IMP" BROAD []
synonym: "mitochondrial inner membrane peptidase activity" EXACT []
-xref: EC:3.4.99
is_obsolete: true
replaced_by: GO:0004175
@@ -39273,8 +39293,6 @@ synonym: "neprilysin activity" EXACT []
synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11]
synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11]
synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11]
-xref: EC:3.4.24.11
-xref: MetaCyc:3.4.24.11-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39319,8 +39337,6 @@ synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37]
synonym: "saccharolysin activity" EXACT []
synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37]
synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37]
-xref: EC:3.4.24.37
-xref: MetaCyc:3.4.24.37-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39340,8 +39356,6 @@ synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17]
synonym: "stromelysin" RELATED [EC:3.4.24.17]
synonym: "stromelysin 1 activity" EXACT []
synonym: "transin activity" EXACT [EC:3.4.24.17]
-xref: EC:3.4.24.17
-xref: MetaCyc:3.4.24.17-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -39354,7 +39368,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 11" EXACT []
synonym: "MMP-11" EXACT []
synonym: "stromelysin 3 activity" EXACT []
-xref: EC:3.4.24
is_obsolete: true
replaced_by: GO:0004222
@@ -39403,7 +39416,102 @@ def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypept
subset: goslim_chembl
synonym: "blood coagulation factor activity" RELATED []
synonym: "serine elastase activity" RELATED [GOC:krc]
+xref: EC:3.4.19.1
xref: EC:3.4.21
+xref: EC:3.4.21.1
+xref: EC:3.4.21.10
+xref: EC:3.4.21.102
+xref: EC:3.4.21.20
+xref: EC:3.4.21.21
+xref: EC:3.4.21.22
+xref: EC:3.4.21.26
+xref: EC:3.4.21.27
+xref: EC:3.4.21.34
+xref: EC:3.4.21.35
+xref: EC:3.4.21.36
+xref: EC:3.4.21.38
+xref: EC:3.4.21.39
+xref: EC:3.4.21.4
+xref: EC:3.4.21.41
+xref: EC:3.4.21.42
+xref: EC:3.4.21.43
+xref: EC:3.4.21.45
+xref: EC:3.4.21.46
+xref: EC:3.4.21.47
+xref: EC:3.4.21.48
+xref: EC:3.4.21.5
+xref: EC:3.4.21.53
+xref: EC:3.4.21.54
+xref: EC:3.4.21.59
+xref: EC:3.4.21.6
+xref: EC:3.4.21.61
+xref: EC:3.4.21.62
+xref: EC:3.4.21.68
+xref: EC:3.4.21.69
+xref: EC:3.4.21.7
+xref: EC:3.4.21.71
+xref: EC:3.4.21.73
+xref: EC:3.4.21.75
+xref: EC:3.4.21.78
+xref: EC:3.4.21.79
+xref: EC:3.4.21.83
+xref: EC:3.4.21.87
+xref: EC:3.4.21.88
+xref: EC:3.4.21.89
+xref: EC:3.4.21.9
+xref: EC:3.4.21.92
+xref: EC:3.4.21.93
+xref: EC:3.4.21.94
+xref: EC:3.4.24.3
+xref: EC:3.4.24.34
+xref: EC:3.4.24.7
+xref: MetaCyc:3.4.21.1-RXN
+xref: MetaCyc:3.4.21.10-RXN
+xref: MetaCyc:3.4.21.102-RXN
+xref: MetaCyc:3.4.21.20-RXN
+xref: MetaCyc:3.4.21.21-RXN
+xref: MetaCyc:3.4.21.22-RXN
+xref: MetaCyc:3.4.21.26-RXN
+xref: MetaCyc:3.4.21.27-RXN
+xref: MetaCyc:3.4.21.34-RXN
+xref: MetaCyc:3.4.21.35-RXN
+xref: MetaCyc:3.4.21.36-RXN
+xref: MetaCyc:3.4.21.38-RXN
+xref: MetaCyc:3.4.21.39-RXN
+xref: MetaCyc:3.4.21.4-RXN
+xref: MetaCyc:3.4.21.41-RXN
+xref: MetaCyc:3.4.21.42-RXN
+xref: MetaCyc:3.4.21.43-RXN
+xref: MetaCyc:3.4.21.45-RXN
+xref: MetaCyc:3.4.21.46-RXN
+xref: MetaCyc:3.4.21.47-RXN
+xref: MetaCyc:3.4.21.48-RXN
+xref: MetaCyc:3.4.21.5-RXN
+xref: MetaCyc:3.4.21.53-RXN
+xref: MetaCyc:3.4.21.54-RXN
+xref: MetaCyc:3.4.21.59-RXN
+xref: MetaCyc:3.4.21.6-RXN
+xref: MetaCyc:3.4.21.61-RXN
+xref: MetaCyc:3.4.21.62-RXN
+xref: MetaCyc:3.4.21.68-RXN
+xref: MetaCyc:3.4.21.69-RXN
+xref: MetaCyc:3.4.21.7-RXN
+xref: MetaCyc:3.4.21.71-RXN
+xref: MetaCyc:3.4.21.73-RXN
+xref: MetaCyc:3.4.21.75-RXN
+xref: MetaCyc:3.4.21.78-RXN
+xref: MetaCyc:3.4.21.79-RXN
+xref: MetaCyc:3.4.21.83-RXN
+xref: MetaCyc:3.4.21.87-RXN
+xref: MetaCyc:3.4.21.88-RXN
+xref: MetaCyc:3.4.21.89-RXN
+xref: MetaCyc:3.4.21.9-RXN
+xref: MetaCyc:3.4.21.92-RXN
+xref: MetaCyc:3.4.21.93-RXN
+xref: MetaCyc:3.4.21.94-RXN
+xref: MetaCyc:3.4.24.34-RXN
+xref: MetaCyc:3.4.24.7-RXN
+xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN
xref: Reactome:R-HSA-114697 "Thrombin-mediated activation of Proteinase-activated receptors"
xref: Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein"
xref: Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage"
@@ -39557,6 +39665,16 @@ xref: Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1"
xref: Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2"
xref: Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1"
xref: Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4"
+xref: Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin"
+xref: Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1"
+xref: Reactome:R-HSA-9662786 "FURIN cleaves ADAM17"
+xref: Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin"
+xref: Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L"
+xref: Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa"
+xref: Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa"
+xref: Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)"
+xref: Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2"
+xref: Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis"
xref: Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b"
xref: Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b"
xref: Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b"
@@ -39570,8 +39688,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54]
comment: This term was made obsolete because it represents a gene product.
synonym: "gamma-renin activity" EXACT []
-xref: EC:3.4.21.54
-xref: MetaCyc:3.4.21.54-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39585,8 +39701,6 @@ synonym: "acylaminoacyl-peptidase activity" EXACT []
synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1]
synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1]
synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1]
-xref: EC:3.4.19.1
-xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39610,8 +39724,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin G activity" EXACT []
synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20]
synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20]
-xref: EC:3.4.21.20
-xref: MetaCyc:3.4.21.20-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39627,8 +39739,6 @@ synonym: "cerevisin activity" EXACT []
synonym: "peptidase beta" RELATED [EC:3.4.21.48]
synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48]
synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48]
-xref: EC:3.4.21.48
-xref: MetaCyc:3.4.21.48-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39652,8 +39762,6 @@ synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1]
synonym: "enzeon" RELATED [EC:3.4.21.1]
synonym: "quimar" RELATED [EC:3.4.21.1]
synonym: "quimotrase activity" EXACT [EC:3.4.21.1]
-xref: EC:3.4.21.1
-xref: MetaCyc:3.4.21.1-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39699,8 +39807,6 @@ def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsin
comment: This term was made obsolete because it represents a gene product.
synonym: "enterokinase activity" RELATED [EC:3.4.21.9]
synonym: "enteropeptidase activity" EXACT []
-xref: EC:3.4.21.9
-xref: MetaCyc:3.4.21.9-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39719,8 +39825,6 @@ synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.
synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75]
synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75]
synonym: "SPC3" RELATED [EC:3.4.21.75]
-xref: EC:3.4.21.75
-xref: MetaCyc:3.4.21.75-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39738,8 +39842,6 @@ synonym: "HuTPS" RELATED [EC:3.4.21.78]
synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78]
synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78]
synonym: "TSP-1" RELATED [EC:3.4.21.78]
-xref: EC:3.4.21.78
-xref: MetaCyc:3.4.21.78-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39757,8 +39859,6 @@ synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79]
synonym: "granzyme B activity" EXACT []
synonym: "granzyme G" RELATED [EC:3.4.21.79]
synonym: "granzyme H" RELATED [EC:3.4.21.79]
-xref: EC:3.4.21.79
-xref: MetaCyc:3.4.21.79-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39770,8 +39870,6 @@ def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and P
comment: This term was made obsolete because it represents a gene product.
synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71]
synonym: "pancreatic elastase II activity" EXACT []
-xref: EC:3.4.21.71
-xref: MetaCyc:3.4.21.71-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39787,8 +39885,6 @@ synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7]
synonym: "plasmin activity" EXACT []
synonym: "serum tryptase activity" EXACT [EC:3.4.21.7]
synonym: "thrombolysin" RELATED [EC:3.4.21.7]
-xref: EC:3.4.21.7
-xref: MetaCyc:3.4.21.7-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39806,8 +39902,6 @@ synonym: "acrozonase activity" EXACT [EC:3.4.21.10]
synonym: "alpha-acrosin" RELATED [EC:3.4.21.10]
synonym: "beta-acrosin" RELATED [EC:3.4.21.10]
synonym: "psi-acrosin" RELATED [EC:3.4.21.10]
-xref: EC:3.4.21.10
-xref: MetaCyc:3.4.21.10-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39823,8 +39917,6 @@ synonym: "PC1 activity" NARROW [EC:3.4.21.93]
synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93]
synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93]
synonym: "proprotein convertase 1 activity" EXACT []
-xref: EC:3.4.21.93
-xref: MetaCyc:3.4.21.93-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39839,8 +39931,6 @@ synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94]
synonym: "PC2 activity" NARROW [EC:3.4.21.94]
synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94]
synonym: "proprotein convertase 2 activity" EXACT []
-xref: EC:3.4.21.94
-xref: MetaCyc:3.4.21.94-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39857,8 +39947,6 @@ synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "prolyl oligopeptidase activity" EXACT []
-xref: EC:3.4.21.26
-xref: MetaCyc:3.4.21.26-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39869,7 +39957,6 @@ namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "subtilase activity" EXACT []
-xref: EC:3.4.21
is_obsolete: true
replaced_by: GO:0004252
@@ -39900,8 +39987,6 @@ synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61]
synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61]
synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61]
synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61]
-xref: EC:3.4.21.61
-xref: MetaCyc:3.4.21.61-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39950,8 +40035,6 @@ synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62]
synonym: "superase activity" EXACT [EC:3.4.21.62]
synonym: "thermoase" BROAD [EC:3.4.21.62]
synonym: "thermoase PC 10" RELATED [EC:3.4.21.62]
-xref: EC:3.4.21.62
-xref: MetaCyc:3.4.21.62-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -39983,8 +40066,6 @@ synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35]
synonym: "tissue kallikrein activity" EXACT []
synonym: "urinary kallikrein" RELATED [EC:3.4.21.35]
synonym: "urokallikrein" RELATED [EC:3.4.21.35]
-xref: EC:3.4.21.35
-xref: MetaCyc:3.4.21.35-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -40000,8 +40081,6 @@ synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10]
synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10]
synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10]
synonym: "tripeptidyl-peptidase II activity" EXACT []
-xref: EC:3.4.14.10
-xref: MetaCyc:3.4.14.10-RXN
is_obsolete: true
replaced_by: GO:0008240
@@ -40022,8 +40101,6 @@ synonym: "tripcellim" RELATED [EC:3.4.21.4]
synonym: "trypsin activity" EXACT []
synonym: "tryptar" RELATED [EC:3.4.21.4]
synonym: "trypure" RELATED [EC:3.4.21.4]
-xref: EC:3.4.21.4
-xref: MetaCyc:3.4.21.4-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -40092,7 +40169,7 @@ synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17]
xref: EC:4.2.1.17
xref: MetaCyc:ENOYL-COA-HYDRAT-RXN
xref: Reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA"
-xref: Reactome:R-HSA-70870 "methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA"
+xref: Reactome:R-HSA-70870 "ECHS1 hydrates methacrylyl-CoA"
xref: Reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA"
xref: Reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA"
xref: Reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA"
@@ -40134,6 +40211,7 @@ xref: Reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to Ma
xref: Reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA"
xref: Reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA"
xref: Reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA"
+xref: RHEA:19037
xref: UM-BBD_enzymeID:e0397
is_a: GO:0016803 ! ether hydrolase activity
@@ -40267,6 +40345,7 @@ synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11]
synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11]
xref: EC:3.6.1.11
xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN
+xref: RHEA:21528
is_a: GO:0016462 ! pyrophosphatase activity
[Term]
@@ -40312,6 +40391,7 @@ synonym: "fatty-acid synthase activity" EXACT []
xref: EC:2.3.1.85
xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN
xref: Reactome:R-HSA-75872 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O"
+xref: RHEA:14993
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -40331,6 +40411,7 @@ synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38]
xref: EC:2.3.1.38
xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN
+xref: RHEA:41788
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0016418 ! S-acetyltransferase activity
@@ -40392,6 +40473,7 @@ synonym: "KASI" RELATED [EC:2.3.1.41]
synonym: "ketoacyl-ACP synthase activity" EXACT []
xref: EC:2.3.1.41
xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN
+xref: RHEA:22836
is_a: GO:0004312 ! fatty acid synthase activity
[Term]
@@ -40415,6 +40497,7 @@ synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT
xref: EC:1.1.1.100
xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN
xref: Reactome:R-HSA-8862152 "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP"
+xref: RHEA:17397
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -40488,6 +40571,7 @@ synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14]
xref: EC:3.1.2.14
xref: MetaCyc:3.1.2.14-RXN
xref: MetaCyc:PWY-5142
+xref: RHEA:15057
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity
[Term]
@@ -40500,6 +40584,7 @@ synonym: "fatty acyl CoA synthase activity" EXACT []
synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86]
xref: EC:2.3.1.86
xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN
+xref: RHEA:22896
is_a: GO:0016408 ! C-acyltransferase activity
[Term]
@@ -40557,6 +40642,7 @@ synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reduct
synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2]
xref: EC:1.18.1.2
xref: MetaCyc:1.18.1.2-RXN
+xref: RHEA:20125
is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity
[Term]
@@ -40603,6 +40689,7 @@ xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN
xref: Reactome:R-HSA-197958 "Conversion of cytosolic THF to THF-polyglutamate"
xref: Reactome:R-HSA-200681 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate"
xref: Reactome:R-HSA-200682 "Conversion of mitochondrial THF to THF-polyglutamate"
+xref: RHEA:10580
is_a: GO:0016881 ! acid-amino acid ligase activity
relationship: part_of GO:0046901 ! tetrahydrofolylpolyglutamate biosynthetic process
@@ -41073,7 +41160,7 @@ synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15]
xref: EC:4.1.1.15
xref: MetaCyc:GLUTDECARBOX-RXN
-xref: Reactome:R-HSA-888572 "Synthesis of GABA by GAD1"
+xref: Reactome:R-HSA-888572 "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA"
xref: Reactome:R-HSA-888577 "Synthesis of GABA by GAD2"
xref: RHEA:17785
is_a: GO:0016831 ! carboxy-lyase activity
@@ -41510,7 +41597,7 @@ xref: EC:2.1.2.1
xref: MetaCyc:GLYOHMETRANS-RXN
xref: Reactome:R-HSA-200651 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine"
xref: Reactome:R-HSA-200735 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine"
-xref: Reactome:R-HSA-5694137 "SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine"
+xref: Reactome:R-HSA-5694137 "PXLP-K280-SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine"
xref: Reactome:R-HSA-71249 "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly"
xref: RHEA:15481
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity
@@ -41520,7 +41607,7 @@ id: GO:0004373
name: glycogen (starch) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11]
-synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11]
+synonym: "glycogen (starch) synthetase activity" EXACT []
synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11]
synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11]
synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11]
@@ -41535,6 +41622,7 @@ xref: Reactome:R-HSA-3322009 "GYS2 catalyzes the polyglucosylation of oligoGlc-G
xref: Reactome:R-HSA-3322041 "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1"
xref: Reactome:R-HSA-3828061 "Defective GYS1 does not transfer glucose to growing glycogen chains"
xref: Reactome:R-HSA-3858506 "Defective GYS2 does not transfer glucose to growing glycogen chains"
+xref: RHEA:18549
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -41563,7 +41651,8 @@ synonym: "P-protein" NARROW [EC:1.4.4.2]
synonym: "protein P1" NARROW [EC:1.4.4.2]
xref: EC:1.4.4.2
xref: MetaCyc:GCVP-RXN
-xref: Reactome:R-HSA-5693967 "GLDC dimer:2xPXLP decarboxylates Gly"
+xref: Reactome:R-HSA-5693967 "PXLP-K754-GLDC dimer decarboxylates Gly"
+xref: RHEA:24304
is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
[Term]
@@ -41628,6 +41717,7 @@ xref: EC:2.3.1.97
xref: MetaCyc:2.3.1.97-RXN
xref: Reactome:R-HSA-184392 "N-myristoylation of GAG polyprotein by NMT2"
xref: Reactome:R-HSA-2534087 "NMT1/2 transfer MYS to GNAT1"
+xref: RHEA:15521
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0019107 ! myristoyltransferase activity
@@ -41654,6 +41744,7 @@ xref: EC:2.4.1.40
xref: MetaCyc:2.4.1.40-RXN
xref: Reactome:R-HSA-9033959 "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC"
xref: Reactome:R-HSA-9034042 "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec"
+xref: RHEA:19021
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein
@@ -41768,15 +41859,10 @@ subset: goslim_generic
subset: goslim_pir
subset: goslim_yeast
synonym: "ATP-dependent helicase activity" EXACT []
-xref: Reactome:R-HSA-167097 "HIV Promoter Opening: First Transition"
xref: Reactome:R-HSA-169461 "MCM8 mediated fork unwinding"
xref: Reactome:R-HSA-169468 "MCM2-7 mediated fork unwinding"
+xref: Reactome:R-HSA-5686410 "BLM mediates dissolution of double Holliday junction"
xref: Reactome:R-HSA-5690996 "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA"
-xref: Reactome:R-HSA-75949 "RNA Polymerase II Promoter Opening: First Transition"
-xref: Reactome:R-HSA-9613490 "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition"
-xref: Reactome:R-HSA-9613494 "Unwinding of DNA for the Nascent Transcript: Second Transition"
-xref: Reactome:R-HSA-9613497 "Unwinding DNA for the nascent transcript"
-xref: Reactome:R-HSA-9613498 "Unwinding of DNA for the nascent HIV-1 transcript"
is_a: GO:0016887 ! ATPase activity
[Term]
@@ -41964,6 +42050,7 @@ xref: Reactome:R-HSA-3697008 "CREBBP acetylates histone H2B, H3, H4"
xref: Reactome:R-HSA-3697920 "CLOCK acetylates lysine-10 of histone H3, H4"
xref: Reactome:R-HSA-5144542 "CLOCK acetylates lysine-15 of histone H3, H4"
xref: Reactome:R-HSA-5250938 "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9"
+xref: RHEA:21992
is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity
relationship: part_of GO:0016573 ! histone acetylation
@@ -41983,6 +42070,7 @@ xref: Reactome:R-HSA-3782655 "HDAC10 deacetylates histone"
xref: Reactome:R-HSA-427514 "eNoSC deacetylates histone H3"
xref: Reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3"
xref: Reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53"
+xref: RHEA:58196
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0033558 ! protein deacetylase activity
relationship: part_of GO:0016575 ! histone deacetylation
@@ -41999,6 +42087,7 @@ synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1
synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17]
xref: EC:4.4.1.17
xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN
+xref: RHEA:22648
is_a: GO:0016846 ! carbon-sulfur lyase activity
[Term]
@@ -42772,6 +42861,7 @@ synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86]
xref: EC:1.1.1.86
xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN
+xref: RHEA:22068
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -42813,6 +42903,7 @@ synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4]
synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4]
xref: EC:1.1.2.4
xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
+xref: RHEA:13521
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
@@ -42851,6 +42942,7 @@ synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3]
synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3]
xref: EC:1.1.2.3
xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
+xref: RHEA:19909
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
@@ -43222,6 +43314,7 @@ synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylas
xref: EC:2.1.2.9
xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN
xref: Reactome:R-HSA-5389841 "MTFMT formylates methionyl-tRNA"
+xref: RHEA:24380
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
relationship: part_of GO:0006413 ! translational initiation
@@ -43237,6 +43330,7 @@ synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (me
synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16]
xref: EC:2.1.1.16
xref: MetaCyc:2.1.1.16-RXN
+xref: RHEA:17549
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -43252,6 +43346,9 @@ synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity"
xref: EC:2.1.1.56
xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase"
+xref: Reactome:R-HSA-9684016 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs"
+xref: Reactome:R-HSA-9684017 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)"
+xref: Reactome:R-HSA-9684018 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008174 ! mRNA methyltransferase activity
relationship: part_of GO:0006370 ! 7-methylguanosine mRNA capping
@@ -43268,6 +43365,9 @@ synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57]
synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57]
xref: EC:2.1.1.57
xref: MetaCyc:2.1.1.57-RXN
+xref: Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)"
+xref: Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)"
+xref: Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs"
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008174 ! mRNA methyltransferase activity
@@ -43285,6 +43385,7 @@ xref: EC:2.7.7.50
xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN
xref: Reactome:R-HSA-77081 "Formation of the CE:GMP intermediate complex"
xref: Reactome:R-HSA-77083 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA"
+xref: RHEA:54592
is_a: GO:0008192 ! RNA guanylyltransferase activity
[Term]
@@ -43743,6 +43844,7 @@ synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXA
synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3]
xref: EC:1.14.17.3
xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN
+xref: RHEA:21452
is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
[Term]
@@ -43758,7 +43860,7 @@ synonym: "phenylalanine hydroxylase activity" EXACT []
xref: EC:1.14.16.1
xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-5649483 "Defective PAH does not hydroxylate L-Phe to L-Tyr"
-xref: Reactome:R-HSA-71118 "PAH tetramer hydroxylates L-Phe to L-Tyr"
+xref: Reactome:R-HSA-71118 "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr"
xref: RHEA:20273
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
@@ -43802,6 +43904,7 @@ xref: Reactome:R-HSA-193997 "CYP11B1 oxidises 11DCORT"
xref: Reactome:R-HSA-194017 "CYP11B2 oxidises 11DCORST to CORST"
xref: Reactome:R-HSA-5580292 "Defective CYP11B1 does not oxidise 11DCORT"
xref: Reactome:R-HSA-5600598 "Defective CYP11B2 does not oxidise 11DCORST"
+xref: RHEA:15629
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
@@ -43913,6 +44016,7 @@ synonym: "SAT-3" RELATED [EC:2.4.99.10]
synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10]
xref: EC:2.4.99.10
xref: MetaCyc:2.4.99.10-RXN
+xref: RHEA:18913
is_a: GO:0008373 ! sialyltransferase activity
[Term]
@@ -44145,8 +44249,6 @@ synonym: "tRNA 5' leader endonuclease activity" EXACT []
xref: EC:3.1.26.5
xref: MetaCyc:3.1.26.5-RXN
xref: Reactome:R-HSA-5696810 "RNase P cleaves the 5' end of pre-tRNA"
-xref: Reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript"
-xref: Reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript"
xref: Wikipedia:RNase_P
is_a: GO:0004549 ! tRNA-specific ribonuclease activity
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters
@@ -44381,6 +44483,7 @@ synonym: "O-glucosyl hydrolase activity" EXACT []
xref: EC:3.2.1
xref: Reactome:R-HSA-5694563 "ABHD10 hydrolyses MPAG"
xref: Reactome:R-HSA-6786652 "CHIT1 hydrolyses CHIT to 3xADGP"
+xref: Reactome:R-HSA-9661820 "Bacterial GUSB hydrolyses BDG to BIL"
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds
[Term]
@@ -44426,6 +44529,7 @@ synonym: "melibiase activity" EXACT []
xref: EC:3.2.1.22
xref: MetaCyc:ALPHAGALACTOSID-RXN
xref: Reactome:R-HSA-1605736 "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers"
+xref: RHEA:28663
is_a: GO:0015925 ! galactosidase activity
[Term]
@@ -44488,6 +44592,7 @@ synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51]
xref: EC:3.2.1.51
xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN
xref: Reactome:R-HSA-5693807 "FUCA1 hydrolyses NGP:1,6-GlcNAc"
+xref: RHEA:12288
is_a: GO:0015928 ! fucosidase activity
[Term]
@@ -44613,6 +44718,7 @@ xref: Reactome:R-HSA-2162227 "GUSB tetramer hydrolyses (HA)2"
xref: Reactome:R-HSA-2318373 "Defective GUSB does not hydrolyse (HA)2"
xref: Reactome:R-HSA-9036068 "Defective GUSB does not hydrolyse GlcA-1,3-GlcNAc"
xref: Reactome:R-HSA-9036070 "Defective GUSB does not hydrolyse CS/HS precursor"
+xref: RHEA:17633
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -44659,6 +44765,7 @@ synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130]
xref: EC:3.2.1.130
xref: MetaCyc:3.2.1.130-RXN
xref: Reactome:R-HSA-964759 "Alternative endo-mannosidase I route"
+xref: RHEA:54824
is_a: GO:0004559 ! alpha-mannosidase activity
[Term]
@@ -44715,6 +44822,7 @@ synonym: "mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity" EXACT []
xref: EC:3.2.1.114
xref: MetaCyc:3.2.1.114-RXN
xref: Reactome:R-HSA-975814 "Trimming of mannoses on the alpha1,6 arm by MAN2A1"
+xref: RHEA:56052
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity
[Term]
@@ -44731,6 +44839,7 @@ xref: EC:3.2.1.106
xref: MetaCyc:3.2.1.106-RXN
xref: Reactome:R-HSA-4793947 "Defective MOGS does not cleave glucose from an N-glycosylated protein"
xref: Reactome:R-HSA-532678 "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase"
+xref: RHEA:55988
is_a: GO:0015926 ! glucosidase activity
[Term]
@@ -44772,6 +44881,7 @@ xref: KEGG_REACTION:R00802
xref: MetaCyc:RXN-1461
xref: Reactome:R-HSA-189069 "sucrose + H2O => glucose + fructose"
xref: Reactome:R-HSA-5659926 "Defective SI does not hydrolyze Suc"
+xref: RHEA:33795
is_a: GO:0004564 ! beta-fructofuranosidase activity
is_a: GO:0090599 ! alpha-glucosidase activity
@@ -44796,6 +44906,7 @@ xref: EC:2.4.1.141
xref: MetaCyc:2.4.1.141-RXN
xref: Reactome:R-HSA-446207 "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP"
xref: Reactome:R-HSA-5633241 "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP"
+xref: RHEA:23380
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
[Term]
@@ -44810,6 +44921,7 @@ xref: EC:2.4.1.142
xref: MetaCyc:2.4.1.142-RXN
xref: Reactome:R-HSA-446218 "Addition of the first mannose to the N-glycan precursor by ALG1"
xref: Reactome:R-HSA-4549382 "Defective ALG1 does not transfer the first Man to the N-glycan precursor"
+xref: RHEA:13865
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity
[Term]
@@ -44980,6 +45092,7 @@ xref: EC:2.6.1.13
xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-70654 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]"
xref: Reactome:R-HSA-70666 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]"
+xref: RHEA:13877
is_a: GO:0008483 ! transaminase activity
[Term]
@@ -45073,6 +45186,7 @@ synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT []
synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
xref: EC:1.2.4.2
xref: MetaCyc:2OXOGLUTDECARB-RXN
+xref: RHEA:12188
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
[Term]
@@ -45189,6 +45303,7 @@ synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5
synonym: "PGL" RELATED [EC:4.3.2.5]
xref: EC:4.3.2.5
xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN
+xref: RHEA:20924
is_a: GO:0016842 ! amidine-lyase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -45295,6 +45410,7 @@ synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activit
xref: EC:2.1.1.28
xref: MetaCyc:2.1.1.28-RXN
xref: Reactome:R-HSA-209903 "Noradrenaline is converted to adrenaline"
+xref: RHEA:12176
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
@@ -45361,6 +45477,7 @@ synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43
xref: EC:2.3.1.43
xref: MetaCyc:2.3.1.43-RXN
xref: Reactome:R-HSA-264695 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)"
+xref: RHEA:21204
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -45546,7 +45663,7 @@ synonym: "SerA" RELATED [EC:1.1.1.95]
synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95]
xref: EC:1.1.1.95
xref: MetaCyc:PGLYCDEHYDROG-RXN
-xref: Reactome:R-HSA-977348 "3-phosphoglycerate is dehydrogenated"
+xref: Reactome:R-HSA-977348 "PHGHD tetramer dehydrogenates 3PG"
xref: RHEA:12641
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -45574,7 +45691,7 @@ xref: EC:2.7.2.3
xref: KEGG_REACTION:R01512
xref: MetaCyc:PHOSGLYPHOS-RXN
xref: Reactome:R-HSA-70486 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate"
-xref: Reactome:R-HSA-71850 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP"
+xref: Reactome:R-HSA-71850 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP"
xref: RHEA:14801
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
@@ -45798,6 +45915,7 @@ xref: MetaCyc:PHOSCHOL-RXN
xref: Reactome:R-HSA-1483142 "PC is transphosphatidylated to PG by PLD1-4/6"
xref: Reactome:R-HSA-1483182 "PC is hydrolyzed to PA and choline by PLD1/2"
xref: Reactome:R-HSA-2029471 "Hydrolysis of PC to PA by PLD"
+xref: RHEA:14445
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity
@@ -45831,6 +45949,7 @@ synonym: "phosphopantothenoylcysteine synthetase activity" EXACT []
xref: EC:6.3.2.5
xref: MetaCyc:P-PANTOCYSLIG-RXN
xref: Reactome:R-HSA-196753 "2xPPCS ligates PPanK with Cys"
+xref: RHEA:19397
is_a: GO:0016881 ! acid-amino acid ligase activity
[Term]
@@ -46099,7 +46218,7 @@ def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine
synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3]
xref: EC:3.1.3.3
xref: MetaCyc:PSERPHOSPHA-RXN
-xref: Reactome:R-HSA-977324 "phosphoserine is dephosphorylated"
+xref: Reactome:R-HSA-977324 "PSPH:Mg2+ dimer dephosphorylates O-P-Ser"
is_a: GO:0016791 ! phosphatase activity
[Term]
@@ -46122,7 +46241,7 @@ synonym: "PSAT activity" EXACT [EC:2.6.1.52]
synonym: "SerC" RELATED [EC:2.6.1.52]
xref: EC:2.6.1.52
xref: MetaCyc:PSERTRANSAM-RXN
-xref: Reactome:R-HSA-977333 "3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate"
+xref: Reactome:R-HSA-977333 "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA"
xref: RHEA:14329
is_a: GO:0008483 ! transaminase activity
@@ -46135,6 +46254,7 @@ xref: EC:3.2.1.143
xref: MetaCyc:3.2.1.143-RXN
xref: Reactome:R-HSA-5651828 "PARG dePARylates PARP1,PARP2"
xref: Reactome:R-HSA-8952903 "ADPRHL2 hydrolyses poly(ADP-ribose)"
+xref: RHEA:52216
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -46168,6 +46288,7 @@ synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33]
xref: EC:3.1.3.33
xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN
xref: Reactome:R-HSA-77078 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme"
+xref: RHEA:11008
is_a: GO:0098518 ! polynucleotide phosphatase activity
relationship: part_of GO:0098507 ! polynucleotide 5' dephosphorylation
@@ -46197,6 +46318,7 @@ synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19]
xref: EC:2.7.7.19
xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN
xref: Reactome:R-HSA-72185 "mRNA polyadenylation"
+xref: RHEA:11332
is_a: GO:0070566 ! adenylyltransferase activity
[Term]
@@ -46225,6 +46347,7 @@ xref: Reactome:R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to muci
xref: Reactome:R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins"
xref: Reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23"
xref: Reactome:R-HSA-913675 "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens"
+xref: Reactome:R-HSA-9683760 "GalNAc is transferred onto 3a"
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -46239,6 +46362,7 @@ synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8]
synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8]
xref: EC:2.7.7.8
xref: MetaCyc:2.7.7.8-RXN
+xref: RHEA:22096
is_a: GO:0016779 ! nucleotidyltransferase activity
[Term]
@@ -46290,6 +46414,7 @@ xref: EC:1.14.11.2
xref: KEGG_REACTION:R03219
xref: MetaCyc:1.14.11.2-RXN
xref: Reactome:R-HSA-1650808 "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines"
+xref: RHEA:18945
is_a: GO:0019798 ! procollagen-proline dioxygenase activity
is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity
@@ -46346,6 +46471,8 @@ synonym: "protein-cysteine farnesyltransferase activity" EXACT []
xref: EC:2.5.1.58
xref: MetaCyc:2.5.1.58-RXN
xref: Reactome:R-HSA-2530501 "FNTA:FNTB transfers FARN to GNGT1"
+xref: Reactome:R-HSA-9647978 "pro-RAS proteins are farnesylated"
+xref: RHEA:13345
is_a: GO:0008318 ! protein prenyltransferase activity
[Term]
@@ -46465,6 +46592,7 @@ xref: EC:3.5.3.15
xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN
xref: Reactome:R-HSA-1183128 "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins"
xref: Reactome:R-HSA-3247569 "PADI4 deiminates Histones"
+xref: RHEA:18089
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18666 xsd:anyURI
@@ -46494,6 +46622,8 @@ xref: EC:2.1.1.100
xref: KEGG_REACTION:R04496
xref: MetaCyc:2.1.1.100-RXN
xref: Reactome:R-HSA-6788650 "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins"
+xref: Reactome:R-HSA-9647977 "ICMT methylates S-Farn RAS proteins"
+xref: RHEA:21672
is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
@@ -46511,6 +46641,7 @@ xref: MetaCyc:PROTEIN-KINASE-RXN
xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a"
xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino"
xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4"
+xref: Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation"
xref: Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
@@ -46561,6 +46692,7 @@ synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1]
synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1]
synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1]
+xref: EC:2.7.11
xref: Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2"
xref: Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1"
xref: Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2"
@@ -46588,14 +46720,14 @@ xref: Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2"
xref: Reactome:R-HSA-1549526 "Phosphorylation of SMAD2/3 by Activin:Activin Receptor"
xref: Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation"
xref: Reactome:R-HSA-156678 "Activation of Cdc25C"
-xref: Reactome:R-HSA-156682 "Regulation of NUDC by phosphorylation"
+xref: Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC"
xref: Reactome:R-HSA-156699 "Inactivation of Wee1 kinase"
xref: Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation"
xref: Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A"
xref: Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B"
xref: Reactome:R-HSA-162657 "Inactivation of Myt1 kinase"
xref: Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1"
-xref: Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:Beclin-1 complex"
+xref: Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex"
xref: Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP"
xref: Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP"
xref: Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres"
@@ -46844,7 +46976,7 @@ xref: Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA"
xref: Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A"
xref: Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs"
xref: Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated"
-xref: Reactome:R-HSA-5672010 "Active mTORC1 phosphorylates ULK1"
+xref: Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1"
xref: Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1"
xref: Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1"
xref: Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs"
@@ -46923,7 +47055,6 @@ xref: Reactome:R-HSA-6805785 "AKT phosphorylates PHF20"
xref: Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter"
xref: Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A"
xref: Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL"
-xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine"
xref: Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1"
xref: Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2"
xref: Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53"
@@ -46944,6 +47075,7 @@ xref: Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B"
xref: Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C"
xref: Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A"
xref: Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23"
+xref: Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3"
xref: Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2"
xref: Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1"
xref: Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A"
@@ -46984,7 +47116,13 @@ xref: Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4
xref: Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP"
xref: Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex"
xref: Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4"
+xref: Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF"
+xref: Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF"
+xref: Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF"
+xref: Reactome:R-HSA-9612501 "SGK phosphorylates CREB1"
+xref: Reactome:R-HSA-9612509 "SGK phosphorylates SRF"
xref: Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates"
+xref: Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs"
xref: Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT"
xref: Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs"
xref: Reactome:R-HSA-9620004 "RSKs autophosphorylate"
@@ -46992,7 +47130,21 @@ xref: Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EG
xref: Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345"
xref: Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T125"
xref: Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen"
+xref: Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1"
+xref: Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates"
xref: Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2"
+xref: Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA"
+xref: Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4"
+xref: Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates"
+xref: Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)"
+xref: Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs"
+xref: Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181"
+xref: Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants"
+xref: Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer"
+xref: Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17"
+xref: Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL"
+xref: Reactome:R-HSA-9681627 "GSK3 phosphorylates N"
+xref: Reactome:R-HSA-9683664 "GSK3B phosphorylates Ncap"
xref: Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9"
xref: Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9"
xref: Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9"
@@ -47025,6 +47177,7 @@ xref: MetaCyc:2.7.11.30-RXN
xref: Reactome:R-HSA-170868 "Activated type I receptor phosphorylates SMAD2/3 directly"
xref: Reactome:R-HSA-198732 "STAT3 activation"
xref: Reactome:R-HSA-201476 "Activated type I receptor phosphorylates R-Smad1/5/8 directly"
+xref: RHEA:18673
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
@@ -47060,7 +47213,7 @@ xref: Reactome:R-HSA-163691 "Phosphorylation of ChREBP at Serine 568 by AMPK"
xref: Reactome:R-HSA-200423 "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis"
xref: Reactome:R-HSA-380927 "p-AMPK phosphorylates TSC1:TSC2"
xref: Reactome:R-HSA-447074 "AMPK phosphorylates Raptor in the mTORC1 complex"
-xref: Reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex"
+xref: Reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex"
xref: Reactome:R-HSA-6805470 "AMPK phosphorylates TP53"
is_a: GO:0004674 ! protein serine/threonine kinase activity
relationship: has_part GO:0016208 ! AMP binding
@@ -47072,7 +47225,6 @@ namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "casein kinase activity" EXACT []
-xref: EC:2.7.11
is_obsolete: true
replaced_by: GO:0004674
@@ -47083,7 +47235,6 @@ namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "casein kinase I activity" EXACT []
-xref: EC:2.7.11
is_obsolete: true
replaced_by: GO:0004674
@@ -47173,6 +47324,7 @@ synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20]
synonym: "STK19" RELATED [EC:2.7.11.20]
xref: EC:2.7.11.20
xref: MetaCyc:2.7.11.20-RXN
+xref: RHEA:21436
is_a: GO:0004683 ! calmodulin-dependent protein kinase activity
[Term]
@@ -47198,6 +47350,7 @@ xref: EC:2.7.11.18
xref: MetaCyc:2.7.11.18-RXN
xref: Reactome:R-HSA-445813 "Phosphorylation of Smooth Muscle Myosin Light Chains"
xref: Reactome:R-HSA-5668978 "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex"
+xref: RHEA:22004
is_a: GO:0004674 ! protein serine/threonine kinase activity
[Term]
@@ -47325,7 +47478,7 @@ xref: Reactome:R-HSA-187520 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p2
xref: Reactome:R-HSA-187916 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21"
xref: Reactome:R-HSA-187948 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2"
xref: Reactome:R-HSA-187959 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)"
-xref: Reactome:R-HSA-188390 "Cyclin E:Cdk2-mediated phosphorylation of Rb"
+xref: Reactome:R-HSA-188390 "Cyclin E:CDK2-mediated phosphorylation of RB1"
xref: Reactome:R-HSA-1912391 "NICD1 is phosphorylated by CDK8"
xref: Reactome:R-HSA-2172183 "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB"
xref: Reactome:R-HSA-2220971 "CDK8 phosphorylates NICD1 PEST domain mutants"
@@ -47354,6 +47507,8 @@ xref: Reactome:R-HSA-69754 "Phosphorylation of proteins involved in G2/M transit
xref: Reactome:R-HSA-69756 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes"
xref: Reactome:R-HSA-9008412 "CDK4 phosphorylates RUNX2"
xref: Reactome:R-HSA-9009282 "CDK1 phosphorylates RUNX2"
+xref: Reactome:R-HSA-9624800 "CDK1 phosphorylates LBR"
+xref: Reactome:R-HSA-9686521 "CDK2:CCNA phosphorylates TERF2"
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0097472 ! cyclin-dependent protein kinase activity
@@ -47480,6 +47635,7 @@ synonym: "GRK5" RELATED [EC:2.7.11.16]
synonym: "GRK6" RELATED [EC:2.7.11.16]
synonym: "STK16" RELATED [EC:2.7.11.16]
xref: EC:2.7.11.16
+xref: RHEA:12008
is_a: GO:0004674 ! protein serine/threonine kinase activity
[Term]
@@ -47504,6 +47660,7 @@ xref: Reactome:R-HSA-168136 "Activated JNKs phosphorylate c-JUN"
xref: Reactome:R-HSA-204949 "NRIF and TRAF6 may activate JNK"
xref: Reactome:R-HSA-205075 "JNK phosphorylates BIM, BAD and other targets"
xref: Reactome:R-HSA-205132 "NRAGE activates JNK"
+xref: Reactome:R-HSA-9673789 "Activated JNK phosphorylates c-JUN"
is_a: GO:0004707 ! MAP kinase activity
relationship: part_of GO:0007258 ! JUN phosphorylation
@@ -47667,6 +47824,7 @@ xref: Reactome:R-HSA-6802922 "Activated MAP2Ks phosphorylate MAPKs downstream of
xref: Reactome:R-HSA-6802924 "RAF is phosphorylated downstream of oncogenic RAS"
xref: Reactome:R-HSA-6802927 "BRAF and RAF fusion mutant dimers are phosphorylated"
xref: Reactome:R-HSA-6802941 "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF"
+xref: Reactome:R-HSA-9656212 "Phosphorylation of RAF1 mutants"
is_a: GO:0004672 ! protein kinase activity
[Term]
@@ -47687,6 +47845,7 @@ xref: Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-
xref: Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants"
xref: Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants"
xref: Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers"
+xref: Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer"
xref: Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers"
xref: Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers"
xref: Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers"
@@ -47700,6 +47859,7 @@ xref: Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs"
xref: Reactome:R-HSA-1433506 "Phosphorylation of APS"
xref: Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1"
xref: Reactome:R-HSA-1470009 "Phosphorylation of STATs"
+xref: Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases"
xref: Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR"
xref: Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated"
xref: Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes"
@@ -47763,7 +47923,7 @@ xref: Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src"
xref: Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2"
xref: Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation"
xref: Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs"
-xref: Reactome:R-HSA-2197698 "Phosphorylation of WASP/N-WASP"
+xref: Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP"
xref: Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK"
xref: Reactome:R-HSA-2395412 "Phosphorylation of SYK"
xref: Reactome:R-HSA-2395439 "Phosphorylation of DAP12"
@@ -47988,6 +48148,7 @@ xref: Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2"
xref: Reactome:R-HSA-909732 "Phosphorylation of STAT2"
xref: Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated"
xref: Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation"
+xref: Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates"
xref: Reactome:R-HSA-9606159 "BTK autophosphorylates"
xref: Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2"
xref: Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK"
@@ -47995,6 +48156,28 @@ xref: Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDAR
xref: Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates"
xref: Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates"
xref: Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR"
+xref: Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1"
+xref: Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK"
+xref: Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers"
+xref: Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect"
+xref: Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate"
+xref: Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1"
+xref: Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1"
+xref: Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate"
+xref: Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1"
+xref: Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1"
+xref: Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1"
+xref: Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate"
+xref: Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3"
+xref: Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants"
+xref: Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants"
+xref: Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants"
+xref: Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants"
+xref: Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers"
+xref: Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers"
+xref: Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins"
+xref: Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB"
+xref: Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants"
xref: Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR"
xref: Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)"
xref: Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR"
@@ -48067,6 +48250,7 @@ xref: Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylat
xref: Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3"
xref: Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2"
xref: Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3"
+xref: RHEA:10596
is_a: GO:0004713 ! protein tyrosine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity
@@ -48149,6 +48333,7 @@ synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase act
xref: EC:2.1.1.77
xref: MetaCyc:2.1.1.77-RXN
xref: Reactome:R-HSA-5676966 "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp"
+xref: RHEA:12705
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity
@@ -48165,6 +48350,7 @@ xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN
xref: Reactome:R-HSA-2002466 "Formation of allysine by LOX"
xref: Reactome:R-HSA-2129375 "Elastin cross-linking by lysyl oxidase"
xref: Reactome:R-HSA-2395340 "Formation of hydroxyallysine by LOX"
+xref: RHEA:24544
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -48194,6 +48380,7 @@ xref: Reactome:R-HSA-174124 "Dephosphorylation of phospho-Cdh1"
xref: Reactome:R-HSA-178178 "PP1 dephosphorylates TGFBR1"
xref: Reactome:R-HSA-2529015 "Dephosphorylation of CK2-modified condensin I"
xref: Reactome:R-HSA-69199 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A"
+xref: Reactome:R-HSA-9636684 "ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP"
is_a: GO:0016791 ! phosphatase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
relationship: part_of GO:0006470 ! protein dephosphorylation
@@ -48272,12 +48459,15 @@ xref: Reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH"
xref: Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24"
xref: Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2"
xref: Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma"
-xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine"
xref: Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO"
xref: Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5"
xref: Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4"
xref: Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII"
xref: Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1"
+xref: Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs"
+xref: Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex"
+xref: Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs"
+xref: Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2"
is_a: GO:0004721 ! phosphoprotein phosphatase activity
[Term]
@@ -48344,13 +48534,17 @@ xref: Reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1148 (Y1172)"
xref: Reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021"
xref: Reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248"
xref: Reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15"
+xref: Reactome:R-HSA-8867658 "PTPN3 dephosphorylates MAPK12"
xref: Reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1"
xref: Reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB"
xref: Reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3"
+xref: Reactome:R-HSA-9635461 "PtpA dephosphorylates GSK3A"
+xref: Reactome:R-HSA-9636439 "PtpA:Ub dephosphorylates p-Y133-VPS33B"
xref: Reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2"
xref: Reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B"
xref: Reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1"
xref: Reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP"
+xref: RHEA:10684
is_a: GO:0004721 ! phosphoprotein phosphatase activity
relationship: part_of GO:0035335 ! peptidyl-tyrosine dephosphorylation
@@ -48363,6 +48557,7 @@ xref: Reactome:R-HSA-177923 "Sustained activation of SRC kinase by SHP2"
xref: Reactome:R-HSA-177924 "Dephosphorylation of Gab1 by SHP2"
xref: Reactome:R-HSA-177926 "Dephosphorylation of PAG by SHP2"
xref: Reactome:R-HSA-177935 "SHP2 dephosphorylates Tyr 992 on EGFR"
+xref: Reactome:R-HSA-9635739 "PTPN7 dephosphorylates p-T,Y-MAPKs"
is_a: GO:0004725 ! protein tyrosine phosphatase activity
[Term]
@@ -48487,6 +48682,7 @@ synonym: "PDA synthase activity" EXACT [EC:1.5.4.1]
synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1]
xref: EC:1.5.4.1
xref: MetaCyc:1.5.4.1-RXN
+xref: RHEA:10720
is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor
[Term]
@@ -48561,6 +48757,7 @@ synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1]
synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1]
synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1]
xref: EC:1.2.4.1
+xref: RHEA:19189
is_a: GO:0004738 ! pyruvate dehydrogenase activity
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
@@ -48586,6 +48783,7 @@ synonym: "STK1" RELATED [EC:2.7.11.2]
xref: EC:2.7.11.2
xref: MetaCyc:2.7.11.2-RXN
xref: Reactome:R-HSA-203946 "PDK isoforms phosphorylate lipo-PDH"
+xref: RHEA:23052
is_a: GO:0004672 ! protein kinase activity
[Term]
@@ -48603,6 +48801,7 @@ synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43]
xref: EC:3.1.3.43
xref: MetaCyc:3.1.3.43-RXN
xref: Reactome:R-HSA-204169 "PDP dephosphorylates p-lipo-PDH"
+xref: RHEA:12669
is_a: GO:0004721 ! phosphoprotein phosphatase activity
[Term]
@@ -48641,7 +48840,7 @@ synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40]
synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40]
xref: EC:2.7.1.40
xref: MetaCyc:PEPDEPHOS-RXN
-xref: Reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP, Homo sapiens"
+xref: Reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP"
xref: RHEA:18159
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
relationship: part_of GO:0006096 ! glycolytic process
@@ -48889,6 +49088,7 @@ xref: EC:1.1.1.153
xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN
xref: Reactome:R-HSA-1475414 "PTHP is reduced to BH4 by sepiapterin reductase (SPR)"
xref: Reactome:R-HSA-1497869 "Salvage - Sepiapterin is reduced to BH2"
+xref: RHEA:18953
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -49022,6 +49222,7 @@ xref: EC:1.14.19.1
xref: MetaCyc:1.14.19.1-RXN
xref: Reactome:R-HSA-5690565 "SCD desaturates ST-CoA to OLE-CoA"
xref: Reactome:R-HSA-8847579 "SCD5 desaturates ST-CoA to OLE-CoA"
+xref: RHEA:19721
is_a: GO:0016215 ! acyl-CoA desaturase activity
[Term]
@@ -49051,6 +49252,7 @@ xref: Reactome:R-HSA-193073 "DHA isomerizes to 4-Androstene3,17-dione"
xref: Reactome:R-HSA-193961 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone"
xref: Reactome:R-HSA-195690 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol"
xref: Reactome:R-HSA-6807052 "EBP isomerizes ZYMSTNL to LTHSOL"
+xref: RHEA:14709
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds
[Term]
@@ -49075,6 +49277,7 @@ xref: MetaCyc:STEROL-ESTERASE-RXN
xref: Reactome:R-HSA-192417 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)"
xref: Reactome:R-HSA-6813720 "NCEH1 hydrolyzes cholesterol esters"
xref: Reactome:R-HSA-8865667 "LIPA hydrolyses sterol esters to sterols and fatty acids"
+xref: RHEA:10100
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity
@@ -49167,7 +49370,7 @@ id: GO:0004777
name: succinate-semialdehyde dehydrogenase (NAD+) activity
namespace: molecular_function
alt_id: GO:0008952
-def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24]
+def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [RHEA:13217]
synonym: "succinate semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24]
synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24]
synonym: "succinate-semialdehyde dehydrogenase activity" BROAD [GOC:bf]
@@ -49176,7 +49379,7 @@ synonym: "succinic semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24]
synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24]
xref: EC:1.2.1.24
xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
-xref: Reactome:R-HSA-888548 "Conversion of succinate semialdehyde to succinate"
+xref: Reactome:R-HSA-888548 "ALDH5A1 dehydrogenates SUCCSA to SUCCA"
xref: RHEA:13217
is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity
@@ -49258,7 +49461,8 @@ synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "sulphinoalanine decarboxylase activity" EXACT []
xref: EC:4.1.1.29
xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN
-xref: Reactome:R-HSA-1655443 "CSAD decarboxylates 3-sulfinoalanine to hypotaurine"
+xref: Reactome:R-HSA-1655443 "PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine"
+xref: RHEA:16877
is_a: GO:0016831 ! carboxy-lyase activity
[Term]
@@ -49624,6 +49828,7 @@ xref: Reactome:R-HSA-163741 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phos
xref: Reactome:R-HSA-163751 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate"
xref: Reactome:R-HSA-71324 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate"
xref: Reactome:R-HSA-71335 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate"
+xref: RHEA:10508
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups
[Term]
@@ -49740,6 +49945,7 @@ synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity
xref: EC:2.1.1.61
xref: KEGG_REACTION:R00601
xref: MetaCyc:2.1.1.61-RXN
+xref: RHEA:19569
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
@@ -49907,6 +50113,7 @@ xref: EC:6.1.1.16
xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-379887 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380158 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate"
+xref: RHEA:17773
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity
[Term]
@@ -50038,6 +50245,7 @@ xref: EC:6.1.1.6
xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN
xref: Reactome:R-HSA-380008 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate"
xref: Reactome:R-HSA-380233 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate"
+xref: RHEA:20792
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity
[Term]
@@ -50263,6 +50471,7 @@ synonym: "tubulinyl-tyrosine ligase activity" EXACT []
xref: EC:6.3.2.25
xref: MetaCyc:6.3.2.25-RXN
xref: Reactome:R-HSA-8955706 "TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin"
+xref: RHEA:17605
is_a: GO:0016881 ! acid-amino acid ligase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -50311,6 +50520,7 @@ xref: EC:2.6.1.5
xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN
xref: Reactome:R-HSA-517444 "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate"
xref: Reactome:R-HSA-71155 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate"
+xref: RHEA:15093
is_a: GO:0070547 ! L-tyrosine aminotransferase activity
[Term]
@@ -50455,7 +50665,9 @@ xref: Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and
xref: Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2"
xref: Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains"
xref: Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation"
-xref: Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation"
+xref: Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation"
+xref: Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer"
+xref: Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex"
xref: Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane"
xref: Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2"
xref: Reactome:R-HSA-983153 "E1 mediated ubiquitin activation"
@@ -50467,35 +50679,87 @@ relationship: part_of GO:0016567 ! protein ubiquitination
id: GO:0004843
name: thiol-dependent ubiquitin-specific protease activity
namespace: molecular_function
+alt_id: GO:0036459
def: "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein." [GOC:jh2, ISBN:0120793709]
synonym: "deubiquitinase" EXACT [GOC:vw, PMID:19261746]
synonym: "deubiquitinase activity" NARROW [GOC:bf]
synonym: "deubiquitinating enzyme" NARROW [PMID:19188440]
synonym: "deubiquitylase" EXACT [GOC:vw, PMID:15657442]
-synonym: "ubiquitin C-terminal hydrolase activity" EXACT [EC:3.4.19.12]
+synonym: "thiol-dependent ubiquitinyl hydrolase activity" EXACT []
+synonym: "ubiquitin C-terminal hydrolase" EXACT [EC:3.4.19.12]
synonym: "ubiquitin hydrolase activity" BROAD [GOC:rl]
synonym: "ubiquitin-specific protease activity" BROAD []
+synonym: "ubiquitinyl hydrolase 1 activity" NARROW []
+synonym: "ubiquitinyl hydrolase activity" BROAD []
synonym: "UBP" NARROW []
synonym: "UCH2" NARROW []
+xref: EC:3.4.19.12
xref: Reactome:R-HSA-1358795 "Deubiquitination of RNF41 by P-USP8"
xref: Reactome:R-HSA-2179291 "UCHL5, USP15 deubiquitinate TGFBR1"
xref: Reactome:R-HSA-3215295 "USP7 deubiquitinates MDM2"
xref: Reactome:R-HSA-3215310 "USP7 deubiquitinates TP53 and counteracts MDM2"
+xref: Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2"
xref: Reactome:R-HSA-4641236 "USP8 deubiquitinates FZD to potentiate WNT signaling"
xref: Reactome:R-HSA-5653770 "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA"
xref: Reactome:R-HSA-5655466 "USP1:WDR48 deubiquitinates monoUb:K164-PCNA"
+xref: Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains"
+xref: Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2"
+xref: Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN"
+xref: Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4"
+xref: Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53"
+xref: Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B"
+xref: Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin"
+xref: Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A"
+xref: Reactome:R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58"
+xref: Reactome:R-HSA-5690196 "USP8 deubiquitinates RNF128"
+xref: Reactome:R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts"
+xref: Reactome:R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1"
+xref: Reactome:R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex"
+xref: Reactome:R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A"
xref: Reactome:R-HSA-5696465 "USP45 deubiquitinates ERCC1"
+xref: Reactome:R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1"
+xref: Reactome:R-HSA-5696564 "USP25 deubiquitinates DDX58"
+xref: Reactome:R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1"
+xref: Reactome:R-HSA-5696605 "USP12, USP26 deubiquitinate AR"
+xref: Reactome:R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG"
+xref: Reactome:R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins"
+xref: Reactome:R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC"
+xref: Reactome:R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB"
+xref: Reactome:R-HSA-5696947 "USP47 deubiquitinates POLB"
+xref: Reactome:R-HSA-5696958 "USP44 deubiquitinates CDC20"
+xref: Reactome:R-HSA-5696960 "USP49 deubiquitinates H2B"
+xref: Reactome:R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2"
+xref: Reactome:R-HSA-5696997 "USP24 deubiquitinates DDB2"
+xref: Reactome:R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2"
+xref: Reactome:R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1"
+xref: Reactome:R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10"
+xref: Reactome:R-HSA-6781814 "USP19 deubiquitinates RNF123"
+xref: Reactome:R-HSA-6781897 "USP11 deubiquitinates NFKBIA"
xref: Reactome:R-HSA-6782069 "UVSSA:USP7 deubiquitinates ERCC6"
+xref: Reactome:R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR"
+xref: Reactome:R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS"
+xref: Reactome:R-HSA-6782820 "USP17 deubiquitinates SUDS3"
+xref: Reactome:R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33"
xref: Reactome:R-HSA-6786171 "FANCD2 deubiquitination by USP1:WDR48"
xref: Reactome:R-HSA-6807118 "USP7 deubiquitinates monoubiquitinated PTEN"
xref: Reactome:R-HSA-6807206 "USP13 and OTUD3 deubiquitinate PTEN"
+xref: Reactome:R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4"
xref: Reactome:R-HSA-8853503 "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin"
xref: Reactome:R-HSA-8853514 "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin"
xref: Reactome:R-HSA-8853515 "OTULIN,USP5 cleaves UBC yielding ubiquitin"
xref: Reactome:R-HSA-8853529 "OTULIN,USP5 cleaves UBB yielding ubiquitin"
+xref: Reactome:R-HSA-8862184 "USP48 cleaves polyubiquitin"
+xref: Reactome:R-HSA-8865182 "OTUD7A hydrolyses K11diUb"
+xref: Reactome:R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6"
+xref: Reactome:R-HSA-8873946 "OTUD3 deubiquitinates PTEN"
xref: Reactome:R-HSA-8875443 "USP8 deubiquitinates LRIG1"
xref: Reactome:R-HSA-8986083 "USP33 deubiquitinates ROBO1"
-is_a: GO:0036459 ! thiol-dependent ubiquitinyl hydrolase activity
+xref: Reactome:R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin"
+xref: Reactome:R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin"
+xref: Reactome:R-HSA-9653514 "USP17L2 deubiquitinates RCE1"
+is_a: GO:0008242 ! omega peptidase activity
+is_a: GO:0101005 ! ubiquitinyl hydrolase activity
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19723 xsd:anyURI
[Term]
id: GO:0004844
@@ -50632,6 +50896,7 @@ synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107]
xref: EC:2.1.1.107
xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN
+xref: RHEA:32459
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
@@ -50685,6 +50950,7 @@ synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
xref: EC:1.17.1.4
xref: MetaCyc:RXN0-901
+xref: RHEA:16669
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
[Term]
@@ -50771,6 +51037,7 @@ synonym: "cyclin dependent kinase inhibitor" RELATED []
synonym: "cyclin dependent protein kinase inhibitor activity" EXACT []
synonym: "cyclin-dependent kinase inhibitor" RELATED []
synonym: "cyclin-dependent protein kinase inhibitor activity" BROAD []
+xref: Reactome:R-HSA-187934 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21"
xref: Reactome:R-HSA-69562 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21"
is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity
@@ -50950,7 +51217,7 @@ alt_id: GO:0008434
alt_id: GO:0038050
alt_id: GO:0038051
alt_id: GO:0038052
-def: "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]
+def: "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH-2018]
comment: GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'nuclear receptor transcription coactivator activity ; GO:0030374'.
synonym: "1,25-(OH)2D3 receptor activity" NARROW [Wikipedia:Calcitriol]
synonym: "9-cis retinoic acid receptor activity" NARROW []
@@ -51136,7 +51403,7 @@ relationship: has_part GO:0019961 ! interferon binding
id: GO:0004905
name: type I interferon receptor activity
namespace: molecular_function
-def: "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834, PR:000025848]
+def: "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "interferon-alpha receptor activity" NARROW []
synonym: "interferon-alpha/beta receptor activity" NARROW []
synonym: "interferon-beta receptor activity" NARROW []
@@ -51698,8 +51965,8 @@ synonym: "GABA-B receptor activity" RELATED [GOC:bf]
synonym: "metabotropic GABA receptor" RELATED [Wikipedia:GABAB_receptor]
xref: Reactome:R-HSA-1013012 "Binding of Gbeta/gamma to GIRK/Kir3 channels"
xref: Reactome:R-HSA-1013013 "Association of GABA B receptor with G protein beta-gamma subunits"
+is_a: GO:0004930 ! G protein-coupled receptor activity
is_a: GO:0016917 ! GABA receptor activity
-is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity
[Term]
id: GO:0004966
@@ -51734,7 +52001,6 @@ name: histamine receptor activity
namespace: molecular_function
def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0008227 ! G protein-coupled amine receptor activity
-is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity
relationship: has_part GO:0051381 ! histamine binding
[Term]
@@ -51818,7 +52084,6 @@ synonym: "mu-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004977 ! melanocortin receptor activity
is_a: GO:0004985 ! opioid receptor activity
is_a: GO:0008188 ! neuropeptide receptor activity
-is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity
relationship: has_part GO:0031626 ! beta-endorphin binding
[Term]
@@ -51906,7 +52171,6 @@ name: octopamine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [GOC:ai]
is_a: GO:0008227 ! G protein-coupled amine receptor activity
-is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity
[Term]
id: GO:0004990
@@ -51943,7 +52207,6 @@ synonym: "G protein coupled serotonin receptor activity" EXACT []
synonym: "G-protein coupled serotonin receptor activity" EXACT []
xref: Wikipedia:5-HT_receptor
is_a: GO:0008227 ! G protein-coupled amine receptor activity
-is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity
is_a: GO:0099589 ! serotonin receptor activity
relationship: has_part GO:0051378 ! serotonin binding
relationship: part_of GO:0098664 ! G protein-coupled serotonin receptor signaling pathway
@@ -52318,7 +52581,7 @@ consider: GO:0042614
id: GO:0005030
name: neurotrophin receptor activity
namespace: molecular_function
-def: "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling, http://www.mercksource.com/]
+def: "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0043121 ! neurotrophin binding
relationship: part_of GO:0038179 ! neurotrophin signaling pathway
@@ -52781,7 +53044,7 @@ xref: Reactome:R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity"
xref: Reactome:R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1"
xref: Reactome:R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1"
xref: Reactome:R-HSA-187746 "RIT/RIN are activated"
-xref: Reactome:R-HSA-2029445 "Activation of CDC42 by unknown mechanism"
+xref: Reactome:R-HSA-2029445 "An unknown GEF exchanges GTP for GDP on CDC42:GDP"
xref: Reactome:R-HSA-2029451 "Activation of RAC1 by VAV"
xref: Reactome:R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO"
xref: Reactome:R-HSA-203977 "SAR1 Activation And Membrane Binding"
@@ -52836,6 +53099,11 @@ xref: Reactome:R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated"
xref: Reactome:R-HSA-8982637 "Opsins binds G alpha-t"
xref: Reactome:R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)"
xref: Reactome:R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs"
+xref: Reactome:R-HSA-9639286 "RRAGC,D exchanges GTP for GDP"
+xref: Reactome:R-HSA-9640167 "RRAGA,B exchanges GDP for GTP"
+xref: Reactome:R-HSA-9660824 "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs"
+xref: Reactome:R-HSA-9666428 "DOCK180 exchanges GTP for GDP on RAC1:GDP"
+xref: Reactome:R-HSA-9666430 "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP"
is_a: GO:0051020 ! GTPase binding
is_a: GO:0098772 ! molecular function regulator
@@ -52857,6 +53125,7 @@ namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
synonym: "RCC1" EXACT []
xref: Reactome:R-HSA-180687 "Conversion of Ran-GDP to Ran-GTP"
+xref: Reactome:R-HSA-9624845 "RCC1 stimulates GDP to GTP exchange on RAN"
xref: Wikipedia:RCC1
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity
is_a: GO:0008536 ! Ran GTPase binding
@@ -52877,7 +53146,7 @@ xref: Reactome:R-HSA-1306972 "RAS guanyl nucleotide exchange mediated by SOS1 bo
xref: Reactome:R-HSA-1433471 "Activation of RAS by p-KIT bound SOS1"
xref: Reactome:R-HSA-177938 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)"
xref: Reactome:R-HSA-177945 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)"
-xref: Reactome:R-HSA-186834 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)"
+xref: Reactome:R-HSA-186834 "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)"
xref: Reactome:R-HSA-210977 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)"
xref: Reactome:R-HSA-2179407 "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)"
xref: Reactome:R-HSA-2424477 "SOS mediated nucleotide exchange of RAS (SHC)"
@@ -52904,6 +53173,17 @@ xref: Reactome:R-HSA-8853307 "FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucle
xref: Reactome:R-HSA-9026891 "NTRK2 activates RAS signaling through SHC1"
xref: Reactome:R-HSA-9029158 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS"
xref: Reactome:R-HSA-9032067 "NTRK2 activates RAS signaling through FRS2"
+xref: Reactome:R-HSA-9607304 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)"
+xref: Reactome:R-HSA-9634418 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1"
+xref: Reactome:R-HSA-9664991 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants"
+xref: Reactome:R-HSA-9665009 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR"
+xref: Reactome:R-HSA-9665404 "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1"
+xref: Reactome:R-HSA-9665408 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2"
+xref: Reactome:R-HSA-9665700 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants"
+xref: Reactome:R-HSA-9665707 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR"
+xref: Reactome:R-HSA-9670436 "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS"
+xref: Reactome:R-HSA-9672163 "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers"
+xref: Reactome:R-HSA-9672170 "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors"
is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity
is_a: GO:0017016 ! Ras GTPase binding
@@ -53020,6 +53300,7 @@ xref: Reactome:R-HSA-428522 "Inactivation of RAC1"
xref: Reactome:R-HSA-428533 "Inactivation of CDC42"
xref: Reactome:R-HSA-5638007 "RP2 activates the GTPase activity of ARL3"
xref: Reactome:R-HSA-8985594 "MYO9B inactivates RHOA"
+xref: Reactome:R-HSA-9624893 "RAN stimulates fusion of nuclear envelope (NE) membranes"
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0030695 ! GTPase regulator activity
relationship: part_of GO:0043547 ! positive regulation of GTPase activity
@@ -53107,7 +53388,7 @@ id: GO:0005109
name: frizzled binding
namespace: molecular_function
alt_id: GO:0005110
-def: "Interacting selectively and non-covalently with a frizzled (fz) receptor." [GOC:ceb, PR:000001315]
+def: "Interacting selectively and non-covalently with a frizzled (fz) receptor." [GOC:ceb]
subset: goslim_chembl
synonym: "frizzled ligand" NARROW []
synonym: "frizzled-2 binding" NARROW []
@@ -53641,7 +53922,6 @@ synonym: "transforming growth factor beta ligand binding to type I receptor" REL
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "transforming growth factor beta receptor anchoring activity" RELATED []
synonym: "transforming growth factor beta receptor ligand" NARROW []
-xref: Reactome:R-HSA-170861 "Dimeric TGF-beta-1 binds to the receptor"
is_a: GO:0005126 ! cytokine receptor binding
[Term]
@@ -54267,6 +54547,7 @@ def: "Enables the transmembrane transfer of chloride by a channel that opens in
xref: Reactome:R-HSA-2684901 "ANOs transport cytosolic Cl- to extracellular region"
xref: Reactome:R-HSA-2744242 "TTYH2/3 transport cytosolic Cl- to extracellular region"
xref: Reactome:R-HSA-2744361 "BESTs transport cytosolic Cl- to extracellular region"
+xref: Reactome:R-HSA-9659568 "ANO1 transports cytosolic Cl- to extracellular region"
is_a: GO:0022839 ! ion gated channel activity
is_a: GO:0061778 ! intracellular chloride channel activity
@@ -54439,7 +54720,7 @@ id: GO:0005250
name: A-type (transient outward) potassium channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340]
-xref: Reactome:R-HSA-5577234 "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extrqcellular region"
+xref: Reactome:R-HSA-5577234 "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region"
is_a: GO:0015271 ! outward rectifier potassium channel activity
[Term]
@@ -54466,6 +54747,7 @@ def: "Enables the energy-independent passage of anions across a lipid bilayer do
synonym: "non-selective anion channel activity" NARROW []
xref: Reactome:R-HSA-432034 "Aquaporin-6 passively transports anions into vesicles"
xref: Reactome:R-HSA-432036 "Aquaporin-6 passively transports anions out of vesicles"
+xref: RHEA:34923
is_a: GO:0005216 ! ion channel activity
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
disjoint_from: GO:0005261 ! cation channel activity
@@ -54478,7 +54760,7 @@ def: "Enables the facilitated diffusion of a chloride (by an energy-independent
xref: Reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region"
xref: Reactome:R-HSA-427570 "Group 3 - Selective Cl- transport"
xref: Reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol"
-xref: Reactome:R-HSA-975449 "GABRR pentamer:GABA transports extracellular Cl- to cytosol"
+xref: Reactome:R-HSA-975449 "GABRR pentamers:GABA transports extracellular Cl- to cytosol"
is_a: GO:0005253 ! anion channel activity
is_a: GO:0015108 ! chloride transmembrane transporter activity
@@ -54527,7 +54809,6 @@ xref: Reactome:R-HSA-139854 "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ fro
xref: Reactome:R-HSA-139855 "P2X1-mediated entry of Ca++ from plasma"
xref: Reactome:R-HSA-210420 "Ca2+ influx through voltage gated Ca2+ channels"
xref: Reactome:R-HSA-3295579 "TRPs transport extracellular Ca2+ to cytosol"
-xref: Reactome:R-HSA-5263618 "CACFD1 dimer transports Ca2+ from extracellular region to cytosol"
xref: Reactome:R-HSA-8949145 "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space"
xref: Reactome:R-HSA-8949178 "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix"
is_a: GO:0005261 ! cation channel activity
@@ -54539,7 +54820,7 @@ name: potassium channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
xref: Reactome:R-HSA-1296024 "Activation of ATP sensitive Potassium channels in neuroendocrine cells"
-xref: Reactome:R-HSA-1296035 "Activation of Ca2+ activated Potassium channels with Intermeidtance conductance"
+xref: Reactome:R-HSA-1296035 "Activation of Ca2+ activated Potassium channels with Intermediate conductance"
xref: Reactome:R-HSA-1296037 "Activation of Ca2+ activated Potassium channels with large conductance"
xref: Reactome:R-HSA-1296039 "Activation of Ca2+ activated Potassium channels with small conductance"
xref: Reactome:R-HSA-1296348 "Activation of TWIK-related K+ channel (TREK)"
@@ -54558,7 +54839,7 @@ id: GO:0005272
name: sodium channel activity
namespace: molecular_function
def: "Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
-xref: Reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports cytosolic Na+ to extracellular region"
+xref: Reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol"
xref: Reactome:R-HSA-3295580 "TRPM4,5 transport extracellular Na+ to cytosol"
is_a: GO:0005261 ! cation channel activity
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
@@ -54603,7 +54884,7 @@ id: GO:0005277
name: acetylcholine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
-xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicle"
+xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles"
is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:1901375 ! acetate ester transmembrane transporter activity
@@ -54811,8 +55092,8 @@ name: choline:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5]
synonym: "sodium/choline symporter activity" EXACT []
-is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0015220 ! choline transmembrane transporter activity
+is_a: GO:0015370 ! solute:sodium symporter activity
[Term]
id: GO:0005308
@@ -54820,7 +55101,6 @@ name: creatine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:0015881 ! creatine transmembrane transport
@@ -54875,7 +55155,6 @@ xref: Reactome:R-HSA-210444 "L-Glutamate loading of synaptic vesicle"
xref: Reactome:R-HSA-428052 "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+"
xref: Reactome:R-HSA-5624256 "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+"
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
-is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0015813 ! L-glutamate transmembrane transport
@@ -54891,7 +55170,6 @@ xref: Reactome:R-HSA-428015 "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na
xref: Reactome:R-HSA-5625015 "Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5625029 "SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol"
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
-is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0015501 ! glutamate:sodium symporter activity
[Term]
@@ -55060,7 +55338,6 @@ synonym: "GABA:sodium symporter activity" EXACT []
synonym: "sodium/chloride-dependent GABA transporter activity" BROAD []
xref: Reactome:R-HSA-444007 "GAT1-3 mediate Na+/Cl- dependent GABA transport"
is_a: GO:0005283 ! amino acid:sodium symporter activity
-is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity
is_a: GO:0140161 ! monocarboxylate:sodium symporter activity
@@ -55095,8 +55372,9 @@ synonym: "serotonin transmembrane transporter activity" EXACT []
synonym: "serotonin:sodium:chloride symporter activity" EXACT []
synonym: "sodium/serotonin symporter activity" EXACT []
xref: Reactome:R-HSA-444008 "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol"
-is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
+xref: RHEA:51196
is_a: GO:0008504 ! monoamine transmembrane transporter activity
+is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015378 ! sodium:chloride symporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:0051610 ! serotonin uptake
@@ -55116,6 +55394,7 @@ xref: Reactome:R-HSA-727740 "Equilibrative transport (import) of adenosine and b
xref: Reactome:R-HSA-727749 "SLC29A3 transports nucleosides from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-727767 "SLC29A3 transports nucleosides from cytosol to lysosomal lumen"
xref: Reactome:R-HSA-727768 "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4"
+xref: RHEA:27318
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity
relationship: part_of GO:1901642 ! nucleoside transmembrane transport
@@ -55387,6 +55666,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to
synonym: "hydrogen/myo-inositol transporter activity" BROAD []
synonym: "myo-inositol:hydrogen symporter activity" EXACT []
xref: Reactome:R-HSA-429101 "HMIT co-transports myo-inositol with a proton"
+xref: RHEA:60364
is_a: GO:0005365 ! myo-inositol transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
@@ -55510,6 +55790,7 @@ xref: Reactome:R-HSA-5623558 "Defective SLC11A2 does not cotransport Fe2+, H+ fr
xref: Reactome:R-HSA-5655733 "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region"
xref: Reactome:R-HSA-904830 "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region"
xref: Reactome:R-HSA-917936 "MCOLN1 transports Fe2+ from endosome lumen to cytosol"
+xref: RHEA:29579
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
relationship: part_of GO:0034755 ! iron ion transmembrane transport
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17162 xsd:anyURI
@@ -55520,6 +55801,7 @@ name: manganese ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf]
xref: Reactome:R-HSA-8959798 "SLC30A10 transports Mn2+ from cytosol to extracellular region"
+xref: RHEA:28699
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity
relationship: part_of GO:0071421 ! manganese ion transmembrane transport
@@ -55595,7 +55877,7 @@ synonym: "sodium/potassium-transporting ATPase activity" EXACT []
synonym: "sodium:potassium exchanging ATPase activity" EXACT []
xref: EC:7.2.2.13
xref: MetaCyc:3.6.3.9-RXN
-xref: Reactome:R-HSA-936897 "ATP1A:ATP1B:FXYD exchanges Na+ for K+"
+xref: Reactome:R-HSA-936897 "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+"
xref: RHEA:18353
is_a: GO:0008554 ! sodium transmembrane transporter activity, phosphorylative mechanism
is_a: GO:0008556 ! potassium transmembrane transporter activity, phosphorylative mechanism
@@ -55607,9 +55889,6 @@ name: obsolete eye pigment precursor transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1]
comment: This term has been obsoleted because eye pigment precursors are nucleotides and amino acids, and there are terms to annotate these functions.
-xref: Reactome:R-HSA-1467466 "ABCA4 mediates atRAL transport"
-xref: Reactome:R-HSA-2466749 "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol"
-xref: Reactome:R-HSA-2466802 "Defective ABCA4 does not transport NRPE from disc membranes"
is_obsolete: true
[Term]
@@ -55720,6 +55999,7 @@ synonym: "sodium:calcium exchange" RELATED []
xref: Reactome:R-HSA-425661 "SLC8A1,2,3 exchange 3Na+ for Ca2+"
xref: Reactome:R-HSA-8949688 "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)"
xref: Reactome:R-HSA-8949703 "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)"
+xref: RHEA:29255
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015368 ! calcium:cation antiporter activity
@@ -55732,6 +56012,15 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to
synonym: "sodium-dependent phosphate transmembrane transporter activity" RELATED []
synonym: "sodium/phosphate symporter activity" EXACT []
xref: Reactome:R-HSA-2872498 "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol"
+xref: Reactome:R-HSA-427605 "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol"
+xref: Reactome:R-HSA-427645 "SLC34A3 cotransports Pi, 2Na+"
+xref: Reactome:R-HSA-427656 "SLC34A1,2 cotransports HPO4(2-), 3Na+ from extracellular region to cytosol"
+xref: Reactome:R-HSA-428609 "Type I Na+-coupled phosphate co-transport"
+xref: Reactome:R-HSA-5625123 "Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol"
+xref: Reactome:R-HSA-5651685 "Defective SLC34A1 does not cotransport Pi, 3Na+"
+xref: Reactome:R-HSA-5651697 "Defective SLC34A2 does not cotransport Pi, 3Na+"
+xref: Reactome:R-HSA-5651971 "Defective SLC34A3 does not cotransport Pi, 2Na+"
+xref: Reactome:R-HSA-5687585 "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol"
is_a: GO:0015370 ! solute:sodium symporter activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18577 xsd:anyURI
@@ -56191,8 +56480,6 @@ subset: goslim_pir
subset: goslim_plant
synonym: "glycoprotein binding" NARROW []
synonym: "protein amino acid binding" EXACT []
-xref: Reactome:R-HSA-170835 "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3"
-xref: Reactome:R-HSA-170846 "TGFBR2 recruits TGFBR1"
is_a: GO:0005488 ! binding
[Term]
@@ -56264,7 +56551,6 @@ name: ATP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]
xref: Reactome:R-HSA-265682 "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel"
-is_a: GO:0008144 ! drug binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0035639 ! purine ribonucleoside triphosphate binding
@@ -56294,6 +56580,7 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl]
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED []
is_a: GO:0005527 ! macrolide binding
+is_a: GO:0033218 ! amide binding
[Term]
id: GO:0005530
@@ -56401,7 +56688,6 @@ def: "Interacting selectively and non-covalently with folic acid, pteroylglutami
synonym: "folate binding" EXACT []
synonym: "vitamin B9 binding" EXACT []
synonym: "vitamin M binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0019842 ! vitamin binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0033218 ! amide binding
@@ -57120,16 +57406,14 @@ is_a: GO:0005575 ! cellular_component
[Term]
id: GO:0005623
-name: cell
+name: obsolete cell
namespace: cellular_component
-def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators]
-subset: goslim_chembl
-subset: goslim_generic
-subset: goslim_plant
+def: "OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators]
+comment: This term was obsoleted because it was redundant with the root class of the cell ontology, CL:0000000.
xref: NIF_Subcellular:sao1813327414
xref: Wikipedia:Cell_(biology)
-is_a: GO:0005575 ! cellular_component
property_value: IAO:0000589 "cell and encapsulating structures" xsd:string
+is_obsolete: true
[Term]
id: GO:0005624
@@ -61175,7 +61459,6 @@ synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT []
synonym: "chitin metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process
[Term]
@@ -61205,7 +61488,6 @@ synonym: "chitin catabolism" EXACT []
synonym: "chitin degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0006030 ! chitin metabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901072 ! glucosamine-containing compound catabolic process
[Term]
@@ -61447,8 +61729,9 @@ synonym: "N-acetylneuraminate metabolism" EXACT []
synonym: "sialic acid metabolic process" BROAD []
synonym: "sialic acid metabolism" BROAD []
is_a: GO:0006040 ! amino sugar metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
+is_a: GO:0043603 ! cellular amide metabolic process
+is_a: GO:1901564 ! organonitrogen compound metabolic process
[Term]
id: GO:0006055
@@ -61589,7 +61872,6 @@ name: ethanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732]
synonym: "ethanol metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
[Term]
@@ -61601,9 +61883,7 @@ synonym: "ethanol breakdown" EXACT []
synonym: "ethanol catabolism" EXACT []
synonym: "ethanol degradation" EXACT []
is_a: GO:0006067 ! ethanol metabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0006069
@@ -61777,7 +62057,6 @@ name: acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators]
synonym: "acetate metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
[Term]
@@ -61975,7 +62254,6 @@ name: citrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]
synonym: "citrate metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
[Term]
@@ -62015,7 +62293,6 @@ name: succinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732]
synonym: "succinate metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
[Term]
@@ -62127,7 +62404,6 @@ synonym: "ethanol biosynthesis" EXACT []
synonym: "ethanol formation" EXACT []
synonym: "ethanol synthesis" EXACT []
is_a: GO:0006067 ! ethanol metabolic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
[Term]
@@ -62194,7 +62470,7 @@ relationship: has_part GO:0015986 ! ATP synthesis coupled proton transport
id: GO:0006120
name: mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
-def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]
+def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]
synonym: "complex I (NADH to ubiquinone)" RELATED []
synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT []
is_a: GO:0022904 ! respiratory electron transport chain
@@ -62557,7 +62833,6 @@ synonym: "adenosine breakdown" EXACT []
synonym: "adenosine catabolism" EXACT []
synonym: "adenosine degradation" EXACT []
synonym: "adenosine phosphorolysis" RELATED []
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046085 ! adenosine metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process
@@ -63005,7 +63280,6 @@ synonym: "AMP catabolism" EXACT []
synonym: "AMP degradation" EXACT []
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046033 ! AMP metabolic process
[Term]
@@ -63200,7 +63474,6 @@ synonym: "uracil catabolism" EXACT []
synonym: "uracil degradation" EXACT []
is_a: GO:0006208 ! pyrimidine nucleobase catabolic process
is_a: GO:0019860 ! uracil metabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0006213
@@ -66495,8 +66768,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]
synonym: "glycine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process
-is_a: GO:0017144 ! drug metabolic process
-is_a: GO:0042133 ! neurotransmitter metabolic process
[Term]
id: GO:0006545
@@ -66510,7 +66781,6 @@ synonym: "glycine synthesis" EXACT []
xref: MetaCyc:GLYCINE-SYN2-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process
-is_a: GO:0042136 ! neurotransmitter biosynthetic process
[Term]
id: GO:0006546
@@ -66522,8 +66792,6 @@ synonym: "glycine catabolism" EXACT []
synonym: "glycine degradation" EXACT []
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process
-is_a: GO:0042135 ! neurotransmitter catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0006547
@@ -66638,7 +66906,6 @@ synonym: "S-adenosylmethionine formation" EXACT []
synonym: "S-adenosylmethionine synthesis" EXACT []
synonym: "SAM biosynthetic process" EXACT []
xref: MetaCyc:SAM-PWY
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046500 ! S-adenosylmethionine metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
@@ -66666,7 +66933,6 @@ synonym: "L-phenylalanine metabolism" EXACT []
synonym: "phenylalanine metabolic process" BROAD []
synonym: "phenylalanine metabolism" BROAD []
is_a: GO:0009072 ! aromatic amino acid family metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
[Term]
@@ -66681,7 +66947,6 @@ synonym: "phenylalanine catabolic process" BROAD []
synonym: "phenylalanine catabolism" BROAD []
is_a: GO:0006558 ! L-phenylalanine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1902222 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
[Term]
@@ -66945,8 +67210,6 @@ synonym: "acetylcholine catabolism" EXACT []
synonym: "acetylcholine degradation" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:0042135 ! neurotransmitter catabolic process
-is_a: GO:0042447 ! hormone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901575 ! organic substance catabolic process
[Term]
@@ -67136,7 +67399,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023]
synonym: "creatine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
[Term]
@@ -67571,7 +67833,6 @@ name: acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]
synonym: "acyl-CoA metabolism" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
@@ -67721,7 +67982,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin." [ISBN:0198506732]
synonym: "1,2-diacyl-sn-glycero-3-phosphocholine metabolism" EXACT [GOC:mah]
synonym: "lecithin metabolic process" BROAD []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046470 ! phosphatidylcholine metabolic process
[Term]
@@ -67842,6 +68102,7 @@ synonym: "platelet activating factor anabolism" EXACT []
synonym: "platelet activating factor biosynthesis" EXACT []
synonym: "platelet activating factor formation" EXACT []
synonym: "platelet activating factor synthesis" EXACT []
+is_a: GO:0008611 ! ether lipid biosynthetic process
is_a: GO:0046469 ! platelet activating factor metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
@@ -68307,8 +68568,8 @@ synonym: "glucocorticoid anabolism" EXACT []
synonym: "glucocorticoid biosynthesis" EXACT []
synonym: "glucocorticoid formation" EXACT []
synonym: "glucocorticoid synthesis" EXACT []
+is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008211 ! glucocorticoid metabolic process
-is_a: GO:0120178 ! steroid hormone biosynthetic process
[Term]
id: GO:0006705
@@ -68370,7 +68631,6 @@ synonym: "progesterone degradation" EXACT []
is_a: GO:0008208 ! C21-steroid hormone catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042448 ! progesterone metabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0006710
@@ -68420,7 +68680,6 @@ synonym: "glucocorticoid catabolism" EXACT []
synonym: "glucocorticoid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008211 ! glucocorticoid metabolic process
-is_a: GO:0042447 ! hormone catabolic process
[Term]
id: GO:0006714
@@ -68442,7 +68701,6 @@ synonym: "farnesol synthesis" EXACT []
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0016487 ! farnesol metabolic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
[Term]
@@ -68596,7 +68854,6 @@ synonym: "tetrahydrobiopterin anabolism" EXACT []
synonym: "tetrahydrobiopterin biosynthesis" EXACT []
synonym: "tetrahydrobiopterin formation" EXACT []
synonym: "tetrahydrobiopterin synthesis" EXACT []
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0046146 ! tetrahydrobiopterin metabolic process
@@ -68626,29 +68883,30 @@ def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and pros
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true
-consider: GO:0006732
consider: GO:0051189
[Term]
id: GO:0006732
-name: coenzyme metabolic process
+name: obsolete coenzyme metabolic process
namespace: biological_process
alt_id: GO:0006752
-def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
+def: "OBSOLETE. The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "coenzyme and prosthetic group metabolic process" BROAD []
synonym: "coenzyme and prosthetic group metabolism" BROAD []
synonym: "coenzyme metabolism" EXACT []
synonym: "group transfer coenzyme metabolic process" NARROW []
synonym: "group transfer coenzyme metabolism" NARROW []
-is_a: GO:0051186 ! cofactor metabolic process
+is_obsolete: true
[Term]
id: GO:0006733
-name: oxidoreduction coenzyme metabolic process
+name: obsolete oxidoreduction coenzyme metabolic process
namespace: biological_process
-def: "The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah]
+def: "OBSOLETE. The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "oxidoreduction coenzyme metabolism" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
+is_obsolete: true
[Term]
id: GO:0006734
@@ -68789,7 +69047,6 @@ def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble
synonym: "coenzyme Q metabolic process" EXACT []
synonym: "coenzyme Q metabolism" EXACT []
synonym: "ubiquinone metabolism" EXACT []
-is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process
is_a: GO:1901661 ! quinone metabolic process
[Term]
@@ -68797,6 +69054,7 @@ id: GO:0006744
name: ubiquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
+subset: goslim_pombe
synonym: "coenzyme Q biosynthesis" EXACT []
synonym: "coenzyme Q biosynthetic process" EXACT []
synonym: "coenzyme Q10 biosynthesis" NARROW []
@@ -68822,7 +69080,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide." [GOC:ai]
synonym: "FADH2 metabolism" EXACT []
synonym: "reduced flavin adenine dinucleotide metabolic process" EXACT [GOC:mah]
-is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process
[Term]
@@ -68863,7 +69120,6 @@ synonym: "oxidized glutathione reduction" NARROW []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
[Term]
id: GO:0006750
@@ -68879,7 +69135,6 @@ is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
[Term]
id: GO:0006751
@@ -68893,7 +69148,6 @@ is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
-is_a: GO:0051187 ! cofactor catabolic process
[Term]
id: GO:0006753
@@ -68919,7 +69173,6 @@ synonym: "ATP regeneration" NARROW []
synonym: "ATP synthesis" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046034 ! ATP metabolic process
[Term]
@@ -68968,7 +69221,6 @@ synonym: "vitamin B9 and derivative metabolism" EXACT []
synonym: "vitamin M and derivative metabolic process" EXACT []
synonym: "vitamin M and derivative metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
@@ -69031,10 +69283,8 @@ synonym: "vitamin B7 metabolism" EXACT []
synonym: "vitamin H metabolic process" EXACT []
synonym: "vitamin H metabolism" EXACT []
xref: Wikipedia:Biotin
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
@@ -69054,9 +69304,7 @@ synonym: "vitamin B3 metabolism" BROAD []
xref: MetaCyc:PWY-5083
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
[Term]
@@ -69071,7 +69319,6 @@ synonym: "vitamin G metabolic process" EXACT []
synonym: "vitamin G metabolism" EXACT []
xref: Wikipedia:Riboflavin
is_a: GO:0006767 ! water-soluble vitamin metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process
[Term]
@@ -69128,7 +69375,6 @@ synonym: "Moco biosynthesis" EXACT []
synonym: "Moco biosynthetic process" EXACT []
synonym: "molybdenum cofactor biosynthetic process" RELATED []
xref: MetaCyc:PWY-6823
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
@@ -69146,7 +69392,6 @@ def: "The chemical reactions and pathways involving any member of a large group
synonym: "porphyrin metabolic process" RELATED []
synonym: "porphyrin metabolism" RELATED []
is_a: GO:0033013 ! tetrapyrrole metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
[Term]
id: GO:0006779
@@ -69160,7 +69405,6 @@ synonym: "porphyrin formation" RELATED []
synonym: "porphyrin synthesis" RELATED []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
[Term]
id: GO:0006780
@@ -69273,7 +69517,6 @@ synonym: "porphyrin catabolism" RELATED []
synonym: "porphyrin degradation" RELATED []
is_a: GO:0006778 ! porphyrin-containing compound metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process
-is_a: GO:0051187 ! cofactor catabolic process
[Term]
id: GO:0006788
@@ -69513,7 +69756,6 @@ synonym: "nitric oxide anabolism" EXACT []
synonym: "nitric oxide biosynthesis" EXACT []
synonym: "nitric oxide formation" EXACT []
synonym: "nitric oxide synthesis" EXACT []
-is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046209 ! nitric oxide metabolic process
is_a: GO:1903409 ! reactive oxygen species biosynthetic process
@@ -69748,8 +69990,7 @@ id: GO:0006837
name: serotonin transport
namespace: biological_process
def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
-is_a: GO:0006812 ! cation transport
-is_a: GO:0006836 ! neurotransmitter transport
+is_a: GO:0015695 ! organic cation transport
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport
@@ -69814,7 +70055,6 @@ name: acyl carnitine transport
namespace: biological_process
def: "The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai]
is_a: GO:0015697 ! quaternary ammonium group transport
-is_a: GO:0051181 ! cofactor transport
[Term]
id: GO:0006845
@@ -70605,7 +70845,7 @@ relationship: part_of GO:0043029 ! T cell homeostasis
id: GO:0006925
name: inflammatory cell apoptotic process
namespace: biological_process
-def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis, http://www.mercksource.com/]
+def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis]
synonym: "apoptosis of inflammatory cells" EXACT []
synonym: "inflammatory cell apoptosis" NARROW []
synonym: "inflammatory cell programmed cell death by apoptosis" EXACT []
@@ -72210,6 +72450,7 @@ def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a
synonym: "Dma1-dependent checkpoint" NARROW []
synonym: "Mad2-dependent checkpoint" NARROW []
synonym: "mitotic cell cycle spindle assembly checkpoint" EXACT []
+synonym: "mitotic checkpoint" EXACT []
synonym: "SAC-independent checkpoint" NARROW []
is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition
is_a: GO:0071173 ! spindle assembly checkpoint
@@ -72544,12 +72785,13 @@ is_a: GO:0098764 ! meiosis I cell cycle phase
[Term]
id: GO:0007129
-name: synapsis
+name: homologous chromosome pairing at meiosis
namespace: biological_process
-def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617]
+def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]
synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
-synonym: "chromosomal synapsis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
+synonym: "chromosomal synapsis" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "homologous chromosome pairing at meiosis" EXACT []
+synonym: "synapsis" NARROW []
xref: Wikipedia:Synapsis
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
relationship: part_of GO:0045143 ! homologous chromosome segregation
@@ -72563,7 +72805,7 @@ synonym: "synaptonemal complex formation" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
is_a: GO:0070193 ! synaptonemal complex organization
-relationship: part_of GO:0007129 ! synapsis
+relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis
[Term]
id: GO:0007131
@@ -72975,7 +73217,7 @@ is_a: GO:0034622 ! cellular protein-containing complex assembly
id: GO:0007173
name: epidermal growth factor receptor signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933]
+def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]
synonym: "EGF receptor signaling pathway" EXACT []
synonym: "EGF receptor signalling pathway" EXACT []
synonym: "EGFR signaling pathway" EXACT []
@@ -77283,7 +77525,7 @@ is_a: GO:0007632 ! visual behavior
id: GO:0007634
name: optokinetic behavior
namespace: biological_process
-def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr, http://www.mercksource.com]
+def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr]
synonym: "optokinetic behaviour" EXACT []
is_a: GO:0007632 ! visual behavior
@@ -77460,6 +77702,7 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
synonym: "microtubule severing activity" RELATED []
synonym: "microtubule/chromatin interaction" RELATED []
+xref: Reactome:R-HSA-9614343 "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs"
is_a: GO:0015631 ! tubulin binding
[Term]
@@ -77574,8 +77817,9 @@ def: "Enables the transfer of monocarboxylic acids from one side of a membrane t
synonym: "monocarboxylate carrier" NARROW []
synonym: "prostaglandin/thromboxane transporter activity" NARROW []
xref: Reactome:R-HSA-429749 "SLC5A8 transports monocarboxylates from extracellular region to cytosol"
-xref: Reactome:R-HSA-433698 "SLC16A1,3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol"
+xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol"
+xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
relationship: part_of GO:0015718 ! monocarboxylic acid transport
@@ -77840,7 +78084,6 @@ name: chitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
subset: goslim_drosophila
-is_a: GO:0008144 ! drug binding
is_a: GO:0097367 ! carbohydrate derivative binding
[Term]
@@ -78027,6 +78270,7 @@ xref: EC:2.3.1.5
xref: Reactome:R-HSA-2468039 "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2"
xref: Reactome:R-HSA-2473152 "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2"
xref: Reactome:R-HSA-6790987 "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842"
+xref: Reactome:R-HSA-9636560 "Eis acetylates DUSP16"
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016410 ! N-acyltransferase activity
@@ -78152,10 +78396,10 @@ is_a: GO:0005515 ! protein binding
id: GO:0008093
name: cytoskeletal anchor activity
namespace: molecular_function
-def: "The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238]
+def: "The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238]
synonym: "cytoskeletal adaptor activity" EXACT []
-is_a: GO:0008092 ! cytoskeletal protein binding
is_a: GO:0030674 ! protein-macromolecule adaptor activity
+relationship: has_part GO:0008092 ! cytoskeletal protein binding
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17668 xsd:anyURI
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19119 xsd:anyURI
@@ -78237,6 +78481,7 @@ synonym: "aldehyde reductase (NADPH2) activity" EXACT []
synonym: "NADP-aldehyde reductase activity" EXACT []
xref: EC:1.1.1.2
xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN
+xref: RHEA:15937
is_a: GO:0004033 ! aldo-keto reductase (NADP) activity
[Term]
@@ -78385,6 +78630,7 @@ xref: MetaCyc:RXN-8668
xref: MetaCyc:RXN-8669
xref: Reactome:R-HSA-1222363 "MsrA/B reduces peptide-methionine S/R-sulfoxides"
xref: Reactome:R-HSA-5676940 "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine"
+xref: RHEA:14217
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
[Term]
@@ -78587,8 +78833,6 @@ synonym: "elaszym" RELATED [EC:3.4.21.36]
synonym: "pancreatic elastase I activity" EXACT []
synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36]
synonym: "serine elastase" BROAD [EC:3.4.21.36]
-xref: EC:3.4.21.36
-xref: MetaCyc:3.4.21.36-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -78605,6 +78849,7 @@ synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6]
synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6]
xref: EC:3.1.1.6
xref: MetaCyc:ACETYLESTERASE-RXN
+xref: RHEA:12957
xref: UM-BBD_reactionID:r0170
is_a: GO:0034338 ! short-chain carboxylesterase activity
@@ -78634,8 +78879,6 @@ synonym: "actinidain activity" EXACT []
synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14]
synonym: "actinidin activity" EXACT [EC:3.4.22.14]
synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14]
-xref: EC:3.4.22.14
-xref: MetaCyc:3.4.22.14-RXN
is_obsolete: true
replaced_by: GO:0004197
@@ -78649,8 +78892,6 @@ synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34]
synonym: "MMP-8" EXACT []
synonym: "neutrophil collagenase activity" EXACT []
synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34]
-xref: EC:3.4.24.34
-xref: MetaCyc:3.4.24.34-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -78671,8 +78912,8 @@ xref: Reactome:R-HSA-141186 "MAOA:FAD oxidatively deaminates of 5HT"
xref: Reactome:R-HSA-141200 "MAOB:FAD oxidatively deaminates of PEA"
xref: Reactome:R-HSA-141202 "MAOB:FAD oxidatively deaminates TYR"
xref: Reactome:R-HSA-374909 "Metabolism of Noradrenaline"
-xref: Reactome:R-HSA-379382 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC)"
-xref: Reactome:R-HSA-379395 "Oxidation of 3-Methoxytyramine to homovanillic acid"
+xref: Reactome:R-HSA-379382 "MAOA:FAD deaminates DA to DOPAC"
+xref: Reactome:R-HSA-379395 "MAOA:FAD deaminates 3MT to HVA"
xref: Reactome:R-HSA-5603108 "Defective MAOA does not oxidatively deaminate 5HT"
xref: Reactome:R-HSA-5696146 "AOC2 deaminates TYR"
xref: Reactome:R-HSA-5696183 "AOC3 deaminates BZAM"
@@ -78685,7 +78926,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71]
comment: This term was made obsolete because it represents a gene product.
synonym: "pancreatic elastase activity" EXACT []
-xref: EC:3.4.21
is_obsolete: true
replaced_by: GO:0004252
@@ -78696,7 +78936,6 @@ namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagenase activity" EXACT []
-xref: EC:3.4.24
is_obsolete: true
replaced_by: GO:0004222
@@ -78774,6 +79013,7 @@ comment: Note that this term applies only to free amino acids. Consider 'protein
synonym: "dual-specificity protein phosphatase" BROAD []
xref: Reactome:R-HSA-5675373 "Nuclear DUSPs dephosphorylate MAPKs"
xref: Reactome:R-HSA-5675376 "Cytosolic DUSPs dephosphorylate MAPKs"
+xref: Reactome:R-HSA-9652816 "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs"
is_a: GO:0004721 ! phosphoprotein phosphatase activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12183 xsd:anyURI
@@ -78857,6 +79097,7 @@ xref: Reactome:R-HSA-176588 "lithocholate + PAPS => lithocholate sulfate + PAP"
xref: Reactome:R-HSA-176604 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP"
xref: Reactome:R-HSA-176669 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP"
xref: Reactome:R-HSA-2022061 "Dermatan sulfate can be further sulfated on position 2 of iduronate"
+xref: RHEA:51064
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups
[Term]
@@ -79106,8 +79347,9 @@ subset: goslim_generic
subset: goslim_yeast
synonym: "methylase" BROAD []
xref: EC:2.1.1
-xref: Reactome:R-HSA-379387 "methylation of Dopamine to form 3-Methoxytyramine"
-xref: Reactome:R-HSA-379464 "Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid"
+xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3"
+xref: Reactome:R-HSA-379387 "COMT transfers Met to DA to form 3MT"
+xref: Reactome:R-HSA-379464 "COMT transfers Met to DOPAC to form HVA"
xref: Reactome:R-HSA-6800149 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII"
xref: Reactome:R-HSA-71286 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine"
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups
@@ -79199,6 +79441,7 @@ synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33]
xref: EC:2.1.1.33
xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-6782286 "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46"
+xref: RHEA:42708
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity
relationship: part_of GO:0106004 ! tRNA (guanine-N7)-methylation
@@ -79525,7 +79768,6 @@ synonym: "glucocorticoid metabolism" EXACT []
synonym: "glucocorticosteroid metabolic process" EXACT []
synonym: "glucocorticosteroid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
-is_a: GO:0042445 ! hormone metabolic process
[Term]
id: GO:0008212
@@ -79560,7 +79802,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:curators]
synonym: "spermine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process
-is_a: GO:0017144 ! drug metabolic process
[Term]
id: GO:0008216
@@ -79657,7 +79898,6 @@ name: tyramine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [GOC:curators]
is_a: GO:0008227 ! G protein-coupled amine receptor activity
-is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity
[Term]
id: GO:0008227
@@ -79716,6 +79956,8 @@ is_a: GO:0008230 ! ecdysone receptor holocomplex
id: GO:0008233
name: peptidase activity
namespace: molecular_function
+alt_id: GO:0070010
+alt_id: GO:0070011
def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
subset: goslim_aspergillus
subset: goslim_candida
@@ -79726,19 +79968,25 @@ subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
synonym: "hydrolase, acting on peptide bonds" EXACT []
+synonym: "peptidase activity, acting on D-amino acid peptides" NARROW []
+synonym: "peptidase activity, acting on L-amino acid peptides" NARROW []
synonym: "peptide hydrolase activity" EXACT []
synonym: "protease activity" EXACT []
synonym: "proteinase activity" NARROW []
xref: EC:3.4
xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6"
xref: Reactome:R-HSA-3000243 "Unknown protease degrades GIF:Cbl to release Cbl"
+xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA"
+xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs"
xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion"
xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT"
+xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB"
xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)"
xref: Reactome:R-HSA-5655483 "USP1 autocleavage"
xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB"
xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC"
xref: Reactome:R-HSA-5693319 "CTRC hydrolyses PRSS1"
+xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)"
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
relationship: part_of GO:0006508 ! proteolysis
@@ -79755,7 +80003,7 @@ xref: Reactome:R-HSA-2022381 "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(
xref: Reactome:R-HSA-2467775 "Autocleavage of ESPL1 (Separase)"
xref: Reactome:R-HSA-2467809 "ESPL1 (Separase) cleaves centromeric cohesin"
xref: Reactome:R-HSA-5660752 "USP9X deubiquitinates Ub-SNCA"
-is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides
+is_a: GO:0008233 ! peptidase activity
[Term]
id: GO:0008235
@@ -79771,12 +80019,13 @@ name: serine-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
synonym: "serine protease activity" NARROW []
+xref: EC:3
xref: Reactome:R-HSA-1461993 "pro-HD5 is cleaved by trypsin"
xref: Reactome:R-HSA-2022383 "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"
xref: Reactome:R-HSA-3132753 "Pancreatic proteases degrade TCN1:Cbl"
xref: Reactome:R-HSA-6801766 "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)"
+is_a: GO:0008233 ! peptidase activity
is_a: GO:0017171 ! serine hydrolase activity
-is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides
[Term]
id: GO:0008237
@@ -79806,7 +80055,8 @@ xref: Reactome:R-HSA-5211405 "Anthrax LF cleaves target cell MAP2K6 (MEK6)"
xref: Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)"
xref: Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3"
xref: Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4"
-is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides
+xref: Reactome:R-HSA-9662837 "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163"
+is_a: GO:0008233 ! peptidase activity
[Term]
id: GO:0008238
@@ -79814,13 +80064,17 @@ name: exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE]
synonym: "exoprotease activity" NARROW []
-is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides
+is_a: GO:0008233 ! peptidase activity
[Term]
id: GO:0008239
name: dipeptidyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]
+xref: EC:3.4.14.11
+xref: EC:3.4.14.4
+xref: MetaCyc:3.4.14.11-RXN
+xref: MetaCyc:3.4.14.4-RXN
is_a: GO:0004177 ! aminopeptidase activity
[Term]
@@ -79829,10 +80083,11 @@ name: tripeptidyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]
xref: EC:3.4.14
+xref: EC:3.4.14.10
+xref: EC:3.4.14.9
xref: MetaCyc:3.4.14.10-RXN
xref: MetaCyc:3.4.14.9-RXN
-is_a: GO:0008236 ! serine-type peptidase activity
-is_a: GO:0008238 ! exopeptidase activity
+is_a: GO:0070009 ! serine-type aminopeptidase activity
[Term]
id: GO:0008241
@@ -79846,10 +80101,14 @@ is_a: GO:0008238 ! exopeptidase activity
id: GO:0008242
name: omega peptidase activity
namespace: molecular_function
-def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]
+def: "Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]
synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED []
xref: EC:3.4.19
-is_a: GO:0008238 ! exopeptidase activity
+xref: EC:3.4.19.2
+xref: EC:3.4.19.9
+xref: MetaCyc:3.4.19.9-RXN
+xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN
+is_a: GO:0008233 ! peptidase activity
[Term]
id: GO:0008243
@@ -79878,10 +80137,6 @@ synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "urokinase activity" RELATED [EC:3.4.21.-]
synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
-xref: EC:3.4.21.68
-xref: EC:3.4.21.73
-xref: MetaCyc:3.4.21.68-RXN
-xref: MetaCyc:3.4.21.73-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -79963,6 +80218,7 @@ synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31]
synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31]
xref: EC:3.1.3.31
xref: MetaCyc:NUCLEOTIDASE-RXN
+xref: RHEA:22140
is_a: GO:0016791 ! phosphatase activity
[Term]
@@ -80000,6 +80256,7 @@ xref: Reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG"
xref: Reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)"
xref: Reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+"
xref: Reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN"
+xref: RHEA:12484
is_a: GO:0008252 ! nucleotidase activity
[Term]
@@ -80014,6 +80271,7 @@ synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6]
synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6]
xref: EC:3.1.3.6
xref: MetaCyc:3-NUCLEOTID-RXN
+xref: RHEA:10144
is_a: GO:0008252 ! nucleotidase activity
[Term]
@@ -80034,6 +80292,7 @@ synonym: "HK2" RELATED [EC:2.7.13.1]
synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1]
xref: EC:2.7.13.1
xref: MetaCyc:2.7.13.1-RXN
+xref: RHEA:22720
is_a: GO:0004673 ! protein histidine kinase activity
[Term]
@@ -80047,6 +80306,7 @@ synonym: "HK3" RELATED [EC:2.7.13.2]
synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2]
xref: EC:2.7.13.2
xref: MetaCyc:2.7.13.2-RXN
+xref: RHEA:11860
is_a: GO:0004673 ! protein histidine kinase activity
[Term]
@@ -80402,9 +80662,7 @@ namespace: biological_process
def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752]
synonym: "acetylcholine metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0042133 ! neurotransmitter metabolic process
-is_a: GO:0042445 ! hormone metabolic process
is_a: GO:1900619 ! acetate ester metabolic process
[Term]
@@ -80418,7 +80676,6 @@ synonym: "acetylcholine formation" EXACT []
synonym: "acetylcholine synthesis" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:0042136 ! neurotransmitter biosynthetic process
-is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:1900620 ! acetate ester biosynthetic process
[Term]
@@ -80704,7 +80961,6 @@ namespace: molecular_function
def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "prenyl protein specific endopeptidase activity" EXACT []
-xref: EC:3.4.24
is_obsolete: true
replaced_by: GO:0004222
@@ -80718,10 +80974,13 @@ def: "Enables the transfer of a protein from one side of a membrane to the other
synonym: "protein channel activity" RELATED []
xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space"
xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix"
+xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex"
+xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane"
xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria"
xref: Reactome:R-HSA-5210943 "PA63:ANTRX2 oligomer transports EF and LF (target cell endosome to cytosol)"
xref: Reactome:R-HSA-5210947 "PA63:ANTRX1 oligomer transports EF and LF (target cell endosome to cytosol)"
xref: Reactome:R-HSA-5228406 "TeNT HC transports TeNT LC from target cell endosome membrane into cytosol"
+xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen"
xref: Reactome:R-HSA-5244404 "BoNT/B HC transports BoNT/B LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5244428 "BoNT/A HC transports BoNT/A LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5244506 "BoNT/E HC transports BoNT/E LC from target cell synaptic vesicle membrane into cytosol"
@@ -80730,6 +80989,7 @@ xref: Reactome:R-HSA-5250616 "BoNT/D HC transports BoNT/D LC from target cell sy
xref: Reactome:R-HSA-5250884 "BoNT/F HC transports BoNT/F LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5250972 "BoNT/G HC transports BoNT/G LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane"
+xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol"
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
is_a: GO:0140318 ! protein transporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity
@@ -80787,7 +81047,6 @@ id: GO:0008330
name: protein tyrosine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]
-xref: EC:3.1.3
is_a: GO:0004721 ! phosphoprotein phosphatase activity
[Term]
@@ -80858,7 +81117,7 @@ synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT []
xref: EC:1.14.11.1
xref: KEGG_REACTION:R02397
xref: MetaCyc:1.14.11.1-RXN
-xref: Reactome:R-HSA-71261 "BBOX1:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA"
+xref: Reactome:R-HSA-71261 "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA"
xref: RHEA:24028
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
@@ -80982,6 +81241,7 @@ synonym: "MAP4K activity" EXACT [PMID:20811974]
synonym: "MAPKKKK" EXACT []
xref: Reactome:R-HSA-177692 "Activation of recruited TAK1 within the activated TLR3 complex"
xref: Reactome:R-HSA-936991 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3"
+xref: Reactome:R-HSA-9645442 "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex"
is_a: GO:0004674 ! protein serine/threonine kinase activity
relationship: part_of GO:0000165 ! MAPK cascade
relationship: part_of GO:0000185 ! activation of MAPKKK activity
@@ -81034,6 +81294,7 @@ xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN
xref: Reactome:R-HSA-167191 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex"
xref: Reactome:R-HSA-170704 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex"
xref: Reactome:R-HSA-170706 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex"
+xref: RHEA:10216
is_a: GO:0004674 ! protein serine/threonine kinase activity
[Term]
@@ -81194,6 +81455,7 @@ id: GO:0008373
name: sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins." [GOC:cjm, PMID:26192491, Wikipedia:Sialyltransferase]
+xref: Reactome:R-HSA-9683769 "O-glycosylation of 3a is terminated"
xref: Reactome:R-HSA-981814 "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position"
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups
relationship: part_of GO:0097503 ! sialylation
@@ -81224,6 +81486,7 @@ def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-ac
synonym: "GlcNAc transferase activity" EXACT []
xref: Reactome:R-HSA-5694487 "A4GNT transfers GlcNAc to core 2 mucins"
xref: Reactome:R-HSA-8879117 "POMGNT2 transfers GlcNAc to Man-DAG1"
+xref: Reactome:R-HSA-9683648 "Spike trimer glycoside chains are extended"
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -81323,6 +81586,7 @@ xref: EC:2.7.11.10
xref: MetaCyc:2.7.11.10-RXN
xref: Reactome:R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex"
xref: Reactome:R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400"
+xref: RHEA:19073
is_a: GO:0004674 ! protein serine/threonine kinase activity
relationship: part_of GO:0007252 ! I-kappaB phosphorylation
@@ -81364,6 +81628,7 @@ xref: MetaCyc:1.14.15.6-RXN
xref: Reactome:R-HSA-193054 "Oxidation of cholesterol to 22beta-hydroxycholesterol"
xref: Reactome:R-HSA-193065 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol"
xref: Reactome:R-HSA-193101 "CYP11A1 cleaves 20a,22b-DHCHOL"
+xref: RHEA:35739
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
@@ -81459,6 +81724,7 @@ xref: Reactome:R-HSA-5602170 "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-tr
xref: Reactome:R-HSA-6785244 "Defective CYP11B2 does not oxidise 18HCORST"
xref: Reactome:R-HSA-6785245 "Defective CYP11B2 does not oxidise CORST"
xref: Reactome:R-HSA-9035960 "Defective CYP27A1 does not 27-hydroxylate 5-CHOL3,7,24(s)-triol"
+xref: RHEA:43836
is_a: GO:0004497 ! monooxygenase activity
[Term]
@@ -81624,6 +81890,7 @@ synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT []
synonym: "PHB polyprenyl diphosphate transferase activity" EXACT []
xref: EC:2.5.1
xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN
+xref: RHEA:27782
is_a: GO:0002094 ! polyprenyltransferase activity
[Term]
@@ -81689,6 +81956,7 @@ synonym: "long-chain-fatty-acyl-glutamate deacylase activity" EXACT []
synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55]
xref: EC:3.5.1.55
xref: MetaCyc:3.5.1.55-RXN
+xref: RHEA:17517
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -81727,8 +81995,6 @@ def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glyco
comment: This term was made obsolete because it represents a gene product.
synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40]
synonym: "bleomycin hydrolase activity" EXACT []
-xref: EC:3.4.22.40
-xref: MetaCyc:3.4.22.40-RXN
is_obsolete: true
replaced_by: GO:0004197
@@ -82071,8 +82337,6 @@ synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57]
synonym: "O-sialoglycoprotein endopeptidase activity" EXACT []
synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57]
synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57]
-xref: EC:3.4.24.57
-xref: MetaCyc:3.4.24.57-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -82087,8 +82351,6 @@ synonym: "aminopeptidase P" EXACT []
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9]
synonym: "X-Pro aminopeptidase activity" EXACT []
synonym: "Xaa-Pro aminopeptidase activity" EXACT []
-xref: EC:3.4.11.9
-xref: MetaCyc:3.4.11.9-RXN
is_obsolete: true
replaced_by: GO:0004177
@@ -82135,6 +82397,7 @@ synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosamin
xref: EC:2.4.1.145
xref: MetaCyc:2.4.1.145-RXN
xref: Reactome:R-HSA-975903 "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV"
+xref: RHEA:16057
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein
@@ -82179,6 +82442,7 @@ synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49]
synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49]
xref: EC:3.2.1.49
xref: MetaCyc:3.2.1.49-RXN
+xref: RHEA:15085
is_a: GO:0015929 ! hexosaminidase activity
[Term]
@@ -82259,8 +82523,6 @@ synonym: "ClpP" RELATED [EC:3.4.21.92]
synonym: "endopeptidase Clp activity" EXACT []
synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92]
synonym: "protease Ti activity" RELATED [EC:3.4.21.92]
-xref: EC:3.4.21.92
-xref: MetaCyc:3.4.21.92-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -82295,8 +82557,6 @@ synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9]
synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9]
synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9]
synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9]
-xref: EC:3.4.19.9
-xref: MetaCyc:3.4.19.9-RXN
is_obsolete: true
replaced_by: GO:0008242
@@ -82330,6 +82590,7 @@ xref: Reactome:R-HSA-3322014 "Autoglucosylation of GYG2 complexed with GYS2-a"
xref: Reactome:R-HSA-3322019 "Autoglucosylation of GYG2 complexed with GYS2-b"
xref: Reactome:R-HSA-3322025 "Autoglucosylation of GYG1 complexed with GYS1-a"
xref: Reactome:R-HSA-3814838 "Defective GYG1 is not autoglucosyolated"
+xref: RHEA:23360
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -82414,8 +82675,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22]
synonym: "gp180 (duck)" RELATED [EC:3.4.17.22]
synonym: "metallocarboxypeptidase D activity" EXACT []
-xref: EC:3.4.17.22
-xref: MetaCyc:3.4.17.22-RXN
is_obsolete: true
replaced_by: GO:0004181
@@ -82451,6 +82710,8 @@ xref: MetaCyc:3.1.2.22-RXN
xref: Reactome:R-HSA-203613 "depalmitoylation of eNOS"
xref: Reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins"
xref: Reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43"
+xref: Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated"
+xref: RHEA:19233
is_a: GO:0016790 ! thiolester hydrolase activity
is_a: GO:0098599 ! palmitoyl hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -82474,6 +82735,7 @@ synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4]
xref: EC:1.14.11.4
xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN
xref: Reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines"
+xref: RHEA:16569
is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity
[Term]
@@ -82488,6 +82750,9 @@ synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20]
xref: EC:2.8.2.20
xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-8954262 "TPST1,2 transfer SO4(2-) from PAPS to PODXL2"
+xref: Reactome:R-HSA-9668023 "TPST1,2 transfer SO4(2-) from PAPS to FVIII"
+xref: Reactome:R-HSA-9668148 "F8 variant is not sulfonated at Y1699"
+xref: RHEA:16801
is_a: GO:0008146 ! sulfotransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -82513,6 +82778,7 @@ synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1
synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1]
xref: EC:3.2.2.1
xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN
+xref: RHEA:23344
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
[Term]
@@ -82554,6 +82820,7 @@ synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29]
xref: EC:2.4.2.29
xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-6782443 "QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)"
+xref: RHEA:16633
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -82615,6 +82882,7 @@ def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-ox
synonym: "aminotransferase activity" EXACT []
xref: EC:2.6.1
xref: Reactome:R-HSA-1237102 "Transamination of MOB to methionine"
+xref: RHEA:31763
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups
[Term]
@@ -82667,6 +82935,7 @@ xref: Reactome:R-HSA-159826 "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin
xref: Reactome:R-HSA-163810 "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)"
xref: Reactome:R-HSA-163820 "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)"
xref: Reactome:R-HSA-6807214 "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)"
+xref: Reactome:R-HSA-9673231 "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX)"
xref: RHEA:45140
is_a: GO:0016831 ! carboxy-lyase activity
@@ -83002,7 +83271,8 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to
synonym: "sodium-dependent L-ascorbic acid transporter" RELATED []
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0005402 ! carbohydrate:cation symporter activity
-is_a: GO:0015229 ! L-ascorbic acid transmembrane transporter activity
+is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
+is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
[Term]
id: GO:0008521
@@ -83014,7 +83284,6 @@ xref: Reactome:R-HSA-5649742 "Defective SLC33A1 does not transport Ac-CoA from c
xref: Reactome:R-HSA-727759 "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:0015876 ! acetyl-CoA transport
@@ -83148,8 +83417,6 @@ synonym: "astacin activity" EXACT []
synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21]
synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21]
synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21]
-xref: EC:3.4.24.21
-xref: MetaCyc:3.4.24.21-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -83168,17 +83435,17 @@ synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23]
synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23]
synonym: "DNA glycosylase/AP-lyase activity" BROAD []
synonym: "DNA glycosylase/beta-lyase activity" BROAD []
-synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT []
-synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23]
-synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT []
+synonym: "DNA-formamidopyrimidine glycosylase activity" RELATED []
+synonym: "Fapy-DNA glycosylase activity" RELATED [EC:3.2.2.23]
+synonym: "formamidopyrimidine-DNA glycosylase activity" RELATED []
synonym: "Fpg protein" RELATED [EC:3.2.2.23]
synonym: "oxidized purine base lesion DNA N-glycosylase activity" EXACT []
synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
xref: EC:3.2.2.23
xref: MetaCyc:3.2.2.23-RXN
xref: Reactome:R-HSA-110229 "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase"
-xref: Reactome:R-HSA-110243 "Cleavage of 8-oxoguanine by OGG1 glycosylase"
-xref: Reactome:R-HSA-110244 "Cleavage of formamidopyrimidine (FapyG) by OGG1 glycosylase"
+xref: Reactome:R-HSA-110243 "Excision of 8-oxoguanine by OGG1 glycosylase"
+xref: Reactome:R-HSA-110244 "Excision of FapyG by OGG1 glycosylase"
is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity
[Term]
@@ -83448,7 +83715,6 @@ synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11]
synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11]
xref: EC:3.6.3.11
xref: MetaCyc:3.6.3.11-RXN
-xref: RHEA:24128
is_a: GO:0015108 ! chloride transmembrane transporter activity
is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity
@@ -83514,6 +83780,7 @@ xref: Reactome:R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to
xref: Reactome:R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate"
xref: Reactome:R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate"
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
+is_a: GO:0042910 ! xenobiotic transmembrane transporter activity
[Term]
id: GO:0008563
@@ -83546,9 +83813,6 @@ synonym: "enzyme transporter activity" NARROW []
synonym: "holin" RELATED []
synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb]
synonym: "secretin" RELATED []
-xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex"
-xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane"
-xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen"
is_obsolete: true
[Term]
@@ -83583,6 +83847,7 @@ synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT []
synonym: "katanin activity" NARROW [EC:5.6.1.1]
xref: EC:5.6.1.1
xref: MetaCyc:3.6.4.3-RXN
+xref: Reactome:R-HSA-9668419 "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites"
is_a: GO:0016887 ! ATPase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
relationship: part_of GO:0051013 ! microtubule severing
@@ -83932,6 +84197,7 @@ synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.2
xref: EC:2.5.1.26
xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN
xref: Reactome:R-HSA-390427 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate"
+xref: RHEA:36171
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
[Term]
@@ -83999,7 +84265,6 @@ def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydro
synonym: "pyridoxine metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
[Term]
@@ -84014,7 +84279,6 @@ synonym: "pyridoxine synthesis" EXACT []
is_a: GO:0008614 ! pyridoxine metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
[Term]
@@ -84076,6 +84340,7 @@ def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H
synonym: "chromatin accessibility complex" EXACT []
synonym: "ISW2 complex" NARROW []
is_a: GO:0031010 ! ISWI-type complex
+property_value: RO:0002161 NCBITaxon:4896
[Term]
id: GO:0008625
@@ -84456,6 +84721,7 @@ synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXA
synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16]
xref: EC:3.1.4.16
xref: MetaCyc:CYCPHOSDIESTER-RXN
+xref: RHEA:19621
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity
[Term]
@@ -84523,6 +84789,7 @@ synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34]
synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34]
xref: EC:1.3.1.34
xref: MetaCyc:DIENOYLCOAREDUCT-RXN
+xref: RHEA:12136
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -84793,6 +85060,7 @@ def: "Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen +
xref: EC:1.14.13
xref: KEGG_REACTION:R06786
xref: MetaCyc:MHPHYDROXY-RXN
+xref: RHEA:24785
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -85161,6 +85429,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+." [MetaCyc:RXN0-5061]
synonym: "ADP-heptose:LPS heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY]
xref: MetaCyc:RXN0-5061
+xref: RHEA:28538
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity
[Term]
@@ -85218,7 +85487,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "D-alanyl-D-alanine endopeptidase activity" EXACT []
synonym: "penicillin-binding protein 7" NARROW []
synonym: "penicillin-binding protein 8" NARROW []
-xref: EC:3.4.99
is_obsolete: true
replaced_by: GO:0004175
@@ -85271,12 +85539,13 @@ synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18]
synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18]
+synonym: "D-serine dehydration activity" RELATED []
synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18]
synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18]
xref: EC:4.3.1.18
xref: MetaCyc:DSERDEAM-RXN
-xref: Reactome:R-HSA-9014741 "SRR dimer:PXLP deaminates D-Ser"
-xref: Reactome:R-HSA-9034539 "SRR dimer:PXLP deaminates L-Ser"
+xref: Reactome:R-HSA-9014741 "PXLP-K56-SRR dimer deaminates D-Ser"
+xref: Reactome:R-HSA-9034539 "PXLP-K56-SRR dimer deaminates L-Ser"
xref: RHEA:13977
is_a: GO:0016841 ! ammonia-lyase activity
@@ -85321,6 +85590,7 @@ synonym: "SsuD" RELATED [EC:1.14.14.5]
synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5]
xref: EC:1.14.14.5
xref: MetaCyc:RXN0-280
+xref: RHEA:23064
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
[Term]
@@ -85329,6 +85599,7 @@ name: GDP-mannose mannosyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+." [MetaCyc:GDPMANMANHYDRO-RXN]
xref: MetaCyc:GDPMANMANHYDRO-RXN
+xref: RHEA:28102
is_a: GO:0015923 ! mannosidase activity
[Term]
@@ -85379,6 +85650,7 @@ synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT []
synonym: "LtaA" RELATED []
xref: EC:4.1.2
xref: MetaCyc:LTAA-RXN
+xref: RHEA:26209
is_a: GO:0004793 ! threonine aldolase activity
[Term]
@@ -85487,6 +85759,7 @@ synonym: "L-ribulokinase activity" EXACT []
synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16]
xref: EC:2.7.1.16
xref: MetaCyc:RIBULOKIN-RXN
+xref: RHEA:22072
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity
@@ -85614,6 +85887,7 @@ name: N-ethylmaleimide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+." [MetaCyc:RXN0-5101]
xref: MetaCyc:RXN0-5101
+xref: RHEA:35523
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -85725,6 +85999,7 @@ name: UDP-2,3-diacylglucosamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770]
xref: MetaCyc:LIPIDXSYNTHESIS-RXN
+xref: RHEA:25213
is_a: GO:0016462 ! pyrophosphatase activity
[Term]
@@ -85865,6 +86140,7 @@ def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-
comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10).
xref: EC:6.3.2
xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN
+xref: RHEA:28374
is_a: GO:0016881 ! acid-amino acid ligase activity
[Term]
@@ -85928,6 +86204,7 @@ synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14]
synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14]
xref: EC:3.1.4.14
xref: MetaCyc:3.1.4.14-RXN
+xref: RHEA:20537
is_a: GO:0008081 ! phosphoric diester hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -85945,6 +86222,7 @@ synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22]
xref: EC:6.2.1.22
xref: KEGG_REACTION:R04449
xref: MetaCyc:CITC-RXN
+xref: RHEA:23788
is_a: GO:0016878 ! acid-thiol ligase activity
[Term]
@@ -85965,6 +86243,7 @@ synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase/phosphatase activity" BROAD [EC:2.7.11.5]
xref: EC:2.7.11.5
xref: MetaCyc:PHOSICITDEHASE-RXN
+xref: RHEA:43540
is_a: GO:0004672 ! protein kinase activity
[Term]
@@ -85980,6 +86259,7 @@ synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT []
synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59]
xref: EC:2.7.7.59
xref: MetaCyc:URITRANS-RXN
+xref: RHEA:13673
is_a: GO:0070569 ! uridylyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -86029,6 +86309,7 @@ synonym: "AK activity" EXACT [EC:2.7.2.1]
synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1]
xref: EC:2.7.2.1
xref: MetaCyc:ACETATEKIN-RXN
+xref: RHEA:11352
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
@@ -86058,6 +86339,7 @@ synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXA
synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40]
xref: EC:2.3.1.40
xref: MetaCyc:ACYLGPEACYLTRANS-RXN
+xref: RHEA:10304
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -86073,6 +86355,7 @@ synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129]
synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129]
xref: EC:2.3.1.129
xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN
+xref: RHEA:13925
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -86123,6 +86406,7 @@ synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9]
xref: EC:3.2.2.9
xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN
+xref: RHEA:17805
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
[Term]
@@ -86271,6 +86555,7 @@ synonym: "aromatic aminotransferase activity" EXACT []
synonym: "aromatic-amino-acid transaminase activity" EXACT [EC:2.6.1.57]
xref: EC:2.6.1.57
xref: MetaCyc:2.6.1.57-RXN
+xref: RHEA:17533
xref: UM-BBD_reactionID:r0297
is_a: GO:0008483 ! transaminase activity
@@ -86282,6 +86567,7 @@ def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + ox
synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1]
xref: EC:1.20.4.1
xref: MetaCyc:RXN-982
+xref: RHEA:22016
xref: UM-BBD_reactionID:r0635
is_a: GO:0030611 ! arsenate reductase activity
is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor
@@ -86341,6 +86627,7 @@ xref: MetaCyc:3.4.19.5-RXN
xref: Reactome:R-HSA-5692495 "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)"
xref: Reactome:R-HSA-5696365 "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe"
is_a: GO:0008242 ! omega peptidase activity
+is_a: GO:0070003 ! threonine-type peptidase activity
[Term]
id: GO:0008800
@@ -86360,6 +86647,7 @@ synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6]
synonym: "penicillinase I, II" RELATED [EC:3.5.2.6]
xref: EC:3.5.2.6
xref: MetaCyc:BETA-LACTAMASE-RXN
+xref: RHEA:20401
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
[Term]
@@ -86448,6 +86736,7 @@ synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4]
synonym: "cytochrome b561" NARROW []
xref: EC:1.2.2.4
xref: MetaCyc:1.2.2.4-RXN
+xref: RHEA:13981
xref: UM-BBD_reactionID:r0650
xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561)
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor
@@ -86764,6 +87053,7 @@ synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cy
synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79]
xref: EC:2.1.1.79
xref: MetaCyc:2.1.1.79-RXN
+xref: RHEA:11988
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -86774,6 +87064,7 @@ def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite." [MetaC
synonym: "cysteine sulphinate desulphinase activity" EXACT []
xref: EC:4.4.1
xref: MetaCyc:RXN0-279
+xref: RHEA:28278
is_a: GO:0016846 ! carbon-sulfur lyase activity
[Term]
@@ -87067,8 +87358,6 @@ synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53]
synonym: "protease La" RELATED [EC:3.4.21.53]
synonym: "proteinase La" RELATED [EC:3.4.21.53]
synonym: "serine protease La" RELATED [EC:3.4.21.53]
-xref: EC:3.4.21.53
-xref: MetaCyc:3.4.21.53-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -87103,6 +87392,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+." [MetaCyc:RXN0-1661, PMID:4565531]
synonym: "enterobactin esterase activity" EXACT []
xref: MetaCyc:RXN0-1661
+xref: RHEA:28018
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds
[Term]
@@ -87223,6 +87513,7 @@ synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3]
synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3]
xref: EC:1.18.1.3
xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN
+xref: RHEA:16521
is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity
[Term]
@@ -87363,6 +87654,7 @@ synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18]
synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18]
xref: EC:2.3.1.18
xref: MetaCyc:GALACTOACETYLTRAN-RXN
+xref: RHEA:15713
is_a: GO:0016413 ! O-acetyltransferase activity
[Term]
@@ -87539,6 +87831,7 @@ synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT []
synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42]
xref: EC:2.7.7.42
xref: MetaCyc:GSADENYLATION-RXN
+xref: RHEA:18589
is_a: GO:0070566 ! adenylyltransferase activity
[Term]
@@ -87650,6 +87943,7 @@ xref: EC:3.1.4.46
xref: MetaCyc:GLYCPDIESTER-RXN
xref: Reactome:R-HSA-1483107 "GPETA is hydrolyzed to ETA and G3P by GPCPD1"
xref: Reactome:R-HSA-1483116 "GPCho is hydrolyzed to Cho and G3P by GPCPD1"
+xref: RHEA:12969
is_a: GO:0008081 ! phosphoric diester hydrolase activity
[Term]
@@ -87676,6 +87970,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide." [EC:1.1.3.15]
xref: MetaCyc:RXN-969
xref: Reactome:R-HSA-389842 "HAO1 tetramer oxidizes glycolate to glyoxylate"
+xref: RHEA:25311
is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity
[Term]
@@ -87763,6 +88058,7 @@ synonym: "PPTase activity" EXACT [EC:2.7.8.7]
xref: EC:2.7.8.7
xref: MetaCyc:HOLO-ACP-SYNTH-RXN
xref: Reactome:R-HSA-199202 "Phosphopantetheine conjugation of the ACP domain of FAS"
+xref: RHEA:12068
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
[Term]
@@ -87859,6 +88155,7 @@ synonym: "nickel-iron-selenium hydrogenase activity" NARROW []
synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2]
xref: EC:1.12.7.2
xref: MetaCyc:HYDROG-RXN
+xref: RHEA:17445
xref: UM-BBD_enzymeID:e0418
is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
@@ -87973,8 +88270,8 @@ id: GO:0008910
name: kanamycin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate." [EC:2.7.1.95, RHEA:24256]
-synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95]
-synonym: "APH(3') activity" EXACT [EC:2.7.1.95]
+synonym: "aminoglycoside 3'-phosphotransferase activity" BROAD [EC:2.7.1.95]
+synonym: "APH(3') activity" BROAD [EC:2.7.1.95]
synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95]
synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95]
synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95]
@@ -88032,6 +88329,7 @@ synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6]
xref: EC:2.3.2.6
xref: MetaCyc:LEUCYLTRANSFERASE-RXN
+xref: RHEA:12340
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
[Term]
@@ -88051,7 +88349,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
id: GO:0008917
name: lipopolysaccharide N-acetylglucosaminyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56, GOC:mr, KEGG:00540]
+def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56, GOC:mr]
synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT []
synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56]
synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56]
@@ -88065,7 +88363,7 @@ relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process
id: GO:0008918
name: lipopolysaccharide 3-alpha-galactosyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44, GOC:mr, KEGG:00540]
+def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44, GOC:mr]
synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "lipopolysaccharide galactosyltransferase activity" EXACT []
synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW []
@@ -88085,7 +88383,7 @@ relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process
id: GO:0008919
name: lipopolysaccharide glucosyltransferase I activity
namespace: molecular_function
-def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58, GOC:mr, KEGG:00540]
+def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58, GOC:mr]
synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
synonym: "LPS glucosyltransferase I activity" EXACT []
synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
@@ -88135,6 +88433,7 @@ synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20]
xref: EC:6.2.1.20
xref: KEGG_REACTION:R07325
xref: MetaCyc:ACYLACPSYNTH-RXN
+xref: RHEA:45588
is_a: GO:0015645 ! fatty acid ligase activity
[Term]
@@ -88452,8 +88751,6 @@ def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specifi
comment: This term was made obsolete because it represents a gene product.
synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70]
synonym: "oligopeptidase A activity" EXACT []
-xref: EC:3.4.24.70
-xref: MetaCyc:3.4.24.70-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -88466,8 +88763,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83]
synonym: "oligopeptidase B activity" EXACT []
synonym: "protease II activity" EXACT [EC:3.4.21.83]
-xref: EC:3.4.21.83
-xref: MetaCyc:3.4.21.83-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -88488,8 +88783,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87]
comment: This term was made obsolete because it represents a gene product.
synonym: "omptin activity" EXACT []
-xref: EC:3.4.21.87
-xref: MetaCyc:3.4.21.87-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -88544,6 +88837,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]." [MetaCyc:PALMITOTRANS-RXN]
synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT []
xref: MetaCyc:PALMITOTRANS-RXN
+xref: RHEA:44012
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -88588,6 +88882,7 @@ synonym: "PG-II activity" EXACT [EC:2.4.1.129]
synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129]
xref: EC:2.4.1.129
xref: MetaCyc:RXN0-5405
+xref: RHEA:23708
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -88688,6 +88983,7 @@ synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol
synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13]
xref: EC:2.7.8.13
xref: MetaCyc:RXN-8975
+xref: RHEA:21920
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
[Term]
@@ -88723,6 +89019,7 @@ synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3.
synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9]
xref: EC:2.7.3.9
xref: MetaCyc:2.7.3.9-RXN
+xref: RHEA:23880
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor
[Term]
@@ -88761,6 +89058,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969]
synonym: "phosphoheptose isomerase activity" EXACT []
xref: MetaCyc:RXN0-4301
+xref: RHEA:27489
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases
[Term]
@@ -88780,6 +89078,7 @@ xref: Reactome:R-HSA-1482892 "PE is hydrolyzed to 2-acyl LPE by PLA2G4C"
xref: Reactome:R-HSA-1482920 "PG is hydrolyzed to 2-acyl LPG by PLA2[14]"
xref: Reactome:R-HSA-1482932 "PI is hydrolyzed to 2-acyl LPI by PLA2[13]"
xref: Reactome:R-HSA-5694485 "ABHD3 hydrolyses LPC(14:0) to 1AGPC"
+xref: RHEA:18689
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity
@@ -88849,8 +89148,6 @@ synonym: "protease III activity" EXACT [EC:3.4.24.55]
synonym: "protease Pi activity" EXACT [EC:3.4.24.55]
synonym: "proteinase Pi" RELATED [EC:3.4.24.55]
synonym: "PTR" RELATED [EC:3.4.24.55]
-xref: EC:3.4.24.55
-xref: MetaCyc:3.4.24.55-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -88865,6 +89162,7 @@ synonym: "polyphosphate polymerase activity" EXACT []
synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1]
xref: EC:2.7.4.1
xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN
+xref: RHEA:19573
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
@@ -88889,8 +89187,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43]
comment: This term was made obsolete because it represents a gene product.
synonym: "prepilin peptidase activity" EXACT []
-xref: EC:3.4.23.43
-xref: MetaCyc:3.4.23.43-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -88914,6 +89210,7 @@ synonym: "PduW" RELATED []
synonym: "propanoate kinase activity" EXACT []
synonym: "TdcD" RELATED []
xref: EC:2.7.2.15
+xref: RHEA:23148
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
@@ -88987,6 +89284,7 @@ synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EX
xref: EC:2.1.1.80
xref: MetaCyc:CHER-RXN
xref: RESID:AA0072
+xref: RHEA:24452
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity
@@ -89004,6 +89302,7 @@ synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC:
xref: EC:3.1.1.61
xref: MetaCyc:MCPMETEST-RXN
xref: RESID:AA0072
+xref: RHEA:23236
is_a: GO:0051723 ! protein methylesterase activity
[Term]
@@ -89047,6 +89346,7 @@ name: quinolinate synthetase A activity
namespace: molecular_function
def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN]
xref: MetaCyc:QUINOLINATE-SYNTHA-RXN
+xref: RHEA:25888
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
relationship: part_of GO:0019805 ! quinolinate biosynthetic process
@@ -89097,7 +89397,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
synonym: "serine-type signal peptidase activity" EXACT []
-xref: EC:3.4.21
is_obsolete: true
replaced_by: GO:0004252
@@ -89110,8 +89409,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "LexA repressor" RELATED [EC:3.4.21.88]
synonym: "repressor lexA" RELATED [EC:3.4.21.88]
synonym: "repressor LexA activity" EXACT []
-xref: EC:3.4.21.88
-xref: MetaCyc:3.4.21.88-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -89192,6 +89489,7 @@ synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" E
synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128]
xref: EC:2.3.1.128
xref: MetaCyc:2.3.1.128-RXN
+xref: RHEA:43756
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity
[Term]
@@ -89204,7 +89502,7 @@ synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16]
synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16]
xref: EC:4.4.1.16
xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN
-xref: Reactome:R-HSA-2408524 "Sec is reduced to H2Se by SCLY"
+xref: Reactome:R-HSA-2408524 "Sec is reduced to H2Se by PXLP-K259-SCLY dimer"
xref: RHEA:11632
is_a: GO:0016846 ! carbon-sulfur lyase activity
@@ -89282,8 +89580,6 @@ synonym: "signal proteinase activity" EXACT [EC:3.4.21.89]
synonym: "signalase activity" EXACT [EC:3.4.21.89]
synonym: "SPase I activity" EXACT [EC:3.4.21.89]
synonym: "SPC" RELATED [EC:3.4.21.89]
-xref: EC:3.4.21.89
-xref: MetaCyc:3.4.21.89-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -89301,8 +89597,6 @@ synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "signal peptidase II activity" EXACT []
synonym: "SPase II activity" EXACT [EC:3.4.23.36]
-xref: EC:3.4.23.36
-xref: MetaCyc:3.4.23.36-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -89332,6 +89626,7 @@ synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72]
xref: EC:2.1.1.72
xref: MetaCyc:2.1.1.72-RXN
+xref: RHEA:15197
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity
relationship: part_of GO:0032775 ! DNA methylation on adenine
@@ -89350,7 +89645,6 @@ synonym: "DNA methylase" BROAD []
synonym: "DNA methyltransferase activity" EXACT []
synonym: "DNA transmethylase activity" EXACT []
synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37]
-xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3"
xref: Reactome:R-HSA-5227490 "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes"
is_a: GO:0008168 ! methyltransferase activity
is_a: GO:0140097 ! catalytic activity, acting on DNA
@@ -89388,19 +89682,19 @@ id: GO:0009011
name: starch synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21]
-synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
-synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
+synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT []
+synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT []
synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21]
-synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21]
+synonym: "ADP-glucose transglucosylase activity" EXACT []
synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
-synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21]
-synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21]
-synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
-synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
-synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21]
+synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT []
+synonym: "ADPG starch synthetase activity" EXACT []
+synonym: "ADPG-starch glucosyltransferase activity" EXACT []
+synonym: "ADPglucose-starch glucosyltransferase activity" EXACT []
+synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT []
synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21]
synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21]
-synonym: "starch synthetase activity" EXACT [EC:2.4.1.21]
+synonym: "starch synthetase activity" EXACT []
xref: EC:2.4.1.21
xref: MetaCyc:GLYCOGENSYN-RXN
is_a: GO:0046527 ! glucosyltransferase activity
@@ -89536,6 +89830,7 @@ synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
xref: EC:2.1.1.34
xref: MetaCyc:2.1.1.34-RXN
xref: Reactome:R-HSA-9024161 "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe)"
+xref: RHEA:20077
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity
is_a: GO:0106050 ! tRNA 2'-O-methyltransferase activity
@@ -89551,6 +89846,7 @@ synonym: "RNase PH activity" EXACT [EC:2.7.7.56]
synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56]
xref: EC:2.7.7.56
xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN
+xref: RHEA:10628
is_a: GO:0016779 ! nucleotidyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -89624,6 +89920,7 @@ synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93]
synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93]
xref: EC:1.1.1.93
xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN
+xref: RHEA:15209
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -89908,7 +90205,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
synonym: "aspartic-type signal peptidase activity" EXACT []
-xref: EC:3.4.23
is_obsolete: true
replaced_by: GO:0004190
@@ -89970,7 +90266,6 @@ synonym: "electron acceptor activity" NARROW []
synonym: "electron carrier" RELATED []
synonym: "electron donor activity" NARROW []
synonym: "electron transporter activity" RELATED []
-xref: Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster"
xref: Reactome:R-HSA-169260 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF"
xref: Reactome:R-HSA-2564826 "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold"
is_a: GO:0016491 ! oxidoreductase activity
@@ -90563,7 +90858,6 @@ synonym: "vitamin H biosynthesis" EXACT []
synonym: "vitamin H biosynthetic process" EXACT []
xref: MetaCyc:BIOTIN-SYNTHESIS-PWY
is_a: GO:0006768 ! biotin metabolic process
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
@@ -90582,6 +90876,7 @@ synonym: "lipopolysaccharide biosynthesis" EXACT []
synonym: "lipopolysaccharide formation" EXACT []
synonym: "lipopolysaccharide synthesis" EXACT []
synonym: "LPS biosynthetic process" EXACT []
+xref: KEGG_PATHWAY:map00540
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0008653 ! lipopolysaccharide metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
@@ -90611,7 +90906,6 @@ synonym: "lipoate metabolism" EXACT []
synonym: "lipoic acid metabolic process" EXACT []
synonym: "lipoic acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -90633,37 +90927,36 @@ synonym: "lipoic acid formation" EXACT []
synonym: "lipoic acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0009106 ! lipoate metabolic process
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
[Term]
id: GO:0009108
-name: coenzyme biosynthetic process
+name: obsolete coenzyme biosynthetic process
namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
+def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group biosynthetic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "coenzyme anabolism" EXACT []
synonym: "coenzyme and prosthetic group biosynthesis" BROAD []
synonym: "coenzyme and prosthetic group biosynthetic process" BROAD []
synonym: "coenzyme biosynthesis" EXACT []
synonym: "coenzyme formation" EXACT []
synonym: "coenzyme synthesis" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
-is_a: GO:0051188 ! cofactor biosynthetic process
+is_obsolete: true
[Term]
id: GO:0009109
-name: coenzyme catabolic process
+name: obsolete coenzyme catabolic process
namespace: biological_process
-def: "The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
+def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group catabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "coenzyme and prosthetic group catabolic process" BROAD []
synonym: "coenzyme and prosthetic group catabolism" BROAD []
synonym: "coenzyme breakdown" EXACT []
synonym: "coenzyme catabolism" EXACT []
synonym: "coenzyme degradation" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
-is_a: GO:0051187 ! cofactor catabolic process
+is_obsolete: true
[Term]
id: GO:0009110
@@ -91960,7 +92253,6 @@ synonym: "thiamine pyrophosphate biosynthesis" EXACT []
synonym: "thiamine pyrophosphate biosynthetic process" EXACT []
synonym: "TPP biosynthesis" EXACT []
synonym: "TPP biosynthetic process" EXACT []
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042357 ! thiamine diphosphate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
@@ -92015,7 +92307,6 @@ synonym: "vitamin G catabolism" EXACT []
is_a: GO:0006771 ! riboflavin metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042728 ! flavin-containing compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0009233
@@ -92060,9 +92351,7 @@ synonym: "vitamin B12 metabolic process" EXACT []
synonym: "vitamin B12 metabolism" EXACT []
synonym: "vitamin B12 reduction" NARROW []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
[Term]
id: GO:0009236
@@ -92078,7 +92367,6 @@ synonym: "vitamin B12 biosynthetic process" EXACT []
is_a: GO:0009235 ! cobalamin metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
[Term]
id: GO:0009237
@@ -92089,7 +92377,6 @@ synonym: "siderochrome metabolic process" NARROW []
synonym: "siderochrome metabolism" NARROW []
synonym: "siderophore metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
[Term]
id: GO:0009238
@@ -92101,7 +92388,7 @@ synonym: "enterochelin metabolic process" EXACT []
synonym: "enterochelin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process
-is_a: GO:0046483 ! heterocycle metabolic process
+is_a: GO:0033067 ! macrolide metabolic process
[Term]
id: GO:0009239
@@ -92122,8 +92409,8 @@ synonym: "enterochelin biosynthetic process" EXACT []
xref: MetaCyc:ENTBACSYN-PWY
is_a: GO:0009238 ! enterobactin metabolic process
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
-is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019540 ! siderophore biosynthetic process from catechol
+is_a: GO:0033068 ! macrolide biosynthetic process
[Term]
id: GO:0009240
@@ -92249,7 +92536,6 @@ alt_id: GO:0018055
def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118]
synonym: "peptidyl-lysine lipoylation" EXACT []
synonym: "protein-lipoic acid cofactor linkage" EXACT []
-is_a: GO:0018065 ! protein-cofactor linkage
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0051604 ! protein maturation
@@ -93392,11 +93678,9 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732]
synonym: "vitamin B7 binding" EXACT []
synonym: "vitamin H binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0019842 ! vitamin binding
is_a: GO:0033218 ! amide binding
is_a: GO:0033293 ! monocarboxylic acid binding
-is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding
@@ -93427,7 +93711,7 @@ def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in su
comment: This term was made obsolete because it represents a gene product.
synonym: "HslUV protease activity" EXACT []
is_obsolete: true
-replaced_by: GO:0070011
+replaced_by: GO:0008233
[Term]
id: GO:0009378
@@ -93605,7 +93889,6 @@ synonym: "vitamin B9 and derivative biosynthetic process" EXACT []
synonym: "vitamin M and derivative biosynthesis" EXACT []
synonym: "vitamin M and derivative biosynthetic process" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
@@ -93630,7 +93913,6 @@ synonym: "vitamin B9 and derivative catabolism" EXACT []
synonym: "vitamin M and derivative catabolic process" EXACT []
synonym: "vitamin M and derivative catabolism" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0042560 ! pteridine-containing compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
@@ -93644,7 +93926,6 @@ synonym: "FMN anabolism" EXACT []
synonym: "FMN biosynthesis" EXACT []
synonym: "FMN formation" EXACT []
synonym: "FMN synthesis" EXACT []
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process
is_a: GO:0042727 ! flavin-containing compound biosynthetic process
@@ -94093,7 +94374,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732]
synonym: "glycolate metabolism" EXACT []
xref: MetaCyc:GLYCOLATEMET-PWY
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
@@ -94174,7 +94454,6 @@ synonym: "GABA metabolism" EXACT []
synonym: "gamma-aminobutyric acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
-is_a: GO:0042133 ! neurotransmitter metabolic process
[Term]
id: GO:0009449
@@ -94194,7 +94473,6 @@ synonym: "gamma-aminobutyric acid formation" EXACT []
synonym: "gamma-aminobutyric acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
-is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
[Term]
@@ -94215,7 +94493,6 @@ synonym: "gamma-aminobutyric acid degradation" EXACT []
xref: MetaCyc:4AMINOBUTMETAB-PWY
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
-is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
[Term]
@@ -94563,6 +94840,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]." [MetaCyc:RXN0-5268]
xref: EC:1.10.3
xref: MetaCyc:RXN0-5268
+xref: RHEA:30251
is_a: GO:0015002 ! heme-copper terminal oxidase activity
[Term]
@@ -94673,6 +94951,7 @@ synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC:
xref: EC:1.10.9.1
xref: KEGG_REACTION:R03817
xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN
+xref: RHEA:22148
is_a: GO:0052880 ! oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor
[Term]
@@ -96375,7 +96654,6 @@ synonym: "gibberellic acid metabolism" NARROW []
synonym: "gibberellin metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:0042445 ! hormone metabolic process
[Term]
id: GO:0009686
@@ -96394,7 +96672,6 @@ xref: MetaCyc:PWY-5052
xref: MetaCyc:PWY-5070
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
-is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
[Term]
@@ -96469,7 +96746,6 @@ def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a
synonym: "ethene metabolic process" EXACT []
synonym: "ethene metabolism" EXACT []
synonym: "ethylene metabolism" EXACT []
-is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process
[Term]
@@ -96490,7 +96766,6 @@ synonym: "ethylene formation" EXACT []
synonym: "ethylene synthesis" EXACT []
xref: MetaCyc:ETHYL-PWY
is_a: GO:0009692 ! ethylene metabolic process
-is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0043450 ! alkene biosynthetic process
[Term]
@@ -96500,7 +96775,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845]
synonym: "jasmonic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
-is_a: GO:0042445 ! hormone metabolic process
[Term]
id: GO:0009695
@@ -96513,7 +96787,6 @@ synonym: "jasmonic acid formation" EXACT []
synonym: "jasmonic acid synthesis" EXACT []
xref: MetaCyc:PWY-735
is_a: GO:0009694 ! jasmonic acid metabolic process
-is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
[Term]
@@ -96522,10 +96795,8 @@ name: salicylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399]
synonym: "salicylic acid metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
-is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
[Term]
@@ -96540,8 +96811,6 @@ synonym: "salicylic acid formation" EXACT []
synonym: "salicylic acid synthesis" EXACT []
xref: MetaCyc:PWY-981
is_a: GO:0009696 ! salicylic acid metabolic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
-is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
@@ -96980,7 +97249,6 @@ name: response to abscisic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl]
synonym: "response to abscisic acid stimulus" EXACT [GOC:dos]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009725 ! response to hormone
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
@@ -97005,7 +97273,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl]
synonym: "response to gibberellic acid stimulus" NARROW []
synonym: "response to gibberellin stimulus" EXACT [GOC:dos]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009725 ! response to hormone
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -97113,11 +97380,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl]
synonym: "response to salicylate" EXACT [GOC:dph]
synonym: "response to salicylic acid stimulus" EXACT [GOC:dos]
-is_a: GO:0001101 ! response to acid chemical
-is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound
[Term]
@@ -97135,7 +97398,6 @@ name: response to jasmonic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl]
synonym: "response to jasmonic acid stimulus" EXACT [GOC:dos]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009725 ! response to hormone
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -98462,8 +98724,6 @@ synonym: "red-sensitive opsin" NARROW []
synonym: "short-wave-sensitive opsin" NARROW []
synonym: "UV-sensitive opsin" NARROW []
synonym: "violet-sensitive opsin" NARROW []
-xref: Reactome:R-HSA-2465917 "Photons induce isomerisation of 11c-retinyl to at-retinyl"
-xref: Reactome:R-HSA-74101 "Photons induce isomerization of 11c-retinyl to at-retinyl"
is_a: GO:0038023 ! signaling receptor activity
[Term]
@@ -99483,6 +99743,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [MetaCyc:RXN-5962, PMID:8837513]
xref: EC:1.14.99
xref: MetaCyc:RXN-5962
+xref: RHEA:57352
is_a: GO:0072374 ! carotene epsilon hydroxylase activity
[Term]
@@ -99523,6 +99784,7 @@ synonym: "HPI" RELATED [EC:4.2.1.92]
synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92]
synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92]
xref: MetaCyc:RXN1F-19
+xref: RHEA:25074
is_a: GO:0016836 ! hydro-lyase activity
[Term]
@@ -99544,8 +99806,6 @@ synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11]
synonym: "glutamate carboxypeptidase activity" EXACT []
synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11]
synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11]
-xref: EC:3.4.17.11
-xref: MetaCyc:3.4.17.11-RXN
is_obsolete: true
replaced_by: GO:0004180
@@ -99948,7 +100208,6 @@ synonym: "proanthocyanidin formation" EXACT []
synonym: "proanthocyanidin synthesis" EXACT []
xref: MetaCyc:PWY-641
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
@@ -99962,7 +100221,6 @@ synonym: "phytochromobilin biosynthesis" EXACT []
synonym: "phytochromobilin formation" EXACT []
synonym: "phytochromobilin synthesis" EXACT []
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0051202 ! phytochromobilin metabolic process
[Term]
@@ -100065,9 +100323,7 @@ id: GO:0010034
name: response to acetate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010033 ! response to organic substance
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound
[Term]
@@ -100091,7 +100347,6 @@ name: response to carbon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm]
is_a: GO:0010033 ! response to organic substance
-is_a: GO:0072347 ! response to anesthetic
is_a: GO:1901700 ! response to oxygen-containing compound
[Term]
@@ -100957,8 +101212,6 @@ synonym: "phenylacetate breakdown" EXACT []
synonym: "phenylacetate catabolism" EXACT []
synonym: "phenylacetate degradation" EXACT []
xref: MetaCyc:PWY0-321
-is_a: GO:0009407 ! toxin catabolic process
-is_a: GO:0009852 ! auxin catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -100978,7 +101231,6 @@ xref: MetaCyc:PWY1G-0
is_a: GO:0010126 ! mycothiol metabolic process
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
[Term]
id: GO:0010126
@@ -100988,7 +101240,6 @@ def: "The chemical reactions and pathways involving mycothiol, which consists of
synonym: "mycothiol metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0016137 ! glycoside metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
[Term]
id: GO:0010127
@@ -101332,7 +101583,6 @@ id: GO:0010157
name: response to chlorate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -101416,7 +101666,6 @@ id: GO:0010167
name: response to nitrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -101477,6 +101726,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol." [MetaCyc:RXN-2541, PMID:14512521]
xref: KEGG_REACTION:R07500
xref: MetaCyc:RXN-2541
+xref: RHEA:37975
is_a: GO:0010354 ! homogentisate prenyltransferase activity
[Term]
@@ -101520,7 +101770,6 @@ def: "Interacting selectively and non-covalently with flavin mono nucleotide. Fl
synonym: "flavin mononucleotide binding" EXACT []
is_a: GO:0032553 ! ribonucleotide binding
is_a: GO:0043168 ! anion binding
-is_a: GO:0050662 ! coenzyme binding
[Term]
id: GO:0010182
@@ -101652,10 +101901,7 @@ name: response to ozone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm]
is_a: GO:0000302 ! response to reactive oxygen species
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
[Term]
id: GO:0010194
@@ -101723,7 +101969,6 @@ name: response to chitin
namespace: biological_process
def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm]
is_a: GO:0010243 ! response to organonitrogen compound
-is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
[Term]
@@ -102111,6 +102356,7 @@ def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxyg
synonym: "photosynthetic water oxidation" EXACT []
xref: MetaCyc:PSII-RXN
xref: MetaCyc:RXN0-5265
+xref: RHEA:36359
is_a: GO:0016491 ! oxidoreductase activity
[Term]
@@ -102321,7 +102567,6 @@ synonym: "response to thiamine" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
-is_a: GO:0042493 ! response to drug
[Term]
id: GO:0010267
@@ -102402,6 +102647,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+." [MetaCyc:RXN-7683]
xref: EC:2.7.1
xref: MetaCyc:RXN-7683
+xref: RHEA:38055
is_a: GO:0016301 ! kinase activity
[Term]
@@ -102576,6 +102822,7 @@ name: abscisic acid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062]
xref: MetaCyc:RXN-8155
+xref: RHEA:31031
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -102601,6 +102848,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+." [MetaCyc:RXN-8409, PMID:16870359]
xref: EC:3.1.1
xref: MetaCyc:RXN-8409
+xref: RHEA:48520
is_a: GO:0051723 ! protein methylesterase activity
[Term]
@@ -102617,6 +102865,7 @@ name: dihydrocamalexic acid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+." [MetaCyc:RXN-8275, PMID:16766671]
xref: MetaCyc:RXN-8275
+xref: RHEA:34807
is_a: GO:0016831 ! carboxy-lyase activity
[Term]
@@ -102730,7 +102979,6 @@ name: regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119]
synonym: "regulation of hydrogen peroxide metabolism" EXACT []
-is_a: GO:0051193 ! regulation of cofactor metabolic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0042743 ! hydrogen peroxide metabolic process
@@ -102989,7 +103237,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119]
synonym: "regulation of salicylic acid metabolism" RELATED []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
-is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0009696 ! salicylic acid metabolic process
relationship: regulates GO:0009696 ! salicylic acid metabolic process
@@ -103079,6 +103326,7 @@ name: L-galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667]
xref: MetaCyc:RXNQT-4142
+xref: RHEA:26349
is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity
[Term]
@@ -103097,6 +103345,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629]
synonym: "L-galactose 1-dehydrogenase activity" RELATED []
xref: MetaCyc:RXN-1884
+xref: RHEA:31559
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
[Term]
@@ -103234,8 +103483,8 @@ id: GO:0010364
name: regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators]
+is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
-is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:1900911 ! regulation of olefin biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0009693 ! ethylene biosynthetic process
@@ -103247,8 +103496,8 @@ name: positive regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0010364 ! regulation of ethylene biosynthetic process
+is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process
-is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:1900913 ! positive regulation of olefin biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0009693 ! ethylene biosynthetic process
@@ -103260,8 +103509,8 @@ name: negative regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0010364 ! regulation of ethylene biosynthetic process
+is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process
-is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:1900912 ! negative regulation of olefin biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0009693 ! ethylene biosynthetic process
@@ -103309,8 +103558,8 @@ def: "Any process that modulates the frequency, rate or extent of the chemical r
synonym: "regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
+is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
-is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0009686 ! gibberellin biosynthetic process
@@ -103323,8 +103572,8 @@ namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "positive regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010371 ! regulation of gibberellin biosynthetic process
+is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
-is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -103338,7 +103587,7 @@ namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010371 ! regulation of gibberellin biosynthetic process
-is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
+is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
@@ -103480,7 +103729,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators]
synonym: "glucomannan metabolism" EXACT []
is_a: GO:0006080 ! substituted mannan metabolic process
-is_a: GO:0017144 ! drug metabolic process
[Term]
id: GO:0010392
@@ -105227,7 +105475,6 @@ namespace: biological_process
def: "The controlled release of glutamine by a cell." [PMID:15208395]
is_a: GO:0006868 ! glutamine transport
is_a: GO:0032940 ! secretion by cell
-is_a: GO:0046717 ! acid secretion
[Term]
id: GO:0010586
@@ -106729,7 +106976,6 @@ namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process
@@ -106742,7 +106988,6 @@ namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process
@@ -107445,7 +107690,6 @@ name: regulation of ubiquinone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0006744 ! ubiquinone biosynthetic process
relationship: regulates GO:0006744 ! ubiquinone biosynthetic process
@@ -107623,7 +107867,6 @@ id: GO:0010815
name: bradykinin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:BHF, GOC:rl]
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0043171 ! peptide catabolic process
[Term]
@@ -107633,7 +107876,6 @@ namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl]
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042447 ! hormone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0043171 ! peptide catabolic process
[Term]
@@ -109016,7 +109258,8 @@ is_a: GO:0045892 ! negative regulation of transcription, DNA-templated
id: GO:0010945
name: CoA pyrophosphatase activity
namespace: molecular_function
-def: "Catalysis of the reaction: coenzyme A + H2O = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb]
+def: "Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb, PMID:10922370, PMID:16185196]
+synonym: "conezyme A pyrophosphatase activity" RELATED []
is_a: GO:0016462 ! pyrophosphatase activity
created_by: tb
creation_date: 2009-04-22T02:06:40Z
@@ -109148,7 +109391,6 @@ name: negative regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010957 ! negative regulation of vitamin D biosynthetic process
-is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
@@ -109239,7 +109481,6 @@ name: regulation of L-arginine import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:dph, GOC:tb]
is_a: GO:0051955 ! regulation of amino acid transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1902023 ! L-arginine transport
relationship: regulates GO:1902023 ! L-arginine transport
@@ -110306,7 +110547,6 @@ def: "The controlled release of glutamate by a cell. The glutamate is the most a
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0032940 ! secretion by cell
-is_a: GO:0046717 ! acid secretion
[Term]
id: GO:0014048
@@ -110368,7 +110608,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "regulation of GABA secretion" EXACT []
is_a: GO:0051046 ! regulation of secretion
-is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0014051 ! gamma-aminobutyric acid secretion
@@ -110386,7 +110625,6 @@ synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW []
synonym: "negative regulation of GABA secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0051048 ! negative regulation of secretion
-is_a: GO:0051589 ! negative regulation of neurotransmitter transport
is_a: GO:0051956 ! negative regulation of amino acid transport
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion
@@ -110405,7 +110643,6 @@ synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0051047 ! positive regulation of secretion
-is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:0051957 ! positive regulation of amino acid transport
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion
@@ -110431,7 +110668,6 @@ is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0043269 ! regulation of ion transport
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051952 ! regulation of amine transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: regulates GO:0014055 ! acetylcholine secretion, neurotransmission
@@ -110451,7 +110687,6 @@ is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission
is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic
is_a: GO:0043270 ! positive regulation of ion transport
is_a: GO:0051954 ! positive regulation of amine transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission
@@ -110470,7 +110705,6 @@ is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051953 ! negative regulation of amine transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission
@@ -110484,7 +110718,6 @@ is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0043269 ! regulation of ion transport
is_a: GO:0050433 ! regulation of catecholamine secretion
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0014046 ! dopamine secretion
relationship: regulates GO:0014046 ! dopamine secretion
@@ -110522,7 +110755,6 @@ synonym: "regulation of serotonin release" RELATED [GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0043269 ! regulation of ion transport
-is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0001820 ! serotonin secretion
@@ -110542,7 +110774,6 @@ is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0043271 ! negative regulation of ion transport
-is_a: GO:0051589 ! negative regulation of neurotransmitter transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0001820 ! serotonin secretion
@@ -110563,7 +110794,6 @@ is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0043270 ! positive regulation of ion transport
-is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0001820 ! serotonin secretion
@@ -110714,7 +110944,6 @@ comment: Note that this term is in the subset of terms that should not be used f
subset: gocheck_do_not_manually_annotate
synonym: "response to selective serotonin reuptake inhibitor" RELATED []
synonym: "response to SSRI" RELATED []
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0036276 ! response to antidepressant
[Term]
@@ -111373,7 +111602,7 @@ name: artery smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MSH:D001158]
is_a: GO:0014820 ! tonic smooth muscle contraction
-is_a: GO:0014829 ! vascular smooth muscle contraction
+is_a: GO:0014829 ! vascular associated smooth muscle contraction
[Term]
id: GO:0014825
@@ -111388,7 +111617,7 @@ name: vein smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MSH:D014680]
is_a: GO:0014821 ! phasic smooth muscle contraction
-is_a: GO:0014829 ! vascular smooth muscle contraction
+is_a: GO:0014829 ! vascular associated smooth muscle contraction
[Term]
id: GO:0014827
@@ -111408,9 +111637,10 @@ is_a: GO:0120063 ! stomach smooth muscle contraction
[Term]
id: GO:0014829
-name: vascular smooth muscle contraction
+name: vascular associated smooth muscle contraction
namespace: biological_process
def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718]
+synonym: "vascular smooth muscle contraction" EXACT []
is_a: GO:0006939 ! smooth muscle contraction
is_a: GO:0042310 ! vasoconstriction
@@ -112227,7 +112457,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732]
synonym: "corrin metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
[Term]
id: GO:0015010
@@ -112244,7 +112473,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, Wikipedia:Cofactor_F430]
synonym: "coenzyme F430 metabolic process" NARROW []
synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
[Term]
@@ -112342,6 +112570,7 @@ synonym: "PAPS:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8]
xref: EC:2.8.2.8
xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-2022860 "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)"
+xref: RHEA:21980
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity
[Term]
@@ -112367,6 +112596,7 @@ xref: MetaCyc:2.4.1.135-RXN
xref: Reactome:R-HSA-1889955 "B3GAT dimers transfer GlcA to tetrasaccharide linker"
xref: Reactome:R-HSA-3560802 "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker"
xref: Reactome:R-HSA-9638064 "B3GAT3 dimer transfers GlcA to tetrasaccharide linker"
+xref: RHEA:24168
is_a: GO:0015020 ! glucuronosyltransferase activity
[Term]
@@ -112383,6 +112613,7 @@ xref: Reactome:R-HSA-1678660 "HGSNAT oligomer acetylates Heparan sulfate chain(3
xref: Reactome:R-HSA-2090085 "HGSNAT oligomer acetylates Heparan chain(1)"
xref: Reactome:R-HSA-2263492 "Defective HGSNAT does not acetylate Heparan chain(1)"
xref: Reactome:R-HSA-9036056 "Defective HGSNAT does not acetylate Heparan sulfate chain(3)"
+xref: RHEA:15125
is_a: GO:0008080 ! N-acetyltransferase activity
[Term]
@@ -112463,6 +112694,7 @@ xref: Reactome:R-HSA-9036104 "Defective UGT1A4 does not transfer GlcA from UDP-G
xref: Reactome:R-HSA-9632038 "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG"
xref: Reactome:R-HSA-9632039 "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG"
xref: Reactome:R-HSA-9638097 "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA"
+xref: RHEA:21032
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -112643,6 +112875,7 @@ synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd]
synonym: "NADPH:adrenodoxin oxidoreductase activity" EXACT [EC:1.18.1.2]
xref: EC:1.18.1.6
xref: MetaCyc:RXN-13685
+xref: RHEA:42312
is_a: GO:0016491 ! oxidoreductase activity
[Term]
@@ -112699,7 +112932,7 @@ is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as a
id: GO:0015044
name: rubredoxin-NAD+ reductase activity
namespace: molecular_function
-def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1]
+def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1, RHEA:18597]
synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "DPNH-rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "NADH--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1]
@@ -112712,6 +112945,7 @@ synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" EXAC
synonym: "rubredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.1]
xref: EC:1.18.1.1
xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN
+xref: RHEA:18597
is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity
[Term]
@@ -112732,10 +112966,11 @@ is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as do
[Term]
id: GO:0015046
-name: rubredoxin-NADP reductase activity
+name: rubredoxin-NADP+ reductase activity
namespace: molecular_function
-def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [EC:1.18.1.-]
+def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [RHEA:13949]
xref: EC:1.18.1
+xref: RHEA:13949
is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity
[Term]
@@ -112748,6 +112983,7 @@ synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" EXACT [EC:1.6.2.5]
synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.6.2.5]
xref: EC:1.6.2.5
xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN
+xref: RHEA:15237
is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
[Term]
@@ -113321,6 +113557,7 @@ name: bicarbonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai]
xref: Reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region"
+xref: RHEA:28695
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity
relationship: part_of GO:0015701 ! bicarbonate transport
@@ -113424,6 +113661,7 @@ synonym: "sulphate transporter activity" EXACT []
xref: Reactome:R-HSA-3560789 "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol"
xref: Reactome:R-HSA-427555 "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-8875871 "SLC26A11 transports SO4(2-) from extracellular region to cytosol"
+xref: RHEA:34983
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:1902358 ! sulfate transmembrane transport
@@ -113495,8 +113733,8 @@ def: "Enables the transfer of bile acid from one side of a membrane to the other
xref: Reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol"
xref: Reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol"
xref: Reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A"
-xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport ALB:(GCCA,TCCA) from extracellular region to cytosol"
-xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport ALB:(GCCA, TCCA) from extracellular region to cytosol"
+xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)"
+xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)"
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
@@ -113517,6 +113755,7 @@ namespace: molecular_function
def: "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684]
xref: Reactome:R-HSA-5679031 "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region"
xref: Reactome:R-HSA-5679041 "ABCC2 transports BMG,BDG from cytosol to extracellular region"
+xref: Reactome:R-HSA-9661417 "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region"
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
relationship: part_of GO:0015723 ! bilirubin transport
@@ -114072,7 +114311,6 @@ def: "Enables the transfer of L-aspartate from one side of a membrane to the oth
synonym: "glutamate/aspartate porter activity" NARROW []
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "L-aspartate transporter activity" BROAD []
-is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity
@@ -114100,7 +114338,6 @@ synonym: "4-aminobutanoate transporter activity" EXACT []
synonym: "4-aminobutyrate transporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" NARROW []
synonym: "GABA transporter activity" EXACT []
-is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0015812 ! gamma-aminobutyric acid transport
@@ -114124,7 +114361,6 @@ def: "Enables the transfer of glycine from one side of a membrane to the other.
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "glycine transporter activity" BROAD []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
-is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
@@ -114312,6 +114548,7 @@ namespace: molecular_function
def: "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators]
xref: Reactome:R-HSA-163215 "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane"
xref: Reactome:R-HSA-5672027 "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane"
+xref: RHEA:34999
is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity
relationship: part_of GO:0015853 ! adenine transport
@@ -114430,7 +114667,6 @@ xref: Reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellula
xref: Reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol"
xref: Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix"
-is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
relationship: part_of GO:0015871 ! choline transport
@@ -114454,7 +114690,6 @@ comment: This term was made obsolete because it was replaced by more specific te
synonym: "vitamin or cofactor transporter activity" EXACT []
synonym: "vitamin/cofactor transporter activity" EXACT []
is_obsolete: true
-consider: GO:0051184
consider: GO:0090482
[Term]
@@ -114463,7 +114698,7 @@ name: biopterin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732]
synonym: "biopterin transporter activity" RELATED []
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
+is_a: GO:0022857 ! transmembrane transporter activity
relationship: part_of GO:0015877 ! biopterin transport
[Term]
@@ -114478,7 +114713,6 @@ synonym: "vitamin H transporter activity" RELATED []
xref: RHEA:28458
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:0015878 ! biotin transport
@@ -114516,7 +114750,6 @@ namespace: molecular_function
def: "Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai]
synonym: "coenzyme A transporter activity" BROAD []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity
relationship: part_of GO:0035349 ! coenzyme A transmembrane transport
@@ -114527,10 +114760,9 @@ namespace: molecular_function
def: "Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ISBN:0198506732]
synonym: "L-ascorbate transporter activity" EXACT []
synonym: "vitamin C transporter activity" EXACT []
-xref: Reactome:R-HSA-198870 "SVCT1/2 cotransports extracellular VitC and 2Na+ to cytosol"
+xref: Reactome:R-HSA-198870 "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol"
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
relationship: part_of GO:0015882 ! L-ascorbic acid transmembrane transport
@@ -114548,7 +114780,6 @@ synonym: "flavin-adenine dinucleotide carrier activity" RELATED []
synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
relationship: part_of GO:0035350 ! FAD transmembrane transport
[Term]
@@ -114564,18 +114795,17 @@ relationship: part_of GO:0015885 ! 5-formyltetrahydrofolate transport
[Term]
id: GO:0015232
-name: heme transporter activity
+name: heme transmembrane transporter activity
namespace: molecular_function
-def: "Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells." [GOC:ai]
+def: "Enables the transfer of heme from one side of a membrane to the other." [PMID:29549126]
synonym: "haem transporter activity" EXACT []
-xref: Reactome:R-HSA-1369065 "ABCB6 transports porphyrin from cytosol to mitchondrial matrix"
-xref: Reactome:R-HSA-382560 "ABC7, mABC1 and mABC2 mediate heme transport"
-xref: Reactome:R-HSA-5683355 "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix"
+synonym: "heme transporter activity" BROAD []
xref: Reactome:R-HSA-917870 "SLC46A1 transports FeHM from extracellular region to cytosol"
-xref: Reactome:R-HSA-917892 "FLVCR transports heme from cytosol to extracellular region"
-xref: Reactome:R-HSA-917979 "ABCG2 dimer transports heme from cytosol to extracellular region"
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
+xref: Reactome:R-HSA-917892 "FLVCR1-1 transports heme from cytosol to extracellular region"
+xref: Reactome:R-HSA-9661408 "FLVCR1-2 transports heme from mitochondrial matrix to cytosol"
+is_a: GO:0022857 ! transmembrane transporter activity
relationship: part_of GO:0015886 ! heme transport
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19472 xsd:anyURI
[Term]
id: GO:0015233
@@ -114586,7 +114816,6 @@ synonym: "pantothenate transporter activity" BROAD [GOC:mah]
synonym: "vitamin B5 transmembrane transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
relationship: part_of GO:0015887 ! pantothenate transmembrane transport
@@ -114605,6 +114834,7 @@ synonym: "thiamine permease activity" EXACT []
synonym: "thiamine uptake transmembrane transporter activity" RELATED []
synonym: "vitamin B1 transporter activity" EXACT []
xref: Reactome:R-HSA-199626 "SLC19A2/3 transport extracellular THMN to cytosol"
+xref: RHEA:34919
is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
@@ -114637,7 +114867,6 @@ namespace: molecular_function
def: "Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators]
synonym: "fluconazole transporter activity" RELATED []
is_a: GO:0015665 ! alcohol transmembrane transporter activity
-is_a: GO:0042910 ! xenobiotic transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
relationship: part_of GO:0015903 ! fluconazole transport
@@ -114653,6 +114882,7 @@ synonym: "fatty-acyl group transporter activity" BROAD []
synonym: "peroxisomal fatty acyl transporter" NARROW []
xref: Reactome:R-HSA-5627891 "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol"
xref: Reactome:R-HSA-879585 "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol"
+xref: RHEA:33655
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
relationship: part_of GO:0015908 ! fatty acid transport
@@ -114679,6 +114909,7 @@ xref: Reactome:R-HSA-5679101 "Defective ABCG8 (in ABCG5:ABCG8) does not transpor
xref: Reactome:R-HSA-5679145 "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region"
xref: Reactome:R-HSA-8867667 "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane"
xref: Reactome:R-HSA-8868402 "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane"
+xref: RHEA:39747
is_a: GO:0005319 ! lipid transporter activity
relationship: part_of GO:0015918 ! sterol transport
@@ -114695,6 +114926,7 @@ xref: Reactome:R-HSA-432067 "Aquaporin-4 passively transports water out of cell"
xref: Reactome:R-HSA-445714 "Aquaporin-3 passively transports water out of cell"
xref: Reactome:R-HSA-507868 "Aquaporins passively transport water into cells"
xref: Reactome:R-HSA-507870 "Aquaporins passively transport water out of cells"
+xref: RHEA:29667
is_a: GO:0005372 ! water transmembrane transporter activity
is_a: GO:0015267 ! channel activity
@@ -114735,6 +114967,7 @@ xref: Reactome:R-HSA-432049 "Aquaporin-9 passively transports glycerol into cell
xref: Reactome:R-HSA-432074 "Aquaporin-7 passively transports glycerol out of cell"
xref: Reactome:R-HSA-507869 "Aquaporins passively transport glycerol into cells"
xref: Reactome:R-HSA-507871 "Aquaporins passively transport glycerol out of cells"
+xref: RHEA:29675
is_a: GO:0015168 ! glycerol transmembrane transporter activity
is_a: GO:0015267 ! channel activity
@@ -114856,6 +115089,7 @@ synonym: "pore class transporter activity" RELATED []
synonym: "substrate-specific channel activity" RELATED []
xref: Reactome:R-HSA-3779381 "H2O2 diffuses from the mitochondrial matrix to the cytosol"
xref: Reactome:R-HSA-8953430 "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix"
+xref: RHEA:29447
xref: TC:1
is_a: GO:0022803 ! passive transmembrane transporter activity
@@ -114907,7 +115141,7 @@ def: "Enables the transmembrane transfer of an ion by a channel that opens when
synonym: "ionotropic receptor activity" NARROW [GOC:bf, GOC:sart]
xref: Reactome:R-HSA-451310 "Activation of Edited Kainate receptors"
xref: Reactome:R-HSA-451311 "Activation of Ca-permeable Kainate receptors"
-xref: Reactome:R-HSA-622325 "Activation of highly sodium permeable nicotinic acetylcholine receptors"
+xref: Reactome:R-HSA-622325 "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors"
xref: Reactome:R-HSA-622326 "Activation of highly calcium permeable nicotinic acetylcholine receptors"
xref: Reactome:R-HSA-629595 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors"
is_a: GO:0005216 ! ion channel activity
@@ -115120,6 +115354,9 @@ namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]
synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW []
synonym: "solute:hydrogen antiporter activity" EXACT []
+xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics"
+xref: Reactome:R-HSA-5625574 "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+"
+xref: Reactome:R-HSA-597628 "SLC22A18 exchanges extracellular organic cations for cytosolic H+"
is_a: GO:0015078 ! proton transmembrane transporter activity
is_a: GO:0015298 ! solute:cation antiporter activity
@@ -115179,6 +115416,7 @@ synonym: "sialate transporter activity" BROAD []
synonym: "sialate/cation symporter activity" EXACT []
is_a: GO:0015136 ! sialic acid transmembrane transporter activity
is_a: GO:0015294 ! solute:cation symporter activity
+is_a: GO:0042887 ! amide transmembrane transporter activity
[Term]
id: GO:0015307
@@ -115188,9 +115426,6 @@ def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a m
comment: This term was obsoleted because it is not possible to state that every case of transmembrane transport for a specific chemical constitutes a drug transport.
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW []
synonym: "drug:hydrogen antiporter activity" EXACT []
-xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics"
-xref: Reactome:R-HSA-5625574 "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+"
-xref: Reactome:R-HSA-597628 "SLC22A18 exchanges extracellular organic cations for cytosolic H+"
is_obsolete: true
[Term]
@@ -115408,6 +115643,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to
synonym: "peptide:hydrogen symporter activity" EXACT []
xref: Reactome:R-HSA-427998 "Proton-coupled di- and tri-peptide cotransport"
xref: Reactome:R-HSA-428007 "Proton-coupled histidine and di-peptide cotransport"
+xref: RHEA:37047
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity
@@ -115535,7 +115771,7 @@ synonym: "ferric-enterobactin:proton symporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
is_a: GO:0015603 ! iron chelate transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
+is_a: GO:0042971 ! lactone transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
[Term]
@@ -115558,6 +115794,10 @@ xref: Reactome:R-HSA-561059 "OAT2 and OAT4 mediate transport of sulphate conjuga
xref: Reactome:R-HSA-879562 "SLCO2B1 has a narrow substrate specificity"
xref: Reactome:R-HSA-879584 "SLCO3A1 isoform 1 has abroad substrate specificity"
xref: Reactome:R-HSA-879594 "SLCO4C1 mediates the transport of digoxin"
+xref: Reactome:R-HSA-9661397 "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
+xref: Reactome:R-HSA-9661446 "BMG, BDG translocates from ER lumen to cytosol"
+xref: Reactome:R-HSA-9661723 "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
+xref: Reactome:R-HSA-9661799 "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0022853 ! active ion transmembrane transporter activity
@@ -115578,7 +115818,6 @@ id: GO:0015349
name: thyroid hormone transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai]
-xref: Reactome:R-HSA-5661195 "Defective SLCO1B1 does not transport T3,T4 from extracellular region to cytosol"
xref: Reactome:R-HSA-879575 "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol"
xref: Reactome:R-HSA-9631987 "SLCO1B1 transports T3,T4 from extracellular region to cytosol"
is_a: GO:0015291 ! secondary active transmembrane transporter activity
@@ -115807,7 +116046,6 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to
xref: Reactome:R-HSA-444120 "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5660840 "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol"
is_a: GO:0005295 ! neutral amino acid:sodium symporter activity
-is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0015187 ! glycine transmembrane transporter activity
[Term]
@@ -116104,6 +116342,7 @@ xref: EC:7.6.2.7
xref: MetaCyc:3.6.3.36-RXN
xref: RHEA:14614
is_a: GO:0005368 ! taurine transmembrane transporter activity
+is_a: GO:0008559 ! ATPase-coupled xenobiotic transmembrane transporter activity
is_a: GO:0033283 ! ATPase-coupled organic acid transmembrane transporter activity
is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity
@@ -116274,14 +116513,12 @@ synonym: "vitamin B12-transporting ATPase activity" BROAD []
xref: EC:7.6.2.8
xref: MetaCyc:3.6.3.33-RXN
xref: MetaCyc:ABC-5-RXN
-xref: Reactome:R-HSA-3000122 "CD320 transports extracellular TCII:Cbl to endosome"
xref: Reactome:R-HSA-3000238 "LMBRD1 transports lysosomal Cbl to cytosol"
xref: Reactome:R-HSA-3095901 "ABCC1 transports cytosolic Cbl to extracellular region"
xref: Reactome:R-HSA-3315437 "Defective LMBRD1 does not transport lysosomal Cbl to cytosol"
xref: RHEA:17873
xref: RHEA:32831
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
relationship: part_of GO:0015889 ! cobalamin transport
@@ -116298,6 +116535,7 @@ synonym: "oligopeptide-transporting ATPase activity" EXACT [EC:7.4.2.6]
xref: EC:7.4.2.6
xref: MetaCyc:3.6.3.23-RXN
xref: Reactome:R-HSA-5223317 "ABCB9 transports peptides from cytosol to lysosomal lumen"
+xref: RHEA:37271
is_a: GO:0015440 ! ATPase-coupled peptide transmembrane transporter activity
is_a: GO:0035673 ! oligopeptide transmembrane transporter activity
@@ -116383,6 +116621,7 @@ synonym: "polar-amino acid-transporting ATPase activity" EXACT []
synonym: "polar-amino-acid-transporting ATPase activity" EXACT [EC:7.4.2.1]
xref: EC:7.4.2.1
xref: MetaCyc:3.6.3.21-RXN
+xref: RHEA:14673
is_a: GO:0015424 ! ATPase-coupled amino acid transmembrane transporter activity
[Term]
@@ -116444,6 +116683,7 @@ synonym: "glutathione S-conjugate-transporting ATPase activity" RELATED [EC:7.6.
synonym: "GS-X pump" EXACT []
synonym: "MRP1/GS-X pump" EXACT []
xref: EC:7.6.2.3
+xref: RHEA:19121
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
created_by: mah
@@ -116563,8 +116803,12 @@ synonym: "protoheme IX ABC transporter activity" RELATED []
xref: EC:7.6.2.5
xref: MetaCyc:3.6.3.41-RXN
xref: MetaCyc:TRANS-RXN0-162
+xref: Reactome:R-HSA-1369065 "ABCB6 transports porphyrin from cytosol to mitchondrial matrix"
+xref: Reactome:R-HSA-382560 "ABC7, mABC1 and mABC2 mediate heme transport"
+xref: Reactome:R-HSA-5683355 "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix"
+xref: Reactome:R-HSA-917979 "ABCG2 tetramer transports heme from cytosol to extracellular region"
xref: RHEA:19261
-is_a: GO:0015232 ! heme transporter activity
+is_a: GO:0015232 ! heme transmembrane transporter activity
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
relationship: part_of GO:0035351 ! heme transmembrane transport
@@ -116579,6 +116823,7 @@ synonym: "peptide ABC transporter" NARROW []
synonym: "peptide-transporting ATPase activity" EXACT []
xref: EC:7.4.2.5
xref: MetaCyc:3.6.3.43-RXN
+xref: RHEA:14429
is_a: GO:0033220 ! ATPase-coupled amide-transporter activity
is_a: GO:1904680 ! peptide transmembrane transporter activity
relationship: part_of GO:0015833 ! peptide transport
@@ -117118,9 +117363,7 @@ name: pantothenate:sodium symporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1]
is_a: GO:0042887 ! amide transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
-is_a: GO:0090482 ! vitamin transmembrane transporter activity
is_a: GO:0140161 ! monocarboxylate:sodium symporter activity
relationship: part_of GO:0098719 ! sodium ion import across plasma membrane
@@ -117355,9 +117598,9 @@ id: GO:0015527
name: glycerol-phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3]
-is_a: GO:0015114 ! phosphate ion transmembrane transporter activity
-is_a: GO:0015168 ! glycerol transmembrane transporter activity
-is_a: GO:0140323 ! solute:anion antiporter activity
+is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity
+is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
+is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity
[Term]
id: GO:0015528
@@ -117463,6 +117706,7 @@ synonym: "sialic acid permease activity" RELATED []
synonym: "sialic acid:hydrogen symporter activity" EXACT []
xref: Reactome:R-HSA-428585 "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-5624239 "Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol"
+xref: RHEA:28987
is_a: GO:0015136 ! sialic acid transmembrane transporter activity
is_a: GO:0015295 ! solute:proton symporter activity
@@ -117535,7 +117779,6 @@ def: "Enables the transfer of sulfathiazole from one side of a membrane to the o
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED []
synonym: "sulphathiazole transporter activity" EXACT []
is_a: GO:0042887 ! amide transmembrane transporter activity
-is_a: GO:0042910 ! xenobiotic transmembrane transporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:1902599 ! sulfathiazole transmembrane transport
@@ -118001,6 +118244,7 @@ namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in)." [EC:3.6.3.17, TC:3.A.1.-.-]
synonym: "D-ribose porter activity" BROAD []
xref: MetaCyc:ABC-28-RXN
+xref: RHEA:29903
is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity
is_a: GO:0015591 ! D-ribose transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity
@@ -118012,6 +118256,7 @@ namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in)." [EC:3.6.3.17, TC:3.A.1.-.-]
synonym: "L-arabinose porter activity" EXACT []
xref: MetaCyc:ABC-2-RXN
+xref: RHEA:30007
is_a: GO:0015147 ! L-arabinose transmembrane transporter activity
is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity
@@ -118113,10 +118358,11 @@ synonym: "ferric-enterobactin ABC transporter" NARROW []
synonym: "ferric-enterobactin porter activity" BROAD []
synonym: "ferric-enterobactin-transporting ATPase activity" EXACT []
xref: MetaCyc:ABC-10-RXN
+xref: RHEA:58492
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015623 ! ATPase-coupled iron-chelate transporter activity
is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
+is_a: GO:0042971 ! lactone transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
[Term]
@@ -118423,6 +118669,7 @@ synonym: "branched-chain aliphatic amino acid transmembrane transporter activity
synonym: "branched-chain aliphatic amino acid transporter activity" EXACT []
synonym: "leucine/valine/isoleucine permease activity" RELATED []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
+xref: Reactome:R-HSA-9672770 "SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix"
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0015803 ! branched-chain amino acid transport
@@ -118466,7 +118713,6 @@ def: "Enables the directed movement of nicotinamide mononucleotide into, out of
synonym: "nicotinamide mononucleotide permease activity" RELATED []
synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT []
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity
relationship: part_of GO:0035353 ! nicotinamide mononucleotide transmembrane transport
@@ -118501,6 +118747,7 @@ synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" E
synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" EXACT [EC:2.1.1.113]
xref: EC:2.1.1.113
xref: MetaCyc:2.1.1.113-RXN
+xref: RHEA:16857
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity
relationship: part_of GO:0090124 ! N-4 methylation of cytosine
@@ -118530,7 +118777,6 @@ name: carbon dioxide transport
namespace: biological_process
def: "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015669 ! gas transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0019755 ! one-carbon compound transport
[Term]
@@ -118539,7 +118785,6 @@ name: oxygen transport
namespace: biological_process
def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015669 ! gas transport
-is_a: GO:0015893 ! drug transport
[Term]
id: GO:0015672
@@ -118901,7 +119146,6 @@ namespace: biological_process
def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "allantoin transmembrane transport" EXACT [GOC:mah]
synonym: "allantoin/allantoate transport" BROAD []
-is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport
is_a: GO:0071702 ! organic substance transport
@@ -118922,7 +119166,7 @@ name: canalicular bile acid transport
namespace: biological_process
def: "Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph]
is_a: GO:0015721 ! bile acid and bile salt transport
-is_a: GO:0046717 ! acid secretion
+is_a: GO:0046903 ! secretion
[Term]
id: GO:0015723
@@ -118938,7 +119182,6 @@ name: formate transport
namespace: biological_process
def: "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport
-is_a: GO:0015893 ! drug transport
[Term]
id: GO:0015726
@@ -118977,7 +119220,6 @@ name: propanoate transport
namespace: biological_process
def: "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "propionate transport" EXACT []
-is_a: GO:0015893 ! drug transport
is_a: GO:0015912 ! short-chain fatty acid transport
[Term]
@@ -119093,7 +119335,6 @@ name: succinate transport
namespace: biological_process
def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015740 ! C4-dicarboxylate transport
-is_a: GO:0015893 ! drug transport
[Term]
id: GO:0015745
@@ -119549,8 +119790,6 @@ def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionin
synonym: "S-adenosyl methionine transport" EXACT []
synonym: "S-adenosylmethionine transport" EXACT []
synonym: "SAM transport" EXACT []
-is_a: GO:0015893 ! drug transport
-is_a: GO:0051182 ! coenzyme transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0072348 ! sulfur compound transport
@@ -119616,7 +119855,6 @@ comment: See also the biological process term 'neurotransmitter transport ; GO:0
synonym: "4-aminobutanoate transport" EXACT []
synonym: "4-aminobutyrate transport" EXACT []
synonym: "GABA transport" EXACT []
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0006865 ! amino acid transport
is_a: GO:0015718 ! monocarboxylic acid transport
@@ -119629,8 +119867,6 @@ def: "The directed movement of L-glutamate across a membrane." [PMID:21307582]
synonym: "L-glutamate transport" BROAD []
synonym: "mitochondrial aspartate/glutamate transport" RELATED []
is_a: GO:0006835 ! dicarboxylic acid transport
-is_a: GO:0006836 ! neurotransmitter transport
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
@@ -119649,10 +119885,8 @@ name: glycine transport
namespace: biological_process
def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006812 ! cation transport
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0015807 ! L-amino acid transport
-is_a: GO:0015893 ! drug transport
[Term]
id: GO:0015817
@@ -119997,7 +120231,6 @@ name: uracil transport
namespace: biological_process
def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015855 ! pyrimidine nucleobase transport
-is_a: GO:0015893 ! drug transport
[Term]
id: GO:0015858
@@ -120080,7 +120313,6 @@ namespace: biological_process
def: "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0051503 ! adenine nucleotide transport
[Term]
@@ -120106,9 +120338,7 @@ id: GO:0015870
name: acetylcholine transport
namespace: biological_process
def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0015695 ! organic cation transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901374 ! acetate ester transport
@@ -120117,7 +120347,6 @@ id: GO:0015871
name: choline transport
namespace: biological_process
def: "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0015695 ! organic cation transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -120127,7 +120356,6 @@ name: dopamine transport
namespace: biological_process
def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
is_a: GO:0006812 ! cation transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0051937 ! catecholamine transport
[Term]
@@ -120148,7 +120376,6 @@ comment: This term was made obsolete because it was replaced by more specific te
synonym: "vitamin or cofactor transport" EXACT []
is_obsolete: true
consider: GO:0051180
-consider: GO:0051181
[Term]
id: GO:0015876
@@ -120156,14 +120383,12 @@ name: acetyl-CoA transport
namespace: biological_process
def: "The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai]
is_a: GO:0015916 ! fatty-acyl-CoA transport
-is_a: GO:0051182 ! coenzyme transport
[Term]
id: GO:0015877
name: biopterin transport
namespace: biological_process
def: "The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai]
-is_a: GO:0051182 ! coenzyme transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -120175,10 +120400,8 @@ def: "The directed movement of biotin into, out of or within a cell, or between
synonym: "vitamin B7 transport" EXACT []
synonym: "vitamin H transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport
is_a: GO:0051180 ! vitamin transport
-is_a: GO:0051182 ! coenzyme transport
is_a: GO:0072348 ! sulfur compound transport
[Term]
@@ -120196,7 +120419,6 @@ namespace: biological_process
def: "The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
-is_a: GO:0051182 ! coenzyme transport
is_a: GO:0051503 ! adenine nucleotide transport
[Term]
@@ -120206,7 +120428,6 @@ namespace: biological_process
alt_id: GO:1902598
def: "The directed movement of creatine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "creatine transport" BROAD []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
@@ -120223,7 +120444,6 @@ synonym: "L-ascorbic acid transport" RELATED []
synonym: "vitamin C transport" EXACT []
is_a: GO:0015749 ! monosaccharide transmembrane transport
is_a: GO:0035461 ! vitamin transmembrane transport
-is_a: GO:0051182 ! coenzyme transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
[Term]
@@ -120235,7 +120455,6 @@ synonym: "flavin adenine dinucleotide transport" EXACT []
synonym: "flavin-adenine dinucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0015711 ! organic anion transport
-is_a: GO:0051182 ! coenzyme transport
[Term]
id: GO:0015884
@@ -120246,10 +120465,8 @@ synonym: "folate transport" EXACT []
synonym: "vitamin B9 transport" EXACT []
synonym: "vitamin M transport" EXACT []
is_a: GO:0006835 ! dicarboxylic acid transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport
is_a: GO:0051180 ! vitamin transport
-is_a: GO:0051181 ! cofactor transport
is_a: GO:0072337 ! modified amino acid transport
[Term]
@@ -120259,7 +120476,6 @@ namespace: biological_process
def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0042886 ! amide transport
-is_a: GO:0051181 ! cofactor transport
is_a: GO:0072337 ! modified amino acid transport
[Term]
@@ -120268,7 +120484,6 @@ name: heme transport
namespace: biological_process
def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "haem transport" EXACT []
-is_a: GO:0051181 ! cofactor transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901678 ! iron coordination entity transport
@@ -120285,7 +120500,6 @@ synonym: "vitamin B5 transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0042886 ! amide transport
-is_a: GO:0051182 ! coenzyme transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
@@ -120296,7 +120510,6 @@ namespace: biological_process
def: "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai]
synonym: "thiamin transport" EXACT []
synonym: "vitamin B1 transport" EXACT []
-is_a: GO:0015893 ! drug transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -120308,9 +120521,7 @@ name: cobalamin transport
namespace: biological_process
def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "vitamin B12 transport" EXACT []
-is_a: GO:0015893 ! drug transport
is_a: GO:0051180 ! vitamin transport
-is_a: GO:0051181 ! cofactor transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -120321,7 +120532,6 @@ namespace: biological_process
def: "The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [ISBN:0721662544]
synonym: "nicotinamide ribonucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
-is_a: GO:0051181 ! cofactor transport
is_a: GO:1901264 ! carbohydrate derivative transport
[Term]
@@ -120354,7 +120564,6 @@ def: "The directed movement of acriflavine into, out of or within a cell, or bet
synonym: "acriflavin transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006821 ! chloride transport
is_a: GO:0015695 ! organic cation transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0042908 ! xenobiotic transport
[Term]
@@ -120370,7 +120579,6 @@ name: nalidixic acid transport
namespace: biological_process
def: "The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221]
is_a: GO:0015718 ! monocarboxylic acid transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -120404,7 +120612,6 @@ id: GO:0015900
name: benomyl transport
namespace: biological_process
def: "The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [GOC:curators]
-is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport
is_a: GO:0042908 ! xenobiotic transport
is_a: GO:0071702 ! organic substance transport
@@ -120415,7 +120622,6 @@ name: cycloheximide transport
namespace: biological_process
def: "The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732]
is_a: GO:0015850 ! organic hydroxy compound transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport
[Term]
@@ -120434,7 +120640,6 @@ name: fluconazole transport
namespace: biological_process
def: "The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators]
is_a: GO:0015850 ! organic hydroxy compound transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0071705 ! nitrogen compound transport
[Term]
@@ -120444,7 +120649,6 @@ namespace: biological_process
def: "The directed movement of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:curators]
synonym: "tetracyclin transport" BROAD []
synonym: "tetracycline transport" BROAD []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0098656 ! anion transmembrane transport
@@ -120455,7 +120659,7 @@ name: bicyclomycin transmembrane transport
namespace: biological_process
def: "The directed movement of bicyclomycin across a lipid bilayer, from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [PMID:20067529]
synonym: "bicyclomycin transport" BROAD []
-is_a: GO:0006855 ! drug transmembrane transport
+is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -120625,6 +120829,7 @@ name: trehalase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai]
xref: MetaCyc:TREHALA-RXN
+xref: RHEA:32675
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -120704,7 +120909,6 @@ alt_id: GO:0006763
def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
synonym: "CoA metabolism" EXACT []
synonym: "coenzyme A metabolism" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process
@@ -120723,7 +120927,6 @@ synonym: "coenzyme A synthesis" EXACT []
xref: MetaCyc:COA-PWY
xref: MetaCyc:PANTOSYN-PWY
xref: MetaCyc:PWY-4221
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0015936 ! coenzyme A metabolic process
is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process
@@ -120739,7 +120942,6 @@ synonym: "CoA catabolism" EXACT []
synonym: "coenzyme A breakdown" EXACT []
synonym: "coenzyme A catabolism" EXACT []
synonym: "coenzyme A degradation" EXACT []
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0015936 ! coenzyme A metabolic process
is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
@@ -120755,7 +120957,6 @@ synonym: "pantothenate metabolism" EXACT []
synonym: "vitamin B5 metabolic process" EXACT []
synonym: "vitamin B5 metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
@@ -120788,7 +120989,6 @@ xref: MetaCyc:PANTO-PWY
xref: MetaCyc:PANTOSYN-PWY
xref: MetaCyc:PWY-3961
xref: MetaCyc:PWY-4221
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0015939 ! pantothenate metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
@@ -120805,7 +121005,6 @@ synonym: "pantothenate catabolism" EXACT []
synonym: "pantothenate degradation" EXACT []
synonym: "vitamin B5 catabolic process" EXACT []
synonym: "vitamin B5 catabolism" EXACT []
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0015939 ! pantothenate metabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
@@ -120817,7 +121016,6 @@ name: formate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732]
synonym: "formate metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
[Term]
@@ -120832,7 +121030,6 @@ synonym: "formate synthesis" EXACT []
synonym: "formic acid biosynthesis" EXACT []
synonym: "formic acid biosynthetic process" EXACT []
is_a: GO:0015942 ! formate metabolic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
[Term]
@@ -121371,7 +121568,7 @@ is_obsolete: true
id: GO:0016002
name: sulfite reductase activity
namespace: molecular_function
-def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [RHEA:10547]
+def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [GOC:curators]
synonym: "assimilatory sulfite reductase activity" EXACT []
synonym: "assimilatory-type sulfite reductase activity" EXACT []
synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT []
@@ -121379,7 +121576,6 @@ synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT []
synonym: "siroheme sulfite reductase activity" NARROW [MetaCyc:SULFITE-REDUCTASE-RXN]
synonym: "sulphite reductase activity" EXACT []
xref: MetaCyc:SULFITE-REDUCTASE-RXN
-xref: RHEA:10547
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors
[Term]
@@ -121549,7 +121745,6 @@ synonym: "CDP-diacylglycerol anabolism" EXACT []
synonym: "CDP-diacylglycerol biosynthesis" EXACT []
synonym: "CDP-diacylglycerol formation" EXACT []
synonym: "CDP-diacylglycerol synthesis" EXACT []
-is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0046341 ! CDP-diacylglycerol metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process
@@ -121719,6 +121914,7 @@ synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" EXACT [EC:1.4.
xref: EC:1.4.7.1
xref: MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN
xref: MetaCyc:PWY-4341
+xref: RHEA:12128
is_a: GO:0015930 ! glutamate synthase activity
is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor
@@ -123072,6 +123268,7 @@ synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activit
synonym: "vanadium-iron nitrogenase activity" NARROW []
xref: EC:1.18.6.1
xref: MetaCyc:NITROGENASE-RXN
+xref: RHEA:21448
xref: UM-BBD_enzymeID:e0395
is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor
@@ -123128,7 +123325,6 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl]
is_a: GO:0043168 ! anion binding
is_a: GO:0046906 ! tetrapyrrole binding
-is_a: GO:0048037 ! cofactor binding
property_value: RO:0002161 NCBITaxon:33208
[Term]
@@ -123216,6 +123412,7 @@ xref: Reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from ox
xref: Reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen"
xref: Reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen"
xref: Reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-"
+xref: Reactome:R-HSA-9673797 "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen"
is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
[Term]
@@ -123446,7 +123643,7 @@ synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1
xref: EC:2.1.1.6
xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-175983 "COMT transfer CH3 from AdoMet to 3,4DHBNZ"
-xref: Reactome:R-HSA-8955010 "LRTOMT transfers methyl group from AdoMet to DA, forming 3MT"
+xref: Reactome:R-HSA-8955010 "LRTOMT transfers Met to DA, forming 3MT"
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
property_value: RO:0002161 NCBITaxon:4890
@@ -123488,7 +123685,6 @@ id: GO:0016208
name: AMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators]
-is_a: GO:0008144 ! drug binding
is_a: GO:0032559 ! adenyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043169 ! cation binding
@@ -123651,11 +123847,11 @@ name: iron-sulfur cluster assembly
namespace: biological_process
def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]
subset: goslim_metagenomics
+subset: goslim_pombe
synonym: "iron-sulfur cluster biosynthesis" RELATED []
synonym: "iron-sulphur cluster assembly" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0031163 ! metallo-sulfur cluster assembly
-is_a: GO:0051188 ! cofactor biosynthetic process
[Term]
id: GO:0016227
@@ -123671,8 +123867,6 @@ synonym: "transfer RNA sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "transfer RNA thiolase activity" EXACT [EC:2.8.1.4]
synonym: "tRNA sulfurtransferase activity" EXACT []
synonym: "tRNA sulphurtransferase activity" EXACT []
-xref: EC:2.8.1.4
-xref: MetaCyc:TRNA-S-TRANSFERASE-RXN
is_obsolete: true
replaced_by: GO:0034227
consider: GO:0016783
@@ -123981,6 +124175,7 @@ synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosa
synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT []
xref: EC:2.4.1.94
xref: MetaCyc:2.4.1.94-RXN
+xref: RHEA:16533
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -123997,6 +124192,7 @@ xref: EC:2.4.1.122
xref: MetaCyc:2.4.1.122-RXN
xref: Reactome:R-HSA-1964505 "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)"
xref: Reactome:R-HSA-6785524 "Defective C1GALT1C1 does not bind C1GALT1"
+xref: RHEA:15621
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein
@@ -124112,6 +124308,7 @@ synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferase
synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124]
xref: EC:2.1.1.124
xref: MetaCyc:2.1.1.124-RXN
+xref: RHEA:21872
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
[Term]
@@ -124145,7 +124342,6 @@ name: protein-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]
xref: Reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27"
-xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3"
xref: Reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex"
xref: Reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB"
xref: Reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A"
@@ -124277,6 +124473,7 @@ synonym: "tetradecanoyl-ACP hydrolase activity" EXACT []
xref: EC:3.1.2.14
xref: KEGG_REACTION:R08159
xref: MetaCyc:RXN-10727
+xref: RHEA:30123
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity
[Term]
@@ -124289,6 +124486,7 @@ synonym: "palmitoyl-ACP hydrolase activity" EXACT []
xref: EC:3.1.2.14
xref: KEGG_REACTION:R08162
xref: MetaCyc:RXN-9549
+xref: RHEA:41932
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity
[Term]
@@ -124307,6 +124505,7 @@ synonym: "S-acyl fatty acid synthase thioesterase activity" EXACT [EC:3.1.2.14]
xref: EC:3.1.2.14
xref: MetaCyc:RXN-7902
xref: Reactome:R-HSA-5655955 "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer"
+xref: RHEA:30131
is_a: GO:0004312 ! fatty acid synthase activity
is_a: GO:0016790 ! thiolester hydrolase activity
@@ -124512,6 +124711,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate." [GOC:hb]
xref: Reactome:R-HSA-6809561 "I(1,3)P2 is dephosphorylated into I1P by MTMR7"
xref: Reactome:R-HSA-6809565 "I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9"
+xref: RHEA:57840
is_a: GO:0052745 ! inositol phosphate phosphatase activity
[Term]
@@ -124968,6 +125168,7 @@ def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristano
xref: EC:1.3.3
xref: Reactome:R-HSA-389889 "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA"
xref: Reactome:R-HSA-389891 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)"
+xref: RHEA:40459
is_a: GO:0003997 ! acyl-CoA oxidase activity
[Term]
@@ -124982,6 +125183,7 @@ synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.
xref: EC:3.5.3.18
xref: MetaCyc:DIMETHYLARGININASE-RXN
xref: Reactome:R-HSA-5693373 "DDAH1,2 hydrolyses ADMA to DMA and L-Cit"
+xref: RHEA:17305
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
[Term]
@@ -125014,7 +125216,7 @@ def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + s
xref: Reactome:R-HSA-159443 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate"
xref: Reactome:R-HSA-159567 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate"
xref: Reactome:R-HSA-177157 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate"
-xref: Reactome:R-HSA-6798345 "GCAT:PXLP dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA"
+xref: Reactome:R-HSA-6798345 "PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA"
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds
[Term]
@@ -125163,6 +125365,7 @@ synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransfe
synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.62]
xref: EC:2.1.1.62
xref: MetaCyc:2.1.1.62-RXN
+xref: RHEA:22744
is_a: GO:0008174 ! mRNA methyltransferase activity
[Term]
@@ -125231,6 +125434,7 @@ synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity
synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.55]
xref: EC:2.1.1.55
xref: MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN
+xref: RHEA:16785
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity
@@ -125242,6 +125446,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-met
synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.25]
xref: EC:2.5.1.25
xref: MetaCyc:2.5.1.25-RXN
+xref: RHEA:12300
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -125311,6 +125516,7 @@ def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(
synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.110]
xref: EC:2.4.1.110
xref: MetaCyc:2.4.1.110-RXN
+xref: RHEA:12885
is_a: GO:0000030 ! mannosyltransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -125325,6 +125531,7 @@ synonym: "PTGS" EXACT []
synonym: "quelling" EXACT []
xref: Wikipedia:Post_transcriptional_gene_silencing
is_a: GO:0010608 ! posttranscriptional regulation of gene expression
+is_a: GO:0016458 ! gene silencing
is_a: GO:0040029 ! regulation of gene expression, epigenetic
[Term]
@@ -125466,6 +125673,7 @@ name: pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators]
xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP"
+xref: RHEA:51724
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
[Term]
@@ -125713,7 +125921,6 @@ def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol
synonym: "farnesol metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016093 ! polyprenol metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
[Term]
@@ -125727,7 +125934,6 @@ synonym: "farnesol degradation" EXACT []
is_a: GO:0016095 ! polyprenol catabolic process
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0016487 ! farnesol metabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
[Term]
@@ -125772,6 +125978,7 @@ xref: Reactome:R-HSA-9025007 "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA
xref: Reactome:R-HSA-9026001 "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA"
xref: Reactome:R-HSA-9026917 "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA"
xref: Reactome:R-HSA-9027033 "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA"
+xref: RHEA:27453
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0055114 ! oxidation-reduction process
@@ -125950,6 +126157,7 @@ synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" EXACT [
xref: EC:1.1.1.211
xref: MetaCyc:1.1.1.211-RXN
xref: Reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA"
+xref: RHEA:52656
is_a: GO:0003857 ! 3-hydroxyacyl-CoA dehydrogenase activity
[Term]
@@ -125970,8 +126178,6 @@ def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Tr
comment: This term was made obsolete because it represents a gene product.
synonym: "ECE-1 activity" EXACT [EC:3.4.24.71]
synonym: "endothelin-converting enzyme 1 activity" EXACT []
-xref: EC:3.4.24.71
-xref: MetaCyc:3.4.24.71-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -126119,6 +126325,7 @@ namespace: molecular_function
def: "Directly binding to and delivering metal ions to a target protein." [PMID:11739376]
subset: goslim_pir
is_a: GO:0140104 ! molecular carrier activity
+relationship: has_part GO:0046872 ! metal ion binding
[Term]
id: GO:0016531
@@ -126682,9 +126889,7 @@ def: "Interacting selectively and non-covalently with glycine, aminoethanoic aci
synonym: "aminoacetic acid binding" EXACT []
synonym: "aminoethanoic acid binding" EXACT []
synonym: "Gly binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0016597 ! amino acid binding
-is_a: GO:0042165 ! neurotransmitter binding
is_a: GO:0043169 ! cation binding
[Term]
@@ -126702,6 +126907,7 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with thienylcyclohexylpiperidine." [GOC:jl]
synonym: "TCP binding" BROAD []
is_a: GO:0008144 ! drug binding
+is_a: GO:0043169 ! cation binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding
@@ -126763,6 +126969,7 @@ synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5]
synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.5]
xref: EC:2.3.2.5
xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN
+xref: RHEA:23652
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
[Term]
@@ -126898,6 +127105,7 @@ synonym: "NADH:hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81]
xref: EC:1.1.1.81
xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN
xref: MetaCyc:RXN0-300
+xref: RHEA:18657
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -126979,6 +127187,7 @@ def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH grou
synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW []
xref: EC:1.3
xref: Reactome:R-HSA-2995334 "COX15 transforms heme O to heme A"
+xref: Reactome:R-HSA-9661710 "An unknown oxidase oxidises D-UBGN to UBN"
is_a: GO:0016491 ! oxidoreductase activity
[Term]
@@ -126989,6 +127198,8 @@ def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH grou
xref: EC:1.3.1
xref: Reactome:R-HSA-4419979 "SRD5A3 reduces pPNOL to DCHOL"
xref: Reactome:R-HSA-4755572 "Defective SRD5A3 does not reduce pPNOL to DCHOL"
+xref: Reactome:R-HSA-9661726 "An unknown reductase reduces D-UBGN to STBN"
+xref: Reactome:R-HSA-9661745 "An unknown BILR reduces BIL to D-UBGN"
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors
[Term]
@@ -127068,6 +127279,7 @@ synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" E
synonym: "L-galactonolactone dehydrogenase activity" EXACT [EC:1.3.2.3]
xref: EC:1.3.2.3
xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN
+xref: RHEA:32367
is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor
[Term]
@@ -127542,6 +127754,7 @@ synonym: "L-ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11]
synonym: "L-ascorbic acid-specific peroxidase activity" EXACT [EC:1.11.1.11]
xref: EC:1.11.1.11
xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN
+xref: RHEA:22996
is_a: GO:0004601 ! peroxidase activity
[Term]
@@ -127807,7 +128020,7 @@ id: GO:0016711
name: flavonoid 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.14.82]
-synonym: "flavonoid 3'-hydroxylase activity" EXACT [b]
+synonym: "flavonoid 3'-hydroxylase activity" EXACT [EC:1.14.14.82]
synonym: "flavonoid 3-hydroxylase" RELATED []
synonym: "flavonoid 3-monooxygenase" RELATED []
synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.14.82]
@@ -128107,7 +128320,6 @@ xref: EC:2
xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2"
xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1"
xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK"
-xref: Reactome:R-HSA-6787403 "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA"
xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248"
is_a: GO:0003824 ! catalytic activity
@@ -128255,6 +128467,7 @@ synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltrans
synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15]
xref: EC:2.3.2.15
xref: MetaCyc:2.3.2.15-RXN
+xref: RHEA:17917
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
[Term]
@@ -128317,6 +128530,7 @@ synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity"
synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12]
xref: EC:2.4.1.12
xref: MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN
+xref: RHEA:19929
is_a: GO:0016759 ! cellulose synthase activity
is_a: GO:0035251 ! UDP-glucosyltransferase activity
@@ -128334,6 +128548,7 @@ synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activit
synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29]
xref: EC:2.4.1.29
xref: MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN
+xref: RHEA:17797
is_a: GO:0016759 ! cellulose synthase activity
[Term]
@@ -128632,7 +128847,7 @@ name: phosphatase activity
namespace: molecular_function
alt_id: GO:0003869
alt_id: GO:0016302
-def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators, GOC:pg]
+def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:curators, GOC:pg]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
@@ -128641,21 +128856,21 @@ subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
synonym: "4-nitrophenylphosphatase activity" NARROW []
-synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41]
-synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41]
-synonym: "K-pNPPase activity" NARROW [EC:3.1.3.41]
-synonym: "nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41]
-synonym: "NPPase activity" NARROW [EC:3.1.3.41]
-synonym: "p-nitrophenylphosphatase activity" NARROW [EC:3.1.3.41]
-synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41]
-synonym: "para-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41]
+synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW []
+synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW []
+synonym: "K-pNPPase activity" NARROW []
+synonym: "nitrophenyl phosphatase activity" NARROW []
+synonym: "NPPase activity" NARROW []
+synonym: "p-nitrophenylphosphatase activity" NARROW []
+synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW []
+synonym: "para-nitrophenyl phosphatase activity" NARROW []
synonym: "phosphatase" RELATED []
synonym: "phosphoric monoester hydrolase activity" EXACT []
-synonym: "PNPPase activity" NARROW [EC:3.1.3.41]
+synonym: "PNPPase activity" NARROW []
xref: EC:3.1.3
xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN
xref: Reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL"
-xref: RHEA:21664
+xref: Reactome:R-HSA-9636457 "SapM dephosphorylates PI3P"
is_a: GO:0042578 ! phosphoric ester hydrolase activity
relationship: part_of GO:0016311 ! dephosphorylation
@@ -128666,6 +128881,7 @@ namespace: molecular_function
def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai]
xref: EC:3.1.5
xref: Reactome:R-HSA-8866601 "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate"
+xref: RHEA:46148
is_a: GO:0042578 ! phosphoric ester hydrolase activity
[Term]
@@ -128766,8 +128982,6 @@ synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5]
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5]
synonym: "proline iminopeptidase activity" EXACT []
synonym: "prolyl aminopeptidase activity" EXACT []
-xref: EC:3.4.11.5
-xref: MetaCyc:3.4.11.5-RXN
is_obsolete: true
replaced_by: GO:0004177
@@ -128777,10 +128991,14 @@ name: dipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a dipeptide." [PMID:19879002]
xref: EC:3.4.13
+xref: EC:3.4.13.18
+xref: EC:3.4.13.21
+xref: MetaCyc:3.4.13.18-RXN
+xref: MetaCyc:3.4.13.21-RXN
xref: Reactome:R-HSA-266012 "LTD4 is converted to LTE4 by DPEP1/2"
xref: Reactome:R-HSA-5433067 "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG"
xref: Reactome:R-HSA-5693783 "NAALADases hydrolyse NAAG"
-xref: Reactome:R-HSA-9026771 "DPEP hydroyses MCTR2 to MCTR3"
+xref: Reactome:R-HSA-9026771 "DPEP hydrolyses MCTR2 to MCTR3"
is_a: GO:0008238 ! exopeptidase activity
[Term]
@@ -128810,7 +129028,6 @@ namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "proprotein convertase activity" EXACT []
-xref: EC:3.4.21
is_obsolete: true
replaced_by: GO:0004252
@@ -128825,6 +129042,7 @@ subset: goslim_generic
synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW []
xref: EC:3.5
xref: Reactome:R-HSA-6803753 "NAAA hydrolyses NAEs to FAs and ethanolamine"
+xref: RHEA:45456
is_a: GO:0016787 ! hydrolase activity
[Term]
@@ -128833,6 +129051,8 @@ name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
xref: EC:3.5.1
+xref: Reactome:R-HSA-9673053 "PM20D1 transforms oleoyl-phe from oleate and phe"
+xref: Reactome:R-HSA-9673054 "PM20D1 hydrolyzes oleoyl-phe"
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
[Term]
@@ -128987,8 +129207,9 @@ subset: goslim_pir
subset: goslim_yeast
synonym: "other lyase activity" NARROW []
xref: EC:4
-xref: Reactome:R-HSA-5696408 "PHYKPL tetramer hydrolyses 5PHL"
+xref: Reactome:R-HSA-5696408 "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL"
xref: Reactome:R-HSA-6782895 "TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)"
+xref: RHEA:34091
is_a: GO:0003824 ! catalytic activity
[Term]
@@ -128999,17 +129220,18 @@ def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis o
synonym: "other carbon-carbon lyase activity" NARROW []
xref: EC:4.1
xref: Reactome:R-HSA-389611 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA"
+xref: RHEA:25355
is_a: GO:0016829 ! lyase activity
[Term]
id: GO:0016831
name: carboxy-lyase activity
namespace: molecular_function
-def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
+def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]
synonym: "decarboxylase activity" EXACT []
xref: EC:4.1.1
-xref: Reactome:R-HSA-6787757 "GADL1 decarboxylates acidic AAs"
-xref: Reactome:R-HSA-6814165 "GADL1 decarboxylates CSA to HTAU"
+xref: Reactome:R-HSA-6787757 "PXLP-K333-GADL1 decarboxylates acidic AAs"
+xref: Reactome:R-HSA-6814165 "PXLP-K333-GADL1 decarboxylates CSA to HTAU"
xref: Reactome:R-HSA-71223 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2"
is_a: GO:0016830 ! carbon-carbon lyase activity
@@ -129018,7 +129240,7 @@ id: GO:0016832
name: aldehyde-lyase activity
namespace: molecular_function
alt_id: GO:0016228
-def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/]
+def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators]
synonym: "aldolase activity" BROAD []
xref: EC:4.1.2
is_a: GO:0016830 ! carbon-carbon lyase activity
@@ -129322,6 +129544,7 @@ synonym: "intramolecular isomerase activity" EXACT []
synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW []
xref: EC:5.3
xref: Reactome:R-HSA-109998 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA"
+xref: RHEA:45752
is_a: GO:0016853 ! isomerase activity
[Term]
@@ -129439,7 +129662,7 @@ is_a: GO:0031559 ! oxidosqualene cyclase activity
id: GO:0016872
name: intramolecular lyase activity
namespace: molecular_function
-def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/]
+def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl]
xref: EC:5.5.1
is_a: GO:0016853 ! isomerase activity
@@ -129457,7 +129680,7 @@ consider: GO:0016853
id: GO:0016874
name: ligase activity
namespace: molecular_function
-def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
+def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6, GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_chembl
@@ -129470,6 +129693,7 @@ subset: goslim_yeast
synonym: "synthetase activity" EXACT [GOC:jh2]
xref: EC:6
is_a: GO:0003824 ! catalytic activity
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19380 xsd:anyURI
[Term]
id: GO:0016875
@@ -129616,6 +129840,7 @@ xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of
xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG"
xref: Reactome:R-HSA-917693 "ESCRT Disassembly"
xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP"
+xref: Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope"
xref: RHEA:13065
is_a: GO:0017111 ! nucleoside-triphosphatase activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19078 xsd:anyURI
@@ -129793,6 +130018,7 @@ synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin-heavy-chain kinase activity" EXACT [EC:2.7.11.7]
synonym: "STK6" RELATED [EC:2.7.11.7]
xref: EC:2.7.11.7
+xref: RHEA:11424
is_a: GO:0004683 ! calmodulin-dependent protein kinase activity
[Term]
@@ -129953,8 +130179,6 @@ synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61]
synonym: "nardilysin activity" EXACT []
synonym: "NRD convertase activity" EXACT [EC:3.4.24.61]
synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61]
-xref: EC:3.4.24.61
-xref: MetaCyc:3.4.24.61-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -129964,6 +130188,7 @@ name: pyroglutamyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah]
xref: EC:3.4.19
+is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0008242 ! omega peptidase activity
[Term]
@@ -130169,8 +130394,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin F activity" EXACT []
-xref: EC:3.4.22.41
-xref: MetaCyc:3.4.22.41-RXN
is_obsolete: true
replaced_by: GO:0004197
@@ -130221,6 +130444,7 @@ synonym: "P450nor" NARROW []
xref: EC:1.7.2.5
xref: KEGG_REACTION:R00294
xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN
+xref: RHEA:30211
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
[Term]
@@ -130457,6 +130681,7 @@ synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [
xref: EC:2.8.1.8
xref: MetaCyc:RXN0-949
xref: Reactome:R-HSA-6793591 "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH"
+xref: RHEA:16585
is_a: GO:0016783 ! sulfurtransferase activity
relationship: part_of GO:0009107 ! lipoate biosynthetic process
@@ -130792,8 +131017,6 @@ synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19]
-xref: EC:3.4.24.19
-xref: MetaCyc:3.4.24.19-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -130875,8 +131098,6 @@ synonym: "dipeptidyl-peptidase III activity" EXACT []
synonym: "DPP III activity" EXACT [EC:3.4.14.4]
synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4]
synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4]
-xref: EC:3.4.14.4
-xref: MetaCyc:3.4.14.4-RXN
is_obsolete: true
replaced_by: GO:0008239
@@ -130910,6 +131131,7 @@ synonym: "trihexosyl ceramide galactosidase activity" EXACT [EC:3.2.1.47]
synonym: "trihexosylceramide alpha-galactosidase activity" EXACT [EC:3.2.1.47]
xref: EC:3.2.1.47
xref: MetaCyc:3.2.1.47-RXN
+xref: RHEA:21112
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -130997,6 +131219,7 @@ xref: MetaCyc:RXN3DJ-11417
xref: Reactome:R-HSA-428273 "sphingosine +ATP => sphingosine 1-phosphate + ADP"
xref: Reactome:R-HSA-5218845 "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate"
xref: Reactome:R-HSA-9625814 "SPHK1 phosphorylates sphingosine in response to E2 stimulation"
+xref: RHEA:35847
is_a: GO:0016301 ! kinase activity
[Term]
@@ -131170,6 +131393,7 @@ synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-tra
xref: EC:2.4.2.28
xref: MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN
xref: Reactome:R-HSA-1237160 "MTA is cleaved and phosphorylated"
+xref: RHEA:11852
is_a: GO:0004731 ! purine-nucleoside phosphorylase activity
[Term]
@@ -131282,8 +131506,6 @@ synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14]
synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14]
synonym: "type III procollagen" RELATED [EC:3.4.24.14]
-xref: EC:3.4.24.14
-xref: MetaCyc:3.4.24.14-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -131379,6 +131601,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI]
synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT []
xref: Reactome:R-HSA-508040 "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]"
+xref: RHEA:33207
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -131404,7 +131627,7 @@ is_a: GO:0032991 ! protein-containing complex
id: GO:0017087
name: mitochondrial processing peptidase complex
namespace: cellular_component
-def: "A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [BRENDA:3.4.24.64, EC:3.4.24.64, GOC:mah]
+def: "A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [GOC:mah]
comment: Note that monomeric mitochondrial processing peptidases have been observed.
is_a: GO:0098798 ! mitochondrial protein complex
relationship: part_of GO:0005759 ! mitochondrial matrix
@@ -131420,8 +131643,6 @@ synonym: "X-Pro dipeptidyl-peptidase activity" EXACT []
synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11]
synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11]
synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT []
-xref: EC:3.4.14.11
-xref: MetaCyc:3.4.14.11-RXN
is_obsolete: true
replaced_by: GO:0008239
@@ -131478,7 +131699,7 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP protease activity" EXACT []
synonym: "sterol regulatory element-binding protein protease activity" EXACT []
is_obsolete: true
-replaced_by: GO:0070011
+replaced_by: GO:0008233
[Term]
id: GO:0017094
@@ -131536,6 +131757,7 @@ def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + red
synonym: "very long-chain-acyl-CoA dehydrogenase activity" EXACT []
xref: EC:1.3.99
xref: Reactome:R-HSA-548831 "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA"
+xref: RHEA:35351
is_a: GO:0004466 ! long-chain-acyl-CoA dehydrogenase activity
[Term]
@@ -131614,6 +131836,7 @@ namespace: molecular_function
def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]
synonym: "5' flap endonuclease activity" EXACT []
xref: Reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA"
+xref: Reactome:R-HSA-174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand"
xref: Reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand"
xref: Reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)"
xref: Reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ"
@@ -131656,6 +131879,7 @@ xref: Reactome:R-HSA-8851225 "NTPDase4 hydrolyzes nucleoside diphosphates"
xref: Reactome:R-HSA-8851356 "NTPDase5 hydrolyzes nucleoside diphosphates"
xref: Reactome:R-HSA-8851396 "NTPDase6 hydrolyzes nucleoside diphosphates"
xref: Reactome:R-HSA-8851550 "NTPDase8 hydrolyzes nucleoside diphosphates"
+xref: RHEA:36799
is_a: GO:0016462 ! pyrophosphatase activity
[Term]
@@ -131777,7 +132001,7 @@ is_a: GO:0016747 ! transferase activity, transferring acyl groups other than ami
id: GO:0017119
name: Golgi transport complex
namespace: cellular_component
-def: "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). In mammals the subunits are named COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]
+def: "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]
synonym: "COG complex" EXACT []
synonym: "conserved oligomeric Golgi complex" EXACT []
synonym: "Sec34/35 complex" NARROW []
@@ -131851,7 +132075,7 @@ id: GO:0017128
name: phospholipid scramblase activity
namespace: molecular_function
def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]
-comment: Nomenclature note. Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Some authors however use the name floppase to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909).
+comment: Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases).
is_a: GO:0005548 ! phospholipid transporter activity
is_a: GO:0140303 ! intramembrane lipid transporter activity
relationship: part_of GO:0017121 ! plasma membrane phospholipid scrambling
@@ -132082,6 +132306,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]
xref: MetaCyc:RXN0-1281
xref: Reactome:R-HSA-6782296 "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs"
+xref: RHEA:23624
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
relationship: part_of GO:0002943 ! tRNA dihydrouridine synthesis
@@ -132182,8 +132407,8 @@ id: GO:0017161
name: inositol-1,3,4-trisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai]
-xref: EC:3.1.3
xref: Reactome:R-HSA-1855180 "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol"
+xref: RHEA:43392
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity
[Term]
@@ -132228,8 +132453,6 @@ synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21]
synonym: "dipeptidase E activity" EXACT []
synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21]
synonym: "peptidase E activity" BROAD [EC:3.4.13.21]
-xref: EC:3.4.13.21
-xref: MetaCyc:3.4.13.21-RXN
is_obsolete: true
replaced_by: GO:0016805
@@ -132808,6 +133031,7 @@ xref: Reactome:R-HSA-5651657 "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methy
xref: RESID:AA0074
xref: RESID:AA0075
xref: RESID:AA0076
+xref: RHEA:10024
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0042054 ! histone methyltransferase activity
relationship: part_of GO:0034968 ! histone lysine methylation
@@ -132823,6 +133047,7 @@ synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity"
xref: EC:2.1.1.60
xref: MetaCyc:2.1.1.60-RXN
xref: Reactome:R-HSA-6786205 "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1"
+xref: RHEA:21556
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
[Term]
@@ -133159,15 +133384,17 @@ synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity"
synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" EXACT [EC:2.1.1.85]
xref: EC:2.1.1.85
xref: MetaCyc:2.1.1.85-RXN
+xref: RHEA:19369
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
id: GO:0018065
-name: protein-cofactor linkage
+name: obsolete protein-cofactor linkage
namespace: biological_process
-def: "The covalent attachment of a cofactor to a protein." [GOC:ai]
-is_a: GO:0006464 ! cellular protein modification process
+def: "OBSOLETE. The covalent attachment of a cofactor to a protein." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group protein modification processes that are not all chemically related by the fact that they may be used as a cofactor.
+is_obsolete: true
[Term]
id: GO:0018067
@@ -133990,7 +134217,6 @@ def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via
synonym: "dipyrromethane cofactor binding" RELATED [GOC:jsg]
synonym: "peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine" EXACT [GOC:jsg]
xref: RESID:AA0252
-is_a: GO:0018065 ! protein-cofactor linkage
is_a: GO:0018198 ! peptidyl-cysteine modification
[Term]
@@ -134280,7 +134506,6 @@ synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT []
xref: RESID:AA0283
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0018212 ! peptidyl-tyrosine modification
-is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
@@ -134743,7 +134968,7 @@ id: GO:0018246
name: protein-coenzyme A linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah]
-is_a: GO:0018065 ! protein-cofactor linkage
+is_a: GO:0006464 ! cellular protein modification process
[Term]
id: GO:0018247
@@ -135223,7 +135448,7 @@ id: GO:0018293
name: protein-FAD linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai]
-is_a: GO:0018065 ! protein-cofactor linkage
+is_a: GO:0006464 ! cellular protein modification process
[Term]
id: GO:0018294
@@ -135380,7 +135605,7 @@ id: GO:0018309
name: protein-FMN linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah]
-is_a: GO:0018065 ! protein-cofactor linkage
+is_a: GO:0006464 ! cellular protein modification process
[Term]
id: GO:0018310
@@ -135726,7 +135951,7 @@ id: GO:0018352
name: protein-pyridoxal-5-phosphate linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate." [GOC:mah]
-is_a: GO:0018065 ! protein-cofactor linkage
+is_a: GO:0006464 ! cellular protein modification process
[Term]
id: GO:0018353
@@ -135845,6 +136070,7 @@ def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5
synonym: "protein-serine racemase activity" EXACT [EC:5.1.1.16]
xref: EC:5.1.1.16
xref: MetaCyc:5.1.1.16-RXN
+xref: RHEA:10660
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives
[Term]
@@ -136428,6 +136654,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_reactionID:r0427]
xref: EC:1.1.1.327
xref: MetaCyc:R542-RXN
+xref: RHEA:32879
xref: UM-BBD_reactionID:r0427
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -136483,6 +136710,7 @@ synonym: "benzyl alcohol dehydrogenase activity" NARROW []
synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90]
xref: EC:1.1.1.90
xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN
+xref: RHEA:12076
xref: UM-BBD_enzymeID:e0019
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -136727,6 +136955,7 @@ synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylati
synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT []
xref: EC:1.2.1.18
xref: MetaCyc:1.2.1.18-RXN
+xref: RHEA:22988
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -136845,6 +137074,7 @@ def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic a
synonym: "aryl-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.9]
xref: EC:1.2.3.9
xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN
+xref: RHEA:18569
xref: UM-BBD_reactionID:r0145
is_a: GO:0004031 ! aldehyde oxidase activity
@@ -136891,6 +137121,7 @@ synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT []
synonym: "alpha-ketobutyrate synthase activity" EXACT []
synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT []
xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN
+xref: RHEA:32135
xref: UM-BBD_reactionID:r0358
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
@@ -136964,6 +137195,7 @@ name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308]
xref: MetaCyc:PHENPRODIOLDEHYDROG-RXN
+xref: RHEA:25062
xref: UM-BBD_enzymeID:e0308
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
@@ -136997,6 +137229,7 @@ name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_reactionID:r0553]
xref: MetaCyc:LINC-RXN
+xref: RHEA:15741
xref: UM-BBD_reactionID:r0553
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
@@ -137018,6 +137251,7 @@ synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide)
synonym: "cis-benzene glycol dehydrogenase activity" EXACT [EC:1.3.1.19]
xref: EC:1.3.1.19
xref: MetaCyc:1.3.1.19-RXN
+xref: RHEA:15457
xref: UM-BBD_enzymeID:e0060
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
@@ -137239,6 +137473,7 @@ synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatiz
xref: EC:1.3.7.8
xref: KEGG_REACTION:R02451
xref: MetaCyc:1.3.99.15-RXN
+xref: RHEA:30199
xref: UM-BBD_reactionID:r0190
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
@@ -137250,6 +137485,7 @@ def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-
synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.17]
xref: EC:1.3.99.17
xref: MetaCyc:1.3.99.17-RXN
+xref: RHEA:17749
xref: UM-BBD_reactionID:r0045
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors
@@ -137273,6 +137509,7 @@ synonym: "4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity" EXACT [EC:1.3
xref: EC:1.3.7.9
xref: KEGG_REACTION:R05316
xref: MetaCyc:OHBENZCOARED-RXN
+xref: RHEA:29603
xref: UM-BBD_reactionID:r0158
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
@@ -137473,6 +137710,7 @@ name: nitrobenzene nitroreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O." [MetaCyc:RXN-8815]
xref: MetaCyc:RXN-8815
+xref: RHEA:52884
xref: UM-BBD_enzymeID:e0245
is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor
@@ -137706,6 +137944,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_reactionID:r0395]
xref: EC:1.13.11
xref: MetaCyc:RXN-664
+xref: RHEA:42344
xref: UM-BBD_reactionID:r0395
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
@@ -137718,6 +137957,7 @@ synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT []
synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT []
xref: EC:1.13.11
xref: MetaCyc:RXN-666
+xref: RHEA:42568
xref: UM-BBD_reactionID:r0397
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
@@ -138059,6 +138299,7 @@ name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2." [UM-BBD_reactionID:r0274]
xref: MetaCyc:RXN-9863
+xref: RHEA:48984
xref: UM-BBD_reactionID:r0274
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
@@ -138124,6 +138365,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN]
xref: EC:1.14.12
xref: MetaCyc:R606-RXN
+xref: RHEA:42460
xref: UM-BBD_enzymeID:e0030
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor
@@ -138403,6 +138645,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone." [UM-BBD_reactionID:r0226]
xref: EC:1.14.13
xref: MetaCyc:RXN-8739
+xref: RHEA:34327
xref: UM-BBD_reactionID:r0226
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -138485,6 +138728,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621]
xref: EC:1.14.13
xref: MetaCyc:RXN-621
+xref: RHEA:49076
xref: UM-BBD_enzymeID:e0214
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -138523,6 +138767,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [UM-BBD_enzymeID:e0222]
xref: EC:1.14.13
xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN
+xref: RHEA:20349
xref: UM-BBD_enzymeID:e0222
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -138610,6 +138855,7 @@ def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- +
synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT []
xref: EC:1.14.13
xref: MetaCyc:TSMOS-RXN
+xref: RHEA:51024
xref: UM-BBD_reactionID:r0290
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -138873,6 +139119,7 @@ synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXA
synonym: "4-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.33]
xref: EC:1.14.13.33
xref: MetaCyc:1.14.13.33-RXN
+xref: RHEA:19473
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -138967,6 +139214,7 @@ synonym: "pentachlorophenol hydroxylase activity" EXACT []
synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" EXACT [EC:1.14.13.50]
xref: EC:1.14.13.50
xref: MetaCyc:PCP4MONO-RXN
+xref: RHEA:18685
xref: UM-BBD_enzymeID:e0148
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -139042,6 +139290,7 @@ synonym: "methylene hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "methylene monooxygenase activity" EXACT [EC:1.14.15.1]
xref: EC:1.14.15.1
xref: MetaCyc:R541-RXN
+xref: RHEA:13525
xref: UM-BBD_enzymeID:e0300
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
@@ -139077,6 +139326,7 @@ synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3]
synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3]
xref: EC:1.14.15.3
xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN
+xref: RHEA:19341
xref: UM-BBD_enzymeID:e0022
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
@@ -139162,6 +139412,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_reactionID:r0392]
xref: EC:1.17.99
xref: MetaCyc:RXN-661
+xref: RHEA:51604
xref: UM-BBD_reactionID:r0392
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups
@@ -139278,6 +139529,7 @@ synonym: "pyrogallol hydroxyltransferase activity" EXACT []
synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2]
xref: EC:1.97.1.2
xref: MetaCyc:1.97.1.2-RXN
+xref: RHEA:21000
xref: UM-BBD_reactionID:r0006
is_a: GO:0016491 ! oxidoreductase activity
@@ -139300,6 +139552,7 @@ synonym: "TMT" RELATED [EC:2.1.1.9]
xref: EC:2.1.1.9
xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN
xref: Reactome:R-HSA-175976 "TMT transfers CH3 from AdoMet to BME"
+xref: RHEA:18277
xref: UM-BBD_enzymeID:e0146
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
@@ -139729,6 +139982,7 @@ name: ammeline aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731]
xref: MetaCyc:RXN-8016
+xref: RHEA:26201
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
[Term]
@@ -139800,6 +140054,7 @@ def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7]
synonym: "aliphatic nitrile aminohydrolase activity" EXACT [EC:3.5.5.7]
xref: EC:3.5.5.7
xref: MetaCyc:3.5.5.7-RXN
+xref: RHEA:46188
xref: UM-BBD_reactionID:r0622
is_a: GO:0000257 ! nitrilase activity
@@ -139836,6 +140091,7 @@ name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_reactionID:r0263]
xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN
+xref: RHEA:59220
xref: UM-BBD_reactionID:r0263
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
@@ -140029,6 +140285,7 @@ synonym: "L-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2]
synonym: "L-DEX activity" EXACT [EC:3.8.1.2]
xref: EC:3.8.1.2
xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN
+xref: RHEA:11192
xref: UM-BBD_reactionID:r0090
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds
@@ -140041,6 +140298,7 @@ synonym: "haloacetate halidohydrolase activity" EXACT [EC:3.8.1.3]
synonym: "monohaloacetate dehalogenase activity" EXACT [EC:3.8.1.3]
xref: EC:3.8.1.3
xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN
+xref: RHEA:11044
xref: UM-BBD_enzymeID:e0006
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds
@@ -140361,6 +140619,7 @@ synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT []
synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT []
synonym: "HpaH" RELATED []
xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN
+xref: RHEA:42072
xref: UM-BBD_reactionID:r0369
is_a: GO:0016836 ! hydro-lyase activity
@@ -140458,6 +140717,7 @@ synonym: "HAB mutase activity" EXACT [EC:5.4.4.1]
synonym: "hydroxylaminobenzene hydroxymutase activity" EXACT [EC:5.4.4.1]
synonym: "hydroxylaminobenzene mutase activity" EXACT [EC:5.4.4.1]
xref: MetaCyc:5.4.4.1-RXN
+xref: RHEA:19245
xref: UM-BBD_reactionID:r0304
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups
@@ -140593,6 +140853,7 @@ synonym: "organomercurial lyase activity" EXACT [EC:4.99.1.2]
synonym: "organomercury lyase activity" EXACT [EC:4.99.1.2]
xref: EC:4.99.1.2
xref: MetaCyc:ALKYLMERCURY-LYASE-RXN
+xref: RHEA:18777
xref: UM-BBD_enzymeID:e0055
is_a: GO:0016829 ! lyase activity
@@ -140772,6 +141033,7 @@ name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_reactionID:r0429]
xref: EC:6.2.1.38
+xref: RHEA:33419
xref: UM-BBD_reactionID:r0429
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity
@@ -140800,7 +141062,7 @@ is_a: GO:0016878 ! acid-thiol ligase activity
id: GO:0018858
name: benzoate-CoA ligase activity
namespace: molecular_function
-def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate + H(+)." [EC:6.2.1.25, RHEA:10132]
+def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate." [EC:6.2.1.25, RHEA:10132]
synonym: "benzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.25]
synonym: "benzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.25]
synonym: "benzoyl CoA synthetase (AMP forming)" EXACT [EC:6.2.1.25]
@@ -140903,7 +141165,6 @@ def: "The chemical reactions and pathways involving acrylonitrile, a colorless,
synonym: "acrylonitrile metabolism" EXACT []
xref: UM-BBD_pathwayID:acr
is_a: GO:0006805 ! xenobiotic metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0050898 ! nitrile metabolic process
@@ -140991,7 +141252,6 @@ def: "The chemical reactions and pathways involving benzoate, the anion of benzo
synonym: "benzoate metabolism" EXACT []
xref: MetaCyc:P321-PWY
xref: UM-BBD_pathwayID:benz2
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -141042,7 +141302,6 @@ synonym: "biphenyl metabolism" EXACT []
synonym: "xenene metabolic process" EXACT []
synonym: "xenene metabolism" EXACT []
xref: UM-BBD_pathwayID:bph
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
[Term]
@@ -141062,7 +141321,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai]
synonym: "bromoxynil metabolism" EXACT []
xref: UM-BBD_pathwayID:box
-is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0050898 ! nitrile metabolic process
@@ -141155,7 +141413,6 @@ synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT []
synonym: "propachlor metabolic process" EXACT []
synonym: "propachlor metabolism" EXACT []
xref: UM-BBD_pathwayID:ppc
-is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
@@ -141201,7 +141458,6 @@ def: "The chemical reactions and pathways involving dibenzofuran, a substance co
synonym: "dibenzofuran metabolism" EXACT []
xref: UM-BBD_pathwayID:dbf
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -141218,7 +141474,6 @@ synonym: "phenodioxin metabolic process" EXACT []
synonym: "phenodioxin metabolism" EXACT []
xref: UM-BBD_pathwayID:dpd
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -141232,7 +141487,6 @@ synonym: "dibenzothiophene metabolism" EXACT []
synonym: "diphenylene sulfide metabolic process" EXACT []
synonym: "diphenylene sulfide metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -141247,7 +141501,6 @@ synonym: "dibenzothiophene degradation" EXACT []
xref: UM-BBD_pathwayID:dbt2
is_a: GO:0018895 ! dibenzothiophene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -141299,8 +141552,6 @@ synonym: "2,4-D metabolic process" EXACT []
synonym: "2,4-D metabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:2\,4-d
-is_a: GO:0006805 ! xenobiotic metabolic process
-is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -141377,7 +141628,6 @@ synonym: "DMSO metabolic process" EXACT []
synonym: "DMSO metabolism" EXACT []
xref: UM-BBD_pathwayID:sulf
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0071704 ! organic substance metabolic process
[Term]
@@ -141426,7 +141676,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm]
synonym: "1,4-dichlorobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:dcz
-is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
[Term]
@@ -141474,7 +141723,6 @@ def: "The chemical reactions and pathways involving fluorene, a tricyclic polycy
synonym: "fluorene metabolism" EXACT []
xref: UM-BBD_pathwayID:flu
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
[Term]
@@ -141486,7 +141734,6 @@ synonym: "gallate metabolism" EXACT []
synonym: "gallic acid metabolic process" EXACT []
synonym: "gallic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:gal
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -141499,8 +141746,6 @@ def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachloro
synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
xref: MetaCyc:GAMMAHEXCHLORDEG-PWY
xref: UM-BBD_pathwayID:ghch
-is_a: GO:0016999 ! antibiotic metabolic process
-is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0019497 ! hexachlorocyclohexane metabolic process
[Term]
@@ -141514,7 +141759,6 @@ synonym: "Roundup metabolism" EXACT []
xref: UM-BBD_pathwayID:gly
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006793 ! phosphorus metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0043436 ! oxoacid metabolic process
[Term]
@@ -141534,7 +141778,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [UM-BBD_pathwayID:ipd]
synonym: "iprodione metabolism" EXACT []
xref: UM-BBD_pathwayID:ipd
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process
@@ -141559,7 +141802,6 @@ synonym: "mandelate metabolism" EXACT []
synonym: "mandelic acid metabolic process" EXACT []
synonym: "mandelic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:mca
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
@@ -141632,7 +141874,6 @@ def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, a
synonym: "3-methylquinoline metabolism" EXACT []
xref: UM-BBD_pathwayID:mqn
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
@@ -141644,7 +141885,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide." [http://www.iversonsoftware.com/reference/chemistry/n/Naphthalene.htm]
synonym: "naphthalene metabolism" EXACT []
xref: UM-BBD_pathwayID:naph
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0090420 ! naphthalene-containing compound metabolic process
[Term]
@@ -141653,7 +141893,7 @@ name: nicotine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
synonym: "nicotine metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
+is_a: GO:0008152 ! metabolic process
[Term]
id: GO:0018934
@@ -141694,7 +141934,6 @@ xref: MetaCyc:P201-PWY
xref: UM-BBD_pathwayID:ng
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0071704 ! organic substance metabolic process
[Term]
@@ -141854,7 +142093,6 @@ xref: UM-BBD_pathwayID:pthn
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
-is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
[Term]
@@ -141876,7 +142114,6 @@ synonym: "pentaerythritol tetranitrate metabolism" EXACT []
xref: UM-BBD_pathwayID:petn
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0071704 ! organic substance metabolic process
[Term]
@@ -141887,8 +142124,6 @@ def: "The chemical reactions and pathways involving phenanthrene, a tricyclic ar
synonym: "phenanthrene metabolism" EXACT []
xref: UM-BBD_pathwayID:pha
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0006805 ! xenobiotic metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
[Term]
@@ -141957,7 +142192,6 @@ synonym: "PCP metabolic process" EXACT []
synonym: "PCP metabolism" EXACT []
synonym: "pentachlorophenol metabolism" EXACT []
xref: UM-BBD_pathwayID:pcp
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -141972,7 +142206,6 @@ synonym: "hydrocinnamic acid metabolism" EXACT []
synonym: "phenylpropanoate metabolic process" EXACT []
synonym: "phenylpropanoate metabolism" EXACT []
xref: UM-BBD_pathwayID:ppa
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -142066,7 +142299,6 @@ def: "The chemical reactions and pathways involving toluene, a volatile monoarom
synonym: "methylbenzene metabolic process" EXACT []
synonym: "methylbenzene metabolism" EXACT []
synonym: "toluene metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process
[Term]
@@ -142144,7 +142376,6 @@ synonym: "DDT metabolic process" EXACT []
synonym: "DDT metabolism" EXACT []
xref: UM-BBD_pathwayID:ddt
is_a: GO:0017143 ! insecticide metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -142170,7 +142401,6 @@ synonym: "trichloroethene metabolic process" EXACT []
synonym: "trichloroethene metabolism" EXACT []
synonym: "trichloroethylene metabolism" EXACT []
xref: UM-BBD_pathwayID:tce
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
[Term]
@@ -142182,8 +142412,6 @@ synonym: "2,4,5-T metabolic process" EXACT []
synonym: "2,4,5-T metabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:2\,4\,5-t
-is_a: GO:0006805 ! xenobiotic metabolic process
-is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -142210,7 +142438,6 @@ synonym: "vanillic aldehyde metabolism" EXACT []
synonym: "vanillin metabolism" EXACT []
xref: UM-BBD_pathwayID:van
is_a: GO:0006081 ! cellular aldehyde metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -143367,6 +143594,7 @@ def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic
synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.29]
xref: EC:1.2.1.29
xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN
+xref: RHEA:11804
xref: UM-BBD_reactionID:r0394
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity
@@ -143538,8 +143766,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9]
synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9]
synonym: "tripeptidyl-peptidase I activity" EXACT []
-xref: EC:3.4.14.9
-xref: MetaCyc:3.4.14.9-RXN
is_obsolete: true
replaced_by: GO:0008240
@@ -143555,8 +143781,6 @@ synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102]
synonym: "protease Re" RELATED [EC:3.4.21.102]
synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102]
synonym: "Tsp protease" NARROW [EC:3.4.21.102]
-xref: EC:3.4.21.102
-xref: MetaCyc:3.4.21.102-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -143568,6 +143792,7 @@ def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = be
synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" EXACT [EC:1.14.15.7]
xref: EC:1.14.15.7
xref: MetaCyc:RXN1F-357
+xref: RHEA:17769
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
[Term]
@@ -143595,6 +143820,7 @@ synonym: "DOHH activity" EXACT [EC:1.14.99.29]
xref: EC:1.14.99.29
xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-204662 "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A"
+xref: RHEA:14101
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
@@ -143613,6 +143839,7 @@ synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145]
synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145]
xref: EC:2.7.1.145
xref: MetaCyc:2.7.1.145-RXN
+xref: RHEA:12140
is_a: GO:0019206 ! nucleoside kinase activity
relationship: part_of GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process
@@ -143970,6 +144197,7 @@ synonym: "diamine-ketoglutaric transaminase activity" EXACT [EC:2.6.1.29]
synonym: "diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.29]
xref: EC:2.6.1.29
xref: MetaCyc:DIAMTRANSAM-RXN
+xref: RHEA:18217
is_a: GO:0008483 ! transaminase activity
[Term]
@@ -144017,6 +144245,7 @@ synonym: "pyruvic-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1]
xref: EC:1.2.7.1
xref: KEGG_REACTION:R01196
xref: MetaCyc:PYRUFLAVREDUCT-RXN
+xref: RHEA:12765
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
relationship: part_of GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate
@@ -144050,6 +144279,7 @@ xref: MetaCyc:TRANSENOYLCOARED-RXN
xref: Reactome:R-HSA-6786720 "DECR2 reduces LCtE-CoA to t3enoyl-CoA"
xref: Reactome:R-HSA-6809810 "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA"
xref: Reactome:R-HSA-8952873 "MECR dimer reduces tdec2-CoA to DEC-CoA"
+xref: RHEA:33763
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -144058,6 +144288,7 @@ name: 2-octaprenylphenol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN]
xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN
+xref: RHEA:27790
is_a: GO:0016491 ! oxidoreductase activity
[Term]
@@ -144089,11 +144320,13 @@ is_a: GO:0016836 ! hydro-lyase activity
id: GO:0019172
name: glyoxalase III activity
namespace: molecular_function
-def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [EC:4.2.1.130, GOC:mcc, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130, MetaCyc:GLYOXIII-RXN, PMID:21696459, PMID:7848303, RHEA:27754]
+def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [GOC:mcc, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130, PMID:21696459, PMID:7848303, RHEA:27754]
comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC:4.4.1.5 (lactoylglutathione lyase) and EC:3.1.2.6 (hydroxyacylglutathione hydrolase).
synonym: "(R)-lactate hydro-lyase" EXACT []
synonym: "D-lactate dehydratase" EXACT []
synonym: "glutathione-independent glyoxalase activity" RELATED []
+xref: EC:4.2.1.130
+xref: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130
xref: MetaCyc:GLYOXIII-RXN
xref: RHEA:27754
is_a: GO:0016836 ! hydro-lyase activity
@@ -144115,6 +144348,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN]
synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT []
xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN
+xref: RHEA:25306
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
[Term]
@@ -144123,6 +144357,7 @@ name: dihydroneopterin triphosphate pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN]
xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN
+xref: RHEA:25302
is_a: GO:0016462 ! pyrophosphatase activity
[Term]
@@ -144180,8 +144415,6 @@ name: histamine-gated chloride channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005254 ! chloride channel activity
-is_a: GO:0022835 ! transmitter-gated channel activity
-is_a: GO:0099095 ! ligand-gated anion channel activity
[Term]
id: GO:0019183
@@ -144189,7 +144422,7 @@ name: histamine-gated chloride channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034707 ! chloride channel complex
-is_a: GO:0098878 ! neurotransmitter receptor complex
+is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of GO:0005887 ! integral component of plasma membrane
[Term]
@@ -144271,7 +144504,6 @@ id: GO:0019198
name: transmembrane receptor protein phosphatase activity
namespace: molecular_function
def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate." [GOC:hjd]
-xref: EC:3.1.3
is_a: GO:0004721 ! phosphoprotein phosphatase activity
is_a: GO:0004888 ! transmembrane signaling receptor activity
@@ -144847,7 +145079,6 @@ synonym: "acrylonitrile breakdown" EXACT []
synonym: "acrylonitrile catabolism" EXACT []
synonym: "acrylonitrile degradation" EXACT []
xref: MetaCyc:P344-PWY
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0018865 ! acrylonitrile metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0050899 ! nitrile catabolic process
@@ -144899,7 +145130,6 @@ synonym: "1,4-dichlorobenzene degradation" EXACT []
xref: MetaCyc:14DICHLORBENZDEG-PWY
is_a: GO:0018912 ! 1,4-dichlorobenzene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
-is_a: GO:0046701 ! insecticide catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
[Term]
@@ -144912,10 +145142,9 @@ synonym: "N-acetylneuraminate catabolism" EXACT []
synonym: "N-acetylneuraminate degradation" EXACT []
xref: MetaCyc:P441-PWY
is_a: GO:0006054 ! N-acetylneuraminate metabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046348 ! amino sugar catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
+is_a: GO:1901565 ! organonitrogen compound catabolic process
[Term]
id: GO:0019263
@@ -145018,7 +145247,6 @@ synonym: "aerobactin synthesis" EXACT []
xref: MetaCyc:AEROBACTINSYN-PWY
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0046442 ! aerobactin metabolic process
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
[Term]
@@ -145027,7 +145255,6 @@ name: aerobactin transport
namespace: biological_process
def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai, PMID:23192658]
is_a: GO:0006842 ! tricarboxylic acid transport
-is_a: GO:0051181 ! cofactor transport
is_a: GO:0072337 ! modified amino acid transport
[Term]
@@ -145257,7 +145484,6 @@ synonym: "siderophore synthesis" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
[Term]
id: GO:0019292
@@ -145318,7 +145544,6 @@ synonym: "coenzyme M biosynthesis" EXACT []
synonym: "coenzyme M formation" EXACT []
synonym: "coenzyme M synthesis" EXACT []
xref: MetaCyc:P261-PWY
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019296 ! coenzyme M metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
@@ -145330,7 +145555,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators]
synonym: "coenzyme M metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
[Term]
@@ -145340,7 +145564,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators]
synonym: "coenzyme B metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006793 ! phosphorus metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
@@ -145354,7 +145577,6 @@ synonym: "coenzyme B biosynthesis" EXACT []
synonym: "coenzyme B formation" EXACT []
synonym: "coenzyme B synthesis" EXACT []
xref: MetaCyc:P241-PWY
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019297 ! coenzyme B metabolic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
@@ -145809,7 +146031,6 @@ synonym: "pentachlorophenol breakdown" EXACT []
synonym: "pentachlorophenol catabolism" EXACT []
synonym: "pentachlorophenol degradation" EXACT []
xref: MetaCyc:PCPDEG-PWY
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0018961 ! pentachlorophenol metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
@@ -145825,8 +146046,6 @@ xref: MetaCyc:PARATHION-DEGRADATION-PWY
is_a: GO:0018952 ! parathion metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
-is_a: GO:0046701 ! insecticide catabolic process
-is_a: GO:0051410 ! detoxification of nitrogen compound
[Term]
id: GO:0019340
@@ -146105,7 +146324,6 @@ synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT []
xref: MetaCyc:P2-PWY
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process
@@ -146115,7 +146333,6 @@ name: pyridine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]
synonym: "pyridine nucleotide metabolism" EXACT []
-is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
@@ -146129,7 +146346,6 @@ synonym: "pyridine nucleotide biosynthesis" EXACT []
synonym: "pyridine nucleotide formation" EXACT []
synonym: "pyridine nucleotide synthesis" EXACT []
xref: MetaCyc:PYRIDNUCSYN-PWY
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0019362 ! pyridine nucleotide metabolic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
@@ -146142,7 +146358,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of a pyridi
synonym: "pyridine nucleotide breakdown" EXACT []
synonym: "pyridine nucleotide catabolism" EXACT []
synonym: "pyridine nucleotide degradation" EXACT []
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0019362 ! pyridine nucleotide metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
@@ -146282,7 +146497,6 @@ synonym: "3-phenylpropionate catabolism" EXACT []
synonym: "3-phenylpropionate degradation" EXACT []
xref: MetaCyc:HCAMHPDEG-PWY
xref: MetaCyc:P281-PWY
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0018962 ! 3-phenylpropionate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
@@ -146481,7 +146695,6 @@ synonym: "gallic acid catabolic process" EXACT []
synonym: "gallic acid catabolism" EXACT []
is_a: GO:0018918 ! gallate metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
[Term]
@@ -146668,7 +146881,6 @@ synonym: "acetate biosynthesis" EXACT []
synonym: "acetate formation" EXACT []
synonym: "acetate synthesis" EXACT []
is_a: GO:0006083 ! acetate metabolic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
[Term]
@@ -146690,7 +146902,6 @@ synonym: "acetate formation from carbon monoxide" EXACT []
synonym: "acetate synthesis from carbon monoxide" EXACT []
synonym: "carbon monoxide dehydrogenase pathway" EXACT []
is_a: GO:0019413 ! acetate biosynthetic process
-is_a: GO:0042133 ! neurotransmitter metabolic process
[Term]
id: GO:0019416
@@ -146825,7 +147036,6 @@ xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY
is_a: GO:0018917 ! fluorene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
[Term]
@@ -147348,7 +147558,6 @@ synonym: "L-lysine breakdown" EXACT []
synonym: "L-lysine catabolism" EXACT []
synonym: "L-lysine degradation" EXACT []
is_a: GO:0006554 ! lysine catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046440 ! L-lysine metabolic process
[Term]
@@ -147398,7 +147607,6 @@ def: "The chemical reactions and pathways involving beta-alanine (3-aminopropano
synonym: "beta-alanine metabolism" EXACT []
xref: Wikipedia:Beta-alanine
is_a: GO:0006520 ! cellular amino acid metabolic process
-is_a: GO:0042133 ! neurotransmitter metabolic process
[Term]
id: GO:0019483
@@ -147411,7 +147619,6 @@ synonym: "beta-alanine formation" EXACT []
synonym: "beta-alanine synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0019482 ! beta-alanine metabolic process
-is_a: GO:0042136 ! neurotransmitter biosynthetic process
[Term]
id: GO:0019484
@@ -147423,7 +147630,6 @@ synonym: "beta-alanine catabolism" EXACT []
synonym: "beta-alanine degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0019482 ! beta-alanine metabolic process
-is_a: GO:0042135 ! neurotransmitter catabolic process
[Term]
id: GO:0019485
@@ -147716,7 +147922,6 @@ is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process
-is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:1901606 ! alpha-amino acid catabolic process
[Term]
@@ -147790,7 +147995,6 @@ synonym: "threonine catabolic process to D-lactate" BROAD [GOC:bf]
xref: MetaCyc:THRDLCTCAT-PWY
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0006567 ! threonine catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0019518
@@ -147805,7 +148009,6 @@ synonym: "threonine catabolic process to glycine" BROAD [GOC:bf]
xref: MetaCyc:THREONINE-DEG2-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0006567 ! threonine catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0019519
@@ -147916,7 +148119,6 @@ synonym: "taurine catabolism" EXACT []
synonym: "taurine degradation" EXACT []
xref: MetaCyc:TAURINEDEG-PWY
is_a: GO:0019530 ! taurine metabolic process
-is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046306 ! alkanesulfonate catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
@@ -147926,7 +148128,6 @@ name: taurine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
synonym: "taurine metabolism" EXACT []
-is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0019694 ! alkanesulfonate metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
@@ -148001,7 +148202,6 @@ is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0019536 ! vibriobactin metabolic process
is_a: GO:0043604 ! amide biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
@@ -148068,7 +148268,6 @@ def: "The chemical reactions and pathways involving propionate, the anion derive
synonym: "propanoate metabolic process" EXACT []
synonym: "propanoate metabolism" EXACT []
synonym: "propionate metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0046459 ! short-chain fatty acid metabolic process
[Term]
@@ -148080,7 +148279,6 @@ synonym: "propionate anabolism" EXACT []
synonym: "propionate biosynthesis" EXACT []
synonym: "propionate formation" EXACT []
synonym: "propionate synthesis" EXACT []
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process
@@ -148092,10 +148290,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of propiona
synonym: "propionate breakdown" EXACT []
synonym: "propionate catabolism" EXACT []
synonym: "propionate degradation" EXACT []
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0019626 ! short-chain fatty acid catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0019544
@@ -148651,7 +148847,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of mandelat
synonym: "mandelate breakdown" EXACT []
synonym: "mandelate catabolism" EXACT []
synonym: "mandelate degradation" EXACT []
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0018924 ! mandelate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
@@ -148665,7 +148860,6 @@ namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators]
synonym: "(R)-mandelate breakdown to benzoate" EXACT []
synonym: "(R)-mandelate degradation to benzoate" EXACT []
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018874 ! benzoate metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0019596 ! mandelate catabolic process
@@ -148787,8 +148981,8 @@ synonym: "nicotine catabolism" EXACT []
synonym: "nicotine degradation" EXACT []
xref: MetaCyc:P181-PWY
xref: UM-BBD_pathwayID:nic
+is_a: GO:0009056 ! catabolic process
is_a: GO:0018933 ! nicotine metabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0019609
@@ -148912,7 +149106,6 @@ synonym: "protocatechuate catabolic process" EXACT []
synonym: "protocatechuate catabolism" EXACT []
synonym: "protocatechuate degradation" EXACT []
is_a: GO:0019614 ! catechol-containing compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
@@ -149110,7 +149303,6 @@ def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a
synonym: "phosphonoacetate metabolism" EXACT []
xref: MetaCyc:P483-PWY
is_a: GO:0006793 ! phosphorus metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
[Term]
@@ -149255,7 +149447,6 @@ def: "The anaerobic chemical reactions and pathways resulting in the breakdown o
synonym: "citrate fermentation to diacetyl" EXACT []
synonym: "diacetyl fermentation" EXACT []
is_a: GO:0006101 ! citrate metabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0019662 ! non-glycolytic fermentation
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0072352 ! tricarboxylic acid catabolic process
@@ -149728,7 +149919,6 @@ name: choline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
synonym: "choline metabolism" EXACT []
-is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0071704 ! organic substance metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
@@ -149839,6 +150029,7 @@ synonym: "protein-cysteine S-palmitoleyltransferase activity" RELATED []
xref: EC:2.3.1.225
xref: Reactome:R-HSA-5682084 "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer"
xref: Reactome:R-HSA-9021072 "ZDHHC7, ZDHHC21 palmitoylate ESR1"
+xref: Reactome:R-HSA-9647982 "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated"
xref: RHEA:36683
is_a: GO:0016409 ! palmitoyltransferase activity
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity
@@ -150205,6 +150396,7 @@ subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
+subset: goslim_pombe
synonym: "secondary metabolism" EXACT []
synonym: "secondary metabolite metabolic process" EXACT []
synonym: "secondary metabolite metabolism" EXACT []
@@ -150629,6 +150821,7 @@ xref: Reactome:R-HSA-3000399 "RANBP2 SUMOylates SP100 with SUMO1"
xref: Reactome:R-HSA-3000411 "RANBP2 SUMOylates PML with SUMO2"
xref: Reactome:R-HSA-3000433 "SUMOylation of PML with SUMO3"
xref: Reactome:R-HSA-3000434 "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1"
+xref: Reactome:R-HSA-3000449 "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2"
xref: Reactome:R-HSA-3108203 "PRC1 SUMOylates CTBP1 with SUMO2,3"
xref: Reactome:R-HSA-3108209 "PRC1 SUMOylates CTBP1 with SUMO1"
xref: Reactome:R-HSA-3108212 "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1"
@@ -150845,6 +151038,7 @@ xref: EC:1.14.11.7
xref: KEGG_REACTION:R03218
xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN
xref: Reactome:R-HSA-1980233 "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen"
+xref: RHEA:22872
is_a: GO:0019798 ! procollagen-proline dioxygenase activity
is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity
@@ -150870,6 +151064,7 @@ synonym: "TAT activity" EXACT [EC:2.3.1.108]
synonym: "tubulin acetyltransferase activity" EXACT [EC:2.3.1.108]
xref: EC:2.3.1.108
xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN
+xref: RHEA:15277
is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity
[Term]
@@ -151122,7 +151317,6 @@ subset: goslim_pir
subset: goslim_plant
synonym: "cytochrome P450" NARROW []
synonym: "cytochrome P450 activity" RELATED []
-is_a: GO:0008144 ! drug binding
is_a: GO:0036094 ! small molecule binding
[Term]
@@ -151383,7 +151577,6 @@ synonym: "L-ascorbic acid metabolism" EXACT []
synonym: "vitamin C metabolic process" EXACT []
synonym: "vitamin C metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
@@ -151401,7 +151594,6 @@ synonym: "L-ascorbic acid synthesis" EXACT []
synonym: "vitamin C biosynthesis" EXACT []
synonym: "vitamin C biosynthetic process" EXACT []
xref: MetaCyc:PWY-882
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
@@ -151420,7 +151612,6 @@ synonym: "L-ascorbic acid degradation" EXACT []
synonym: "vitamin C catabolic process" EXACT []
synonym: "vitamin C catabolism" EXACT []
xref: MetaCyc:PWY0-301
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
@@ -151481,7 +151672,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
synonym: "uracil metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine nucleobase metabolic process
-is_a: GO:0017144 ! drug metabolic process
[Term]
id: GO:0019861
@@ -152410,8 +152600,8 @@ is_a: GO:0019961 ! interferon binding
id: GO:0019964
name: interferon-gamma binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383, PR:000000017]
-synonym: "IFN-gamma binding" EXACT [GOC:mah, PR:000000017]
+def: "Interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383]
+synonym: "IFN-gamma binding" EXACT [GOC:mah]
synonym: "IFNG binding" EXACT [GOC:mah]
synonym: "type II interferon binding" BROAD [PMID:15546383, PR:000024990]
is_a: GO:0019961 ! interferon binding
@@ -152897,7 +153087,6 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]
synonym: "haem binding" EXACT []
is_a: GO:0046906 ! tetrapyrrole binding
-is_a: GO:0048037 ! cofactor binding
[Term]
id: GO:0020038
@@ -158401,7 +158590,8 @@ comment: Note that this term represents an activity and not a gene product. Cons
synonym: "5-hydroxytryptamine-gated receptor-channel" NARROW []
synonym: "serotonin-activated cation-selective channel activity" EXACT []
synonym: "serotonin-gated cation channel activity" NARROW []
-xref: Reactome:R-HSA-975311 "HTR3 pentamer:5HT transports Na+,K+, and Ca2+"
+xref: Reactome:R-HSA-9648983 "HTR3A pentamer:5HT transports Na+,K+,Ca2+"
+xref: Reactome:R-HSA-975311 "HTR3 pentamers:5HT transport Na+,K+,Ca2+"
is_a: GO:0022824 ! transmitter-gated ion channel activity
is_a: GO:0099094 ! ligand-gated cation channel activity
relationship: part_of GO:0007210 ! serotonin receptor signaling pathway
@@ -158620,6 +158810,7 @@ namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "sucrose PTS transporter activity" EXACT []
xref: MetaCyc:SUCROSEPHOSPHO-RXN
+xref: RHEA:49236
is_a: GO:0008515 ! sucrose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
@@ -159654,8 +159845,6 @@ synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59]
synonym: "skin tryptase activity" NARROW [EC:3.4.21.59]
synonym: "tryptase activity" EXACT []
synonym: "tryptase M" RELATED [EC:3.4.21.59]
-xref: EC:3.4.21.59
-xref: MetaCyc:3.4.21.59-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -160004,6 +160193,7 @@ synonym: "dehydrogenase, arylamine (azurin) activity" EXACT [EC:1.4.9.2]
synonym: "tyramine dehydrogenase (azurin) activity" NARROW [EC:1.4.9.2]
xref: EC:1.4.9.2
xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN
+xref: RHEA:47796
is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor
[Term]
@@ -160986,6 +161176,7 @@ synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" EXACT [EC
xref: EC:2.4.2.26
xref: MetaCyc:2.4.2.26-RXN
xref: Reactome:R-HSA-1878002 "XYLTs transfer Xyl to core protein"
+xref: RHEA:50192
is_a: GO:0035252 ! UDP-xylosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -160999,6 +161190,7 @@ synonym: "receptor signaling complex scaffold activity" EXACT []
synonym: "receptor signaling complex scaffold protein activity" EXACT []
synonym: "receptor signalling complex scaffold activity" EXACT []
is_a: GO:0035591 ! signaling adaptor activity
+relationship: has_part GO:0005102 ! signaling receptor binding
[Term]
id: GO:0030160
@@ -161119,7 +161311,6 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]
subset: goslim_metagenomics
is_a: GO:0043168 ! anion binding
-is_a: GO:0050662 ! coenzyme binding
is_a: GO:0070279 ! vitamin B6 binding
[Term]
@@ -161292,7 +161483,6 @@ id: GO:0030184
name: nitric oxide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah]
-is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity
relationship: part_of GO:0030185 ! nitric oxide transport
@@ -161301,8 +161491,6 @@ id: GO:0030185
name: nitric oxide transport
namespace: biological_process
def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
-is_a: GO:0006836 ! neurotransmitter transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0071705 ! nitrogen compound transport
[Term]
@@ -161311,7 +161499,6 @@ name: melatonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]
synonym: "melatonin metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
@@ -161552,7 +161739,6 @@ synonym: "dermatan sulfate metabolism" EXACT []
synonym: "dermatan sulphate metabolic process" EXACT []
synonym: "dermatan sulphate metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1903510 ! mucopolysaccharide metabolic process
relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process
@@ -161620,7 +161806,6 @@ synonym: "dermatan sulphate catabolic process" EXACT []
synonym: "dermatan sulphate catabolism" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030205 ! dermatan sulfate metabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
@@ -162274,8 +162459,6 @@ synonym: "SK protease activity" EXACT [EC:3.4.21.39]
synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39]
synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39]
synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39]
-xref: EC:3.4.21.39
-xref: MetaCyc:3.4.21.39-RXN
is_obsolete: true
replaced_by: GO:0004252
@@ -162587,8 +162770,6 @@ synonym: "MMP-10" EXACT []
synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22]
synonym: "stromelysin 2 activity" EXACT []
synonym: "transin 2 activity" EXACT [EC:3.4.24.22]
-xref: EC:3.4.24.22
-xref: MetaCyc:3.4.24.22-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -162743,12 +162924,18 @@ is_a: GO:0002573 ! myeloid leukocyte differentiation
id: GO:0030317
name: flagellated sperm motility
namespace: biological_process
-def: "Any process involved in the controlled movement of a flagellated sperm cell." [GOC:cilia, GOC:jl, GOC:krc]
+alt_id: GO:0097724
+alt_id: GO:1905419
+def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]
synonym: "flagellated sperm movement" EXACT []
+synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc]
+synonym: "sperm flagellum movement involved in flagellated sperm motility" EXACT []
+synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie]
synonym: "sperm motility" BROAD []
synonym: "sperm movement" BROAD []
xref: Wikipedia:Sperm_motility
is_a: GO:0060285 ! cilium-dependent cell motility
+is_a: GO:0060294 ! cilium movement involved in cell motility
is_a: GO:0097722 ! sperm motility
[Term]
@@ -162953,6 +163140,7 @@ synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity
synonym: "N-acetylneuraminic monooxygenase activity" EXACT [EC:1.14.18.2]
xref: EC:1.14.18.2
xref: MetaCyc:1.14.13.45-RXN
+xref: RHEA:16145
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
[Term]
@@ -162966,6 +163154,7 @@ synonym: "fatty-acyl ethyl ester synthase" EXACT [GOC:mah]
synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" EXACT [EC:3.1.1.67]
xref: EC:3.1.1.67
xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN
+xref: RHEA:16641
is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
@@ -162980,6 +163169,7 @@ synonym: "mucinase activity" EXACT [EC:4.2.2.1]
synonym: "spreading factor activity" RELATED [EC:4.2.2.1]
xref: EC:4.2.2.1
xref: MetaCyc:HYALURONATE-LYASE-RXN
+xref: RHEA:50240
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides
[Term]
@@ -163018,6 +163208,7 @@ synonym: "cholecalciferol 25-hydroxylase activity" EXACT []
xref: MetaCyc:RXN-9829
xref: Reactome:R-HSA-209845 "CYP2R1 25-hydroxylates VD3 to 25(OH)D"
xref: Reactome:R-HSA-5602147 "Defective CYP2R1 does not 25-hydroxylate vitamin D"
+xref: RHEA:32903
is_a: GO:0070643 ! vitamin D 25-hydroxylase activity
relationship: part_of GO:0036378 ! calcitriol biosynthetic process from calciol
@@ -163057,7 +163248,6 @@ id: GO:0030351
name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai]
-xref: EC:3.1.3
xref: Reactome:R-HSA-1855163 "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen"
is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity
@@ -163066,7 +163256,6 @@ id: GO:0030352
name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai]
-xref: EC:3.1.3
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity
[Term]
@@ -163153,6 +163342,7 @@ namespace: molecular_function
def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783]
xref: EC:2.8.1.12
xref: Reactome:R-HSA-947541 "Sulfhydrylation and ring cleavage of precursor Z"
+xref: RHEA:26333
is_a: GO:0016783 ! sulfurtransferase activity
[Term]
@@ -163267,7 +163457,8 @@ namespace: molecular_function
def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd]
xref: EC:5.1.1.18
xref: MetaCyc:5.1.1.18-RXN
-xref: Reactome:R-HSA-9014766 "SRR dimer:PXLP isomerises L-Ser to D-Ser"
+xref: Reactome:R-HSA-9014766 "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser"
+xref: RHEA:10980
is_a: GO:0047661 ! amino-acid racemase activity
[Term]
@@ -163477,7 +163668,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "matrilysin-2 activity" EXACT []
synonym: "matrix metalloproteinase 26" EXACT []
synonym: "MMP-26" EXACT []
-xref: EC:3.4.24
is_obsolete: true
replaced_by: GO:0004222
@@ -163563,6 +163753,7 @@ synonym: "glutamate formiminotransferase activity" EXACT []
synonym: "glutamate formyltransferase activity" EXACT [EC:2.1.2.5]
xref: EC:2.1.2.5
xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN
+xref: RHEA:15097
is_a: GO:0030407 ! formimidoyltransferase activity
[Term]
@@ -163652,7 +163843,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
synonym: "nicotianamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -163682,7 +163872,6 @@ synonym: "nicotianamine catabolism" EXACT []
synonym: "nicotianamine degradation" EXACT []
is_a: GO:0030417 ! nicotianamine metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072352 ! tricarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -164440,7 +164629,7 @@ id: GO:0030509
name: BMP signaling pathway
namespace: biological_process
alt_id: GO:0008101
-def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827, PR:000000034]
+def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]
synonym: "BMP receptor signaling pathway" RELATED []
synonym: "BMP signalling pathway" EXACT []
synonym: "bone morphogenetic protein signaling pathway" EXACT []
@@ -165104,6 +165293,7 @@ synonym: "bile acid catabolism" EXACT []
synonym: "bile acid degradation" EXACT []
synonym: "cholate catabolic process" NARROW []
xref: MetaCyc:7ALPHADEHYDROX-PWY
+is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
@@ -165265,6 +165455,7 @@ synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ ox
xref: EC:1.16.1.8
xref: MetaCyc:2.1.1.135-RXN
xref: Reactome:R-HSA-3149518 "MTRR reduces cob(II)alamin to meCbl"
+xref: RHEA:23908
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
[Term]
@@ -165399,6 +165590,7 @@ synonym: "pectin pectylhydrolase activity" EXACT [EC:3.1.1.11]
synonym: "pectinoesterase activity" EXACT [EC:3.1.1.11]
xref: EC:3.1.1.11
xref: MetaCyc:PECTINESTERASE-RXN
+xref: RHEA:22380
is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
@@ -165432,8 +165624,6 @@ synonym: "arylamidase II" RELATED [EC:3.4.11.6]
synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6]
synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6]
synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6]
-xref: EC:3.4.11.6
-xref: MetaCyc:3.4.11.6-RXN
is_obsolete: true
replaced_by: GO:0004177
@@ -165446,8 +165636,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "chymosin activity" EXACT []
synonym: "rennin" RELATED [EC:3.4.23.4]
synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4]
-xref: EC:3.4.23.4
-xref: MetaCyc:3.4.23.4-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -165819,7 +166007,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]
synonym: "aminoglycoside antibiotic metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
[Term]
id: GO:0030648
@@ -165939,7 +166126,6 @@ def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "regulation of coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true
-consider: GO:0051196
consider: GO:0051199
[Term]
@@ -166093,14 +166279,14 @@ relationship: part_of GO:0044304 ! main axon
id: GO:0030674
name: protein-macromolecule adaptor activity
namespace: molecular_function
-def: "The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]
+def: "The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_yeast
synonym: "protein binding, bridging" EXACT []
synonym: "protein-protein adaptor" NARROW []
-is_a: GO:0005515 ! protein binding
is_a: GO:0060090 ! molecular adaptor activity
+relationship: has_part GO:0005515 ! protein binding
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18655 xsd:anyURI
[Term]
@@ -166372,6 +166558,7 @@ synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35]
xref: EC:2.1.1.35
xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN
+xref: RHEA:42712
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity
@@ -166417,6 +166604,7 @@ synonym: "NAD-azoferredoxin (ADPribose)transferase activity" EXACT [EC:2.4.2.37]
synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.37
xref: MetaCyc:2.4.2.37-RXN
+xref: RHEA:18077
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
[Term]
@@ -166762,6 +166950,7 @@ synonym: "fatty-acid O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" EXACT [EC:2.1.1.15]
xref: EC:2.1.1.15
xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN
+xref: RHEA:23012
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -166945,6 +167134,7 @@ synonym: "isoflavone O-methyltransferase activity" EXACT [EC:2.1.1.46]
synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.46]
xref: EC:2.1.1.46
xref: MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN
+xref: RHEA:31739
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -167032,6 +167222,7 @@ synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" EXACT
synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" EXACT [EC:2.1.1.69]
xref: EC:2.1.1.69
xref: MetaCyc:2.1.1.69-RXN
+xref: RHEA:11808
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -167330,6 +167521,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-gluc
synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" EXACT [EC:2.1.1.112]
xref: EC:2.1.1.112
xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN
+xref: RHEA:20413
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -167453,6 +167645,7 @@ synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizin
synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.127]
xref: EC:2.1.1.127
xref: MetaCyc:2.1.1.127-RXN
+xref: RHEA:50996
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -167518,6 +167711,7 @@ synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity"
synonym: "trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136]
xref: EC:2.1.1.136
xref: MetaCyc:2.1.1.136-RXN
+xref: RHEA:18909
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -167533,6 +167727,7 @@ xref: EC:2.1.1.137
xref: MetaCyc:2.1.1.137-RXN
xref: Reactome:R-HSA-5696213 "AS3MT transfers CH3 from AdoMet to methylarsonite"
xref: Reactome:R-HSA-5696220 "AS3MT transfers CH3 from AdoMet to arsenite(3-)"
+xref: RHEA:15293
xref: UM-BBD_reactionID:r0805
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
@@ -169680,7 +169875,6 @@ is_a: GO:0015695 ! organic cation transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0045117 ! azole transmembrane transport
-is_a: GO:0051181 ! cofactor transport
is_a: GO:0072348 ! sulfur compound transport
is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport
is_a: GO:0098655 ! cation transmembrane transport
@@ -169693,7 +169887,6 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg]
synonym: "thiamin binding" EXACT []
synonym: "vitamin B1 binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0019842 ! vitamin binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
@@ -169712,7 +169905,6 @@ synonym: "TPP binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043169 ! cation binding
-is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding
@@ -169940,16 +170132,14 @@ def: "The cell cycle process in which linear elements are assembled in associati
synonym: "linear element formation" RELATED [GOC:dph]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1903046 ! meiotic cell cycle process
-relationship: part_of GO:0007129 ! synapsis
+relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis
[Term]
id: GO:0031000
name: response to caffeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:ef, GOC:mah]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0014074 ! response to purine-containing compound
-is_a: GO:0036270 ! response to diuretic
is_a: GO:0043279 ! response to alkaloid
[Term]
@@ -170688,7 +170878,8 @@ synonym: "NIFS" RELATED [EC:2.8.1.7]
synonym: "SufS" RELATED [EC:2.8.1.7]
xref: EC:2.8.1.7
xref: Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster"
-xref: Reactome:R-HSA-947514 "NFS1 transfers sulfur from cysteine onto MOCS3"
+xref: Reactome:R-HSA-947514 "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3"
+xref: RHEA:43892
is_a: GO:0016783 ! sulfurtransferase activity
[Term]
@@ -170764,7 +170955,6 @@ synonym: "protease 3C" RELATED [EC:3.4.22.28]
synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28]
-xref: EC:3.4.22.28
is_obsolete: true
replaced_by: GO:0004197
@@ -171754,6 +171944,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O." [MetaCyc:RXN-11128, PMID:12828635]
synonym: "L-ornithine 5-monooxygenase activity" EXACT [MetaCyc:RXN-11128]
xref: MetaCyc:RXN-11128
+xref: RHEA:41508
is_a: GO:0004497 ! monooxygenase activity
[Term]
@@ -171816,7 +172007,6 @@ def: "Interacting selectively and non-covalently with phosphopantetheine, the vi
is_a: GO:0019842 ! vitamin binding
is_a: GO:0033218 ! amide binding
is_a: GO:0043168 ! anion binding
-is_a: GO:0048037 ! cofactor binding
is_a: GO:0072341 ! modified amino acid binding
[Term]
@@ -171998,6 +172188,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846]
xref: MetaCyc:RXN-9025
xref: MetaCyc:RXN0-5182
+xref: RHEA:29691
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity
[Term]
@@ -174121,7 +174312,6 @@ name: lipoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732]
is_a: GO:0005504 ! fatty acid binding
-is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
is_a: GO:1901681 ! sulfur compound binding
@@ -174257,7 +174447,6 @@ synonym: "vitamin C binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0048029 ! monosaccharide binding
-is_a: GO:0050662 ! coenzyme binding
[Term]
id: GO:0031419
@@ -174265,10 +174454,8 @@ name: cobalamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]
synonym: "vitamin B12 binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0019842 ! vitamin binding
is_a: GO:0046906 ! tetrapyrrole binding
-is_a: GO:0048037 ! cofactor binding
[Term]
id: GO:0031420
@@ -174334,11 +174521,8 @@ id: GO:0031427
name: response to methotrexate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:ef, GOC:mah, ISBN:0198506732]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097327 ! response to antineoplastic agent
-is_a: GO:0097329 ! response to antimetabolite
is_a: GO:1901700 ! response to oxygen-containing compound
[Term]
@@ -174841,9 +175025,10 @@ is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
id: GO:0031470
name: carboxysome
namespace: cellular_component
-def: "An organelle consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708]
+def: "An organelle consisting of a proteinaceous coat and enzymes for the fixation of CO(2). It augments the concentration of CO(2) in the vicinity of RuBisCO to increase the efficiency of CO(2) fixation under atmospheric conditions." [GOC:js, PMID:28934381, PMID:8157606, PMID:8491708]
xref: Wikipedia:Carboxysome
is_a: GO:0031469 ! polyhedral organelle
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19743 xsd:anyURI
[Term]
id: GO:0031471
@@ -175210,6 +175395,7 @@ synonym: "heterochromatic silencing at centromere" EXACT []
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0031055 ! chromatin remodeling at centromere
is_a: GO:0031507 ! heterochromatin assembly
+is_a: GO:0140462 ! pericentric heterochromatin organization
relationship: part_of GO:0034508 ! centromere complex assembly
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18954 xsd:anyURI
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19112 xsd:anyURI
@@ -175231,6 +175417,8 @@ synonym: "subtelomeric silencing" EXACT [GOC:mah]
synonym: "telomeric heterochromatin assembly" RELATED []
synonym: "telomeric heterochromatin formation" RELATED []
is_a: GO:0031507 ! heterochromatin assembly
+is_a: GO:0032202 ! telomere assembly
+is_a: GO:0140461 ! subtelomeric heterochromatin organization
relationship: part_of GO:0032200 ! telomere organization
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19188 xsd:anyURI
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19308 xsd:anyURI
@@ -175360,7 +175548,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah]
synonym: "menthol metabolism" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process
[Term]
@@ -176612,6 +176799,7 @@ subset: goslim_pir
synonym: "killing of cells of another organism" EXACT [GOC:bf]
synonym: "killing of cells of another, non-host, organism" NARROW []
is_a: GO:0001906 ! cell killing
+is_a: GO:0044419 ! interspecies interaction between organisms
[Term]
id: GO:0031641
@@ -179022,7 +179210,6 @@ id: GO:0031919
name: vitamin B6 transport
namespace: biological_process
def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
-is_a: GO:0015893 ! drug transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -179035,7 +179222,6 @@ def: "The directed movement of pyridoxal into, out of or within a cell, or betwe
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport
-is_a: GO:0051181 ! cofactor transport
[Term]
id: GO:0031921
@@ -179046,7 +179232,6 @@ is_a: GO:0015711 ! organic anion transport
is_a: GO:0015748 ! organophosphate ester transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport
-is_a: GO:0051182 ! coenzyme transport
[Term]
id: GO:0031922
@@ -179064,7 +179249,6 @@ namespace: biological_process
def: "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0031919 ! vitamin B6 transport
-is_a: GO:0051181 ! cofactor transport
[Term]
id: GO:0031924
@@ -179082,8 +179266,6 @@ namespace: molecular_function
def: "Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
synonym: "pyridoxal transporter activity" BROAD []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
-is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:1903090 ! pyridoxal transmembrane transport
@@ -179094,8 +179276,6 @@ namespace: molecular_function
def: "Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
-is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
[Term]
@@ -179104,7 +179284,6 @@ name: pyridoxamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0015101 ! organic cation transmembrane transporter activity
-is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:1903091 ! pyridoxamine transmembrane transport
@@ -179114,8 +179293,6 @@ name: pyridoxine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
synonym: "pyridoxine transporter activity" BROAD []
-is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:1903092 ! pyridoxine transmembrane transport
@@ -180418,6 +180595,7 @@ id: GO:0032052
name: bile acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:rph]
+is_a: GO:0005496 ! steroid binding
is_a: GO:0033293 ! monocarboxylic acid binding
[Term]
@@ -182212,6 +182390,7 @@ namespace: molecular_function
def: "Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]
synonym: "riboflavin transporter activity" RELATED []
xref: Reactome:R-HSA-3165230 "SLC52A1,2,3 transport RIB from extracellular region to cytosol"
+xref: RHEA:35015
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
relationship: part_of GO:0032218 ! riboflavin transport
@@ -182222,7 +182401,6 @@ name: riboflavin transport
namespace: biological_process
def: "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]
is_a: GO:0015711 ! organic anion transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -182494,7 +182672,6 @@ name: adenosine transport
namespace: biological_process
def: "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015858 ! nucleoside transport
-is_a: GO:0015893 ! drug transport
[Term]
id: GO:0032239
@@ -182629,7 +182806,6 @@ name: regulation of adenosine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032245 ! regulation of purine nucleoside transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032238 ! adenosine transport
relationship: regulates GO:0032238 ! adenosine transport
@@ -182645,7 +182821,6 @@ synonym: "downregulation of adenosine transport" EXACT []
synonym: "inhibition of adenosine transport" NARROW []
is_a: GO:0032247 ! negative regulation of purine nucleoside transport
is_a: GO:0032249 ! regulation of adenosine transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0032238 ! adenosine transport
relationship: negatively_regulates GO:0032238 ! adenosine transport
@@ -182662,7 +182837,6 @@ synonym: "up-regulation of adenosine transport" EXACT []
synonym: "upregulation of adenosine transport" EXACT []
is_a: GO:0032248 ! positive regulation of purine nucleoside transport
is_a: GO:0032249 ! regulation of adenosine transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0032238 ! adenosine transport
relationship: positively_regulates GO:0032238 ! adenosine transport
@@ -183312,7 +183486,7 @@ name: icosanoid secretion
namespace: biological_process
def: "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue." [GOC:mah]
synonym: "eicosanoid secretion" EXACT []
-is_a: GO:0046717 ! acid secretion
+is_a: GO:0046903 ! secretion
is_a: GO:0071715 ! icosanoid transport
[Term]
@@ -183372,7 +183546,6 @@ synonym: "molybdopterin cofactor synthesis" EXACT []
xref: MetaCyc:Molybdenum-Cofactor-Biosynthesis
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0043545 ! molybdopterin cofactor metabolic process
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
@@ -183390,7 +183563,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of the moly
is_a: GO:0043545 ! molybdopterin cofactor metabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
-is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
@@ -183417,7 +183589,6 @@ synonym: "Moco catabolism" BROAD []
synonym: "W-molybdopterin cofactor breakdown" EXACT []
synonym: "W-molybdopterin cofactor catabolism" EXACT []
synonym: "W-molybdopterin cofactor degradation" EXACT []
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0032325 ! molybdopterin cofactor catabolic process
is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process
@@ -183798,7 +183969,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123]
synonym: "response to E2 stimulus" EXACT []
synonym: "response to estradiol stimulus" EXACT [GOC:dos]
-is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -183844,7 +184014,6 @@ id: GO:0032361
name: pyridoxal phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah]
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042820 ! vitamin B6 catabolic process
is_a: GO:0042822 ! pyridoxal phosphate metabolic process
@@ -183869,7 +184038,6 @@ id: GO:0032363
name: FMN catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah]
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process
is_a: GO:0042728 ! flavin-containing compound catabolic process
@@ -185356,7 +185524,6 @@ id: GO:0032495
name: response to muramyl dipeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add]
-is_a: GO:0042493 ! response to drug
is_a: GO:1901652 ! response to peptide
[Term]
@@ -185400,7 +185567,6 @@ id: GO:0032500
name: muramyl dipeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl]
-is_a: GO:0008144 ! drug binding
is_a: GO:0042277 ! peptide binding
is_a: GO:0097367 ! carbohydrate derivative binding
@@ -185635,7 +185801,6 @@ name: response to retinoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl]
synonym: "response to vitamin A acid" EXACT []
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -185814,6 +185979,7 @@ synonym: "Srx1" RELATED [EC:1.8.98.2]
synonym: "sulphiredoxin activity" EXACT []
xref: EC:1.8.98.2
xref: MetaCyc:1.8.98.2-RXN
+xref: RHEA:17545
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors
@@ -186044,7 +186210,6 @@ name: response to progesterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl]
synonym: "response to progesterone stimulus" EXACT [GOC:dos]
-is_a: GO:0042493 ! response to drug
is_a: GO:0048545 ! response to steroid hormone
is_a: GO:1901654 ! response to ketone
@@ -186070,7 +186235,6 @@ name: response to phylloquinone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl]
synonym: "response to vitamin K1" EXACT []
-is_a: GO:0033273 ! response to vitamin
is_a: GO:1901654 ! response to ketone
[Term]
@@ -186082,6 +186246,7 @@ def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction driv
synonym: "5' to 3' RNA helicase activity" EXACT []
synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT []
synonym: "ATP-dependent 5'-3' RNA helicase activity" EXACT []
+xref: Reactome:R-HSA-9682695 "nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template"
is_a: GO:0003724 ! RNA helicase activity
[Term]
@@ -186333,8 +186498,21 @@ is_a: GO:0001816 ! cytokine production
id: GO:0032603
name: fractalkine production
namespace: biological_process
-def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
+alt_id: GO:0050751
+alt_id: GO:0050754
+def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:12729461]
+synonym: "ABCD-3 production" EXACT []
+synonym: "CX3C membrane-anchored chemokine production" EXACT []
+synonym: "CX3CL1 production" EXACT []
+synonym: "fractalkine biosynthetic process" NARROW []
+synonym: "positive regulation of CX3CL1 biosynthesis" NARROW []
+synonym: "positive regulation of fractalkine biosynthesis" NARROW []
+synonym: "positive regulation of fractalkine biosynthetic process" NARROW []
+synonym: "positive regulation of fractalkine formation" NARROW []
+synonym: "positive regulation of fractalkine synthesis" NARROW []
+synonym: "stimulation of fractalkine biosynthetic process" NARROW []
is_a: GO:0032602 ! chemokine production
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19254 xsd:anyURI
[Term]
id: GO:0032604
@@ -186356,35 +186534,49 @@ is_a: GO:0001816 ! cytokine production
id: GO:0032606
name: type I interferon production
namespace: biological_process
+alt_id: GO:0045351
def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "interferon type I production" EXACT []
synonym: "type I IFN production" EXACT []
+synonym: "type I interferon biosynthetic process" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032607
name: interferon-alpha production
namespace: biological_process
-def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
+alt_id: GO:0045349
+alt_id: GO:0072642
+def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383]
synonym: "IFN-alpha production" EXACT [GOC:mah]
synonym: "IFNA production" EXACT [GOC:mah]
+synonym: "interferon-alpha biosynthetic process" NARROW []
+synonym: "interferon-alpha secretion" NARROW []
is_a: GO:0032606 ! type I interferon production
[Term]
id: GO:0032608
name: interferon-beta production
namespace: biological_process
-def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
+alt_id: GO:0035546
+alt_id: GO:0045350
+def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383]
synonym: "IFN-beta production" EXACT []
synonym: "IFNB production" EXACT [GOC:mah]
+synonym: "interferon-beta biosynthetic process" NARROW []
+synonym: "interferon-beta secretion" NARROW []
is_a: GO:0032606 ! type I interferon production
[Term]
id: GO:0032609
name: interferon-gamma production
namespace: biological_process
-def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
+alt_id: GO:0042095
+alt_id: GO:0072643
+def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383]
synonym: "IFNG production" EXACT [GOC:mah]
+synonym: "interferon-gamma biosynthetic process" NARROW []
+synonym: "interferon-gamma secretion" NARROW []
synonym: "type II IFN production" BROAD [GOC:mah]
synonym: "type II interferon production" BROAD []
is_a: GO:0001816 ! cytokine production
@@ -186393,232 +186585,378 @@ is_a: GO:0001816 ! cytokine production
id: GO:0032610
name: interleukin-1 alpha production
namespace: biological_process
+alt_id: GO:0050703
+alt_id: GO:0050719
def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-1 alpha production" EXACT []
+synonym: "interleukin-1 alpha biosynthetic process" NARROW []
+synonym: "interleukin-1 alpha secretion" NARROW []
is_a: GO:0032612 ! interleukin-1 production
[Term]
id: GO:0032611
name: interleukin-1 beta production
namespace: biological_process
+alt_id: GO:0050702
+alt_id: GO:0050720
def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-1 beta production" EXACT []
+synonym: "interleukin-1 beta biosynthetic process" NARROW []
+synonym: "interleukin-1 beta secretion" NARROW []
is_a: GO:0032612 ! interleukin-1 production
[Term]
id: GO:0032612
name: interleukin-1 production
namespace: biological_process
+alt_id: GO:0042222
+alt_id: GO:0050701
def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-1 production" EXACT []
+synonym: "interleukin-1 biosynthetic process" NARROW []
+synonym: "interleukin-1 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032613
name: interleukin-10 production
namespace: biological_process
+alt_id: GO:0042091
+alt_id: GO:0072608
def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-10 production" EXACT []
+synonym: "interleukin-10 biosynthetic process" NARROW []
+synonym: "interleukin-10 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032614
name: interleukin-11 production
namespace: biological_process
+alt_id: GO:0042230
+alt_id: GO:0072609
def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-11 production" EXACT []
+synonym: "interleukin-11 biosynthetic process" NARROW []
+synonym: "interleukin-11 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032615
name: interleukin-12 production
namespace: biological_process
+alt_id: GO:0042090
+alt_id: GO:0072610
def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
+synonym: "CLMF production" NARROW [GOC:BHF]
synonym: "IL-12 production" EXACT []
+synonym: "interleukin-12 biosynthetic process" NARROW []
+synonym: "interleukin-12 secretion" NARROW []
+synonym: "NKSF production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032616
name: interleukin-13 production
namespace: biological_process
+alt_id: GO:0042231
+alt_id: GO:0072611
def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-13 production" EXACT []
+synonym: "interleukin-13 biosynthetic process" NARROW []
+synonym: "interleukin-13 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032617
name: interleukin-14 production
namespace: biological_process
+alt_id: GO:0042232
+alt_id: GO:0072612
def: "The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-14 production" EXACT []
+synonym: "interleukin-14 biosynthetic process" NARROW []
+synonym: "interleukin-14 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032618
name: interleukin-15 production
namespace: biological_process
+alt_id: GO:0042233
+alt_id: GO:0072613
def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-15 production" EXACT []
+synonym: "interleukin-15 biosynthetic process" NARROW []
+synonym: "interleukin-15 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032619
name: interleukin-16 production
namespace: biological_process
+alt_id: GO:0042234
+alt_id: GO:0072614
def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-16 production" EXACT []
+synonym: "interleukin-16 biosynthetic process" NARROW []
+synonym: "interleukin-16 secretion" NARROW []
+synonym: "LCF production" NARROW [GOC:BHF]
+synonym: "pro-interleukin-16 production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032620
name: interleukin-17 production
namespace: biological_process
-def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, PR:000001092, Wikipedia:Interleukin_17]
+alt_id: GO:0042235
+alt_id: GO:0072615
+def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, Wikipedia:Interleukin_17]
+synonym: "CTLA-8 production" EXACT [GOC:BHF]
+synonym: "Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:BHF]
synonym: "IL-17 production" EXACT []
+synonym: "interleukin-17 biosynthetic process" NARROW []
+synonym: "interleukin-17 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032621
name: interleukin-18 production
namespace: biological_process
+alt_id: GO:0042241
+alt_id: GO:0072616
def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
+synonym: "IGIF production" EXACT [GOC:BHF]
synonym: "IL-18 production" EXACT []
+synonym: "IL1F4 production" NARROW [GOC:BHF]
+synonym: "interleukin-18 biosynthetic process" NARROW []
+synonym: "interleukin-18 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032622
name: interleukin-19 production
namespace: biological_process
+alt_id: GO:0042236
+alt_id: GO:0072617
def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-19 production" EXACT []
+synonym: "IL-19 secretion" NARROW [GOC:BHF]
+synonym: "interleukin-19 biosynthetic process" NARROW []
+synonym: "interleukin-19 secretion" NARROW []
+synonym: "ZMDA1 secretion" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032623
name: interleukin-2 production
namespace: biological_process
+alt_id: GO:0042094
+alt_id: GO:0070970
def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-2 production" EXACT []
+synonym: "interleukin-2 biosynthetic process" NARROW []
+synonym: "interleukin-2 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032624
name: interleukin-20 production
namespace: biological_process
+alt_id: GO:0042237
+alt_id: GO:0072618
def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-20 production" EXACT []
+synonym: "interleukin-20 biosynthetic process" NARROW []
+synonym: "interleukin-20 secretion" NARROW []
+synonym: "ZCYTO10 production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032625
name: interleukin-21 production
namespace: biological_process
+alt_id: GO:0042238
+alt_id: GO:0072619
def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-21 production" EXACT []
+synonym: "interleukin-21 biosynthetic process" NARROW []
+synonym: "interleukin-21 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032626
name: interleukin-22 production
namespace: biological_process
+alt_id: GO:0042239
+alt_id: GO:0072620
def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-22 production" EXACT []
+synonym: "IL22 production" EXACT [GOC:BHF]
+synonym: "ILTIF production" EXACT [GOC:BHF]
+synonym: "interleukin-22 biosynthetic process" NARROW []
+synonym: "interleukin-22 secretion" NARROW []
+synonym: "ZCYTO18 production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032627
name: interleukin-23 production
namespace: biological_process
+alt_id: GO:0042240
+alt_id: GO:0072621
def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-23 production" EXACT []
+synonym: "interleukin-23 biosynthetic process" NARROW []
+synonym: "interleukin-23 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032628
name: interleukin-24 production
namespace: biological_process
+alt_id: GO:0045524
+alt_id: GO:0072622
def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-24 production" EXACT []
+synonym: "interleukin-24 biosynthetic process" NARROW []
+synonym: "interleukin-24 secretion" NARROW []
+synonym: "MDA7 production" NARROW [GOC:BHF]
+synonym: "ST16 production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032629
name: interleukin-25 production
namespace: biological_process
+alt_id: GO:0045525
+alt_id: GO:0072623
def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-25 production" EXACT []
+synonym: "IL-25 secretion" NARROW [GOC:BHF]
+synonym: "IL17E secretion" NARROW [GOC:BHF]
+synonym: "interleukin-25 anabolism" NARROW []
+synonym: "interleukin-25 biosynthesis" NARROW []
+synonym: "interleukin-25 biosynthetic process" NARROW []
+synonym: "interleukin-25 formation" NARROW []
+synonym: "interleukin-25 secretion" NARROW []
+synonym: "interleukin-25 synthesis" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032630
name: interleukin-26 production
namespace: biological_process
+alt_id: GO:0045526
+alt_id: GO:0072624
def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
+synonym: "AK155 secretion" NARROW [GOC:BHF]
synonym: "IL-26 production" EXACT []
+synonym: "interleukin-26 anabolism" NARROW []
+synonym: "interleukin-26 biosynthesis" NARROW []
+synonym: "interleukin-26 biosynthetic process" NARROW []
+synonym: "interleukin-26 formation" NARROW []
+synonym: "interleukin-26 secretion" NARROW []
+synonym: "interleukin-26 synthesis" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032631
name: interleukin-27 production
namespace: biological_process
+alt_id: GO:0045527
+alt_id: GO:0072625
def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-27 production" EXACT []
+synonym: "interleukin-27 biosynthetic process" NARROW []
+synonym: "interleukin-27 formation" NARROW []
+synonym: "interleukin-27 secretion" NARROW []
+synonym: "interleukin-27 synthesis" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032632
name: interleukin-3 production
namespace: biological_process
+alt_id: GO:0042223
+alt_id: GO:0072601
def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-3 production" EXACT []
+synonym: "interleukin-3 biosynthetic process" NARROW []
+synonym: "interleukin-3 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032633
name: interleukin-4 production
namespace: biological_process
+alt_id: GO:0042097
+alt_id: GO:0042224
+alt_id: GO:0072602
def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-4 production" EXACT []
+synonym: "interleukin-4 biosynthetic process" NARROW []
+synonym: "interleukin-4 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032634
name: interleukin-5 production
namespace: biological_process
+alt_id: GO:0042225
+alt_id: GO:0072603
def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-5 production" EXACT []
+synonym: "interleukin-5 biosynthetic process" NARROW []
+synonym: "interleukin-5 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032635
name: interleukin-6 production
namespace: biological_process
+alt_id: GO:0042226
+alt_id: GO:0072604
def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-6 production" EXACT []
+synonym: "interleukin-6 biosynthetic process" NARROW []
+synonym: "interleukin-6 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032636
name: interleukin-7 production
namespace: biological_process
+alt_id: GO:0042227
+alt_id: GO:0072605
def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-7 production" EXACT []
+synonym: "interleukin-7 biosynthetic process" NARROW []
+synonym: "interleukin-7 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032637
name: interleukin-8 production
namespace: biological_process
+alt_id: GO:0042228
+alt_id: GO:0072606
def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-8 production" EXACT []
+synonym: "interleukin-8 biosynthetic process" NARROW []
+synonym: "interleukin-8 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
id: GO:0032638
name: interleukin-9 production
namespace: biological_process
+alt_id: GO:0042229
+alt_id: GO:0072607
def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-9 production" EXACT []
+synonym: "interleukin-9 biosynthetic process" NARROW []
+synonym: "interleukin-9 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
@@ -186664,8 +187002,10 @@ relationship: regulates GO:0032602 ! chemokine production
id: GO:0032643
name: regulation of connective tissue growth factor production
namespace: biological_process
+alt_id: GO:0045420
def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "regulation of CCN2 production" EXACT []
+synonym: "regulation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "regulation of CTGF production" EXACT []
synonym: "regulation of Fisp12 production" EXACT []
synonym: "regulation of Hcs24 production" EXACT []
@@ -186680,11 +187020,16 @@ relationship: regulates GO:0032601 ! connective tissue growth factor production
id: GO:0032644
name: regulation of fractalkine production
namespace: biological_process
+alt_id: GO:0050752
def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah]
+synonym: "regulation of CX3CL1 biosynthesis" NARROW []
+synonym: "regulation of CX3CL1 production" NARROW []
+synonym: "regulation of fractalkine biosynthetic process" NARROW []
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032603 ! fractalkine production
relationship: regulates GO:0032603 ! fractalkine production
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19254 xsd:anyURI
[Term]
id: GO:0032645
@@ -186712,7 +187057,11 @@ relationship: regulates GO:0032605 ! hepatocyte growth factor production
id: GO:0032647
name: regulation of interferon-alpha production
namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah]
+alt_id: GO:0045354
+alt_id: GO:1902739
+def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383]
+synonym: "regulation of interferon-alpha biosynthetic process" NARROW []
+synonym: "regulation of interferon-alpha secretion" NARROW []
is_a: GO:0032479 ! regulation of type I interferon production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032607 ! interferon-alpha production
@@ -186722,8 +187071,12 @@ relationship: regulates GO:0032607 ! interferon-alpha production
id: GO:0032648
name: regulation of interferon-beta production
namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah]
+alt_id: GO:0035547
+alt_id: GO:0045357
+def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383]
synonym: "regulation of IFN-beta production" EXACT []
+synonym: "regulation of interferon-beta biosynthetic process" NARROW []
+synonym: "regulation of interferon-beta secretion" NARROW []
is_a: GO:0032479 ! regulation of type I interferon production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032608 ! interferon-beta production
@@ -186733,7 +187086,11 @@ relationship: regulates GO:0032608 ! interferon-beta production
id: GO:0032649
name: regulation of interferon-gamma production
namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
+alt_id: GO:0045072
+alt_id: GO:1902713
+def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383]
+synonym: "regulation of interferon-gamma biosynthetic process" NARROW []
+synonym: "regulation of interferon-gamma secretion" NARROW []
synonym: "regulation of type II interferon production" BROAD []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
@@ -186744,8 +187101,12 @@ relationship: regulates GO:0032609 ! interferon-gamma production
id: GO:0032650
name: regulation of interleukin-1 alpha production
namespace: biological_process
+alt_id: GO:0050705
+alt_id: GO:0050721
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "regulation of IL-1 alpha production" EXACT []
+synonym: "regulation of interleukin-1 alpha biosynthetic process" NARROW []
+synonym: "regulation of interleukin-1 alpha secretion" NARROW []
is_a: GO:0032652 ! regulation of interleukin-1 production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032610 ! interleukin-1 alpha production
@@ -186755,8 +187116,12 @@ relationship: regulates GO:0032610 ! interleukin-1 alpha production
id: GO:0032651
name: regulation of interleukin-1 beta production
namespace: biological_process
+alt_id: GO:0050706
+alt_id: GO:0050722
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "regulation of IL-1 beta production" EXACT []
+synonym: "regulation of interleukin-1 beta biosynthetic process" NARROW []
+synonym: "regulation of interleukin-1 beta secretion" NARROW []
is_a: GO:0032652 ! regulation of interleukin-1 production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032611 ! interleukin-1 beta production
@@ -186766,8 +187131,12 @@ relationship: regulates GO:0032611 ! interleukin-1 beta production
id: GO:0032652
name: regulation of interleukin-1 production
namespace: biological_process
+alt_id: GO:0045360
+alt_id: GO:0050704
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "regulation of IL-1 production" EXACT []
+synonym: "regulation of interleukin-1 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-1 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032612 ! interleukin-1 production
@@ -186777,8 +187146,12 @@ relationship: regulates GO:0032612 ! interleukin-1 production
id: GO:0032653
name: regulation of interleukin-10 production
namespace: biological_process
+alt_id: GO:0045074
+alt_id: GO:2001179
def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "regulation of IL-10 production" EXACT []
+synonym: "regulation of interleukin-10 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-10 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032613 ! interleukin-10 production
@@ -186788,8 +187161,12 @@ relationship: regulates GO:0032613 ! interleukin-10 production
id: GO:0032654
name: regulation of interleukin-11 production
namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
+alt_id: GO:0045363
+alt_id: GO:0150169
+def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah, PMID:29286137]
synonym: "regulation of IL-11 production" EXACT []
+synonym: "regulation of interleukin-11 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-11 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032614 ! interleukin-11 production
@@ -186799,8 +187176,14 @@ relationship: regulates GO:0032614 ! interleukin-11 production
id: GO:0032655
name: regulation of interleukin-12 production
namespace: biological_process
+alt_id: GO:0045075
+alt_id: GO:2001182
def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
+synonym: "regulation of CLMF production" RELATED [GOC:obol]
synonym: "regulation of IL-12 production" EXACT []
+synonym: "regulation of interleukin-12 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-12 secretion" NARROW []
+synonym: "regulation of NKSF production" RELATED [GOC:obol]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032615 ! interleukin-12 production
@@ -186810,8 +187193,12 @@ relationship: regulates GO:0032615 ! interleukin-12 production
id: GO:0032656
name: regulation of interleukin-13 production
namespace: biological_process
+alt_id: GO:0045366
+alt_id: GO:2000665
def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "regulation of IL-13 production" EXACT []
+synonym: "regulation of interleukin-13 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-13 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032616 ! interleukin-13 production
@@ -186821,8 +187208,10 @@ relationship: regulates GO:0032616 ! interleukin-13 production
id: GO:0032657
name: regulation of interleukin-14 production
namespace: biological_process
+alt_id: GO:0045369
def: "Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
synonym: "regulation of IL-14 production" EXACT []
+synonym: "regulation of interleukin-14 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032617 ! interleukin-14 production
@@ -186832,8 +187221,10 @@ relationship: regulates GO:0032617 ! interleukin-14 production
id: GO:0032658
name: regulation of interleukin-15 production
namespace: biological_process
+alt_id: GO:0045372
def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "regulation of IL-15 production" EXACT []
+synonym: "regulation of interleukin-15 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032618 ! interleukin-15 production
@@ -186843,8 +187234,10 @@ relationship: regulates GO:0032618 ! interleukin-15 production
id: GO:0032659
name: regulation of interleukin-16 production
namespace: biological_process
+alt_id: GO:0045375
def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "regulation of IL-16 production" EXACT []
+synonym: "regulation of interleukin-16 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032619 ! interleukin-16 production
@@ -186854,8 +187247,14 @@ relationship: regulates GO:0032619 ! interleukin-16 production
id: GO:0032660
name: regulation of interleukin-17 production
namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah]
+alt_id: GO:0045378
+alt_id: GO:1905076
+def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511]
+synonym: "regulation of CTLA-8 production" EXACT [GOC:TermGenie]
+synonym: "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT []
synonym: "regulation of IL-17 production" EXACT []
+synonym: "regulation of interleukin-17 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-17 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032620 ! interleukin-17 production
@@ -186865,8 +187264,12 @@ relationship: regulates GO:0032620 ! interleukin-17 production
id: GO:0032661
name: regulation of interleukin-18 production
namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
+alt_id: GO:0045381
+alt_id: GO:0150120
+def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah, PMID:23710316]
synonym: "regulation of IL-18 production" EXACT []
+synonym: "regulation of interleukin-18 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-18 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032621 ! interleukin-18 production
@@ -186876,8 +187279,10 @@ relationship: regulates GO:0032621 ! interleukin-18 production
id: GO:0032662
name: regulation of interleukin-19 production
namespace: biological_process
+alt_id: GO:0045384
def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "regulation of IL-19 production" EXACT []
+synonym: "regulation of interleukin-19 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032622 ! interleukin-19 production
@@ -186887,8 +187292,12 @@ relationship: regulates GO:0032622 ! interleukin-19 production
id: GO:0032663
name: regulation of interleukin-2 production
namespace: biological_process
+alt_id: GO:0045076
+alt_id: GO:1900040
def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "regulation of IL-2 production" EXACT []
+synonym: "regulation of interleukin-2 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-2 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032623 ! interleukin-2 production
@@ -186898,8 +187307,10 @@ relationship: regulates GO:0032623 ! interleukin-2 production
id: GO:0032664
name: regulation of interleukin-20 production
namespace: biological_process
+alt_id: GO:0045387
def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "regulation of IL-20 production" EXACT []
+synonym: "regulation of interleukin-20 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032624 ! interleukin-20 production
@@ -186909,8 +187320,10 @@ relationship: regulates GO:0032624 ! interleukin-20 production
id: GO:0032665
name: regulation of interleukin-21 production
namespace: biological_process
+alt_id: GO:0045390
def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "regulation of IL-21 production" EXACT []
+synonym: "regulation of interleukin-21 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032625 ! interleukin-21 production
@@ -186920,8 +187333,10 @@ relationship: regulates GO:0032625 ! interleukin-21 production
id: GO:0032666
name: regulation of interleukin-22 production
namespace: biological_process
+alt_id: GO:0045393
def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "regulation of IL-22 production" EXACT []
+synonym: "regulation of interleukin-22 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032626 ! interleukin-22 production
@@ -186931,8 +187346,15 @@ relationship: regulates GO:0032626 ! interleukin-22 production
id: GO:0032667
name: regulation of interleukin-23 production
namespace: biological_process
+alt_id: GO:0045396
def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
+synonym: "regulation of IL-23 biosynthetic process" EXACT []
synonym: "regulation of IL-23 production" EXACT []
+synonym: "regulation of interleukin-23 anabolism" NARROW []
+synonym: "regulation of interleukin-23 biosynthesis" NARROW []
+synonym: "regulation of interleukin-23 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-23 formation" NARROW []
+synonym: "regulation of interleukin-23 synthesis" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032627 ! interleukin-23 production
@@ -186942,8 +187364,10 @@ relationship: regulates GO:0032627 ! interleukin-23 production
id: GO:0032668
name: regulation of interleukin-24 production
namespace: biological_process
+alt_id: GO:0045528
def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "regulation of IL-24 production" EXACT []
+synonym: "regulation of interleukin-24 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032628 ! interleukin-24 production
@@ -186953,19 +187377,27 @@ relationship: regulates GO:0032628 ! interleukin-24 production
id: GO:0032669
name: regulation of interleukin-25 production
namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
+alt_id: GO:0045529
+alt_id: GO:0150148
+def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah, PMID:27901018]
synonym: "regulation of IL-25 production" EXACT []
+synonym: "regulation of interleukin-25 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-25 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032629 ! interleukin-25 production
relationship: regulates GO:0032629 ! interleukin-25 production
+created_by: bc
+creation_date: 2019-12-09T16:51:07Z
[Term]
id: GO:0032670
name: regulation of interleukin-26 production
namespace: biological_process
+alt_id: GO:0045530
def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "regulation of IL-26 production" EXACT []
+synonym: "regulation of interleukin-26 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032630 ! interleukin-26 production
@@ -186975,8 +187407,12 @@ relationship: regulates GO:0032630 ! interleukin-26 production
id: GO:0032671
name: regulation of interleukin-27 production
namespace: biological_process
+alt_id: GO:0045531
def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "regulation of IL-27 production" EXACT []
+synonym: "regulation of interleukin-27 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-27 formation" NARROW []
+synonym: "regulation of interleukin-27 synthesis" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032631 ! interleukin-27 production
@@ -186986,8 +187422,10 @@ relationship: regulates GO:0032631 ! interleukin-27 production
id: GO:0032672
name: regulation of interleukin-3 production
namespace: biological_process
+alt_id: GO:0045399
def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "regulation of IL-3 production" EXACT []
+synonym: "regulation of interleukin-3 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032632 ! interleukin-3 production
@@ -186997,8 +187435,12 @@ relationship: regulates GO:0032632 ! interleukin-3 production
id: GO:0032673
name: regulation of interleukin-4 production
namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
+alt_id: GO:0045402
+alt_id: GO:0150133
+def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524]
synonym: "regulation of IL-4 production" EXACT []
+synonym: "regulation of interleukin-4 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-4 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032633 ! interleukin-4 production
@@ -187008,8 +187450,12 @@ relationship: regulates GO:0032633 ! interleukin-4 production
id: GO:0032674
name: regulation of interleukin-5 production
namespace: biological_process
+alt_id: GO:0045405
+alt_id: GO:2000662
def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "regulation of IL-5 production" EXACT []
+synonym: "regulation of interleukin-5 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-5 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032634 ! interleukin-5 production
@@ -187019,8 +187465,10 @@ relationship: regulates GO:0032634 ! interleukin-5 production
id: GO:0032675
name: regulation of interleukin-6 production
namespace: biological_process
+alt_id: GO:0045408
def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "regulation of IL-6 production" EXACT []
+synonym: "regulation of interleukin-6 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032635 ! interleukin-6 production
@@ -187030,8 +187478,12 @@ relationship: regulates GO:0032635 ! interleukin-6 production
id: GO:0032676
name: regulation of interleukin-7 production
namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
+alt_id: GO:0045411
+alt_id: GO:0150112
+def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah, PMID:25962782]
synonym: "regulation of IL-7 production" EXACT []
+synonym: "regulation of interleukin-7 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-7 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032636 ! interleukin-7 production
@@ -187041,8 +187493,12 @@ relationship: regulates GO:0032636 ! interleukin-7 production
id: GO:0032677
name: regulation of interleukin-8 production
namespace: biological_process
+alt_id: GO:0045414
+alt_id: GO:2000482
def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "regulation of IL-8 production" EXACT []
+synonym: "regulation of interleukin-8 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-8 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032637 ! interleukin-8 production
@@ -187052,8 +187508,10 @@ relationship: regulates GO:0032637 ! interleukin-8 production
id: GO:0032678
name: regulation of interleukin-9 production
namespace: biological_process
+alt_id: GO:0045417
def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "regulation of IL-9 production" EXACT []
+synonym: "regulation of interleukin-9 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0032638 ! interleukin-9 production
@@ -187116,12 +187574,14 @@ relationship: negatively_regulates GO:0032602 ! chemokine production
id: GO:0032683
name: negative regulation of connective tissue growth factor production
namespace: biological_process
+alt_id: GO:0045421
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "down regulation of connective tissue growth factor production" EXACT []
synonym: "down-regulation of connective tissue growth factor production" EXACT []
synonym: "downregulation of connective tissue growth factor production" EXACT []
synonym: "inhibition of connective tissue growth factor production" NARROW []
synonym: "negative regulation of CCN2 production" EXACT []
+synonym: "negative regulation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "negative regulation of CTGF production" EXACT []
synonym: "negative regulation of Fisp12 production" EXACT []
synonym: "negative regulation of Hcs24 production" EXACT []
@@ -187137,16 +187597,21 @@ relationship: negatively_regulates GO:0032601 ! connective tissue growth factor
id: GO:0032684
name: negative regulation of fractalkine production
namespace: biological_process
+alt_id: GO:0050753
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah]
synonym: "down regulation of fractalkine production" EXACT []
synonym: "down-regulation of fractalkine production" EXACT []
synonym: "downregulation of fractalkine production" EXACT []
synonym: "inhibition of fractalkine production" NARROW []
+synonym: "negative regulation of CX3CL1 biosynthesis" NARROW []
+synonym: "negative regulation of CX3CL1 production" EXACT []
+synonym: "negative regulation of fractalkine biosynthetic process" NARROW []
is_a: GO:0032644 ! regulation of fractalkine production
is_a: GO:0032682 ! negative regulation of chemokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0032603 ! fractalkine production
relationship: negatively_regulates GO:0032603 ! fractalkine production
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19254 xsd:anyURI
[Term]
id: GO:0032685
@@ -187184,11 +187649,15 @@ relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor product
id: GO:0032687
name: negative regulation of interferon-alpha production
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah]
+alt_id: GO:0045355
+alt_id: GO:1902740
+def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383]
synonym: "down regulation of interferon-alpha production" EXACT []
synonym: "down-regulation of interferon-alpha production" EXACT []
synonym: "downregulation of interferon-alpha production" EXACT []
synonym: "inhibition of interferon-alpha production" NARROW []
+synonym: "negative regulation of interferon-alpha biosynthetic process" NARROW []
+synonym: "negative regulation of interferon-alpha secretion" NARROW []
is_a: GO:0032480 ! negative regulation of type I interferon production
is_a: GO:0032647 ! regulation of interferon-alpha production
intersection_of: GO:0008150 ! biological_process
@@ -187199,12 +187668,16 @@ relationship: negatively_regulates GO:0032607 ! interferon-alpha production
id: GO:0032688
name: negative regulation of interferon-beta production
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah]
+alt_id: GO:0035548
+alt_id: GO:0045358
+def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383]
synonym: "down regulation of interferon-beta production" EXACT []
synonym: "down-regulation of interferon-beta production" EXACT []
synonym: "downregulation of interferon-beta production" EXACT []
synonym: "inhibition of interferon-beta production" NARROW []
synonym: "negative regulation of IFN-beta production" EXACT []
+synonym: "negative regulation of interferon-beta biosynthetic process" NARROW []
+synonym: "negative regulation of interferon-beta secretion" NARROW []
is_a: GO:0032480 ! negative regulation of type I interferon production
is_a: GO:0032648 ! regulation of interferon-beta production
intersection_of: GO:0008150 ! biological_process
@@ -187215,11 +187688,15 @@ relationship: negatively_regulates GO:0032608 ! interferon-beta production
id: GO:0032689
name: negative regulation of interferon-gamma production
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
+alt_id: GO:0045077
+alt_id: GO:1902714
+def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383]
synonym: "down regulation of interferon-gamma production" EXACT []
synonym: "down-regulation of interferon-gamma production" EXACT []
synonym: "downregulation of interferon-gamma production" EXACT []
synonym: "inhibition of interferon-gamma production" NARROW []
+synonym: "negative regulation of interferon-gamma biosynthetic process" NARROW []
+synonym: "negative regulation of interferon-gamma secretion" NARROW []
synonym: "negative regulation of type II interferon production" BROAD []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032649 ! regulation of interferon-gamma production
@@ -187231,12 +187708,16 @@ relationship: negatively_regulates GO:0032609 ! interferon-gamma production
id: GO:0032690
name: negative regulation of interleukin-1 alpha production
namespace: biological_process
+alt_id: GO:0050712
+alt_id: GO:0050723
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "down regulation of interleukin-1 alpha production" EXACT []
synonym: "down-regulation of interleukin-1 alpha production" EXACT []
synonym: "downregulation of interleukin-1 alpha production" EXACT []
synonym: "inhibition of interleukin-1 alpha production" NARROW []
synonym: "negative regulation of IL-1 alpha production" EXACT []
+synonym: "negative regulation of interleukin-1 alpha biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-1 alpha secretion" NARROW []
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0032692 ! negative regulation of interleukin-1 production
intersection_of: GO:0008150 ! biological_process
@@ -187247,12 +187728,16 @@ relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production
id: GO:0032691
name: negative regulation of interleukin-1 beta production
namespace: biological_process
+alt_id: GO:0050713
+alt_id: GO:0050724
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "down regulation of interleukin-1 beta production" EXACT []
synonym: "down-regulation of interleukin-1 beta production" EXACT []
synonym: "downregulation of interleukin-1 beta production" EXACT []
synonym: "inhibition of interleukin-1 beta production" NARROW []
synonym: "negative regulation of IL-1 beta production" EXACT []
+synonym: "negative regulation of interleukin-1 beta biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-1 beta secretion" NARROW []
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0032692 ! negative regulation of interleukin-1 production
intersection_of: GO:0008150 ! biological_process
@@ -187263,12 +187748,16 @@ relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production
id: GO:0032692
name: negative regulation of interleukin-1 production
namespace: biological_process
+alt_id: GO:0045361
+alt_id: GO:0050711
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "down regulation of interleukin-1 production" EXACT []
synonym: "down-regulation of interleukin-1 production" EXACT []
synonym: "downregulation of interleukin-1 production" EXACT []
synonym: "inhibition of interleukin-1 production" NARROW []
synonym: "negative regulation of IL-1 production" EXACT []
+synonym: "negative regulation of interleukin-1 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-1 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032652 ! regulation of interleukin-1 production
intersection_of: GO:0008150 ! biological_process
@@ -187279,12 +187768,16 @@ relationship: negatively_regulates GO:0032612 ! interleukin-1 production
id: GO:0032693
name: negative regulation of interleukin-10 production
namespace: biological_process
+alt_id: GO:0045081
+alt_id: GO:2001180
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "down regulation of interleukin-10 production" EXACT []
synonym: "down-regulation of interleukin-10 production" EXACT []
synonym: "downregulation of interleukin-10 production" EXACT []
synonym: "inhibition of interleukin-10 production" NARROW []
synonym: "negative regulation of IL-10 production" EXACT []
+synonym: "negative regulation of interleukin-10 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-10 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032653 ! regulation of interleukin-10 production
intersection_of: GO:0008150 ! biological_process
@@ -187295,12 +187788,16 @@ relationship: negatively_regulates GO:0032613 ! interleukin-10 production
id: GO:0032694
name: negative regulation of interleukin-11 production
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
+alt_id: GO:0045364
+alt_id: GO:0150170
+def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah, PMID:29286137]
synonym: "down regulation of interleukin-11 production" EXACT []
synonym: "down-regulation of interleukin-11 production" EXACT []
synonym: "downregulation of interleukin-11 production" EXACT []
synonym: "inhibition of interleukin-11 production" NARROW []
synonym: "negative regulation of IL-11 production" EXACT []
+synonym: "negative regulation of interleukin-11 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-11 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032654 ! regulation of interleukin-11 production
intersection_of: GO:0008150 ! biological_process
@@ -187311,12 +187808,18 @@ relationship: negatively_regulates GO:0032614 ! interleukin-11 production
id: GO:0032695
name: negative regulation of interleukin-12 production
namespace: biological_process
+alt_id: GO:0045083
+alt_id: GO:2001183
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "down regulation of interleukin-12 production" EXACT []
synonym: "down-regulation of interleukin-12 production" EXACT []
synonym: "downregulation of interleukin-12 production" EXACT []
synonym: "inhibition of interleukin-12 production" NARROW []
+synonym: "negative regulation of CLMF production" RELATED [GOC:obol]
synonym: "negative regulation of IL-12 production" EXACT []
+synonym: "negative regulation of interleukin-12 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-12 secretion" NARROW []
+synonym: "negative regulation of NKSF production" RELATED [GOC:obol]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032655 ! regulation of interleukin-12 production
intersection_of: GO:0008150 ! biological_process
@@ -187327,12 +187830,16 @@ relationship: negatively_regulates GO:0032615 ! interleukin-12 production
id: GO:0032696
name: negative regulation of interleukin-13 production
namespace: biological_process
+alt_id: GO:0045367
+alt_id: GO:2000666
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "down regulation of interleukin-13 production" EXACT []
synonym: "down-regulation of interleukin-13 production" EXACT []
synonym: "downregulation of interleukin-13 production" EXACT []
synonym: "inhibition of interleukin-13 production" NARROW []
synonym: "negative regulation of IL-13 production" EXACT []
+synonym: "negative regulation of interleukin-13 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-13 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032656 ! regulation of interleukin-13 production
intersection_of: GO:0008150 ! biological_process
@@ -187343,12 +187850,14 @@ relationship: negatively_regulates GO:0032616 ! interleukin-13 production
id: GO:0032697
name: negative regulation of interleukin-14 production
namespace: biological_process
+alt_id: GO:0045370
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
synonym: "down regulation of interleukin-14 production" EXACT []
synonym: "down-regulation of interleukin-14 production" EXACT []
synonym: "downregulation of interleukin-14 production" EXACT []
synonym: "inhibition of interleukin-14 production" NARROW []
synonym: "negative regulation of IL-14 production" EXACT []
+synonym: "negative regulation of interleukin-14 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032657 ! regulation of interleukin-14 production
intersection_of: GO:0008150 ! biological_process
@@ -187359,12 +187868,14 @@ relationship: negatively_regulates GO:0032617 ! interleukin-14 production
id: GO:0032698
name: negative regulation of interleukin-15 production
namespace: biological_process
+alt_id: GO:0045373
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "down regulation of interleukin-15 production" EXACT []
synonym: "down-regulation of interleukin-15 production" EXACT []
synonym: "downregulation of interleukin-15 production" EXACT []
synonym: "inhibition of interleukin-15 production" NARROW []
synonym: "negative regulation of IL-15 production" EXACT []
+synonym: "negative regulation of interleukin-15 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032658 ! regulation of interleukin-15 production
intersection_of: GO:0008150 ! biological_process
@@ -187375,12 +187886,14 @@ relationship: negatively_regulates GO:0032618 ! interleukin-15 production
id: GO:0032699
name: negative regulation of interleukin-16 production
namespace: biological_process
+alt_id: GO:0045376
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "down regulation of interleukin-16 production" EXACT []
synonym: "down-regulation of interleukin-16 production" EXACT []
synonym: "downregulation of interleukin-16 production" EXACT []
synonym: "inhibition of interleukin-16 production" NARROW []
synonym: "negative regulation of IL-16 production" EXACT []
+synonym: "negative regulation of interleukin-16 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032659 ! regulation of interleukin-16 production
intersection_of: GO:0008150 ! biological_process
@@ -187391,12 +187904,17 @@ relationship: negatively_regulates GO:0032619 ! interleukin-16 production
id: GO:0032700
name: negative regulation of interleukin-17 production
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah]
+alt_id: GO:0045379
+alt_id: GO:1905077
+def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511]
synonym: "down regulation of interleukin-17 production" EXACT []
-synonym: "down-regulation of interleukin-17 production" EXACT []
synonym: "downregulation of interleukin-17 production" EXACT []
synonym: "inhibition of interleukin-17 production" NARROW []
+synonym: "negative regulation of CTLA-8 production" NARROW [GOC:TermGenie]
+synonym: "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of IL-17 production" EXACT []
+synonym: "negative regulation of interleukin-17 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-17 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032660 ! regulation of interleukin-17 production
intersection_of: GO:0008150 ! biological_process
@@ -187407,12 +187925,16 @@ relationship: negatively_regulates GO:0032620 ! interleukin-17 production
id: GO:0032701
name: negative regulation of interleukin-18 production
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
+alt_id: GO:0045382
+alt_id: GO:0150121
+def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah, PMID:23710316]
synonym: "down regulation of interleukin-18 production" EXACT []
synonym: "down-regulation of interleukin-18 production" EXACT []
synonym: "downregulation of interleukin-18 production" EXACT []
synonym: "inhibition of interleukin-18 production" NARROW []
synonym: "negative regulation of IL-18 production" EXACT []
+synonym: "negative regulation of interleukin-18 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-18 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032661 ! regulation of interleukin-18 production
intersection_of: GO:0008150 ! biological_process
@@ -187423,12 +187945,14 @@ relationship: negatively_regulates GO:0032621 ! interleukin-18 production
id: GO:0032702
name: negative regulation of interleukin-19 production
namespace: biological_process
+alt_id: GO:0045385
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "down regulation of interleukin-19 production" EXACT []
synonym: "down-regulation of interleukin-19 production" EXACT []
synonym: "downregulation of interleukin-19 production" EXACT []
synonym: "inhibition of interleukin-19 production" NARROW []
synonym: "negative regulation of IL-19 production" EXACT []
+synonym: "negative regulation of interleukin-19 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032662 ! regulation of interleukin-19 production
intersection_of: GO:0008150 ! biological_process
@@ -187439,12 +187963,16 @@ relationship: negatively_regulates GO:0032622 ! interleukin-19 production
id: GO:0032703
name: negative regulation of interleukin-2 production
namespace: biological_process
+alt_id: GO:0045085
+alt_id: GO:1900041
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "down regulation of interleukin-2 production" EXACT []
synonym: "down-regulation of interleukin-2 production" EXACT []
synonym: "downregulation of interleukin-2 production" EXACT []
synonym: "inhibition of interleukin-2 production" NARROW []
synonym: "negative regulation of IL-2 production" EXACT []
+synonym: "negative regulation of interleukin-2 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-2 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032663 ! regulation of interleukin-2 production
intersection_of: GO:0008150 ! biological_process
@@ -187455,12 +187983,14 @@ relationship: negatively_regulates GO:0032623 ! interleukin-2 production
id: GO:0032704
name: negative regulation of interleukin-20 production
namespace: biological_process
+alt_id: GO:0045388
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "down regulation of interleukin-20 production" EXACT []
synonym: "down-regulation of interleukin-20 production" EXACT []
synonym: "downregulation of interleukin-20 production" EXACT []
synonym: "inhibition of interleukin-20 production" NARROW []
synonym: "negative regulation of IL-20 production" EXACT []
+synonym: "negative regulation of interleukin-20 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032664 ! regulation of interleukin-20 production
intersection_of: GO:0008150 ! biological_process
@@ -187471,12 +188001,12 @@ relationship: negatively_regulates GO:0032624 ! interleukin-20 production
id: GO:0032705
name: negative regulation of interleukin-21 production
namespace: biological_process
+alt_id: GO:0045391
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "down regulation of interleukin-21 production" EXACT []
synonym: "down-regulation of interleukin-21 production" EXACT []
synonym: "downregulation of interleukin-21 production" EXACT []
-synonym: "inhibition of interleukin-21 production" NARROW []
-synonym: "negative regulation of IL-21 production" EXACT []
+synonym: "negative regulation of interleukin-21 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032665 ! regulation of interleukin-21 production
intersection_of: GO:0008150 ! biological_process
@@ -187487,12 +188017,14 @@ relationship: negatively_regulates GO:0032625 ! interleukin-21 production
id: GO:0032706
name: negative regulation of interleukin-22 production
namespace: biological_process
+alt_id: GO:0045394
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "down regulation of interleukin-22 production" EXACT []
synonym: "down-regulation of interleukin-22 production" EXACT []
synonym: "downregulation of interleukin-22 production" EXACT []
synonym: "inhibition of interleukin-22 production" NARROW []
synonym: "negative regulation of IL-22 production" EXACT []
+synonym: "negative regulation of interleukin-22 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032666 ! regulation of interleukin-22 production
intersection_of: GO:0008150 ! biological_process
@@ -187503,12 +188035,14 @@ relationship: negatively_regulates GO:0032626 ! interleukin-22 production
id: GO:0032707
name: negative regulation of interleukin-23 production
namespace: biological_process
+alt_id: GO:0045397
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "down regulation of interleukin-23 production" EXACT []
synonym: "down-regulation of interleukin-23 production" EXACT []
synonym: "downregulation of interleukin-23 production" EXACT []
synonym: "inhibition of interleukin-23 production" NARROW []
synonym: "negative regulation of IL-23 production" EXACT []
+synonym: "negative regulation of interleukin-23 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032667 ! regulation of interleukin-23 production
intersection_of: GO:0008150 ! biological_process
@@ -187519,12 +188053,14 @@ relationship: negatively_regulates GO:0032627 ! interleukin-23 production
id: GO:0032708
name: negative regulation of interleukin-24 production
namespace: biological_process
+alt_id: GO:0045532
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "down regulation of interleukin-24 production" EXACT []
synonym: "down-regulation of interleukin-24 production" EXACT []
synonym: "downregulation of interleukin-24 production" EXACT []
synonym: "inhibition of interleukin-24 production" NARROW []
synonym: "negative regulation of IL-24 production" EXACT []
+synonym: "negative regulation of interleukin-24 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032668 ! regulation of interleukin-24 production
intersection_of: GO:0008150 ! biological_process
@@ -187535,12 +188071,16 @@ relationship: negatively_regulates GO:0032628 ! interleukin-24 production
id: GO:0032709
name: negative regulation of interleukin-25 production
namespace: biological_process
+alt_id: GO:0045533
+alt_id: GO:0150149
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "down regulation of interleukin-25 production" EXACT []
synonym: "down-regulation of interleukin-25 production" EXACT []
synonym: "downregulation of interleukin-25 production" EXACT []
synonym: "inhibition of interleukin-25 production" NARROW []
synonym: "negative regulation of IL-25 production" EXACT []
+synonym: "negative regulation of interleukin-25 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-25 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032669 ! regulation of interleukin-25 production
intersection_of: GO:0008150 ! biological_process
@@ -187551,12 +188091,14 @@ relationship: negatively_regulates GO:0032629 ! interleukin-25 production
id: GO:0032710
name: negative regulation of interleukin-26 production
namespace: biological_process
+alt_id: GO:0045534
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "down regulation of interleukin-26 production" EXACT []
synonym: "down-regulation of interleukin-26 production" EXACT []
synonym: "downregulation of interleukin-26 production" EXACT []
synonym: "inhibition of interleukin-26 production" NARROW []
synonym: "negative regulation of IL-26 production" EXACT []
+synonym: "negative regulation of interleukin-26 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032670 ! regulation of interleukin-26 production
intersection_of: GO:0008150 ! biological_process
@@ -187567,12 +188109,14 @@ relationship: negatively_regulates GO:0032630 ! interleukin-26 production
id: GO:0032711
name: negative regulation of interleukin-27 production
namespace: biological_process
+alt_id: GO:0045535
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "down regulation of interleukin-27 production" EXACT []
synonym: "down-regulation of interleukin-27 production" EXACT []
synonym: "downregulation of interleukin-27 production" EXACT []
synonym: "inhibition of interleukin-27 production" NARROW []
synonym: "negative regulation of IL-27 production" EXACT []
+synonym: "negative regulation of interleukin-27 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032671 ! regulation of interleukin-27 production
intersection_of: GO:0008150 ! biological_process
@@ -187583,12 +188127,14 @@ relationship: negatively_regulates GO:0032631 ! interleukin-27 production
id: GO:0032712
name: negative regulation of interleukin-3 production
namespace: biological_process
+alt_id: GO:0045400
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "down regulation of interleukin-3 production" EXACT []
synonym: "down-regulation of interleukin-3 production" EXACT []
synonym: "downregulation of interleukin-3 production" EXACT []
synonym: "inhibition of interleukin-3 production" NARROW []
synonym: "negative regulation of IL-3 production" EXACT []
+synonym: "negative regulation of interleukin-3 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032672 ! regulation of interleukin-3 production
intersection_of: GO:0008150 ! biological_process
@@ -187599,28 +188145,37 @@ relationship: negatively_regulates GO:0032632 ! interleukin-3 production
id: GO:0032713
name: negative regulation of interleukin-4 production
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
+alt_id: GO:0045403
+alt_id: GO:0150134
+def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524]
synonym: "down regulation of interleukin-4 production" EXACT []
synonym: "down-regulation of interleukin-4 production" EXACT []
synonym: "downregulation of interleukin-4 production" EXACT []
synonym: "inhibition of interleukin-4 production" NARROW []
synonym: "negative regulation of IL-4 production" EXACT []
+synonym: "negative regulation of interleukin-4 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-4 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032673 ! regulation of interleukin-4 production
-intersection_of: GO:0008150 ! biological_process
+intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032633 ! interleukin-4 production
relationship: negatively_regulates GO:0032633 ! interleukin-4 production
+created_by: bc
[Term]
id: GO:0032714
name: negative regulation of interleukin-5 production
namespace: biological_process
+alt_id: GO:0045406
+alt_id: GO:2000663
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "down regulation of interleukin-5 production" EXACT []
synonym: "down-regulation of interleukin-5 production" EXACT []
synonym: "downregulation of interleukin-5 production" EXACT []
synonym: "inhibition of interleukin-5 production" NARROW []
synonym: "negative regulation of IL-5 production" EXACT []
+synonym: "negative regulation of interleukin-5 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-5 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032674 ! regulation of interleukin-5 production
intersection_of: GO:0008150 ! biological_process
@@ -187631,12 +188186,16 @@ relationship: negatively_regulates GO:0032634 ! interleukin-5 production
id: GO:0032715
name: negative regulation of interleukin-6 production
namespace: biological_process
+alt_id: GO:0045409
+alt_id: GO:1900165
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "down regulation of interleukin-6 production" EXACT []
synonym: "down-regulation of interleukin-6 production" EXACT []
synonym: "downregulation of interleukin-6 production" EXACT []
synonym: "inhibition of interleukin-6 production" NARROW []
synonym: "negative regulation of IL-6 production" EXACT []
+synonym: "negative regulation of interleukin-6 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-6 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032675 ! regulation of interleukin-6 production
intersection_of: GO:0008150 ! biological_process
@@ -187647,12 +188206,16 @@ relationship: negatively_regulates GO:0032635 ! interleukin-6 production
id: GO:0032716
name: negative regulation of interleukin-7 production
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
+alt_id: GO:0045412
+alt_id: GO:0150113
+def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah, PMID:25962782]
synonym: "down regulation of interleukin-7 production" EXACT []
synonym: "down-regulation of interleukin-7 production" EXACT []
synonym: "downregulation of interleukin-7 production" EXACT []
synonym: "inhibition of interleukin-7 production" NARROW []
synonym: "negative regulation of IL-7 production" EXACT []
+synonym: "negative regulation of interleukin-7 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-7 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032676 ! regulation of interleukin-7 production
intersection_of: GO:0008150 ! biological_process
@@ -187663,12 +188226,16 @@ relationship: negatively_regulates GO:0032636 ! interleukin-7 production
id: GO:0032717
name: negative regulation of interleukin-8 production
namespace: biological_process
+alt_id: GO:0045415
+alt_id: GO:2000483
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "down regulation of interleukin-8 production" EXACT []
synonym: "down-regulation of interleukin-8 production" EXACT []
synonym: "downregulation of interleukin-8 production" EXACT []
synonym: "inhibition of interleukin-8 production" NARROW []
synonym: "negative regulation of IL-8 production" EXACT []
+synonym: "negative regulation of interleukin-8 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-8 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032677 ! regulation of interleukin-8 production
intersection_of: GO:0008150 ! biological_process
@@ -187679,12 +188246,14 @@ relationship: negatively_regulates GO:0032637 ! interleukin-8 production
id: GO:0032718
name: negative regulation of interleukin-9 production
namespace: biological_process
+alt_id: GO:0045418
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "down regulation of interleukin-9 production" EXACT []
synonym: "down-regulation of interleukin-9 production" EXACT []
synonym: "downregulation of interleukin-9 production" EXACT []
synonym: "inhibition of interleukin-9 production" NARROW []
synonym: "negative regulation of IL-9 production" EXACT []
+synonym: "negative regulation of interleukin-9 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032678 ! regulation of interleukin-9 production
intersection_of: GO:0008150 ! biological_process
@@ -187764,9 +188333,11 @@ relationship: positively_regulates GO:0032602 ! chemokine production
id: GO:0032723
name: positive regulation of connective tissue growth factor production
namespace: biological_process
+alt_id: GO:0045422
def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "activation of connective tissue growth factor production" NARROW []
synonym: "positive regulation of CCN2 production" EXACT []
+synonym: "positive regulation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "positive regulation of CTGF production" EXACT []
synonym: "positive regulation of Fisp12 production" EXACT []
synonym: "positive regulation of Hcs24 production" EXACT []
@@ -187836,8 +188407,12 @@ relationship: positively_regulates GO:0032605 ! hepatocyte growth factor product
id: GO:0032727
name: positive regulation of interferon-alpha production
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah]
+alt_id: GO:0045356
+alt_id: GO:1902741
+def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383]
synonym: "activation of interferon-alpha production" NARROW []
+synonym: "positive regulation of interferon-alpha biosynthetic process" NARROW []
+synonym: "positive regulation of interferon-alpha secretion" NARROW []
synonym: "stimulation of interferon-alpha production" NARROW []
synonym: "up regulation of interferon-alpha production" EXACT []
synonym: "up-regulation of interferon-alpha production" EXACT []
@@ -187852,9 +188427,13 @@ relationship: positively_regulates GO:0032607 ! interferon-alpha production
id: GO:0032728
name: positive regulation of interferon-beta production
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah]
+alt_id: GO:0035549
+alt_id: GO:0045359
+def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383]
synonym: "activation of interferon-beta production" NARROW []
synonym: "positive regulation of IFN-beta production" EXACT []
+synonym: "positive regulation of interferon-beta biosynthetic process" NARROW []
+synonym: "positive regulation of interferon-beta secretion" NARROW []
synonym: "stimulation of interferon-beta production" NARROW []
synonym: "up regulation of interferon-beta production" EXACT []
synonym: "up-regulation of interferon-beta production" EXACT []
@@ -187869,8 +188448,12 @@ relationship: positively_regulates GO:0032608 ! interferon-beta production
id: GO:0032729
name: positive regulation of interferon-gamma production
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
+alt_id: GO:0045078
+alt_id: GO:1902715
+def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383]
synonym: "activation of interferon-gamma production" NARROW []
+synonym: "positive regulation of interferon-gamma biosynthetic process" NARROW []
+synonym: "positive regulation of interferon-gamma secretion" NARROW []
synonym: "positive regulation of type II interferon production" BROAD []
synonym: "stimulation of interferon-gamma production" NARROW []
synonym: "up regulation of interferon-gamma production" EXACT []
@@ -187886,9 +188469,13 @@ relationship: positively_regulates GO:0032609 ! interferon-gamma production
id: GO:0032730
name: positive regulation of interleukin-1 alpha production
namespace: biological_process
+alt_id: GO:0050717
+alt_id: GO:0050726
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "activation of interleukin-1 alpha production" NARROW []
synonym: "positive regulation of IL-1 alpha production" EXACT []
+synonym: "positive regulation of interleukin-1 alpha biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-1 alpha secretion" NARROW []
synonym: "stimulation of interleukin-1 alpha production" NARROW []
synonym: "up regulation of interleukin-1 alpha production" EXACT []
synonym: "up-regulation of interleukin-1 alpha production" EXACT []
@@ -187903,9 +188490,13 @@ relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production
id: GO:0032731
name: positive regulation of interleukin-1 beta production
namespace: biological_process
+alt_id: GO:0050718
+alt_id: GO:0050725
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "activation of interleukin-1 beta production" NARROW []
synonym: "positive regulation of IL-1 beta production" EXACT []
+synonym: "positive regulation of interleukin-1 beta biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-1 beta secretion" NARROW []
synonym: "stimulation of interleukin-1 beta production" NARROW []
synonym: "up regulation of interleukin-1 beta production" EXACT []
synonym: "up-regulation of interleukin-1 beta production" EXACT []
@@ -187920,9 +188511,13 @@ relationship: positively_regulates GO:0032611 ! interleukin-1 beta production
id: GO:0032732
name: positive regulation of interleukin-1 production
namespace: biological_process
+alt_id: GO:0045362
+alt_id: GO:0050716
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "activation of interleukin-1 production" NARROW []
synonym: "positive regulation of IL-1 production" EXACT []
+synonym: "positive regulation of interleukin-1 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-1 secretion" NARROW []
synonym: "stimulation of interleukin-1 production" NARROW []
synonym: "up regulation of interleukin-1 production" EXACT []
synonym: "up-regulation of interleukin-1 production" EXACT []
@@ -187937,9 +188532,13 @@ relationship: positively_regulates GO:0032612 ! interleukin-1 production
id: GO:0032733
name: positive regulation of interleukin-10 production
namespace: biological_process
+alt_id: GO:0045082
+alt_id: GO:2001181
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "activation of interleukin-10 production" NARROW []
synonym: "positive regulation of IL-10 production" EXACT []
+synonym: "positive regulation of interleukin-10 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-10 secretion" NARROW []
synonym: "stimulation of interleukin-10 production" NARROW []
synonym: "up regulation of interleukin-10 production" EXACT []
synonym: "up-regulation of interleukin-10 production" EXACT []
@@ -187954,9 +188553,13 @@ relationship: positively_regulates GO:0032613 ! interleukin-10 production
id: GO:0032734
name: positive regulation of interleukin-11 production
namespace: biological_process
+alt_id: GO:0045365
+alt_id: GO:0150171
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
synonym: "activation of interleukin-11 production" NARROW []
synonym: "positive regulation of IL-11 production" EXACT []
+synonym: "positive regulation of interleukin-11 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-11 secretion" NARROW []
synonym: "stimulation of interleukin-11 production" NARROW []
synonym: "up regulation of interleukin-11 production" EXACT []
synonym: "up-regulation of interleukin-11 production" EXACT []
@@ -187971,9 +188574,15 @@ relationship: positively_regulates GO:0032614 ! interleukin-11 production
id: GO:0032735
name: positive regulation of interleukin-12 production
namespace: biological_process
+alt_id: GO:0045084
+alt_id: GO:2001184
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "activation of interleukin-12 production" NARROW []
+synonym: "positive regulation of CLMF production" RELATED [GOC:obol]
synonym: "positive regulation of IL-12 production" EXACT []
+synonym: "positive regulation of interleukin-12 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-12 secretion" NARROW []
+synonym: "positive regulation of NKSF production" RELATED [GOC:obol]
synonym: "stimulation of interleukin-12 production" NARROW []
synonym: "up regulation of interleukin-12 production" EXACT []
synonym: "up-regulation of interleukin-12 production" EXACT []
@@ -187988,9 +188597,13 @@ relationship: positively_regulates GO:0032615 ! interleukin-12 production
id: GO:0032736
name: positive regulation of interleukin-13 production
namespace: biological_process
+alt_id: GO:0045368
+alt_id: GO:2000667
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "activation of interleukin-13 production" NARROW []
synonym: "positive regulation of IL-13 production" EXACT []
+synonym: "positive regulation of interleukin-13 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-13 secretion" NARROW []
synonym: "stimulation of interleukin-13 production" NARROW []
synonym: "up regulation of interleukin-13 production" EXACT []
synonym: "up-regulation of interleukin-13 production" EXACT []
@@ -188005,9 +188618,11 @@ relationship: positively_regulates GO:0032616 ! interleukin-13 production
id: GO:0032737
name: positive regulation of interleukin-14 production
namespace: biological_process
+alt_id: GO:0045371
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
synonym: "activation of interleukin-14 production" NARROW []
synonym: "positive regulation of IL-14 production" EXACT []
+synonym: "positive regulation of interleukin-14 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-14 production" NARROW []
synonym: "up regulation of interleukin-14 production" EXACT []
synonym: "up-regulation of interleukin-14 production" EXACT []
@@ -188022,9 +188637,11 @@ relationship: positively_regulates GO:0032617 ! interleukin-14 production
id: GO:0032738
name: positive regulation of interleukin-15 production
namespace: biological_process
+alt_id: GO:0045374
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "activation of interleukin-15 production" NARROW []
synonym: "positive regulation of IL-15 production" EXACT []
+synonym: "positive regulation of interleukin-15 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-15 production" NARROW []
synonym: "up regulation of interleukin-15 production" EXACT []
synonym: "up-regulation of interleukin-15 production" EXACT []
@@ -188039,9 +188656,11 @@ relationship: positively_regulates GO:0032618 ! interleukin-15 production
id: GO:0032739
name: positive regulation of interleukin-16 production
namespace: biological_process
+alt_id: GO:0045377
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "activation of interleukin-16 production" NARROW []
synonym: "positive regulation of IL-16 production" EXACT []
+synonym: "positive regulation of interleukin-16 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-16 production" NARROW []
synonym: "up regulation of interleukin-16 production" EXACT []
synonym: "up-regulation of interleukin-16 production" EXACT []
@@ -188056,9 +188675,15 @@ relationship: positively_regulates GO:0032619 ! interleukin-16 production
id: GO:0032740
name: positive regulation of interleukin-17 production
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah]
+alt_id: GO:0045380
+alt_id: GO:1905078
+def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511]
synonym: "activation of interleukin-17 production" NARROW []
+synonym: "positive regulation of CTLA-8 production" EXACT [GOC:TermGenie]
+synonym: "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:TermGenie]
synonym: "positive regulation of IL-17 production" EXACT []
+synonym: "positive regulation of interleukin-17 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-17 secretion" NARROW []
synonym: "stimulation of interleukin-17 production" NARROW []
synonym: "up regulation of interleukin-17 production" EXACT []
synonym: "up-regulation of interleukin-17 production" EXACT []
@@ -188073,9 +188698,13 @@ relationship: positively_regulates GO:0032620 ! interleukin-17 production
id: GO:0032741
name: positive regulation of interleukin-18 production
namespace: biological_process
+alt_id: GO:0045383
+alt_id: GO:0150122
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
synonym: "activation of interleukin-18 production" NARROW []
synonym: "positive regulation of IL-18 production" EXACT []
+synonym: "positive regulation of interleukin-18 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-18 secretion" NARROW []
synonym: "stimulation of interleukin-18 production" NARROW []
synonym: "up regulation of interleukin-18 production" EXACT []
synonym: "up-regulation of interleukin-18 production" EXACT []
@@ -188090,9 +188719,11 @@ relationship: positively_regulates GO:0032621 ! interleukin-18 production
id: GO:0032742
name: positive regulation of interleukin-19 production
namespace: biological_process
+alt_id: GO:0045386
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "activation of interleukin-19 production" NARROW []
synonym: "positive regulation of IL-19 production" EXACT []
+synonym: "positive regulation of interleukin-19 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-19 production" NARROW []
synonym: "up regulation of interleukin-19 production" EXACT []
synonym: "up-regulation of interleukin-19 production" EXACT []
@@ -188107,9 +188738,13 @@ relationship: positively_regulates GO:0032622 ! interleukin-19 production
id: GO:0032743
name: positive regulation of interleukin-2 production
namespace: biological_process
+alt_id: GO:0045086
+alt_id: GO:1900042
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "activation of interleukin-2 production" NARROW []
synonym: "positive regulation of IL-2 production" EXACT []
+synonym: "positive regulation of interleukin-2 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-2 secretion" NARROW []
synonym: "stimulation of interleukin-2 production" NARROW []
synonym: "up regulation of interleukin-2 production" EXACT []
synonym: "up-regulation of interleukin-2 production" EXACT []
@@ -188124,9 +188759,11 @@ relationship: positively_regulates GO:0032623 ! interleukin-2 production
id: GO:0032744
name: positive regulation of interleukin-20 production
namespace: biological_process
+alt_id: GO:0045389
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "activation of interleukin-20 production" NARROW []
synonym: "positive regulation of IL-20 production" EXACT []
+synonym: "positive regulation of interleukin-20 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-20 production" NARROW []
synonym: "up regulation of interleukin-20 production" EXACT []
synonym: "up-regulation of interleukin-20 production" EXACT []
@@ -188141,9 +188778,11 @@ relationship: positively_regulates GO:0032624 ! interleukin-20 production
id: GO:0032745
name: positive regulation of interleukin-21 production
namespace: biological_process
+alt_id: GO:0045392
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "activation of interleukin-21 production" NARROW []
synonym: "positive regulation of IL-21 production" EXACT []
+synonym: "positive regulation of interleukin-21 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-21 production" NARROW []
synonym: "up regulation of interleukin-21 production" EXACT []
synonym: "up-regulation of interleukin-21 production" EXACT []
@@ -188158,9 +188797,11 @@ relationship: positively_regulates GO:0032625 ! interleukin-21 production
id: GO:0032746
name: positive regulation of interleukin-22 production
namespace: biological_process
+alt_id: GO:0045395
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "activation of interleukin-22 production" NARROW []
synonym: "positive regulation of IL-22 production" EXACT []
+synonym: "positive regulation of interleukin-22 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-22 production" NARROW []
synonym: "up regulation of interleukin-22 production" EXACT []
synonym: "up-regulation of interleukin-22 production" EXACT []
@@ -188175,9 +188816,11 @@ relationship: positively_regulates GO:0032626 ! interleukin-22 production
id: GO:0032747
name: positive regulation of interleukin-23 production
namespace: biological_process
+alt_id: GO:0045398
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "activation of interleukin-23 production" NARROW []
synonym: "positive regulation of IL-23 production" EXACT []
+synonym: "positive regulation of interleukin-23 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-23 production" NARROW []
synonym: "up regulation of interleukin-23 production" EXACT []
synonym: "up-regulation of interleukin-23 production" EXACT []
@@ -188192,9 +188835,11 @@ relationship: positively_regulates GO:0032627 ! interleukin-23 production
id: GO:0032748
name: positive regulation of interleukin-24 production
namespace: biological_process
+alt_id: GO:0045536
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "activation of interleukin-24 production" NARROW []
synonym: "positive regulation of IL-24 production" EXACT []
+synonym: "positive regulation of interleukin-24 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-24 production" NARROW []
synonym: "up regulation of interleukin-24 production" EXACT []
synonym: "up-regulation of interleukin-24 production" EXACT []
@@ -188209,9 +188854,13 @@ relationship: positively_regulates GO:0032628 ! interleukin-24 production
id: GO:0032749
name: positive regulation of interleukin-25 production
namespace: biological_process
+alt_id: GO:0045537
+alt_id: GO:0150150
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "activation of interleukin-25 production" NARROW []
synonym: "positive regulation of IL-25 production" EXACT []
+synonym: "positive regulation of interleukin-25 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-25 secretion" NARROW []
synonym: "stimulation of interleukin-25 production" NARROW []
synonym: "up regulation of interleukin-25 production" EXACT []
synonym: "up-regulation of interleukin-25 production" EXACT []
@@ -188221,14 +188870,18 @@ is_a: GO:0032669 ! regulation of interleukin-25 production
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0032629 ! interleukin-25 production
relationship: positively_regulates GO:0032629 ! interleukin-25 production
+created_by: bc
+creation_date: 2019-12-09T16:51:44Z
[Term]
id: GO:0032750
name: positive regulation of interleukin-26 production
namespace: biological_process
+alt_id: GO:0045538
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "activation of interleukin-26 production" NARROW []
synonym: "positive regulation of IL-26 production" EXACT []
+synonym: "positive regulation of interleukin-26 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-26 production" NARROW []
synonym: "up regulation of interleukin-26 production" EXACT []
synonym: "up-regulation of interleukin-26 production" EXACT []
@@ -188243,9 +188896,12 @@ relationship: positively_regulates GO:0032630 ! interleukin-26 production
id: GO:0032751
name: positive regulation of interleukin-27 production
namespace: biological_process
+alt_id: GO:0045539
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "activation of interleukin-27 production" NARROW []
synonym: "positive regulation of IL-27 production" EXACT []
+synonym: "positive regulation of interleukin-27 anabolism" NARROW []
+synonym: "positive regulation of interleukin-27 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-27 production" NARROW []
synonym: "up regulation of interleukin-27 production" EXACT []
synonym: "up-regulation of interleukin-27 production" EXACT []
@@ -188260,9 +188916,11 @@ relationship: positively_regulates GO:0032631 ! interleukin-27 production
id: GO:0032752
name: positive regulation of interleukin-3 production
namespace: biological_process
+alt_id: GO:0045401
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "activation of interleukin-3 production" NARROW []
synonym: "positive regulation of IL-3 production" EXACT []
+synonym: "positive regulation of interleukin-3 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-3 production" NARROW []
synonym: "up regulation of interleukin-3 production" EXACT []
synonym: "up-regulation of interleukin-3 production" EXACT []
@@ -188277,9 +188935,13 @@ relationship: positively_regulates GO:0032632 ! interleukin-3 production
id: GO:0032753
name: positive regulation of interleukin-4 production
namespace: biological_process
+alt_id: GO:0045404
+alt_id: GO:0150135
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
synonym: "activation of interleukin-4 production" NARROW []
synonym: "positive regulation of IL-4 production" EXACT []
+synonym: "positive regulation of interleukin-4 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-4 secretion" NARROW []
synonym: "stimulation of interleukin-4 production" NARROW []
synonym: "up regulation of interleukin-4 production" EXACT []
synonym: "up-regulation of interleukin-4 production" EXACT []
@@ -188294,9 +188956,13 @@ relationship: positively_regulates GO:0032633 ! interleukin-4 production
id: GO:0032754
name: positive regulation of interleukin-5 production
namespace: biological_process
+alt_id: GO:0045407
+alt_id: GO:2000664
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "activation of interleukin-5 production" NARROW []
synonym: "positive regulation of IL-5 production" EXACT []
+synonym: "positive regulation of interleukin-5 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-5 secretion" NARROW []
synonym: "stimulation of interleukin-5 production" NARROW []
synonym: "up regulation of interleukin-5 production" EXACT []
synonym: "up-regulation of interleukin-5 production" EXACT []
@@ -188311,9 +188977,13 @@ relationship: positively_regulates GO:0032634 ! interleukin-5 production
id: GO:0032755
name: positive regulation of interleukin-6 production
namespace: biological_process
+alt_id: GO:0045410
+alt_id: GO:2000778
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "activation of interleukin-6 production" NARROW []
synonym: "positive regulation of IL-6 production" EXACT []
+synonym: "positive regulation of interleukin-6 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-6 secretion" NARROW []
synonym: "stimulation of interleukin-6 production" NARROW []
synonym: "up regulation of interleukin-6 production" EXACT []
synonym: "up-regulation of interleukin-6 production" EXACT []
@@ -188328,9 +188998,13 @@ relationship: positively_regulates GO:0032635 ! interleukin-6 production
id: GO:0032756
name: positive regulation of interleukin-7 production
namespace: biological_process
+alt_id: GO:0045413
+alt_id: GO:0150114
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
synonym: "activation of interleukin-7 production" NARROW []
synonym: "positive regulation of IL-7 production" EXACT []
+synonym: "positive regulation of interleukin-7 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-7 secretion" NARROW []
synonym: "stimulation of interleukin-7 production" NARROW []
synonym: "up regulation of interleukin-7 production" EXACT []
synonym: "up-regulation of interleukin-7 production" EXACT []
@@ -188345,9 +189019,13 @@ relationship: positively_regulates GO:0032636 ! interleukin-7 production
id: GO:0032757
name: positive regulation of interleukin-8 production
namespace: biological_process
+alt_id: GO:0045416
+alt_id: GO:2000484
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "activation of interleukin-8 production" NARROW []
synonym: "positive regulation of IL-8 production" EXACT []
+synonym: "positive regulation of interleukin-8 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-8 secretion" NARROW []
synonym: "stimulation of interleukin-8 production" NARROW []
synonym: "up regulation of interleukin-8 production" EXACT []
synonym: "up-regulation of interleukin-8 production" EXACT []
@@ -188362,9 +189040,11 @@ relationship: positively_regulates GO:0032637 ! interleukin-8 production
id: GO:0032758
name: positive regulation of interleukin-9 production
namespace: biological_process
+alt_id: GO:0045419
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "activation of interleukin-9 production" NARROW []
synonym: "positive regulation of IL-9 production" EXACT []
+synonym: "positive regulation of interleukin-9 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-9 production" NARROW []
synonym: "up regulation of interleukin-9 production" EXACT []
synonym: "up-regulation of interleukin-9 production" EXACT []
@@ -188669,6 +189349,7 @@ id: GO:0032782
name: bile acid secretion
namespace: biological_process
def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd]
+is_a: GO:0006869 ! lipid transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0046717 ! acid secretion
@@ -188833,8 +189514,8 @@ def: "A protein complex that contains the survival motor neuron (SMN) protein an
comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'.
synonym: "SMN core complex" EXACT []
synonym: "survival motor neuron complex" EXACT []
-is_a: GO:0032991 ! protein-containing complex
-relationship: part_of GO:0005622 ! intracellular
+is_a: GO:0120114 ! Sm-like protein family complex
+relationship: part_of GO:0034719 ! SMN-Sm protein complex
[Term]
id: GO:0032798
@@ -189482,7 +190163,6 @@ id: GO:0032841
name: calcitonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd]
-is_a: GO:0008144 ! drug binding
is_a: GO:0097644 ! calcitonin family binding
[Term]
@@ -189557,7 +190237,7 @@ relationship: positively_regulates GO:0051452 ! intracellular pH reduction
id: GO:0032865
name: ERMES complex
namespace: cellular_component
-def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth." [GOC:mcc, PMID:19556461]
+def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles." [GOC:mcc, PMID:19556461, PMID:29279306]
synonym: "ER-mitochondria encounter structure" EXACT []
synonym: "Mdm10/Mdm12/Mmm1 complex" EXACT []
synonym: "mitochore" EXACT [GOC:mcc]
@@ -189790,7 +190470,6 @@ name: regulation of chitin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah]
synonym: "regulation of chitin metabolism" EXACT []
-is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -191322,6 +192001,7 @@ id: GO:0033013
name: tetrapyrrole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]
+subset: goslim_pombe
synonym: "tetrapyrrole metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
@@ -191738,7 +192418,6 @@ name: clavulanic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [GOC:mah]
synonym: "clavulanic acid metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
@@ -191755,7 +192434,6 @@ synonym: "clavulanic acid biosynthesis" EXACT []
synonym: "clavulanic acid formation" EXACT []
synonym: "clavulanic acid synthesis" EXACT []
xref: Wikipedia:Clavulanic_acid
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0033049 ! clavulanic acid metabolic process
is_a: GO:0043604 ! amide biosynthetic process
@@ -191767,8 +192445,9 @@ is_a: GO:1901566 ! organonitrogen compound biosynthetic process
id: GO:0033051
name: aminophosphonate metabolic process
namespace: biological_process
-def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah, http://pages.unibas.ch/mdpi/ecsoc/a0045/a0045.htm, KEGG:map00440]
+def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah]
synonym: "aminophosphonate metabolism" EXACT []
+xref: KEGG_PATHWAY:map00440
is_a: GO:0019634 ! organic phosphonate metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
@@ -191847,7 +192526,7 @@ is_a: GO:0043473 ! pigmentation
id: GO:0033061
name: DNA recombinase mediator complex
namespace: cellular_component
-def: "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA." [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992]
+def: "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange." [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992, PMID:32414915]
comment: Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly.
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
@@ -193296,9 +193975,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl]
synonym: "response to adenosine 5'-triphosphate" EXACT []
synonym: "response to adenosine triphosphate" EXACT []
-is_a: GO:0007584 ! response to nutrient
is_a: GO:0014074 ! response to purine-containing compound
-is_a: GO:0042493 ! response to drug
is_a: GO:0046683 ! response to organophosphorus
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -193521,7 +194198,7 @@ namespace: biological_process
def: "The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]
synonym: "2-phosphonoethylamine transport" EXACT []
synonym: "ciliatine transport" EXACT []
-is_a: GO:0071702 ! organic substance transport
+is_a: GO:0015695 ! organic cation transport
is_a: GO:0071705 ! nitrogen compound transport
[Term]
@@ -193531,7 +194208,8 @@ namespace: molecular_function
def: "Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other." [GOC:mlg]
synonym: "2-phosphonoethylamine transmembrane transporter activity" EXACT []
synonym: "ciliatine transporter activity" EXACT []
-is_a: GO:0022804 ! active transmembrane transporter activity
+is_a: GO:0015101 ! organic cation transmembrane transporter activity
+is_a: GO:0022853 ! active ion transmembrane transporter activity
relationship: part_of GO:0033223 ! 2-aminoethylphosphonate transport
[Term]
@@ -193546,7 +194224,7 @@ synonym: "ATP-dependent 2-aminoethylphosphonate transporter activity" EXACT []
synonym: "ciliatine transportingATPase activity" EXACT []
xref: RHEA:32775
is_a: GO:0033224 ! 2-aminoethylphosphonate transmembrane transporter activity
-is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
+is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity
[Term]
id: GO:0033226
@@ -193555,7 +194233,7 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with 2-aminoethylphosphonate." [GOC:mlg]
synonym: "2-phosphonoethylamine binding" EXACT []
synonym: "ciliatine binding" EXACT []
-is_a: GO:0005488 ! binding
+is_a: GO:0043169 ! cation binding
[Term]
id: GO:0033227
@@ -193673,8 +194351,6 @@ synonym: "11-beta-hydroxysteroid dehydrogenase (NADP+) activity" EXACT []
synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146]
-xref: EC:1.1.1.146
-xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
is_obsolete: true
replaced_by: GO:0070524
@@ -194009,8 +194685,6 @@ comment: This term was made obsolete because it represents a gene product.
synonym: "BoNT" RELATED [EC:3.4.24.69]
synonym: "bontoxilysin activity" EXACT []
synonym: "botulinum neurotoxin activity" EXACT []
-xref: EC:3.4.24.69
-xref: MetaCyc:3.4.24.69-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -194019,7 +194693,6 @@ id: GO:0033265
name: choline binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [GOC:mlg]
-is_a: GO:0042165 ! neurotransmitter binding
is_a: GO:0043169 ! cation binding
[Term]
@@ -194090,7 +194763,6 @@ name: myo-inositol hexakisphosphate transport
namespace: biological_process
def: "The directed movement of myo-inositol hexakisphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "phytate transport" EXACT []
-is_a: GO:0015893 ! drug transport
is_a: GO:0033271 ! myo-inositol phosphate transport
[Term]
@@ -194109,7 +194781,6 @@ synonym: "response to riboflavin" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
-is_a: GO:0042493 ! response to drug
[Term]
id: GO:0033275
@@ -194347,7 +195018,8 @@ namespace: molecular_function
def: "Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other." [GOC:go_curators]
synonym: "dehydroascorbate transporter activity" EXACT []
synonym: "dehydroascorbic acid transporter activity" RELATED []
-xref: Reactome:R-HSA-198818 "GLUT1/3 transports extracellular DHvitC to cytosol"
+xref: Reactome:R-HSA-198818 "SLC2A1,3 transports DeHA from extracellular region to cytosol"
+xref: RHEA:60380
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
relationship: part_of GO:0070837 ! dehydroascorbic acid transport
@@ -194410,7 +195082,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [GOC:mah]
synonym: "phytol metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:1903173 ! fatty alcohol metabolic process
@@ -194647,7 +195318,6 @@ name: kaempferol O-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [GOC:mah, MetaCyc:PWY-5320]
synonym: "kaempferol O-glucoside metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
is_a: GO:1901804 ! beta-glucoside metabolic process
@@ -194662,7 +195332,6 @@ synonym: "kaempferol O-glucoside biosynthesis" EXACT []
synonym: "kaempferol O-glucoside formation" EXACT []
synonym: "kaempferol O-glucoside synthesit" EXACT []
xref: MetaCyc:PWY-5320
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0033329 ! kaempferol O-glucoside metabolic process
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
@@ -196387,7 +197056,6 @@ name: ferulate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [GOC:mah]
synonym: "ferulate metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
@@ -196563,7 +197231,6 @@ name: luteolin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [GOC:mah]
synonym: "luteolin metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
@@ -196641,7 +197308,6 @@ def: "The chemical reactions and pathways involving phytic acid, myo-inositol he
synonym: "myo-inositol hexakisphosphate metabolism" EXACT []
synonym: "phytate metabolic process" EXACT []
synonym: "phytate metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0043647 ! inositol phosphate metabolic process
[Term]
@@ -197083,6 +197749,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pde]
xref: Reactome:R-HSA-197963 "Folate is reduced to dihydrofolate (DHF)"
xref: Reactome:R-HSA-197972 "DHF is reduced to tetrahydrofolate (THF)"
+xref: RHEA:31103
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
[Term]
@@ -197208,7 +197875,6 @@ name: response to testosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl]
synonym: "response to testosterone stimulus" EXACT [GOC:dos]
-is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901654 ! response to ketone
@@ -197379,7 +198045,6 @@ synonym: "response to vitamin B12" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
-is_a: GO:0042493 ! response to drug
[Term]
id: GO:0033591
@@ -197389,7 +198054,6 @@ def: "Any process that results in a change in state or activity of a cell or an
synonym: "response to ascorbic acid" BROAD []
synonym: "response to L-ascorbate" EXACT []
synonym: "response to vitamin C" EXACT []
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0033273 ! response to vitamin
is_a: GO:0034284 ! response to monosaccharide
@@ -197423,9 +198087,7 @@ id: GO:0033595
name: response to genistein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah]
-is_a: GO:0009725 ! response to hormone
is_a: GO:0033594 ! response to hydroxyisoflavone
-is_a: GO:0097327 ! response to antineoplastic agent
[Term]
id: GO:0033596
@@ -197515,7 +198177,6 @@ is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0033604 ! negative regulation of catecholamine secretion
is_a: GO:0043271 ! negative regulation of ion transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0014046 ! dopamine secretion
relationship: negatively_regulates GO:0014046 ! dopamine secretion
@@ -197535,7 +198196,6 @@ is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0033605 ! positive regulation of catecholamine secretion
is_a: GO:0043270 ! positive regulation of ion transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0014046 ! dopamine secretion
relationship: positively_regulates GO:0014046 ! dopamine secretion
@@ -197975,6 +198635,7 @@ is_a: GO:0018995 ! host cellular component
intersection_of: GO:0018995 ! host cellular component
intersection_of: part_of GO:0043657 ! host cell
relationship: part_of GO:0043657 ! host cell
+property_value: RO:0002161 NCBITaxon:7742
[Term]
id: GO:0033644
@@ -198324,6 +198985,7 @@ def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction driv
synonym: "5' to 3' DNA/RNA helicase activity" EXACT []
synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT []
synonym: "ATP-dependent 5'-3' DNA/RNA helicase activity" EXACT []
+xref: Reactome:R-HSA-163120 "Disassociation of Telomerase RNP and the Chromosome End"
is_a: GO:0033677 ! DNA/RNA helicase activity
[Term]
@@ -198780,6 +199442,7 @@ synonym: "2-oxoacid reductase activity" EXACT [EC:1.1.99.30]
synonym: "HVOR" RELATED [EC:1.1.99.30]
xref: EC:1.1.99.30
xref: MetaCyc:1.1.99.30-RXN
+xref: RHEA:23664
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
[Term]
@@ -198841,6 +199504,7 @@ synonym: "AOR" RELATED [EC:1.2.7.5]
synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5]
xref: EC:1.2.7.5
xref: MetaCyc:1.2.7.5-RXN
+xref: RHEA:16421
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
[Term]
@@ -198993,6 +199657,7 @@ synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1]
synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" EXACT [EC:1.5.7.1]
xref: EC:1.5.7.1
xref: MetaCyc:RXN-5061
+xref: RHEA:14229
is_a: GO:0033694 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor
[Term]
@@ -199197,6 +199862,7 @@ synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52]
xref: EC:1.13.11.52
xref: MetaCyc:RXN-8664
xref: MetaCyc:RXN-8665
+xref: RHEA:14189
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
[Term]
@@ -199252,6 +199918,7 @@ synonym: "clavaminic acid synthase activity" EXACT [EC:1.14.11.21]
synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.21]
xref: EC:1.14.11.21
xref: MetaCyc:1.14.11.21-RXN
+xref: RHEA:20021
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
[Term]
@@ -199523,6 +200190,7 @@ synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" EXACT [EC:1.14.1
synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" EXACT [EC:1.14.13.97]
xref: EC:1.14.13.97
xref: MetaCyc:RXN-7977
+xref: RHEA:23644
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -199595,6 +200263,7 @@ def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-be
synonym: "D-alpha,beta-D-heptose 7-phosphate 1-kinase activity" EXACT []
xref: EC:2.7.1
xref: MetaCyc:RXN0-4341
+xref: RHEA:27473
is_a: GO:0019200 ! carbohydrate kinase activity
[Term]
@@ -199605,6 +200274,7 @@ def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glyc
synonym: "D-beta-D-heptose 1-phosphate adenylyltransferase activity" EXACT []
synonym: "heptose 1-phosphate adenyltransferase activity" EXACT []
xref: MetaCyc:RXN0-4342
+xref: RHEA:27465
is_a: GO:0070566 ! adenylyltransferase activity
[Term]
@@ -199726,6 +200396,7 @@ synonym: "sulphur reductase activity" EXACT []
xref: EC:1.12.98.4
xref: MetaCyc:1.97.1.3-RXN
xref: MetaCyc:RXN-8269
+xref: RHEA:35591
is_a: GO:0016491 ! oxidoreductase activity
[Term]
@@ -199762,7 +200433,7 @@ id: GO:0033799
name: myricetin 3'-O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0102437
-def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [MetaCyc:RXN-8451, RHEA:25629]
+def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [RHEA:25629]
comment: Note that this term represents one of two reactions that are grouped together in EC:2.1.1.267
synonym: "CrCOMT2" RELATED []
synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED []
@@ -199796,6 +200467,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-
synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" EXACT [EC:2.1.1.153]
xref: EC:2.1.1.153
xref: MetaCyc:RXN-4981
+xref: RHEA:11432
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
@@ -199907,6 +200579,7 @@ synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferas
synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171]
xref: EC:2.3.1.171
xref: MetaCyc:2.3.1.171-RXN
+xref: RHEA:16025
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -200027,6 +200700,7 @@ synonym: "KAS II" RELATED [EC:2.3.1.179]
synonym: "KASII" RELATED [EC:2.3.1.179]
xref: EC:2.3.1.179
xref: MetaCyc:2.3.1.179-RXN
+xref: RHEA:14565
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -200129,6 +200803,7 @@ synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" EXACT
xref: EC:2.4.1.66
xref: MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-1981157 "Glucosylation of collagen propeptide hydroxylysines"
+xref: RHEA:12576
is_a: GO:0046527 ! glucosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -200223,6 +200898,7 @@ synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" EXACT [EC:
synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" EXACT [EC:2.4.1.229]
synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229]
xref: EC:2.4.1.229
+xref: RHEA:17841
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -200246,6 +200922,7 @@ def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glu
synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.231]
synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231]
xref: MetaCyc:RXN-4441
+xref: RHEA:16257
is_a: GO:0046527 ! glucosyltransferase activity
[Term]
@@ -200265,6 +200942,7 @@ synonym: "F3GalTase activity" EXACT [EC:2.4.1.234]
synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.234]
xref: EC:2.4.1.234
xref: MetaCyc:2.4.1.234-RXN
+xref: RHEA:15709
is_a: GO:0008378 ! galactosyltransferase activity
[Term]
@@ -200281,6 +200959,7 @@ xref: MetaCyc:RXN-5002
xref: MetaCyc:RXN-5004
xref: MetaCyc:RXN-7759
xref: MetaCyc:RXN-9699
+xref: RHEA:15473
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -200305,6 +200984,7 @@ synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" EXAC
synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" EXACT [EC:2.4.1.238]
xref: EC:2.4.1.238
xref: MetaCyc:2.4.1.238-RXN
+xref: RHEA:35627
is_a: GO:0046527 ! glucosyltransferase activity
[Term]
@@ -200347,6 +201027,7 @@ synonym: "starch synthase II activity" EXACT [EC:2.4.1.242]
synonym: "waxy protein" RELATED [EC:2.4.1.242]
xref: EC:2.4.1.242
xref: MetaCyc:2.4.1.242-RXN
+xref: RHEA:15873
is_a: GO:0046527 ! glucosyltransferase activity
[Term]
@@ -200598,6 +201279,7 @@ synonym: "GK2" RELATED [EC:2.7.1.157]
synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" EXACT [EC:2.7.1.157]
xref: EC:2.7.1.157
xref: MetaCyc:2.7.1.157-RXN
+xref: RHEA:12617
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity
@@ -200928,6 +201610,7 @@ synonym: "vitamin B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74]
synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74]
xref: EC:3.1.3.74
xref: MetaCyc:3.1.3.74-RXN
+xref: RHEA:20533
is_a: GO:0016791 ! phosphatase activity
[Term]
@@ -201377,6 +202060,7 @@ synonym: "exopolygalacturanosidase activity" EXACT [EC:3.2.1.82]
synonym: "exopolygalacturonosidase activity" EXACT [EC:3.2.1.82]
xref: EC:3.2.1.82
xref: MetaCyc:3.2.1.82-RXN
+xref: RHEA:56232
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -201402,6 +202086,7 @@ xref: EC:3.2.1.84
xref: MetaCyc:3.2.1.84-RXN
xref: Reactome:R-HSA-532667 "Removal of the second glucose by glucosidase II"
xref: Reactome:R-HSA-548890 "Removal of the third glucose by glucosidase II and release from the chaperone"
+xref: Reactome:R-HSA-9683663 "N-glycan trimming of Spike"
is_a: GO:0090600 ! alpha-1,3-glucosidase activity
[Term]
@@ -201416,6 +202101,7 @@ synonym: "phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85]
synonym: "phospho-beta-galactosidase activity" EXACT [EC:3.2.1.85]
xref: EC:3.2.1.85
xref: MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN
+xref: RHEA:24568
is_a: GO:0015925 ! galactosidase activity
[Term]
@@ -201871,6 +202557,7 @@ synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidas
xref: EC:3.2.1.161
xref: MetaCyc:3.2.1.161-RXN
xref: MetaCyc:RXN-9156
+xref: RHEA:21488
is_a: GO:0008422 ! beta-glucosidase activity
[Term]
@@ -202007,6 +202694,7 @@ def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine
synonym: "N-benzylformamide amidohydrolase activity" EXACT [EC:3.5.1.91]
synonym: "NfdA" RELATED [EC:3.5.1.91]
xref: MetaCyc:3.5.1.91-RXN
+xref: RHEA:12096
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -202155,6 +202843,7 @@ synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.11]
synonym: "DL-DEXr" RELATED [EC:3.8.1.11]
xref: EC:3.8.1.11
xref: MetaCyc:3.8.1.11-RXN
+xref: RHEA:12072
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds
[Term]
@@ -202278,7 +202967,6 @@ id: GO:0033986
name: response to methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:sl]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0097305 ! response to alcohol
[Term]
@@ -202320,6 +203008,7 @@ xref: EC:4.2.1.107
xref: MetaCyc:4.2.1.107-RXN
xref: Reactome:R-HSA-192331 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA"
xref: Reactome:R-HSA-193535 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA"
+xref: RHEA:18933
is_a: GO:0016836 ! hydro-lyase activity
[Term]
@@ -202350,6 +203039,7 @@ synonym: "AUDH" RELATED [EC:4.2.1.110]
synonym: "pyranosone dehydratase activity" EXACT [EC:4.2.1.110]
xref: EC:4.2.1.110
xref: MetaCyc:4.2.1.110-RXN
+xref: RHEA:12100
is_a: GO:0016836 ! hydro-lyase activity
[Term]
@@ -202528,6 +203218,7 @@ synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-
xref: EC:4.2.3.22
xref: KEGG_REACTION:R07647
xref: MetaCyc:RXN-8648
+xref: RHEA:22436
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
[Term]
@@ -202641,6 +203332,7 @@ synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" EXACT [EC:4.6.1.15]
synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" EXACT [EC:4.6.1.15]
synonym: "FMN cyclase activity" EXACT [EC:4.6.1.15]
xref: EC:4.6.1.15
+xref: RHEA:13729
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity
@@ -202654,6 +203346,7 @@ synonym: "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.99.1.5]
synonym: "OxdA" RELATED [EC:4.99.1.5]
xref: EC:4.99.1.5
xref: MetaCyc:4.99.1.5-RXN
+xref: RHEA:11316
is_a: GO:0016881 ! acid-amino acid ligase activity
[Term]
@@ -202711,6 +203404,7 @@ synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14]
synonym: "trans-2-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14]
xref: EC:5.3.3.14
xref: MetaCyc:5.3.3.14-RXN
+xref: RHEA:23568
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds
[Term]
@@ -202823,6 +203517,7 @@ synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12]
synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" EXACT [EC:6.3.1.12]
xref: EC:6.3.1.12
xref: MetaCyc:6.3.1.12-RXN
+xref: RHEA:10752
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity
[Term]
@@ -202987,6 +203682,7 @@ xref: EC:2.5.1.46
xref: MetaCyc:2.5.1.46-RXN
xref: Reactome:R-HSA-204617 "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A"
xref: Reactome:R-HSA-204647 "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine"
+xref: RHEA:33299
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
[Term]
@@ -203353,6 +204049,7 @@ name: marneral synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581]
xref: MetaCyc:RXN-9664
+xref: RHEA:31875
is_a: GO:0031559 ! oxidosqualene cyclase activity
[Term]
@@ -203362,6 +204059,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)." [GOC:cb, PMID:16774269, PMID:17474751]
xref: EC:4.2.1.124
xref: MetaCyc:RXN-9684
+xref: RHEA:31035
is_a: GO:0031559 ! oxidosqualene cyclase activity
[Term]
@@ -204749,6 +205447,7 @@ name: D,D-heptose 1,7-bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate." [MetaCyc:RXN0-4361, PMID:11279237]
xref: MetaCyc:RXN0-4361
+xref: RHEA:28518
is_a: GO:0016791 ! phosphatase activity
[Term]
@@ -204865,7 +205564,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of quinolin
synonym: "quinolinate breakdown" EXACT []
synonym: "quinolinate catabolism" EXACT []
synonym: "quinolinate degradation" EXACT []
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046874 ! quinolinate metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
@@ -205022,6 +205720,8 @@ namespace: biological_process
def: "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]
synonym: "tRNA sulfurtransferase activity" RELATED [GOC:mah]
synonym: "tRNA thiolation" EXACT [PMID:24774365]
+xref: EC:2.8.1.4
+xref: MetaCyc:TRNA-S-TRANSFERASE-RXN
is_a: GO:0006400 ! tRNA modification
[Term]
@@ -205093,7 +205793,6 @@ def: "Any process that modulates the frequency, rate or extent of the chemical r
synonym: "regulation of cell wall chitin breakdown" EXACT []
synonym: "regulation of cell wall chitin catabolism" EXACT []
synonym: "regulation of cell wall chitin degradation" EXACT []
-is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0034222 ! regulation of cell wall chitin metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
intersection_of: GO:0008150 ! biological_process
@@ -205244,7 +205943,7 @@ alt_id: GO:0000998
alt_id: GO:0001142
alt_id: GO:0001143
alt_id: GO:0001144
-def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by mitochondrial RNA polymerase." [GOC:txnOH-2018, PMID:18391175]
+def: "Interacting selectively and non-covalently with a specific double-stranded mitochondrial DNA sequence in order to modulate transcription by mitochondrial RNA polymerase." [GOC:txnOH-2018, PMID:18391175]
synonym: "mitochondrial polymerase transcription factor activity" EXACT []
synonym: "mitochondrial RNA polymerase binding promoter specificity activity" EXACT []
synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" EXACT []
@@ -205589,7 +206288,6 @@ def: "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyqui
synonym: "4-hydroxyquinoline-2-carboxylic acid metabolic process" EXACT []
synonym: "kynurenic acid metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -205628,7 +206326,7 @@ is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
id: GO:0034278
name: stemar-13-ene synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." [MetaCyc:RXN-4882, RHEA:25552]
+def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." [RHEA:25552]
synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09115]
xref: EC:4.2.3.33
xref: KEGG_REACTION:R09115
@@ -205640,7 +206338,7 @@ is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
id: GO:0034279
name: syn-pimara-7,15-diene synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate." [MetaCyc:RXN-4883, RHEA:25560]
+def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate." [RHEA:25560]
synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09117]
xref: EC:4.2.3.35
xref: KEGG_REACTION:R09117
@@ -205652,7 +206350,7 @@ is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
id: GO:0034280
name: ent-sandaracopimaradiene synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate." [MetaCyc:RXN-4884, RHEA:25536]
+def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate." [RHEA:25536]
synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09120]
synonym: "ent-pimaradiene synthase activity" BROAD []
xref: EC:4.2.3.29
@@ -206261,9 +206959,11 @@ relationship: part_of GO:0045087 ! innate immune response
id: GO:0034343
name: type III interferon production
namespace: biological_process
+alt_id: GO:0072644
def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "type III IFN production" EXACT []
+synonym: "type III interferon secretion" NARROW []
is_a: GO:0001816 ! cytokine production
[Term]
@@ -206723,6 +207423,7 @@ def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semiald
synonym: "gamma-aminobutyric acid pyruvate transaminase activity" EXACT [EC:2.6.1.96]
xref: EC:2.6.1.96
xref: MetaCyc:RXN-6902
+xref: RHEA:32263
is_a: GO:0003867 ! 4-aminobutyrate transaminase activity
[Term]
@@ -206869,7 +207570,7 @@ relationship: part_of GO:0031981 ! nuclear lumen
id: GO:0034400
name: gerontoplast
namespace: cellular_component
-def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:16151876]
+def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:24668747]
is_a: GO:0009536 ! plastid
[Term]
@@ -207283,7 +207984,6 @@ namespace: molecular_function
def: "OBSOLETE. Enables the transfer of a glycoprotein from one side of a membrane to the other." [GOC:BHF, GOC:mah, GOC:rl]
comment: This term was obsoleted because there is no transmembrane transporter specific for glycoproteins.
synonym: "glycoprotein transporter activity" RELATED []
-xref: Reactome:R-HSA-1022127 "OS9:SEL1:ERAD E3 ligase:DERL2 transports Ub-unfolded protein:(GlcNAc)2 (Man)9-5 from ERQC to cytosol"
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17130 xsd:anyURI
is_obsolete: true
@@ -207528,9 +208228,7 @@ id: GO:0034465
name: response to carbon monoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:ecd]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0010033 ! response to organic substance
-is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
[Term]
@@ -207707,6 +208405,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate." [GOC:pf]
xref: MetaCyc:RXN-10036
xref: Reactome:R-HSA-1675949 "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane"
+xref: RHEA:25528
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity
@@ -207969,7 +208668,6 @@ def: "Any process that results in a change in state or activity of a cell or an
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
-is_a: GO:0042493 ! response to drug
[Term]
id: GO:0034517
@@ -208216,6 +208914,7 @@ name: fumarylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+." [UM-BBD_reactionID:r0811]
xref: EC:3.7.1.20
+xref: RHEA:26168
xref: UM-BBD_reactionID:r0811
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
@@ -208723,6 +209422,7 @@ xref: KEGG_REACTION:R08549
xref: MetaCyc:2OXOGLUTARATEDEH-RXN
xref: Reactome:R-HSA-71037 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+"
xref: Reactome:R-HSA-71401 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+"
+xref: RHEA:27786
is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity
[Term]
@@ -208867,8 +209567,6 @@ def: "Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6
synonym: "BH4 binding" EXACT []
synonym: "H4biopterin binding" EXACT []
synonym: "sapropterin binding" EXACT []
-is_a: GO:0008144 ! drug binding
-is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
@@ -208983,6 +209681,9 @@ namespace: molecular_function
def: "Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk]
synonym: "retinol transporter activity" RELATED []
synonym: "vitamin A1 transporter activity" EXACT []
+xref: Reactome:R-HSA-1467466 "ABCA4 mediates atRAL transport"
+xref: Reactome:R-HSA-2466749 "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol"
+xref: Reactome:R-HSA-2466802 "Defective ABCA4 does not transport NRPE from disc membranes"
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
is_a: GO:0090482 ! vitamin transmembrane transporter activity
@@ -209004,7 +209705,6 @@ namespace: molecular_function
def: "Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other." [GOC:mah]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0042937 ! tripeptide transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
relationship: part_of GO:0034775 ! glutathione transmembrane transport
@@ -209016,7 +209716,6 @@ namespace: biological_process
def: "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0042939 ! tripeptide transport
-is_a: GO:0051181 ! cofactor transport
is_a: GO:0072337 ! modified amino acid transport
is_a: GO:0072348 ! sulfur compound transport
@@ -209179,7 +209878,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "cortisol metabolism" EXACT []
is_a: GO:0008211 ! glucocorticoid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process
@@ -209664,6 +210362,7 @@ name: allulose 6-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate." [GOC:imk]
xref: MetaCyc:RXN0-304
+xref: RHEA:28426
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives
[Term]
@@ -209866,6 +210565,8 @@ def: "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9,
synonym: "gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9]
xref: EC:3.4.19.9
xref: MetaCyc:3.4.19.9-RXN
+xref: RHEA:56784
+is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0008242 ! omega peptidase activity
[Term]
@@ -210387,6 +211088,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate." [EC:4.2.3.106, PMID:12624761]
xref: EC:4.2.3.106
xref: MetaCyc:RXN-5109
+xref: RHEA:32691
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
[Term]
@@ -210546,6 +211248,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+." [UM-BBD_reactionID:r1034]
xref: EC:1.14.13
xref: MetaCyc:RXN-10446
+xref: RHEA:35307
xref: UM-BBD_reactionID:r1034
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -211603,6 +212306,7 @@ name: 6-hydroxypseudooxynicotine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine." [UM-BBD_reactionID:r1441]
xref: EC:1.5.99.14
+xref: RHEA:34223
xref: UM-BBD_reactionID:r1441
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors
@@ -212182,6 +212886,7 @@ xref: Reactome:R-HSA-5685953 "SIRT6 deacetylates RBBP8"
xref: Reactome:R-HSA-5688289 "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2"
xref: Reactome:R-HSA-5688294 "SIRT5 deacetylates Cytochrome C"
xref: Reactome:R-HSA-9620532 "SIRT1,SIRT3 deacetylate FOXO3"
+xref: Reactome:R-HSA-9667952 "ANKLE2 is deacetylated by SIRT2"
is_a: GO:0033558 ! protein deacetylase activity
[Term]
@@ -212391,6 +213096,7 @@ synonym: "phosphoinositide 3-kinase activity" EXACT []
xref: Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K"
xref: Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3"
xref: Reactome:R-HSA-9028519 "NTRK2-activated PI3K generates PIP3"
+xref: Reactome:R-HSA-9670433 "KIT mutants:PI3K catalyze synthesis of PIP3"
xref: Wikipedia:Phosphoinositide_3-kinase
is_a: GO:0016301 ! kinase activity
relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation
@@ -213064,7 +213770,6 @@ id: GO:0035075
name: response to ecdysone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf]
-is_a: GO:0009725 ! response to hormone
is_a: GO:0036314 ! response to sterol
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
@@ -213200,8 +213905,7 @@ id: GO:0035094
name: response to nicotine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089]
-is_a: GO:0009636 ! response to toxic substance
-is_a: GO:0042493 ! response to drug
+is_a: GO:0042221 ! response to chemical
[Term]
id: GO:0035095
@@ -213267,6 +213971,8 @@ namespace: cellular_component
def: "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108]
synonym: "Facilitates chromatin transcription complex" EXACT []
is_a: GO:0008023 ! transcription elongation factor complex
+relationship: part_of GO:0000790 ! nuclear chromatin
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19572 xsd:anyURI
[Term]
id: GO:0035102
@@ -214563,7 +215269,6 @@ id: GO:0035240
name: dopamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732]
-is_a: GO:0008144 ! drug binding
is_a: GO:0043169 ! cation binding
is_a: GO:1901338 ! catecholamine binding
@@ -214589,7 +215294,7 @@ def: "Catalysis of the addition of a second methyl group to methylated peptidyl-
comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'.
synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming)" RELATED [EC:2.1.1.319]
synonym: "type I PRMT activity" RELATED []
-synonym: "type I protein arginine methyltransferase activity" RELATED [2.1.1.319]
+synonym: "type I protein arginine methyltransferase activity" RELATED [EC:2.1.1.319]
xref: EC:2.1.1.319
xref: RESID:AA0068
xref: RESID:AA0069
@@ -214875,7 +215580,6 @@ name: diphenyl phthalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com]
synonym: "DPP binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0097159 ! organic cyclic compound binding
[Term]
@@ -214885,7 +215589,6 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com]
synonym: "DBP binding" EXACT []
synonym: "phthalic acid dibutyl ester binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0097159 ! organic cyclic compound binding
[Term]
@@ -214893,7 +215596,6 @@ id: GO:0035276
name: ethanol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732]
-is_a: GO:0008144 ! drug binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043178 ! alcohol binding
@@ -215713,8 +216415,7 @@ namespace: biological_process
def: "The process in which flavin-adenine dinucleotide (FAD) is transported across a membrane. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [GOC:bf, ISBN:0198506732]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "FAD membrane transport" EXACT []
-is_a: GO:0015711 ! organic anion transport
-is_a: GO:0051181 ! cofactor transport
+is_a: GO:0015883 ! FAD transport
is_a: GO:0098656 ! anion transmembrane transport
is_a: GO:1901679 ! nucleotide transmembrane transport
created_by: bf
@@ -216046,8 +216747,8 @@ namespace: biological_process
def: "The process in which carbon dioxide (CO2) is transported across a membrane." [GOC:yaf]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "carbon dioxide membrane transport" EXACT []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015670 ! carbon dioxide transport
+is_a: GO:0055085 ! transmembrane transport
created_by: bf
creation_date: 2010-03-18T11:17:54Z
@@ -216692,7 +217393,6 @@ def: "Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dime
synonym: "3',5'-cyclic di-GMP binding" EXACT []
synonym: "c-di-GMP binding" EXACT []
synonym: "cyclic dinucleotide di-GMP binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0030551 ! cyclic nucleotide binding
is_a: GO:0032561 ! guanyl ribonucleotide binding
is_a: GO:0043168 ! anion binding
@@ -216782,7 +217482,6 @@ def: "The process in which borate is transported across a membrane. Borate is th
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "borate membrane transport" EXACT []
synonym: "boron transmembrane transport" RELATED []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0046713 ! borate transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
created_by: bf
@@ -216931,7 +217630,7 @@ creation_date: 2010-04-16T10:57:16Z
id: GO:0035456
name: response to interferon-beta
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374, PR:000008924]
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374]
synonym: "response to beta-1 interferon" RELATED [GOC:sl]
synonym: "response to fiblaferon" EXACT [GOC:sl]
synonym: "response to fibroblast interferon" EXACT [GOC:sl]
@@ -216944,7 +217643,7 @@ creation_date: 2010-04-16T11:06:12Z
id: GO:0035457
name: cellular response to interferon-alpha
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl, PR:000024938]
+def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl]
synonym: "cellular response to interferon alfa-n1" RELATED [GOC:sl]
synonym: "cellular response to interferon alfa-n3" RELATED [GOC:sl]
synonym: "cellular response to leukocyte interferon" EXACT [GOC:sl]
@@ -216959,7 +217658,7 @@ creation_date: 2010-04-16T11:08:29Z
id: GO:0035458
name: cellular response to interferon-beta
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PR:000024939]
+def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl]
synonym: "cellular response to beta-1 interferon" RELATED [GOC:sl]
synonym: "cellular response to fiblaferon" EXACT [GOC:sl]
synonym: "cellular response to fibroblast interferon" EXACT [GOC:sl]
@@ -217406,7 +218105,6 @@ def: "The chemical reactions and pathways involving the dipeptide beta-alanyl-L-
synonym: "carnosine metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0006575 ! cellular modified amino acid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
created_by: bf
creation_date: 2010-04-29T01:19:52Z
@@ -217796,8 +218494,12 @@ creation_date: 2010-05-07T10:21:15Z
id: GO:0035531
name: regulation of chemokine (C-C motif) ligand 6 production
namespace: biological_process
+alt_id: GO:0035534
+alt_id: GO:0035535
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf]
+synonym: "chemokine (C-C motif) ligand 6 secretion" NARROW []
synonym: "regulation of CCL6 production" EXACT []
+synonym: "regulation of chemokine (C-C motif) ligand 6 secretion" NARROW []
is_a: GO:0032642 ! regulation of chemokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production
@@ -217809,8 +218511,10 @@ creation_date: 2010-05-07T10:22:51Z
id: GO:0035532
name: negative regulation of chemokine (C-C motif) ligand 6 production
namespace: biological_process
+alt_id: GO:0035536
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf]
synonym: "negative regulation of CCL6 production" EXACT []
+synonym: "negative regulation of chemokine (C-C motif) ligand 6 secretion" NARROW []
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production
intersection_of: GO:0008150 ! biological_process
@@ -217823,8 +218527,10 @@ creation_date: 2010-05-07T10:23:40Z
id: GO:0035533
name: positive regulation of chemokine (C-C motif) ligand 6 production
namespace: biological_process
+alt_id: GO:0035537
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf]
synonym: "positive regulation of CCL6 production" EXACT []
+synonym: "positive regulation of chemokine (C-C motif) ligand 6 secretion" NARROW []
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production
intersection_of: GO:0008150 ! biological_process
@@ -217833,61 +218539,6 @@ relationship: positively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 p
created_by: bf
creation_date: 2010-05-07T10:24:21Z
-[Term]
-id: GO:0035534
-name: chemokine (C-C motif) ligand 6 secretion
-namespace: biological_process
-def: "The regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:amm]
-synonym: "CCL6 secretion" EXACT []
-is_a: GO:0090195 ! chemokine secretion
-relationship: part_of GO:0035530 ! chemokine (C-C motif) ligand 6 production
-created_by: bf
-creation_date: 2010-05-07T10:28:11Z
-
-[Term]
-id: GO:0035535
-name: regulation of chemokine (C-C motif) ligand 6 secretion
-namespace: biological_process
-def: "Any process that modulates the rate, frequency or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf]
-synonym: "regulation of CCL6 secretion" EXACT []
-is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production
-is_a: GO:0090196 ! regulation of chemokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
-relationship: regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
-created_by: bf
-creation_date: 2010-05-07T10:29:40Z
-
-[Term]
-id: GO:0035536
-name: negative regulation of chemokine (C-C motif) ligand 6 secretion
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf]
-synonym: "negative regulation of CCL6 secretion" EXACT []
-is_a: GO:0035532 ! negative regulation of chemokine (C-C motif) ligand 6 production
-is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion
-is_a: GO:0090198 ! negative regulation of chemokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
-relationship: negatively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
-created_by: bf
-creation_date: 2010-05-07T10:30:14Z
-
-[Term]
-id: GO:0035537
-name: positive regulation of chemokine (C-C motif) ligand 6 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf]
-synonym: "positive regulation of CCL6 secretion" EXACT []
-is_a: GO:0035533 ! positive regulation of chemokine (C-C motif) ligand 6 production
-is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion
-is_a: GO:0090197 ! positive regulation of chemokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
-relationship: positively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion
-created_by: bf
-creation_date: 2010-05-07T10:31:19Z
-
[Term]
id: GO:0035538
name: carbohydrate response element binding
@@ -217995,71 +218646,6 @@ relationship: part_of GO:0007399 ! nervous system development
created_by: bf
creation_date: 2010-05-11T01:53:33Z
-[Term]
-id: GO:0035546
-name: interferon-beta secretion
-namespace: biological_process
-def: "The regulated release of interferon-beta from a cell." [GOC:add, GOC:bf]
-synonym: "IFN-beta secretion" EXACT []
-synonym: "IFNB secretion" EXACT [GOC:mah]
-is_a: GO:0072641 ! type I interferon secretion
-relationship: part_of GO:0032608 ! interferon-beta production
-created_by: bf
-creation_date: 2010-05-12T10:04:11Z
-
-[Term]
-id: GO:0035547
-name: regulation of interferon-beta secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf]
-synonym: "regulation of IFN-beta secretion" EXACT []
-is_a: GO:0032648 ! regulation of interferon-beta production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0035546 ! interferon-beta secretion
-relationship: regulates GO:0035546 ! interferon-beta secretion
-created_by: bf
-creation_date: 2010-05-12T10:06:03Z
-
-[Term]
-id: GO:0035548
-name: negative regulation of interferon-beta secretion
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf]
-synonym: "down regulation of interferon-beta secretion" EXACT []
-synonym: "down-regulation of interferon-beta secretion" EXACT []
-synonym: "downregulation of interferon-beta secretion" EXACT []
-synonym: "inhibition of interferon-beta secretion" NARROW []
-synonym: "negative regulation of IFN-beta secretion" EXACT []
-is_a: GO:0032688 ! negative regulation of interferon-beta production
-is_a: GO:0035547 ! regulation of interferon-beta secretion
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0035546 ! interferon-beta secretion
-relationship: negatively_regulates GO:0035546 ! interferon-beta secretion
-created_by: bf
-creation_date: 2010-05-12T10:06:28Z
-
-[Term]
-id: GO:0035549
-name: positive regulation of interferon-beta secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf]
-synonym: "activation of interferon-beta secretion" NARROW []
-synonym: "positive regulation of IFN-beta secretion" EXACT []
-synonym: "stimulation of interferon-beta secretion" NARROW []
-synonym: "up regulation of interferon-beta secretion" EXACT []
-synonym: "up-regulation of interferon-beta secretion" EXACT []
-synonym: "upregulation of interferon-beta secretion" EXACT []
-is_a: GO:0032728 ! positive regulation of interferon-beta production
-is_a: GO:0035547 ! regulation of interferon-beta secretion
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0035546 ! interferon-beta secretion
-relationship: positively_regulates GO:0035546 ! interferon-beta secretion
-created_by: bf
-creation_date: 2010-05-12T10:06:50Z
-
[Term]
id: GO:0035550
name: urease complex
@@ -220347,6 +220933,7 @@ namespace: biological_process
def: "The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:10639460]
synonym: "migration in host through an epithelial cell layer" EXACT [GOC:bf]
synonym: "migration of symbiont within host by transepithelial trafficking" EXACT [GOC:bf]
+synonym: "transmigration of symbiont in host" RELATED []
is_a: GO:0044001 ! migration in host
created_by: bf
creation_date: 2011-03-24T10:20:03Z
@@ -220713,7 +221300,7 @@ creation_date: 2011-04-06T10:45:15Z
id: GO:0035790
name: platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:yaf, PMID:10372961, PR:000002030]
+def: "A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:yaf, PMID:10372961]
synonym: "alphaPDGF receptor signaling pathway" EXACT [PMID:10372961]
synonym: "PDGF receptor-alpha signaling pathway" EXACT [GOC:bf]
synonym: "PDGFR-alpha signaling pathway" RELATED [GOC:bf]
@@ -220726,7 +221313,7 @@ creation_date: 2011-04-06T10:55:16Z
id: GO:0035791
name: platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961, PR:000002035]
+def: "A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961]
synonym: "betaPDGF receptor signaling pathway" EXACT [PMID:10372961]
synonym: "PDGF receptor-beta signaling pathway" EXACT [GOC:bf]
synonym: "PDGFR-beta signaling pathway" EXACT [GOC:bf]
@@ -221854,16 +222441,18 @@ name: exochitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293, PMID:16298970, PMID:21390509]
xref: MetaCyc:RXN-12309
+xref: RHEA:50672
is_a: GO:0004568 ! chitinase activity
created_by: bf
creation_date: 2011-06-08T11:13:58Z
[Term]
id: GO:0035886
-name: vascular smooth muscle cell differentiation
+name: vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954]
synonym: "vascular associated smooth muscle cell differentiation" EXACT [CL:0000359]
+synonym: "vascular smooth muscle cell differentiation" EXACT []
synonym: "VSMC differentiation" EXACT [PMID:16151017]
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0001944 ! vasculature development
@@ -221875,7 +222464,7 @@ id: GO:0035887
name: aortic smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl]
-is_a: GO:0035886 ! vascular smooth muscle cell differentiation
+is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation
created_by: bf
creation_date: 2011-06-08T11:34:26Z
@@ -222000,7 +222589,7 @@ creation_date: 2011-06-15T03:00:27Z
id: GO:0035898
name: parathyroid hormone secretion
namespace: biological_process
-def: "The regulated release of parathyroid hormone into the circulatory system." [GOC:cjm, PMID:12171519, PMID:21164021, PR:000013429]
+def: "The regulated release of parathyroid hormone into the circulatory system." [GOC:cjm, PMID:12171519, PMID:21164021]
synonym: "parathormone secretion" EXACT [PR:000013429]
synonym: "parathyrin secretion" EXACT [PR:000013429]
synonym: "PTH secretion" EXACT [PMID:12171519, PR:000013429]
@@ -222283,7 +222872,6 @@ name: flurbiprofen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with flurbiprofen." [GOC:BHF, GOC:rl]
synonym: "2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
created_by: bf
@@ -222313,17 +222901,6 @@ is_a: GO:0017091 ! AU-rich element binding
created_by: bf
creation_date: 2011-07-19T09:30:18Z
-[Term]
-id: GO:0035926
-name: chemokine (C-C motif) ligand 2 secretion
-namespace: biological_process
-def: "The regulated release of chemokine (C-C motif) ligand 2 (CCL2) from a cell." [PMID:21501162]
-synonym: "CCL2 secretion" EXACT [GOC:bf]
-is_a: GO:0090195 ! chemokine secretion
-relationship: part_of GO:0072567 ! chemokine (C-X-C motif) ligand 2 production
-created_by: bf
-creation_date: 2011-07-19T09:33:54Z
-
[Term]
id: GO:0035927
name: RNA import into mitochondrion
@@ -222508,7 +223085,6 @@ def: "The regulated release of estrone into the circulatory system." [GOC:sl, PM
synonym: "3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT []
synonym: "folliculin secretion" EXACT []
is_a: GO:0015850 ! organic hydroxy compound transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0046879 ! hormone secretion
is_a: GO:0140353 ! lipid export from cell
created_by: bf
@@ -222518,7 +223094,7 @@ creation_date: 2011-07-25T02:18:40Z
id: GO:0035944
name: perforin production
namespace: biological_process
-def: "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000003466]
+def: "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: bf
creation_date: 2011-07-27T11:44:21Z
@@ -223146,8 +223722,6 @@ name: nitric oxide sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)." [GOC:kmv, PMID:21491957]
synonym: "NO sensor activity" EXACT []
-is_a: GO:0008144 ! drug binding
-is_a: GO:0042165 ! neurotransmitter binding
is_a: GO:0070026 ! nitric oxide binding
is_a: GO:0140299 ! small molecule sensor activity
relationship: part_of GO:0071731 ! response to nitric oxide
@@ -223230,7 +223804,6 @@ xref: UniPathway:UPA00848
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0051066 ! dihydrobiopterin metabolic process
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0090407 ! organophosphate biosynthetic process
created_by: bf
creation_date: 2011-09-02T01:15:35Z
@@ -223419,7 +223992,7 @@ creation_date: 2011-10-10T02:12:28Z
id: GO:0036015
name: response to interleukin-3
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387]
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf]
synonym: "response to IL-3" EXACT [GOC:bf]
is_a: GO:0034097 ! response to cytokine
created_by: bf
@@ -223429,7 +224002,7 @@ creation_date: 2011-10-12T10:08:26Z
id: GO:0036016
name: cellular response to interleukin-3
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387]
+def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf]
synonym: "cellular response to IL-3" EXACT [GOC:bf]
is_a: GO:0036015 ! response to interleukin-3
is_a: GO:0071345 ! cellular response to cytokine stimulus
@@ -223440,7 +224013,7 @@ creation_date: 2011-10-12T10:09:10Z
id: GO:0036017
name: response to erythropoietin
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis." [GOC:yaf, PR:000007141]
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis." [GOC:yaf]
is_a: GO:0034097 ! response to cytokine
created_by: bf
creation_date: 2011-10-12T10:11:04Z
@@ -223449,7 +224022,7 @@ creation_date: 2011-10-12T10:11:04Z
id: GO:0036018
name: cellular response to erythropoietin
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus." [GOC:yaf, PR:000007141]
+def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus." [GOC:yaf]
is_a: GO:0036017 ! response to erythropoietin
is_a: GO:0071345 ! cellular response to cytokine stimulus
created_by: bf
@@ -223716,7 +224289,6 @@ synonym: "diferuloylmethane metabolic process" EXACT [GOC:obol]
synonym: "diferuloylmethane metabolism" EXACT [GOC:obol]
synonym: "turmeric yellow metabolic process" EXACT [GOC:obol]
synonym: "turmeric yellow metabolism" EXACT [GOC:obol]
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
@@ -223743,11 +224315,9 @@ synonym: "turmeric yellow breakdown" EXACT [GOC:obol]
synonym: "turmeric yellow catabolic process" EXACT [GOC:obol]
synonym: "turmeric yellow catabolism" EXACT [GOC:obol]
synonym: "turmeric yellow degradation" EXACT [GOC:obol]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0036039 ! curcumin metabolic process
is_a: GO:0042182 ! ketone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: bf
creation_date: 2011-11-22T02:01:05Z
@@ -223766,7 +224336,8 @@ creation_date: 2011-11-24T02:54:39Z
id: GO:0036042
name: long-chain fatty acyl-CoA binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [GOC:pm]
+def: "Interacting selectively and non-covalently with a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [GOC:krc, GOC:pm]
+synonym: "long-chain fatty acyl-coenyme A binding" EXACT []
is_a: GO:0000062 ! fatty-acyl-CoA binding
created_by: bf
creation_date: 2011-11-24T04:31:09Z
@@ -223801,7 +224372,6 @@ def: "OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine t
comment: This term was made obsolete because it accidentally reused an exisiting id. See replacement term GO:0044392.
synonym: "lysine malonylation" EXACT [PMID:21908771]
synonym: "peptidyl-lysine malonylation" EXACT []
-xref: RESID:AA0568
is_obsolete: true
replaced_by: GO:0044392
created_by: bf
@@ -224268,7 +224838,6 @@ synonym: "D-serine catabolism" EXACT [GOC:bf]
synonym: "D-serine degradation" EXACT [GOC:bf]
is_a: GO:0009071 ! serine family amino acid catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0070178 ! D-serine metabolic process
created_by: bf
creation_date: 2012-01-06T10:58:51Z
@@ -224539,7 +225108,6 @@ synonym: "ALA metabolism" EXACT [CHEBI:27432]
synonym: "alpha-linolenic acid metabolism" EXACT [GOC:bf]
xref: Wikipedia:Linoleic_acid
is_a: GO:0001676 ! long-chain fatty acid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process
created_by: bf
creation_date: 2012-02-15T10:16:42Z
@@ -224609,7 +225177,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of a fatty-
synonym: "fatty-acyl-CoA breakdown" EXACT [GOC:bf]
synonym: "fatty-acyl-CoA catabolism" EXACT [GOC:bf]
synonym: "fatty-acyl-CoA degradation" EXACT [GOC:bf]
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
@@ -224695,7 +225262,7 @@ creation_date: 2012-02-20T02:53:51Z
id: GO:0036122
name: BMP binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951, PR:000000034]
+def: "Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951]
synonym: "bone morphogenetic protein binding" EXACT [GOC:bf]
is_a: GO:0019955 ! cytokine binding
created_by: bf
@@ -224787,6 +225354,7 @@ synonym: "PGH2 9,11-endoperoxidase" EXACT [PMID:12664595]
synonym: "PGH2 9-,11-endoperoxide reductase" EXACT [PMID:12432932]
xref: KEGG_REACTION:R02264
xref: Reactome:R-HSA-2161549 "PGH2 is reduced to PGF2a by AKR1C3"
+xref: RHEA:45312
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
relationship: part_of GO:0006693 ! prostaglandin metabolic process
created_by: bf
@@ -224802,6 +225370,7 @@ synonym: "prostaglandin 11-keto reductase" EXACT [PMID:7248318]
xref: EC:1.1.1.188
xref: KEGG_REACTION:R02799
xref: Reactome:R-HSA-2161614 "PGD2 is reduced to 11-epi-PGF2a by AKRIC3"
+xref: RHEA:45316
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
relationship: part_of GO:0006693 ! prostaglandin metabolic process
created_by: bf
@@ -224837,6 +225406,7 @@ comment: Note that the KEGG_REACTION:R05060 reaction does not stipulate the acce
synonym: "NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity" EXACT [PMID:1632314]
xref: KEGG_REACTION:R05060
xref: Reactome:R-HSA-2161732 "TXB2 is converted to 11dh-TXB2 by TXDH"
+xref: RHEA:52312
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: bf
creation_date: 2012-03-05T11:05:09Z
@@ -224848,6 +225418,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)." [GOC:mw, PMID:11297515]
synonym: "prostaglandin H2 degradation activity" RELATED [GOC:mw]
xref: Reactome:R-HSA-2161613 "PGH2 is degraded to 12S-HHT and MDA by TBXAS1"
+xref: RHEA:48644
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
created_by: bf
creation_date: 2012-03-05T11:17:34Z
@@ -225094,8 +225665,7 @@ creation_date: 2012-03-26T01:16:55Z
id: GO:0036161
name: calcitonin secretion
namespace: biological_process
-def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm, PR:000027222]
-is_a: GO:0015893 ! drug transport
+def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm]
is_a: GO:0030072 ! peptide hormone secretion
created_by: bf
creation_date: 2012-03-26T01:30:32Z
@@ -225105,7 +225675,6 @@ id: GO:0036162
name: oxytocin secretion
namespace: biological_process
def: "The regulated release of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain, from a cell. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior." [GOC:cjm, Wikipedia:Oxytocin]
-is_a: GO:0015893 ! drug transport
is_a: GO:0030072 ! peptide hormone secretion
created_by: bf
creation_date: 2012-03-26T01:43:46Z
@@ -225116,6 +225685,7 @@ name: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2." [GOC:mw, KEGG_REACTION:R06866, PMID:620805, PMID:7028108]
xref: KEGG_REACTION:R06866
+xref: RHEA:44768
is_a: GO:0016831 ! carboxy-lyase activity
created_by: bf
creation_date: 2012-03-26T01:49:54Z
@@ -225725,7 +226295,7 @@ creation_date: 2012-04-26T02:58:50Z
id: GO:0036215
name: response to stem cell factor
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PR:000009345]
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh]
synonym: "response to hematopoietic growth factor KL" EXACT [PR:000009345]
synonym: "response to KIT ligand" EXACT [PR:000009345]
synonym: "response to SCF" EXACT [PR:000009345]
@@ -225738,7 +226308,7 @@ creation_date: 2012-04-27T10:26:37Z
id: GO:0036216
name: cellular response to stem cell factor stimulus
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PMID:18787413, PMID:7520444, PR:000009345]
+def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PMID:18787413, PMID:7520444]
synonym: "cellular response to hematopoietic growth factor KL" EXACT [PR:000009345]
synonym: "cellular response to KIT ligand" EXACT [PR:000009345]
synonym: "cellular response to KITLG" EXACT [PMID:18787413]
@@ -225987,7 +226557,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of glutamat
comment: In the catabolism of glutamate in mammals, succinate semialdehyde is converted to succinate (see GO:0006540). Plants can utilize an alternative route, converting succinic semialdehyde to 4-hydroxybutyrate using gamma-hydroxybutyrate dehydrogenase.
synonym: "glutamate degradation to 4-hydroxybutyrate" EXACT [MetaCyc:PWY-4321]
is_a: GO:0006538 ! glutamate catabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046459 ! short-chain fatty acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
relationship: has_part GO:0047577 ! 4-hydroxybutyrate dehydrogenase activity
@@ -226012,12 +226581,14 @@ creation_date: 2012-05-23T02:28:33Z
id: GO:0036243
name: succinate-semialdehyde dehydrogenase (NADP+) activity
namespace: molecular_function
-def: "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+." [EC:1.2.1.79, GOC:bf]
+def: "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+." [GOC:bf, RHEA:13213]
comment: This function is similar to EC:1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC:1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+.
synonym: "NADP-dependent succinate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.79]
synonym: "succinate semialdehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.79]
synonym: "succinic semialdehyde dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.79]
synonym: "succinyl semialdehyde dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.79]
+xref: EC:1.2.1.79
+xref: RHEA:13213
is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity
created_by: bf
creation_date: 2012-05-23T02:47:52Z
@@ -226038,7 +226609,6 @@ name: cellular response to menadione
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [GOC:al, Wikipedia:Menadione]
synonym: "cellular response to vitamin K3" EXACT [GOC:al]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901655 ! cellular response to ketone
created_by: bf
@@ -226100,11 +226670,12 @@ creation_date: 2012-05-31T03:09:09Z
[Term]
id: GO:0036251
-name: positive regulation of transcription from RNA polymerase II promoter in response to salt stress
+name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
-def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:al]
-is_a: GO:0061393 ! positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
-is_a: GO:0061416 ! regulation of transcription from RNA polymerase II promoter in response to salt stress
+def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:al]
+comment: This term was obsoleted because it represents a GO-CAM model.
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI
+is_obsolete: true
created_by: bf
creation_date: 2012-06-12T11:38:22Z
@@ -226127,7 +226698,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0036270 ! response to diuretic
created_by: bf
creation_date: 2012-06-15T01:05:35Z
@@ -226136,7 +226706,6 @@ id: GO:0036254
name: cellular response to amiloride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0036253 ! response to amiloride
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
@@ -226228,7 +226797,7 @@ creation_date: 2012-06-15T02:21:39Z
id: GO:0036262
name: granulysin production
namespace: biological_process
-def: "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000008119]
+def: "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]
is_a: GO:0002440 ! production of molecular mediator of immune response
created_by: bf
creation_date: 2012-06-18T02:11:15Z
@@ -226323,7 +226892,6 @@ subset: gocheck_do_not_manually_annotate
synonym: "response to MPD" EXACT [CHEBI:6887]
synonym: "response to MPH" EXACT [CHEBI:6887]
synonym: "response to ritalin" EXACT [CHEBI:6887]
-is_a: GO:0042493 ! response to drug
is_a: GO:1901698 ! response to nitrogen compound
created_by: bf
creation_date: 2012-07-09T01:30:57Z
@@ -226337,12 +226905,8 @@ comment: Note that this term is in the subset of terms that should not be used f
subset: gocheck_do_not_manually_annotate
synonym: "response to 2',2'-difluorodeoxycytidine" EXACT [CHEBI:175901]
synonym: "response to 2'-deoxy-2',2'-difluorocytidine" EXACT [CHEBI:175901]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097327 ! response to antineoplastic agent
-is_a: GO:0097329 ! response to antimetabolite
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: bf
creation_date: 2012-07-09T01:36:03Z
@@ -226357,7 +226921,6 @@ subset: gocheck_do_not_manually_annotate
synonym: "response to HMG-CoA reductase inhibitor" RELATED [CHEBI:35664]
synonym: "response to hydroxymethylglutaryl-CoA reductase inhibitor" RELATED [CHEBI:35664]
is_a: GO:0010033 ! response to organic substance
-is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: bf
creation_date: 2012-07-09T01:54:01Z
@@ -226371,7 +226934,6 @@ comment: Note that this term is in the subset of terms that should not be used f
subset: gocheck_do_not_manually_annotate
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: bf
creation_date: 2012-07-09T02:02:26Z
@@ -226385,10 +226947,7 @@ comment: Note that this term is in the subset of terms that should not be used f
subset: gocheck_do_not_manually_annotate
synonym: "response to 5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT [CHEBI:46345]
synonym: "response to fluorouracil" EXACT [GOC:hp]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097327 ! response to antineoplastic agent
-is_a: GO:0097329 ! response to antimetabolite
created_by: bf
creation_date: 2012-07-09T02:08:23Z
@@ -226442,7 +227001,6 @@ name: cellular response to L-canavanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group." [GOC:al]
is_a: GO:0071230 ! cellular response to amino acid stimulus
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1901354 ! response to L-canavanine
created_by: bf
creation_date: 2012-07-11T11:09:37Z
@@ -226514,7 +227072,6 @@ subset: gocheck_do_not_manually_annotate
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
is_a: GO:0071867 ! response to monoamine
-is_a: GO:0097332 ! response to antipsychotic drug
is_a: GO:1901654 ! response to ketone
created_by: bf
creation_date: 2012-07-16T05:01:29Z
@@ -226528,7 +227085,6 @@ comment: Note that this term is in the subset of terms that should not be used f
subset: gocheck_do_not_manually_annotate
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0061476 ! response to anticoagulant
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: bf
creation_date: 2012-07-16T05:03:56Z
@@ -226766,12 +227322,10 @@ def: "Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to
synonym: "annealing activity" BROAD [GOC:bf]
synonym: "ATP-dependent DNA annealing activity" RELATED [GOC:sp]
synonym: "nucleoside-triphosphatase activity involved in DNA annealing" EXACT [GOC:bf]
-is_a: GO:0017111 ! nucleoside-triphosphatase activity
is_a: GO:0097617 ! annealing activity
-is_a: GO:0140097 ! catalytic activity, acting on DNA
-intersection_of: GO:0017111 ! nucleoside-triphosphatase activity
-intersection_of: part_of GO:0000733 ! DNA strand renaturation
+relationship: has_part GO:0016887 ! ATPase activity
relationship: part_of GO:0000733 ! DNA strand renaturation
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19669 xsd:anyURI
created_by: bf
creation_date: 2012-08-14T15:24:29Z
@@ -226886,8 +227440,8 @@ creation_date: 2012-08-30T16:51:12Z
id: GO:0036320
name: mating-type P-factor pheromone receptor activity
namespace: molecular_function
-def: "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [GOC:al, PMID:8314086, PMID:886120]
-synonym: "P-factor mating pheromone receptor activity" EXACT [2]
+def: "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [GOC:al, PMID:8314086]
+synonym: "P-factor mating pheromone receptor activity" EXACT []
synonym: "P-factor receptor activity" EXACT []
is_a: GO:0004932 ! mating-type factor pheromone receptor activity
is_a: GO:0036318 ! peptide pheromone receptor activity
@@ -226900,7 +227454,6 @@ name: ghrelin secretion
namespace: biological_process
def: "The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone." [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin]
synonym: "pancreatic ghrelin secretion" NARROW [GOC:cjm]
-is_a: GO:0015893 ! drug transport
is_a: GO:0030072 ! peptide hormone secretion
created_by: bf
creation_date: 2012-09-04T14:16:43Z
@@ -226919,7 +227472,7 @@ creation_date: 2012-09-04T14:39:03Z
id: GO:0036323
name: vascular endothelial growth factor receptor-1 signaling pathway
namespace: biological_process
-def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007563, Wikipedia:FLT1, Wikipedia:VEGF_receptors]
+def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, Wikipedia:FLT1, Wikipedia:VEGF_receptors]
synonym: "FLT1 signaling pathway" EXACT [GOC:uh, PR:000007563]
synonym: "VEGFR-1 signaling pathway" EXACT [PR:000007563, Reactome:R-HSA-194311, Wikipedia:VEGF_receptors]
synonym: "VEGFR1 signaling pathway" EXACT [Reactome:R-HSA-194311]
@@ -226931,7 +227484,7 @@ creation_date: 2012-09-04T15:11:21Z
id: GO:0036324
name: vascular endothelial growth factor receptor-2 signaling pathway
namespace: biological_process
-def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:12967471, PR:000002112, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]
+def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:12967471, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]
synonym: "FLK-1 signaling pathway" EXACT [PR:000002112]
synonym: "KDR signaling pathway" EXACT [GOC:uh, PR:000002112, Wikipedia:Kinase_insert_domain_receptor]
synonym: "VEGFR-2 signaling pathway" EXACT [PR:000002112, Reactome:R-HSA-194310, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]
@@ -226944,7 +227497,7 @@ creation_date: 2012-09-04T15:15:40Z
id: GO:0036325
name: vascular endothelial growth factor receptor-3 signaling pathway
namespace: biological_process
-def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007565, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3]
+def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3]
synonym: "FLT4 signaling pathway" EXACT [GOC:uh, PR:000007565]
synonym: "VEGFR-3 signaling pathway" EXACT [Reactome:R-HSA-194308, Wikipedia:VEGF_receptors]
synonym: "VEGFR3 signaling pathway" EXACT [Reactome:R-HSA-194310, Wikipedia:VEGFR3]
@@ -226956,8 +227509,8 @@ creation_date: 2012-09-04T15:25:13Z
id: GO:0036326
name: VEGF-A-activated receptor activity
namespace: molecular_function
-def: "Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017284, Wikipedia:VEGF-A]
-synonym: "vascular endothelial growth factor A-activated receptor activity" EXACT [GOC:bf, PR:000017284]
+def: "Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, Wikipedia:VEGF-A]
+synonym: "vascular endothelial growth factor A-activated receptor activity" EXACT [GOC:bf]
is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity
created_by: bf
creation_date: 2012-09-04T15:33:19Z
@@ -226966,7 +227519,7 @@ creation_date: 2012-09-04T15:33:19Z
id: GO:0036327
name: VEGF-B-activated receptor activity
namespace: molecular_function
-def: "Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000003096, Wikipedia:VEGF-B]
+def: "Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, Wikipedia:VEGF-B]
synonym: "vascular endothelial growth factor B-activated receptor activity" EXACT [GOC:bf, PR:000003096]
is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity
created_by: bf
@@ -226976,7 +227529,7 @@ creation_date: 2012-09-04T15:36:05Z
id: GO:0036328
name: VEGF-C-activated receptor activity
namespace: molecular_function
-def: "Combining with vascular endothelial growth factor C (VEGF-C) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017285, Wikipedia:VEGF-C]
+def: "Combining with vascular endothelial growth factor C (VEGF-C) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, Wikipedia:VEGF-C]
synonym: "vascular endothelial growth factor C-activated receptor activity" EXACT [GOC:bf, PR:000017285]
synonym: "VEGFC-activated receptor activity" EXACT [PR:000017285]
is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity
@@ -226987,7 +227540,7 @@ creation_date: 2012-09-04T15:37:17Z
id: GO:0036329
name: VEGF-D-activated receptor activity
namespace: molecular_function
-def: "Combining with vascular endothelial growth factor D (VEGF-D) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000007520, Wikipedia:VEGF-D]
+def: "Combining with vascular endothelial growth factor D (VEGF-D) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, Wikipedia:VEGF-D]
synonym: "C-fos induced growth factor receptor activity" EXACT [PR:000007520, Wikipedia:VEGF-D]
synonym: "vascular endothelial growth factor D-activated receptor activity" EXACT [GOC:bf, PR:000007520]
synonym: "VEGFD-activated receptor activity" EXACT [PR:000017285]
@@ -227020,7 +227573,7 @@ creation_date: 2012-09-05T09:07:14Z
id: GO:0036332
name: placental growth factor-activated receptor activity
namespace: molecular_function
-def: "Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:uh, PMID:12871269, PMID:7929268, PR:000012605, Wikipedia:Placental_growth_factor]
+def: "Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:uh, PMID:12871269, PMID:7929268, Wikipedia:Placental_growth_factor]
synonym: "placental growth factor receptor activity" EXACT [GOC:bf]
synonym: "PlGF receptor activity" RELATED [PMID:12871269]
synonym: "PlGF-activated receptor activity" EXACT [GOC:uh, PMID:12871269]
@@ -227177,6 +227730,7 @@ def: "Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstit
xref: EC:5.1.99.5
xref: KEGG_REACTION:R09704
xref: MetaCyc:RXN-9781
+xref: RHEA:46624
is_a: GO:0016854 ! racemase and epimerase activity
created_by: bf
creation_date: 2012-09-19T10:47:56Z
@@ -227241,6 +227795,7 @@ name: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+." [GOC:crds, InterPro:IPR005903, MetaCyc:RXN-8787, PMID:8437569]
xref: MetaCyc:RXN-8787
+xref: RHEA:19733
is_a: GO:0016491 ! oxidoreductase activity
relationship: part_of GO:0030494 ! bacteriochlorophyll biosynthetic process
created_by: bf
@@ -227507,6 +228062,7 @@ xref: Reactome:R-HSA-9026927 "GGT hydrolyses RCTR1 to RCTR2"
xref: Reactome:R-HSA-9035966 "Defective GGT1 does not hydrolyse GSH"
xref: RHEA:28807
is_a: GO:0008242 ! omega peptidase activity
+is_a: GO:0070003 ! threonine-type peptidase activity
created_by: bf
creation_date: 2013-05-07T09:58:07Z
@@ -227559,12 +228115,10 @@ synonym: "1alpha,25-dihydroxycholecalciferol biosynthesis" BROAD [CHEBI:17823]
synonym: "1alpha,25-dihydroxyvitamin D3 biosynthesis" BROAD [CHEBI:17823]
synonym: "calcitriol biosynthesis from calciol" EXACT [GOC:bf]
synonym: "vitamin D3 activation" EXACT [GOC:bf, PMID:20506379]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0042368 ! vitamin D biosynthetic process
is_a: GO:0044108 ! cellular alcohol biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:0070640 ! vitamin D3 metabolic process
-is_a: GO:0120178 ! steroid hormone biosynthetic process
created_by: bf
creation_date: 2013-05-15T11:46:08Z
@@ -227622,6 +228176,7 @@ synonym: "NADH-dependent flavin reductase activity" EXACT [EC:1.5.1.36]
xref: EC:1.5.1.36
xref: KEGG_REACTION:R09662
xref: MetaCyc:1.5.1.36-RXN
+xref: RHEA:31303
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
created_by: bf
creation_date: 2013-05-23T11:23:09Z
@@ -228164,10 +228719,9 @@ creation_date: 2013-09-16T13:02:43Z
id: GO:0036426
name: ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP." [RHEA:28118]
+def: "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP." [GOC:curators]
xref: KEGG_REACTION:R07257
xref: MetaCyc:2.4.1.54-RXN
-xref: RHEA:28118
is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity
created_by: bf
creation_date: 2013-09-16T13:21:01Z
@@ -228176,8 +228730,8 @@ creation_date: 2013-09-16T13:21:01Z
id: GO:0036427
name: all-trans-undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [RHEA:12784]
-xref: RHEA:12784
+def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [RHEA:28118]
+xref: RHEA:28118
is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity
created_by: bf
creation_date: 2013-09-16T13:23:06Z
@@ -228488,71 +229042,12 @@ creation_date: 2013-12-09T13:04:09Z
id: GO:0036458
name: hepatocyte growth factor binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with a hepatocyte growth factor." [PR:000008534]
+def: "Interacting selectively and non-covalently with a hepatocyte growth factor." [GOC:curators]
synonym: "HGF binding" EXACT [PR:000008534]
is_a: GO:0019838 ! growth factor binding
created_by: bf
creation_date: 2013-12-09T14:07:20Z
-[Term]
-id: GO:0036459
-name: thiol-dependent ubiquitinyl hydrolase activity
-namespace: molecular_function
-def: "Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin." [EC:3.4.19.12, GOC:bf, GOC:ka]
-comment: 20160208: Renamed to thiol-dependent ubiquitinyl hydrolase activity
-synonym: "ubiquitin C-terminal hydrolase" EXACT [EC:3.4.19.12]
-synonym: "ubiquitinyl hydrolase 1 activity" EXACT [EC:3.4.19.12]
-synonym: "ubiquitinyl hydrolase activity" BROAD []
-xref: EC:3.4.19.12
-xref: Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2"
-xref: Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains"
-xref: Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2"
-xref: Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN"
-xref: Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4"
-xref: Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53"
-xref: Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B"
-xref: Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin"
-xref: Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A"
-xref: Reactome:R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58"
-xref: Reactome:R-HSA-5690196 "USP8 deubiquitinates RNF128"
-xref: Reactome:R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts"
-xref: Reactome:R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1"
-xref: Reactome:R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex"
-xref: Reactome:R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A"
-xref: Reactome:R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1"
-xref: Reactome:R-HSA-5696564 "USP25 deubiquitinates DDX58"
-xref: Reactome:R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1"
-xref: Reactome:R-HSA-5696605 "USP12, USP26 deubiquitinate AR"
-xref: Reactome:R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG"
-xref: Reactome:R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins"
-xref: Reactome:R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC"
-xref: Reactome:R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB"
-xref: Reactome:R-HSA-5696947 "USP47 deubiquitinates POLB"
-xref: Reactome:R-HSA-5696958 "USP44 deubiquitinates CDC20"
-xref: Reactome:R-HSA-5696960 "USP49 deubiquitinates H2B"
-xref: Reactome:R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2"
-xref: Reactome:R-HSA-5696997 "USP24 deubiquitinates DDB2"
-xref: Reactome:R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2"
-xref: Reactome:R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1"
-xref: Reactome:R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10"
-xref: Reactome:R-HSA-6781814 "USP19 deubiquitinates RNF123"
-xref: Reactome:R-HSA-6781897 "USP11 deubiquitinates NFKBIA"
-xref: Reactome:R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR"
-xref: Reactome:R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS"
-xref: Reactome:R-HSA-6782820 "USP17 deubiquitinates SUDS3"
-xref: Reactome:R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33"
-xref: Reactome:R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4"
-xref: Reactome:R-HSA-8862184 "USP48 cleaves polyubiquitin"
-xref: Reactome:R-HSA-8865182 "OTUD7A hydrolyses K11diUb"
-xref: Reactome:R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6"
-xref: Reactome:R-HSA-8873946 "OTUD3 deubiquitinates PTEN"
-xref: Reactome:R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin"
-xref: Reactome:R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin"
-is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity
-is_a: GO:0101005 ! ubiquitinyl hydrolase activity
-created_by: bf
-creation_date: 2013-12-19T09:39:38Z
-
[Term]
id: GO:0036460
name: cellular response to cell envelope stress
@@ -229039,7 +229534,7 @@ creation_date: 2015-02-05T13:12:12Z
id: GO:0036499
name: PERK-mediated unfolded protein response
namespace: biological_process
-def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210]
+def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210, PMID:27629041]
synonym: "EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255]
synonym: "endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:bf]
synonym: "eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response" RELATED [HGNC:3255]
@@ -229050,6 +229545,7 @@ synonym: "PKR-like ER kinase signal transduction" EXACT [PMID:22013210]
synonym: "UPR signaling by PERK stress sensor" EXACT [GOC:bf]
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response
+is_a: GO:0140467 ! integrated stress response signaling
created_by: bf
creation_date: 2015-02-05T13:17:43Z
@@ -229129,7 +229625,7 @@ creation_date: 2015-05-21T10:05:06Z
id: GO:0036505
name: prosaposin receptor activity
namespace: molecular_function
-def: "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)." [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493, PR:000031300]
+def: "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)." [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493]
synonym: "prosaposin-activated receptor activity" EXACT [GOC:bf]
is_a: GO:0004930 ! G protein-coupled receptor activity
created_by: bf
@@ -229370,8 +229866,11 @@ creation_date: 2016-06-06T14:53:54Z
id: GO:0036524
name: protein deglycase activity
namespace: molecular_function
-def: "Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein." [GOC:bf, GOC:PARL, MetaCyc:RXN-17630, MetaCyc:RXN-17632, MetaCyc:RXN-17634, PMID:14568004, PMID:25416785, PMID:26873906, RHEA:49548, RHEA:49552, RHEA:49556]
+def: "Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785, PMID:26873906]
synonym: "protein deglycating enzyme" RELATED [PMID:26873906]
+xref: MetaCyc:RXN-17630
+xref: MetaCyc:RXN-17632
+xref: MetaCyc:RXN-17634
is_a: GO:0016836 ! hydro-lyase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
relationship: part_of GO:0036525 ! protein deglycation
@@ -229763,6 +230262,8 @@ synonym: "endocytic receptor activity" NARROW [GOC:signaling, ISBN:0123645387, P
synonym: "receptor activity" BROAD []
synonym: "receptor activity involved in receptor-mediated endocytosis" NARROW [GOC:bf]
synonym: "transport receptor activity" BROAD [GOC:signaling]
+xref: Reactome:R-HSA-3000122 "CD320 transports extracellular TCII:Cbl to endosome"
+xref: Reactome:R-HSA-350168 "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D"
is_a: GO:0003674 ! molecular_function
relationship: has_part GO:0060090 ! molecular adaptor activity
relationship: part_of GO:0006897 ! endocytosis
@@ -229773,7 +230274,7 @@ creation_date: 2011-08-01T02:50:45Z
id: GO:0038025
name: reelin receptor activity
namespace: molecular_function
-def: "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879]
+def: "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:12827279, PMID:20223215]
synonym: "reeler receptor activity" EXACT [PR:000013879]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: part_of GO:0038026 ! reelin-mediated signaling pathway
@@ -229784,7 +230285,7 @@ creation_date: 2011-08-02T12:01:25Z
id: GO:0038026
name: reelin-mediated signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879]
+def: "A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12827279, PMID:20223215]
synonym: "reeler-mediated signaling pathway" EXACT [GOC:bf, PR:000013879]
synonym: "reelin-mediated signal transduction pathway" EXACT [GOC:bf]
synonym: "reelin-mediated signalling pathway" EXACT [GOC:bf]
@@ -229991,7 +230492,7 @@ creation_date: 2011-11-02T04:52:24Z
id: GO:0038043
name: interleukin-5-mediated signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:pg, GOC:signaling, PR:000001392]
+def: "A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]
synonym: "IL-5-mediated signaling pathway" EXACT [GOC:bf]
synonym: "interleukin-5-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
@@ -230078,7 +230579,7 @@ creation_date: 2011-11-29T04:29:42Z
id: GO:0038055
name: BMP secretion
namespace: biological_process
-def: "The controlled release of a member of the BMP family of proteins from a cell." [GOC:sart, PR:000000034]
+def: "The controlled release of a member of the BMP family of proteins from a cell." [GOC:sart]
synonym: "BMP protein secretion" EXACT [GOC:bf]
synonym: "bone morphogenetic protein secretion" EXACT [GOC:bf]
is_a: GO:0009306 ! protein secretion
@@ -230105,7 +230606,7 @@ creation_date: 2011-12-19T10:55:47Z
id: GO:0038057
name: TNFSF11 binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family." [GOC:cjm, PR:000002107]
+def: "Interacting selectively and non-covalently with tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family." [GOC:cjm]
synonym: "CD254 binding" EXACT [GOC:sl, PR:000002107]
synonym: "ODF binding" EXACT [GOC:sl, PR:000002107]
synonym: "OPGL binding" EXACT [GOC:sl, PR:000002107]
@@ -230126,7 +230627,7 @@ creation_date: 2012-01-04T03:25:59Z
id: GO:0038058
name: TNFSF11 receptor activity
namespace: molecular_function
-def: "Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function." [GOC:bf, GOC:cjm, PR:000002107]
+def: "Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function." [GOC:bf, GOC:cjm]
synonym: "RANKL receptor activity" EXACT [PR:000002107, Wikipedia:RANKL]
synonym: "tumor necrosis factor ligand superfamily member 11 receptor activity" EXACT [PR:000002107, Wikipedia:RANKL]
is_a: GO:0005031 ! tumor necrosis factor-activated receptor activity
@@ -230456,7 +230957,7 @@ creation_date: 2012-02-01T02:14:18Z
id: GO:0038084
name: vascular endothelial growth factor signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285]
+def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]
comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.
synonym: "vascular endothelial growth factor signalling pathway" EXACT [GOC:bf]
synonym: "VEGF signaling" EXACT [GOC:bf]
@@ -230470,7 +230971,7 @@ creation_date: 2012-02-01T02:27:32Z
id: GO:0038085
name: vascular endothelial growth factor binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with a vascular endothelial growth factor." [PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285]
+def: "Interacting selectively and non-covalently with a vascular endothelial growth factor." [PMID:17470632]
synonym: "VEGF binding" EXACT [GOC:bf]
is_a: GO:0019838 ! growth factor binding
created_by: bf
@@ -230526,7 +231027,7 @@ creation_date: 2012-02-01T03:10:16Z
id: GO:0038089
name: positive regulation of cell migration by vascular endothelial growth factor signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PR:000003096, PR:000017284, PR:000017285]
+def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling]
synonym: "positive regulation of cell migration by vascular endothelial growth factor signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of cell migration by VEGF signaling pathway" EXACT [GOC:bf]
synonym: "VEGF-A-induced cell migration" NARROW [PMID:17470632]
@@ -230671,7 +231172,7 @@ creation_date: 2012-02-17T11:16:40Z
id: GO:0038100
name: nodal binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily." [GOC:bf, PMID:20629020, PR:000000105]
+def: "Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily." [GOC:bf, PMID:20629020]
is_a: GO:0005515 ! protein binding
property_value: RO:0002161 NCBITaxon:4751
created_by: bf
@@ -230857,9 +231358,9 @@ creation_date: 2012-03-22T10:21:01Z
id: GO:0038115
name: chemokine (C-C motif) ligand 19 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001991]
+def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845]
comment: The C-C chemokine CCL19 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL19-activated CCR7 signaling pathway ; GO:0038119'.
-synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203]
+synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845]
synonym: "CCL19-mediated signaling pathway" EXACT [PMID:15059845]
synonym: "chemokine (C-C motif) ligand 19 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
@@ -230870,7 +231371,7 @@ creation_date: 2012-03-22T11:28:32Z
id: GO:0038116
name: chemokine (C-C motif) ligand 21 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001993]
+def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845]
comment: The C-C chemokine CCL21 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL21-activated CCR7 signaling pathway ; GO:0038120'.
synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203]
synonym: "CCL21-mediated signaling pathway" EXACT [PMID:15059845]
@@ -230883,7 +231384,7 @@ creation_date: 2012-03-22T11:30:47Z
id: GO:0038117
name: C-C motif chemokine 19 receptor activity
namespace: molecular_function
-def: "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001991]
+def: "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845]
synonym: "CCL19 receptor activity" RELATED [PMID:15059845]
is_a: GO:0016493 ! C-C chemokine receptor activity
relationship: has_part GO:0035757 ! chemokine (C-C motif) ligand 19 binding
@@ -230895,10 +231396,10 @@ creation_date: 2012-03-22T11:59:10Z
id: GO:0038118
name: C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:15059845, PMID:15778365, PR:000001203]
+def: "A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:15059845, PMID:15778365]
comment: This term was created to show the binding of cytokines to multiple receptor types, and vice-versa. Known agonists of chemokine receptor type 7 (CCR7) are C-C chemokines CCL19 and CCL21. Consider instead annotating to one of the child terms 'CCL19-activated CCR7 signaling pathway ; GO:0038119' and/or 'CCL21-activated CCR7 signaling pathway ; GO:0038120'.
synonym: "C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:mah]
-synonym: "CCR7 signaling pathway" RELATED [PR:000001203]
+synonym: "CCR7 signaling pathway" RELATED []
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: bf
creation_date: 2012-03-22T11:43:57Z
@@ -230907,7 +231408,7 @@ creation_date: 2012-03-22T11:43:57Z
id: GO:0038119
name: CCL19-activated CCR7 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203]
+def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845]
synonym: "CCL19-activated CCR7 signalling pathway" EXACT [GOC:mah]
is_a: GO:0038115 ! chemokine (C-C motif) ligand 19 signaling pathway
is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
@@ -230918,7 +231419,7 @@ creation_date: 2012-03-22T11:47:24Z
id: GO:0038120
name: CCL21-activated CCR7 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203]
+def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845]
synonym: "CCL21-activated CCR7 signalling pathway" EXACT [GOC:mah]
is_a: GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway
is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway
@@ -230929,8 +231430,8 @@ creation_date: 2012-03-22T11:47:24Z
id: GO:0038121
name: C-C motif chemokine 21 receptor activity
namespace: molecular_function
-def: "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001993]
-synonym: "CCL21 receptor activity" RELATED [PMID:15059845, PR:000001993]
+def: "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845]
+synonym: "CCL21 receptor activity" RELATED [PMID:15059845]
is_a: GO:0016493 ! C-C chemokine receptor activity
relationship: has_part GO:0035758 ! chemokine (C-C motif) ligand 21 binding
relationship: part_of GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway
@@ -230941,7 +231442,7 @@ creation_date: 2012-03-22T01:28:06Z
id: GO:0038122
name: C-C motif chemokine 5 receptor activity
namespace: molecular_function
-def: "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PR:000002094]
+def: "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling]
synonym: "CCL5 receptor activity" EXACT [PR:000002094]
synonym: "RANTES receptor activity" EXACT [GOC:bf]
synonym: "small inducible cytokine A5 receptor activity" EXACT [PR:000002094]
@@ -230977,7 +231478,7 @@ creation_date: 2012-03-23T10:29:09Z
id: GO:0038127
name: ERBB signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000001812, Wikipedia:ErbB]
+def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, Wikipedia:ErbB]
synonym: "EGF receptor family signaling pathway" EXACT [PMID:11597398]
synonym: "EGFR family signaling pathway" RELATED [PMID:11597398]
synonym: "ErbB signaling" EXACT [PMID:20933094, Wikipedia:ErbB]
@@ -230990,7 +231491,7 @@ creation_date: 2012-03-30T09:23:01Z
id: GO:0038128
name: ERBB2 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair." [GOC:jc, PMID:16460914, PR:000002082, Reactome:R-HSA-1227986]
+def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair." [GOC:jc, PMID:16460914, Reactome:R-HSA-1227986]
synonym: "ERBB2 signalling pathway" EXACT [GOC:mah]
synonym: "HER2 signaling pathway" EXACT [PR:000002082]
synonym: "NEU signaling" EXACT [Reactome:R-HSA-1227986]
@@ -231003,7 +231504,7 @@ creation_date: 2012-03-30T10:05:12Z
id: GO:0038129
name: ERBB3 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission." [GOC:jc, PMID:16460914, PR:000007159, Reactome:R-HSA-1247497]
+def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission." [GOC:jc, PMID:16460914, Reactome:R-HSA-1247497]
synonym: "ERBB3 signalling pathway" EXACT [GOC:mah]
synonym: "HER3 signaling pathway" EXACT [PR:000007159]
synonym: "receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [PR:000007159]
@@ -231015,7 +231516,7 @@ creation_date: 2012-03-30T10:42:28Z
id: GO:0038130
name: ERBB4 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000007160, Reactome:R-HSA-1236394]
+def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, Reactome:R-HSA-1236394]
synonym: "ERBB4 signalling pathway" EXACT [GOC:mah]
synonym: "HER4 signaling pathway" EXACT [PR:000007160]
synonym: "receptor tyrosine-protein kinase erbB-4 signaling pathway" EXACT [PR:000007160]
@@ -231188,7 +231689,7 @@ creation_date: 2012-03-30T02:24:01Z
id: GO:0038145
name: macrophage colony-stimulating factor signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, GOC:uh, PMID:12138890, PR:000005930, Wikipedia:Macrophage_colony-stimulating_factor]
+def: "A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, GOC:uh, PMID:12138890, Wikipedia:Macrophage_colony-stimulating_factor]
synonym: "M-CSF signaling pathway" EXACT [PMID:12138890]
synonym: "macrophage colony-stimulating factor signalling pathway" EXACT [GOC:bf]
is_a: GO:0019221 ! cytokine-mediated signaling pathway
@@ -231200,7 +231701,7 @@ creation_date: 2012-04-27T11:04:18Z
id: GO:0038146
name: chemokine (C-X-C motif) ligand 12 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000006066, Wikipedia:Stromal_cell-derived_factor-1]
+def: "A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, Wikipedia:Stromal_cell-derived_factor-1]
synonym: "CXCL12 signaling pathway" EXACT [GOC:bf]
synonym: "CXCL12-activated CXCR7 signaling pathway" NARROW [GOC:bf]
synonym: "SDF1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066]
@@ -231228,7 +231729,7 @@ creation_date: 2012-05-11T11:32:53Z
id: GO:0038148
name: chemokine (C-C motif) ligand 2 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000002122, Wikipedia:CCL2]
+def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, Wikipedia:CCL2]
synonym: "CCL2 signaling pathway" EXACT [GOC:bf]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: bf
@@ -231249,7 +231750,7 @@ creation_date: 2012-05-11T11:37:16Z
id: GO:0038150
name: C-C chemokine receptor CCR2 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001199]
+def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "C-C chemokine receptor type 2 signaling pathway" EXACT [PR:000001199]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
created_by: bf
@@ -231270,7 +231771,7 @@ creation_date: 2012-05-11T11:41:58Z
id: GO:0038152
name: C-C chemokine receptor CCR4 signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001200]
+def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]
synonym: "C-C chemokine receptor type 4 signaling pathway" EXACT [PR:000001200]
synonym: "chemokine receptor CCR4 signaling pathway" EXACT [GOC:bf]
is_a: GO:0070098 ! chemokine-mediated signaling pathway
@@ -231468,7 +231969,7 @@ creation_date: 2012-05-15T12:01:09Z
id: GO:0038169
name: somatostatin receptor signaling pathway
namespace: biological_process
-def: "The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:18006219, PMID:8769369, PR:000001555]
+def: "The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:18006219, PMID:8769369]
comment: In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'.
synonym: "SST receptor signaling pathway" EXACT [GOC:bf]
synonym: "SSTR signaling pathway" RELATED [GOC:bf]
@@ -231508,7 +232009,7 @@ creation_date: 2012-06-12T10:47:53Z
id: GO:0038172
name: interleukin-33-mediated signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001389]
+def: "A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling]
synonym: "IL-33-mediated signaling pathway" EXACT [GOC:bf]
synonym: "IL33 signaling pathway" EXACT [PR:000001389]
synonym: "interleukin-33 signaling pathway" RELATED [GOC:jc]
@@ -231521,7 +232022,7 @@ creation_date: 2012-06-12T10:57:35Z
id: GO:0038173
name: interleukin-17A-mediated signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001138]
+def: "A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling]
synonym: "IL-17A-mediated signaling pathway" EXACT [GOC:bf]
synonym: "IL17A signaling pathway" EXACT [PR:000001138, Wikipedia:IL17A]
synonym: "IL17a signaling pathway" EXACT [GOC:jc]
@@ -231535,7 +232036,7 @@ creation_date: 2012-06-12T10:59:01Z
id: GO:0038174
name: interleukin-17A receptor activity
namespace: molecular_function
-def: "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:jc, GOC:signaling, PR:000001138]
+def: "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:jc, GOC:signaling]
is_a: GO:0030368 ! interleukin-17 receptor activity
relationship: part_of GO:0038173 ! interleukin-17A-mediated signaling pathway
created_by: bf
@@ -231592,7 +232093,7 @@ creation_date: 2012-09-21T10:55:00Z
id: GO:0038179
name: neurotrophin signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, PR:000021998, Wikipedia:Neurotrophin]
+def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, Wikipedia:Neurotrophin]
comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
synonym: "neurotrophin receptor signaling pathway" EXACT [PMID:22333586]
is_a: GO:0007166 ! cell surface receptor signaling pathway
@@ -231604,7 +232105,7 @@ creation_date: 2013-03-27T17:22:44Z
id: GO:0038180
name: nerve growth factor signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:11520933, PR:000011194, Wikipedia:Nerve_growth_factor]
+def: "A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:11520933, Wikipedia:Nerve_growth_factor]
comment: Nerve growth factor (NGF) binds at least two classes of receptors: the p75 LNGFR (low-affinity nerve growth factor receptor) and TrkA, a transmembrane tyrosine kinase.
synonym: "nerve growth factor signalling pathway" EXACT [GOC:bf]
synonym: "NGF signaling pathway" EXACT [PR:000011194, Wikipedia:Nerve_growth_factor]
@@ -233244,12 +233745,16 @@ creation_date: 2012-05-02T03:04:55Z
[Term]
id: GO:0039585
-name: PKR signal transduction
+name: PKR-mediated signaling
namespace: biological_process
-def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR, an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation." [PMID:21204021, PMID:22102852, PMID:9843495, VZ:1576]
+def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK3), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation." [PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576]
+synonym: "EIF2AK3 signal transduction" EXACT []
+synonym: "EIF2AK3/PERK signaling" EXACT []
+synonym: "PKR signal transduction" EXACT []
synonym: "PKR signaling pathway" EXACT [PMID:22102852]
synonym: "signaling through PKR" EXACT [GOC:bf]
is_a: GO:0035556 ! intracellular signal transduction
+is_a: GO:0140467 ! integrated stress response signaling
created_by: bf
creation_date: 2012-05-02T04:15:10Z
@@ -234671,7 +235176,7 @@ creation_date: 2013-12-19T13:21:45Z
id: GO:0039713
name: viral factory
namespace: cellular_component
-def: "An intracellular compartment in a host cell which increases the efficiency of viral replication and/or assembly, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments." [PMID:22440839, VZ:1951]
+def: "An intracellular compartment in a host cell which increases the efficiency of viral replication, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments." [PMID:22440839, VZ:1951]
synonym: "virus factory" EXACT [PMID:22440839]
xref: VZ:1951 "Viral factories"
is_a: GO:0033643 ! host cell part
@@ -234777,7 +235282,7 @@ creation_date: 2014-01-06T11:39:58Z
id: GO:0039723
name: suppression by virus of host TBK1 activity
namespace: biological_process
-def: "Any process in which a virus stops, prevents, or reduces the activity of the host serine/threonine kinase TBK1." [PR:000001779, UniProtKB-KW:KW-1223]
+def: "Any process in which a virus stops, prevents, or reduces the activity of the host serine/threonine kinase TBK1." [UniProtKB-KW:KW-1223]
comment: When TBK1 acts as part of a TBK1-IKBKE-DDX3 complex, consider also annotating to: suppression by virus of host TBK1-IKBKE-DDX3 complex activity ; GO:0039659.
synonym: "inhibition of host TBK1 by virus" EXACT [UniProtKB-KW:KW-1223]
is_a: GO:0039503 ! suppression by virus of host innate immune response
@@ -234789,7 +235294,7 @@ creation_date: 2014-01-06T12:04:44Z
id: GO:0039724
name: suppression by virus of host IKBKE activity
namespace: biological_process
-def: "Any process in which a virus stops, prevents, or reduces the activity of the host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [PR:000001778, UniProtKB-KW:KW-1224]
+def: "Any process in which a virus stops, prevents, or reduces the activity of the host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [UniProtKB-KW:KW-1224]
comment: When IKBKE acts as part of a TBK1-IKBKE-DDX3 complex, consider also annotating to: suppression by virus of host TBK1-IKBKE-DDX3 complex activity ; GO:0039659.
synonym: "inhibition of host IKBKE by virus" EXACT [UniProtKB-KW:KW-1224]
is_a: GO:0039503 ! suppression by virus of host innate immune response
@@ -235484,8 +235989,6 @@ synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [
synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [EC:3.4.24.72]
synonym: "fibrinolytic proteinase activity" EXACT [EC:3.4.24.72]
synonym: "fibrolase activity" EXACT []
-xref: EC:3.4.24.72
-xref: MetaCyc:3.4.24.72-RXN
is_obsolete: true
replaced_by: GO:0004222
@@ -235508,7 +236011,6 @@ comment: This term was made obsolete because it represents a regulator of a non-
synonym: "ACE inhibitor" EXACT []
synonym: "angiotensin-converting enzyme inhibitor activity" EXACT []
synonym: "peptidyl dipeptidase A inhibitor" EXACT []
-xref: Wikipedia:ACE_inhibitor
is_obsolete: true
replaced_by: GO:0060422
@@ -235663,7 +236165,6 @@ synonym: "W-molybdopterin cofactor anabolism" EXACT []
synonym: "W-molybdopterin cofactor biosynthesis" EXACT []
synonym: "W-molybdopterin cofactor formation" EXACT []
synonym: "W-molybdopterin cofactor synthesis" EXACT []
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process
is_a: GO:0090407 ! organophosphate biosynthetic process
@@ -236084,35 +236585,6 @@ is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0042107 ! cytokine metabolic process
relationship: part_of GO:0001816 ! cytokine production
-[Term]
-id: GO:0042090
-name: interleukin-12 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
-synonym: "IL-12 biosynthesis" EXACT []
-synonym: "IL-12 biosynthetic process" EXACT []
-synonym: "interleukin-12 anabolism" EXACT []
-synonym: "interleukin-12 biosynthesis" EXACT []
-synonym: "interleukin-12 formation" EXACT []
-synonym: "interleukin-12 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-relationship: part_of GO:0032615 ! interleukin-12 production
-
-[Term]
-id: GO:0042091
-name: interleukin-10 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
-synonym: "IL-10 biosynthesis" EXACT []
-synonym: "IL-10 biosynthetic process" EXACT []
-synonym: "interleukin-10 anabolism" EXACT []
-synonym: "interleukin-10 biosynthesis" EXACT []
-synonym: "interleukin-10 formation" EXACT []
-synonym: "interleukin-10 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032613 ! interleukin-10 production
-
[Term]
id: GO:0042092
name: type 2 immune response
@@ -236131,37 +236603,6 @@ synonym: "helper T cell differentiation" EXACT [CL:0000912]
synonym: "T-helper cell development" RELATED [GOC:add]
is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response
-[Term]
-id: GO:0042094
-name: interleukin-2 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
-synonym: "IL-2 biosynthesis" EXACT []
-synonym: "IL-2 biosynthetic process" EXACT []
-synonym: "interleukin-2 anabolism" EXACT []
-synonym: "interleukin-2 biosynthesis" EXACT []
-synonym: "interleukin-2 formation" EXACT []
-synonym: "interleukin-2 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032623 ! interleukin-2 production
-
-[Term]
-id: GO:0042095
-name: interferon-gamma biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:go_curators, PR:000000017]
-synonym: "IFN-gamma biosynthesis" EXACT []
-synonym: "IFN-gamma biosynthetic process" EXACT []
-synonym: "interferon type II biosynthesis" BROAD []
-synonym: "interferon type II biosynthetic process" BROAD []
-synonym: "interferon-gamma anabolism" EXACT []
-synonym: "interferon-gamma biosynthesis" EXACT []
-synonym: "interferon-gamma formation" EXACT []
-synonym: "interferon-gamma synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-relationship: part_of GO:0032609 ! interferon-gamma production
-
[Term]
id: GO:0042096
name: obsolete alpha-beta T cell receptor activity
@@ -236174,22 +236615,6 @@ consider: GO:0032394
consider: GO:0032395
consider: GO:0042605
-[Term]
-id: GO:0042097
-name: interleukin-4 biosynthetic process
-namespace: biological_process
-alt_id: GO:0042224
-def: "The chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
-synonym: "IL-4 biosynthesis" EXACT []
-synonym: "IL-4 biosynthetic process" EXACT []
-synonym: "interleukin-4 anabolism" EXACT []
-synonym: "interleukin-4 biosynthesis" EXACT []
-synonym: "interleukin-4 formation" EXACT []
-synonym: "interleukin-4 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032633 ! interleukin-4 production
-
[Term]
id: GO:0042098
name: T cell proliferation
@@ -236430,7 +236855,6 @@ def: "The chemical reactions and pathways involving alginic acid, a hydrophilic
synonym: "alginate metabolic process" EXACT []
synonym: "alginate metabolism" EXACT []
synonym: "alginic acid metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
@@ -236460,7 +236884,6 @@ synonym: "alginic acid breakdown" EXACT []
synonym: "alginic acid catabolism" EXACT []
synonym: "alginic acid degradation" EXACT []
is_a: GO:0042120 ! alginic acid metabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
@@ -236868,9 +237291,7 @@ id: GO:0042166
name: acetylcholine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
-is_a: GO:0008144 ! drug binding
is_a: GO:0042165 ! neurotransmitter binding
-is_a: GO:0042562 ! hormone binding
is_a: GO:0043169 ! cation binding
[Term]
@@ -237069,8 +237490,6 @@ synonym: "formate degradation" EXACT []
synonym: "formic acid catabolic process" EXACT []
synonym: "formic acid catabolism" EXACT []
is_a: GO:0015942 ! formate metabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
[Term]
@@ -237139,7 +237558,6 @@ synonym: "DDT catabolism" EXACT []
is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046701 ! insecticide catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -237171,7 +237589,6 @@ synonym: "vanillin catabolism" EXACT []
synonym: "vanillin degradation" EXACT []
is_a: GO:0018982 ! vanillin metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:1901502 ! ether catabolic process
@@ -237289,7 +237706,6 @@ def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a tri
synonym: "cyromazine metabolic process" EXACT []
synonym: "cyromazine metabolism" EXACT []
synonym: "N-cyclopropylmelamine metabolism" EXACT []
-is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0018965 ! s-triazine compound metabolic process
[Term]
@@ -237305,8 +237721,6 @@ synonym: "N-cyclopropylmelamine degradation" EXACT []
xref: UM-BBD_pathwayID:cpm
is_a: GO:0042201 ! N-cyclopropylmelamine metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process
-is_a: GO:0046701 ! insecticide catabolic process
-is_a: GO:0051410 ! detoxification of nitrogen compound
[Term]
id: GO:0042203
@@ -237318,7 +237732,6 @@ synonym: "toluene catabolism" EXACT []
synonym: "toluene degradation" EXACT []
is_a: GO:0018970 ! toluene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072491 ! toluene-containing compound catabolic process
[Term]
@@ -237441,7 +237854,6 @@ def: "The chemical reactions and pathways involving cresol, a mixture of the aro
synonym: "cresol metabolism" EXACT []
synonym: "hydroxytoluene metabolic process" EXACT []
synonym: "hydroxytoluene metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0072490 ! toluene-containing compound metabolic process
@@ -237491,7 +237903,6 @@ xref: UM-BBD_pathwayID:phe
is_a: GO:0018955 ! phenanthrene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
[Term]
@@ -237541,10 +237952,8 @@ id: GO:0042220
name: response to cocaine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:ef, GOC:jl]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid
-is_a: GO:0072347 ! response to anesthetic
is_a: GO:1901700 ! response to oxygen-containing compound
[Term]
@@ -237564,289 +237973,6 @@ synonym: "response to chemical stimulus" EXACT [GOC:dos]
synonym: "response to chemical substance" EXACT []
is_a: GO:0050896 ! response to stimulus
-[Term]
-id: GO:0042222
-name: interleukin-1 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen." [GOC:jl, ISBN:0198506732]
-synonym: "IL-1 biosynthesis" EXACT []
-synonym: "IL-1 biosynthetic process" EXACT []
-synonym: "interleukin-1 anabolism" EXACT []
-synonym: "interleukin-1 biosynthesis" EXACT []
-synonym: "interleukin-1 formation" EXACT []
-synonym: "interleukin-1 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032612 ! interleukin-1 production
-
-[Term]
-id: GO:0042223
-name: interleukin-3 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
-synonym: "IL-3 biosynthesis" EXACT []
-synonym: "IL-3 biosynthetic process" EXACT []
-synonym: "interleukin-3 anabolism" EXACT []
-synonym: "interleukin-3 biosynthesis" EXACT []
-synonym: "interleukin-3 formation" EXACT []
-synonym: "interleukin-3 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032632 ! interleukin-3 production
-
-[Term]
-id: GO:0042225
-name: interleukin-5 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
-synonym: "IL-5 biosynthesis" EXACT []
-synonym: "IL-5 biosynthetic process" EXACT []
-synonym: "interleukin-5 anabolism" EXACT []
-synonym: "interleukin-5 biosynthesis" EXACT []
-synonym: "interleukin-5 formation" EXACT []
-synonym: "interleukin-5 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032634 ! interleukin-5 production
-
-[Term]
-id: GO:0042226
-name: interleukin-6 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
-synonym: "IL-6 biosynthesis" EXACT []
-synonym: "IL-6 biosynthetic process" EXACT []
-synonym: "interleukin-6 anabolism" EXACT []
-synonym: "interleukin-6 biosynthesis" EXACT []
-synonym: "interleukin-6 formation" EXACT []
-synonym: "interleukin-6 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032635 ! interleukin-6 production
-
-[Term]
-id: GO:0042227
-name: interleukin-7 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
-synonym: "IL-7 biosynthesis" EXACT []
-synonym: "IL-7 biosynthetic process" EXACT []
-synonym: "interleukin-7 anabolism" EXACT []
-synonym: "interleukin-7 biosynthesis" EXACT []
-synonym: "interleukin-7 formation" EXACT []
-synonym: "interleukin-7 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032636 ! interleukin-7 production
-
-[Term]
-id: GO:0042228
-name: interleukin-8 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
-synonym: "IL-8 biosynthesis" EXACT []
-synonym: "IL-8 biosynthetic process" EXACT []
-synonym: "interleukin-8 anabolism" EXACT []
-synonym: "interleukin-8 biosynthesis" EXACT []
-synonym: "interleukin-8 formation" EXACT []
-synonym: "interleukin-8 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032637 ! interleukin-8 production
-
-[Term]
-id: GO:0042229
-name: interleukin-9 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
-synonym: "IL-9 biosynthesis" EXACT []
-synonym: "IL-9 biosynthetic process" EXACT []
-synonym: "interleukin-9 anabolism" EXACT []
-synonym: "interleukin-9 biosynthesis" EXACT []
-synonym: "interleukin-9 formation" EXACT []
-synonym: "interleukin-9 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032638 ! interleukin-9 production
-
-[Term]
-id: GO:0042230
-name: interleukin-11 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
-synonym: "IL-11 biosynthesis" EXACT []
-synonym: "IL-11 biosynthetic process" EXACT []
-synonym: "interleukin-11 anabolism" EXACT []
-synonym: "interleukin-11 biosynthesis" EXACT []
-synonym: "interleukin-11 formation" EXACT []
-synonym: "interleukin-11 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032614 ! interleukin-11 production
-
-[Term]
-id: GO:0042231
-name: interleukin-13 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
-synonym: "IL-13 biosynthesis" EXACT []
-synonym: "IL-13 biosynthetic process" EXACT []
-synonym: "interleukin-13 anabolism" EXACT []
-synonym: "interleukin-13 biosynthesis" EXACT []
-synonym: "interleukin-13 formation" EXACT []
-synonym: "interleukin-13 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032616 ! interleukin-13 production
-
-[Term]
-id: GO:0042232
-name: interleukin-14 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
-synonym: "IL-14 biosynthesis" EXACT []
-synonym: "IL-14 biosynthetic process" EXACT []
-synonym: "interleukin-14 anabolism" EXACT []
-synonym: "interleukin-14 biosynthesis" EXACT []
-synonym: "interleukin-14 formation" EXACT []
-synonym: "interleukin-14 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-relationship: part_of GO:0032617 ! interleukin-14 production
-
-[Term]
-id: GO:0042233
-name: interleukin-15 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
-synonym: "IL-15 biosynthesis" EXACT []
-synonym: "IL-15 biosynthetic process" EXACT []
-synonym: "interleukin-15 anabolism" EXACT []
-synonym: "interleukin-15 biosynthesis" EXACT []
-synonym: "interleukin-15 formation" EXACT []
-synonym: "interleukin-15 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032618 ! interleukin-15 production
-
-[Term]
-id: GO:0042234
-name: interleukin-16 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
-synonym: "IL-16 biosynthesis" EXACT []
-synonym: "IL-16 biosynthetic process" EXACT []
-synonym: "interleukin-16 anabolism" EXACT []
-synonym: "interleukin-16 biosynthesis" EXACT []
-synonym: "interleukin-16 formation" EXACT []
-synonym: "interleukin-16 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032619 ! interleukin-16 production
-
-[Term]
-id: GO:0042235
-name: interleukin-17 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]
-synonym: "IL-17 biosynthesis" EXACT []
-synonym: "IL-17 biosynthetic process" EXACT []
-synonym: "interleukin-17 anabolism" EXACT []
-synonym: "interleukin-17 biosynthesis" EXACT []
-synonym: "interleukin-17 formation" EXACT []
-synonym: "interleukin-17 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032620 ! interleukin-17 production
-
-[Term]
-id: GO:0042236
-name: interleukin-19 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
-synonym: "IL-19 biosynthesis" EXACT []
-synonym: "IL-19 biosynthetic process" EXACT []
-synonym: "interleukin-19 anabolism" EXACT []
-synonym: "interleukin-19 biosynthesis" EXACT []
-synonym: "interleukin-19 formation" EXACT []
-synonym: "interleukin-19 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032622 ! interleukin-19 production
-
-[Term]
-id: GO:0042237
-name: interleukin-20 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
-synonym: "IL-20 biosynthesis" EXACT []
-synonym: "IL-20 biosynthetic process" EXACT []
-synonym: "interleukin-20 anabolism" EXACT []
-synonym: "interleukin-20 biosynthesis" EXACT []
-synonym: "interleukin-20 formation" EXACT []
-synonym: "interleukin-20 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032624 ! interleukin-20 production
-
-[Term]
-id: GO:0042238
-name: interleukin-21 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
-synonym: "IL-21 biosynthesis" EXACT []
-synonym: "IL-21 biosynthetic process" EXACT []
-synonym: "interleukin-21 anabolism" EXACT []
-synonym: "interleukin-21 biosynthesis" EXACT []
-synonym: "interleukin-21 formation" EXACT []
-synonym: "interleukin-21 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032625 ! interleukin-21 production
-
-[Term]
-id: GO:0042239
-name: interleukin-22 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
-synonym: "IL-22 biosynthesis" EXACT []
-synonym: "IL-22 biosynthetic process" EXACT []
-synonym: "interleukin-22 anabolism" EXACT []
-synonym: "interleukin-22 biosynthesis" EXACT []
-synonym: "interleukin-22 formation" EXACT []
-synonym: "interleukin-22 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032626 ! interleukin-22 production
-
-[Term]
-id: GO:0042240
-name: interleukin-23 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
-synonym: "IL-23 biosynthesis" EXACT []
-synonym: "IL-23 biosynthetic process" EXACT []
-synonym: "interleukin-23 anabolism" EXACT []
-synonym: "interleukin-23 biosynthesis" EXACT []
-synonym: "interleukin-23 formation" EXACT []
-synonym: "interleukin-23 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-relationship: part_of GO:0032627 ! interleukin-23 production
-
-[Term]
-id: GO:0042241
-name: interleukin-18 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
-synonym: "IL-18 biosynthesis" EXACT []
-synonym: "IL-18 biosynthetic process" EXACT []
-synonym: "interleukin-18 anabolism" EXACT []
-synonym: "interleukin-18 biosynthesis" EXACT []
-synonym: "interleukin-18 formation" EXACT []
-synonym: "interleukin-18 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032621 ! interleukin-18 production
-
[Term]
id: GO:0042242
name: cobyrinic acid a,c-diamide synthase activity
@@ -237899,7 +238025,6 @@ def: "The regrowth of lost or destroyed tissues." [GOC:curators]
is_a: GO:0009888 ! tissue development
is_a: GO:0031099 ! regeneration
is_a: GO:0048589 ! developmental growth
-relationship: part_of GO:0042060 ! wound healing
[Term]
id: GO:0042247
@@ -238211,6 +238336,7 @@ synonym: "multiheme nitrite reductase activity" EXACT []
synonym: "nitrite reductase (cytochrome; ammonia-forming)" EXACT [EC:1.7.2.2]
xref: EC:1.7.2.2
xref: MetaCyc:1.7.2.2-RXN
+xref: RHEA:13089
xref: Wikipedia:Cytochrome_c_nitrite_reductase
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
is_a: GO:0098809 ! nitrite reductase activity
@@ -238234,6 +238360,7 @@ def: "Catalysis of the addition of the first glucose residue to the lipid-linked
synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.267
xref: MetaCyc:RXN-5470
+xref: RHEA:30635
is_a: GO:0046527 ! glucosyltransferase activity
relationship: part_of GO:0006490 ! oligosaccharide-lipid intermediate biosynthetic process
@@ -238264,6 +238391,7 @@ def: "Catalysis of the addition of the second glucose residue to the lipid-linke
synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.265
xref: MetaCyc:RXN-5471
+xref: RHEA:31307
is_a: GO:0046527 ! glucosyltransferase activity
[Term]
@@ -238397,6 +238525,7 @@ def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction i
synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99
xref: MetaCyc:RXN-111
+xref: RHEA:31383
is_a: GO:0031559 ! oxidosqualene cyclase activity
[Term]
@@ -238591,8 +238720,6 @@ synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "prolinase activity" NARROW [EC:3.4.13.18]
synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18]
-xref: EC:3.4.13.18
-xref: MetaCyc:3.4.13.18-RXN
is_obsolete: true
replaced_by: GO:0016805
@@ -239053,7 +239180,6 @@ synonym: "thiamine pyrophosphate metabolism" EXACT []
synonym: "TPP metabolic process" EXACT []
synonym: "TPP metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
@@ -239075,7 +239201,6 @@ synonym: "thiamine pyrophosphate catabolic process" EXACT []
synonym: "thiamine pyrophosphate catabolism" EXACT []
synonym: "TPP catabolic process" EXACT []
synonym: "TPP catabolism" EXACT []
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042357 ! thiamine diphosphate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
@@ -239189,8 +239314,6 @@ synonym: "vitamin B12 catabolism" EXACT []
is_a: GO:0009235 ! cobalamin metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
-is_a: GO:0042737 ! drug catabolic process
-is_a: GO:0051187 ! cofactor catabolic process
[Term]
id: GO:0042367
@@ -239205,9 +239328,7 @@ synonym: "vitamin B7 catabolism" EXACT []
synonym: "vitamin H catabolic process" EXACT []
synonym: "vitamin H catabolism" EXACT []
is_a: GO:0006768 ! biotin metabolic process
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
@@ -239295,7 +239416,6 @@ synonym: "phytylmenaquinone biosynthetic process" EXACT []
synonym: "vitamin K1 biosynthesis" EXACT []
synonym: "vitamin K1 biosynthetic process" EXACT []
xref: MetaCyc:PWY-5027
-is_a: GO:0009110 ! vitamin biosynthetic process
is_a: GO:0042374 ! phylloquinone metabolic process
is_a: GO:1901663 ! quinone biosynthetic process
@@ -239323,7 +239443,6 @@ synonym: "phytylmenaquinone metabolic process" EXACT []
synonym: "phytylmenaquinone metabolism" EXACT []
synonym: "vitamin K1 metabolic process" EXACT []
synonym: "vitamin K1 metabolism" EXACT []
-is_a: GO:0006766 ! vitamin metabolic process
is_a: GO:1901661 ! quinone metabolic process
[Term]
@@ -239342,7 +239461,6 @@ synonym: "phytylmenaquinone catabolic process" EXACT []
synonym: "phytylmenaquinone catabolism" EXACT []
synonym: "vitamin K1 catabolic process" EXACT []
synonym: "vitamin K1 catabolism" EXACT []
-is_a: GO:0009111 ! vitamin catabolic process
is_a: GO:0042374 ! phylloquinone metabolic process
is_a: GO:1901662 ! quinone catabolic process
@@ -239462,7 +239580,7 @@ is_a: GO:0065008 ! regulation of biological quality
id: GO:0042392
name: sphingosine-1-phosphate phosphatase activity
namespace: molecular_function
-def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:11331102]
+def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:8663293]
synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT []
synonym: "SPP phosphatase activity" EXACT []
synonym: "SPPase activity" EXACT []
@@ -239470,6 +239588,7 @@ xref: MetaCyc:RXN3DJ-25
xref: Reactome:R-HSA-428690 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]"
xref: Reactome:R-HSA-428696 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]"
xref: Reactome:R-HSA-428701 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]"
+xref: RHEA:27518
is_a: GO:0042577 ! lipid phosphatase activity
[Term]
@@ -239755,7 +239874,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]
synonym: "dopamine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process
-is_a: GO:0017144 ! drug metabolic process
[Term]
id: GO:0042418
@@ -239794,7 +239912,6 @@ synonym: "dopamine catabolism" EXACT []
synonym: "dopamine degradation" EXACT []
is_a: GO:0042417 ! dopamine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0042421
@@ -239865,7 +239982,6 @@ synonym: "choline formation" EXACT []
synonym: "choline synthesis" EXACT []
xref: MetaCyc:PWY-4762
is_a: GO:0019695 ! choline metabolic process
-is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
[Term]
@@ -239877,7 +239993,6 @@ synonym: "choline breakdown" EXACT []
synonym: "choline catabolism" EXACT []
synonym: "choline degradation" EXACT []
is_a: GO:0019695 ! choline metabolic process
-is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
[Term]
@@ -239890,7 +240005,6 @@ synonym: "serotonin biosynthesis" EXACT []
synonym: "serotonin formation" EXACT []
synonym: "serotonin synthesis" EXACT []
xref: Wikipedia:Serotonin
-is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
@@ -239903,7 +240017,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
-is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process
@@ -239917,7 +240030,6 @@ synonym: "serotonin breakdown" EXACT []
synonym: "serotonin catabolism" EXACT []
synonym: "serotonin degradation" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
-is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:1901161 ! primary amino compound catabolic process
@@ -240078,7 +240190,6 @@ synonym: "melatonin degradation" EXACT []
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042436 ! indole-containing compound catabolic process
is_a: GO:0042447 ! hormone catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0042443
@@ -240143,7 +240254,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/]
synonym: "progesterone metabolism" EXACT []
is_a: GO:0008207 ! C21-steroid hormone metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
[Term]
@@ -240224,7 +240334,6 @@ synonym: "ethylene breakdown" EXACT []
synonym: "ethylene catabolism" EXACT []
synonym: "ethylene degradation" EXACT []
is_a: GO:0009692 ! ethylene metabolic process
-is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0043451 ! alkene catabolic process
[Term]
@@ -240651,7 +240760,6 @@ def: "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide,
comment: This term was made obsolete because it represents a gene product.
synonym: "signal peptide peptidase activity" EXACT []
synonym: "SPP" EXACT []
-xref: EC:3.4.23
is_obsolete: true
replaced_by: GO:0042500
@@ -240997,10 +241105,7 @@ name: response to hydrogen peroxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]
is_a: GO:0000302 ! response to reactive oxygen species
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0010035 ! response to inorganic substance
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
[Term]
id: GO:0042543
@@ -241150,6 +241255,7 @@ id: GO:0042559
name: pteridine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]
+subset: goslim_pombe
synonym: "pteridine and derivative biosynthesis" EXACT []
synonym: "pteridine and derivative biosynthetic process" EXACT []
synonym: "pteridine-containing compound anabolism" EXACT []
@@ -241315,8 +241421,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21]
comment: This term was made obsolete because it represents a gene product.
synonym: "aspartyl aminopeptidase activity" EXACT []
-xref: EC:3.4.11.21
-xref: MetaCyc:3.4.11.21-RXN
is_obsolete: true
replaced_by: GO:0004177
@@ -241402,6 +241506,7 @@ synonym: "PDF activity" EXACT [EC:3.5.1.88]
synonym: "polypeptide deformylase activity" EXACT [EC:3.5.1.88]
xref: EC:3.5.1.88
xref: MetaCyc:3.5.1.88-RXN
+xref: RHEA:24420
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -241673,7 +241778,6 @@ synonym: "paclitaxel metabolism" EXACT []
synonym: "taxol metabolic process" NARROW []
synonym: "taxol metabolism" NARROW []
is_a: GO:0016101 ! diterpenoid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
[Term]
@@ -241694,7 +241798,7 @@ is_a: GO:0042616 ! paclitaxel metabolic process
id: GO:0042618
name: poly-hydroxybutyrate metabolic process
namespace: biological_process
-def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl\,PMID\:18640095]
+def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, PMID:18640095]
synonym: "PHB metabolic process" EXACT []
synonym: "PHB metabolism" EXACT []
synonym: "poly-hydroxybutyrate metabolism" EXACT []
@@ -241780,11 +241884,6 @@ synonym: "hydrolase activity, acting on acid anhydrides, catalyzing transmembran
synonym: "P-P-bond-hydrolysis-driven transmembrane transporter activity" BROAD []
synonym: "P-P-bond-hydrolysis-driven transporter" BROAD []
xref: EC:7.2.2
-xref: Reactome:R-HSA-266070 "LTC4 is exported from the cytosol by ABCC1"
-xref: Reactome:R-HSA-5223313 "ABCD4 may transport Cbl from lysosomal lumen to cytosol"
-xref: Reactome:R-HSA-5362459 "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol"
-xref: Reactome:R-HSA-5387389 "Hh processing variants are translocated to the cytosol in a VCP-dependent manner"
-xref: Reactome:R-HSA-5683325 "Defective ABCD4 does not transport Cbl from lysosomal lumen to cytosol"
is_a: GO:0015399 ! primary active transmembrane transporter activity
relationship: has_part GO:0016887 ! ATPase activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14642 xsd:anyURI
@@ -241960,13 +242059,12 @@ relationship: part_of GO:0042641 ! actomyosin
[Term]
id: GO:0042643
-name: actomyosin, actin portion
+name: obsolete actomyosin, actin portion
namespace: cellular_component
-def: "The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
-is_a: GO:0005884 ! actin filament
-intersection_of: GO:0005884 ! actin filament
-intersection_of: part_of GO:0042641 ! actomyosin
-relationship: part_of GO:0042641 ! actomyosin
+def: "OBSOLETE. The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
+comment: This term was obsoleted because it corresponds to a gene product, actin.
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19570 xsd:anyURI
+is_obsolete: true
[Term]
id: GO:0042644
@@ -242524,7 +242622,6 @@ id: GO:0042701
name: progesterone secretion
namespace: biological_process
def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172]
-is_a: GO:0015893 ! drug transport
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0035929 ! steroid hormone secretion
@@ -242733,7 +242830,6 @@ synonym: "vitamin B1 and derivative metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0072527 ! pyrimidine-containing compound metabolic process
[Term]
@@ -242776,7 +242872,6 @@ synonym: "vitamin B1 and derivative catabolism" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042723 ! thiamine-containing compound metabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0072529 ! pyrimidine-containing compound catabolic process
@@ -242987,8 +243082,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, PMID:21734470]
synonym: "H2O2 metabolic process" EXACT [GOC:mah]
synonym: "hydrogen peroxide metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:0072593 ! reactive oxygen species metabolic process
[Term]
@@ -243005,10 +243098,8 @@ synonym: "hydrogen peroxide catabolism" EXACT []
synonym: "hydrogen peroxide degradation" EXACT []
synonym: "hydrogen peroxide removal" RELATED []
synonym: "hydrogen peroxide scavenging" RELATED [GOC:vw]
-is_a: GO:0017001 ! antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0042743 ! hydrogen peroxide metabolic process
-is_a: GO:0051187 ! cofactor catabolic process
+is_a: GO:0044248 ! cellular catabolic process
[Term]
id: GO:0042745
@@ -243219,8 +243310,8 @@ namespace: cellular_component
def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]
comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity.
synonym: "GPIT complex" EXACT []
+is_a: GO:0008303 ! caspase complex
is_a: GO:0098796 ! membrane protein complex
-is_a: GO:1902494 ! catalytic complex
relationship: part_of GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane
@@ -243756,7 +243847,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
synonym: "vitamin B6 metabolism" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
[Term]
@@ -243768,7 +243858,6 @@ synonym: "pyridoxal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
[Term]
@@ -243804,7 +243893,6 @@ synonym: "vitamin B6 breakdown" EXACT []
synonym: "vitamin B6 catabolism" EXACT []
synonym: "vitamin B6 degradation" EXACT []
is_a: GO:0042365 ! water-soluble vitamin catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
@@ -243821,20 +243909,18 @@ is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042817 ! pyridoxal metabolic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
[Term]
id: GO:0042822
name: pyridoxal phosphate metabolic process
namespace: biological_process
-def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/]
+def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]
synonym: "active vitamin B6 metabolic process" EXACT []
synonym: "active vitamin B6 metabolism" EXACT []
synonym: "pyridoxal phosphate metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
@@ -243844,7 +243930,7 @@ is_a: GO:1901615 ! organic hydroxy compound metabolic process
id: GO:0042823
name: pyridoxal phosphate biosynthetic process
namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/]
+def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]
synonym: "active vitamin B6 biosynthesis" EXACT []
synonym: "active vitamin B6 biosynthetic process" EXACT []
synonym: "pyridoxal phosphate anabolism" EXACT []
@@ -243852,7 +243938,6 @@ synonym: "pyridoxal phosphate biosynthesis" EXACT []
synonym: "pyridoxal phosphate formation" EXACT []
synonym: "pyridoxal phosphate synthesis" EXACT []
xref: MetaCyc:PWY0-845
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process
is_a: GO:0042822 ! pyridoxal phosphate metabolic process
@@ -243893,7 +243978,7 @@ is_a: GO:0019899 ! enzyme binding
id: GO:0042827
name: platelet dense granule
namespace: cellular_component
-def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682, PMID:11487378]
+def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, PMID:10403682, PMID:11487378]
synonym: "bull's eye body" EXACT []
synonym: "platelet dense body" EXACT []
is_a: GO:0030141 ! secretory granule
@@ -243934,7 +244019,6 @@ def: "The chemical reactions and pathways involving D-glucarate, the D-enantiome
synonym: "D-glucarate metabolism" EXACT []
synonym: "saccharate metabolic process" EXACT []
synonym: "saccharate metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0019392 ! glucarate metabolic process
[Term]
@@ -243962,7 +244046,6 @@ synonym: "D-glucarate degradation" EXACT []
synonym: "saccharate catabolic process" EXACT []
synonym: "saccharate catabolism" EXACT []
is_a: GO:0019394 ! glucarate catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0042836 ! D-glucarate metabolic process
[Term]
@@ -244372,7 +244455,6 @@ name: D-glucarate transmembrane transport
namespace: biological_process
def: "The process in which D-glucarate, the D-enantiomer of glucarate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732]
synonym: "D-glucarate transport" RELATED []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0042869 ! aldarate transmembrane transport
[Term]
@@ -244535,9 +244617,9 @@ name: chloramphenicol transmembrane transport
namespace: biological_process
def: "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, across a lipid bilayer, from one side of a membrane to the other." [PMID:29150447]
synonym: "chloramphenicol transport" BROAD []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015791 ! polyol transport
is_a: GO:0042886 ! amide transport
+is_a: GO:0055085 ! transmembrane transport
[Term]
id: GO:0042893
@@ -244656,7 +244738,6 @@ name: 9-cis-retinoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029]
synonym: "9-cis-retinoic acid metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0042573 ! retinoic acid metabolic process
[Term]
@@ -244782,7 +244863,6 @@ name: benzoate transport
namespace: biological_process
def: "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0721662544]
is_a: GO:0015718 ! monocarboxylic acid transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0042908 ! xenobiotic transport
[Term]
@@ -244880,7 +244960,7 @@ synonym: "enterochelin transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0015891 ! siderophore transport
-is_a: GO:0051181 ! cofactor transport
+is_a: GO:0042969 ! lactone transport
[Term]
id: GO:0042931
@@ -244891,7 +244971,7 @@ synonym: "enterobactin transporter activity" RELATED []
synonym: "enterochelin transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015343 ! siderophore transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
+is_a: GO:0042971 ! lactone transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:0042930 ! enterobactin transport
@@ -244900,11 +244980,11 @@ id: GO:0042932
name: chrysobactin transport
namespace: biological_process
def: "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:8837459]
+is_a: GO:0015695 ! organic cation transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0015891 ! siderophore transport
is_a: GO:0042938 ! dipeptide transport
-is_a: GO:0051181 ! cofactor transport
[Term]
id: GO:0042933
@@ -244913,9 +244993,9 @@ namespace: molecular_function
def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other." [GOC:jl, PMID:8837459]
synonym: "chrysobactin transporter activity" RELATED []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
+is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015343 ! siderophore transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
is_a: GO:0071916 ! dipeptide transmembrane transporter activity
relationship: part_of GO:0042932 ! chrysobactin transport
@@ -244928,7 +245008,6 @@ synonym: "achromobactin transporter activity" RELATED []
is_a: GO:0015343 ! siderophore transmembrane transporter activity
is_a: GO:0042887 ! amide transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
relationship: part_of GO:0042935 ! achromobactin transport
@@ -244941,7 +245020,6 @@ is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0015891 ! siderophore transport
is_a: GO:0042886 ! amide transport
is_a: GO:0046942 ! carboxylic acid transport
-is_a: GO:0051181 ! cofactor transport
[Term]
id: GO:0042937
@@ -244986,7 +245064,6 @@ id: GO:0042942
name: D-serine transport
namespace: biological_process
def: "The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
-is_a: GO:0015893 ! drug transport
is_a: GO:0032329 ! serine transport
is_a: GO:0042940 ! D-amino acid transport
@@ -245042,7 +245119,6 @@ namespace: biological_process
def: "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0015759 ! beta-glucoside transport
is_a: GO:0015850 ! organic hydroxy compound transport
-is_a: GO:0015893 ! drug transport
[Term]
id: GO:0042949
@@ -245090,7 +245166,6 @@ name: obsolete lipoprotein transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732]
comment: The reason for obsoletion is this term has been incorrectly used.
-xref: Reactome:R-HSA-350168 "LRP2 transports CUBN:GC:25(OH)D from extracellular region to cytosol"
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17004 xsd:anyURI
is_obsolete: true
@@ -245098,21 +245173,21 @@ is_obsolete: true
id: GO:0042955
name: dextrin transport
namespace: biological_process
-def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/]
+def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0015774 ! polysaccharide transport
[Term]
id: GO:0042956
name: maltodextrin transport
namespace: biological_process
-def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/]
+def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
is_a: GO:0015774 ! polysaccharide transport
[Term]
id: GO:0042957
name: dextrin transmembrane transporter activity
namespace: molecular_function
-def: "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other." [GOC:jl, GOC:vk, http://www.mercksource.com/]
+def: "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other." [GOC:jl, GOC:vk]
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity
relationship: part_of GO:0042955 ! dextrin transport
@@ -245120,7 +245195,7 @@ relationship: part_of GO:0042955 ! dextrin transport
id: GO:0042958
name: maltodextrin transmembrane transporter activity
namespace: molecular_function
-def: "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other." [GOC:jl, http://www.mercksource.com/, PMID:15034926]
+def: "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other." [GOC:jl, PMID:15034926]
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity
relationship: part_of GO:0042956 ! maltodextrin transport
@@ -245755,6 +245830,7 @@ alt_id: GO:0001747
alt_id: GO:0031075
def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001654 ! eye development
+property_value: RO:0002161 NCBITaxon:6656
[Term]
id: GO:0043011
@@ -246835,7 +246911,7 @@ name: neurotrophin binding
namespace: molecular_function
alt_id: GO:0048404
alt_id: GO:0048405
-def: "Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl, http://www.mercksource.com/, PR:000021998]
+def: "Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl]
comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
synonym: "neurotrophic factor binding" EXACT [GOC:aruk, GOC:bc]
synonym: "neurotrophin 3 binding" NARROW []
@@ -246995,7 +247071,6 @@ synonym: "oxidized nicotinamide adenine dinucleotide transport" EXACT []
synonym: "reduced NAD transport" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
-is_a: GO:0051182 ! coenzyme transport
[Term]
id: GO:0043133
@@ -247052,6 +247127,14 @@ def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwindi
synonym: "3' to 5' DNA helicase activity" EXACT []
synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT []
synonym: "ATP-dependent 3'-5' DNA helicase activity" EXACT []
+xref: Reactome:R-HSA-167097 "HIV Promoter Opening: First Transition"
+xref: Reactome:R-HSA-174438 "Formation of the Flap Intermediate on the C-strand"
+xref: Reactome:R-HSA-75949 "RNA Polymerase II Promoter Opening: First Transition"
+xref: Reactome:R-HSA-9613490 "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition"
+xref: Reactome:R-HSA-9613494 "Unwinding of DNA for the Nascent Transcript: Second Transition"
+xref: Reactome:R-HSA-9613497 "Unwinding DNA for the nascent transcript"
+xref: Reactome:R-HSA-9613498 "Unwinding of DNA for the nascent HIV-1 transcript"
+xref: Reactome:R-HSA-9684118 "ERCC3-facilitated RNA Pol II backtracking in TC-NER"
is_a: GO:0003678 ! DNA helicase activity
[Term]
@@ -247065,6 +247148,7 @@ synonym: "5' to 3' DNA helicase activity" EXACT []
synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT []
synonym: "ATP-dependent 5'-3' DNA helicase activity" EXACT []
synonym: "DNA helicase IV activity" NARROW []
+xref: Reactome:R-HSA-6782131 "ERCC2-facilitated RNA Pol II backtracking in TC-NER"
is_a: GO:0003678 ! DNA helicase activity
[Term]
@@ -247489,15 +247573,6 @@ synonym: "polar granule" EXACT []
is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule
relationship: part_of GO:0060293 ! germ plasm
-[Term]
-id: GO:0043187
-name: cell septum surface
-namespace: cellular_component
-def: "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators]
-synonym: "septum surface" BROAD []
-is_a: GO:0110165 ! cellular anatomical entity
-relationship: part_of GO:0030428 ! cell septum
-
[Term]
id: GO:0043188
name: cell septum edging
@@ -247712,6 +247787,7 @@ name: ATPase-coupled bacteriocin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate." [GOC:mlg]
synonym: "bacteriocin ABC transporter" NARROW []
+is_a: GO:0008559 ! ATPase-coupled xenobiotic transmembrane transporter activity
is_a: GO:0015440 ! ATPase-coupled peptide transmembrane transporter activity
is_a: GO:0022885 ! bacteriocin transmembrane transporter activity
@@ -247719,7 +247795,7 @@ is_a: GO:0022885 ! bacteriocin transmembrane transporter activity
id: GO:0043215
name: daunorubicin transport
namespace: biological_process
-def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg, http://www.mercksource.com/]
+def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015893 ! drug transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -248165,6 +248241,7 @@ synonym: "ADPase activity" EXACT [EC:3.6.1.5]
synonym: "ATP diphosphohydrolase activity" EXACT [EC:3.6.1.5]
synonym: "ATP-diphosphatase activity" EXACT [EC:3.6.1.5]
xref: MetaCyc:APYRASE-RXN
+xref: RHEA:20988
is_a: GO:0017110 ! nucleoside-diphosphatase activity
[Term]
@@ -248358,7 +248435,6 @@ synonym: "pteroylpolygammaglutamyl hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolyglutamic acid hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21]
-xref: EC:3.4.17.21
is_obsolete: true
replaced_by: GO:0004181
@@ -248388,9 +248464,7 @@ id: GO:0043278
name: response to morphine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:ef, GOC:jl]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0014072 ! response to isoquinoline alkaloid
-is_a: GO:0072347 ! response to anesthetic
[Term]
id: GO:0043279
@@ -248544,7 +248618,6 @@ name: glutathione binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732]
is_a: GO:0043168 ! anion binding
-is_a: GO:0048037 ! cofactor binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:1900750 ! oligopeptide binding
is_a: GO:1901681 ! sulfur compound binding
@@ -248641,10 +248714,9 @@ synonym: "mast cell granule exocytosis" EXACT []
is_a: GO:0002279 ! mast cell activation involved in immune response
is_a: GO:0032418 ! lysosome localization
is_a: GO:0043299 ! leukocyte degranulation
-is_a: GO:0046907 ! intracellular transport
is_a: GO:0051656 ! establishment of organelle localization
-relationship: occurs_in GO:0042629 ! mast cell granule
relationship: part_of GO:0002448 ! mast cell mediated immunity
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/15943 xsd:anyURI
[Term]
id: GO:0043304
@@ -248653,7 +248725,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149]
synonym: "regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
-is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0033006 ! regulation of mast cell activation involved in immune response
is_a: GO:0043300 ! regulation of leukocyte degranulation
intersection_of: GO:0008150 ! biological_process
@@ -248671,7 +248742,6 @@ synonym: "downregulation of mast cell degranulation" EXACT []
synonym: "inhibition of mast cell degranulation" NARROW []
synonym: "negative regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
-is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0033007 ! negative regulation of mast cell activation involved in immune response
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
@@ -248691,7 +248761,6 @@ synonym: "up regulation of mast cell degranulation" EXACT []
synonym: "up-regulation of mast cell degranulation" EXACT []
synonym: "upregulation of mast cell degranulation" EXACT []
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
-is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0033008 ! positive regulation of mast cell activation involved in immune response
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
@@ -249141,6 +249210,7 @@ synonym: "cardiolipin synthase" BROAD []
synonym: "cardiolipin synthetase" BROAD []
xref: MetaCyc:RXN-8141
xref: Reactome:R-HSA-1483063 "PG and CDP-DAG are converted to CL by CRLS1"
+xref: RHEA:32931
is_a: GO:0030572 ! phosphatidyltransferase activity
[Term]
@@ -249218,6 +249288,7 @@ synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizin
synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4]
xref: EC:1.97.1.4
xref: MetaCyc:TDCEACT-RXN
+xref: RHEA:19225
is_a: GO:0043364 ! glycyl-radical enzyme activating activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14190 xsd:anyURI
@@ -249635,7 +249706,6 @@ def: "The regulated release of corticotropin-releasing hormone (CRH), a polypept
synonym: "corticotropin-releasing factor secretion" EXACT []
synonym: "CRF secretion" EXACT []
synonym: "CRH secretion" EXACT []
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0030072 ! peptide hormone secretion
[Term]
@@ -249646,7 +249716,6 @@ def: "Any process that modulates the frequency, rate or extent of corticotropin-
synonym: "regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "regulation of CRF secretion" EXACT []
synonym: "regulation of CRH secretion" EXACT []
-is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0043396 ! corticotropin-releasing hormone secretion
@@ -249675,7 +249744,6 @@ namespace: biological_process
def: "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [PMID:11027914]
synonym: "hydrocortisone secretion" EXACT [CHEBI:17650]
is_a: GO:0015850 ! organic hydroxy compound transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0035933 ! glucocorticoid secretion
[Term]
@@ -249887,7 +249955,6 @@ synonym: "up-regulation of skeletal muscle regeneration" EXACT []
synonym: "upregulation of skeletal muscle regeneration" EXACT []
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0048639 ! positive regulation of developmental growth
-is_a: GO:0090303 ! positive regulation of wound healing
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration
relationship: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration
@@ -249899,7 +249966,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048638 ! regulation of developmental growth
-is_a: GO:0061041 ! regulation of wound healing
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0043403 ! skeletal muscle tissue regeneration
@@ -249916,7 +249982,6 @@ synonym: "downregulation of skeletal muscle regeneration" EXACT []
synonym: "inhibition of skeletal muscle regeneration" NARROW []
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0048640 ! negative regulation of developmental growth
-is_a: GO:0061045 ! negative regulation of wound healing
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration
relationship: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration
@@ -249961,7 +250026,6 @@ synonym: "anthranilic acid metabolism" NARROW []
synonym: "ortho-aminobenzoic acid metabolic process" NARROW []
synonym: "ortho-aminobenzoic acid metabolism" NARROW []
xref: UM-BBD_pathwayID:abz2
-is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -249986,7 +250050,6 @@ synonym: "ortho-aminobenzoic acid catabolism" NARROW []
xref: MetaCyc:2AMINOBENZDEG-PWY
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
-is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0043420 ! anthranilate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
@@ -250058,6 +250121,7 @@ def: "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-ad
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
xref: MetaCyc:RXN-9227
+xref: RHEA:44756
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
[Term]
@@ -250077,6 +250141,7 @@ def: "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-ade
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
xref: Reactome:R-HSA-2162188 "MDMQ10H2 is methylated to DMQ10H2 by COQ5"
+xref: RHEA:44764
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
[Term]
@@ -251016,7 +251081,7 @@ relationship: part_of GO:0005615 ! extracellular space
id: GO:0043515
name: kinetochore binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl, http://www.mercksource.com/]
+def: "Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl]
is_a: GO:0005488 ! binding
[Term]
@@ -251361,7 +251426,6 @@ def: "The chemical reactions and pathways involving the molybdopterin cofactor (
synonym: "Moco metabolic process" EXACT []
synonym: "Moco metabolism" EXACT []
synonym: "molybdopterin cofactor metabolism" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
@@ -251375,7 +251439,6 @@ name: molybdopterin cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
synonym: "Moco binding" EXACT []
-is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
@@ -251806,7 +251869,7 @@ is_a: GO:0007423 ! sensory organ development
id: GO:0043584
name: nose development
namespace: biological_process
-def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/]
+def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl]
synonym: "nasus development" EXACT []
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0060541 ! respiratory system development
@@ -251815,7 +251878,7 @@ relationship: part_of GO:0060541 ! respiratory system development
id: GO:0043585
name: nose morphogenesis
namespace: biological_process
-def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/]
+def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl]
synonym: "nasus morphogenesis" EXACT []
is_a: GO:0090596 ! sensory organ morphogenesis
relationship: part_of GO:0043584 ! nose development
@@ -252038,7 +252101,7 @@ is_a: GO:1901566 ! organonitrogen compound biosynthetic process
id: GO:0043608
name: formamide catabolic process
namespace: biological_process
-def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]
+def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl]
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0043606 ! formamide metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
@@ -252215,7 +252278,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732]
synonym: "response to estrogen stimulus" EXACT [GOC:dos]
synonym: "response to oestrogen stimulus" EXACT []
-is_a: GO:0050896 ! response to stimulus
+is_a: GO:0009725 ! response to hormone
[Term]
id: GO:0043628
@@ -252305,8 +252368,6 @@ synonym: "bisphenol-A catabolic process" EXACT []
synonym: "bisphenol-A catabolism" EXACT []
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
-is_a: GO:0042447 ! hormone catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0043637
@@ -252334,10 +252395,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of benzoate
synonym: "benzoate breakdown" EXACT []
synonym: "benzoate catabolism" EXACT []
synonym: "benzoate degradation" EXACT []
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0018874 ! benzoate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -253077,6 +253136,7 @@ synonym: "2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity" EXA
synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT []
xref: KEGG_REACTION:R07394
xref: MetaCyc:R83-RXN
+xref: RHEA:14481
is_a: GO:0016791 ! phosphatase activity
[Term]
@@ -253086,6 +253146,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA." [MetaCyc:RXN-1083]
synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT []
xref: MetaCyc:RXN-1083
+xref: RHEA:42448
is_a: GO:0016836 ! hydro-lyase activity
[Term]
@@ -253118,6 +253179,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [MetaCyc:R125-RXN, PMID:13064]
synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT []
xref: MetaCyc:R125-RXN
+xref: RHEA:31555
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -253177,8 +253239,8 @@ namespace: molecular_function
alt_id: GO:0019173
def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl]
synonym: "pyrimidine phosphatase activity" EXACT [GOC:mah]
-xref: EC:3.1.3
xref: MetaCyc:RIBOPHOSPHAT-RXN
+xref: RHEA:25197
is_a: GO:0016791 ! phosphatase activity
[Term]
@@ -253218,6 +253280,7 @@ namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591]
xref: EC:1.14.13.114
xref: MetaCyc:RXN-7573
+xref: RHEA:27333
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -253339,6 +253402,7 @@ name: LPPG:FO 2-phospho-L-lactate transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [PMID:11888293]
xref: EC:2.7.8.28
+xref: RHEA:27510
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
[Term]
@@ -253450,6 +253514,7 @@ synonym: "dihydrolipoyl transacylase activity" EXACT [EC:2.3.1.168]
synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT []
xref: EC:2.3.1.168
xref: MetaCyc:2.3.1.168-RXN
+xref: RHEA:18865
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -253492,6 +253557,7 @@ synonym: "AdoCbi-P synthase activity" EXACT [EC:6.3.1.10]
synonym: "CbiB" RELATED []
xref: EC:6.3.1.10
xref: MetaCyc:RXN-6261
+xref: RHEA:21896
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity
[Term]
@@ -253577,6 +253643,7 @@ synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT []
synonym: "SepCysS" RELATED []
xref: EC:2.5.1.73
xref: MetaCyc:RXN-10719
+xref: RHEA:25686
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
relationship: part_of GO:0071952 ! conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA
@@ -253677,6 +253744,7 @@ synonym: "precorrin-6 methyltransferase activity" EXACT []
synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD []
synonym: "precorrin-6Y methylase" BROAD []
xref: MetaCyc:RXN-8766
+xref: RHEA:36067
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -253689,6 +253757,7 @@ synonym: "precorrin-6 methyltransferase" BROAD []
synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD []
synonym: "precorrin-6Y methylase" BROAD []
xref: MetaCyc:RXN-8767
+xref: RHEA:34591
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -253711,6 +253780,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde." [MetaCyc:RXN-8763]
synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT []
xref: MetaCyc:RXN-8763
+xref: RHEA:26281
is_a: GO:0016829 ! lyase activity
[Term]
@@ -253720,6 +253790,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [MetaCyc:RXN-8764]
synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT []
xref: MetaCyc:RXN-8764
+xref: RHEA:26285
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -253746,6 +253817,7 @@ synonym: "cobalt-precorrin-3 methylase" BROAD []
synonym: "cobalt-precorrin-3 methyltransferase" BROAD []
synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT []
xref: MetaCyc:RXN-8761
+xref: RHEA:26273
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -253803,6 +253875,7 @@ synonym: "MT1" BROAD []
synonym: "mtbB1" RELATED []
xref: EC:2.1.1.249
xref: MetaCyc:RXN-8100
+xref: RHEA:41175
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -253850,6 +253923,7 @@ name: glyceraldehyde dehydrogenase (NADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [EC:1.2.1.89]
xref: EC:1.2.1.89
+xref: RHEA:40163
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -253875,6 +253949,7 @@ synonym: "D-glycerate 2-kinase activity" EXACT []
synonym: "glycerate kinase" BROAD []
xref: EC:2.7.1
xref: MetaCyc:GKI-RXN
+xref: RHEA:27377
is_a: GO:0016301 ! kinase activity
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
@@ -253959,6 +254034,7 @@ synonym: "indolepyruvate oxidoreductase activity" EXACT [EC:1.2.7.8]
synonym: "IOR" RELATED []
xref: EC:1.2.7.8
xref: MetaCyc:1.2.7.8-RXN
+xref: RHEA:12645
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
[Term]
@@ -253990,6 +254066,7 @@ synonym: "ketoisovalerate oxidoreductase activity" EXACT [EC:1.2.7.7]
synonym: "VOR" RELATED []
xref: EC:1.2.7.7
xref: MetaCyc:1.2.7.7-RXN
+xref: RHEA:11712
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
[Term]
@@ -254023,7 +254100,6 @@ name: phosphatidylinositol-4-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [PMID:10224048]
synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT []
-xref: EC:3.1.3
is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity
is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity
@@ -254033,7 +254109,6 @@ name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [PMID:10806194, PMID:16607019]
synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT []
-xref: EC:3.1.3
xref: Reactome:R-HSA-1675836 "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane"
xref: Reactome:R-HSA-1676005 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane"
xref: Reactome:R-HSA-1676020 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane"
@@ -254049,6 +254124,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate." [PMID:18260642]
xref: EC:2.7.7.68
xref: MetaCyc:RXN-8077
+xref: RHEA:30519
is_a: GO:0070568 ! guanylyltransferase activity
[Term]
@@ -254061,6 +254137,7 @@ synonym: "formate-dependent GAR transformylase activity" EXACT []
synonym: "GAR transformylase 2" RELATED []
synonym: "GART 2" RELATED []
xref: MetaCyc:GARTRANSFORMYL2-RXN
+xref: RHEA:24829
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity
[Term]
@@ -254136,6 +254213,7 @@ def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + prop
synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT []
synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT []
xref: MetaCyc:RXN0-268
+xref: RHEA:28010
is_a: GO:0008410 ! CoA-transferase activity
[Term]
@@ -254157,6 +254235,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O." [PMID:16086104, PMID:16158287]
xref: EC:1.14.15.9
xref: MetaCyc:RXN-10670
+xref: RHEA:33027
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
[Term]
@@ -254229,6 +254308,7 @@ synonym: "B0503" RELATED []
synonym: "SelU" RELATED []
synonym: "YbbB" RELATED []
xref: MetaCyc:RXN0-2281
+xref: RHEA:42716
is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -254299,6 +254379,7 @@ synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase a
synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT []
xref: EC:2.1.1.250
xref: MetaCyc:RXN-8102
+xref: RHEA:39287
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -254332,6 +254413,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH." [PMID:10612726, PMID:2803248]
synonym: "ValDH" RELATED []
xref: EC:1.4.1.23
+xref: RHEA:30763
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
[Term]
@@ -254508,6 +254590,7 @@ synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT []
synonym: "MtmB" RELATED []
xref: EC:2.1.1.248
xref: MetaCyc:RXN-8098
+xref: RHEA:26059
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -254590,7 +254673,6 @@ namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200]
comment: This term was made obsolete because it represents a gene product.
synonym: "cyanophycinase activity" EXACT []
-xref: EC:3
is_obsolete: true
replaced_by: GO:0008236
@@ -254636,6 +254718,7 @@ synonym: "HHED aldolase activity" EXACT []
synonym: "HpaI" RELATED []
synonym: "HpcH" RELATED []
xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN
+xref: RHEA:25788
is_a: GO:0016832 ! aldehyde-lyase activity
[Term]
@@ -254650,6 +254733,7 @@ synonym: "indole-3-acetamide hydrolase activity" EXACT []
synonym: "Tms2" RELATED []
xref: EC:3.5.1.4
xref: MetaCyc:G-5841
+xref: RHEA:45048
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -254703,6 +254787,7 @@ synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT []
synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT []
synonym: "NAGSA dehydrogenase activity" BROAD []
xref: MetaCyc:RXN-5183
+xref: RHEA:41948
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -254714,6 +254799,7 @@ comment: This function is part of the pipecolate pathway of lysine catabolism.
synonym: "AmaB" RELATED []
synonym: "PIPOX" RELATED []
xref: MetaCyc:RXN-8162
+xref: RHEA:49476
is_a: GO:0016491 ! oxidoreductase activity
[Term]
@@ -254739,6 +254825,7 @@ def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-C
synonym: "NifJ" RELATED []
synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT []
xref: MetaCyc:PYFLAVOXRE-RXN
+xref: RHEA:44140
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
[Term]
@@ -254780,6 +254867,7 @@ synonym: "DtaAS" RELATED []
synonym: "low-specificity D-threonine aldolase" NARROW []
xref: EC:4.1.2.42
xref: MetaCyc:4.1.2.42-RXN
+xref: RHEA:15257
is_a: GO:0016832 ! aldehyde-lyase activity
[Term]
@@ -254803,6 +254891,7 @@ synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXAC
synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT []
xref: EC:1.2.1.3
xref: MetaCyc:RXN-3443
+xref: RHEA:25294
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -254877,6 +254966,7 @@ synonym: "ACS" RELATED [EC:2.3.1.169]
synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT []
xref: EC:2.3.1.169
xref: MetaCyc:ACETYLSYNCLTH-RXN
+xref: RHEA:45212
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -254901,11 +254991,12 @@ is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group
id: GO:0043886
name: structural constituent of carboxysome
namespace: molecular_function
-def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide." [GOC:jl]
+def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO(2)." [GOC:jl, PMID:28934381]
is_a: GO:0005198 ! structural molecule activity
intersection_of: GO:0005198 ! structural molecule activity
intersection_of: occurs_in GO:0031470 ! carboxysome
relationship: occurs_in GO:0031470 ! carboxysome
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19743 xsd:anyURI
[Term]
id: GO:0043887
@@ -255133,15 +255224,17 @@ relationship: positively_regulates GO:0051704 ! multi-organism process
[Term]
id: GO:0043903
-name: regulation of interspecies interactions between organisms
+name: regulation of symbiotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl]
+comment: regulation of interspecies interactions between organisms
+synonym: "regulation of interspecies interactions between organisms" BROAD []
synonym: "regulation of symbiosis, encompassing mutualism through parasitism" RELATED []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0044403 ! symbiotic process
relationship: regulates GO:0044403 ! symbiotic process
-property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19222 xsd:anyURI
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19028 xsd:anyURI
[Term]
id: GO:0043904
@@ -255152,6 +255245,7 @@ synonym: "IPL" EXACT []
synonym: "isochorismate-pyruvate lyase activity" EXACT []
xref: EC:4.2.99.21
xref: MetaCyc:RXN-1981
+xref: RHEA:27874
is_a: GO:0016835 ! carbon-oxygen lyase activity
[Term]
@@ -255354,7 +255448,7 @@ name: suramin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [GOC:jl, Wikipedia:Suramin]
synonym: "Germanin binding" EXACT []
-is_a: GO:0008144 ! drug binding
+is_a: GO:0033218 ! amide binding
is_a: GO:0043168 ! anion binding
is_a: GO:0043177 ! organic acid binding
is_a: GO:0097159 ! organic cyclic compound binding
@@ -255707,6 +255801,7 @@ synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:6.2.1.36
+xref: RHEA:26534
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity
@@ -255724,6 +255819,7 @@ synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BRO
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:4.2.1.116
xref: MetaCyc:RXN-6383
+xref: RHEA:26518
is_a: GO:0016836 ! hydro-lyase activity
[Term]
@@ -255756,6 +255852,7 @@ synonym: "acrylyl-CoA reductase (NADH)" EXACT []
synonym: "propionyl-CoA dehydrogenase" EXACT []
xref: EC:1.3.99.3
xref: MetaCyc:RXN-8568
+xref: RHEA:34471
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -255784,6 +255881,7 @@ synonym: "succinyl-CoA:(R)-citramalate CoA transferase activity" EXACT []
synonym: "succinyl-CoA:R-citramalate CoA transferase" EXACT []
xref: EC:2.8.3.20
xref: MetaCyc:RXN-8966
+xref: RHEA:38279
is_a: GO:0008410 ! CoA-transferase activity
[Term]
@@ -257358,11 +257456,11 @@ creation_date: 2009-08-04T03:36:02Z
[Term]
id: GO:0044133
-name: growth of symbiont on or near host
+name: obsolete growth of symbiont on or near host
namespace: biological_process
-def: "The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]
-comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'development of symbiont on or near host ; GO:0044132'.
-is_a: GO:0044110 ! growth involved in symbiotic interaction
+def: "OBSOLETE. The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]
+comment: This term was obsoleted because it represented both a process and a location.
+is_obsolete: true
created_by: jl
creation_date: 2009-08-04T03:36:49Z
@@ -257489,7 +257587,7 @@ def: "Any process that modulates the frequency, rate or extent of the progressio
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'.
synonym: "modulation of development of symbiont during interaction with host" RELATED [GOC:dph]
is_a: GO:0043900 ! regulation of multi-organism process
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0044115 ! development of symbiont involved in interaction with host
created_by: jl
@@ -260732,10 +260830,9 @@ creation_date: 2012-01-12T03:14:19Z
id: GO:0044466
name: glutaryl-CoA hydrolase activity
namespace: molecular_function
-def: "Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate." [GOC:pm, PMID:16141203, RHEA:13389]
+def: "Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate." [GOC:pm, PMID:16141203]
synonym: "glutaryl-CoA thioesterase activity" EXACT []
-xref: EC:1.3.8.6
-xref: RHEA:13389
+xref: EC:3.1.2.3
is_a: GO:0047617 ! acyl-CoA hydrolase activity
created_by: jl
creation_date: 2012-01-17T04:16:43Z
@@ -262010,7 +262107,6 @@ id: GO:0044589
name: pectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pectin." [GOC:mengo_curators, GOC:tt]
-is_a: GO:0008144 ! drug binding
is_a: GO:0048028 ! galacturonan binding
created_by: jl
creation_date: 2012-04-26T01:26:56Z
@@ -262022,7 +262118,7 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691]
synonym: "FeMo co binding" EXACT []
synonym: "FeMoco binding" EXACT []
-is_a: GO:0048037 ! cofactor binding
+is_a: GO:0005488 ! binding
created_by: jl
creation_date: 2012-04-26T02:27:39Z
@@ -262055,7 +262151,7 @@ synonym: "FeMoco biosynthetic process" EXACT []
synonym: "iron molybdenum cofactor assembly" EXACT []
synonym: "iron molybdenum cofactor biosynthesis" EXACT []
synonym: "iron molybdenum cofactor biosynthetic process" EXACT []
-is_a: GO:0051188 ! cofactor biosynthetic process
+is_a: GO:0016226 ! iron-sulfur cluster assembly
created_by: jl
creation_date: 2012-04-26T04:01:53Z
@@ -262088,6 +262184,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-10 = S-adenosyl-L-homocysteine + ubiquinol-10." [PMID:10777520]
xref: MetaCyc:RXN-9237
xref: Reactome:R-HSA-2162186 "DeMQ10H2 is methylated to Q10H2 by COQ3"
+xref: RHEA:44412
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0061542 ! 3-demethylubiquinol-n 3-O-methyltransferase activity
created_by: jl
@@ -262115,7 +262212,6 @@ def: "The chemical reactions and pathways involving doxorubicin, an anthracyclin
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0016137 ! glycoside metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -262255,7 +262351,6 @@ def: "Enables the directed movement of flavine mononucleotide (FMN) from one sid
synonym: "flavine mononucleotide transmembrane transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity
created_by: jl
creation_date: 2012-05-30T03:09:19Z
@@ -263033,6 +263128,7 @@ name: dihydromethanopterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP." [GOC:mengo_curators, PMID:15028691]
xref: EC:1.5.99.15
+xref: RHEA:42804
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
relationship: part_of GO:2001118 ! tetrahydromethanopterin biosynthetic process
created_by: jl
@@ -263455,7 +263551,7 @@ name: acid-sensing ion channel activity
namespace: molecular_function
def: "Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex." [GOC:jl]
synonym: "ASIC activity" EXACT []
-xref: Reactome:R-HSA-2671885 "ASICs transport extracellular Na+ to cytosol"
+xref: Reactome:R-HSA-2671885 "ASIC trimers:H+ transport extracellular Na+ to cytosol"
xref: Wikipedia:Acid-sensing_ion_channel
is_a: GO:0015280 ! ligand-gated sodium channel activity
created_by: jl
@@ -264819,12 +264915,16 @@ creation_date: 2014-11-25T16:30:30Z
[Term]
id: GO:0044875
-name: gamma-glutamyl hercynylcysteine sulfoxide synthase
+name: gamma-glutamyl hercynylcysteine sulfoxide synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O." [GOC:jl, PMID:24828577]
+def: "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O." [GOC:jl, PMID:24828577, RHEA:42672]
synonym: "gamma-glutamyl hercynylcysteine S-oxide synthase" EXACT [GOC:dph]
-xref: EC:1.14.99
+synonym: "gamma-glutamyl hercynylcysteine sulfoxide synthase" EXACT []
+xref: EC:1.14.99.50
+xref: RHEA:42672
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
+relationship: part_of GO:0052704 ! ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/11163 xsd:anyURI
created_by: jl
creation_date: 2014-12-15T11:44:54Z
@@ -265095,7 +265195,7 @@ def: "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and
comment: This term was made obsolete because it represents a gene product.
synonym: "peptidyl-glutamyl peptide hydrolyzing enzyme activity" EXACT []
is_obsolete: true
-replaced_by: GO:0070011
+replaced_by: GO:0008233
[Term]
id: GO:0045025
@@ -265601,21 +265701,6 @@ intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0019079 ! viral genome replication
relationship: negatively_regulates GO:0019079 ! viral genome replication
-[Term]
-id: GO:0045072
-name: regulation of interferon-gamma biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
-synonym: "regulation of interferon-gamma anabolism" EXACT []
-synonym: "regulation of interferon-gamma biosynthesis" EXACT []
-synonym: "regulation of interferon-gamma formation" EXACT []
-synonym: "regulation of interferon-gamma synthesis" EXACT []
-is_a: GO:0032649 ! regulation of interferon-gamma production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042095 ! interferon-gamma biosynthetic process
-relationship: regulates GO:0042095 ! interferon-gamma biosynthetic process
-
[Term]
id: GO:0045073
name: regulation of chemokine biosynthetic process
@@ -265631,98 +265716,6 @@ intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0042033 ! chemokine biosynthetic process
relationship: regulates GO:0042033 ! chemokine biosynthetic process
-[Term]
-id: GO:0045074
-name: regulation of interleukin-10 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
-synonym: "regulation of IL-10 biosynthesis" EXACT []
-synonym: "regulation of IL-10 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-10 anabolism" EXACT []
-synonym: "regulation of interleukin-10 biosynthesis" EXACT []
-synonym: "regulation of interleukin-10 formation" EXACT []
-synonym: "regulation of interleukin-10 synthesis" EXACT []
-is_a: GO:0032653 ! regulation of interleukin-10 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042091 ! interleukin-10 biosynthetic process
-relationship: regulates GO:0042091 ! interleukin-10 biosynthetic process
-
-[Term]
-id: GO:0045075
-name: regulation of interleukin-12 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
-synonym: "regulation of IL-12 biosynthesis" EXACT []
-synonym: "regulation of IL-12 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-12 anabolism" EXACT []
-synonym: "regulation of interleukin-12 biosynthesis" EXACT []
-synonym: "regulation of interleukin-12 formation" EXACT []
-synonym: "regulation of interleukin-12 synthesis" EXACT []
-is_a: GO:0032655 ! regulation of interleukin-12 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042090 ! interleukin-12 biosynthetic process
-relationship: regulates GO:0042090 ! interleukin-12 biosynthetic process
-
-[Term]
-id: GO:0045076
-name: regulation of interleukin-2 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
-synonym: "regulation of IL-2 biosynthesis" EXACT []
-synonym: "regulation of IL-2 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-2 anabolism" EXACT []
-synonym: "regulation of interleukin-2 biosynthesis" EXACT []
-synonym: "regulation of interleukin-2 formation" EXACT []
-synonym: "regulation of interleukin-2 synthesis" EXACT []
-is_a: GO:0032663 ! regulation of interleukin-2 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042094 ! interleukin-2 biosynthetic process
-relationship: regulates GO:0042094 ! interleukin-2 biosynthetic process
-
-[Term]
-id: GO:0045077
-name: negative regulation of interferon-gamma biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
-synonym: "down regulation of interferon-gamma biosynthetic process" EXACT []
-synonym: "down-regulation of interferon-gamma biosynthetic process" EXACT []
-synonym: "downregulation of interferon-gamma biosynthetic process" EXACT []
-synonym: "inhibition of interferon-gamma biosynthetic process" NARROW []
-synonym: "negative regulation of interferon-gamma anabolism" EXACT []
-synonym: "negative regulation of interferon-gamma biosynthesis" EXACT []
-synonym: "negative regulation of interferon-gamma formation" EXACT []
-synonym: "negative regulation of interferon-gamma synthesis" EXACT []
-is_a: GO:0032689 ! negative regulation of interferon-gamma production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process
-relationship: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process
-
-[Term]
-id: GO:0045078
-name: positive regulation of interferon-gamma biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
-synonym: "activation of interferon-gamma biosynthetic process" NARROW []
-synonym: "positive regulation of interferon-gamma anabolism" EXACT []
-synonym: "positive regulation of interferon-gamma biosynthesis" EXACT []
-synonym: "positive regulation of interferon-gamma formation" EXACT []
-synonym: "positive regulation of interferon-gamma synthesis" EXACT []
-synonym: "stimulation of interferon-gamma biosynthetic process" NARROW []
-synonym: "up regulation of interferon-gamma biosynthetic process" EXACT []
-synonym: "up-regulation of interferon-gamma biosynthetic process" EXACT []
-synonym: "upregulation of interferon-gamma biosynthetic process" EXACT []
-is_a: GO:0032729 ! positive regulation of interferon-gamma production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process
-relationship: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process
-
[Term]
id: GO:0045079
name: negative regulation of chemokine biosynthetic process
@@ -265764,141 +265757,6 @@ intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0042033 ! chemokine biosynthetic process
relationship: positively_regulates GO:0042033 ! chemokine biosynthetic process
-[Term]
-id: GO:0045081
-name: negative regulation of interleukin-10 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
-synonym: "down regulation of interleukin-10 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-10 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-10 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-10 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-10 biosynthesis" EXACT []
-synonym: "negative regulation of IL-10 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-10 anabolism" EXACT []
-synonym: "negative regulation of interleukin-10 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-10 formation" EXACT []
-synonym: "negative regulation of interleukin-10 synthesis" EXACT []
-is_a: GO:0032693 ! negative regulation of interleukin-10 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process
-relationship: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process
-
-[Term]
-id: GO:0045082
-name: positive regulation of interleukin-10 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
-synonym: "activation of interleukin-10 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-10 biosynthesis" EXACT []
-synonym: "positive regulation of IL-10 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-10 anabolism" EXACT []
-synonym: "positive regulation of interleukin-10 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-10 formation" EXACT []
-synonym: "positive regulation of interleukin-10 synthesis" EXACT []
-synonym: "stimulation of interleukin-10 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-10 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-10 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-10 biosynthetic process" EXACT []
-is_a: GO:0032733 ! positive regulation of interleukin-10 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process
-relationship: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process
-
-[Term]
-id: GO:0045083
-name: negative regulation of interleukin-12 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
-synonym: "down regulation of interleukin-12 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-12 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-12 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-12 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-12 biosynthesis" EXACT []
-synonym: "negative regulation of IL-12 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-12 anabolism" EXACT []
-synonym: "negative regulation of interleukin-12 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-12 formation" EXACT []
-synonym: "negative regulation of interleukin-12 synthesis" EXACT []
-is_a: GO:0032695 ! negative regulation of interleukin-12 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process
-relationship: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process
-
-[Term]
-id: GO:0045084
-name: positive regulation of interleukin-12 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
-synonym: "activation of interleukin-12 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-12 biosynthesis" EXACT []
-synonym: "positive regulation of IL-12 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-12 anabolism" EXACT []
-synonym: "positive regulation of interleukin-12 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-12 formation" EXACT []
-synonym: "positive regulation of interleukin-12 synthesis" EXACT []
-synonym: "stimulation of interleukin-12 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-12 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-12 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-12 biosynthetic process" EXACT []
-is_a: GO:0032735 ! positive regulation of interleukin-12 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process
-relationship: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process
-
-[Term]
-id: GO:0045085
-name: negative regulation of interleukin-2 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
-synonym: "down regulation of interleukin-2 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-2 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-2 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-2 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-2 biosynthesis" EXACT []
-synonym: "negative regulation of IL-2 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-2 anabolism" EXACT []
-synonym: "negative regulation of interleukin-2 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-2 formation" EXACT []
-synonym: "negative regulation of interleukin-2 synthesis" EXACT []
-is_a: GO:0032703 ! negative regulation of interleukin-2 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process
-relationship: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process
-
-[Term]
-id: GO:0045086
-name: positive regulation of interleukin-2 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
-synonym: "activation of interleukin-2 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-2 biosynthesis" EXACT []
-synonym: "positive regulation of IL-2 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-2 anabolism" EXACT []
-synonym: "positive regulation of interleukin-2 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-2 formation" EXACT []
-synonym: "positive regulation of interleukin-2 synthesis" EXACT []
-synonym: "stimulation of interleukin-2 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-2 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-2 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-2 biosynthetic process" EXACT []
-is_a: GO:0032743 ! positive regulation of interleukin-2 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process
-relationship: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process
-
[Term]
id: GO:0045087
name: innate immune response
@@ -266458,8 +266316,9 @@ replaced_by: GO:0046688
id: GO:0045140
name: inositol phosphoceramide synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [MetaCyc:RXN3O-581, PMID:9405490, PMID:9614099]
+def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol." [PMID:9405490, PMID:9614099]
synonym: "IPC synthase activity" EXACT []
+xref: EC:2.7.1.227
xref: MetaCyc:RXN3O-581
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -266809,7 +266668,7 @@ synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" EXACT [EC:1.
xref: EC:1.8.5.1
xref: KEGG_REACTION:R01108
xref: MetaCyc:1.8.5.1-RXN
-xref: Reactome:R-HSA-198813 "2xGSTOs reduce DHvitC to VitC"
+xref: Reactome:R-HSA-198813 "GSTO dimers reduce DeHA to AscH-"
xref: RHEA:24424
is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity
is_a: GO:0016209 ! antioxidant activity
@@ -266959,17 +266818,16 @@ relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep
[Term]
id: GO:0045189
-name: connective tissue growth factor biosynthetic process
+name: obsolete connective tissue growth factor biosynthetic process
namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [http://www.copewithcytokines.de]
+def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [GOC:curators]
+comment: This term was obsoleted because it represent translation of a gene product, not a specific process.
synonym: "connective tissue growth factor anabolism" EXACT []
synonym: "connective tissue growth factor biosynthesis" EXACT []
synonym: "connective tissue growth factor formation" EXACT []
synonym: "connective tissue growth factor synthesis" EXACT []
synonym: "CTGF biosynthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032601 ! connective tissue growth factor production
+is_obsolete: true
[Term]
id: GO:0045190
@@ -267289,7 +267147,7 @@ is_a: GO:0034334 ! adherens junction maintenance
[Term]
id: GO:0045219
-name: regulation of FasL biosynthetic process
+name: regulation of FasL production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "regulation of FasL anabolism" EXACT []
@@ -267303,12 +267161,13 @@ relationship: regulates GO:0045210 ! FasL biosynthetic process
[Term]
id: GO:0045220
-name: positive regulation of FasL biosynthetic process
+name: positive regulation of FasL production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "activation of FasL biosynthetic process" NARROW []
synonym: "positive regulation of FasL anabolism" EXACT []
synonym: "positive regulation of FasL biosynthesis" EXACT []
+synonym: "positive regulation of FasL biosynthetic process" EXACT []
synonym: "positive regulation of FasL formation" EXACT []
synonym: "positive regulation of FasL synthesis" EXACT []
synonym: "stimulation of FasL biosynthetic process" NARROW []
@@ -267316,14 +267175,14 @@ synonym: "up regulation of FasL biosynthetic process" EXACT []
synonym: "up-regulation of FasL biosynthetic process" EXACT []
synonym: "upregulation of FasL biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
-is_a: GO:0045219 ! regulation of FasL biosynthetic process
+is_a: GO:0045219 ! regulation of FasL production
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0045210 ! FasL biosynthetic process
relationship: positively_regulates GO:0045210 ! FasL biosynthetic process
[Term]
id: GO:0045221
-name: negative regulation of FasL biosynthetic process
+name: negative regulation of FasL production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "down regulation of FasL biosynthetic process" EXACT []
@@ -267332,10 +267191,11 @@ synonym: "downregulation of FasL biosynthetic process" EXACT []
synonym: "inhibition of FasL biosynthetic process" NARROW []
synonym: "negative regulation of FasL anabolism" EXACT []
synonym: "negative regulation of FasL biosynthesis" EXACT []
+synonym: "negative regulation of FasL biosynthetic process" EXACT []
synonym: "negative regulation of FasL formation" EXACT []
synonym: "negative regulation of FasL synthesis" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
-is_a: GO:0045219 ! regulation of FasL biosynthetic process
+is_a: GO:0045219 ! regulation of FasL production
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0045210 ! FasL biosynthetic process
relationship: negatively_regulates GO:0045210 ! FasL biosynthetic process
@@ -267353,11 +267213,12 @@ is_a: GO:0009101 ! glycoprotein biosynthetic process
[Term]
id: GO:0045223
-name: regulation of CD4 biosynthetic process
+name: regulation of CD4 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "regulation of CD4 anabolism" EXACT []
synonym: "regulation of CD4 biosynthesis" EXACT []
+synonym: "regulation of CD4 biosynthetic process" EXACT []
synonym: "regulation of CD4 formation" EXACT []
synonym: "regulation of CD4 synthesis" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
@@ -267367,12 +267228,13 @@ relationship: regulates GO:0045222 ! CD4 biosynthetic process
[Term]
id: GO:0045224
-name: positive regulation of CD4 biosynthetic process
+name: positive regulation of CD4 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "activation of CD4 biosynthetic process" NARROW []
synonym: "positive regulation of CD4 anabolism" EXACT []
synonym: "positive regulation of CD4 biosynthesis" EXACT []
+synonym: "positive regulation of CD4 biosynthetic process" EXACT []
synonym: "positive regulation of CD4 formation" EXACT []
synonym: "positive regulation of CD4 synthesis" EXACT []
synonym: "stimulation of CD4 biosynthetic process" NARROW []
@@ -267380,14 +267242,14 @@ synonym: "up regulation of CD4 biosynthetic process" EXACT []
synonym: "up-regulation of CD4 biosynthetic process" EXACT []
synonym: "upregulation of CD4 biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
-is_a: GO:0045223 ! regulation of CD4 biosynthetic process
+is_a: GO:0045223 ! regulation of CD4 production
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0045222 ! CD4 biosynthetic process
relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process
[Term]
id: GO:0045225
-name: negative regulation of CD4 biosynthetic process
+name: negative regulation of CD4 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "down regulation of CD4 biosynthetic process" EXACT []
@@ -267396,10 +267258,11 @@ synonym: "downregulation of CD4 biosynthetic process" EXACT []
synonym: "inhibition of CD4 biosynthetic process" NARROW []
synonym: "negative regulation of CD4 anabolism" EXACT []
synonym: "negative regulation of CD4 biosynthesis" EXACT []
+synonym: "negative regulation of CD4 biosynthetic process" EXACT []
synonym: "negative regulation of CD4 formation" EXACT []
synonym: "negative regulation of CD4 synthesis" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
-is_a: GO:0045223 ! regulation of CD4 biosynthetic process
+is_a: GO:0045223 ! regulation of CD4 production
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0045222 ! CD4 biosynthetic process
relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process
@@ -268686,49 +268549,6 @@ intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0045342 ! MHC class II biosynthetic process
relationship: positively_regulates GO:0045342 ! MHC class II biosynthetic process
-[Term]
-id: GO:0045349
-name: interferon-alpha biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
-synonym: "IFN-alpha biosynthesis" EXACT []
-synonym: "IFN-alpha biosynthetic process" EXACT []
-synonym: "interferon-alpha anabolism" EXACT []
-synonym: "interferon-alpha biosynthesis" EXACT []
-synonym: "interferon-alpha formation" EXACT []
-synonym: "interferon-alpha synthesis" EXACT []
-is_a: GO:0045351 ! type I interferon biosynthetic process
-relationship: part_of GO:0032607 ! interferon-alpha production
-
-[Term]
-id: GO:0045350
-name: interferon-beta biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
-synonym: "IFN-beta biosynthesis" EXACT []
-synonym: "IFN-beta biosynthetic process" EXACT []
-synonym: "IFNB biosynthetic process" EXACT [GOC:mah]
-synonym: "interferon-beta anabolism" EXACT []
-synonym: "interferon-beta biosynthesis" EXACT []
-synonym: "interferon-beta formation" EXACT []
-synonym: "interferon-beta synthesis" EXACT []
-is_a: GO:0045351 ! type I interferon biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032608 ! interferon-beta production
-
-[Term]
-id: GO:0045351
-name: type I interferon biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add]
-synonym: "interferon type I biosynthetic process" EXACT []
-synonym: "type I interferon anabolism" EXACT []
-synonym: "type I interferon biosynthesis" EXACT []
-synonym: "type I interferon formation" EXACT []
-synonym: "type I interferon synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-relationship: part_of GO:0032606 ! type I interferon production
-
[Term]
id: GO:0045352
name: interleukin-1 type I receptor antagonist activity
@@ -268745,1414 +268565,6 @@ def: "Blocks the binding of interleukin-1 to interleukin-1 type II receptors." [
synonym: "IL-1ra type II" EXACT []
is_a: GO:0005152 ! interleukin-1 receptor antagonist activity
-[Term]
-id: GO:0045354
-name: regulation of interferon-alpha biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
-synonym: "regulation of interferon-alpha anabolism" EXACT []
-synonym: "regulation of interferon-alpha biosynthesis" EXACT []
-synonym: "regulation of interferon-alpha formation" EXACT []
-synonym: "regulation of interferon-alpha synthesis" EXACT []
-is_a: GO:0032647 ! regulation of interferon-alpha production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0045349 ! interferon-alpha biosynthetic process
-relationship: regulates GO:0045349 ! interferon-alpha biosynthetic process
-
-[Term]
-id: GO:0045355
-name: negative regulation of interferon-alpha biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
-synonym: "down regulation of interferon-alpha biosynthetic process" EXACT []
-synonym: "down-regulation of interferon-alpha biosynthetic process" EXACT []
-synonym: "downregulation of interferon-alpha biosynthetic process" EXACT []
-synonym: "inhibition of interferon-alpha biosynthetic process" NARROW []
-synonym: "negative regulation of interferon-alpha anabolism" EXACT []
-synonym: "negative regulation of interferon-alpha biosynthesis" EXACT []
-synonym: "negative regulation of interferon-alpha formation" EXACT []
-synonym: "negative regulation of interferon-alpha synthesis" EXACT []
-is_a: GO:0032687 ! negative regulation of interferon-alpha production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process
-relationship: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process
-
-[Term]
-id: GO:0045356
-name: positive regulation of interferon-alpha biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
-synonym: "activation of interferon-alpha biosynthetic process" NARROW []
-synonym: "positive regulation of interferon-alpha anabolism" EXACT []
-synonym: "positive regulation of interferon-alpha biosynthesis" EXACT []
-synonym: "positive regulation of interferon-alpha formation" EXACT []
-synonym: "positive regulation of interferon-alpha synthesis" EXACT []
-synonym: "stimulation of interferon-alpha biosynthetic process" NARROW []
-synonym: "up regulation of interferon-alpha biosynthetic process" EXACT []
-synonym: "up-regulation of interferon-alpha biosynthetic process" EXACT []
-synonym: "upregulation of interferon-alpha biosynthetic process" EXACT []
-is_a: GO:0032727 ! positive regulation of interferon-alpha production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process
-relationship: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process
-
-[Term]
-id: GO:0045357
-name: regulation of interferon-beta biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
-synonym: "regulation of interferon-beta anabolism" EXACT []
-synonym: "regulation of interferon-beta biosynthesis" EXACT []
-synonym: "regulation of interferon-beta formation" EXACT []
-synonym: "regulation of interferon-beta synthesis" EXACT []
-is_a: GO:0032648 ! regulation of interferon-beta production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0045350 ! interferon-beta biosynthetic process
-relationship: regulates GO:0045350 ! interferon-beta biosynthetic process
-
-[Term]
-id: GO:0045358
-name: negative regulation of interferon-beta biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
-synonym: "down regulation of interferon-beta biosynthetic process" EXACT []
-synonym: "down-regulation of interferon-beta biosynthetic process" EXACT []
-synonym: "downregulation of interferon-beta biosynthetic process" EXACT []
-synonym: "inhibition of interferon-beta biosynthetic process" NARROW []
-synonym: "negative regulation of interferon-beta anabolism" EXACT []
-synonym: "negative regulation of interferon-beta biosynthesis" EXACT []
-synonym: "negative regulation of interferon-beta formation" EXACT []
-synonym: "negative regulation of interferon-beta synthesis" EXACT []
-is_a: GO:0032688 ! negative regulation of interferon-beta production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process
-relationship: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process
-
-[Term]
-id: GO:0045359
-name: positive regulation of interferon-beta biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
-synonym: "activation of interferon-beta biosynthetic process" NARROW []
-synonym: "positive regulation of interferon-beta anabolism" EXACT []
-synonym: "positive regulation of interferon-beta biosynthesis" EXACT []
-synonym: "positive regulation of interferon-beta formation" EXACT []
-synonym: "positive regulation of interferon-beta synthesis" EXACT []
-synonym: "stimulation of interferon-beta biosynthetic process" NARROW []
-synonym: "up regulation of interferon-beta biosynthetic process" EXACT []
-synonym: "up-regulation of interferon-beta biosynthetic process" EXACT []
-synonym: "upregulation of interferon-beta biosynthetic process" EXACT []
-is_a: GO:0032728 ! positive regulation of interferon-beta production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0045350 ! interferon-beta biosynthetic process
-relationship: positively_regulates GO:0045350 ! interferon-beta biosynthetic process
-
-[Term]
-id: GO:0045360
-name: regulation of interleukin-1 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]
-synonym: "regulation of IL-1 biosynthesis" EXACT []
-synonym: "regulation of IL-1 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-1 anabolism" EXACT []
-synonym: "regulation of interleukin-1 biosynthesis" EXACT []
-synonym: "regulation of interleukin-1 formation" EXACT []
-synonym: "regulation of interleukin-1 synthesis" EXACT []
-is_a: GO:0032652 ! regulation of interleukin-1 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042222 ! interleukin-1 biosynthetic process
-relationship: regulates GO:0042222 ! interleukin-1 biosynthetic process
-
-[Term]
-id: GO:0045361
-name: negative regulation of interleukin-1 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]
-synonym: "down regulation of interleukin-1 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-1 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-1 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-1 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-1 biosynthesis" EXACT []
-synonym: "negative regulation of IL-1 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-1 anabolism" EXACT []
-synonym: "negative regulation of interleukin-1 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-1 formation" EXACT []
-synonym: "negative regulation of interleukin-1 synthesis" EXACT []
-is_a: GO:0032692 ! negative regulation of interleukin-1 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process
-relationship: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process
-
-[Term]
-id: GO:0045362
-name: positive regulation of interleukin-1 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]
-synonym: "activation of interleukin-1 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-1 biosynthesis" EXACT []
-synonym: "positive regulation of IL-1 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-1 anabolism" EXACT []
-synonym: "positive regulation of interleukin-1 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-1 formation" EXACT []
-synonym: "positive regulation of interleukin-1 synthesis" EXACT []
-synonym: "stimulation of interleukin-1 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-1 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-1 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-1 biosynthetic process" EXACT []
-is_a: GO:0032732 ! positive regulation of interleukin-1 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process
-relationship: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process
-
-[Term]
-id: GO:0045363
-name: regulation of interleukin-11 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
-synonym: "regulation of IL-11 biosynthesis" EXACT []
-synonym: "regulation of IL-11 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-11 anabolism" EXACT []
-synonym: "regulation of interleukin-11 biosynthesis" EXACT []
-synonym: "regulation of interleukin-11 formation" EXACT []
-synonym: "regulation of interleukin-11 synthesis" EXACT []
-is_a: GO:0032654 ! regulation of interleukin-11 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042230 ! interleukin-11 biosynthetic process
-relationship: regulates GO:0042230 ! interleukin-11 biosynthetic process
-
-[Term]
-id: GO:0045364
-name: negative regulation of interleukin-11 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
-synonym: "down regulation of interleukin-11 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-11 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-11 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-11 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-11 biosynthesis" EXACT []
-synonym: "negative regulation of IL-11 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-11 anabolism" EXACT []
-synonym: "negative regulation of interleukin-11 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-11 formation" EXACT []
-synonym: "negative regulation of interleukin-11 synthesis" EXACT []
-is_a: GO:0032694 ! negative regulation of interleukin-11 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process
-relationship: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process
-
-[Term]
-id: GO:0045365
-name: positive regulation of interleukin-11 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
-synonym: "activation of interleukin-11 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-11 biosynthesis" EXACT []
-synonym: "positive regulation of IL-11 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-11 anabolism" EXACT []
-synonym: "positive regulation of interleukin-11 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-11 formation" EXACT []
-synonym: "positive regulation of interleukin-11 synthesis" EXACT []
-synonym: "stimulation of interleukin-11 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-11 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-11 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-11 biosynthetic process" EXACT []
-is_a: GO:0032734 ! positive regulation of interleukin-11 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process
-relationship: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process
-
-[Term]
-id: GO:0045366
-name: regulation of interleukin-13 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
-synonym: "regulation of IL-13 biosynthesis" EXACT []
-synonym: "regulation of IL-13 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-13 anabolism" EXACT []
-synonym: "regulation of interleukin-13 biosynthesis" EXACT []
-synonym: "regulation of interleukin-13 formation" EXACT []
-synonym: "regulation of interleukin-13 synthesis" EXACT []
-is_a: GO:0032656 ! regulation of interleukin-13 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042231 ! interleukin-13 biosynthetic process
-relationship: regulates GO:0042231 ! interleukin-13 biosynthetic process
-
-[Term]
-id: GO:0045367
-name: negative regulation of interleukin-13 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
-synonym: "down regulation of interleukin-13 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-13 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-13 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-13 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-13 biosynthesis" EXACT []
-synonym: "negative regulation of IL-13 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-13 anabolism" EXACT []
-synonym: "negative regulation of interleukin-13 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-13 formation" EXACT []
-synonym: "negative regulation of interleukin-13 synthesis" EXACT []
-is_a: GO:0032696 ! negative regulation of interleukin-13 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process
-relationship: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process
-
-[Term]
-id: GO:0045368
-name: positive regulation of interleukin-13 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
-synonym: "activation of interleukin-13 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-13 biosynthesis" EXACT []
-synonym: "positive regulation of IL-13 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-13 anabolism" EXACT []
-synonym: "positive regulation of interleukin-13 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-13 formation" EXACT []
-synonym: "positive regulation of interleukin-13 synthesis" EXACT []
-synonym: "stimulation of interleukin-13 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-13 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-13 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-13 biosynthetic process" EXACT []
-is_a: GO:0032736 ! positive regulation of interleukin-13 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process
-relationship: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process
-
-[Term]
-id: GO:0045369
-name: regulation of interleukin-14 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
-synonym: "regulation of IL-14 biosynthesis" EXACT []
-synonym: "regulation of IL-14 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-14 anabolism" EXACT []
-synonym: "regulation of interleukin-14 biosynthesis" EXACT []
-synonym: "regulation of interleukin-14 formation" EXACT []
-synonym: "regulation of interleukin-14 synthesis" EXACT []
-is_a: GO:0032657 ! regulation of interleukin-14 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042232 ! interleukin-14 biosynthetic process
-relationship: regulates GO:0042232 ! interleukin-14 biosynthetic process
-
-[Term]
-id: GO:0045370
-name: negative regulation of interleukin-14 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
-synonym: "down regulation of interleukin-14 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-14 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-14 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-14 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-14 biosynthesis" EXACT []
-synonym: "negative regulation of IL-14 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-14 anabolism" EXACT []
-synonym: "negative regulation of interleukin-14 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-14 formation" EXACT []
-synonym: "negative regulation of interleukin-14 synthesis" EXACT []
-is_a: GO:0032697 ! negative regulation of interleukin-14 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process
-relationship: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process
-
-[Term]
-id: GO:0045371
-name: positive regulation of interleukin-14 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
-synonym: "activation of interleukin-14 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-14 biosynthesis" EXACT []
-synonym: "positive regulation of IL-14 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-14 anabolism" EXACT []
-synonym: "positive regulation of interleukin-14 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-14 formation" EXACT []
-synonym: "positive regulation of interleukin-14 synthesis" EXACT []
-synonym: "stimulation of interleukin-14 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-14 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-14 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-14 biosynthetic process" EXACT []
-is_a: GO:0032737 ! positive regulation of interleukin-14 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process
-relationship: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process
-
-[Term]
-id: GO:0045372
-name: regulation of interleukin-15 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
-synonym: "regulation of IL-15 biosynthesis" EXACT []
-synonym: "regulation of IL-15 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-15 anabolism" EXACT []
-synonym: "regulation of interleukin-15 biosynthesis" EXACT []
-synonym: "regulation of interleukin-15 formation" EXACT []
-synonym: "regulation of interleukin-15 synthesis" EXACT []
-is_a: GO:0032658 ! regulation of interleukin-15 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042233 ! interleukin-15 biosynthetic process
-relationship: regulates GO:0042233 ! interleukin-15 biosynthetic process
-
-[Term]
-id: GO:0045373
-name: negative regulation of interleukin-15 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
-synonym: "down regulation of interleukin-15 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-15 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-15 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-15 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-15 biosynthesis" EXACT []
-synonym: "negative regulation of IL-15 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-15 anabolism" EXACT []
-synonym: "negative regulation of interleukin-15 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-15 formation" EXACT []
-synonym: "negative regulation of interleukin-15 synthesis" EXACT []
-is_a: GO:0032698 ! negative regulation of interleukin-15 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process
-relationship: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process
-
-[Term]
-id: GO:0045374
-name: positive regulation of interleukin-15 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
-synonym: "activation of interleukin-15 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-15 biosynthesis" EXACT []
-synonym: "positive regulation of IL-15 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-15 anabolism" EXACT []
-synonym: "positive regulation of interleukin-15 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-15 formation" EXACT []
-synonym: "positive regulation of interleukin-15 synthesis" EXACT []
-synonym: "stimulation of interleukin-15 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-15 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-15 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-15 biosynthetic process" EXACT []
-is_a: GO:0032738 ! positive regulation of interleukin-15 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process
-relationship: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process
-
-[Term]
-id: GO:0045375
-name: regulation of interleukin-16 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
-synonym: "regulation of IL-16 biosynthesis" EXACT []
-synonym: "regulation of IL-16 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-16 anabolism" EXACT []
-synonym: "regulation of interleukin-16 biosynthesis" EXACT []
-synonym: "regulation of interleukin-16 formation" EXACT []
-synonym: "regulation of interleukin-16 synthesis" EXACT []
-is_a: GO:0032659 ! regulation of interleukin-16 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042234 ! interleukin-16 biosynthetic process
-relationship: regulates GO:0042234 ! interleukin-16 biosynthetic process
-
-[Term]
-id: GO:0045376
-name: negative regulation of interleukin-16 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
-synonym: "down regulation of interleukin-16 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-16 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-16 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-16 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-16 biosynthesis" EXACT []
-synonym: "negative regulation of IL-16 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-16 anabolism" EXACT []
-synonym: "negative regulation of interleukin-16 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-16 formation" EXACT []
-synonym: "negative regulation of interleukin-16 synthesis" EXACT []
-is_a: GO:0032699 ! negative regulation of interleukin-16 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process
-relationship: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process
-
-[Term]
-id: GO:0045377
-name: positive regulation of interleukin-16 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
-synonym: "activation of interleukin-16 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-16 biosynthesis" EXACT []
-synonym: "positive regulation of IL-16 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-16 anabolism" EXACT []
-synonym: "positive regulation of interleukin-16 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-16 formation" EXACT []
-synonym: "positive regulation of interleukin-16 synthesis" EXACT []
-synonym: "stimulation of interleukin-16 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-16 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-16 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-16 biosynthetic process" EXACT []
-is_a: GO:0032739 ! positive regulation of interleukin-16 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process
-relationship: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process
-
-[Term]
-id: GO:0045378
-name: regulation of interleukin-17 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]
-synonym: "regulation of IL-17 biosynthesis" EXACT []
-synonym: "regulation of IL-17 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-17 anabolism" EXACT []
-synonym: "regulation of interleukin-17 biosynthesis" EXACT []
-synonym: "regulation of interleukin-17 formation" EXACT []
-synonym: "regulation of interleukin-17 synthesis" EXACT []
-is_a: GO:0032660 ! regulation of interleukin-17 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042235 ! interleukin-17 biosynthetic process
-relationship: regulates GO:0042235 ! interleukin-17 biosynthetic process
-
-[Term]
-id: GO:0045379
-name: negative regulation of interleukin-17 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]
-synonym: "down regulation of interleukin-17 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-17 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-17 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-17 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-17 biosynthesis" EXACT []
-synonym: "negative regulation of IL-17 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-17 anabolism" EXACT []
-synonym: "negative regulation of interleukin-17 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-17 formation" EXACT []
-synonym: "negative regulation of interleukin-17 synthesis" EXACT []
-is_a: GO:0032700 ! negative regulation of interleukin-17 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process
-relationship: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process
-
-[Term]
-id: GO:0045380
-name: positive regulation of interleukin-17 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]
-synonym: "activation of interleukin-17 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-17 biosynthesis" EXACT []
-synonym: "positive regulation of IL-17 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-17 anabolism" EXACT []
-synonym: "positive regulation of interleukin-17 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-17 formation" EXACT []
-synonym: "positive regulation of interleukin-17 synthesis" EXACT []
-synonym: "stimulation of interleukin-17 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-17 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-17 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-17 biosynthetic process" EXACT []
-is_a: GO:0032740 ! positive regulation of interleukin-17 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process
-relationship: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process
-
-[Term]
-id: GO:0045381
-name: regulation of interleukin-18 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
-synonym: "regulation of IL-18 biosynthesis" EXACT []
-synonym: "regulation of IL-18 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-18 anabolism" EXACT []
-synonym: "regulation of interleukin-18 biosynthesis" EXACT []
-synonym: "regulation of interleukin-18 formation" EXACT []
-synonym: "regulation of interleukin-18 synthesis" EXACT []
-is_a: GO:0032661 ! regulation of interleukin-18 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042241 ! interleukin-18 biosynthetic process
-relationship: regulates GO:0042241 ! interleukin-18 biosynthetic process
-
-[Term]
-id: GO:0045382
-name: negative regulation of interleukin-18 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
-synonym: "down regulation of interleukin-18 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-18 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-18 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-18 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-18 biosynthesis" EXACT []
-synonym: "negative regulation of IL-18 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-18 anabolism" EXACT []
-synonym: "negative regulation of interleukin-18 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-18 formation" EXACT []
-synonym: "negative regulation of interleukin-18 synthesis" EXACT []
-is_a: GO:0032701 ! negative regulation of interleukin-18 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process
-relationship: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process
-
-[Term]
-id: GO:0045383
-name: positive regulation of interleukin-18 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
-synonym: "activation of interleukin-18 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-18 biosynthesis" EXACT []
-synonym: "positive regulation of IL-18 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-18 anabolism" EXACT []
-synonym: "positive regulation of interleukin-18 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-18 formation" EXACT []
-synonym: "positive regulation of interleukin-18 synthesis" EXACT []
-synonym: "stimulation of interleukin-18 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-18 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-18 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-18 biosynthetic process" EXACT []
-is_a: GO:0032741 ! positive regulation of interleukin-18 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process
-relationship: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process
-
-[Term]
-id: GO:0045384
-name: regulation of interleukin-19 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
-synonym: "regulation of IL-19 biosynthesis" EXACT []
-synonym: "regulation of IL-19 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-19 anabolism" EXACT []
-synonym: "regulation of interleukin-19 biosynthesis" EXACT []
-synonym: "regulation of interleukin-19 formation" EXACT []
-synonym: "regulation of interleukin-19 synthesis" EXACT []
-is_a: GO:0032662 ! regulation of interleukin-19 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042236 ! interleukin-19 biosynthetic process
-relationship: regulates GO:0042236 ! interleukin-19 biosynthetic process
-
-[Term]
-id: GO:0045385
-name: negative regulation of interleukin-19 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
-synonym: "down regulation of interleukin-19 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-19 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-19 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-19 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-19 biosynthesis" EXACT []
-synonym: "negative regulation of IL-19 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-19 anabolism" EXACT []
-synonym: "negative regulation of interleukin-19 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-19 formation" EXACT []
-synonym: "negative regulation of interleukin-19 synthesis" EXACT []
-is_a: GO:0032702 ! negative regulation of interleukin-19 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process
-relationship: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process
-
-[Term]
-id: GO:0045386
-name: positive regulation of interleukin-19 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
-synonym: "activation of interleukin-19 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-19 biosynthesis" EXACT []
-synonym: "positive regulation of IL-19 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-19 anabolism" EXACT []
-synonym: "positive regulation of interleukin-19 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-19 formation" EXACT []
-synonym: "positive regulation of interleukin-19 synthesis" EXACT []
-synonym: "stimulation of interleukin-19 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-19 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-19 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-19 biosynthetic process" EXACT []
-is_a: GO:0032742 ! positive regulation of interleukin-19 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process
-relationship: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process
-
-[Term]
-id: GO:0045387
-name: regulation of interleukin-20 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
-synonym: "regulation of IL-20 biosynthesis" EXACT []
-synonym: "regulation of IL-20 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-20 anabolism" EXACT []
-synonym: "regulation of interleukin-20 biosynthesis" EXACT []
-synonym: "regulation of interleukin-20 formation" EXACT []
-synonym: "regulation of interleukin-20 synthesis" EXACT []
-is_a: GO:0032664 ! regulation of interleukin-20 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042237 ! interleukin-20 biosynthetic process
-relationship: regulates GO:0042237 ! interleukin-20 biosynthetic process
-
-[Term]
-id: GO:0045388
-name: negative regulation of interleukin-20 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
-synonym: "down regulation of interleukin-20 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-20 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-20 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-20 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-20 biosynthesis" EXACT []
-synonym: "negative regulation of IL-20 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-20 anabolism" EXACT []
-synonym: "negative regulation of interleukin-20 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-20 formation" EXACT []
-synonym: "negative regulation of interleukin-20 synthesis" EXACT []
-is_a: GO:0032704 ! negative regulation of interleukin-20 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process
-relationship: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process
-
-[Term]
-id: GO:0045389
-name: positive regulation of interleukin-20 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
-synonym: "activation of interleukin-20 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-20 biosynthesis" EXACT []
-synonym: "positive regulation of IL-20 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-20 anabolism" EXACT []
-synonym: "positive regulation of interleukin-20 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-20 formation" EXACT []
-synonym: "positive regulation of interleukin-20 synthesis" EXACT []
-synonym: "stimulation of interleukin-20 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-20 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-20 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-20 biosynthetic process" EXACT []
-is_a: GO:0032744 ! positive regulation of interleukin-20 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process
-relationship: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process
-
-[Term]
-id: GO:0045390
-name: regulation of interleukin-21 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
-synonym: "regulation of IL-21 biosynthesis" EXACT []
-synonym: "regulation of IL-21 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-21 anabolism" EXACT []
-synonym: "regulation of interleukin-21 biosynthesis" EXACT []
-synonym: "regulation of interleukin-21 formation" EXACT []
-synonym: "regulation of interleukin-21 synthesis" EXACT []
-is_a: GO:0032665 ! regulation of interleukin-21 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042238 ! interleukin-21 biosynthetic process
-relationship: regulates GO:0042238 ! interleukin-21 biosynthetic process
-
-[Term]
-id: GO:0045391
-name: negative regulation of interleukin-21 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
-synonym: "down regulation of interleukin-21 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-21 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-21 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-21 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-21 biosynthesis" EXACT []
-synonym: "negative regulation of IL-21 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-21 anabolism" EXACT []
-synonym: "negative regulation of interleukin-21 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-21 formation" EXACT []
-synonym: "negative regulation of interleukin-21 synthesis" EXACT []
-is_a: GO:0032705 ! negative regulation of interleukin-21 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process
-relationship: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process
-
-[Term]
-id: GO:0045392
-name: positive regulation of interleukin-21 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
-synonym: "activation of interleukin-21 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-21 biosynthesis" EXACT []
-synonym: "positive regulation of IL-21 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-21 anabolism" EXACT []
-synonym: "positive regulation of interleukin-21 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-21 formation" EXACT []
-synonym: "positive regulation of interleukin-21 synthesis" EXACT []
-synonym: "stimulation of interleukin-21 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-21 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-21 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-21 biosynthetic process" EXACT []
-is_a: GO:0032745 ! positive regulation of interleukin-21 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process
-relationship: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process
-
-[Term]
-id: GO:0045393
-name: regulation of interleukin-22 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
-synonym: "regulation of IL-22 biosynthesis" EXACT []
-synonym: "regulation of IL-22 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-22 anabolism" EXACT []
-synonym: "regulation of interleukin-22 biosynthesis" EXACT []
-synonym: "regulation of interleukin-22 formation" EXACT []
-synonym: "regulation of interleukin-22 synthesis" EXACT []
-is_a: GO:0032666 ! regulation of interleukin-22 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042239 ! interleukin-22 biosynthetic process
-relationship: regulates GO:0042239 ! interleukin-22 biosynthetic process
-
-[Term]
-id: GO:0045394
-name: negative regulation of interleukin-22 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
-synonym: "down regulation of interleukin-22 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-22 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-22 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-22 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-22 biosynthesis" EXACT []
-synonym: "negative regulation of IL-22 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-22 anabolism" EXACT []
-synonym: "negative regulation of interleukin-22 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-22 formation" EXACT []
-synonym: "negative regulation of interleukin-22 synthesis" EXACT []
-is_a: GO:0032706 ! negative regulation of interleukin-22 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process
-relationship: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process
-
-[Term]
-id: GO:0045395
-name: positive regulation of interleukin-22 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
-synonym: "activation of interleukin-22 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-22 biosynthesis" EXACT []
-synonym: "positive regulation of IL-22 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-22 anabolism" EXACT []
-synonym: "positive regulation of interleukin-22 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-22 formation" EXACT []
-synonym: "positive regulation of interleukin-22 synthesis" EXACT []
-synonym: "stimulation of interleukin-22 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-22 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-22 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-22 biosynthetic process" EXACT []
-is_a: GO:0032746 ! positive regulation of interleukin-22 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process
-relationship: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process
-
-[Term]
-id: GO:0045396
-name: regulation of interleukin-23 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
-synonym: "regulation of IL-23 biosynthesis" EXACT []
-synonym: "regulation of IL-23 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-23 anabolism" EXACT []
-synonym: "regulation of interleukin-23 biosynthesis" EXACT []
-synonym: "regulation of interleukin-23 formation" EXACT []
-synonym: "regulation of interleukin-23 synthesis" EXACT []
-is_a: GO:0032667 ! regulation of interleukin-23 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042240 ! interleukin-23 biosynthetic process
-relationship: regulates GO:0042240 ! interleukin-23 biosynthetic process
-
-[Term]
-id: GO:0045397
-name: negative regulation of interleukin-23 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
-synonym: "down regulation of interleukin-23 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-23 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-23 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-23 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-23 biosynthesis" EXACT []
-synonym: "negative regulation of IL-23 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-23 anabolism" EXACT []
-synonym: "negative regulation of interleukin-23 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-23 formation" EXACT []
-synonym: "negative regulation of interleukin-23 synthesis" EXACT []
-is_a: GO:0032707 ! negative regulation of interleukin-23 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process
-relationship: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process
-
-[Term]
-id: GO:0045398
-name: positive regulation of interleukin-23 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
-synonym: "activation of interleukin-23 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-23 biosynthesis" EXACT []
-synonym: "positive regulation of IL-23 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-23 anabolism" EXACT []
-synonym: "positive regulation of interleukin-23 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-23 formation" EXACT []
-synonym: "positive regulation of interleukin-23 synthesis" EXACT []
-synonym: "stimulation of interleukin-23 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-23 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-23 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-23 biosynthetic process" EXACT []
-is_a: GO:0032747 ! positive regulation of interleukin-23 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process
-relationship: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process
-
-[Term]
-id: GO:0045399
-name: regulation of interleukin-3 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
-synonym: "regulation of IL-3 biosynthesis" EXACT []
-synonym: "regulation of IL-3 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-3 anabolism" EXACT []
-synonym: "regulation of interleukin-3 biosynthesis" EXACT []
-synonym: "regulation of interleukin-3 formation" EXACT []
-synonym: "regulation of interleukin-3 synthesis" EXACT []
-is_a: GO:0032672 ! regulation of interleukin-3 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042223 ! interleukin-3 biosynthetic process
-relationship: regulates GO:0042223 ! interleukin-3 biosynthetic process
-
-[Term]
-id: GO:0045400
-name: negative regulation of interleukin-3 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
-synonym: "down regulation of interleukin-3 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-3 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-3 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-3 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-3 biosynthesis" EXACT []
-synonym: "negative regulation of IL-3 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-3 anabolism" EXACT []
-synonym: "negative regulation of interleukin-3 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-3 formation" EXACT []
-synonym: "negative regulation of interleukin-3 synthesis" EXACT []
-is_a: GO:0032712 ! negative regulation of interleukin-3 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process
-relationship: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process
-
-[Term]
-id: GO:0045401
-name: positive regulation of interleukin-3 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
-synonym: "activation of interleukin-3 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-3 biosynthesis" EXACT []
-synonym: "positive regulation of IL-3 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-3 anabolism" EXACT []
-synonym: "positive regulation of interleukin-3 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-3 formation" EXACT []
-synonym: "positive regulation of interleukin-3 synthesis" EXACT []
-synonym: "stimulation of interleukin-3 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-3 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-3 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-3 biosynthetic process" EXACT []
-is_a: GO:0032752 ! positive regulation of interleukin-3 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process
-relationship: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process
-
-[Term]
-id: GO:0045402
-name: regulation of interleukin-4 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
-synonym: "regulation of IL-4 biosynthesis" EXACT []
-synonym: "regulation of IL-4 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-4 anabolism" EXACT []
-synonym: "regulation of interleukin-4 biosynthesis" EXACT []
-synonym: "regulation of interleukin-4 formation" EXACT []
-synonym: "regulation of interleukin-4 synthesis" EXACT []
-is_a: GO:0032673 ! regulation of interleukin-4 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042097 ! interleukin-4 biosynthetic process
-relationship: regulates GO:0042097 ! interleukin-4 biosynthetic process
-
-[Term]
-id: GO:0045403
-name: negative regulation of interleukin-4 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
-synonym: "down regulation of interleukin-4 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-4 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-4 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-4 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-4 biosynthesis" EXACT []
-synonym: "negative regulation of IL-4 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-4 anabolism" EXACT []
-synonym: "negative regulation of interleukin-4 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-4 formation" EXACT []
-synonym: "negative regulation of interleukin-4 synthesis" EXACT []
-is_a: GO:0032713 ! negative regulation of interleukin-4 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process
-relationship: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process
-
-[Term]
-id: GO:0045404
-name: positive regulation of interleukin-4 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
-synonym: "activation of interleukin-4 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-4 biosynthesis" EXACT []
-synonym: "positive regulation of IL-4 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-4 anabolism" EXACT []
-synonym: "positive regulation of interleukin-4 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-4 formation" EXACT []
-synonym: "positive regulation of interleukin-4 synthesis" EXACT []
-synonym: "stimulation of interleukin-4 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-4 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-4 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-4 biosynthetic process" EXACT []
-is_a: GO:0032753 ! positive regulation of interleukin-4 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process
-relationship: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process
-
-[Term]
-id: GO:0045405
-name: regulation of interleukin-5 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
-synonym: "regulation of IL-5 biosynthesis" EXACT []
-synonym: "regulation of IL-5 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-5 anabolism" EXACT []
-synonym: "regulation of interleukin-5 biosynthesis" EXACT []
-synonym: "regulation of interleukin-5 formation" EXACT []
-synonym: "regulation of interleukin-5 synthesis" EXACT []
-is_a: GO:0032674 ! regulation of interleukin-5 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042225 ! interleukin-5 biosynthetic process
-relationship: regulates GO:0042225 ! interleukin-5 biosynthetic process
-
-[Term]
-id: GO:0045406
-name: negative regulation of interleukin-5 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
-synonym: "down regulation of interleukin-5 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-5 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-5 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-5 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-5 biosynthesis" EXACT []
-synonym: "negative regulation of IL-5 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-5 anabolism" EXACT []
-synonym: "negative regulation of interleukin-5 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-5 formation" EXACT []
-synonym: "negative regulation of interleukin-5 synthesis" EXACT []
-is_a: GO:0032714 ! negative regulation of interleukin-5 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process
-relationship: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process
-
-[Term]
-id: GO:0045407
-name: positive regulation of interleukin-5 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
-synonym: "activation of interleukin-5 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-5 biosynthesis" EXACT []
-synonym: "positive regulation of IL-5 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-5 anabolism" EXACT []
-synonym: "positive regulation of interleukin-5 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-5 formation" EXACT []
-synonym: "positive regulation of interleukin-5 synthesis" EXACT []
-synonym: "stimulation of interleukin-5 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-5 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-5 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-5 biosynthetic process" EXACT []
-is_a: GO:0032754 ! positive regulation of interleukin-5 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process
-relationship: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process
-
-[Term]
-id: GO:0045408
-name: regulation of interleukin-6 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
-synonym: "regulation of IL-6 biosynthesis" EXACT []
-synonym: "regulation of IL-6 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-6 anabolism" EXACT []
-synonym: "regulation of interleukin-6 biosynthesis" EXACT []
-synonym: "regulation of interleukin-6 formation" EXACT []
-synonym: "regulation of interleukin-6 synthesis" EXACT []
-is_a: GO:0032675 ! regulation of interleukin-6 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042226 ! interleukin-6 biosynthetic process
-relationship: regulates GO:0042226 ! interleukin-6 biosynthetic process
-
-[Term]
-id: GO:0045409
-name: negative regulation of interleukin-6 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
-synonym: "down regulation of interleukin-6 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-6 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-6 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-6 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-6 biosynthesis" EXACT []
-synonym: "negative regulation of IL-6 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-6 anabolism" EXACT []
-synonym: "negative regulation of interleukin-6 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-6 formation" EXACT []
-synonym: "negative regulation of interleukin-6 synthesis" EXACT []
-is_a: GO:0032715 ! negative regulation of interleukin-6 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process
-relationship: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process
-
-[Term]
-id: GO:0045410
-name: positive regulation of interleukin-6 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
-synonym: "activation of interleukin-6 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-6 biosynthesis" EXACT []
-synonym: "positive regulation of IL-6 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-6 anabolism" EXACT []
-synonym: "positive regulation of interleukin-6 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-6 formation" EXACT []
-synonym: "positive regulation of interleukin-6 synthesis" EXACT []
-synonym: "stimulation of interleukin-6 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-6 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-6 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-6 biosynthetic process" EXACT []
-is_a: GO:0032755 ! positive regulation of interleukin-6 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process
-relationship: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process
-
-[Term]
-id: GO:0045411
-name: regulation of interleukin-7 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
-synonym: "regulation of IL-7 biosynthesis" EXACT []
-synonym: "regulation of IL-7 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-7 anabolism" EXACT []
-synonym: "regulation of interleukin-7 biosynthesis" EXACT []
-synonym: "regulation of interleukin-7 formation" EXACT []
-synonym: "regulation of interleukin-7 synthesis" EXACT []
-is_a: GO:0032676 ! regulation of interleukin-7 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042227 ! interleukin-7 biosynthetic process
-relationship: regulates GO:0042227 ! interleukin-7 biosynthetic process
-
-[Term]
-id: GO:0045412
-name: negative regulation of interleukin-7 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
-synonym: "down regulation of interleukin-7 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-7 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-7 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-7 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-7 biosynthesis" EXACT []
-synonym: "negative regulation of IL-7 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-7 anabolism" EXACT []
-synonym: "negative regulation of interleukin-7 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-7 formation" EXACT []
-synonym: "negative regulation of interleukin-7 synthesis" EXACT []
-is_a: GO:0032716 ! negative regulation of interleukin-7 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process
-relationship: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process
-
-[Term]
-id: GO:0045413
-name: positive regulation of interleukin-7 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
-synonym: "activation of interleukin-7 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-7 biosynthesis" EXACT []
-synonym: "positive regulation of IL-7 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-7 anabolism" EXACT []
-synonym: "positive regulation of interleukin-7 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-7 formation" EXACT []
-synonym: "positive regulation of interleukin-7 synthesis" EXACT []
-synonym: "stimulation of interleukin-7 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-7 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-7 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-7 biosynthetic process" EXACT []
-is_a: GO:0032756 ! positive regulation of interleukin-7 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process
-relationship: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process
-
-[Term]
-id: GO:0045414
-name: regulation of interleukin-8 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
-synonym: "regulation of IL-8 biosynthesis" EXACT []
-synonym: "regulation of IL-8 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-8 anabolism" EXACT []
-synonym: "regulation of interleukin-8 biosynthesis" EXACT []
-synonym: "regulation of interleukin-8 formation" EXACT []
-synonym: "regulation of interleukin-8 synthesis" EXACT []
-is_a: GO:0032677 ! regulation of interleukin-8 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042228 ! interleukin-8 biosynthetic process
-relationship: regulates GO:0042228 ! interleukin-8 biosynthetic process
-
-[Term]
-id: GO:0045415
-name: negative regulation of interleukin-8 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
-synonym: "down regulation of interleukin-8 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-8 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-8 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-8 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-8 biosynthesis" EXACT []
-synonym: "negative regulation of IL-8 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-8 anabolism" EXACT []
-synonym: "negative regulation of interleukin-8 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-8 formation" EXACT []
-synonym: "negative regulation of interleukin-8 synthesis" EXACT []
-is_a: GO:0032717 ! negative regulation of interleukin-8 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process
-relationship: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process
-
-[Term]
-id: GO:0045416
-name: positive regulation of interleukin-8 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
-synonym: "activation of interleukin-8 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-8 biosynthesis" EXACT []
-synonym: "positive regulation of IL-8 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-8 anabolism" EXACT []
-synonym: "positive regulation of interleukin-8 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-8 formation" EXACT []
-synonym: "positive regulation of interleukin-8 synthesis" EXACT []
-synonym: "stimulation of interleukin-8 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-8 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-8 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-8 biosynthetic process" EXACT []
-is_a: GO:0032757 ! positive regulation of interleukin-8 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process
-relationship: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process
-
-[Term]
-id: GO:0045417
-name: regulation of interleukin-9 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
-synonym: "regulation of IL-9 biosynthesis" EXACT []
-synonym: "regulation of IL-9 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-9 anabolism" EXACT []
-synonym: "regulation of interleukin-9 biosynthesis" EXACT []
-synonym: "regulation of interleukin-9 formation" EXACT []
-synonym: "regulation of interleukin-9 synthesis" EXACT []
-is_a: GO:0032678 ! regulation of interleukin-9 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0042229 ! interleukin-9 biosynthetic process
-relationship: regulates GO:0042229 ! interleukin-9 biosynthetic process
-
-[Term]
-id: GO:0045418
-name: negative regulation of interleukin-9 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
-synonym: "down regulation of interleukin-9 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-9 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-9 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-9 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-9 biosynthesis" EXACT []
-synonym: "negative regulation of IL-9 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-9 anabolism" EXACT []
-synonym: "negative regulation of interleukin-9 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-9 formation" EXACT []
-synonym: "negative regulation of interleukin-9 synthesis" EXACT []
-is_a: GO:0032718 ! negative regulation of interleukin-9 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process
-relationship: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process
-
-[Term]
-id: GO:0045419
-name: positive regulation of interleukin-9 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
-synonym: "activation of interleukin-9 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-9 biosynthesis" EXACT []
-synonym: "positive regulation of IL-9 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-9 anabolism" EXACT []
-synonym: "positive regulation of interleukin-9 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-9 formation" EXACT []
-synonym: "positive regulation of interleukin-9 synthesis" EXACT []
-synonym: "stimulation of interleukin-9 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-9 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-9 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-9 biosynthetic process" EXACT []
-is_a: GO:0032758 ! positive regulation of interleukin-9 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process
-relationship: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process
-
-[Term]
-id: GO:0045420
-name: regulation of connective tissue growth factor biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators]
-synonym: "regulation of connective tissue growth factor anabolism" EXACT []
-synonym: "regulation of connective tissue growth factor biosynthesis" EXACT []
-synonym: "regulation of connective tissue growth factor formation" EXACT []
-synonym: "regulation of connective tissue growth factor synthesis" EXACT []
-is_a: GO:0032643 ! regulation of connective tissue growth factor production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0045189 ! connective tissue growth factor biosynthetic process
-relationship: regulates GO:0045189 ! connective tissue growth factor biosynthetic process
-
-[Term]
-id: GO:0045421
-name: negative regulation of connective tissue growth factor biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators]
-synonym: "down regulation of connective tissue growth factor biosynthetic process" EXACT []
-synonym: "down-regulation of connective tissue growth factor biosynthetic process" EXACT []
-synonym: "downregulation of connective tissue growth factor biosynthetic process" EXACT []
-synonym: "inhibition of connective tissue growth factor biosynthetic process" NARROW []
-synonym: "negative regulation of connective tissue growth factor anabolism" EXACT []
-synonym: "negative regulation of connective tissue growth factor biosynthesis" EXACT []
-synonym: "negative regulation of connective tissue growth factor formation" EXACT []
-synonym: "negative regulation of connective tissue growth factor synthesis" EXACT []
-is_a: GO:0032683 ! negative regulation of connective tissue growth factor production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process
-relationship: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process
-
-[Term]
-id: GO:0045422
-name: positive regulation of connective tissue growth factor biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators]
-synonym: "activation of connective tissue growth factor biosynthetic process" NARROW []
-synonym: "positive regulation of connective tissue growth factor anabolism" EXACT []
-synonym: "positive regulation of connective tissue growth factor biosynthesis" EXACT []
-synonym: "positive regulation of connective tissue growth factor formation" EXACT []
-synonym: "positive regulation of connective tissue growth factor synthesis" EXACT []
-synonym: "stimulation of connective tissue growth factor biosynthetic process" NARROW []
-synonym: "up regulation of connective tissue growth factor biosynthetic process" EXACT []
-synonym: "up-regulation of connective tissue growth factor biosynthetic process" EXACT []
-synonym: "upregulation of connective tissue growth factor biosynthetic process" EXACT []
-is_a: GO:0032723 ! positive regulation of connective tissue growth factor production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process
-relationship: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process
-
[Term]
id: GO:0045423
name: regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
@@ -270232,7 +268644,6 @@ synonym: "regulation of nitric oxide anabolism" EXACT []
synonym: "regulation of nitric oxide biosynthesis" EXACT []
synonym: "regulation of nitric oxide formation" EXACT []
synonym: "regulation of nitric oxide synthesis" EXACT []
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process
@@ -270327,6 +268738,7 @@ def: "Catalysis of the cyclization of beta rings at one or both ends of the lyco
synonym: "crtL" RELATED []
synonym: "lycopene cyclase" BROAD []
xref: MetaCyc:RXN1F-150
+xref: RHEA:32219
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity
@@ -270530,7 +268942,7 @@ namespace: biological_process
def: "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [PMID:10618248]
synonym: "sterigmatocystin metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0043385 ! mycotoxin metabolic process
+is_a: GO:0009404 ! toxin metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
[Term]
@@ -270542,8 +268954,8 @@ synonym: "sterigmatocystin anabolism" EXACT []
synonym: "sterigmatocystin biosynthesis" EXACT []
synonym: "sterigmatocystin formation" EXACT []
synonym: "sterigmatocystin synthesis" EXACT []
+is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
-is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0045460 ! sterigmatocystin metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process
@@ -270629,9 +269041,6 @@ name: response to ethanol
namespace: biological_process
alt_id: GO:0017036
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]
-is_a: GO:0009636 ! response to toxic substance
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:0097305 ! response to alcohol
[Term]
@@ -270819,6 +269228,7 @@ synonym: "naringenin 3-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.9]
xref: EC:1.14.11.9
xref: MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN
+xref: RHEA:18621
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
[Term]
@@ -270833,7 +269243,6 @@ synonym: "gibberellic acid degradation" NARROW []
synonym: "gibberellin catabolism" EXACT []
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0016103 ! diterpenoid catabolic process
-is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
[Term]
@@ -270843,7 +269252,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge." [GOC:tair_curators]
synonym: "pectin metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process
-is_a: GO:0017144 ! drug metabolic process
[Term]
id: GO:0045489
@@ -270866,7 +269274,6 @@ synonym: "pectin breakdown" EXACT []
synonym: "pectin catabolism" EXACT []
synonym: "pectin degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0045488 ! pectin metabolic process
[Term]
@@ -271158,312 +269565,6 @@ synonym: "IL-27" NARROW []
synonym: "interleukin-27 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
-[Term]
-id: GO:0045524
-name: interleukin-24 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
-synonym: "IL-24 biosynthesis" EXACT []
-synonym: "IL-24 biosynthetic process" EXACT []
-synonym: "interleukin-24 anabolism" EXACT []
-synonym: "interleukin-24 biosynthesis" EXACT []
-synonym: "interleukin-24 formation" EXACT []
-synonym: "interleukin-24 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032628 ! interleukin-24 production
-
-[Term]
-id: GO:0045525
-name: interleukin-25 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
-synonym: "IL-25 biosynthesis" EXACT []
-synonym: "IL-25 biosynthetic process" EXACT []
-synonym: "interleukin-25 anabolism" EXACT []
-synonym: "interleukin-25 biosynthesis" EXACT []
-synonym: "interleukin-25 formation" EXACT []
-synonym: "interleukin-25 synthesis" EXACT []
-is_a: GO:0042235 ! interleukin-17 biosynthetic process
-relationship: part_of GO:0032629 ! interleukin-25 production
-
-[Term]
-id: GO:0045526
-name: interleukin-26 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
-synonym: "IL-26 biosynthesis" EXACT []
-synonym: "IL-26 biosynthetic process" EXACT []
-synonym: "interleukin-26 anabolism" EXACT []
-synonym: "interleukin-26 biosynthesis" EXACT []
-synonym: "interleukin-26 formation" EXACT []
-synonym: "interleukin-26 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032630 ! interleukin-26 production
-
-[Term]
-id: GO:0045527
-name: interleukin-27 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
-synonym: "IL-27 biosynthesis" EXACT []
-synonym: "IL-27 biosynthetic process" EXACT []
-synonym: "interleukin-27 anabolism" EXACT []
-synonym: "interleukin-27 biosynthesis" EXACT []
-synonym: "interleukin-27 formation" EXACT []
-synonym: "interleukin-27 synthesis" EXACT []
-is_a: GO:0042089 ! cytokine biosynthetic process
-relationship: part_of GO:0032631 ! interleukin-27 production
-
-[Term]
-id: GO:0045528
-name: regulation of interleukin-24 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
-synonym: "regulation of IL-24 biosynthesis" EXACT []
-synonym: "regulation of IL-24 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-24 anabolism" EXACT []
-synonym: "regulation of interleukin-24 biosynthesis" EXACT []
-synonym: "regulation of interleukin-24 formation" EXACT []
-synonym: "regulation of interleukin-24 synthesis" EXACT []
-is_a: GO:0032668 ! regulation of interleukin-24 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0045524 ! interleukin-24 biosynthetic process
-relationship: regulates GO:0045524 ! interleukin-24 biosynthetic process
-
-[Term]
-id: GO:0045529
-name: regulation of interleukin-25 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
-synonym: "regulation of IL-25 biosynthesis" EXACT []
-synonym: "regulation of IL-25 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-25 anabolism" EXACT []
-synonym: "regulation of interleukin-25 biosynthesis" EXACT []
-synonym: "regulation of interleukin-25 formation" EXACT []
-synonym: "regulation of interleukin-25 synthesis" EXACT []
-is_a: GO:0032669 ! regulation of interleukin-25 production
-is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0045525 ! interleukin-25 biosynthetic process
-relationship: regulates GO:0045525 ! interleukin-25 biosynthetic process
-
-[Term]
-id: GO:0045530
-name: regulation of interleukin-26 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
-synonym: "regulation of IL-26 biosynthesis" EXACT []
-synonym: "regulation of IL-26 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-26 anabolism" EXACT []
-synonym: "regulation of interleukin-26 biosynthesis" EXACT []
-synonym: "regulation of interleukin-26 formation" EXACT []
-synonym: "regulation of interleukin-26 synthesis" EXACT []
-is_a: GO:0032670 ! regulation of interleukin-26 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0045526 ! interleukin-26 biosynthetic process
-relationship: regulates GO:0045526 ! interleukin-26 biosynthetic process
-
-[Term]
-id: GO:0045531
-name: regulation of interleukin-27 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
-synonym: "regulation of IL-27 biosynthesis" EXACT []
-synonym: "regulation of IL-27 biosynthetic process" EXACT []
-synonym: "regulation of interleukin-27 anabolism" EXACT []
-synonym: "regulation of interleukin-27 biosynthesis" EXACT []
-synonym: "regulation of interleukin-27 formation" EXACT []
-synonym: "regulation of interleukin-27 synthesis" EXACT []
-is_a: GO:0032671 ! regulation of interleukin-27 production
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0045527 ! interleukin-27 biosynthetic process
-relationship: regulates GO:0045527 ! interleukin-27 biosynthetic process
-
-[Term]
-id: GO:0045532
-name: negative regulation of interleukin-24 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
-synonym: "down regulation of interleukin-24 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-24 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-24 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-24 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-24 biosynthesis" EXACT []
-synonym: "negative regulation of IL-24 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-24 anabolism" EXACT []
-synonym: "negative regulation of interleukin-24 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-24 formation" EXACT []
-synonym: "negative regulation of interleukin-24 synthesis" EXACT []
-is_a: GO:0032708 ! negative regulation of interleukin-24 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process
-relationship: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process
-
-[Term]
-id: GO:0045533
-name: negative regulation of interleukin-25 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
-synonym: "down regulation of interleukin-25 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-25 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-25 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-25 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-25 biosynthesis" EXACT []
-synonym: "negative regulation of IL-25 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-25 anabolism" EXACT []
-synonym: "negative regulation of interleukin-25 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-25 formation" EXACT []
-synonym: "negative regulation of interleukin-25 synthesis" EXACT []
-is_a: GO:0032709 ! negative regulation of interleukin-25 production
-is_a: GO:0045379 ! negative regulation of interleukin-17 biosynthetic process
-is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process
-relationship: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process
-
-[Term]
-id: GO:0045534
-name: negative regulation of interleukin-26 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
-synonym: "down regulation of interleukin-26 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-26 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-26 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-26 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-26 biosynthesis" EXACT []
-synonym: "negative regulation of IL-26 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-26 anabolism" EXACT []
-synonym: "negative regulation of interleukin-26 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-26 formation" EXACT []
-synonym: "negative regulation of interleukin-26 synthesis" EXACT []
-is_a: GO:0032710 ! negative regulation of interleukin-26 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process
-relationship: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process
-
-[Term]
-id: GO:0045535
-name: negative regulation of interleukin-27 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
-synonym: "down regulation of interleukin-27 biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-27 biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-27 biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-27 biosynthetic process" NARROW []
-synonym: "negative regulation of IL-27 biosynthesis" EXACT []
-synonym: "negative regulation of IL-27 biosynthetic process" EXACT []
-synonym: "negative regulation of interleukin-27 anabolism" EXACT []
-synonym: "negative regulation of interleukin-27 biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-27 formation" EXACT []
-synonym: "negative regulation of interleukin-27 synthesis" EXACT []
-is_a: GO:0032711 ! negative regulation of interleukin-27 production
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process
-relationship: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process
-
-[Term]
-id: GO:0045536
-name: positive regulation of interleukin-24 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
-synonym: "activation of interleukin-24 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-24 biosynthesis" EXACT []
-synonym: "positive regulation of IL-24 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-24 anabolism" EXACT []
-synonym: "positive regulation of interleukin-24 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-24 formation" EXACT []
-synonym: "positive regulation of interleukin-24 synthesis" EXACT []
-synonym: "stimulation of interleukin-24 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-24 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-24 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-24 biosynthetic process" EXACT []
-is_a: GO:0032748 ! positive regulation of interleukin-24 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process
-relationship: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process
-
-[Term]
-id: GO:0045537
-name: positive regulation of interleukin-25 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
-synonym: "activation of interleukin-25 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-25 biosynthesis" EXACT []
-synonym: "positive regulation of IL-25 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-25 anabolism" EXACT []
-synonym: "positive regulation of interleukin-25 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-25 formation" EXACT []
-synonym: "positive regulation of interleukin-25 synthesis" EXACT []
-synonym: "stimulation of interleukin-25 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-25 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-25 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-25 biosynthetic process" EXACT []
-is_a: GO:0032749 ! positive regulation of interleukin-25 production
-is_a: GO:0045380 ! positive regulation of interleukin-17 biosynthetic process
-is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process
-relationship: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process
-
-[Term]
-id: GO:0045538
-name: positive regulation of interleukin-26 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
-synonym: "activation of interleukin-26 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-26 biosynthesis" EXACT []
-synonym: "positive regulation of IL-26 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-26 anabolism" EXACT []
-synonym: "positive regulation of interleukin-26 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-26 formation" EXACT []
-synonym: "positive regulation of interleukin-26 synthesis" EXACT []
-synonym: "stimulation of interleukin-26 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-26 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-26 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-26 biosynthetic process" EXACT []
-is_a: GO:0032750 ! positive regulation of interleukin-26 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process
-relationship: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process
-
-[Term]
-id: GO:0045539
-name: positive regulation of interleukin-27 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
-synonym: "activation of interleukin-27 biosynthetic process" NARROW []
-synonym: "positive regulation of IL-27 biosynthesis" EXACT []
-synonym: "positive regulation of IL-27 biosynthetic process" EXACT []
-synonym: "positive regulation of interleukin-27 anabolism" EXACT []
-synonym: "positive regulation of interleukin-27 biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-27 formation" EXACT []
-synonym: "positive regulation of interleukin-27 synthesis" EXACT []
-synonym: "stimulation of interleukin-27 biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-27 biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-27 biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-27 biosynthetic process" EXACT []
-is_a: GO:0032751 ! positive regulation of interleukin-27 production
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process
-relationship: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process
-
[Term]
id: GO:0045540
name: regulation of cholesterol biosynthetic process
@@ -271957,8 +270058,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of sterigma
synonym: "sterigmatocystin breakdown" EXACT []
synonym: "sterigmatocystin catabolism" EXACT []
synonym: "sterigmatocystin degradation" EXACT []
+is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
-is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0045460 ! sterigmatocystin metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
@@ -274412,7 +272513,6 @@ synonym: "acetate catabolism" EXACT []
synonym: "acetate degradation" EXACT []
synonym: "homoacetate catabolic process" RELATED []
is_a: GO:0006083 ! acetate metabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
[Term]
@@ -278836,6 +276936,7 @@ synonym: "PDAT activity" EXACT [EC:2.3.1.158]
synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.158]
xref: EC:2.3.1.158
xref: MetaCyc:2.3.1.158-RXN
+xref: RHEA:14057
is_a: GO:0008080 ! N-acetyltransferase activity
[Term]
@@ -278901,7 +277002,6 @@ synonym: "adenylate forming enzyme activity" RELATED []
synonym: "AMP metabolism" EXACT []
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process
-is_a: GO:0017144 ! drug metabolic process
[Term]
id: GO:0046034
@@ -279446,7 +277546,6 @@ name: adenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
synonym: "adenosine metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process
[Term]
@@ -280045,7 +278144,6 @@ synonym: "coenzyme and prosthetic group biosynthetic process" EXACT []
synonym: "coenzyme and prosthetic group formation" EXACT []
synonym: "coenzyme and prosthetic group synthesis" EXACT []
is_obsolete: true
-consider: GO:0009108
consider: GO:0051191
[Term]
@@ -280059,7 +278157,6 @@ synonym: "coenzyme and prosthetic group catabolic process" EXACT []
synonym: "coenzyme and prosthetic group catabolism" EXACT []
synonym: "coenzyme and prosthetic group degradation" EXACT []
is_obsolete: true
-consider: GO:0009109
consider: GO:0051190
[Term]
@@ -280073,7 +278170,6 @@ synonym: "corrin formation" EXACT []
synonym: "corrin synthesis" EXACT []
is_a: GO:0015009 ! corrin metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
[Term]
id: GO:0046141
@@ -280085,7 +278181,6 @@ synonym: "corrin catabolism" EXACT []
synonym: "corrin degradation" EXACT []
is_a: GO:0015009 ! corrin metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process
-is_a: GO:0051187 ! cofactor catabolic process
[Term]
id: GO:0046142
@@ -280095,7 +278190,6 @@ def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true
-consider: GO:0051198
consider: GO:0051201
[Term]
@@ -280106,7 +278200,6 @@ def: "OBSOLETE. Any process that activates or increases the frequency, rate or e
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" EXACT []
is_obsolete: true
-consider: GO:0051197
consider: GO:0051200
[Term]
@@ -280136,8 +278229,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [PMID:21871890]
synonym: "5,6,7,8-tetrahydrobiopterin metabolic process" EXACT [GOC:curators]
synonym: "tetrahydrobiopterin metabolism" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0042558 ! pteridine-containing compound metabolic process
@@ -280150,10 +278241,8 @@ synonym: "5,6,7,8-tetrahydrobiopterin catabolic process" EXACT [Wikipedia:Tetrah
synonym: "tetrahydrobiopterin breakdown" EXACT []
synonym: "tetrahydrobiopterin catabolism" EXACT []
synonym: "tetrahydrobiopterin degradation" EXACT []
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0042560 ! pteridine-containing compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046146 ! tetrahydrobiopterin metabolic process
[Term]
@@ -280778,7 +278867,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of cresol,
synonym: "cresol breakdown" EXACT []
synonym: "cresol catabolism" EXACT []
synonym: "cresol degradation" EXACT []
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042212 ! cresol metabolic process
@@ -280883,7 +278971,6 @@ synonym: "spermine catabolism" EXACT []
synonym: "spermine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0008215 ! spermine metabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0046209
@@ -280891,8 +278978,6 @@ name: nitric oxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
synonym: "nitric oxide metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
-is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0072593 ! reactive oxygen species metabolic process
is_a: GO:2001057 ! reactive nitrogen species metabolic process
@@ -280904,8 +278989,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of nitric o
synonym: "nitric oxide breakdown" EXACT []
synonym: "nitric oxide catabolism" EXACT []
synonym: "nitric oxide degradation" EXACT []
-is_a: GO:0042135 ! neurotransmitter catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046209 ! nitric oxide metabolic process
@@ -280958,8 +279041,9 @@ synonym: "enterobactin catabolism" EXACT []
synonym: "enterobactin degradation" EXACT []
is_a: GO:0009238 ! enterobactin metabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
+is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0046215 ! siderophore catabolic process
-is_a: GO:0046700 ! heterocycle catabolic process
+is_a: GO:1901335 ! lactone catabolic process
[Term]
id: GO:0046215
@@ -280971,7 +279055,6 @@ synonym: "siderophore breakdown" EXACT []
synonym: "siderophore catabolism" EXACT []
synonym: "siderophore degradation" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
-is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
[Term]
@@ -281132,10 +279215,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of 2,4,5-tr
synonym: "2,4,5-trichlorophenoxyacetic acid breakdown" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid catabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid degradation" EXACT []
-is_a: GO:0009852 ! auxin catabolic process
is_a: GO:0018980 ! 2,4,5-trichlorophenoxyacetic acid metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
-is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process
@@ -281256,7 +279337,6 @@ synonym: "mandelate anabolism" EXACT []
synonym: "mandelate biosynthesis" EXACT []
synonym: "mandelate formation" EXACT []
synonym: "mandelate synthesis" EXACT []
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018924 ! mandelate metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
@@ -281376,10 +279456,7 @@ synonym: "salicylic acid breakdown" EXACT []
synonym: "salicylic acid catabolism" EXACT []
synonym: "salicylic acid degradation" EXACT []
is_a: GO:0009696 ! salicylic acid metabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
-is_a: GO:0042447 ! hormone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
[Term]
@@ -281817,7 +279894,6 @@ def: "The chemical reactions and pathways involving protocatechuate, the anion o
synonym: "protocatechuate metabolic process" EXACT [PMID:25072253]
synonym: "protocatechuate metabolism" EXACT []
is_a: GO:0009712 ! catechol-containing compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
@@ -281905,7 +279981,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732]
synonym: "flavonoid phytoalexin metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
-is_a: GO:0052314 ! phytoalexin metabolic process
[Term]
id: GO:0046286
@@ -281988,7 +280063,6 @@ synonym: "formaldehyde metabolism" EXACT []
synonym: "methanal metabolic process" EXACT []
synonym: "methanal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0044281 ! small molecule metabolic process
[Term]
@@ -282002,7 +280076,6 @@ synonym: "formaldehyde formation" EXACT []
synonym: "formaldehyde synthesis" EXACT []
synonym: "methanal biosynthesis" EXACT []
synonym: "methanal biosynthetic process" EXACT []
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0046292 ! formaldehyde metabolic process
@@ -282017,7 +280090,6 @@ synonym: "formaldehyde catabolism" EXACT []
synonym: "formaldehyde degradation" EXACT []
synonym: "methanal catabolic process" EXACT []
synonym: "methanal catabolism" EXACT []
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046292 ! formaldehyde metabolic process
@@ -282046,7 +280118,6 @@ synonym: "glycolate catabolism" EXACT []
synonym: "glycolate degradation" EXACT []
is_a: GO:0009441 ! glycolate metabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
[Term]
@@ -282098,10 +280169,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dich
synonym: "2,4-dichlorophenoxyacetic acid breakdown" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid catabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid degradation" EXACT []
-is_a: GO:0009852 ! auxin catabolic process
is_a: GO:0018901 ! 2,4-dichlorophenoxyacetic acid metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
-is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process
@@ -282130,7 +280199,6 @@ synonym: "2-chloro-N-isopropylacetanilide catabolism" EXACT []
synonym: "2-chloro-N-isopropylacetanilide degradation" EXACT []
is_a: GO:0018889 ! 2-chloro-N-isopropylacetanilide metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
-is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
@@ -282628,7 +280696,6 @@ name: CDP-diacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis." [PMID:24533860]
synonym: "CDP-diacylglycerol metabolism" EXACT []
-is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0006650 ! glycerophospholipid metabolic process
[Term]
@@ -282639,7 +280706,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of CDP-diac
synonym: "CDP-diacylglycerol breakdown" EXACT []
synonym: "CDP-diacylglycerol catabolism" EXACT []
synonym: "CDP-diacylglycerol degradation" EXACT []
-is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0046341 ! CDP-diacylglycerol metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process
@@ -282818,7 +280884,6 @@ synonym: "acetyl-CoA breakdown" EXACT []
synonym: "acetyl-CoA catabolism" EXACT []
synonym: "acetyl-CoA degradation" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
@@ -283093,9 +281158,10 @@ synonym: "N-acetylneuraminate biosynthesis" EXACT []
synonym: "N-acetylneuraminate formation" EXACT []
synonym: "N-acetylneuraminate synthesis" EXACT []
is_a: GO:0006054 ! N-acetylneuraminate metabolic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
+is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0046349 ! amino sugar biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
+is_a: GO:1901566 ! organonitrogen compound biosynthetic process
[Term]
id: GO:0046381
@@ -283325,6 +281391,7 @@ synonym: "polynucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.32]
xref: EC:3.1.3.32
xref: MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN
xref: Reactome:R-HSA-5649705 "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)"
+xref: RHEA:14113
is_a: GO:0098518 ! polynucleotide phosphatase activity
relationship: part_of GO:0098506 ! polynucleotide 3' dephosphorylation
@@ -283340,6 +281407,7 @@ synonym: "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity
xref: EC:2.7.1.78
xref: KEGG_REACTION:R03840
xref: MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN
+xref: RHEA:15669
is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity
is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity
@@ -283606,6 +281674,7 @@ def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophos
synonym: "1,4-Dihydroxy-2-naphtoate prenyltransferase activity" EXACT []
xref: EC:2.5.1
xref: MetaCyc:DMK-RXN
+xref: RHEA:30099
is_a: GO:0002094 ! polyprenyltransferase activity
[Term]
@@ -283620,6 +281689,7 @@ synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" EXACT [M
xref: EC:1.17.7.1
xref: KEGG_REACTION:R08689
xref: MetaCyc:RXN0-882
+xref: RHEA:26119
is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
[Term]
@@ -283645,7 +281715,6 @@ name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai]
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
[Term]
@@ -283728,7 +281797,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "L-lysine metabolism" EXACT []
is_a: GO:0006553 ! lysine metabolic process
-is_a: GO:0017144 ! drug metabolic process
[Term]
id: GO:0046441
@@ -283746,7 +281814,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai]
synonym: "aerobactin metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
-is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
[Term]
@@ -283767,7 +281834,6 @@ name: FMN metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, PMID:20822113]
synonym: "FMN metabolism" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process
@@ -284040,7 +282106,7 @@ synonym: "PAF metabolic process" EXACT []
synonym: "PAF metabolism" EXACT []
synonym: "platelet activating factor metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
-is_a: GO:0017144 ! drug metabolic process
+is_a: GO:0046485 ! ether lipid metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
[Term]
@@ -284344,7 +282410,6 @@ synonym: "S-adenosylhomocysteine metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
[Term]
@@ -284365,9 +282430,7 @@ synonym: "S-adenosyl methionine metabolic process" EXACT []
synonym: "S-adenosyl methionine metabolism" EXACT []
synonym: "S-adenosylmethionine metabolism" EXACT []
synonym: "SAM metabolic process" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0071704 ! organic substance metabolic process
[Term]
@@ -284492,6 +282555,7 @@ def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfo
synonym: "sulfolipid synthase" BROAD []
synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT []
xref: MetaCyc:RXN-1224
+xref: RHEA:49468
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -284689,6 +282753,7 @@ xref: EC:2.4.1.133
xref: MetaCyc:2.4.1.133-RXN
xref: Reactome:R-HSA-1889981 "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker"
xref: Reactome:R-HSA-3560804 "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker"
+xref: RHEA:15297
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein
@@ -285082,6 +283147,7 @@ synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" EXACT [EC:3.2.1.1
synonym: "alpha-glucosiduronase activity" EXACT [EC:3.2.1.139]
xref: EC:3.2.1.139
xref: MetaCyc:3.2.1.139-RXN
+xref: RHEA:20005
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -285096,8 +283162,6 @@ synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32]
synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32]
synonym: "scytalidopepsin B activity" EXACT []
synonym: "SLB" RELATED [EC:3.4.23.32]
-xref: EC:3.4.23.32
-xref: MetaCyc:3.4.23.32-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -285122,8 +283186,6 @@ synonym: "Penicillium janthinellum aspartic proteinase activity" EXACT [EC:3.4.2
synonym: "Penicillium roqueforti acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "penicillopepsin activity" EXACT []
synonym: "peptidase A activity" BROAD [EC:3.4.23.20]
-xref: EC:3.4.23.20
-xref: MetaCyc:3.4.23.20-RXN
is_obsolete: true
replaced_by: GO:0004190
@@ -285303,6 +283365,7 @@ synonym: "long-chain fatty alcohol oxidase activity" EXACT []
synonym: "long-chain-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20]
xref: EC:1.1.3.20
xref: MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN
+xref: RHEA:22756
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
[Term]
@@ -285369,7 +283432,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732]
synonym: "enniatin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
-is_a: GO:0043385 ! mycotoxin metabolic process
is_a: GO:0050761 ! depsipeptide metabolic process
is_a: GO:1901334 ! lactone metabolic process
@@ -285383,7 +283445,6 @@ synonym: "enniatin biosynthesis" EXACT []
synonym: "enniatin formation" EXACT []
synonym: "enniatin synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
-is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046584 ! enniatin metabolic process
is_a: GO:0050763 ! depsipeptide biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
@@ -286278,7 +284339,6 @@ synonym: "vitamin M metabolic process" EXACT []
synonym: "vitamin M metabolism" EXACT []
is_a: GO:0006760 ! folic acid-containing compound metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
[Term]
@@ -286319,7 +284379,6 @@ synonym: "vitamin M catabolic process" EXACT []
synonym: "vitamin M catabolism" EXACT []
is_a: GO:0009397 ! folic acid-containing compound catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
is_a: GO:0046655 ! folic acid metabolic process
@@ -286556,8 +284615,7 @@ name: response to streptomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:curators]
synonym: "streptomycin susceptibility/resistance" RELATED []
-is_a: GO:0042493 ! response to drug
-is_a: GO:0060992 ! response to fungicide
+is_a: GO:0046677 ! response to antibiotic
is_a: GO:1903416 ! response to glycoside
[Term]
@@ -286569,7 +284627,6 @@ synonym: "DDT resistance" RELATED []
synonym: "DDT susceptibility/resistance" RELATED []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0017085 ! response to insecticide
-is_a: GO:0042493 ! response to drug
[Term]
id: GO:0046681
@@ -286891,7 +284948,6 @@ namespace: biological_process
def: "The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [PMID:21710975]
synonym: "boron transport" RELATED []
is_a: GO:0015698 ! inorganic anion transport
-is_a: GO:0015893 ! drug transport
[Term]
id: GO:0046714
@@ -286899,7 +284955,6 @@ name: borate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with borate, the anion (BO3)3-." [GOC:curators]
synonym: "boron binding" RELATED []
-is_a: GO:0008144 ! drug binding
is_a: GO:0043168 ! anion binding
[Term]
@@ -288379,7 +286434,6 @@ name: quinolinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]
synonym: "quinolinate metabolism" EXACT []
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
@@ -288694,8 +286748,6 @@ def: "Any process that results in a change in state or activity of a cell or an
synonym: "response to actidione" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
-is_a: GO:0060992 ! response to fungicide
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
@@ -289053,28 +287105,35 @@ is_a: GO:0065003 ! protein-containing complex assembly
id: GO:0046932
name: sodium-transporting ATP synthase activity, rotational mechanism
namespace: molecular_function
-def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism." [EC:7.2.2.1, RHEA:58158, TC:3.A.2.1.2]
+def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism." [RHEA:58158]
synonym: "sodium-translocating F-type ATPase activity" EXACT []
synonym: "sodium-transporting two-sector ATPase activity" EXACT []
xref: EC:7.2.2.1
xref: MetaCyc:3.6.3.15-RXN
xref: RHEA:58158
+xref: TC:3.A.2.1.2
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
+is_a: GO:0016874 ! ligase activity
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19380 xsd:anyURI
[Term]
id: GO:0046933
name: proton-transporting ATP synthase activity, rotational mechanism
namespace: molecular_function
-def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:7.1.2.2, TC:3.A.2.1.1]
+def: "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out)." [RHEA:57722]
synonym: "H+-transporting ATP synthase activity" EXACT [EC:7.1.2.2]
synonym: "hydrogen ion translocating F-type ATPase activity" EXACT []
synonym: "hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT []
synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT []
+xref: EC:7.1.2.2
xref: MetaCyc:ATPSYN-RXN
xref: Reactome:R-HSA-164832 "ATPase synthesizes ATP"
xref: RHEA:57722
+xref: TC:3.A.2.1.1
is_a: GO:0015252 ! proton channel activity
-is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
+is_a: GO:0016874 ! ligase activity
+relationship: part_of GO:0015986 ! ATP synthesis coupled proton transport
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19380 xsd:anyURI
[Term]
id: GO:0046934
@@ -289128,6 +287187,11 @@ xref: Reactome:R-HSA-8852019 "MET bound PI3K generates PIP3"
xref: Reactome:R-HSA-8853323 "Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-9021627 "EPOR-associated PI3K phosphorylates PIP2 to PIP3"
xref: Reactome:R-HSA-9603445 "Activated NTRK3 stimulates PI3K activity"
+xref: Reactome:R-HSA-9664664 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3"
+xref: Reactome:R-HSA-9664940 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3"
+xref: Reactome:R-HSA-9665407 "PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3"
+xref: Reactome:R-HSA-9672162 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers"
+xref: Reactome:R-HSA-9672177 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR"
xref: RHEA:21292
is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity
is_a: GO:0052813 ! phosphatidylinositol bisphosphate kinase activity
@@ -289150,6 +287214,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: deoxyadenosine + H2O = deoxyinosine + NH3." [EC:3.5.4.4, GOC:ai]
synonym: "deoxyadenosine deaminase reaction" EXACT []
xref: MetaCyc:ADDALT-RXN
+xref: RHEA:28190
is_a: GO:0019239 ! deaminase activity
[Term]
@@ -289322,7 +287387,7 @@ synonym: "ketone body degradation" EXACT []
synonym: "utilization of ketone bodies" EXACT [Reactome:R-HSA-77108]
xref: MetaCyc:PWY66-368
xref: Reactome:R-HSA-77108
-is_a: GO:0042737 ! drug catabolic process
+is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046950 ! cellular ketone body metabolic process
is_a: GO:1901569 ! fatty acid derivative catabolic process
@@ -289380,28 +287445,25 @@ is_a: GO:0046958 ! nonassociative learning
id: GO:0046961
name: proton-transporting ATPase activity, rotational mechanism
namespace: molecular_function
-def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
-synonym: "ATP phosphohydrolase (H+-transporting) activity" EXACT [EC:3.6.3.14]
-synonym: "ATP synthase activity" BROAD [EC:3.6.3.14]
-synonym: "bacterial Ca2+/Mg2+ ATPase" NARROW [EC:3.6.3.14]
-synonym: "chloroplast ATPase activity" NARROW [EC:3.6.3.14]
-synonym: "coupling factors (Fo, F1 and CF1)" RELATED [EC:3.6.3.14]
-synonym: "F(0)F(1)-ATPase activity" NARROW [EC:3.6.3.14]
-synonym: "F(1)-ATPase activity" NARROW [EC:3.6.3.14]
-synonym: "F(o)F(1)-ATPase activity" NARROW [EC:3.6.3.14]
-synonym: "F0F1-ATPase" NARROW [EC:3.6.3.14]
-synonym: "F1-ATPase" NARROW [EC:3.6.3.14]
-synonym: "FoF1-ATPase" NARROW [EC:3.6.3.14]
-synonym: "H(+)-transporting ATP synthase activity" EXACT [EC:3.6.3.14]
-synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.14]
-synonym: "H+-transporting ATPase activity" EXACT [EC:3.6.3.14]
-synonym: "H+-transporting two-sector ATPase" NARROW [EC:3.6.3.14]
+def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]
+synonym: "ATP phosphohydrolase (H+-transporting) activity" RELATED []
+synonym: "ATP synthase activity" BROAD [EC:7.1.2.2]
+synonym: "chloroplast ATPase activity" NARROW [EC:7.1.2.2]
+synonym: "F(0)F(1)-ATPase activity" NARROW [EC:7.1.2.2]
+synonym: "F(1)-ATPase activity" NARROW [EC:7.1.2.2]
+synonym: "F(o)F(1)-ATPase activity" NARROW [EC:7.1.2.2]
+synonym: "F0F1-ATPase" NARROW [EC:7.1.2.2]
+synonym: "F1-ATPase" NARROW []
+synonym: "FoF1-ATPase" NARROW [EC:7.1.2.2]
+synonym: "H(+)-transporting ATP synthase activity" RELATED [EC:7.1.2.2]
+synonym: "H+-transporting ATPase activity" RELATED [EC:7.1.2.2]
synonym: "hydrogen ion translocating A-type ATPase activity" NARROW []
synonym: "hydrogen ion translocating F-type ATPase activity" NARROW []
synonym: "hydrogen ion translocating V-type ATPase activity" NARROW []
synonym: "hydrogen ion transporting ATPase activity, rotational mechanism" EXACT []
synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW []
-synonym: "mitochondrial ATPase activity" NARROW [EC:3.6.3.14]
+synonym: "mitochondrial ATPase activity" NARROW [EC:7.1.2.2]
+xref: EC:7.1.2.2
xref: MetaCyc:ATPSYN-RXN
xref: RHEA:57721
is_a: GO:0009678 ! pyrophosphate hydrolysis-driven proton transmembrane transporter activity
@@ -289412,7 +287474,7 @@ is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, r
id: GO:0046962
name: sodium-transporting ATPase activity, rotational mechanism
namespace: molecular_function
-def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) => ADP + phosphate + Na+(out), by a rotational mechanism." [EC:7.2.2.1, RHEA:58157]
+def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) => ADP + phosphate + Na+(out), by a rotational mechanism." [RHEA:58157]
synonym: "ATP phosphohydrolase (Na+-transporting) activity" RELATED []
synonym: "ATP synthase, sodium ion specific activity" EXACT [EC:7.2.2.1]
synonym: "Na(+)-translocating ATPase activity" BROAD []
@@ -289715,6 +287777,7 @@ synonym: "arylhydroxamate N,O-acetyltransferase activity" EXACT [EC:2.3.1.118]
synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" EXACT [EC:2.3.1.118]
xref: EC:2.3.1.118
xref: MetaCyc:2.3.1.118-RXN
+xref: RHEA:20277
is_a: GO:0016413 ! O-acetyltransferase activity
[Term]
@@ -290145,6 +288208,7 @@ synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" EXACT [EC
synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201]
xref: EC:1.1.1.201
xref: MetaCyc:1.1.1.201-RXN
+xref: RHEA:20233
xref: Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -290191,6 +288255,7 @@ synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleot
synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.1.1.212]
xref: EC:1.1.1.212
xref: MetaCyc:1.1.1.212-RXN
+xref: RHEA:19913
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -290571,6 +288636,7 @@ def: "Catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocy
synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" EXACT [EC:1.1.2.5]
xref: EC:1.1.2.5
xref: MetaCyc:1.1.2.5-RXN
+xref: RHEA:16465
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
[Term]
@@ -290677,6 +288743,7 @@ synonym: "PVA dehydrogenase activity" BROAD [EC:1.1.99.23]
xref: EC:1.1.2.6
xref: KEGG_REACTION:R03136
xref: MetaCyc:RXN-11316
+xref: RHEA:20157
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
[Term]
@@ -290728,6 +288795,7 @@ synonym: "ascorbate-cytochrome b5 reductase activity" EXACT [EC:1.10.2.1]
synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.10.2.1]
xref: EC:1.10.2.1
xref: MetaCyc:1.10.2.1-RXN
+xref: RHEA:18677
is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
[Term]
@@ -290773,6 +288841,7 @@ xref: Reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE"
xref: Reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE"
xref: Reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA"
xref: Reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA"
+xref: RHEA:19057
is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor
[Term]
@@ -290840,6 +288909,7 @@ synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizi
synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.16]
xref: EC:1.13.11.16
xref: MetaCyc:1.13.11.16-RXN
+xref: RHEA:23840
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
[Term]
@@ -290891,6 +288961,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." [EC:1.13.11.-, MetaCyc:R308-RXN]
xref: EC:1.13.11
xref: MetaCyc:RXN-10137
+xref: RHEA:35595
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
[Term]
@@ -291133,7 +289204,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0047092
name: 27-hydroxycholesterol 7-alpha-monooxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [EC:1.14.14.29, MetaCyc:1.14.13.60-RXN, RHEA:24308]
+def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [RHEA:24308]
synonym: "27-hydroxycholesterol 7-alpha-hydroxylase activity" EXACT [EC:1.14.14.29]
synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT []
synonym: "27-hydroxycholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.14.29]
@@ -291274,6 +289345,7 @@ synonym: "2-oxoisovalerate dehydrogenase activity" EXACT [EC:1.2.1.25]
synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" EXACT [EC:1.2.1.25]
xref: EC:1.2.1.25
xref: MetaCyc:1.2.1.25-RXN
+xref: RHEA:13997
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -291444,6 +289516,7 @@ synonym: "aldehyde dehydrogenase (pyrroloquinoline-quinone)" RELATED []
synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" EXACT [EC:1.2.99.3]
xref: EC:1.2.5.2
xref: MetaCyc:1.2.99.3-RXN
+xref: RHEA:13881
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors
[Term]
@@ -291712,6 +289785,7 @@ def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine.
synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.12]
xref: EC:1.5.3.12
xref: MetaCyc:1.5.3.12-RXN
+xref: RHEA:16621
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
[Term]
@@ -291723,6 +289797,7 @@ synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activi
synonym: "DMADh activity" RELATED [EC:1.5.8.1]
xref: EC:1.5.8.1
xref: MetaCyc:1.5.8.1-RXN
+xref: RHEA:10204
xref: UM-BBD_reactionID:r1380
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor
@@ -291886,7 +289961,7 @@ is_a: GO:0016491 ! oxidoreductase activity
id: GO:0047144
name: 2-acylglycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [EC:2.3.1.52, GOC:ab, MetaCyc:2-ACYL2.3.1.15-RXN, RHEA:14233]
+def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [GOC:ab, RHEA:14233]
synonym: "2-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.52]
synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.52]
xref: EC:2.3.1.52
@@ -291897,6 +289972,7 @@ xref: Reactome:R-HSA-1482626 "2-acyl LPI is acylated to PI by MBOAT7"
xref: Reactome:R-HSA-1482635 "2-acyl LPG is acylated to PG by LPGAT"
xref: Reactome:R-HSA-1482646 "2-acyl LPE is acylated to PE by LPEAT"
xref: Reactome:R-HSA-1482691 "2-acyl LPS is acylated to PS by LPSAT"
+xref: RHEA:14233
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity
@@ -291998,6 +290074,7 @@ synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxi
xref: EC:2.1.1.74
xref: KEGG_REACTION:R03704
xref: MetaCyc:2.1.1.74-RXN
+xref: RHEA:16873
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -292097,6 +290174,7 @@ synonym: "myelin PLP acyltransferase activity" EXACT [EC:2.3.1.100]
synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100]
xref: EC:2.3.1.100
xref: MetaCyc:2.3.1.100-RXN
+xref: RHEA:14869
is_a: GO:0016416 ! O-palmitoyltransferase activity
[Term]
@@ -292235,6 +290313,7 @@ synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" EXACT [EC:2.3.1
synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.125]
xref: EC:2.3.1.125
xref: MetaCyc:2.3.1.125-RXN
+xref: RHEA:21996
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -292308,6 +290387,7 @@ synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acylt
xref: EC:2.3.1.135
xref: MetaCyc:2.3.1.135-RXN
xref: Reactome:R-HSA-975608 "LRAT esterifies RBP2:atROL and FACYLs to atREs"
+xref: RHEA:17469
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -292338,6 +290418,7 @@ synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransf
synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.141]
xref: EC:2.3.1.141
xref: MetaCyc:2.3.1.141-RXN
+xref: RHEA:17057
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -292364,6 +290445,7 @@ synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-
synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147]
xref: EC:2.3.1.147
xref: MetaCyc:2.3.1.147-RXN
+xref: RHEA:15409
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -292374,6 +290456,7 @@ def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine
synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" EXACT [EC:2.3.1.148]
xref: EC:2.3.1.148
xref: MetaCyc:2.3.1.148-RXN
+xref: RHEA:20972
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -292385,6 +290468,7 @@ synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero
synonym: "PAF acetyltransferase activity" EXACT []
xref: EC:2.3.1.149
xref: MetaCyc:2.3.1.149-RXN
+xref: RHEA:11048
is_a: GO:0016407 ! acetyltransferase activity
[Term]
@@ -292429,6 +290513,7 @@ def: "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoy
synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.153]
xref: EC:2.3.1.153
xref: MetaCyc:RXN-7945
+xref: RHEA:15661
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -292480,6 +290565,7 @@ synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" EXACT [EC:2
synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45]
xref: EC:2.3.1.45
xref: MetaCyc:2.3.1.45-RXN
+xref: RHEA:20808
is_a: GO:0016413 ! O-acetyltransferase activity
[Term]
@@ -292493,6 +290579,7 @@ synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase
synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" EXACT [EC:2.3.1.49]
xref: EC:2.3.1.49
xref: MetaCyc:2.3.1.49-RXN
+xref: RHEA:20393
is_a: GO:0016418 ! S-acetyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -292552,6 +290639,7 @@ def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA
synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.63]
xref: EC:2.3.1.63
xref: MetaCyc:2.3.1.63-RXN
+xref: RHEA:23992
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -292575,6 +290663,7 @@ synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67]
synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67]
xref: EC:2.3.1.67
xref: MetaCyc:2.3.1.67-RXN
+xref: RHEA:18461
is_a: GO:0016413 ! O-acetyltransferase activity
[Term]
@@ -292614,6 +290703,7 @@ synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" EXACT [EC:2.3
synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" EXACT [EC:2.3.1.73]
xref: EC:2.3.1.73
xref: MetaCyc:2.3.1.73-RXN
+xref: RHEA:13301
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -292644,6 +290734,7 @@ synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" EXACT
synonym: "triacylglycerol:sterol acyltransferase activity" EXACT [EC:2.3.1.77]
xref: EC:2.3.1.77
xref: MetaCyc:2.3.1.77-RXN
+xref: RHEA:16897
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -292859,6 +290950,7 @@ synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" EXACT [EC:2.4.1
synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115]
xref: EC:2.4.1.115
xref: MetaCyc:2.4.1.115-RXN
+xref: RHEA:20093
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -292872,6 +290964,7 @@ synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltra
synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116]
xref: EC:2.4.1.116
xref: MetaCyc:2.4.1.116-RXN
+xref: RHEA:12144
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -292971,6 +291064,7 @@ xref: EC:2.4.1.134
xref: MetaCyc:2.4.1.134-RXN
xref: Reactome:R-HSA-1889978 "B3GALT6 transfers Gal to the tetrasaccharide linker"
xref: Reactome:R-HSA-4420365 "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker"
+xref: RHEA:11780
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein
@@ -293020,7 +291114,6 @@ xref: EC:2.4.1.146
xref: MetaCyc:2.4.1.146-RXN
xref: Reactome:R-HSA-5617037 "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1"
xref: Reactome:R-HSA-5617096 "Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1"
-xref: RHEA:12227
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein
@@ -293215,6 +291308,7 @@ synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminylt
synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" EXACT [EC:2.4.1.174]
xref: EC:2.4.1.174
xref: MetaCyc:2.4.1.174-RXN
+xref: RHEA:23464
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity
[Term]
@@ -293463,6 +291557,7 @@ synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucos
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201]
xref: EC:2.4.1.201
xref: MetaCyc:2.4.1.201-RXN
+xref: RHEA:19945
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein
@@ -293521,6 +291616,7 @@ synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" EXACT
synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208]
xref: EC:2.4.1.208
xref: MetaCyc:2.4.1.208-RXN
+xref: RHEA:19165
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -293597,6 +291693,7 @@ synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturo
synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43]
xref: EC:2.4.1.43
xref: MetaCyc:2.4.1.43-RXN
+xref: RHEA:13573
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -293638,6 +291735,7 @@ synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activi
synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52]
xref: EC:2.4.1.52
xref: MetaCyc:2.4.1.52-RXN
+xref: RHEA:15845
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -293653,6 +291751,7 @@ synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity
synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53]
xref: EC:2.4.1.53
xref: MetaCyc:2.4.1.53-RXN
+xref: RHEA:10068
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -293689,6 +291788,7 @@ synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosam
synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70]
xref: EC:2.4.1.70
xref: MetaCyc:2.4.1.70-RXN
+xref: RHEA:21012
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
[Term]
@@ -293865,7 +291965,7 @@ is_a: GO:0035250 ! UDP-galactosyltransferase activity
id: GO:0047280
name: nicotinamide phosphoribosyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide." [EC:2.4.2.12, RHEA:16149]
+def: "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide." [RHEA:16149]
synonym: "nicotinamide mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.12]
synonym: "nicotinamide mononucleotide synthetase activity" EXACT [EC:2.4.2.12]
synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.12]
@@ -293891,6 +291991,7 @@ synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" EXA
synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20]
xref: EC:2.4.2.20
xref: MetaCyc:2.4.2.20-RXN
+xref: RHEA:10232
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
[Term]
@@ -293926,6 +292027,7 @@ def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolich
synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" EXACT [EC:2.4.2.33]
xref: EC:2.4.2.33
xref: MetaCyc:2.4.2.33-RXN
+xref: RHEA:18361
is_a: GO:0042285 ! xylosyltransferase activity
[Term]
@@ -293951,6 +292053,7 @@ synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.36
xref: MetaCyc:RXN-11372
xref: Reactome:R-HSA-5336421 "DT fragment A ADP-ribosylates target cell EEF"
+xref: RHEA:11820
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
[Term]
@@ -294061,6 +292164,7 @@ synonym: "p-hydroxybenzoic-polyprenyl transferase activity" EXACT [EC:2.5.1.39]
synonym: "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity" EXACT [EC:2.5.1.39]
xref: EC:2.5.1.39
xref: MetaCyc:2.5.1.39-RXN
+xref: RHEA:17709
is_a: GO:0002094 ! polyprenyltransferase activity
[Term]
@@ -294099,6 +292203,7 @@ def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2
synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" EXACT [EC:2.5.1.44]
xref: EC:2.5.1.44
xref: MetaCyc:2.5.1.44-RXN
+xref: RHEA:18645
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
[Term]
@@ -294112,6 +292217,7 @@ synonym: "asparagine-oxo-acid aminotransferase activity" EXACT []
synonym: "L-asparagine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14]
xref: EC:2.6.1.14
xref: MetaCyc:2.6.1.14-RXN
+xref: RHEA:19813
is_a: GO:0008483 ! transaminase activity
[Term]
@@ -294375,6 +292481,7 @@ xref: EC:2.6.1.58
xref: KEGG_REACTION:R00692
xref: MetaCyc:2.6.1.58-RXN
xref: Reactome:R-HSA-893593 "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine"
+xref: RHEA:13053
is_a: GO:0070546 ! L-phenylalanine aminotransferase activity
[Term]
@@ -294387,6 +292494,7 @@ synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT []
synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60]
xref: EC:2.6.1.60
xref: MetaCyc:2.6.1.60-RXN
+xref: RHEA:10900
is_a: GO:0008483 ! transaminase activity
[Term]
@@ -294496,6 +292604,7 @@ synonym: "reductase kinase activity" BROAD [EC:2.7.11.31]
synonym: "STK29" RELATED [EC:2.7.11.31]
xref: EC:2.7.11.31
xref: MetaCyc:2.7.1.109-RXN
+xref: RHEA:23172
is_a: GO:0004672 ! protein kinase activity
[Term]
@@ -294517,6 +292626,7 @@ synonym: "STK2" RELATED [EC:2.7.11.4]
xref: EC:2.7.11.4
xref: MetaCyc:2.7.11.4-RXN
xref: Reactome:R-HSA-5693148 "BCKDK phosphorylates BCKDH"
+xref: RHEA:17301
is_a: GO:0004672 ! protein kinase activity
[Term]
@@ -294589,6 +292699,7 @@ synonym: "acyl-phosphate:D-hexose phosphotransferase activity" EXACT [EC:2.7.1.6
synonym: "hexose phosphate:hexose phosphotransferase activity" EXACT [EC:2.7.1.61]
xref: EC:2.7.1.61
xref: MetaCyc:2.7.1.61-RXN
+xref: RHEA:13077
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
@@ -294617,6 +292728,7 @@ synonym: "polyphosphate-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.6
synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63]
xref: EC:2.7.1.63
xref: MetaCyc:2.7.1.63-RXN
+xref: RHEA:22036
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
@@ -294695,6 +292807,7 @@ synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activ
synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17]
xref: EC:2.7.4.17
xref: MetaCyc:2.7.4.17-RXN
+xref: RHEA:18665
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
[Term]
@@ -294719,6 +292832,7 @@ synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" EXACT
synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20]
xref: EC:2.7.4.20
xref: MetaCyc:2.7.4.20-RXN
+xref: RHEA:19417
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
[Term]
@@ -295019,6 +293133,7 @@ synonym: "teichoic acid glycerol transferase activity" EXACT [EC:2.7.8.12]
synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12]
xref: EC:2.7.8.12
xref: MetaCyc:2.7.8.12-RXN
+xref: RHEA:13565
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
[Term]
@@ -295036,6 +293151,7 @@ synonym: "teichoate synthetase activity" EXACT [EC:2.7.8.14]
synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14]
xref: EC:2.7.8.14
xref: MetaCyc:2.7.8.14-RXN
+xref: RHEA:13353
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
[Term]
@@ -295069,6 +293185,7 @@ synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity"
synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19]
xref: EC:2.7.8.19
xref: MetaCyc:2.7.8.19-RXN
+xref: RHEA:20181
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
[Term]
@@ -295080,6 +293197,7 @@ synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activi
synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.22]
xref: EC:2.7.8.22
xref: MetaCyc:2.7.8.22-RXN
+xref: RHEA:21072
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
[Term]
@@ -295132,6 +293250,7 @@ synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT []
synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" EXACT [EC:2.8.2.19]
xref: EC:2.8.2.19
xref: MetaCyc:2.8.2.19-RXN
+xref: RHEA:13273
is_a: GO:0008146 ! sulfotransferase activity
[Term]
@@ -295220,6 +293339,7 @@ synonym: "hydroxymethylglutarate coenzyme A-transferase activity" EXACT [EC:2.8.
synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" EXACT [EC:2.8.3.13]
xref: EC:2.8.3.13
xref: MetaCyc:2.8.3.13-RXN
+xref: RHEA:12284
is_a: GO:0008410 ! CoA-transferase activity
[Term]
@@ -295276,6 +293396,7 @@ xref: Reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular panc
xref: Reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG"
xref: Reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL"
xref: Reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG"
+xref: RHEA:34019
is_a: GO:0016298 ! lipase activity
is_a: GO:0052689 ! carboxylic ester hydrolase activity
@@ -295326,7 +293447,7 @@ is_a: GO:0052689 ! carboxylic ester hydrolase activity
id: GO:0047376
name: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
namespace: molecular_function
-def: "Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate." [MetaCyc:3.1.1.64-RXN, RHEA:13933]
+def: "Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate." [RHEA:13933]
synonym: "all-trans-retinyl-palmitate acylhydrolase activity" BROAD [EC:3.1.1.64]
synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD [EC:3.1.1.64]
synonym: "retinyl-palmitate palmitohydrolase activity" BROAD [KEGG_REACTION:R02368]
@@ -295416,6 +293537,7 @@ synonym: "lauryl-acyl-carrier protein hydrolase activity" EXACT [EC:3.1.2.21]
synonym: "lauryl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21]
xref: EC:3.1.2.21
xref: MetaCyc:3.1.2.21-RXN
+xref: RHEA:30119
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity
[Term]
@@ -295514,6 +293636,7 @@ synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase ac
xref: EC:2.7.7.89
xref: KEGG_REACTION:R03474
xref: MetaCyc:3.1.4.15-RXN
+xref: RHEA:43716
is_a: GO:0008081 ! phosphoric diester hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -295557,6 +293680,7 @@ synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activit
synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39]
xref: EC:3.1.4.39
xref: MetaCyc:3.1.4.39-RXN
+xref: RHEA:15965
is_a: GO:0008081 ! phosphoric diester hydrolase activity
[Term]
@@ -295665,6 +293789,7 @@ synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity"
synonym: "mannosylphosphodolichol phosphodiesterase activity" EXACT [EC:3.1.4.49]
xref: EC:3.1.4.49
xref: MetaCyc:3.1.4.49-RXN
+xref: RHEA:12989
is_a: GO:0008081 ! phosphoric diester hydrolase activity
[Term]
@@ -295676,6 +293801,7 @@ synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrol
synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.51]
xref: EC:3.1.4.51
xref: MetaCyc:3.1.4.51-RXN
+xref: RHEA:18045
is_a: GO:0008081 ! phosphoric diester hydrolase activity
is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein
@@ -295712,6 +293838,7 @@ synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysin
synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" EXACT [EC:3.2.1.107]
xref: EC:3.2.1.107
xref: MetaCyc:3.2.1.107-RXN
+xref: RHEA:11068
is_a: GO:0015926 ! glucosidase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -295748,6 +293875,7 @@ synonym: "pyrimidine nucleotide N-ribosidase activity" EXACT [EC:3.2.2.10]
synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" EXACT [EC:3.2.2.10]
xref: EC:3.2.2.10
xref: MetaCyc:3.2.2.10-RXN
+xref: RHEA:13425
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
[Term]
@@ -295777,6 +293905,7 @@ synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [E
synonym: "dinitrogenase reductase-activating glycohydrolase activity" EXACT [EC:3.2.2.24]
xref: EC:3.2.2.24
xref: MetaCyc:3.2.2.24-RXN
+xref: RHEA:14493
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
[Term]
@@ -295788,6 +293917,7 @@ synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity"
synonym: "lysoplasmalogenase activity" EXACT [EC:3.3.2.2]
xref: EC:3.3.2.2
xref: MetaCyc:3.3.2.2-RXN
+xref: RHEA:22544
is_a: GO:0016803 ! ether hydrolase activity
[Term]
@@ -295798,6 +293928,7 @@ def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanol
synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" EXACT [EC:3.3.2.5]
xref: EC:3.3.2.5
xref: MetaCyc:3.3.2.5-RXN
+xref: RHEA:16905
is_a: GO:0016803 ! ether hydrolase activity
[Term]
@@ -295831,6 +293962,7 @@ synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT []
synonym: "N-acylethanolamine amidohydrolase activity" EXACT []
xref: EC:3.5.1.60
xref: MetaCyc:3.5.1.60-RXN
+xref: RHEA:17505
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -295887,6 +294019,7 @@ synonym: "aralkyl acylamidase activity" EXACT [EC:3.5.1.76]
synonym: "N-acetylarylalkylamine amidohydrolase activity" EXACT [EC:3.5.1.76]
xref: EC:3.5.1.76
xref: MetaCyc:3.5.1.76-RXN
+xref: RHEA:10352
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -295897,6 +294030,7 @@ def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-
synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.77]
xref: EC:3.5.1.77
xref: MetaCyc:3.5.1.77-RXN
+xref: RHEA:11000
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -295908,6 +294042,7 @@ synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79]
synonym: "phthalyl-amide amidohydrolase activity" EXACT [EC:3.5.1.79]
xref: EC:3.5.1.79
xref: MetaCyc:3.5.1.79-RXN
+xref: RHEA:18297
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -295917,6 +294052,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [EC:3.5.1.25, MetaCyc:3.5.1.80-RXN]
xref: EC:3.5.1.25
xref: MetaCyc:3.5.1.80-RXN
+xref: RHEA:18149
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity
@@ -296056,6 +294192,7 @@ synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" EX
synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT []
xref: EC:3.6.1.44
xref: MetaCyc:3.6.1.44-RXN
+xref: RHEA:15205
is_a: GO:0016462 ! pyrophosphatase activity
[Term]
@@ -296380,7 +294517,7 @@ is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
id: GO:0047451
name: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN, PMID:8910376, RHEA:41844]
+def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [PMID:8910376, RHEA:41844]
synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.59]
synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.59]
synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.59]
@@ -296674,6 +294811,7 @@ synonym: "malto-oligosyltrehalose synthase activity" EXACT [EC:5.4.99.15]
synonym: "maltodextrin alpha-D-glucosyltransferase activity" EXACT [EC:5.4.99.15]
xref: EC:5.4.99.15
xref: MetaCyc:5.4.99.15-RXN
+xref: RHEA:13621
is_a: GO:0016866 ! intramolecular transferase activity
[Term]
@@ -296730,6 +294868,7 @@ synonym: "long-chain-fatty-acid-luciferin-component ligase activity" EXACT []
synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" EXACT [EC:6.2.1.19]
xref: EC:6.2.1.19
xref: MetaCyc:6.2.1.19-RXN
+xref: RHEA:20101
is_a: GO:0016878 ! acid-thiol ligase activity
[Term]
@@ -296932,6 +295071,7 @@ synonym: "PATE activity" EXACT [EC:4.2.2.9]
synonym: "pectate exo-lyase activity" EXACT [EC:4.2.2.9]
xref: EC:4.2.2.9
xref: MetaCyc:4.2.2.9-RXN
+xref: RHEA:57104
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides
[Term]
@@ -297279,6 +295419,7 @@ synonym: "beta-1,3-oligoglucan phosphorylase activity" EXACT [EC:2.4.1.30]
synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" EXACT [EC:2.4.1.30]
xref: EC:2.4.1.30
xref: MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN
+xref: RHEA:16041
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -297308,6 +295449,7 @@ synonym: "xylan synthase activity" EXACT [EC:2.4.2.24]
synonym: "xylan synthetase activity" EXACT [EC:2.4.2.24]
xref: EC:2.4.2.24
xref: MetaCyc:RXN-9104
+xref: RHEA:15289
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
@@ -297390,6 +295532,7 @@ def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroi
synonym: "16-hydroxysteroid 16-epimerase activity" EXACT [EC:5.1.99.2]
xref: EC:5.1.99.2
xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN
+xref: RHEA:15829
is_a: GO:0016854 ! racemase and epimerase activity
[Term]
@@ -297431,6 +295574,7 @@ synonym: "2,3-dihydroxybenzoylserine synthetase activity" EXACT [EC:6.3.2.14]
synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" EXACT [EC:6.3.2.14]
xref: EC:6.3.2.14
xref: MetaCyc:23-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN
+xref: RHEA:30571
is_a: GO:0016881 ! acid-amino acid ligase activity
[Term]
@@ -297523,6 +295667,7 @@ synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3]
synonym: "acetolactate mutase activity" EXACT [EC:5.4.99.3]
xref: EC:5.4.99.3
xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN
+xref: RHEA:16361
is_a: GO:0016866 ! intramolecular transferase activity
[Term]
@@ -297596,6 +295741,7 @@ synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" EXACT [EC:3.2.
synonym: "2-deoxy-alpha-glucosidase activity" EXACT [EC:3.2.1.112]
xref: EC:3.2.1.112
xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN
+xref: RHEA:15317
is_a: GO:0015926 ! glucosidase activity
[Term]
@@ -297657,7 +295803,7 @@ is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors,
id: GO:0047544
name: 2-hydroxybiphenyl 3-monooxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+)." [EC:1.14.13.44, RHEA:11996]
+def: "Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+)." [RHEA:11996]
synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.44]
xref: EC:1.14.13.44
xref: KEGG_REACTION:R03964
@@ -297805,6 +295951,7 @@ synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.
synonym: "KGOR activity" EXACT [EC:1.2.7.3]
xref: EC:1.2.7.3
xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN
+xref: RHEA:17297
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
[Term]
@@ -298030,6 +296177,7 @@ synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC
synonym: "delta4-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.99.6]
xref: EC:1.3.99.6
xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN
+xref: RHEA:24172
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors
[Term]
@@ -298080,6 +296228,7 @@ synonym: "delta1-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "delta1-steroid reductase activity" EXACT [EC:1.3.99.4]
xref: EC:1.3.99.4
xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN
+xref: RHEA:13329
xref: UM-BBD_enzymeID:e0712
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors
@@ -298411,6 +296560,7 @@ synonym: "6-oxotetrahydronicotinate dehydrogenase activity" EXACT [EC:1.3.7.1]
synonym: "HNA reductase activity" EXACT [EC:1.3.7.1]
xref: EC:1.3.7.1
xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN
+xref: RHEA:17225
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
[Term]
@@ -298479,6 +296629,7 @@ synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abe
synonym: "trihexose diphospholipid abequosyltransferase activity" EXACT [EC:2.4.1.60]
xref: EC:2.4.1.60
xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN
+xref: RHEA:34183
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -298698,6 +296849,7 @@ synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phos
synonym: "enoyl coenzyme A reductase activity" EXACT [EC:1.3.1.8]
xref: EC:1.3.1.8
xref: MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN
+xref: RHEA:22460
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -298707,7 +296859,7 @@ namespace: molecular_function
alt_id: GO:0008778
alt_id: GO:0016291
alt_id: GO:0016292
-def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN]
+def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [RHEA:16781]
synonym: "acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.20]
synonym: "acyl coenzyme A thioesterase activity" EXACT [EC:3.1.2.20]
synonym: "acyl-CoA thioesterase activity" EXACT []
@@ -298716,7 +296868,6 @@ synonym: "acyl-CoA thioesterase II activity" NARROW []
synonym: "acyl-CoA thiolesterase activity" EXACT []
synonym: "thioesterase B" RELATED [EC:3.1.2.20]
synonym: "thioesterase II" RELATED [EC:3.1.2.20]
-xref: EC:3.1.2
xref: EC:3.1.2.20
xref: MetaCyc:ACYL-COA-HYDROLASE-RXN
xref: Reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA"
@@ -298755,6 +296906,7 @@ synonym: "palmitoyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "palmitoylcarnitine hydrolase activity" EXACT [EC:3.1.1.28]
xref: EC:3.1.1.28
xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN
+xref: RHEA:17101
is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
@@ -298772,6 +296924,7 @@ synonym: "sn-2-monoacylglycerol kinase activity" EXACT [EC:2.7.1.94]
xref: EC:2.7.1.94
xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN
xref: Reactome:R-HSA-5696074 "AGK:Mg2+ phosphorylates MAG, DAG"
+xref: RHEA:19293
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
@@ -298783,6 +296936,7 @@ def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruva
synonym: "3-acylpyruvate acylhydrolase activity" EXACT [EC:3.7.1.5]
xref: EC:3.7.1.5
xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN
+xref: RHEA:19009
xref: UM-BBD_reactionID:r1401
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
@@ -298880,6 +297034,7 @@ synonym: "ADP:dThd phosphotransferase activity" EXACT [EC:2.7.1.118]
synonym: "ADP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.118]
xref: EC:2.7.1.118
xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN
+xref: RHEA:13413
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
@@ -298986,6 +297141,7 @@ synonym: "L-alanine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "leucine-alanine transaminase activity" EXACT [EC:2.6.1.12]
xref: EC:2.6.1.12
xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN
+xref: RHEA:19953
is_a: GO:0008483 ! transaminase activity
[Term]
@@ -299016,6 +297172,7 @@ synonym: "L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity" EXACT [
synonym: "O-alanylphosphatidylglycerol synthase activity" EXACT [EC:2.3.2.11]
xref: EC:2.3.2.11
xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN
+xref: RHEA:20489
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
[Term]
@@ -299056,6 +297213,7 @@ synonym: "D-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.121]
synonym: "dehydrogenase, D-aldohexose" EXACT [EC:1.1.1.121]
xref: EC:1.1.1.121
xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN
+xref: RHEA:15917
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -299097,6 +297255,7 @@ synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" EXACT [EC
synonym: "mannuronosyl transferase activity" EXACT [EC:2.4.1.33]
xref: EC:2.4.1.33
xref: MetaCyc:ALGINATE-SYNTHASE-RXN
+xref: RHEA:46876
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -299138,6 +297297,7 @@ synonym: "bacterial luciferase activity" EXACT [EC:1.14.14.3]
synonym: "vibrio fischeri luciferase activity" EXACT [EC:1.14.14.3]
xref: EC:1.14.14.3
xref: MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN
+xref: RHEA:17181
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
[Term]
@@ -299250,6 +297410,7 @@ synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-form
synonym: "S-alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4]
xref: EC:4.4.1.4
xref: MetaCyc:ALLIIN-LYASE-RXN
+xref: RHEA:20141
is_a: GO:0016846 ! carbon-sulfur lyase activity
[Term]
@@ -299290,6 +297451,7 @@ synonym: "UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activit
synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.183]
xref: EC:2.4.1.183
xref: MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN
+xref: RHEA:19749
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -299305,6 +297467,7 @@ synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" EXACT [EC:3.1.1.43
xref: EC:3.1.1.43
xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN
xref: Reactome:R-HSA-6784959 "BPHL hydrolyses VACV to ACV"
+xref: RHEA:17241
is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
@@ -299351,6 +297514,7 @@ synonym: "aminobenzoate carboxy-lyase (aniline-forming)" EXACT [EC:4.1.1.24]
synonym: "aminobenzoate carboxy-lyase activity" EXACT [EC:4.1.1.24]
xref: EC:4.1.1.24
xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN
+xref: RHEA:24200
is_a: GO:0016831 ! carboxy-lyase activity
[Term]
@@ -299375,7 +297539,7 @@ is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity
id: GO:0047664
name: aminoimidazolase activity
namespace: molecular_function
-def: "Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH(3)." [EC:3.5.4.8, MetaCyc:AMINOIMIDAZOLASE-RXN, RHEA:22348]
+def: "Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH(3)." [RHEA:22348]
synonym: "4-aminoimidazole aminohydrolase activity" EXACT [EC:3.5.4.8]
synonym: "4-aminoimidazole hydrolase activity" EXACT [EC:3.5.4.8]
xref: EC:3.5.4.8
@@ -299441,6 +297605,7 @@ synonym: "AMP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114]
synonym: "thymidine phosphotransferase activity" EXACT [EC:2.7.1.114]
xref: EC:2.7.1.114
xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN
+xref: RHEA:14913
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
@@ -299472,6 +297637,7 @@ synonym: "sucrose-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4]
synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.4]
xref: EC:2.4.1.4
xref: MetaCyc:AMYLOSUCRASE-RXN
+xref: RHEA:24572
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -299634,6 +297800,7 @@ synonym: "aryl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.91]
synonym: "NADPH-linked benzaldehyde reductase activity" EXACT [EC:1.1.1.91]
xref: EC:1.1.1.91
xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN
+xref: RHEA:17761
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -299647,6 +297814,7 @@ synonym: "aryl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.7]
synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7]
xref: EC:1.1.3.7
xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN
+xref: RHEA:17541
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
[Term]
@@ -299658,6 +297826,7 @@ synonym: "aromatic acid reductase activity" EXACT [EC:1.2.1.30]
synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" EXACT [EC:1.2.1.30]
xref: EC:1.2.1.30
xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN
+xref: RHEA:19229
is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity
[Term]
@@ -299684,6 +297853,7 @@ synonym: "amine sulphotransferase activity" EXACT []
synonym: "arylamine sulfotransferase activity" EXACT []
xref: EC:2.8.2.3
xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN
+xref: RHEA:24136
is_a: GO:0008146 ! sulfotransferase activity
[Term]
@@ -299698,6 +297868,7 @@ synonym: "arylsulphate sulphotransferase activity" EXACT []
synonym: "ASST" RELATED [EC:2.8.2.22]
xref: EC:2.8.2.22
xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN
+xref: RHEA:51072
is_a: GO:0008146 ! sulfotransferase activity
[Term]
@@ -299856,6 +298027,7 @@ synonym: "STK15" RELATED [EC:2.7.11.15]
xref: EC:2.7.11.15
xref: Reactome:R-HSA-8851797 "ADRB2 in ADRB2:GRK complex is phosphorylated"
xref: Reactome:R-HSA-8866268 "ADBRK1,2 phosphorylate AVPR2"
+xref: RHEA:19429
is_a: GO:0004672 ! protein kinase activity
[Term]
@@ -299967,6 +298139,7 @@ synonym: "bile-salt sulphotransferase activity" EXACT []
synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14]
xref: EC:2.8.2.14
xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN
+xref: RHEA:14013
is_a: GO:0008146 ! sulfotransferase activity
[Term]
@@ -300264,6 +298437,7 @@ synonym: "sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.9]
synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.9]
xref: EC:2.4.1.9
xref: MetaCyc:INULOSUCRASE-RXN
+xref: RHEA:15745
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -300583,7 +298757,7 @@ is_a: GO:0016878 ! acid-thiol ligase activity
id: GO:0047748
name: cholestanetetraol 26-dehydrogenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN, RHEA:34631]
+def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [RHEA:34631]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT []
synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT []
synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT []
@@ -300702,6 +298876,7 @@ synonym: "chondroitin 4-sulphotransferase activity" EXACT []
xref: EC:2.8.2.5
xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN
xref: Reactome:R-HSA-1971483 "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13"
+xref: RHEA:16101
is_a: GO:0034481 ! chondroitin sulfotransferase activity
[Term]
@@ -301001,6 +299176,7 @@ synonym: "citrate-(pro-3S)-lyase thiolesterase activity" EXACT [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" EXACT [EC:3.1.2.16]
xref: EC:3.1.2.16
xref: MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN
+xref: RHEA:13657
is_a: GO:0016790 ! thiolester hydrolase activity
[Term]
@@ -301074,6 +299250,7 @@ synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5]
synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" EXACT [EC:1.14.15.5]
xref: EC:1.14.15.5
xref: MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN
+xref: RHEA:11872
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
[Term]
@@ -301314,6 +299491,7 @@ synonym: "cyclohexaglucanase activity" EXACT [EC:3.2.1.54]
synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" EXACT [EC:3.2.1.54]
xref: EC:3.2.1.54
xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN
+xref: RHEA:23980
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -301400,6 +299578,7 @@ synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" EXACT [EC:4
synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.13]
xref: EC:4.4.1.13
xref: MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN
+xref: RHEA:18121
is_a: GO:0016846 ! carbon-sulfur lyase activity
[Term]
@@ -301433,6 +299612,7 @@ synonym: "H2:ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1]
synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" EXACT [EC:1.12.2.1]
xref: EC:1.12.2.1
xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN
+xref: RHEA:20625
xref: UM-BBD_enzymeID:e0481
is_a: GO:0016697 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor
@@ -301563,7 +299743,7 @@ is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
id: GO:0047816
-name: D-arabinose 1-dehydrogenase (NAD) activity
+name: D-arabinose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN]
synonym: "arabinose(fucose)dehydrogenase activity" EXACT [EC:1.1.1.116]
@@ -301664,6 +299844,7 @@ synonym: "D-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1]
synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" EXACT [EC:2.3.2.1]
xref: EC:2.3.2.1
xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN
+xref: RHEA:35623
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
[Term]
@@ -301816,6 +299997,7 @@ synonym: "L-fucose (D-arabinose) dehydrogenase activity" EXACT [EC:1.1.1.122]
synonym: "L-fucose dehydrogenase activity" EXACT [EC:1.1.1.122]
xref: EC:1.1.1.122
xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN
+xref: RHEA:19645
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -301987,6 +300169,7 @@ synonym: "3'-deoxyribonucleotidase activity" EXACT [EC:3.1.3.34]
synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.34]
xref: EC:3.1.3.34
xref: MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN
+xref: RHEA:10092
is_a: GO:0016791 ! phosphatase activity
[Term]
@@ -302058,6 +300241,7 @@ synonym: "carboxylyl-CoA synthetase activity" EXACT [EC:6.2.1.23]
synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.23]
xref: EC:6.2.1.23
xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN
+xref: RHEA:14289
is_a: GO:0016878 ! acid-thiol ligase activity
[Term]
@@ -302071,6 +300255,7 @@ synonym: "transferrin reductase activity" EXACT [EC:1.16.1.2]
synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.2]
xref: EC:1.16.1.2
xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN
+xref: RHEA:13841
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
[Term]
@@ -302349,6 +300534,7 @@ synonym: "acyl-CoA:dolichol acyltransferase activity" EXACT [EC:2.3.1.123]
synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" EXACT [EC:2.3.1.123]
xref: EC:2.3.1.123
xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN
+xref: RHEA:16685
is_a: GO:0008374 ! O-acyltransferase activity
[Term]
@@ -302412,6 +300598,7 @@ synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" EX
synonym: "oligoglycosylglucosylceramide glycohydrolase activity" EXACT [EC:3.2.1.123]
xref: EC:3.2.1.123
xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN
+xref: RHEA:22288
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -302595,6 +300782,7 @@ synonym: "nitrate (ferredoxin) reductase activity" EXACT [EC:1.7.7.2]
synonym: "nitrite:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.2]
xref: EC:1.7.7.2
xref: MetaCyc:1.7.7.2-RXN
+xref: RHEA:21828
is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor
[Term]
@@ -302638,6 +300826,7 @@ synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity"
synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25]
xref: EC:2.4.2.25
xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN
+xref: RHEA:19153
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
@@ -302723,6 +300912,7 @@ synonym: "formate:cytochrome b1 oxidoreductase activity" EXACT [EC:1.2.2.1]
synonym: "formate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.1]
xref: EC:1.2.2.1
xref: MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN
+xref: RHEA:21520
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor
[Term]
@@ -302854,6 +301044,7 @@ synonym: "N5-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48]
synonym: "ornithine esterase activity" EXACT [EC:3.1.1.48]
xref: EC:3.1.1.48
xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN
+xref: RHEA:20165
is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
@@ -302894,6 +301085,7 @@ synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" EXACT [
synonym: "poly(galacturonate) hydrolase activity" EXACT [EC:3.2.1.67]
xref: EC:3.2.1.67
xref: MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN
+xref: RHEA:14117
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -302939,6 +301131,7 @@ synonym: "gamma-glutaminylhistamine synthetase activity" EXACT [EC:6.3.2.18]
synonym: "L-glutamate:histamine ligase activity" EXACT [EC:6.3.2.18]
xref: EC:6.3.2.18
xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN
+xref: RHEA:18881
is_a: GO:0016881 ! acid-amino acid ligase activity
[Term]
@@ -303416,6 +301609,7 @@ def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutami
synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" EXACT [EC:2.3.1.68]
xref: EC:2.3.1.68
xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN
+xref: RHEA:18469
is_a: GO:0016410 ! N-acyltransferase activity
[Term]
@@ -303488,7 +301682,7 @@ id: GO:0047952
name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
alt_id: GO:0036439
-def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN, RHEA:11096]
+def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [RHEA:11096]
synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.1.1.94]
synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT []
synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.94]
@@ -303596,6 +301790,7 @@ synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" EXACT [EC:1.4.
synonym: "reductase, glycine-cytochrome c" EXACT [EC:1.4.2.1]
xref: EC:1.4.2.1
xref: MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN
+xref: RHEA:16909
is_a: GO:0016640 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor
[Term]
@@ -303620,6 +301815,7 @@ synonym: "glycine-N-acylase activity" EXACT [EC:2.3.1.13]
xref: EC:2.3.1.13
xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN
xref: Reactome:R-HSA-2534040 "Unknown NAT N-acylates Gly in GNAT1"
+xref: RHEA:19869
is_a: GO:0016410 ! N-acyltransferase activity
[Term]
@@ -304233,7 +302429,7 @@ is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling path
id: GO:0048010
name: vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
-def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling, PR:000001971]
+def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]
comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
synonym: "VEGF receptor signaling pathway" EXACT []
synonym: "VEGF receptor signalling pathway" EXACT []
@@ -304568,18 +302764,18 @@ relationship: part_of GO:0007420 ! brain development
[Term]
id: GO:0048037
-name: cofactor binding
+name: obsolete cofactor binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
-subset: goslim_pir
-is_a: GO:0005488 ! binding
+def: "OBSOLETE. Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a cofactor.
+is_obsolete: true
[Term]
id: GO:0048038
name: quinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]
-is_a: GO:0048037 ! cofactor binding
+is_a: GO:0005488 ! binding
[Term]
id: GO:0048039
@@ -305560,7 +303756,7 @@ is_a: GO:0022605 ! mammalian oogenesis stage
id: GO:0048167
name: regulation of synaptic plasticity
namespace: biological_process
-def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290]
+def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0065008 ! regulation of biological quality
@@ -305569,7 +303765,7 @@ is_a: GO:0065008 ! regulation of biological quality
id: GO:0048168
name: regulation of neuronal synaptic plasticity
namespace: biological_process
-def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290]
+def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048167 ! regulation of synaptic plasticity
@@ -305577,7 +303773,7 @@ is_a: GO:0048167 ! regulation of synaptic plasticity
id: GO:0048169
name: regulation of long-term neuronal synaptic plasticity
namespace: biological_process
-def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290]
+def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity
@@ -305585,7 +303781,7 @@ is_a: GO:0048168 ! regulation of neuronal synaptic plasticity
id: GO:0048170
name: positive regulation of long-term neuronal synaptic plasticity
namespace: biological_process
-def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290]
+def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "activation of long-term neuronal synaptic plasticity" NARROW []
synonym: "stimulation of long-term neuronal synaptic plasticity" NARROW []
@@ -305599,7 +303795,7 @@ is_a: GO:0050769 ! positive regulation of neurogenesis
id: GO:0048171
name: negative regulation of long-term neuronal synaptic plasticity
namespace: biological_process
-def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290]
+def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "down regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "down-regulation of long-term neuronal synaptic plasticity" EXACT []
@@ -305612,7 +303808,7 @@ is_a: GO:0050768 ! negative regulation of neurogenesis
id: GO:0048172
name: regulation of short-term neuronal synaptic plasticity
namespace: biological_process
-def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
+def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity
@@ -305620,7 +303816,7 @@ is_a: GO:0048168 ! regulation of neuronal synaptic plasticity
id: GO:0048173
name: positive regulation of short-term neuronal synaptic plasticity
namespace: biological_process
-def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
+def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "activation of short-term neuronal synaptic plasticity" NARROW []
synonym: "stimulation of short-term neuronal synaptic plasticity" NARROW []
@@ -305634,7 +303830,7 @@ is_a: GO:0050769 ! positive regulation of neurogenesis
id: GO:0048174
name: negative regulation of short-term neuronal synaptic plasticity
namespace: biological_process
-def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290]
+def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]
comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "down regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "down-regulation of short-term neuronal synaptic plasticity" EXACT []
@@ -305741,7 +303937,7 @@ relationship: part_of GO:0005887 ! integral component of plasma membrane
id: GO:0048180
name: activin complex
namespace: cellular_component
-def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/]
+def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
subset: goslim_pir
is_a: GO:0032991 ! protein-containing complex
@@ -305751,7 +303947,7 @@ relationship: part_of GO:0005615 ! extracellular space
id: GO:0048183
name: activin AB complex
namespace: cellular_component
-def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/]
+def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
synonym: "inhibin beta-A" NARROW []
synonym: "inhibin beta-B" NARROW []
@@ -306372,7 +304568,6 @@ def: "The chemical reactions and pathways involving lauric acid, a fatty acid wi
synonym: "lauric acid metabolism" EXACT []
synonym: "n-dodecanoic acid metabolic process" EXACT []
synonym: "n-dodecanoic acid metabolism" EXACT []
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0051791 ! medium-chain fatty acid metabolic process
[Term]
@@ -306917,6 +305112,7 @@ def: "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite +
synonym: "ammonia:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.1]
xref: EC:1.7.7.1
xref: MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN
+xref: RHEA:18041
is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor
is_a: GO:0098809 ! nitrite reductase activity
@@ -312991,6 +311187,7 @@ synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.
synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170]
xref: EC:2.4.1.170
xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN
+xref: RHEA:56344
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -313579,6 +311776,7 @@ synonym: "delta7-sterol-C5(6)-desaturase activity" EXACT [EC:1.14.21.6]
synonym: "lathosterol 5-desaturase activity" EXACT [EC:1.14.21.6]
xref: EC:1.14.21.6
xref: MetaCyc:1.14.21.6-RXN
+xref: RHEA:46556
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated
is_a: GO:0070704 ! sterol desaturase activity
@@ -313681,6 +311879,7 @@ synonym: "sucrose 6-fructosyltransferase activity" EXACT [EC:2.4.1.10]
synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.10]
xref: EC:2.4.1.10
xref: MetaCyc:LEVANSUCRASE-RXN
+xref: RHEA:13653
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -313776,6 +311975,7 @@ synonym: "long-chain alcohol dehydrogenase activity" EXACT [EC:1.1.1.192]
synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.192]
xref: EC:1.1.1.192
xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN
+xref: RHEA:17977
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -313789,6 +311989,7 @@ synonym: "long-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48]
synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48]
xref: EC:1.2.1.48
xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN
+xref: RHEA:10652
xref: UM-BBD_reactionID:r1404
is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity
@@ -313803,6 +312004,7 @@ synonym: "long-chain fatty acyl-CoA reductase activity" EXACT [GOC:mah]
synonym: "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)" EXACT [EC:1.2.1.50]
xref: EC:1.2.1.50
xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
+xref: RHEA:15437
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -313929,6 +312131,7 @@ synonym: "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity" EXACT
synonym: "L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity" EXACT [EC:2.3.2.3]
xref: EC:2.3.2.3
xref: MetaCyc:LYSYLTRANSFERASE-RXN
+xref: RHEA:10668
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -313969,6 +312172,7 @@ synonym: "malyl coenzyme A synthetase activity" EXACT [EC:6.2.1.9]
synonym: "malyl-CoA synthetase activity" EXACT [EC:6.2.1.9]
xref: EC:6.2.1.9
xref: MetaCyc:MALATE--COA-LIGASE-RXN
+xref: RHEA:26193
is_a: GO:0016878 ! acid-thiol ligase activity
[Term]
@@ -314140,6 +312344,7 @@ synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.
synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2]
xref: EC:1.1.2.2
xref: MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN
+xref: RHEA:17597
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
[Term]
@@ -314354,6 +312559,7 @@ synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activi
synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.49]
xref: EC:2.4.1.49
xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN
+xref: RHEA:23024
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -314366,6 +312572,7 @@ synonym: "dextran dextrinase activity" EXACT [EC:2.4.1.2]
synonym: "dextrin 6-glucosyltransferase activity" EXACT [EC:2.4.1.2]
xref: EC:2.4.1.2
xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN
+xref: RHEA:14625
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -314768,6 +312975,7 @@ synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" EXACT [EC
synonym: "N-methylamino acid oxidase activity" EXACT [EC:1.5.3.2]
xref: EC:1.5.3.2
xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN
+xref: RHEA:11472
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
[Term]
@@ -314905,6 +313113,7 @@ synonym: "benzyl viologen-nitrate reductase activity" EXACT [EC:1.9.6.1]
synonym: "ferrocytochrome:nitrate oxidoreductase activity" EXACT [EC:1.9.6.1]
xref: EC:1.9.6.1
xref: MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN
+xref: RHEA:12909
is_a: GO:0016677 ! oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
[Term]
@@ -314926,6 +313135,7 @@ def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 ox
synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" EXACT [EC:1.19.6.1]
xref: EC:1.19.6.1
xref: MetaCyc:NITROGENASE-FLAVODOXIN-RXN
+xref: RHEA:15645
is_a: GO:0016738 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor
[Term]
@@ -314995,6 +313205,7 @@ synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.
xref: EC:2.7.1.77
xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN
xref: Reactome:R-HSA-2162066 "carbovir + IMP => carbovir monophosphate + inosine"
+xref: RHEA:19961
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019205 ! nucleobase-containing compound kinase activity
@@ -315021,6 +313232,7 @@ synonym: "nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4]
synonym: "nucleotide pyrophosphokinase activity" EXACT []
xref: EC:2.7.6.4
xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN
+xref: RHEA:12713
is_a: GO:0016778 ! diphosphotransferase activity
[Term]
@@ -315035,6 +313247,7 @@ synonym: "isophenoxazine synthase activity" EXACT [EC:1.10.3.4]
synonym: "o-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4]
xref: EC:1.10.3.4
xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN
+xref: RHEA:40963
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
[Term]
@@ -315078,6 +313291,7 @@ synonym: "omega-amidodicarboxylate amidohydrolase activity" EXACT [EC:3.5.1.3]
synonym: "w-amidase activity" EXACT []
xref: EC:3.5.1.3
xref: MetaCyc:OMEGA-AMIDASE-RXN
+xref: RHEA:11716
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -315110,14 +313324,13 @@ is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor
id: GO:0050155
name: ornithine(lysine) transaminase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN, RHEA:23792]
+def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN]
synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT []
synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT []
synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT []
synonym: "ornithine(lysine) aminotransferase activity" EXACT []
xref: EC:2.6.1.13
xref: MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN
-xref: RHEA:23792
is_a: GO:0008483 ! transaminase activity
[Term]
@@ -315319,6 +313532,7 @@ synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43]
synonym: "peptidyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.43]
xref: EC:3.5.1.43
xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN
+xref: RHEA:10032
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -315373,8 +313587,8 @@ id: GO:0050174
name: phenylalanine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN]
-synonym: "aromatic L-amino acid decarboxylase activity" EXACT [EC:4.1.1.53]
-synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [EC:4.1.1.53]
+synonym: "aromatic L-amino acid decarboxylase activity" BROAD []
+synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT []
synonym: "L-phenylalanine carboxy-lyase activity" EXACT [EC:4.1.1.53]
synonym: "L-phenylalanine decarboxylase activity" EXACT [EC:4.1.1.53]
xref: EC:4.1.1.53
@@ -315862,13 +314076,10 @@ id: GO:0050208
name: polysialic-acid O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN]
-synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [EC:2.3.1.136]
-synonym: "lecithin retinol acyl transferase activity" EXACT [EC:2.3.1.136]
-synonym: "lecithin:retinol acyltransferase activity" EXACT [EC:2.3.1.136]
-synonym: "LRAT" RELATED [EC:2.3.1.136]
-synonym: "retinyl ester synthase activity" EXACT [EC:2.3.1.136]
+synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT []
xref: EC:2.3.1.136
xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN
+xref: RHEA:11604
is_a: GO:0016413 ! O-acetyltransferase activity
[Term]
@@ -315881,6 +314092,7 @@ synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.30]
synonym: "PVA oxidase activity" EXACT [EC:1.1.3.30]
xref: EC:1.1.3.30
xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN
+xref: RHEA:21688
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
[Term]
@@ -315914,6 +314126,7 @@ xref: EC:2.4.1.50
xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN
xref: Reactome:R-HSA-1981120 "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2."
xref: Reactome:R-HSA-1981128 "Galactosylation of collagen propeptide hydroxylysines by PLOD3"
+xref: RHEA:12637
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -316142,6 +314355,7 @@ synonym: "PAPS:psychosine sulphotransferase activity" EXACT [EC:2.8.2.13]
synonym: "psychosine sulphotransferase activity" EXACT []
xref: EC:2.8.2.13
xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN
+xref: RHEA:14137
is_a: GO:0008146 ! sulfotransferase activity
[Term]
@@ -316152,6 +314366,7 @@ def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-d
synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.17.3.1]
xref: EC:1.17.3.1
xref: MetaCyc:PTERIDINE-OXIDASE-RXN
+xref: RHEA:12777
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
[Term]
@@ -316542,6 +314757,7 @@ synonym: "STK14" RELATED [EC:2.7.11.14]
xref: EC:2.7.11.14
xref: MetaCyc:2.7.11.14-RXN
xref: Reactome:R-HSA-2581474 "GRK1,4,7 phosphorylate MII to p-MII"
+xref: RHEA:23356
is_a: GO:0004672 ! protein kinase activity
[Term]
@@ -316674,6 +314890,7 @@ synonym: "RihB" RELATED [EC:3.2.2.8]
synonym: "YeiK" RELATED [EC:3.2.2.8]
xref: EC:3.2.2.8
xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN
+xref: RHEA:56816
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
[Term]
@@ -316703,6 +314920,7 @@ synonym: "UTP:RNA uridylyltransferase activity" EXACT []
xref: EC:2.7.7.52
xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN
xref: Reactome:R-HSA-8941312 "ZCCHC6, ZCCHC11 are mRNA uridyltransferases"
+xref: RHEA:14785
is_a: GO:0070569 ! uridylyltransferase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA
@@ -316734,6 +314952,7 @@ synonym: "rubber prenyltransferase activity" EXACT [EC:2.5.1.20]
synonym: "rubber transferase activity" BROAD [EC:2.5.1.20]
xref: EC:2.5.1.20
xref: MetaCyc:2.5.1.20-RXN
+xref: RHEA:18801
is_a: GO:0002094 ! polyprenyltransferase activity
[Term]
@@ -317235,7 +315454,7 @@ is_a: GO:0018488 ! aryl-aldehyde oxidase activity
id: GO:0050303
name: lysine 6-dehydrogenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN, RHEA:25117]
+def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN, RHEA:12408]
synonym: "L-lysine 6-dehydrogenase activity" EXACT [EC:1.4.1.18]
synonym: "L-lysine epsilon-dehydrogenase activity" EXACT [EC:1.4.1.18]
synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" EXACT [EC:1.4.1.18]
@@ -317243,7 +315462,7 @@ synonym: "LysDH activity" EXACT [EC:1.4.1.18]
xref: EC:1.4.1.18
xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN
xref: MetaCyc:PWY-5314
-xref: RHEA:25125
+xref: RHEA:12408
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
[Term]
@@ -317258,6 +315477,7 @@ synonym: "nitrous oxide reductase activity" EXACT [EC:1.7.2.4]
xref: EC:1.7.2.4
xref: KEGG_REACTION:R02804
xref: MetaCyc:RXN-12130
+xref: RHEA:43108
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
[Term]
@@ -317339,6 +315559,7 @@ synonym: "sulfite:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.1]
synonym: "sulphite dehydrogenase activity" EXACT []
xref: EC:1.8.2.1
xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN
+xref: RHEA:14281
is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor
[Term]
@@ -317351,6 +315572,7 @@ synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" EXACT [EC:1.8.7.1
synonym: "sulphite reductase (ferredoxin) activity" EXACT []
xref: EC:1.8.7.1
xref: MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN
+xref: RHEA:23132
is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor
[Term]
@@ -317375,6 +315597,7 @@ synonym: "sulphur dioxygenase activity" EXACT []
xref: EC:1.13.11.18
xref: MetaCyc:FESGSHTHIO-RXN
xref: Reactome:R-HSA-1614605 "Persulfide sulfur is dioxygenated"
+xref: RHEA:12981
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
[Term]
@@ -317409,6 +315632,7 @@ def: "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP
synonym: "ATP:(d)NMP phosphotransferase activity" EXACT [EC:2.7.4.12]
xref: EC:2.7.4.12
xref: MetaCyc:GMKALT-RXN
+xref: RHEA:12697
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
@@ -317725,6 +315949,7 @@ synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2
synonym: "thiosulphate dehydrogenase activity" EXACT []
xref: EC:1.8.2.2
xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN
+xref: RHEA:20549
is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor
[Term]
@@ -317794,6 +316019,7 @@ def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NAD
synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.44]
xref: EC:1.3.1.44
xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN
+xref: RHEA:18177
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -318192,6 +316418,7 @@ synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" EXACT [EC:
synonym: "tyrosine 3-monooxygenase kinase activity" EXACT []
xref: EC:2.7.11.6
xref: MetaCyc:2.7.11.6-RXN
+xref: RHEA:17133
is_a: GO:0004672 ! protein kinase activity
[Term]
@@ -318203,6 +316430,7 @@ synonym: "CYP79A1 activity" NARROW []
synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT []
synonym: "tyrosine N-hydroxylase activity" EXACT []
xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN
+xref: RHEA:22464
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -318371,6 +316599,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [EC:1.17.99.4, MetaCyc:URACIL-DEHYDROGENASE-RXN]
xref: EC:1.17.99.4
xref: MetaCyc:URACIL-DEHYDROGENASE-RXN
+xref: RHEA:22752
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
[Term]
@@ -318578,6 +316807,7 @@ synonym: "wax-ester acylhydrolase activity" EXACT [EC:3.1.1.50]
synonym: "WEH" RELATED [EC:3.1.1.50]
xref: EC:3.1.1.50
xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN
+xref: RHEA:13577
is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
@@ -318689,6 +316919,7 @@ synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27]
synonym: "STK5" RELATED [EC:2.7.11.27]
xref: EC:2.7.11.27
xref: MetaCyc:2.7.11.27-RXN
+xref: RHEA:20333
is_a: GO:0004672 ! protein kinase activity
[Term]
@@ -318700,6 +316931,7 @@ synonym: "acetyl-CoA carboxylase-phosphatase activity" EXACT [EC:3.1.3.44]
synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.44]
xref: EC:3.1.3.44
xref: MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN
+xref: RHEA:17125
is_a: GO:0004721 ! phosphoprotein phosphatase activity
[Term]
@@ -318922,6 +317154,7 @@ synonym: "NO-forming nitrite reductase activity" EXACT []
synonym: "Pseudomonas cytochrome oxidase activity" NARROW [EC:1.7.2.1]
xref: EC:1.7.2.1
xref: MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN
+xref: RHEA:15233
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
is_a: GO:0098809 ! nitrite reductase activity
@@ -318961,8 +317194,6 @@ def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine
comment: This term was made obsolete because it represents a gene product.
synonym: "alanine carboxypeptidase activity" EXACT []
synonym: "N-benzoyl-L-alanine-amidohydrolase activity" EXACT [EC:3.4.17.6]
-xref: EC:3.4.17.6
-xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004181
@@ -318977,8 +317208,6 @@ synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2]
synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" EXACT [EC:3.4.17.2]
synonym: "protaminase activity" RELATED [EC:3.4.17.2]
synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2]
-xref: EC:3.4.17.2
-xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN
is_obsolete: true
replaced_by: GO:0004181
@@ -318994,8 +317223,6 @@ synonym: "peptidyl amino acid amide hydrolase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl carboxy-amidase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl carboxyamidase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl-glycinamidase activity" EXACT []
-xref: EC:3.4.19.2
-xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN
is_obsolete: true
replaced_by: GO:0008242
@@ -319358,6 +317585,7 @@ synonym: "NADH2:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14]
synonym: "NADH:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14]
xref: EC:1.8.1.14
xref: MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN
+xref: RHEA:14705
is_a: GO:0015036 ! disulfide oxidoreductase activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
@@ -319487,7 +317715,7 @@ synonym: "O-phosphorylethanol-amine phospho-lyase activity" EXACT [EC:4.2.3.2]
xref: EC:4.2.3.2
xref: KEGG_REACTION:R00748
xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN
-xref: Reactome:R-HSA-5696415 "ETNPPL tetramer hydrolyses PETA"
+xref: Reactome:R-HSA-5696415 "PXLP-K278-ETNPPL tetramer hydrolyses PETA"
xref: RHEA:17889
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
@@ -319653,6 +317881,7 @@ synonym: "TMADh activity" RELATED [EC:1.5.8.2]
synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" EXACT [EC:1.5.8.2]
xref: EC:1.5.8.2
xref: MetaCyc:1.5.8.2-RXN
+xref: RHEA:11864
xref: UM-BBD_enzymeID:e0854
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor
@@ -319785,6 +318014,7 @@ synonym: "O-alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5]
xref: EC:1.14.16.5
xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN
xref: Reactome:R-HSA-5696119 "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol"
+xref: RHEA:36255
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
[Term]
@@ -319833,6 +318063,7 @@ def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai]
synonym: "IMP 5' nucleotidase activity" EXACT []
synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED []
xref: MetaCyc:RXN-7607
+xref: RHEA:27718
is_a: GO:0008253 ! 5'-nucleotidase activity
[Term]
@@ -319843,6 +318074,7 @@ def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai]
synonym: "GMP 5' nucleotidase activity" EXACT []
synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED []
xref: MetaCyc:RXN-7609
+xref: RHEA:27714
is_a: GO:0008253 ! 5'-nucleotidase activity
[Term]
@@ -319894,6 +318126,7 @@ synonym: "1,4-lactone hydroxyacylhydrolase activity" EXACT [EC:3.1.1.25]
synonym: "gamma-lactonase activity" EXACT [EC:3.1.1.25]
xref: EC:3.1.1.25
xref: MetaCyc:14-LACTONASE-RXN
+xref: RHEA:12745
is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
@@ -319916,6 +318149,7 @@ def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H
synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.261]
xref: EC:1.1.1.261
xref: MetaCyc:1.1.1.261-RXN
+xref: RHEA:21412
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -320014,6 +318248,7 @@ synonym: "spHAS" RELATED [EC:2.4.1.212]
xref: EC:2.4.1.212
xref: MetaCyc:2.4.1.212-RXN
xref: Reactome:R-HSA-2160851 "HAS1,2,3 mediate the polymerisation of HA"
+xref: RHEA:12528
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -320115,6 +318350,7 @@ xref: Reactome:R-HSA-3656254 "Defective EXT2 (in EXT1:EXT2) does not transfer Gl
xref: Reactome:R-HSA-3656261 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain"
xref: Reactome:R-HSA-9036283 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue"
xref: Reactome:R-HSA-9036290 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan"
+xref: RHEA:16213
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
[Term]
@@ -320134,6 +318370,7 @@ xref: Reactome:R-HSA-3656257 "Defective EXT1 (in EXT1:EXT2) does not transfer Gl
xref: Reactome:R-HSA-3656267 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan"
xref: Reactome:R-HSA-9036285 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan"
xref: Reactome:R-HSA-9036289 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan"
+xref: RHEA:20908
is_a: GO:0015020 ! glucuronosyltransferase activity
[Term]
@@ -320164,6 +318401,7 @@ synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activ
synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT []
xref: EC:2.4.1.227
xref: MetaCyc:RXN-8976
+xref: RHEA:23192
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
[Term]
@@ -320292,6 +318530,7 @@ synonym: "CitX" RELATED [EC:2.7.7.61]
synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61]
xref: EC:2.7.7.61
xref: MetaCyc:2.7.7.61-RXN
+xref: RHEA:16333
is_a: GO:0016779 ! nucleotidyltransferase activity
[Term]
@@ -320321,6 +318560,7 @@ synonym: "GWD" RELATED [EC:2.7.9.4]
synonym: "starch-related R1 protein activity" EXACT [EC:2.7.9.4]
xref: EC:2.7.9.4
xref: MetaCyc:2.7.9.4-RXN
+xref: RHEA:11668
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors
@@ -320385,6 +318625,7 @@ synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" EXACT [EC:3.1.1.75]
synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75]
xref: EC:3.1.1.75
xref: MetaCyc:3.1.1.75-RXN
+xref: RHEA:11248
is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
@@ -320414,6 +318655,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN]
xref: EC:3.1.1.77
xref: MetaCyc:3.1.1.77-RXN
+xref: RHEA:12032
is_a: GO:0052689 ! carboxylic ester hydrolase activity
[Term]
@@ -320502,6 +318744,7 @@ synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)
synonym: "b-primeverosidase activity" EXACT []
xref: EC:3.2.1.149
xref: MetaCyc:3.2.1.149-RXN
+xref: RHEA:24480
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -320539,6 +318782,7 @@ synonym: "L-carbamoylase activity" EXACT [EC:3.5.1.87]
synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" EXACT [EC:3.5.1.87]
xref: EC:3.5.1.87
xref: MetaCyc:3.5.1.87-RXN
+xref: RHEA:17581
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -320756,6 +319000,7 @@ synonym: "epoxypropane:coenzyme M transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxypropyl:CoM transferase activity" EXACT [EC:4.4.1.23]
xref: EC:4.4.1.23
xref: MetaCyc:4.2.99.19-RXN
+xref: RHEA:19421
xref: UM-BBD_enzymeID:e0538
is_a: GO:0016846 ! carbon-sulfur lyase activity
@@ -320820,6 +319065,7 @@ synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" EXACT [EC:6.1.1.23]
synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23]
xref: EC:6.1.1.23
xref: MetaCyc:6.1.1.23-RXN
+xref: RHEA:18349
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity
[Term]
@@ -320854,6 +319100,7 @@ synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" EXACT [EC:6.2.1.34]
synonym: "trans-feruloyl-CoA synthetase activity" EXACT [EC:6.2.1.34]
xref: EC:6.2.1.34
xref: MetaCyc:6.2.1.34-RXN
+xref: RHEA:19389
is_a: GO:0016878 ! acid-thiol ligase activity
[Term]
@@ -320997,13 +319244,13 @@ is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors,
id: GO:0050573
name: dTDP-4-dehydro-6-deoxyglucose reductase activity
namespace: molecular_function
-def: "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH." [EC:1.1.1.266, RHEA:21903]
+def: "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH." [EC:1.1.1.266, RHEA:36586]
synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.1.1.266]
synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.266]
xref: EC:1.1.1.266
xref: KEGG_REACTION:R05687
xref: MetaCyc:1.1.1.266-RXN
-xref: RHEA:21903
+xref: RHEA:36586
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -321060,6 +319307,7 @@ synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272]
synonym: "L-sulfolactate dehydrogenase activity" EXACT [EC:1.1.1.272]
xref: EC:1.1.1.272
xref: MetaCyc:1.1.1.272-RXN
+xref: RHEA:35735
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -321431,6 +319679,7 @@ synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2]
synonym: "rubredoxin:superoxide oxidoreductase activity" EXACT [EC:1.15.1.2]
xref: EC:1.15.1.2
xref: MetaCyc:1.15.1.2-RXN
+xref: RHEA:21324
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor
@@ -321514,6 +319763,7 @@ synonym: "arsenite oxidase activity" EXACT [EC:1.20.9.1]
synonym: "arsenite:azurin oxidoreductase activity" EXACT [EC:1.20.9.1]
xref: EC:1.20.9.1
xref: MetaCyc:1.20.98.1-RXN
+xref: RHEA:18701
xref: UM-BBD_reactionID:r0634
is_a: GO:0052882 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor
@@ -321596,6 +319846,7 @@ def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin =
synonym: "PebA" RELATED [EC:1.3.7.2]
xref: EC:1.3.7.2
xref: MetaCyc:1.3.7.2-RXN
+xref: RHEA:10168
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
[Term]
@@ -321607,6 +319858,7 @@ synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" EXACT [EC:1
synonym: "PebB" RELATED [EC:1.3.7.3]
xref: EC:1.3.7.3
xref: MetaCyc:1.3.7.3-RXN
+xref: RHEA:22092
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
[Term]
@@ -321622,6 +319874,7 @@ synonym: "phytochromobilin synthase activity" EXACT [EC:1.3.7.4]
synonym: "PPhiB synthase activity" EXACT [EC:1.3.7.4]
xref: EC:1.3.7.4
xref: MetaCyc:1.3.7.4-RXN
+xref: RHEA:16377
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
[Term]
@@ -321632,6 +319885,7 @@ def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = bi
synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.5]
xref: EC:1.3.7.5
xref: MetaCyc:1.3.7.5-RXN
+xref: RHEA:15309
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
[Term]
@@ -321716,6 +319970,7 @@ synonym: "TOR activity" EXACT [EC:1.7.2.3]
synonym: "trimethylamine:cytochrome c oxidoreductase activity" EXACT [EC:1.7.2.3]
xref: EC:1.7.2.3
xref: MetaCyc:1.7.2.3-RXN
+xref: RHEA:24236
xref: Wikipedia:Trimethylamine_N-oxide_reductase
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
@@ -321996,7 +320251,6 @@ name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0036041 ! long-chain fatty acid binding
is_a: GO:0050542 ! icosanoid binding
@@ -322166,7 +320420,6 @@ synonym: "FAD or FADH2 binding" EXACT []
synonym: "flavine-adenine dinucleotide binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0043168 ! anion binding
-is_a: GO:0050662 ! coenzyme binding
[Term]
id: GO:0050661
@@ -322177,15 +320430,14 @@ synonym: "NADP or NADPH binding" RELATED [GOC:mah]
synonym: "NADP+ or NADPH binding" RELATED []
synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
-is_a: GO:0050662 ! coenzyme binding
[Term]
id: GO:0050662
-name: coenzyme binding
+name: obsolete coenzyme binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
-subset: goslim_metagenomics
-is_a: GO:0048037 ! cofactor binding
+def: "OBSOLETE. Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a coenzyme.
+is_obsolete: true
[Term]
id: GO:0050663
@@ -322218,9 +320470,8 @@ synonym: "hydrogen peroxide biosynthesis" EXACT []
synonym: "hydrogen peroxide formation" EXACT []
synonym: "hydrogen peroxide generation" EXACT []
synonym: "hydrogen peroxide synthesis" EXACT []
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0042743 ! hydrogen peroxide metabolic process
-is_a: GO:0051188 ! cofactor biosynthetic process
+is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:1903409 ! reactive oxygen species biosynthetic process
[Term]
@@ -322609,7 +320860,6 @@ synonym: "trichloroethylene catabolism" EXACT []
synonym: "trichloroethylene degradation" EXACT []
is_a: GO:0018979 ! trichloroethylene metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
-is_a: GO:0042737 ! drug catabolic process
[Term]
id: GO:0050697
@@ -322645,66 +320895,6 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670]
is_a: GO:0019904 ! protein domain specific binding
-[Term]
-id: GO:0050701
-name: interleukin-1 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-1 from a cell. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response." [GOC:ai, ISBN:0198506732]
-synonym: "IL-1 secretion" EXACT []
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032612 ! interleukin-1 production
-
-[Term]
-id: GO:0050702
-name: interleukin-1 beta secretion
-namespace: biological_process
-def: "The regulated release of interleukin 1 beta from a cell." [GOC:ai]
-synonym: "IL-1b secretion" EXACT []
-is_a: GO:0050701 ! interleukin-1 secretion
-relationship: part_of GO:0032611 ! interleukin-1 beta production
-
-[Term]
-id: GO:0050703
-name: interleukin-1 alpha secretion
-namespace: biological_process
-def: "The regulated release of interleukin-1 alpha from a cell." [GOC:ai]
-synonym: "IL-1a secretion" EXACT []
-is_a: GO:0050701 ! interleukin-1 secretion
-relationship: part_of GO:0032610 ! interleukin-1 alpha production
-
-[Term]
-id: GO:0050704
-name: regulation of interleukin-1 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai]
-is_a: GO:0032652 ! regulation of interleukin-1 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0050701 ! interleukin-1 secretion
-relationship: regulates GO:0050701 ! interleukin-1 secretion
-
-[Term]
-id: GO:0050705
-name: regulation of interleukin-1 alpha secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai]
-is_a: GO:0032650 ! regulation of interleukin-1 alpha production
-is_a: GO:0050704 ! regulation of interleukin-1 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0050703 ! interleukin-1 alpha secretion
-relationship: regulates GO:0050703 ! interleukin-1 alpha secretion
-
-[Term]
-id: GO:0050706
-name: regulation of interleukin-1 beta secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai]
-is_a: GO:0032651 ! regulation of interleukin-1 beta production
-is_a: GO:0050704 ! regulation of interleukin-1 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0050702 ! interleukin-1 beta secretion
-relationship: regulates GO:0050702 ! interleukin-1 beta secretion
-
[Term]
id: GO:0050707
name: regulation of cytokine secretion
@@ -322765,54 +320955,6 @@ intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0050663 ! cytokine secretion
relationship: negatively_regulates GO:0050663 ! cytokine secretion
-[Term]
-id: GO:0050711
-name: negative regulation of interleukin-1 secretion
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai]
-synonym: "down regulation of interleukin-1 secretion" EXACT []
-synonym: "down-regulation of interleukin-1 secretion" EXACT []
-synonym: "downregulation of interleukin-1 secretion" EXACT []
-synonym: "inhibition of interleukin-1 secretion" NARROW []
-is_a: GO:0032692 ! negative regulation of interleukin-1 production
-is_a: GO:0050704 ! regulation of interleukin-1 secretion
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0050701 ! interleukin-1 secretion
-relationship: negatively_regulates GO:0050701 ! interleukin-1 secretion
-
-[Term]
-id: GO:0050712
-name: negative regulation of interleukin-1 alpha secretion
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai]
-synonym: "down regulation of interleukin-1 alpha secretion" EXACT []
-synonym: "down-regulation of interleukin-1 alpha secretion" EXACT []
-synonym: "downregulation of interleukin-1 alpha secretion" EXACT []
-synonym: "inhibition of interleukin-1 alpha secretion" NARROW []
-is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production
-is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion
-is_a: GO:0050711 ! negative regulation of interleukin-1 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion
-relationship: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion
-
-[Term]
-id: GO:0050713
-name: negative regulation of interleukin-1 beta secretion
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai]
-synonym: "down regulation of interleukin-1 beta secretion" EXACT []
-synonym: "down-regulation of interleukin-1 beta secretion" EXACT []
-synonym: "downregulation of interleukin-1 beta secretion" EXACT []
-synonym: "inhibition of interleukin-1 beta secretion" NARROW []
-is_a: GO:0032691 ! negative regulation of interleukin-1 beta production
-is_a: GO:0050706 ! regulation of interleukin-1 beta secretion
-is_a: GO:0050711 ! negative regulation of interleukin-1 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0050702 ! interleukin-1 beta secretion
-relationship: negatively_regulates GO:0050702 ! interleukin-1 beta secretion
-
[Term]
id: GO:0050714
name: positive regulation of protein secretion
@@ -322850,193 +320992,6 @@ intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0050663 ! cytokine secretion
relationship: positively_regulates GO:0050663 ! cytokine secretion
-[Term]
-id: GO:0050716
-name: positive regulation of interleukin-1 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai]
-synonym: "activation of interleukin-1 secretion" NARROW []
-synonym: "stimulation of interleukin-1 secretion" NARROW []
-synonym: "up regulation of interleukin-1 secretion" EXACT []
-synonym: "up-regulation of interleukin-1 secretion" EXACT []
-synonym: "upregulation of interleukin-1 secretion" EXACT []
-is_a: GO:0032732 ! positive regulation of interleukin-1 production
-is_a: GO:0050704 ! regulation of interleukin-1 secretion
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0050701 ! interleukin-1 secretion
-relationship: positively_regulates GO:0050701 ! interleukin-1 secretion
-
-[Term]
-id: GO:0050717
-name: positive regulation of interleukin-1 alpha secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai]
-synonym: "activation of interleukin-1 alpha secretion" NARROW []
-synonym: "stimulation of interleukin-1 alpha secretion" NARROW []
-synonym: "up regulation of interleukin-1 alpha secretion" EXACT []
-synonym: "up-regulation of interleukin-1 alpha secretion" EXACT []
-synonym: "upregulation of interleukin-1 alpha secretion" EXACT []
-is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production
-is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion
-is_a: GO:0050716 ! positive regulation of interleukin-1 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0050703 ! interleukin-1 alpha secretion
-relationship: positively_regulates GO:0050703 ! interleukin-1 alpha secretion
-
-[Term]
-id: GO:0050718
-name: positive regulation of interleukin-1 beta secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai]
-synonym: "activation of interleukin-1 beta secretion" NARROW []
-synonym: "stimulation of interleukin-1 beta secretion" NARROW []
-synonym: "up regulation of interleukin-1 beta secretion" EXACT []
-synonym: "up-regulation of interleukin-1 beta secretion" EXACT []
-synonym: "upregulation of interleukin-1 beta secretion" EXACT []
-is_a: GO:0032731 ! positive regulation of interleukin-1 beta production
-is_a: GO:0050706 ! regulation of interleukin-1 beta secretion
-is_a: GO:0050716 ! positive regulation of interleukin-1 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0050702 ! interleukin-1 beta secretion
-relationship: positively_regulates GO:0050702 ! interleukin-1 beta secretion
-
-[Term]
-id: GO:0050719
-name: interleukin-1 alpha biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
-synonym: "interleukin-1 alpha anabolism" EXACT []
-synonym: "interleukin-1 alpha biosynthesis" EXACT []
-synonym: "interleukin-1 alpha formation" EXACT []
-synonym: "interleukin-1 alpha synthesis" EXACT []
-is_a: GO:0042222 ! interleukin-1 biosynthetic process
-relationship: part_of GO:0032610 ! interleukin-1 alpha production
-
-[Term]
-id: GO:0050720
-name: interleukin-1 beta biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
-synonym: "interleukin-1 beta anabolism" EXACT []
-synonym: "interleukin-1 beta biosynthesis" EXACT []
-synonym: "interleukin-1 beta formation" EXACT []
-synonym: "interleukin-1 beta synthesis" EXACT []
-is_a: GO:0042222 ! interleukin-1 biosynthetic process
-relationship: part_of GO:0032611 ! interleukin-1 beta production
-
-[Term]
-id: GO:0050721
-name: regulation of interleukin-1 alpha biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
-synonym: "regulation of interleukin-1 alpha anabolism" EXACT []
-synonym: "regulation of interleukin-1 alpha biosynthesis" EXACT []
-synonym: "regulation of interleukin-1 alpha formation" EXACT []
-synonym: "regulation of interleukin-1 alpha synthesis" EXACT []
-is_a: GO:0032650 ! regulation of interleukin-1 alpha production
-is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process
-relationship: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process
-
-[Term]
-id: GO:0050722
-name: regulation of interleukin-1 beta biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
-synonym: "regulation of interleukin-1 beta anabolism" EXACT []
-synonym: "regulation of interleukin-1 beta biosynthesis" EXACT []
-synonym: "regulation of interleukin-1 beta formation" EXACT []
-synonym: "regulation of interleukin-1 beta synthesis" EXACT []
-is_a: GO:0032651 ! regulation of interleukin-1 beta production
-is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0050720 ! interleukin-1 beta biosynthetic process
-relationship: regulates GO:0050720 ! interleukin-1 beta biosynthetic process
-
-[Term]
-id: GO:0050723
-name: negative regulation of interleukin-1 alpha biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
-synonym: "down regulation of interleukin-1 alpha biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-1 alpha biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-1 alpha biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-1 alpha biosynthetic process" NARROW []
-synonym: "negative regulation of interleukin-1 alpha anabolism" EXACT []
-synonym: "negative regulation of interleukin-1 alpha biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-1 alpha formation" EXACT []
-synonym: "negative regulation of interleukin-1 alpha synthesis" EXACT []
-is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production
-is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process
-is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process
-relationship: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process
-
-[Term]
-id: GO:0050724
-name: negative regulation of interleukin-1 beta biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
-synonym: "down regulation of interleukin-1 beta biosynthetic process" EXACT []
-synonym: "down-regulation of interleukin-1 beta biosynthetic process" EXACT []
-synonym: "downregulation of interleukin-1 beta biosynthetic process" EXACT []
-synonym: "inhibition of interleukin-1 beta biosynthetic process" NARROW []
-synonym: "negative regulation of interleukin-1 beta anabolism" EXACT []
-synonym: "negative regulation of interleukin-1 beta biosynthesis" EXACT []
-synonym: "negative regulation of interleukin-1 beta formation" EXACT []
-synonym: "negative regulation of interleukin-1 beta synthesis" EXACT []
-is_a: GO:0032691 ! negative regulation of interleukin-1 beta production
-is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process
-is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process
-relationship: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process
-
-[Term]
-id: GO:0050725
-name: positive regulation of interleukin-1 beta biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
-synonym: "activation of interleukin-1 beta biosynthetic process" NARROW []
-synonym: "positive regulation of interleukin-1 beta anabolism" EXACT []
-synonym: "positive regulation of interleukin-1 beta biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-1 beta formation" EXACT []
-synonym: "positive regulation of interleukin-1 beta synthesis" EXACT []
-synonym: "stimulation of interleukin-1 beta biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-1 beta biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-1 beta biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-1 beta biosynthetic process" EXACT []
-is_a: GO:0032731 ! positive regulation of interleukin-1 beta production
-is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process
-is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process
-relationship: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process
-
-[Term]
-id: GO:0050726
-name: positive regulation of interleukin-1 alpha biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
-synonym: "activation of interleukin-1 alpha biosynthetic process" NARROW []
-synonym: "positive regulation of interleukin-1 alpha anabolism" EXACT []
-synonym: "positive regulation of interleukin-1 alpha biosynthesis" EXACT []
-synonym: "positive regulation of interleukin-1 alpha formation" EXACT []
-synonym: "positive regulation of interleukin-1 alpha synthesis" EXACT []
-synonym: "stimulation of interleukin-1 alpha biosynthetic process" NARROW []
-synonym: "up regulation of interleukin-1 alpha biosynthetic process" EXACT []
-synonym: "up-regulation of interleukin-1 alpha biosynthetic process" EXACT []
-synonym: "upregulation of interleukin-1 alpha biosynthetic process" EXACT []
-is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production
-is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process
-is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process
-relationship: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process
-
[Term]
id: GO:0050727
name: regulation of inflammatory response
@@ -323295,96 +321250,6 @@ synonym: "LDL receptor binding" EXACT []
synonym: "low-density lipoprotein receptor binding" EXACT [GOC:dph]
is_a: GO:0070325 ! lipoprotein particle receptor binding
-[Term]
-id: GO:0050751
-name: fractalkine biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de]
-synonym: "ABCD-3 biosynthesis" EXACT []
-synonym: "ABCD-3 biosynthetic process" EXACT []
-synonym: "CX3C membrane-anchored chemokine biosynthesis" EXACT []
-synonym: "CX3C membrane-anchored chemokine biosynthetic process" EXACT []
-synonym: "CX3CL1 biosynthesis" EXACT []
-synonym: "CX3CL1 biosynthetic process" EXACT []
-synonym: "fractalkine anabolism" EXACT []
-synonym: "fractalkine biosynthesis" EXACT []
-synonym: "fractalkine formation" EXACT []
-synonym: "fractalkine synthesis" EXACT []
-synonym: "neurotactin biosynthesis" EXACT []
-synonym: "neurotactin biosynthetic process" EXACT []
-is_a: GO:0042033 ! chemokine biosynthetic process
-is_a: GO:0050756 ! fractalkine metabolic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0032603 ! fractalkine production
-
-[Term]
-id: GO:0050752
-name: regulation of fractalkine biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]
-synonym: "regulation of CX3CL1 biosynthesis" EXACT []
-synonym: "regulation of CX3CL1 biosynthetic process" EXACT []
-synonym: "regulation of fractalkine anabolism" EXACT []
-synonym: "regulation of fractalkine biosynthesis" EXACT []
-synonym: "regulation of fractalkine formation" EXACT []
-synonym: "regulation of fractalkine synthesis" EXACT []
-synonym: "regulation of neurotactin biosynthesis" EXACT []
-synonym: "regulation of neurotactin biosynthetic process" EXACT []
-is_a: GO:0032644 ! regulation of fractalkine production
-is_a: GO:0045073 ! regulation of chemokine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0050751 ! fractalkine biosynthetic process
-relationship: regulates GO:0050751 ! fractalkine biosynthetic process
-
-[Term]
-id: GO:0050753
-name: negative regulation of fractalkine biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]
-synonym: "down regulation of fractalkine biosynthetic process" EXACT []
-synonym: "down-regulation of fractalkine biosynthetic process" EXACT []
-synonym: "downregulation of fractalkine biosynthetic process" EXACT []
-synonym: "inhibition of fractalkine biosynthetic process" NARROW []
-synonym: "negative regulation of CX3CL1 biosynthesis" EXACT []
-synonym: "negative regulation of CX3CL1 biosynthetic process" EXACT []
-synonym: "negative regulation of fractalkine anabolism" EXACT []
-synonym: "negative regulation of fractalkine biosynthesis" EXACT []
-synonym: "negative regulation of fractalkine formation" EXACT []
-synonym: "negative regulation of fractalkine synthesis" EXACT []
-synonym: "negative regulation of neurotactin biosynthesis" EXACT []
-synonym: "negative regulation of neurotactin biosynthetic process" EXACT []
-is_a: GO:0032684 ! negative regulation of fractalkine production
-is_a: GO:0045079 ! negative regulation of chemokine biosynthetic process
-is_a: GO:0050752 ! regulation of fractalkine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0050751 ! fractalkine biosynthetic process
-relationship: negatively_regulates GO:0050751 ! fractalkine biosynthetic process
-
-[Term]
-id: GO:0050754
-name: positive regulation of fractalkine biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]
-synonym: "activation of fractalkine biosynthetic process" NARROW []
-synonym: "positive regulation of CX3CL1 biosynthesis" EXACT []
-synonym: "positive regulation of CX3CL1 biosynthetic process" EXACT []
-synonym: "positive regulation of fractalkine anabolism" EXACT []
-synonym: "positive regulation of fractalkine biosynthesis" EXACT []
-synonym: "positive regulation of fractalkine formation" EXACT []
-synonym: "positive regulation of fractalkine synthesis" EXACT []
-synonym: "positive regulation of neurotactin biosynthesis" EXACT []
-synonym: "positive regulation of neurotactin biosynthetic process" EXACT []
-synonym: "stimulation of fractalkine biosynthetic process" NARROW []
-synonym: "up regulation of fractalkine biosynthetic process" EXACT []
-synonym: "up-regulation of fractalkine biosynthetic process" EXACT []
-synonym: "upregulation of fractalkine biosynthetic process" EXACT []
-is_a: GO:0032724 ! positive regulation of fractalkine production
-is_a: GO:0045080 ! positive regulation of chemokine biosynthetic process
-is_a: GO:0050752 ! regulation of fractalkine biosynthetic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0050751 ! fractalkine biosynthetic process
-relationship: positively_regulates GO:0050751 ! fractalkine biosynthetic process
-
[Term]
id: GO:0050755
name: chemokine metabolic process
@@ -323771,7 +321636,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732]
synonym: "cocaine metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046448 ! tropane alkaloid metabolic process
@@ -323785,7 +321649,6 @@ synonym: "cocaine catabolism" EXACT []
synonym: "cocaine degradation" EXACT []
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
-is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0050783 ! cocaine metabolic process
@@ -323873,7 +321736,7 @@ namespace: biological_process
def: "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb]
synonym: "regulation of viral process" BROAD []
synonym: "regulation of viral reproduction" NARROW [GOC:bf, GOC:jl]
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0016032 ! viral process
relationship: regulates GO:0016032 ! viral process
@@ -324127,7 +321990,6 @@ synonym: "regulation of acyl-CoA synthesis" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0071616 ! acyl-CoA biosynthetic process
@@ -324456,8 +322318,6 @@ synonym: "S-adenosylmethionine breakdown" EXACT []
synonym: "S-adenosylmethionine catabolism" EXACT []
synonym: "S-adenosylmethionine degradation" EXACT []
synonym: "SAM catabolic process" EXACT []
-is_a: GO:0009109 ! coenzyme catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046500 ! S-adenosylmethionine metabolic process
is_a: GO:1901575 ! organic substance catabolic process
@@ -326472,6 +324332,7 @@ synonym: "squalene mutase (cyclizing)" EXACT [EC:5.4.99.17]
synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.17
xref: MetaCyc:5.4.99.17-RXN
+xref: RHEA:17637
is_a: GO:0016866 ! intramolecular transferase activity
is_a: GO:0034072 ! squalene cyclase activity
@@ -326488,6 +324349,7 @@ name: O-acetylhomoserine sulfhydrylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN, RHEA:27822]
xref: MetaCyc:ACETYLHOMOSER-CYS-RXN
+xref: RHEA:27822
is_a: GO:0016835 ! carbon-oxygen lyase activity
[Term]
@@ -326660,7 +324522,7 @@ namespace: biological_process
def: "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [PMID:23396135]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:1903046 ! meiotic cell cycle process
-relationship: part_of GO:0007129 ! synapsis
+relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis
relationship: part_of GO:0007131 ! reciprocal meiotic recombination
[Term]
@@ -327103,6 +324965,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN]
synonym: "ADP reduction" RELATED []
xref: MetaCyc:ADPREDUCT-RXN
+xref: RHEA:28034
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
[Term]
@@ -327112,6 +324975,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN]
synonym: "UDP reduction" RELATED []
xref: MetaCyc:UDPREDUCT-RXN
+xref: RHEA:28026
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
[Term]
@@ -327174,7 +325038,6 @@ synonym: "dihydrothioctamide metabolic process" EXACT []
synonym: "dihydrothioctamide metabolism" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
[Term]
@@ -327236,6 +325099,7 @@ synonym: "cobalamin-5'-phosphate synthase activity" EXACT [EC:2.7.8.26]
synonym: "CobS" RELATED [EC:2.7.8.26]
xref: EC:2.7.8.26
xref: MetaCyc:COBALAMINSYN-RXN
+xref: RHEA:16049
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
[Term]
@@ -327332,6 +325196,7 @@ synonym: "glycoprotein-specific chaperone activity" NARROW []
synonym: "histone-specific chaperone activity" NARROW []
synonym: "ribosomal chaperone activity" NARROW []
synonym: "tubulin-specific chaperone activity" NARROW []
+xref: Reactome:R-HSA-9683772 "Trimmed spike protein binds to calnexin"
is_a: GO:0005515 ! protein binding
[Term]
@@ -328627,75 +326492,71 @@ is_a: GO:0006810 ! transport
[Term]
id: GO:0051181
-name: cofactor transport
+name: obsolete cofactor transport
namespace: biological_process
-def: "The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
-subset: goslim_pir
+def: "OBSOLETE. The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "vitamin or cofactor transport" BROAD []
-is_a: GO:0006810 ! transport
+is_obsolete: true
[Term]
id: GO:0051182
-name: coenzyme transport
+name: obsolete coenzyme transport
namespace: biological_process
-def: "The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
-is_a: GO:0051181 ! cofactor transport
+def: "OBSOLETE. The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a coenzyme.
+is_obsolete: true
[Term]
id: GO:0051184
-name: cofactor transmembrane transporter activity
+name: obsolete cofactor transmembrane transporter activity
namespace: molecular_function
-def: "Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
+def: "OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "cofactor transporter activity" RELATED []
synonym: "vitamin or cofactor transporter activity" BROAD []
-is_a: GO:0022857 ! transmembrane transporter activity
-relationship: part_of GO:0051181 ! cofactor transport
+is_obsolete: true
[Term]
id: GO:0051185
-name: coenzyme transmembrane transporter activity
+name: obsolete coenzyme transmembrane transporter activity
namespace: molecular_function
-def: "Enables the transfer of a coenzyme from one side of a membrane to the other. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
+def: "OBSOLETE. Enables the transfer of a coenzyme from one side of a membrane to the other. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a coenzyme.
synonym: "coenzyme transporter activity" RELATED []
-is_a: GO:0051184 ! cofactor transmembrane transporter activity
-relationship: part_of GO:0051182 ! coenzyme transport
+is_obsolete: true
[Term]
id: GO:0051186
-name: cofactor metabolic process
+name: obsolete cofactor metabolic process
namespace: biological_process
-def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai]
-subset: goslim_chembl
-subset: goslim_drosophila
-subset: goslim_generic
-subset: goslim_pir
-subset: goslim_pombe
-subset: goslim_yeast
+def: "OBSOLETE. The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "cofactor metabolism" EXACT []
-is_a: GO:0044237 ! cellular metabolic process
+is_obsolete: true
[Term]
id: GO:0051187
-name: cofactor catabolic process
+name: obsolete cofactor catabolic process
namespace: biological_process
-def: "The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
+def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "cofactor breakdown" EXACT []
synonym: "cofactor catabolism" EXACT []
synonym: "cofactor degradation" EXACT []
-is_a: GO:0044248 ! cellular catabolic process
-is_a: GO:0051186 ! cofactor metabolic process
+is_obsolete: true
[Term]
id: GO:0051188
-name: cofactor biosynthetic process
+name: obsolete cofactor biosynthetic process
namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
+def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "cofactor anabolism" EXACT []
synonym: "cofactor biosynthesis" EXACT []
synonym: "cofactor formation" EXACT []
synonym: "cofactor synthesis" EXACT []
-is_a: GO:0044249 ! cellular biosynthetic process
-is_a: GO:0051186 ! cofactor metabolic process
+is_obsolete: true
[Term]
id: GO:0051189
@@ -328706,7 +326567,7 @@ subset: goslim_pir
synonym: "coenzyme and prosthetic group metabolic process" BROAD []
synonym: "coenzyme and prosthetic group metabolism" BROAD []
synonym: "prosthetic group metabolism" EXACT []
-is_a: GO:0051186 ! cofactor metabolic process
+is_a: GO:0008152 ! metabolic process
relationship: part_of GO:0044267 ! cellular protein metabolic process
[Term]
@@ -328719,7 +326580,7 @@ synonym: "coenzyme and prosthetic group catabolism" BROAD []
synonym: "prosthetic group breakdown" EXACT []
synonym: "prosthetic group catabolism" EXACT []
synonym: "prosthetic group degradation" EXACT []
-is_a: GO:0051187 ! cofactor catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:0051189 ! prosthetic group metabolic process
relationship: part_of GO:0044257 ! cellular protein catabolic process
@@ -328734,7 +326595,7 @@ synonym: "prosthetic group anabolism" EXACT []
synonym: "prosthetic group biosynthesis" EXACT []
synonym: "prosthetic group formation" EXACT []
synonym: "prosthetic group synthesis" EXACT []
-is_a: GO:0051188 ! cofactor biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:0051189 ! prosthetic group metabolic process
relationship: part_of GO:0009059 ! macromolecule biosynthetic process
@@ -328743,70 +326604,61 @@ id: GO:0051192
name: prosthetic group binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai, GOC:vw]
-is_a: GO:0048037 ! cofactor binding
+is_a: GO:0005488 ! binding
[Term]
id: GO:0051193
-name: regulation of cofactor metabolic process
+name: obsolete regulation of cofactor metabolic process
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
+def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "regulation of cofactor metabolism" EXACT []
-is_a: GO:0031323 ! regulation of cellular metabolic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0051186 ! cofactor metabolic process
-relationship: regulates GO:0051186 ! cofactor metabolic process
+is_obsolete: true
[Term]
id: GO:0051194
-name: positive regulation of cofactor metabolic process
+name: obsolete positive regulation of cofactor metabolic process
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
+def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "activation of cofactor metabolic process" NARROW []
synonym: "positive regulation of cofactor metabolism" EXACT []
synonym: "stimulation of cofactor metabolic process" NARROW []
synonym: "up regulation of cofactor metabolic process" EXACT []
synonym: "up-regulation of cofactor metabolic process" EXACT []
synonym: "upregulation of cofactor metabolic process" EXACT []
-is_a: GO:0031325 ! positive regulation of cellular metabolic process
-is_a: GO:0051193 ! regulation of cofactor metabolic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0051186 ! cofactor metabolic process
-relationship: positively_regulates GO:0051186 ! cofactor metabolic process
+is_obsolete: true
[Term]
id: GO:0051195
-name: negative regulation of cofactor metabolic process
+name: obsolete negative regulation of cofactor metabolic process
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
+def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor.
synonym: "down regulation of cofactor metabolic process" EXACT []
synonym: "down-regulation of cofactor metabolic process" EXACT []
synonym: "downregulation of cofactor metabolic process" EXACT []
synonym: "inhibition of cofactor metabolic process" NARROW []
synonym: "negative regulation of cofactor metabolism" EXACT []
-is_a: GO:0031324 ! negative regulation of cellular metabolic process
-is_a: GO:0051193 ! regulation of cofactor metabolic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0051186 ! cofactor metabolic process
-relationship: negatively_regulates GO:0051186 ! cofactor metabolic process
+is_obsolete: true
[Term]
id: GO:0051196
-name: regulation of coenzyme metabolic process
+name: obsolete regulation of coenzyme metabolic process
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
+def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "regulation of coenzyme metabolism" EXACT []
-is_a: GO:0051193 ! regulation of cofactor metabolic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0006732 ! coenzyme metabolic process
-relationship: regulates GO:0006732 ! coenzyme metabolic process
+is_obsolete: true
[Term]
id: GO:0051197
-name: positive regulation of coenzyme metabolic process
+name: obsolete positive regulation of coenzyme metabolic process
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
+def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "activation of coenzyme metabolic process" NARROW []
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD []
@@ -328815,17 +326667,14 @@ synonym: "stimulation of coenzyme metabolic process" NARROW []
synonym: "up regulation of coenzyme metabolic process" EXACT []
synonym: "up-regulation of coenzyme metabolic process" EXACT []
synonym: "upregulation of coenzyme metabolic process" EXACT []
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0006732 ! coenzyme metabolic process
-relationship: positively_regulates GO:0006732 ! coenzyme metabolic process
+is_obsolete: true
[Term]
id: GO:0051198
-name: negative regulation of coenzyme metabolic process
+name: obsolete negative regulation of coenzyme metabolic process
namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
+def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
+comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme.
synonym: "down regulation of coenzyme metabolic process" EXACT []
synonym: "down-regulation of coenzyme metabolic process" EXACT []
synonym: "downregulation of coenzyme metabolic process" EXACT []
@@ -328833,11 +326682,7 @@ synonym: "inhibition of coenzyme metabolic process" NARROW []
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "negative regulation of coenzyme metabolism" EXACT []
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0006732 ! coenzyme metabolic process
-relationship: negatively_regulates GO:0006732 ! coenzyme metabolic process
+is_obsolete: true
[Term]
id: GO:0051199
@@ -328848,7 +326693,6 @@ synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [
synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "regulation of prosthetic group metabolism" EXACT []
is_a: GO:0032268 ! regulation of cellular protein metabolic process
-is_a: GO:0051193 ! regulation of cofactor metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0051189 ! prosthetic group metabolic process
relationship: regulates GO:0051189 ! prosthetic group metabolic process
@@ -328867,7 +326711,6 @@ synonym: "up regulation of prosthetic group metabolic process" EXACT []
synonym: "up-regulation of prosthetic group metabolic process" EXACT []
synonym: "upregulation of prosthetic group metabolic process" EXACT []
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:0051199 ! regulation of prosthetic group metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0051189 ! prosthetic group metabolic process
@@ -328886,7 +326729,6 @@ synonym: "negative regulation of coenzyme and prosthetic group metabolic process
synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "negative regulation of prosthetic group metabolism" EXACT []
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:0051199 ! regulation of prosthetic group metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0051189 ! prosthetic group metabolic process
@@ -328899,7 +326741,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553]
synonym: "phytochromobilin metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
[Term]
id: GO:0051203
@@ -329959,7 +327800,6 @@ synonym: "NAD or NADH binding" RELATED [GOC:mah]
synonym: "NAD+ or NADH binding" RELATED []
synonym: "nicotinamide adenine dinucleotide binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
-is_a: GO:0050662 ! coenzyme binding
[Term]
id: GO:0051289
@@ -331010,7 +328850,6 @@ name: serotonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai]
synonym: "5-hydroxytryptamine binding" EXACT []
-is_a: GO:0042165 ! neurotransmitter binding
is_a: GO:0043169 ! cation binding
is_a: GO:0043176 ! amine binding
is_a: GO:0097159 ! organic cyclic compound binding
@@ -331037,7 +328876,6 @@ id: GO:0051381
name: histamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
-is_a: GO:0042165 ! neurotransmitter binding
is_a: GO:0043169 ! cation binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
@@ -331338,7 +329176,6 @@ synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8]
synonym: "clostridiopeptidase B activity" EXACT []
synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8]
synonym: "clostripain activity" EXACT []
-xref: EC:3.4.22.8
is_obsolete: true
replaced_by: GO:0004197
@@ -331371,7 +329208,6 @@ synonym: "metalloproteinase-1" RELATED [EC:3.4.24.3]
synonym: "microbial collagenase activity" EXACT []
synonym: "nucleolysin" RELATED [EC:3.4.24.3]
synonym: "soycollagestin" RELATED [EC:3.4.24.3]
-xref: EC:3.4.24.3
is_obsolete: true
replaced_by: GO:0004252
@@ -331453,7 +329289,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [ISBN:0721662544, PMID:11276391]
synonym: "response to cortisol stimulus" EXACT [GOC:dos]
synonym: "response to hydrocortisone stimulus" EXACT []
-is_a: GO:0042493 ! response to drug
is_a: GO:0051384 ! response to glucocorticoid
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
@@ -331580,7 +329415,6 @@ synonym: "corticotropin-releasing factor binding" EXACT []
synonym: "CRF binding" EXACT [GOC:bf]
synonym: "CRH binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding
-is_a: GO:0042165 ! neurotransmitter binding
[Term]
id: GO:0051425
@@ -332130,7 +329964,6 @@ name: regulation of cortisol secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai]
is_a: GO:2000849 ! regulation of glucocorticoid secretion
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0043400 ! cortisol secretion
relationship: regulates GO:0043400 ! cortisol secretion
@@ -332146,7 +329979,6 @@ synonym: "downregulation of cortisol secretion" EXACT []
synonym: "inhibition of cortisol secretion" NARROW []
is_a: GO:0051462 ! regulation of cortisol secretion
is_a: GO:2000850 ! negative regulation of glucocorticoid secretion
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0043400 ! cortisol secretion
relationship: negatively_regulates GO:0043400 ! cortisol secretion
@@ -332163,7 +329995,6 @@ synonym: "up-regulation of cortisol secretion" EXACT []
synonym: "upregulation of cortisol secretion" EXACT []
is_a: GO:0051462 ! regulation of cortisol secretion
is_a: GO:2000851 ! positive regulation of glucocorticoid secretion
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0043400 ! cortisol secretion
relationship: positively_regulates GO:0043400 ! cortisol secretion
@@ -332181,7 +330012,6 @@ synonym: "negative regulation of corticotropin-releasing factor secretion" EXACT
synonym: "negative regulation of CRF secretion" EXACT []
synonym: "negative regulation of CRH secretion" EXACT []
is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion
-is_a: GO:0051589 ! negative regulation of neurotransmitter transport
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion
@@ -332201,7 +330031,6 @@ synonym: "up regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "up-regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "upregulation of corticotropin-releasing hormone secretion" EXACT []
is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion
-is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion
@@ -332249,6 +330078,7 @@ namespace: biological_process
def: "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai]
synonym: "glucosylglycerol metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process
+is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019400 ! alditol metabolic process
[Term]
@@ -332260,6 +330090,7 @@ synonym: "glucosylglycerol anabolism" EXACT []
synonym: "glucosylglycerol biosynthesis" EXACT []
synonym: "glucosylglycerol formation" EXACT []
synonym: "glucosylglycerol synthesis" EXACT []
+is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0019401 ! alditol biosynthetic process
is_a: GO:0051472 ! glucosylglycerol metabolic process
@@ -332270,6 +330101,7 @@ namespace: molecular_function
def: "Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0015166 ! polyol transmembrane transporter activity
+is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity
relationship: part_of GO:0051475 ! glucosylglycerol transport
[Term]
@@ -332279,6 +330111,7 @@ namespace: biological_process
def: "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport
+is_a: GO:1901656 ! glycoside transport
[Term]
id: GO:0051476
@@ -332593,6 +330426,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667]
xref: EC:3.1.1.96
xref: MetaCyc:RXN-15041
+xref: RHEA:13953
is_a: GO:0002161 ! aminoacyl-tRNA editing activity
[Term]
@@ -332895,7 +330729,6 @@ synonym: "Fe/S binding" EXACT []
synonym: "iron sulfur cluster binding" EXACT []
synonym: "iron sulphur cluster binding" EXACT []
synonym: "iron-sulphur cluster binding" EXACT []
-is_a: GO:0048037 ! cofactor binding
is_a: GO:0051540 ! metal cluster binding
[Term]
@@ -333438,7 +331271,6 @@ synonym: "regulation of dopamine import involved in synaptic transmission" EXACT
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0043269 ! regulation of ion transport
is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission
relationship: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission
@@ -333456,7 +331288,6 @@ is_a: GO:0032227 ! negative regulation of synaptic transmission, dopaminergic
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission
is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission
relationship: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission
@@ -333476,7 +331307,6 @@ is_a: GO:0032226 ! positive regulation of synaptic transmission, dopaminergic
is_a: GO:0043270 ! positive regulation of ion transport
is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission
is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission
relationship: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission
@@ -333559,11 +331389,9 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:ai]
synonym: "cellular response to folate" EXACT [GOC:mah]
synonym: "cellular response to vitamin B9" EXACT [GOC:mah]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
-is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
[Term]
@@ -333718,7 +331546,6 @@ name: histamine transport
namespace: biological_process
def: "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0006812 ! cation transport
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
@@ -334034,9 +331861,7 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai]
synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0043269 ! regulation of ion transport
-is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:0051952 ! regulation of amine transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0051630 ! acetylcholine uptake
relationship: regulates GO:0051630 ! acetylcholine uptake
@@ -334051,10 +331876,8 @@ synonym: "down-regulation of acetylcholine uptake" EXACT []
synonym: "downregulation of acetylcholine uptake" EXACT []
synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0043271 ! negative regulation of ion transport
-is_a: GO:0051589 ! negative regulation of neurotransmitter transport
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051953 ! negative regulation of amine transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0051630 ! acetylcholine uptake
relationship: negatively_regulates GO:0051630 ! acetylcholine uptake
@@ -334071,10 +331894,8 @@ synonym: "up regulation of acetylcholine uptake" EXACT []
synonym: "up-regulation of acetylcholine uptake" EXACT []
synonym: "upregulation of acetylcholine uptake" EXACT []
is_a: GO:0043270 ! positive regulation of ion transport
-is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051954 ! positive regulation of amine transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0051630 ! acetylcholine uptake
relationship: positively_regulates GO:0051630 ! acetylcholine uptake
@@ -334790,6 +332611,7 @@ name: proline oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [MetaCyc:RXN-821]
xref: MetaCyc:RXN-821
+xref: RHEA:26124
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
[Term]
@@ -335070,7 +332892,6 @@ synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter a
synonym: "reduced NAD transporter activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
is_a: GO:0015215 ! nucleotide transmembrane transporter activity
-is_a: GO:0051185 ! coenzyme transmembrane transporter activity
relationship: part_of GO:0035352 ! NAD transmembrane transport
created_by: jl
creation_date: 2012-09-19T13:21:08Z
@@ -335215,6 +333036,7 @@ synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT []
synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphatase activity" EXACT [EC:2.7.1.78]
synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT []
xref: EC:2.7.1.78
+xref: RHEA:54580
is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity
[Term]
@@ -335266,7 +333088,6 @@ name: ethylene binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai]
synonym: "ethene binding" EXACT []
-is_a: GO:0042562 ! hormone binding
is_a: GO:0072328 ! alkene binding
[Term]
@@ -335276,6 +333097,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542]
synonym: "MPBQ methyltransferase activity" EXACT []
xref: MetaCyc:RXN-2542
+xref: RHEA:37979
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -335285,6 +333107,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762]
synonym: "MSBQ methyltransferase activity" EXACT []
xref: MetaCyc:RXN-2762
+xref: RHEA:37999
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
[Term]
@@ -335294,6 +333117,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence." [PMID:10743659]
synonym: "RCC reductase activity" EXACT []
xref: MetaCyc:RXN-7741
+xref: RHEA:24752
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
[Term]
@@ -335302,6 +333126,7 @@ name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72]
xref: MetaCyc:RXN1F-72
+xref: RHEA:48884
is_a: GO:0016491 ! oxidoreductase activity
[Term]
@@ -335347,6 +333172,7 @@ synonym: "UDP-sugar pyrophosphorylase activity" EXACT [EC:2.7.7.64]
synonym: "USP" RELATED [EC:2.7.7.64]
xref: EC:2.7.7.64
xref: MetaCyc:2.7.7.64-RXN
+xref: RHEA:13205
is_a: GO:0070569 ! uridylyltransferase activity
[Term]
@@ -335657,6 +333483,7 @@ comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reaction
synonym: "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [EC:1.14.13.79]
synonym: "ent-kaurenoic acid oxidase activity" EXACT []
xref: MetaCyc:1.14.13.79-RXN
+xref: RHEA:19241
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -335666,6 +333493,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160]
comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'.
xref: MetaCyc:RXN1F-160
+xref: RHEA:22904
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -335676,6 +333504,7 @@ def: "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gib
comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'.
synonym: "GA12-aldehyde oxidase activity" EXACT []
xref: MetaCyc:RXN1F-161
+xref: RHEA:22700
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -336175,7 +334004,7 @@ def: "Any process in which an organism modulates the frequency, rate or extent o
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction
relationship: regulates GO:0051838 ! cytolysis by host of symbiont cells
@@ -336403,6 +334232,7 @@ synonym: "protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase a
xref: EC:1.14.11.27
xref: MetaCyc:RXN-8660
xref: MetaCyc:RXN-8661
+xref: RHEA:42032
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
is_a: GO:0032452 ! histone demethylase activity
relationship: part_of GO:0070544 ! histone H3-K36 demethylation
@@ -336591,7 +334421,6 @@ namespace: biological_process
def: "Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
synonym: "killing of cells in other organism during symbiotic interaction" RELATED [GOC:tb]
is_a: GO:0031640 ! killing of cells of other organism
-is_a: GO:0044419 ! interspecies interaction between organisms
[Term]
id: GO:0051884
@@ -337336,10 +335165,8 @@ namespace: biological_process
def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah]
synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006835 ! dicarboxylic acid transport
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0015807 ! L-amino acid transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0043090 ! amino acid import
[Term]
@@ -338106,6 +335933,7 @@ synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT []
xref: EC:1.1.99.39
xref: Reactome:R-HSA-880007 "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2"
xref: Reactome:R-HSA-880053 "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]"
+xref: RHEA:38295
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
[Term]
@@ -338116,6 +335944,7 @@ def: "Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-d
comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227.
xref: EC:2.4.1.227
xref: MetaCyc:NACGLCTRANS-RXN
+xref: RHEA:31227
is_a: GO:0008375 ! acetylglucosaminyltransferase activity
created_by: ai
creation_date: 2010-07-06T11:53:19Z
@@ -338129,6 +335958,7 @@ comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-
subset: goslim_chembl
xref: EC:2.7.8.13
xref: MetaCyc:PHOSNACMURPENTATRANS-RXN
+xref: RHEA:28386
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
created_by: ai
creation_date: 2010-07-06T12:10:01Z
@@ -338141,6 +335971,7 @@ def: "Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic ac
synonym: "ABA-GE beta-glucosidase activity" EXACT []
xref: EC:3.2.1.175
xref: MetaCyc:RXN-11469
+xref: RHEA:31347
is_a: GO:0008422 ! beta-glucosidase activity
created_by: ai
creation_date: 2010-07-16T02:16:59Z
@@ -338186,6 +336017,7 @@ synonym: "4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxyl
synonym: "OHCU decarboxylase activity" EXACT []
xref: KEGG_REACTION:R06604
xref: MetaCyc:RXN-6201
+xref: RHEA:26301
is_a: GO:0016831 ! carboxy-lyase activity
created_by: ai
creation_date: 2010-07-19T10:47:15Z
@@ -338266,7 +336098,6 @@ is_a: GO:0044414 ! suppression of host defenses by symbiont
is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway
is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response
-is_a: GO:2001039 ! negative regulation of cellular response to drug
relationship: negatively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway
[Term]
@@ -339011,7 +336842,6 @@ is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0044416 ! induction by symbiont of host defense response
is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response
is_a: GO:1901672 ! positive regulation of systemic acquired resistance
-is_a: GO:2001040 ! positive regulation of cellular response to drug
relationship: positively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway
[Term]
@@ -341144,7 +338974,7 @@ synonym: "stimulation by organism of programmed cell death in other organism dur
synonym: "upregulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "upregulation by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT []
is_a: GO:0043068 ! positive regulation of programmed cell death
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
is_a: GO:0051712 ! positive regulation of killing of cells of other organism
is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction
relationship: positively_regulates GO:0051883 ! killing of cells in other organism involved in symbiotic interaction
@@ -341525,7 +339355,7 @@ synonym: "modulation by organism of entry into other organism during symbiotic i
synonym: "modulation by symbiont of entry into host" RELATED []
synonym: "regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb]
synonym: "regulation by organism of entry into other organism involved in symbiotic interaction" RELATED []
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044409 ! entry into host
relationship: regulates GO:0044409 ! entry into host
@@ -341609,6 +339439,7 @@ xref: EC:2.5.1.75
xref: MetaCyc:RXN0-6274
xref: Reactome:R-HSA-6784462 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs"
xref: Reactome:R-HSA-6787567 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser)"
+xref: RHEA:26482
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
creation_date: 2010-07-23T03:07:33Z
@@ -343318,6 +341149,7 @@ synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene
xref: EC:4.2.3.22
xref: KEGG_REACTION:R07648
xref: MetaCyc:RXN-8562
+xref: RHEA:12016
is_a: GO:0010334 ! sesquiterpene synthase activity
created_by: ai
creation_date: 2010-08-09T01:39:02Z
@@ -343329,6 +341161,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate." [MetaCyc:RXN-8574]
synonym: "(E,E)-alpha-farnesene synthase activity" EXACT [MetaCyc:RXN-8574]
xref: MetaCyc:RXN-8574
+xref: RHEA:27421
is_a: GO:0010334 ! sesquiterpene synthase activity
created_by: ai
creation_date: 2010-08-09T01:39:42Z
@@ -343481,6 +341314,7 @@ def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycer
comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591.
xref: EC:1.1.5.3
xref: MetaCyc:GLYC3PDEHYDROG-RXN
+xref: RHEA:28751
is_a: GO:0052590 ! sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity
[Term]
@@ -343510,6 +341344,7 @@ def: "Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 +
xref: EC:1.4.3.21
xref: KEGG_REACTION:R02529
xref: MetaCyc:AMACETOXID-RXN
+xref: RHEA:28186
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
[Term]
@@ -343581,6 +341416,7 @@ synonym: "trimethylenediamine oxidase activity" EXACT [CHEBI:15725]
xref: EC:1.4.3.22
xref: KEGG_REACTION:R03139
xref: MetaCyc:RXN-6381
+xref: RHEA:30895
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
[Term]
@@ -343624,6 +341460,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol." [MetaCyc:RXN-2561, PMID:12213958]
xref: KEGG_REACTION:R07503
xref: MetaCyc:RXN-2561
+xref: RHEA:37987
is_a: GO:0009975 ! cyclase activity
[Term]
@@ -343633,6 +341470,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol." [MetaCyc:RXN-2543, PMID:12213958]
xref: KEGG_REACTION:R07502
xref: MetaCyc:RXN-2543
+xref: RHEA:37983
is_a: GO:0009975 ! cyclase activity
[Term]
@@ -343700,6 +341538,7 @@ synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: EC:1.14.99
xref: MetaCyc:RXN-8026
+xref: RHEA:30327
is_a: GO:0004497 ! monooxygenase activity
[Term]
@@ -343712,6 +341551,7 @@ synonym: "beta-carotene hydroxylase activity" BROAD []
synonym: "carotene beta-ring hydroxylase activity" BROAD []
xref: EC:1.14.99
xref: MetaCyc:RXN-8025
+xref: RHEA:30323
is_a: GO:0004497 ! monooxygenase activity
[Term]
@@ -343745,6 +341585,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate." [MetaCyc:RXN0-6444, PMID:20369853, PMID:20400551]
synonym: "pyrimidine oxygenase activity" BROAD [MetaCyc:RXN0-6444]
xref: MetaCyc:RXN0-6444
+xref: RHEA:31587
is_a: GO:0016491 ! oxidoreductase activity
creation_date: 2010-08-26T10:11:11Z
@@ -343765,6 +341606,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al." [MetaCyc:RXN-5242]
xref: EC:1.14.14.86
xref: MetaCyc:RXN-5242
+xref: RHEA:21304
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -343774,6 +341616,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate." [MetaCyc:RXN-7580]
xref: EC:1.14.14.86
xref: MetaCyc:RXN-7580
+xref: RHEA:10928
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -343803,6 +341646,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2." [MetaCyc:RXN-8646]
xref: EC:1.17.99.4
xref: MetaCyc:RXN-8646
+xref: RHEA:13469
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups
[Term]
@@ -343911,8 +341755,8 @@ is_a: GO:0016881 ! acid-amino acid ligase activity
id: GO:0052629
name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [MetaCyc:RXN-10958, PMID:19901554]
-xref: EC:3.1.3
+def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [PMID:19901554, RHEA:39019]
+xref: EC:3.1.3.95
xref: MetaCyc:RXN-10958
xref: Reactome:R-HSA-1676065 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane"
xref: Reactome:R-HSA-1676105 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane"
@@ -343920,6 +341764,7 @@ xref: Reactome:R-HSA-1676203 "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs
xref: Reactome:R-HSA-6809320 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane"
xref: Reactome:R-HSA-6809778 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1"
xref: Reactome:R-HSA-6809944 "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane"
+xref: RHEA:39019
is_a: GO:0106018 ! phosphatidylinositol-3,5-bisphosphate phosphatase activity
[Term]
@@ -343947,6 +341792,7 @@ name: sphingolipid delta-8 desaturase activity
namespace: molecular_function
def: "Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8)." [PMID:17600137, PMID:9786850]
xref: MetaCyc:RXN-7798
+xref: RHEA:46268
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
[Term]
@@ -344013,7 +341859,7 @@ is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0052638
name: indole-3-butyrate beta-glucosyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP." [MetaCyc:RXN-11655]
+def: "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP." [MetaCyc:RXN-11655, RHEA:62708]
synonym: "IBA-Glc synthetase activity" EXACT []
synonym: "IBA-glucose synthase activity" EXACT []
synonym: "IBAGlu synthase activity" EXACT []
@@ -344026,32 +341872,35 @@ synonym: "UDPG-indol-3-ylbutyryl glucosyl transferase activity" EXACT []
synonym: "UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity" EXACT []
synonym: "uridine diphosphoglucose-indolebutyrate glucosyltransferase activity" EXACT []
xref: MetaCyc:RXN-11655
+xref: RHEA:62708
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
id: GO:0052639
name: salicylic acid glucosyltransferase (ester-forming) activity
namespace: molecular_function
-def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP." [MetaCyc:RXN-11659]
+def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP." [MetaCyc:RXN-11659, RHEA:62316]
synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11659]
synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
synonym: "UDP:glucose:SA glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
synonym: "UDP:glucose:salicylate glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
synonym: "UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659]
xref: MetaCyc:RXN-11659
+xref: RHEA:62316
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
id: GO:0052640
name: salicylic acid glucosyltransferase (glucoside-forming) activity
namespace: molecular_function
-def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP." [MetaCyc:RXN-11658]
+def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP." [MetaCyc:RXN-11658, RHEA:62312]
synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11658]
synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
synonym: "UDP:glucose:SA glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
synonym: "UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
synonym: "UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658]
xref: MetaCyc:RXN-11658
+xref: RHEA:62312
is_a: GO:0035251 ! UDP-glucosyltransferase activity
[Term]
@@ -344152,7 +342001,6 @@ synonym: "coenzyme F420 metabolism" EXACT [CHEBI:16848]
synonym: "coenzyme gamma-F420-2 metabolism" EXACT []
synonym: "F420-2 metabolic process" EXACT [CHEBI:16848]
synonym: "F420-2 metabolism" EXACT [CHEBI:16848]
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0052648 ! ribitol phosphate metabolic process
is_a: GO:0072350 ! tricarboxylic acid metabolic process
@@ -344221,7 +342069,6 @@ synonym: "cdiGMP metabolism" EXACT []
synonym: "cyclic diguanylate metabolic process" EXACT []
synonym: "cyclic diguanylate metabolism" EXACT []
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0052652 ! cyclic purine nucleotide metabolic process
created_by: ai
creation_date: 2010-09-23T11:16:56Z
@@ -344248,6 +342095,7 @@ synonym: "L-valine aminotransferase activity" EXACT []
xref: EC:2.6.1.42
xref: KEGG_REACTION:R01214
xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN
+xref: RHEA:24813
is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity
[Term]
@@ -344260,6 +342108,7 @@ synonym: "L-isoleucine aminotransferase activity" EXACT []
xref: EC:2.6.1.42
xref: KEGG_REACTION:R02199
xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN
+xref: RHEA:24801
is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity
[Term]
@@ -344282,6 +342131,7 @@ synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8]
xref: EC:2.4.2.8
xref: KEGG_REACTION:R01229
xref: MetaCyc:GUANPRIBOSYLTRAN-RXN
+xref: RHEA:25424
is_a: GO:0106130 ! purine phosphoribosyltransferase activity
[Term]
@@ -344377,14 +342227,13 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0052663
name: antheraxanthin epoxidase activity
namespace: molecular_function
-def: "Catalysis of the reaction: antheraxanthin + NAD(P)H + H+ + O2 = all-trans-violaxanthin + NAD(P)+ + H2O." [MetaCyc:RXN-7979]
+def: "Catalysis of the reaction: antheraxanthin + NAD(P)H + H+ + O2 = all-trans-violaxanthin + NAD(P)+ + H2O." [MetaCyc:RXN-7979, RHEA:14937]
synonym: "antheraxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90]
xref: EC:1.14.13.90
xref: KEGG_REACTION:R06947 "antheraxanthin,NADH:oxygen oxidoreductase activity"
xref: KEGG_REACTION:R07200 "antheraxanthin,NADPH:oxygen oxidoreductase activity"
xref: MetaCyc:RXN-7979
xref: RHEA:14937
-xref: RHEA:14944 "antheraxanthin,NADH:oxygen oxidoreductase activity"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -344473,6 +342322,7 @@ def: "Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-tr
synonym: "CTP:2-trans,-6-trans-farnesol phosphotransferase activity" EXACT []
xref: EC:2.7.1.216
xref: MetaCyc:RXN-11625
+xref: RHEA:51680
is_a: GO:0052668 ! farnesol kinase activity
created_by: ai
creation_date: 2011-04-11T01:32:05Z
@@ -344742,6 +342592,7 @@ xref: MetaCyc:CARBOXYLESTERASE-RXN
xref: Reactome:R-HSA-5693691 "CES1 trimer.CES2 hydrolyse COCN to BEG"
xref: Reactome:R-HSA-8937442 "CES3 hydrolyses CHEST to CHOL and LCFA(-)"
xref: Reactome:R-HSA-9619024 "CES1trimer hydrolyses ACEI pro-drugs to ACEIs"
+xref: RHEA:21164
xref: UM-BBD_reactionID:r1025
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds
@@ -344749,14 +342600,12 @@ is_a: GO:0016788 ! hydrolase activity, acting on ester bonds
id: GO:0052690
name: trichloro-p-hydroquinone reductive dehalogenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0031, UM-BBD_reactionID:r0315]
+def: "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl." [PMID:1459949, RHEA:56832, UM-BBD_reactionID:r0315]
synonym: "pentaerythritol tetranitrate reductase activity" RELATED [UM-BBD_enzymeID:e0028]
synonym: "tetrachlorohydroquinone reductive dehalogenase activity" RELATED [UM-BBD_enzymeID:e0251]
synonym: "trichlorohydroquinone reductive dehalogenase activity" EXACT []
synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028]
-xref: EC:1.6.99.1
-xref: EC:1.8.99
-xref: UM-BBD_reactionID:r0031
+xref: RHEA:56832
xref: UM-BBD_reactionID:r0315
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors
is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors
@@ -344804,6 +342653,7 @@ name: jasmonoyl-isoleucine-12-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O." [MetaCyc:RXN-12421, PMID:21576464]
xref: MetaCyc:RXN-12421
+xref: RHEA:54808
is_a: GO:0004497 ! monooxygenase activity
[Term]
@@ -344959,14 +342809,14 @@ creation_date: 2011-08-01T03:49:39Z
[Term]
id: GO:0052704
-name: ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine
+name: ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide
namespace: biological_process
-def: "The pathway resulting in the formation of ergothioneine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). N-alpha,N-alpha,N-alpha-trimethyl-L-histidine is modified by the ligation of gamma-glutamyl-cysteine and oxygen; this intermediate undergoes further modification by the removal of glutamate to produce hercynylcysteine sulfoxide. Finally, a beta-lyase acts on this compound, removing pyruvate, ammonia and oxygen to produce ergothioneine." [DOI:10.1021/ja101721e, EC:2.1.1.44, PMID:4276459, PMID:5484456, Wikipedia:Ergothioneine]
-is_a: GO:0006548 ! histidine catabolic process
+def: "The pathway resulting in the formation of ergothioneine from histidine via a set of steps in which gamma-glutamyl-hercynylcysteine sulfoxide is formed as an intermediate." [PMID:4276459, PMID:5484456]
+synonym: "ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine" BROAD []
+xref: Wikipedia:Ergothioneine
is_a: GO:0052699 ! ergothioneine biosynthetic process
-is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
relationship: has_part GO:0052707 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine
-relationship: has_part GO:0052711 ! ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/11163 xsd:anyURI
creation_date: 2011-08-05T11:31:52Z
[Term]
@@ -345078,17 +342928,18 @@ creation_date: 2011-08-05T02:22:54Z
[Term]
id: GO:0052711
-name: ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine
+name: obsolete ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine
namespace: biological_process
-def: "The pathway resulting in the formation of ergothioneine from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [KEGG_REACTION:R04878]
+def: "OBSOLETE. The pathway resulting in the formation of ergothioneine from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [KEGG_REACTION:R04878]
+comment: The reason for obsoletion is that this term does not provide a useful distinction from its parent, GO:0052704 (because that trimethyl-His yada is present in both pathways)
synonym: "ergothioneine biosynthesis from hercynine" EXACT []
synonym: "ergothioneine biosynthesis from histidine betaine" EXACT []
synonym: "hercynine catabolism to ergothioneine" EXACT []
synonym: "histidine betaine catabolism to ergothioneine" EXACT []
synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism to ergothioneine" EXACT []
xref: KEGG_REACTION:R04878
-is_a: GO:0052699 ! ergothioneine biosynthetic process
-is_a: GO:0052710 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/11163 xsd:anyURI
+is_obsolete: true
creation_date: 2011-08-05T04:06:16Z
[Term]
@@ -345138,6 +342989,7 @@ synonym: "p-diphenol:oxygen oxidoreductase activity" EXACT []
xref: EC:1.10.3.2
xref: KEGG_REACTION:R00083
xref: MetaCyc:LACCASE-RXN
+xref: RHEA:11276
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
created_by: ai
creation_date: 2011-08-11T03:18:19Z
@@ -345206,6 +343058,7 @@ name: fatty acid in-chain hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O." [MetaCyc:RXN-12186]
xref: MetaCyc:RXN-12186
+xref: RHEA:45084
is_a: GO:0004497 ! monooxygenase activity
created_by: ai
creation_date: 2011-08-15T01:41:07Z
@@ -345249,6 +343102,7 @@ xref: EC:2.7.1.159
xref: MetaCyc:2.7.1.133-RXN
xref: Reactome:R-HSA-1855197 "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol"
xref: Reactome:R-HSA-2267372 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4"
+xref: RHEA:20940
is_a: GO:0051766 ! inositol trisphosphate kinase activity
created_by: ai
creation_date: 2011-08-16T12:42:59Z
@@ -345270,6 +343124,7 @@ xref: KEGG_REACTION:R03428
xref: MetaCyc:2.7.1.139-RXN
xref: Reactome:R-HSA-1855172 "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol"
xref: Reactome:R-HSA-994140 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4"
+xref: RHEA:13253
is_a: GO:0051766 ! inositol trisphosphate kinase activity
created_by: ai
creation_date: 2011-08-16T12:43:11Z
@@ -345284,6 +343139,7 @@ synonym: "CCS" RELATED [EC:5.3.99.8]
synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8]
xref: EC:5.3.99.8
xref: MetaCyc:RXN-7947
+xref: RHEA:17373
is_a: GO:0016860 ! intramolecular oxidoreductase activity
created_by: ai
creation_date: 2011-08-16T03:09:21Z
@@ -345299,6 +343155,7 @@ synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8]
synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" EXACT [EC:5.3.99.8]
xref: EC:5.3.99.8
xref: MetaCyc:RXN-7946
+xref: RHEA:21752
is_a: GO:0016860 ! intramolecular oxidoreductase activity
created_by: ai
creation_date: 2011-08-16T03:09:26Z
@@ -345552,6 +343409,7 @@ synonym: "sinapyl-alcohol:NADP+ oxidoreductase activity" EXACT systematic_synony
xref: EC:1.1.1.195
xref: KEGG_REACTION:R03918
xref: MetaCyc:RXN-1125
+xref: RHEA:45704
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
creation_date: 2011-09-21T12:42:06Z
@@ -345595,6 +343453,7 @@ synonym: "versatile peroxidase activity" BROAD [EC:1.11.1.16]
xref: EC:1.11.1.16
xref: KEGG_REACTION:R07612
xref: MetaCyc:RXN-8666
+xref: RHEA:22396
is_a: GO:0004601 ! peroxidase activity
created_by: ai
creation_date: 2011-09-21T02:33:34Z
@@ -346436,7 +344295,6 @@ id: GO:0052825
name: inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate." [GOC:ai]
-xref: EC:3.1.3
xref: Reactome:R-HSA-1855219 "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol"
is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity
creation_date: 2011-11-29T09:49:22Z
@@ -346468,6 +344326,7 @@ name: inositol-3,4-bisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate." [GOC:mah]
xref: Reactome:R-HSA-1855202 "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol"
+xref: RHEA:43388
is_a: GO:0016312 ! inositol bisphosphate phosphatase activity
created_by: ai
creation_date: 2011-11-29T09:57:00Z
@@ -346477,7 +344336,6 @@ id: GO:0052829
name: inositol-1,3,4-trisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [GOC:ai]
-xref: EC:3.1.3
xref: Reactome:R-HSA-1855232 "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol"
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity
created_by: ai
@@ -346488,7 +344346,6 @@ id: GO:0052830
name: inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate." [GOC:ai]
-xref: EC:3.1.3
xref: Reactome:R-HSA-1855171 "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol"
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity
created_by: ai
@@ -346499,7 +344356,6 @@ id: GO:0052831
name: inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate." [GOC:ai]
-xref: EC:3.1.3
xref: Reactome:R-HSA-1855159 "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol"
is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity
created_by: ai
@@ -346513,6 +344369,7 @@ def: "Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol +
xref: EC:3.1.3.25
xref: MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN
xref: Reactome:R-HSA-1855210 "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol"
+xref: RHEA:30739
is_a: GO:0052834 ! inositol monophosphate phosphatase activity
created_by: ai
creation_date: 2011-11-29T11:00:09Z
@@ -346528,6 +344385,7 @@ synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD []
xref: EC:3.1.3.25
xref: MetaCyc:RXN-10952
xref: Reactome:R-HSA-1855211 "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol"
+xref: RHEA:30735
is_a: GO:0052834 ! inositol monophosphate phosphatase activity
created_by: ai
creation_date: 2011-11-29T11:02:15Z
@@ -346548,6 +344406,7 @@ synonym: "myo-inositol-phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25]
xref: EC:3.1.3.25
xref: MetaCyc:RXN-10949
+xref: RHEA:24056
is_a: GO:0052745 ! inositol phosphate phosphatase activity
created_by: ai
creation_date: 2011-11-29T11:15:58Z
@@ -346658,6 +344517,7 @@ xref: EC:3.6.1.52
xref: KEGG_REACTION:R05779
xref: Reactome:R-HSA-1855198 "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol"
xref: Reactome:R-HSA-2023971 "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol"
+xref: RHEA:22384
is_a: GO:0016462 ! pyrophosphatase activity
created_by: ai
creation_date: 2011-11-29T04:14:22Z
@@ -346978,15 +344838,14 @@ creation_date: 2011-12-13T01:20:17Z
id: GO:0052867
name: phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
-def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.-]
-synonym: "phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.-]
-synonym: "phosphatidylinositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.-]
-synonym: "phosphatidylinositol-trisphosphatase activity" BROAD [EC:3.1.3.-]
-synonym: "PtdIns(1,4,5)P(3) phosphatase activity" BROAD [EC:3.1.3.-]
-synonym: "PtdIns(1,4,5)P3 phosphatase activity" BROAD [EC:3.1.3.-]
-synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.-]
-synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.-]
-xref: EC:3.1.3
+def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate." [GOC:curators]
+synonym: "phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity" BROAD []
+synonym: "phosphatidylinositol 1,4,5-trisphosphate phosphatase activity" BROAD []
+synonym: "phosphatidylinositol-trisphosphatase activity" BROAD []
+synonym: "PtdIns(1,4,5)P(3) phosphatase activity" BROAD []
+synonym: "PtdIns(1,4,5)P3 phosphatase activity" BROAD []
+synonym: "triphosphoinositide phosphatase activity" BROAD []
+synonym: "triphosphoinositide phosphomonoesterase activity" BROAD []
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity
is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity
creation_date: 2012-01-11T12:07:50Z
@@ -347350,6 +345209,7 @@ synonym: "oxynitrilase activity" BROAD [EC:4.1.2.47]
xref: EC:4.1.2.47
xref: KEGG_REACTION:R09359
xref: MetaCyc:RXN-11732
+xref: RHEA:54660
is_a: GO:0016832 ! aldehyde-lyase activity
[Term]
@@ -347360,6 +345220,7 @@ def: "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetami
synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14]
xref: EC:1.5.3.14
xref: MetaCyc:RXN-10465
+xref: RHEA:25996
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
[Term]
@@ -347520,6 +345381,7 @@ synonym: "tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity" EXACT [EC:2.1.1.22
synonym: "tRNA(m(1)G(9)/m(1)A(9))Mtase activity" EXACT [EC:2.1.1.221]
xref: EC:2.1.1.221
xref: MetaCyc:RXN-12459
+xref: RHEA:43156
is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity
[Term]
@@ -347532,6 +345394,7 @@ synonym: "tRNA (m(1)G(37)) methyltransferase activity" EXACT [EC:2.1.1.228]
synonym: "tRNA-(N(1)G37) methyltransferase activity" EXACT [EC:2.1.1.228]
xref: EC:2.1.1.228
xref: MetaCyc:RXN-12458
+xref: RHEA:36899
is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity
[Term]
@@ -347544,6 +345407,7 @@ synonym: "rRNA large subunit methyltransferase F activity" RELATED [EC:2.1.1.181
xref: EC:2.1.1.181
xref: KEGG_REACTION:R07232
xref: MetaCyc:RXN-11596
+xref: RHEA:16497
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity
[Term]
@@ -347554,6 +345418,7 @@ def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adeni
synonym: "S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity" EXACT [EC:2.1.1.182]
xref: EC:2.1.1.182
xref: MetaCyc:RXN-11633
+xref: RHEA:19609
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity
[Term]
@@ -347564,6 +345429,7 @@ def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adeni
synonym: "M(6)(2)A dimethylase activity" BROAD [EC:2.1.1.183]
xref: EC:2.1.1.183
xref: MetaCyc:RXN-11634
+xref: RHEA:42780
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity
[Term]
@@ -347576,6 +345442,7 @@ synonym: "rRNA methyltransferase ermC' activity" RELATED [EC:2.1.1.184]
synonym: "rRNA:m(6)A methyltransferase ermC' activity" RELATED [EC:2.1.1.184]
xref: EC:2.1.1.184
xref: MetaCyc:RXN-11597
+xref: RHEA:42784
is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity
[Term]
@@ -347615,6 +345482,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S
xref: EC:2.1.1.171
xref: KEGG_REACTION:R07234
xref: MetaCyc:RXN0-6515
+xref: RHEA:23548
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity
[Term]
@@ -347626,6 +345494,7 @@ synonym: "M(2)G1207 methyltransferase activity" EXACT [EC:2.1.1.172]
xref: EC:2.1.1.172
xref: KEGG_REACTION:R07234
xref: MetaCyc:RXN-11576
+xref: RHEA:42736
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity
[Term]
@@ -347636,6 +345505,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23
xref: EC:2.1.1.173
xref: KEGG_REACTION:R07234
xref: MetaCyc:RXN-11574
+xref: RHEA:42740
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity
[Term]
@@ -347646,6 +345516,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23
xref: EC:2.1.1.174
xref: KEGG_REACTION:R07234
xref: MetaCyc:RXN-11635
+xref: RHEA:42744
is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity
[Term]
@@ -347702,6 +345573,7 @@ def: "Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + aceton
xref: EC:4.1.2.46
xref: KEGG_REACTION:R01553
xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN
+xref: RHEA:11932
is_a: GO:0052919 ! aliphatic (R)-hydroxynitrile lyase activity
[Term]
@@ -347816,6 +345688,7 @@ synonym: "methanol dehydrogenase activity" BROAD [EC:1.1.2.7]
xref: EC:1.1.2.7
xref: KEGG_REACTION:R01146
xref: MetaCyc:RXN-2861
+xref: RHEA:51008
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
[Term]
@@ -347848,6 +345721,7 @@ def: "Catalysis of the reaction: primary alcohol + 2 cytochrome c(L) = 2 reduced
synonym: "alcohol:cytochrome c(L) oxidoreductase activity" EXACT systematic_synonym [EC:1.1.2.7]
xref: EC:1.1.2.7
xref: MetaCyc:RXN-11332
+xref: RHEA:51004
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
[Term]
@@ -349063,7 +346937,6 @@ namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd]
synonym: "pyrrolidine-2-carboxylic acid biosynthetic process" BROAD []
is_a: GO:0006561 ! proline biosynthetic process
-is_a: GO:0017144 ! drug metabolic process
created_by: jid
creation_date: 2009-10-22T01:59:56Z
@@ -349909,7 +347782,7 @@ is_a: GO:0007623 ! circadian rhythm
[Term]
id: GO:0060087
-name: relaxation of vascular smooth muscle
+name: relaxation of vascular associated smooth muscle
namespace: biological_process
alt_id: GO:1905657
alt_id: GO:1905658
@@ -349918,6 +347791,7 @@ def: "A negative regulation of smooth muscle contraction resulting in relaxation
synonym: "negative regulation of relaxation of vascular smooth muscle" RELATED []
synonym: "positive regulation of relaxation of vascular smooth muscle" RELATED []
synonym: "regulation of relaxation of vascular smooth muscle" RELATED []
+synonym: "relaxation of vascular smooth muscle" EXACT []
synonym: "vascular smooth muscle relaxation" EXACT []
is_a: GO:0044557 ! relaxation of smooth muscle
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
@@ -349953,7 +347827,8 @@ subset: goslim_pir
synonym: "binding, bridging" EXACT []
synonym: "protein complex scaffold activity" RELATED []
synonym: "protein-containing complex scaffold activity" RELATED []
-is_a: GO:0005488 ! binding
+is_a: GO:0003674 ! molecular_function
+relationship: has_part GO:0005488 ! binding
[Term]
id: GO:0060091
@@ -350547,7 +348422,7 @@ id: GO:0060147
name: regulation of posttranscriptional gene silencing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
-is_a: GO:0010468 ! regulation of gene expression
+is_a: GO:0060968 ! regulation of gene silencing
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0016441 ! posttranscriptional gene silencing
relationship: regulates GO:0016441 ! posttranscriptional gene silencing
@@ -350557,7 +348432,7 @@ id: GO:0060148
name: positive regulation of posttranscriptional gene silencing
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
-is_a: GO:0048518 ! positive regulation of biological process
+is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0016441 ! posttranscriptional gene silencing
@@ -350568,8 +348443,8 @@ id: GO:0060149
name: negative regulation of posttranscriptional gene silencing
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
-is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
+is_a: GO:0060969 ! negative regulation of gene silencing
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0016441 ! posttranscriptional gene silencing
relationship: negatively_regulates GO:0016441 ! posttranscriptional gene silencing
@@ -350668,7 +348543,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
-is_a: GO:2001038 ! regulation of cellular response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0007212 ! dopamine receptor signaling pathway
relationship: regulates GO:0007212 ! dopamine receptor signaling pathway
@@ -350681,7 +348555,6 @@ def: "Any process that stops, prevents, or reduces the frequency, rate or extent
synonym: "negative regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
-is_a: GO:2001039 ! negative regulation of cellular response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway
relationship: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway
@@ -350694,7 +348567,6 @@ def: "Any process that activates or increases the frequency, rate or extent of t
synonym: "positive regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
-is_a: GO:2001040 ! positive regulation of cellular response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0007212 ! dopamine receptor signaling pathway
relationship: positively_regulates GO:0007212 ! dopamine receptor signaling pathway
@@ -352481,7 +350353,7 @@ relationship: positively_regulates GO:0034341 ! response to interferon-gamma
id: GO:0060333
name: interferon-gamma-mediated signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:dph, GOC:signaling, PR:000000017]
+def: "A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:dph, GOC:signaling]
synonym: "gamma-interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "immune interferon signaling pathway" EXACT [GOC:dph]
synonym: "interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
@@ -352544,7 +350416,7 @@ relationship: negatively_regulates GO:0060333 ! interferon-gamma-mediated signal
id: GO:0060337
name: type I interferon signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph, GOC:signaling, PR:000025848]
+def: "A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph, GOC:signaling]
synonym: "type I interferon-activated signaling pathway" EXACT [GOC:signaling]
synonym: "type I interferon-mediated signaling pathway" RELATED [GOC:signaling]
synonym: "type I interferon-mediated signalling pathway" EXACT [GOC:mah]
@@ -352768,7 +350640,9 @@ relationship: negatively_regulates GO:1903801 ! L-leucine import across plasma m
id: GO:0060359
name: response to ammonium ion
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:dph, GOC:tb]
+alt_id: GO:1903717
+def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267]
+synonym: "response to ammonia" EXACT []
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901698 ! response to nitrogen compound
@@ -353262,7 +351136,6 @@ name: regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0001505 ! regulation of neurotransmitter levels
-is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -353274,7 +351147,6 @@ id: GO:0060409
name: positive regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
-is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -353286,7 +351158,6 @@ id: GO:0060410
name: negative regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
-is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -353400,6 +351271,7 @@ id: GO:0060422
name: peptidyl-dipeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain." [GOC:dph, GOC:tb]
+xref: Wikipedia:ACE_inhibitor
is_a: GO:0030414 ! peptidase inhibitor activity
[Term]
@@ -354775,7 +352647,6 @@ name: regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032768 ! regulation of monooxygenase activity
-is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0060556 ! regulation of vitamin D biosynthetic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -354790,7 +352661,6 @@ name: positive regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032770 ! positive regulation of monooxygenase activity
-is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0060557 ! positive regulation of vitamin D biosynthetic process
is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
@@ -359334,7 +357204,7 @@ namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
-is_a: GO:0035886 ! vascular smooth muscle cell differentiation
+is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation
relationship: part_of GO:0060976 ! coronary vasculature development
created_by: dph
creation_date: 2009-09-29T02:56:08Z
@@ -359346,7 +357216,7 @@ namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell development" EXACT [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
-is_a: GO:0097084 ! vascular smooth muscle cell development
+is_a: GO:0097084 ! vascular associated smooth muscle cell development
relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation
created_by: dph
creation_date: 2009-09-29T03:00:24Z
@@ -359358,7 +357228,7 @@ namespace: biological_process
def: "The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
-is_a: GO:0097081 ! vascular smooth muscle cell fate commitment
+is_a: GO:0097081 ! vascular associated smooth muscle cell fate commitment
relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation
created_by: dph
creation_date: 2009-09-29T03:02:45Z
@@ -364155,8 +362025,8 @@ id: GO:0061370
name: testosterone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5." [GOC:dph, GOC:yaf]
+is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
-is_a: GO:0120178 ! steroid hormone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
created_by: dph
creation_date: 2010-10-27T02:50:48Z
@@ -364378,21 +362248,23 @@ creation_date: 2011-07-14T10:25:55Z
[Term]
id: GO:0061392
-name: regulation of transcription from RNA polymerase II promoter in response to osmotic stress
+name: obsolete regulation of transcription from RNA polymerase II promoter in response to osmotic stress
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577]
-is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress
-is_a: GO:0071470 ! cellular response to osmotic stress
+def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577]
+comment: This term was obsoleted because it represents a GO-CAM model.
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI
+is_obsolete: true
created_by: dph
creation_date: 2011-12-13T08:52:04Z
[Term]
id: GO:0061393
-name: positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
+name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
namespace: biological_process
-def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577]
-is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress
-is_a: GO:0061392 ! regulation of transcription from RNA polymerase II promoter in response to osmotic stress
+def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577]
+comment: This term was obsoleted because it represents a GO-CAM model.
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI
+is_obsolete: true
created_by: dph
creation_date: 2011-12-13T08:58:20Z
@@ -364469,11 +362341,12 @@ creation_date: 2012-01-10T09:36:02Z
[Term]
id: GO:0061401
-name: positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment
+name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment
namespace: biological_process
-def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph]
-is_a: GO:0061393 ! positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
-is_a: GO:0071476 ! cellular hypotonic response
+def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph]
+comment: This term was obsoleted because it represents a GO-CAM model.
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI
+is_obsolete: true
created_by: dph
creation_date: 2012-01-10T09:43:08Z
@@ -364500,11 +362373,12 @@ creation_date: 2012-01-10T03:15:30Z
[Term]
id: GO:0061404
-name: positive regulation of transcription from RNA polymerase II promoter in response to increased salt
+name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to increased salt
namespace: biological_process
-def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph]
-is_a: GO:0036251 ! positive regulation of transcription from RNA polymerase II promoter in response to salt stress
-is_a: GO:0071475 ! cellular hyperosmotic salinity response
+def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph]
+comment: This term was obsoleted because it represents a GO-CAM model.
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI
+is_obsolete: true
created_by: dph
creation_date: 2012-01-10T03:20:40Z
@@ -364620,11 +362494,12 @@ creation_date: 2012-01-23T11:33:08Z
[Term]
id: GO:0061416
-name: regulation of transcription from RNA polymerase II promoter in response to salt stress
+name: obsolete regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph, PMID:18667581]
-is_a: GO:0061392 ! regulation of transcription from RNA polymerase II promoter in response to osmotic stress
-is_a: GO:0071472 ! cellular response to salt stress
+def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph, PMID:18667581]
+comment: This term was obsoleted because it represents a GO-CAM model.
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI
+is_obsolete: true
created_by: dph
creation_date: 2012-01-23T12:56:36Z
@@ -365340,7 +363215,7 @@ creation_date: 2012-12-06T15:23:15Z
id: GO:0061493
name: central plaque of mitotic spindle pole body
namespace: cellular_component
-def: "One of three laminate structures that form the mitotic spindle pole body; the central plaque is embedded in the nuclear envelope." [GOC:dph]
+def: "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body." [GOC:dph]
is_a: GO:0005823 ! central plaque of spindle pole body
relationship: part_of GO:0044732 ! mitotic spindle pole body
created_by: dph
@@ -365429,6 +363304,7 @@ name: cyclic-GMP-AMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP." [GOC:dph, PMID:23258413]
xref: Reactome:R-HSA-3244614 "cGAS produces cyclic GMP-AMP"
+xref: RHEA:35647
is_a: GO:0016779 ! nucleotidyltransferase activity
created_by: dph
creation_date: 2013-01-04T07:17:57Z
@@ -365698,7 +363574,6 @@ def: "The regulated release of aspartate by a cell." [GOC:dph]
is_a: GO:0015740 ! C4-dicarboxylate transport
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0032940 ! secretion by cell
-is_a: GO:0046717 ! acid secretion
created_by: dph
creation_date: 2013-06-21T15:45:37Z
@@ -365783,7 +363658,6 @@ namespace: biological_process
def: "The controlled release of glycine by a cell." [GOC:dph]
is_a: GO:0015816 ! glycine transport
is_a: GO:0032940 ! secretion by cell
-is_a: GO:0046717 ! acid secretion
created_by: dph
creation_date: 2013-06-21T16:18:23Z
@@ -365813,7 +363687,6 @@ id: GO:0061539
name: octopamine secretion
namespace: biological_process
def: "The controlled release of octopamine by a cell." [GOC:dph]
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0032940 ! secretion by cell
@@ -365880,7 +363753,6 @@ id: GO:0061545
name: tyramine secretion
namespace: biological_process
def: "The regulated release of a tyramine by a cell." [GOC:dph]
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport
is_a: GO:0061531 ! primary amine secretion
@@ -366254,6 +364126,7 @@ namespace: molecular_function
def: "Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone." [GOC:dph]
synonym: "autoinducer-1 synthase" RELATED [GOC:dph]
xref: EC:2.3.1.184
+xref: RHEA:10096
is_a: GO:0016410 ! N-acyltransferase activity
created_by: dph
creation_date: 2013-11-15T19:48:23Z
@@ -366403,6 +364276,7 @@ namespace: molecular_function
def: "Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP." [PMID:24463506]
xref: EC:2.7.1.184
xref: MetaCyc:RXN-15297
+xref: RHEA:40443
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
created_by: dph
creation_date: 2014-02-10T09:59:26Z
@@ -366423,6 +364297,7 @@ namespace: molecular_function
def: "Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+." [EC:1.1.1.373, GOC:dph, PMID:24463506]
xref: EC:1.1.1.373
xref: MetaCyc:RXN-15299
+xref: RHEA:40511
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
created_by: dph
creation_date: 2014-02-10T10:09:43Z
@@ -366455,6 +364330,7 @@ namespace: molecular_function
def: "Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP." [EC:2.10.1.1, GOC:dph]
xref: EC:2.10.1.1
xref: Reactome:R-HSA-947531 "Molybdenum ion transfer onto molybdopterin"
+xref: RHEA:35047
is_a: GO:0016740 ! transferase activity
created_by: dph
creation_date: 2014-02-10T14:30:31Z
@@ -366465,6 +364341,7 @@ name: molybdenum cofactor cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor." [EC:2.7.7.76, GOC:dph]
xref: EC:2.7.7.76
+xref: RHEA:31335
is_a: GO:0070567 ! cytidylyltransferase activity
created_by: dph
creation_date: 2014-02-10T14:46:38Z
@@ -366475,6 +364352,7 @@ name: molybdenum cofactor guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor." [EC:2.7.7.77, GOC:dph]
xref: EC:2.7.7.77
+xref: RHEA:34243
is_a: GO:0070568 ! guanylyltransferase activity
created_by: dph
creation_date: 2014-02-10T14:54:36Z
@@ -366485,6 +364363,7 @@ name: molybdopterin-synthase sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase." [EC:2.8.1.11, GOC:dph, PMID:18154309, PMID:22370186]
xref: EC:2.8.1.11
+xref: RHEA:48612
is_a: GO:0016783 ! sulfurtransferase activity
created_by: dph
creation_date: 2014-02-11T11:56:16Z
@@ -366495,6 +364374,7 @@ name: molybdopterin-synthase adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP." [EC:2.7.7.80, GOC:dph, PMID:18154309, PMID:22370186]
xref: EC:2.7.7.80
+xref: RHEA:43616
is_a: GO:0070566 ! adenylyltransferase activity
created_by: dph
creation_date: 2014-02-11T12:01:32Z
@@ -366886,6 +364766,7 @@ xref: Reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL"
xref: Reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation"
xref: Reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216"
xref: Reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4"
+xref: Reactome:R-HSA-9686969 "APC/C:Cdh1 polyubiquitinates SKP2"
xref: Reactome:R-HSA-990526 "Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1"
is_a: GO:0004842 ! ubiquitin-protein transferase activity
is_a: GO:0061659 ! ubiquitin-like protein ligase activity
@@ -367478,12 +365359,16 @@ creation_date: 2015-03-04T16:00:21Z
[Term]
id: GO:0061686
-name: hercynylcysteine sulfoxide synthase
+name: hercynylcysteine sulfoxide synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine + O2 <=> hercynylcysteine sulfoxide + H2O." [GOC:dph, PMID:28577]
+def: "Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 <=> hercynylcysteine sulfoxide + H2O." [GOC:dph, PMID:24828577, PMID:4276459, RHEA:42704]
synonym: "hercynylcysteine S-oxide synthase" EXACT [GOC:dph]
+synonym: "hercynylcysteine sulfoxide synthase" EXACT []
+xref: EC:1.14.99.51
+xref: RHEA:42704
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
-relationship: part_of GO:0052699 ! ergothioneine biosynthetic process
+relationship: part_of GO:0140479 ! ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/11163 xsd:anyURI
created_by: dph
creation_date: 2015-03-06T15:08:51Z
@@ -367708,6 +365593,7 @@ namespace: molecular_function
def: "Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+." [GOC:dph, PMID:15509579]
xref: MetaCyc:RXN-16821
xref: Reactome:R-HSA-6787447 "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA"
+xref: RHEA:47040
is_a: GO:0016783 ! sulfurtransferase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
created_by: dph
@@ -368681,6 +366567,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate." [GOC:dph, GOC:ik, PMID:25896388]
xref: EC:4.1.99.22
xref: MetaCyc:RXN-8340
+xref: RHEA:49576
is_a: GO:0016830 ! carbon-carbon lyase activity
created_by: dph
creation_date: 2016-10-06T14:26:11Z
@@ -368692,6 +366579,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate." [GOC:dph, GOC:ik, PMID:25896388]
xref: EC:4.6.1.17
xref: MetaCyc:RXN-17809
+xref: RHEA:49580
is_a: GO:0016849 ! phosphorus-oxygen lyase activity
created_by: dph
creation_date: 2016-10-06T14:36:56Z
@@ -368820,6 +366708,7 @@ name: NAD glycohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528]
xref: EC:3.2.2.5
+xref: Reactome:R-HSA-9637699 "CpnT hydrolyses NAD+"
is_a: GO:0003953 ! NAD+ nucleosidase activity
created_by: dph
creation_date: 2016-11-11T13:18:54Z
@@ -369950,6 +367839,7 @@ name: glutathione specific gamma-glutamylcyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine." [PMID:23070364, PMID:27913623]
xref: EC:4.3.2.7
+xref: RHEA:47724
is_a: GO:0016842 ! amidine-lyase activity
created_by: dph
creation_date: 2017-08-29T14:55:30Z
@@ -369960,6 +367850,7 @@ name: gamma-glutamylaminecyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline." [PMID:20110353, PMID:6107907]
xref: EC:4.3.2.8
+xref: RHEA:16961
is_a: GO:0016842 ! amidine-lyase activity
created_by: dph
creation_date: 2017-08-29T14:57:39Z
@@ -370256,8 +368147,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an (R)-carnitine stimulus." [PMID:28102299]
synonym: "response to L-carnitine" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
-is_a: GO:0033273 ! response to vitamin
-is_a: GO:0042493 ! response to drug
created_by: dph
creation_date: 2018-01-19T13:31:39Z
@@ -370570,6 +368459,7 @@ name: beta-ketodecanoyl-[acyl-carrier-protein] synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2." [EC:2.3.1.207, PMID:22753057]
xref: MetaCyc:RXN-13613
+xref: RHEA:42264
is_a: GO:0016415 ! octanoyltransferase activity
created_by: dph
creation_date: 2018-02-15T22:29:03Z
@@ -371429,7 +369319,7 @@ id: GO:0062086
name: regulation of vein smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203]
-is_a: GO:0003056 ! regulation of vascular smooth muscle contraction
+is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0014826 ! vein smooth muscle contraction
relationship: regulates GO:0014826 ! vein smooth muscle contraction
@@ -371442,7 +369332,7 @@ name: positive regulation of vein smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203]
is_a: GO:0062086 ! regulation of vein smooth muscle contraction
-is_a: GO:1904695 ! positive regulation of vascular smooth muscle contraction
+is_a: GO:1904695 ! positive regulation of vascular associated smooth muscle contraction
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0014826 ! vein smooth muscle contraction
relationship: positively_regulates GO:0014826 ! vein smooth muscle contraction
@@ -371455,7 +369345,7 @@ name: negative regulation of vein smooth muscle contraction
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203]
is_a: GO:0062086 ! regulation of vein smooth muscle contraction
-is_a: GO:1904694 ! negative regulation of vascular smooth muscle contraction
+is_a: GO:1904694 ! negative regulation of vascular associated smooth muscle contraction
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0014826 ! vein smooth muscle contraction
relationship: negatively_regulates GO:0014826 ! vein smooth muscle contraction
@@ -371469,7 +369359,6 @@ namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
-is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -371484,7 +369373,6 @@ name: positive regulation of taurine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
-is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
@@ -371999,8 +369887,8 @@ id: GO:0062142
name: L-beta-ethynylserine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-beta-ethynylserine. L-beta-ethynylserine is an antibiotic produced by Streptomyces bacteria." [PMID:3082841, PMID:30867596]
-is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0043453 ! alkyne biosynthetic process
+is_a: GO:1901607 ! alpha-amino acid biosynthetic process
created_by: dph
creation_date: 2019-09-02T16:39:59Z
@@ -372009,8 +369897,8 @@ id: GO:0062143
name: L-propargylglycine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-propargylglycine (Pra). L-propargylglycine is an antibiotic produced by Streptomyces bacteria." [PMID:30867596]
-is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0043453 ! alkyne biosynthetic process
+is_a: GO:1901607 ! alpha-amino acid biosynthetic process
created_by: dph
creation_date: 2019-09-02T16:45:12Z
@@ -372198,7 +370086,6 @@ def: "Any process that modulates the frequency, rate or extent of a pyocyanine b
synonym: "regulation of pyocyanin biosynthetic process" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
-is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0106220 ! pyocyanine biosynthetic process
relationship: regulates GO:0106220 ! pyocyanine biosynthetic process
@@ -372214,7 +370101,6 @@ synonym: "positive regulation of pyocyanin biosynthetic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0062161 ! regulation of pyocyanine biosynthetic process
-is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0106220 ! pyocyanine biosynthetic process
relationship: positively_regulates GO:0106220 ! pyocyanine biosynthetic process
@@ -372358,7 +370244,6 @@ synonym: "allotetrahydroprogesterone metabolic process" EXACT []
synonym: "allotetrahydroprogesterone metabolism" EXACT []
synonym: "brexanolone metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: dph
@@ -372405,7 +370290,6 @@ synonym: "brexanolone catabolism" EXACT []
synonym: "brexanolone degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042182 ! ketone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0062173 ! brexanolone metabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
created_by: dph
@@ -372935,7 +370819,7 @@ namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of platelet activating factor, 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine." [PMID:16371369]
synonym: "2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine catabolic process" EXACT []
synonym: "PAF catabolic process" RELATED []
-is_a: GO:0042737 ! drug catabolic process
+is_a: GO:0044269 ! glycerol ether catabolic process
is_a: GO:0046469 ! platelet activating factor metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
@@ -372989,6 +370873,9 @@ id: GO:0062239
name: heterochromatin-nuclear membrane anchor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization." [PMID:31635174]
+synonym: "heterochromatin-nuclear membrane tether activity" EXACT []
+synonym: "nuclear membrane-heterochromatin anchor activity" EXACT []
+synonym: "nuclear membrane-heterochromatin tether activity" EXACT []
is_a: GO:0043495 ! protein-membrane adaptor activity
created_by: dph
creation_date: 2020-04-20T18:20:36Z
@@ -372998,6 +370885,9 @@ id: GO:0062240
name: euchromatin-nuclear membrane anchor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization." [PMID:31635174]
+synonym: "euchromatin-nuclear membrane tether activity" EXACT []
+synonym: "nuclear membrane-euchromatin anchor activity" EXACT []
+synonym: "nuclear membrane-euchromatin tether activity" EXACT []
is_a: GO:0043495 ! protein-membrane adaptor activity
created_by: dph
creation_date: 2020-04-20T18:22:35Z
@@ -373080,6 +370970,17 @@ relationship: part_of GO:0009507 ! chloroplast
created_by: dph
creation_date: 2020-05-01T12:10:16Z
+[Term]
+id: GO:0062248
+name: cleistothecium formation
+namespace: biological_process
+def: "The process of producing a cleistothecium, a closed sexual fruiting body that contains ascospores in linear asci. Cleistothecia are present in some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [PMID:20348388, PMID:28889020, PMID:30410052]
+is_a: GO:0003006 ! developmental process involved in reproduction
+is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
+relationship: part_of GO:0070791 ! cleistothecium development
+created_by: dph
+creation_date: 2020-05-08T16:14:06Z
+
[Term]
id: GO:0065001
name: specification of axis polarity
@@ -373184,21 +371085,21 @@ id: GO:0070001
name: aspartic-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
-is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides
+is_a: GO:0008233 ! peptidase activity
[Term]
id: GO:0070002
name: glutamic-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
-is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides
+is_a: GO:0008233 ! peptidase activity
[Term]
id: GO:0070003
name: threonine-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]
-is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides
+is_a: GO:0008233 ! peptidase activity
[Term]
id: GO:0070004
@@ -373250,24 +371151,6 @@ def: "Catalysis of the hydrolysis of a peptide bond not more than three residues
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0070008 ! serine-type exopeptidase activity
-[Term]
-id: GO:0070010
-name: peptidase activity, acting on D-amino acid peptides
-namespace: molecular_function
-def: "Catalysis of the hydrolysis of peptide bonds formed between D-amino acids." [GOC:mah]
-is_a: GO:0008233 ! peptidase activity
-
-[Term]
-id: GO:0070011
-name: peptidase activity, acting on L-amino acid peptides
-namespace: molecular_function
-def: "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids." [GOC:mah]
-xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA"
-xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs"
-xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB"
-xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)"
-is_a: GO:0008233 ! peptidase activity
-
[Term]
id: GO:0070012
name: oligopeptidase activity
@@ -373407,8 +371290,6 @@ name: carbon monoxide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with carbon monoxide (CO)." [GOC:ecd]
synonym: "CO binding" EXACT []
-is_a: GO:0008144 ! drug binding
-is_a: GO:0042165 ! neurotransmitter binding
is_a: GO:0043169 ! cation binding
[Term]
@@ -374493,7 +372374,7 @@ name: SUMO-specific endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah]
xref: Reactome:R-HSA-2990840 "SENP1,2,5 proteolytically process SUMO1"
-xref: Reactome:R-HSA-2990842 "SEN1,2,5 proteolytically process SUMO2"
+xref: Reactome:R-HSA-2990842 "SENP1,2,5 proteolytically process SUMO2"
xref: Reactome:R-HSA-2993763 "SENP1,2,5 proteolytically process SUMO3"
is_a: GO:0016929 ! SUMO-specific protease activity
is_a: GO:0070137 ! ubiquitin-like protein-specific endopeptidase activity
@@ -374906,7 +372787,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid." [CHEBI:16523, GOC:jsg, GOC:mah]
synonym: "D-serine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process
[Term]
@@ -375377,6 +373257,7 @@ synonym: "sulfide-quinone reductase activity" EXACT [MetaCyc:MONOMER-12314]
synonym: "sulphide:quinone oxidoreductase activity" EXACT [GOC:mah]
xref: MetaCyc:R17-RXN
xref: Reactome:R-HSA-1614665 "SQR oxidizes sulfide to bound persulfide"
+xref: RHEA:30239
is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor
[Term]
@@ -375388,6 +373269,7 @@ synonym: "flavocytochrome c sulfide dehydrogenase activity" EXACT [MetaCyc:RXN-8
synonym: "sulphide dehydrogenase activity" EXACT [GOC:mah]
xref: EC:1.8.2
xref: MetaCyc:RXN-8156
+xref: RHEA:30223
is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor
[Term]
@@ -375796,6 +373678,7 @@ def: "Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pr
synonym: "pristanate:CoA ligase (AMP-forming)" EXACT [GOC:mah]
synonym: "pristanoyl-CoA ligase activity" EXACT [GOC:mah]
xref: Reactome:R-HSA-389632 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate"
+xref: RHEA:47264
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity
@@ -376031,7 +373914,7 @@ is_a: GO:0019329 ! ammonia oxidation
id: GO:0070276
name: halogen metabolic process
namespace: biological_process
-def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [CHEBI:22473, GOC:mah]
+def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [GOC:mah]
synonym: "halogen metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
@@ -376058,7 +373941,6 @@ id: GO:0070279
name: vitamin B6 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah]
-is_a: GO:0008144 ! drug binding
is_a: GO:0019842 ! vitamin binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
@@ -376069,7 +373951,6 @@ name: pyridoxal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah]
is_a: GO:0043169 ! cation binding
-is_a: GO:0048037 ! cofactor binding
is_a: GO:0070279 ! vitamin B6 binding
[Term]
@@ -376085,7 +373966,6 @@ id: GO:0070282
name: pyridoxine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16709, GOC:mah]
-is_a: GO:0048037 ! cofactor binding
is_a: GO:0070279 ! vitamin B6 binding
[Term]
@@ -376272,10 +374152,7 @@ name: cellular response to hydrogen peroxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [CHEBI:16240, GOC:mah]
is_a: GO:0034614 ! cellular response to reactive oxygen species
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0042542 ! response to hydrogen peroxide
-is_a: GO:0071236 ! cellular response to antibiotic
-is_a: GO:0097237 ! cellular response to toxic substance
[Term]
id: GO:0070302
@@ -376589,6 +374466,7 @@ def: "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
synonym: "estrogen synthetase activity" NARROW []
xref: EC:1.14.14.1
xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
+xref: RHEA:17149
xref: UM-BBD_enzymeID:e0551
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
@@ -377899,7 +375777,6 @@ synonym: "regulation of heme anabolism" EXACT [GOC:mah]
synonym: "regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "regulation of heme formation" EXACT [GOC:mah]
synonym: "regulation of heme synthesis" EXACT [GOC:mah]
-is_a: GO:0051193 ! regulation of cofactor metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0006783 ! heme biosynthetic process
@@ -377919,7 +375796,6 @@ synonym: "negative regulation of heme anabolism" EXACT [GOC:mah]
synonym: "negative regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of heme formation" EXACT [GOC:mah]
synonym: "negative regulation of heme synthesis" EXACT [GOC:mah]
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:0070453 ! regulation of heme biosynthetic process
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -377941,7 +375817,6 @@ synonym: "stimulation of heme biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of heme biosynthetic process" EXACT [GOC:mah]
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:0070453 ! regulation of heme biosynthetic process
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -378238,7 +376113,6 @@ name: dehydro-D-arabinono-1,4-lactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [GOC:cjk, GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone metabolism" EXACT [GOC:mah]
-is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:1901334 ! lactone metabolic process
[Term]
@@ -378250,7 +376124,6 @@ synonym: "dehydro-D-arabinono-1,4-lactone anabolism" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone biosynthesis" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone formation" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone synthesis" EXACT [GOC:mah]
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0070484 ! dehydro-D-arabinono-1,4-lactone metabolic process
is_a: GO:1901336 ! lactone biosynthetic process
@@ -378643,6 +376516,7 @@ synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146]
xref: EC:1.1.1.146
xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
+xref: RHEA:11388
is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
[Term]
@@ -378780,7 +376654,6 @@ id: GO:0070542
name: response to fatty acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:lp]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -379700,7 +377573,6 @@ is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0009229 ! thiamine diphosphate biosynthetic process
relationship: regulates GO:0009229 ! thiamine diphosphate biosynthetic process
@@ -379726,7 +377598,6 @@ is_a: GO:0045936 ! negative regulation of phosphate metabolic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0070616 ! regulation of thiamine diphosphate biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0009229 ! thiamine diphosphate biosynthetic process
@@ -379850,6 +377721,7 @@ synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah]
xref: EC:4.3.2.2
xref: KEGG_REACTION:R04559
xref: MetaCyc:AICARSYN-RXN
+xref: RHEA:23920
is_a: GO:0016842 ! amidine-lyase activity
created_by: mah
creation_date: 2009-05-01T04:13:49Z
@@ -379909,10 +377781,6 @@ namespace: biological_process
alt_id: GO:0071790
alt_id: GO:1990944
def: "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah]
-synonym: "establishment and maintenance of spindle pole body localization" EXACT [GOC:mah]
-synonym: "establishment of spindle pole body localisation in nuclear envelope" NARROW [GOC:mah]
-synonym: "establishment of spindle pole body localization in nuclear envelope" NARROW []
-synonym: "establishment of spindle pole body localization to nuclear envelope" NARROW []
synonym: "maintenance of spindle pole body localization" NARROW []
synonym: "spindle pole body localisation" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization
@@ -379999,7 +377867,6 @@ def: "The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9
synonym: "calciferol metabolic process" EXACT [CHEBI:28934]
synonym: "ergocalciferol metabolic process" EXACT [CHEBI:28934]
synonym: "vitamin D2 metabolism" EXACT [GOC:mah]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0042359 ! vitamin D metabolic process
created_by: mah
creation_date: 2009-05-08T02:11:35Z
@@ -380013,7 +377880,6 @@ synonym: "calciol metabolic process" EXACT [CHEBI:28940]
synonym: "cholecalciferol metabolic process" EXACT [CHEBI:28940]
synonym: "vitamin D3 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process
-is_a: GO:0042445 ! hormone metabolic process
is_a: GO:1902652 ! secondary alcohol metabolic process
created_by: mah
creation_date: 2009-05-08T02:24:24Z
@@ -380562,7 +378428,6 @@ synonym: "threonine catabolic process to propionate" BROAD [GOC:bf]
xref: MetaCyc:PWY-5437
is_a: GO:0006567 ! threonine catabolic process
is_a: GO:0019541 ! propionate metabolic process
-is_a: GO:0042737 ! drug catabolic process
created_by: mah
creation_date: 2009-06-03T01:36:54Z
@@ -380578,7 +378443,6 @@ synonym: "threonine catabolic process to acetyl-CoA" BROAD [GOC:bf]
xref: MetaCyc:PWY-5436
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0006567 ! threonine catabolic process
-is_a: GO:0042737 ! drug catabolic process
created_by: mah
creation_date: 2009-06-03T01:40:22Z
@@ -381211,138 +379075,64 @@ is_a: GO:0005126 ! cytokine receptor binding
created_by: mah
creation_date: 2009-06-23T01:21:54Z
-[Term]
-id: GO:0070749
-name: interleukin-35 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
-synonym: "IL-35 biosynthesis" EXACT [GOC:mah]
-synonym: "IL-35 biosynthetic process" EXACT [GOC:add]
-synonym: "interleukin-35 anabolism" EXACT [GOC:mah]
-synonym: "interleukin-35 biosynthesis" EXACT [GOC:mah]
-synonym: "interleukin-35 formation" EXACT [GOC:mah]
-synonym: "interleukin-35 synthesis" EXACT [GOC:mah]
-is_a: GO:0042089 ! cytokine biosynthetic process
-relationship: part_of GO:0070753 ! interleukin-35 production
-created_by: mah
-creation_date: 2009-06-23T01:25:11Z
-
-[Term]
-id: GO:0070750
-name: regulation of interleukin-35 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
-synonym: "regulation of IL-35 biosynthesis" EXACT [GOC:mah]
-synonym: "regulation of IL-35 biosynthetic process" EXACT [GOC:add]
-synonym: "regulation of interleukin-35 anabolism" EXACT [GOC:mah]
-synonym: "regulation of interleukin-35 biosynthesis" EXACT [GOC:mah]
-synonym: "regulation of interleukin-35 formation" EXACT [GOC:mah]
-synonym: "regulation of interleukin-35 synthesis" EXACT [GOC:mah]
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-is_a: GO:0070754 ! regulation of interleukin-35 production
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0070749 ! interleukin-35 biosynthetic process
-relationship: regulates GO:0070749 ! interleukin-35 biosynthetic process
-created_by: mah
-creation_date: 2009-06-23T01:29:17Z
-
-[Term]
-id: GO:0070751
-name: negative regulation of interleukin-35 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
-synonym: "down regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
-synonym: "down-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
-synonym: "downregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
-synonym: "inhibition of interleukin-35 biosynthetic process" NARROW [GOC:mah]
-synonym: "negative regulation of IL-35 biosynthesis" EXACT [GOC:mah]
-synonym: "negative regulation of IL-35 biosynthetic process" EXACT [GOC:add]
-synonym: "negative regulation of interleukin-35 anabolism" EXACT [GOC:mah]
-synonym: "negative regulation of interleukin-35 biosynthesis" EXACT [GOC:mah]
-synonym: "negative regulation of interleukin-35 formation" EXACT [GOC:mah]
-synonym: "negative regulation of interleukin-35 synthesis" EXACT [GOC:mah]
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process
-is_a: GO:0070755 ! negative regulation of interleukin-35 production
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process
-relationship: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process
-created_by: mah
-creation_date: 2009-06-23T01:34:54Z
-
-[Term]
-id: GO:0070752
-name: positive regulation of interleukin-35 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
-synonym: "activation of interleukin-35 biosynthetic process" NARROW [GOC:mah]
-synonym: "positive regulation of IL-35 biosynthesis" EXACT [GOC:mah]
-synonym: "positive regulation of IL-35 biosynthetic process" EXACT [GOC:add]
-synonym: "positive regulation of interleukin-35 anabolism" EXACT [GOC:mah]
-synonym: "positive regulation of interleukin-35 biosynthesis" EXACT [GOC:mah]
-synonym: "positive regulation of interleukin-35 formation" EXACT [GOC:mah]
-synonym: "positive regulation of interleukin-35 synthesis" EXACT [GOC:mah]
-synonym: "stimulation of interleukin-35 biosynthetic process" NARROW [GOC:mah]
-synonym: "up regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
-synonym: "up-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
-synonym: "upregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process
-is_a: GO:0070756 ! positive regulation of interleukin-35 production
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process
-relationship: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process
-created_by: mah
-creation_date: 2009-06-23T01:39:45Z
-
[Term]
id: GO:0070753
name: interleukin-35 production
namespace: biological_process
+alt_id: GO:0070749
+alt_id: GO:0072626
def: "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-35 production" EXACT [GOC:add]
+synonym: "interleukin-35 biosynthetic process" NARROW []
+synonym: "interleukin-35 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
created_by: mah
-creation_date: 2009-06-23T01:42:04Z
+creation_date: 2009-06-23T01:25:11Z
[Term]
id: GO:0070754
name: regulation of interleukin-35 production
namespace: biological_process
+alt_id: GO:0070750
def: "Any process that modulates the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "regulation of IL-35 production" EXACT [GOC:add]
+synonym: "regulation of interleukin-35 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0070753 ! interleukin-35 production
relationship: regulates GO:0070753 ! interleukin-35 production
created_by: mah
-creation_date: 2009-06-23T01:44:37Z
+creation_date: 2009-06-23T01:29:17Z
[Term]
id: GO:0070755
name: negative regulation of interleukin-35 production
namespace: biological_process
+alt_id: GO:0070751
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "down regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "down-regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "downregulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "inhibition of interleukin-35 production" NARROW [GOC:mah]
synonym: "negative regulation of IL-35 production" EXACT [GOC:add]
+synonym: "negative regulation of interleukin-35 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0070754 ! regulation of interleukin-35 production
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0070753 ! interleukin-35 production
relationship: negatively_regulates GO:0070753 ! interleukin-35 production
created_by: mah
-creation_date: 2009-06-23T01:48:25Z
+creation_date: 2009-06-23T01:34:54Z
[Term]
id: GO:0070756
name: positive regulation of interleukin-35 production
namespace: biological_process
+alt_id: GO:0070752
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "activation of interleukin-35 production" NARROW [GOC:mah]
synonym: "positive regulation of IL-35 production" EXACT [GOC:add]
+synonym: "positive regulation of interleukin-35 biosynthetic process" NARROW []
synonym: "stimulation of interleukin-35 production" NARROW [GOC:mah]
synonym: "up regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "up-regulation of interleukin-35 production" EXACT [GOC:mah]
@@ -381353,7 +379143,7 @@ intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0070753 ! interleukin-35 production
relationship: positively_regulates GO:0070753 ! interleukin-35 production
created_by: mah
-creation_date: 2009-06-23T01:52:31Z
+creation_date: 2009-06-23T01:39:45Z
[Term]
id: GO:0070757
@@ -381597,7 +379387,6 @@ namespace: biological_process
alt_id: GO:0089712
def: "The directed movement of L-aspartate across a membrane." [PMID:21307582]
synonym: "L-aspartate transport" BROAD []
-is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0015740 ! C4-dicarboxylate transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
created_by: mah
@@ -381626,6 +379415,7 @@ synonym: "dihydrosphingosine-1-phosphate phosphohydrolase activity" EXACT [GOC:m
synonym: "sphinganine-1-phosphate phosphatase activity" EXACT [GOC:mah]
xref: MetaCyc:RXN3DJ-25
xref: Reactome:R-HSA-428664 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate"
+xref: RHEA:27514
is_a: GO:0016791 ! phosphatase activity
created_by: mah
creation_date: 2009-07-02T02:13:49Z
@@ -381639,11 +379429,9 @@ synonym: "response to Bios IIB" EXACT [GOC:sl]
synonym: "response to coenzyme R" EXACT [GOC:sl]
synonym: "response to vitamin B7" EXACT [GOC:sl]
synonym: "response to vitamin H" EXACT [GOC:sl]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033273 ! response to vitamin
-is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2009-07-02T02:34:43Z
@@ -382098,8 +379886,6 @@ synonym: "hydrogen sulfide metabolism" EXACT [GOC:mah]
synonym: "hydrogen sulphide metabolic process" EXACT [GOC:mah]
synonym: "hydrogen sulphide metabolism" EXACT [GOC:mah]
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0009404 ! toxin metabolic process
-is_a: GO:0017144 ! drug metabolic process
created_by: mah
creation_date: 2009-07-09T10:37:32Z
@@ -382114,7 +379900,6 @@ synonym: "hydrogen sulfide formation" EXACT [GOC:mah]
synonym: "hydrogen sulfide synthesis" EXACT [GOC:mah]
synonym: "hydrogen sulphide biosynthesis" EXACT [GOC:mah]
synonym: "hydrogen sulphide biosynthetic process" EXACT [GOC:mah]
-is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0070813 ! hydrogen sulfide metabolic process
created_by: mah
@@ -383007,6 +380792,7 @@ name: sodium-dependent L-ascorbate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)." [GOC:mah, GOC:yaf, PMID:18094143]
is_a: GO:0008520 ! L-ascorbate:sodium symporter activity
+is_a: GO:0015229 ! L-ascorbic acid transmembrane transporter activity
created_by: mah
creation_date: 2009-09-01T02:25:22Z
@@ -383198,8 +380984,6 @@ synonym: "transepithelial L-ascorbate transport" EXACT [GOC:mah]
synonym: "transepithelial vitamin C transport" EXACT [GOC:mah]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0046942 ! carboxylic acid transport
-is_a: GO:0051180 ! vitamin transport
-is_a: GO:0051182 ! coenzyme transport
is_a: GO:0070633 ! transepithelial transport
created_by: mah
creation_date: 2009-09-03T02:21:25Z
@@ -383237,7 +381021,6 @@ namespace: molecular_function
def: "Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)." [GOC:dh]
synonym: "histidine-histamine antiporter activity" EXACT [GOC:mah]
synonym: "histidine/histamine antiporter activity" EXACT [GOC:mah]
-is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015491 ! cation:cation antiporter activity
is_a: GO:1901474 ! azole transmembrane transporter activity
@@ -383251,8 +381034,8 @@ namespace: molecular_function
def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh]
synonym: "tyrosine-tyramine antiporter activity" EXACT [GOC:mah]
synonym: "tyrosine/tyramine antiporter activity" EXACT [GOC:mah]
-is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0008504 ! monoamine transmembrane transporter activity
+is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015491 ! cation:cation antiporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
@@ -383459,7 +381242,6 @@ def: "Any process that modulates the activity of an ATP:ADP antiporter." [GOC:BH
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:1903959 ! regulation of anion transmembrane transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0005471 ! ATP:ADP antiporter activity
relationship: regulates GO:0005471 ! ATP:ADP antiporter activity
@@ -383479,7 +381261,6 @@ is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transpo
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:0070926 ! regulation of ATP:ADP antiporter activity
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0005471 ! ATP:ADP antiporter activity
relationship: negatively_regulates GO:0005471 ! ATP:ADP antiporter activity
@@ -383727,7 +381508,7 @@ def: "Any process that modulates the rate, frequency or extent of neutrophil med
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
is_a: GO:0051709 ! regulation of killing of cells of other organism
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
intersection_of: GO:0008150 ! biological_process
@@ -384030,7 +381811,6 @@ name: coenzyme F420 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:dh]
is_a: GO:0031406 ! carboxylic acid binding
-is_a: GO:0050662 ! coenzyme binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:0097367 ! carbohydrate derivative binding
is_a: GO:1901363 ! heterocyclic compound binding
@@ -384043,7 +381823,6 @@ name: pyrroloquinoline quinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases." [GOC:dh]
synonym: "PQQ binding" EXACT [GOC:dh]
-is_a: GO:0019842 ! vitamin binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0048038 ! quinone binding
is_a: GO:0097159 ! organic cyclic compound binding
@@ -384051,17 +381830,6 @@ is_a: GO:1901363 ! heterocyclic compound binding
created_by: mah
creation_date: 2009-10-02T11:39:13Z
-[Term]
-id: GO:0070970
-name: interleukin-2 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-2 from a cell." [GOC:mah, PMID:16930574]
-synonym: "IL-2 secretion" EXACT [GOC:mah]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032623 ! interleukin-2 production
-created_by: mah
-creation_date: 2009-10-02T12:03:07Z
-
[Term]
id: GO:0070971
name: endoplasmic reticulum exit site
@@ -384164,7 +381932,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of biphenyl
synonym: "biphenyl breakdown" EXACT [GOC:mah]
synonym: "biphenyl catabolism" EXACT [GOC:mah]
synonym: "biphenyl degradation" EXACT [GOC:mah]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0018879 ! biphenyl metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
@@ -384193,7 +381960,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [GOC:mah]
synonym: "L-asparagine metabolism" EXACT [GOC:mah]
is_a: GO:0006528 ! asparagine metabolic process
-is_a: GO:0017144 ! drug metabolic process
created_by: mah
creation_date: 2009-10-27T01:03:46Z
@@ -386202,6 +383968,7 @@ name: cyanophycin synthetase activity (L-aspartate-adding)
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp." [EC:6.3.2.29]
xref: EC:6.3.2.29
+xref: RHEA:13277
is_a: GO:0043860 ! cyanophycin synthetase activity
created_by: mah
creation_date: 2009-11-17T05:18:17Z
@@ -386212,6 +383979,7 @@ name: cyanophycin synthetase activity (L-arginine-adding)
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1." [EC:6.3.2.30]
xref: EC:6.3.2.30
+xref: RHEA:23888
is_a: GO:0043860 ! cyanophycin synthetase activity
created_by: mah
creation_date: 2009-11-17T05:19:54Z
@@ -386802,7 +384570,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:mah]
is_a: GO:0009737 ! response to abscisic acid
is_a: GO:0032870 ! cellular response to hormone stimulus
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0097306 ! cellular response to alcohol
created_by: mah
@@ -386919,7 +384686,6 @@ name: cellular response to muramyl dipeptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:mah]
is_a: GO:0032495 ! response to muramyl dipeptide
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:1901653 ! cellular response to peptide
created_by: mah
creation_date: 2009-12-03T01:41:23Z
@@ -386993,9 +384759,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:mah]
synonym: "response to folate" EXACT [GOC:mah]
synonym: "response to vitamin B9" EXACT [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0051593 ! response to folic acid
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
@@ -387084,10 +384848,8 @@ id: GO:0071239
name: cellular response to streptomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0046679 ! response to streptomycin
is_a: GO:0071236 ! cellular response to antibiotic
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
creation_date: 2009-12-03T02:25:59Z
@@ -387116,7 +384878,9 @@ creation_date: 2009-12-03T02:35:49Z
id: GO:0071242
name: cellular response to ammonium ion
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:mah]
+alt_id: GO:1903718
+def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267]
+synonym: "cellular response to ammonia" EXACT []
is_a: GO:0060359 ! response to ammonium ion
is_a: GO:1901699 ! cellular response to nitrogen compound
created_by: mah
@@ -387139,7 +384903,6 @@ name: cellular response to carbon dioxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah]
is_a: GO:0010037 ! response to carbon dioxide
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -387151,9 +384914,7 @@ name: cellular response to carbon monoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:mah]
is_a: GO:0034465 ! response to carbon monoxide
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071241 ! cellular response to inorganic substance
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
creation_date: 2009-12-03T02:44:43Z
@@ -387164,7 +384925,6 @@ name: cellular response to chlorate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:mah]
is_a: GO:0010157 ! response to chlorate
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -387199,7 +384959,6 @@ name: cellular response to nitrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah]
is_a: GO:0010167 ! response to nitrate
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1902170 ! cellular response to reactive nitrogen species
@@ -387211,7 +384970,6 @@ id: GO:0071250
name: cellular response to nitrite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:mah]
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0080033 ! response to nitrite
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -387400,7 +385158,6 @@ synonym: "L-methionine biosynthesis" EXACT [GOC:mah]
synonym: "L-methionine formation" EXACT [GOC:mah]
synonym: "L-methionine synthesis" EXACT [GOC:mah]
is_a: GO:0009086 ! methionine biosynthetic process
-is_a: GO:0017144 ! drug metabolic process
created_by: mah
creation_date: 2009-12-09T04:28:15Z
@@ -387491,8 +385248,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [GOC:mah]
synonym: "morphine metabolism" EXACT [GOC:mah]
xref: Wikipedia:Morphine
-is_a: GO:0006805 ! xenobiotic metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: mah
@@ -387507,8 +385262,6 @@ synonym: "morphine breakdown" EXACT [GOC:mah]
synonym: "morphine catabolism" EXACT [GOC:mah]
synonym: "morphine degradation" EXACT [GOC:mah]
xref: UniPathway:Q02198
-is_a: GO:0042178 ! xenobiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0071272 ! morphine metabolic process
is_a: GO:0071274 ! isoquinoline alkaloid catabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
@@ -387767,9 +385520,7 @@ synonym: "cellular response to Bios IIB" EXACT [GOC:sl]
synonym: "cellular response to coenzyme R" EXACT [GOC:sl]
synonym: "cellular response to vitamin B7" EXACT [GOC:sl]
synonym: "cellular response to vitamin H" EXACT [GOC:sl]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0070781 ! response to biotin
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
@@ -387784,7 +385535,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:mah]
synonym: "cellular response to vitamin B12" EXACT [GOC:mah]
is_a: GO:0033590 ! response to cobalamin
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
@@ -387800,7 +385550,6 @@ synonym: "cellular response to ascorbic acid" BROAD [GOC:mah]
synonym: "cellular response to L-ascorbate" EXACT [GOC:mah]
synonym: "cellular response to vitamin C" EXACT [GOC:mah]
is_a: GO:0033591 ! response to L-ascorbic acid
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071326 ! cellular response to monosaccharide stimulus
created_by: mah
@@ -387825,7 +385574,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:mah]
synonym: "cellular response to vitamin A acid" EXACT [GOC:mah]
is_a: GO:0032526 ! response to retinoic acid
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -387839,7 +385587,6 @@ def: "Any process that results in a change in state or activity of a cell (in te
synonym: "cellular response to thiamin" EXACT [GOC:mah]
synonym: "cellular response to thiamine" EXACT [GOC:mah]
is_a: GO:0010266 ! response to vitamin B1
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
@@ -387853,7 +385600,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:mah]
synonym: "cellular response to riboflavin" EXACT [GOC:mah]
is_a: GO:0033274 ! response to vitamin B2
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
@@ -387878,7 +385624,6 @@ name: cellular response to vitamin B6
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah]
is_a: GO:0034516 ! response to vitamin B6
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
@@ -387946,7 +385691,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:mah]
synonym: "cellular response to vitamin K1" EXACT [GOC:mah]
is_a: GO:0032573 ! response to phylloquinone
-is_a: GO:0071295 ! cellular response to vitamin
is_a: GO:1901655 ! cellular response to ketone
created_by: mah
creation_date: 2009-12-10T04:37:18Z
@@ -387967,8 +385711,6 @@ name: cellular response to acetate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:mah]
is_a: GO:0010034 ! response to acetate
-is_a: GO:0071229 ! cellular response to acid chemical
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -387990,10 +385732,8 @@ name: cellular response to caffeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:mah]
is_a: GO:0031000 ! response to caffeine
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071415 ! cellular response to purine-containing compound
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
created_by: mah
creation_date: 2009-12-10T04:52:51Z
@@ -388002,11 +385742,9 @@ id: GO:0071314
name: cellular response to cocaine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0042220 ! response to cocaine
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
creation_date: 2009-12-10T04:53:20Z
@@ -388016,10 +385754,8 @@ id: GO:0071315
name: cellular response to morphine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0043278 ! response to morphine
is_a: GO:0071317 ! cellular response to isoquinoline alkaloid
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
created_by: mah
creation_date: 2009-12-10T04:53:46Z
@@ -388029,8 +385765,7 @@ name: cellular response to nicotine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:mah]
is_a: GO:0035094 ! response to nicotine
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0097237 ! cellular response to toxic substance
+is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: mah
creation_date: 2009-12-10T05:05:05Z
@@ -388052,9 +385787,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:mah]
synonym: "cellular response to adenosine 5'-triphosphate" EXACT [GOC:mah]
synonym: "cellular response to adenosine triphosphate" EXACT [GOC:mah]
-is_a: GO:0031670 ! cellular response to nutrient
is_a: GO:0033198 ! response to ATP
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -388066,9 +385799,6 @@ id: GO:0071319
name: cellular response to benzoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071229 ! cellular response to acid chemical
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0080021 ! response to benzoic acid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -388124,7 +385854,6 @@ name: cellular response to chitin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:mah]
is_a: GO:0010200 ! response to chitin
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -388388,7 +386117,7 @@ creation_date: 2009-12-11T02:41:12Z
id: GO:0071346
name: cellular response to interferon-gamma
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far." [GOC:mah, PR:000000017]
+def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far." [GOC:mah]
synonym: "cellular response to gamma-interferon" RELATED [GOC:mah]
synonym: "cellular response to immune interferon" EXACT [GOC:mah]
synonym: "cellular response to type II IFN" BROAD [GOC:mah]
@@ -388512,7 +386241,7 @@ creation_date: 2009-12-11T02:51:37Z
id: GO:0071357
name: cellular response to type I interferon
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah, PR:000025848]
+def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah]
synonym: "cellular response to type I IFN" EXACT [GOC:mah]
is_a: GO:0034340 ! response to type I interferon
is_a: GO:0071345 ! cellular response to cytokine stimulus
@@ -388560,10 +386289,7 @@ id: GO:0071361
name: cellular response to ethanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0045471 ! response to ethanol
-is_a: GO:0071236 ! cellular response to antibiotic
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:0097306 ! cellular response to alcohol
created_by: mah
creation_date: 2009-12-11T03:02:59Z
@@ -388617,7 +386343,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [GOC:mah]
synonym: "cellular response to IBA stimulus" EXACT [GOC:mah]
synonym: "cellular response to indole-3-butyric acid stimulus" NARROW [GOC:mah]
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071365 ! cellular response to auxin stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
@@ -388668,7 +386393,6 @@ def: "Any process that results in a change in state or activity of a cell (in te
synonym: "cellular response to gibberellic acid stimulus" NARROW [GOC:mah]
is_a: GO:0009739 ! response to gibberellin
is_a: GO:0032870 ! cellular response to hormone stimulus
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -388859,7 +386583,6 @@ name: cellular response to cortisol stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [GOC:mah]
synonym: "cellular response to hydrocortisone stimulus" EXACT [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0051414 ! response to cortisol
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0097306 ! cellular response to alcohol
@@ -388894,7 +386617,6 @@ id: GO:0071390
name: cellular response to ecdysone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah]
-is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0035075 ! response to ecdysone
is_a: GO:0036315 ! cellular response to sterol
is_a: GO:0097306 ! cellular response to alcohol
@@ -388908,8 +386630,8 @@ name: cellular response to estrogen stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:mah]
synonym: "cellular response to oestrogen stimulus" EXACT [GOC:mah]
+is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0043627 ! response to estrogen
-is_a: GO:0070887 ! cellular response to chemical stimulus
created_by: mah
creation_date: 2009-12-11T04:09:56Z
@@ -388920,7 +386642,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah]
synonym: "cellular response to E2 stimulus" EXACT [GOC:mah]
is_a: GO:0032355 ! response to estradiol
-is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -388933,7 +386654,6 @@ name: cellular response to progesterone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:mah]
is_a: GO:0032570 ! response to progesterone
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071383 ! cellular response to steroid hormone stimulus
is_a: GO:1901655 ! cellular response to ketone
created_by: mah
@@ -388944,7 +386664,6 @@ id: GO:0071394
name: cellular response to testosterone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:mah]
-is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0033574 ! response to testosterone
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
@@ -388959,7 +386678,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:mah]
is_a: GO:0009753 ! response to jasmonic acid
is_a: GO:0032870 ! cellular response to hormone stimulus
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
creation_date: 2009-12-11T04:13:34Z
@@ -388991,7 +386709,6 @@ name: cellular response to fatty acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:mah]
is_a: GO:0070542 ! response to fatty acid
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -389074,7 +386791,6 @@ name: cellular response to methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:mah]
is_a: GO:0033986 ! response to methanol
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0097306 ! cellular response to alcohol
created_by: mah
creation_date: 2009-12-14T02:54:44Z
@@ -389118,12 +386834,9 @@ name: cellular response to cycloheximide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:mah]
synonym: "cellular response to actidione" EXACT [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0046898 ! response to cycloheximide
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
created_by: mah
@@ -389148,7 +386861,6 @@ comment: Note that this term is in the subset of terms that should not be used f
subset: gocheck_do_not_manually_annotate
is_a: GO:0014076 ! response to fluoxetine
is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
created_by: mah
creation_date: 2009-12-14T03:09:58Z
@@ -389157,9 +386869,7 @@ id: GO:0071412
name: cellular response to genistein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah]
-is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0033595 ! response to genistein
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071413 ! cellular response to hydroxyisoflavone
created_by: mah
creation_date: 2009-12-14T03:10:04Z
@@ -389181,8 +386891,6 @@ name: cellular response to methotrexate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:mah]
is_a: GO:0031427 ! response to methotrexate
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -389241,10 +386949,7 @@ name: cellular response to amphetamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:mah]
is_a: GO:0001975 ! response to amphetamine
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071418 ! cellular response to amine stimulus
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
-is_a: GO:0097237 ! cellular response to toxic substance
created_by: mah
creation_date: 2009-12-14T04:09:02Z
@@ -389281,7 +386986,6 @@ def: "The process in which succinate is transported across a membrane." [GOC:mah
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "succinate membrane transport" EXACT []
synonym: "transmembrane succinate transport" EXACT [GOC:mah]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015744 ! succinate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: mah
@@ -389566,10 +387270,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:mah]
synonym: "cellular response to salicylate stimulus" EXACT [GOC:dph]
is_a: GO:0009751 ! response to salicylic acid
-is_a: GO:0032870 ! cellular response to hormone stimulus
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071229 ! cellular response to acid chemical
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -389633,9 +387333,7 @@ name: cellular response to singlet oxygen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:mah]
is_a: GO:0000304 ! response to singlet oxygen
-is_a: GO:0031670 ! cellular response to nutrient
is_a: GO:0034614 ! cellular response to reactive oxygen species
-is_a: GO:0035690 ! cellular response to drug
created_by: mah
creation_date: 2009-12-16T04:39:46Z
@@ -389698,9 +387396,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:mah]
is_a: GO:0010193 ! response to ozone
is_a: GO:0034614 ! cellular response to reactive oxygen species
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071229 ! cellular response to acid chemical
-is_a: GO:0071236 ! cellular response to antibiotic
created_by: mah
creation_date: 2009-12-16T04:45:59Z
@@ -390225,7 +387920,6 @@ name: response to heparin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0010243 ! response to organonitrogen compound
-is_a: GO:0061476 ! response to anticoagulant
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2009-12-18T03:33:49Z
@@ -390235,7 +387929,6 @@ id: GO:0071504
name: cellular response to heparin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0071503 ! response to heparin
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -390248,12 +387941,7 @@ name: response to mycophenolic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [GOC:mah, GOC:yaf]
synonym: "response to mycophenolate" EXACT [GOC:mah]
-is_a: GO:0001101 ! response to acid chemical
-is_a: GO:0009410 ! response to xenobiotic stimulus
-is_a: GO:0010046 ! response to mycotoxin
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2009-12-18T03:46:00Z
@@ -390264,12 +387952,7 @@ name: cellular response to mycophenolic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [GOC:mah, GOC:yaf]
synonym: "cellular response to mycophenolate" EXACT [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0036146 ! cellular response to mycotoxin
-is_a: GO:0071229 ! cellular response to acid chemical
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
is_a: GO:0071505 ! response to mycophenolic acid
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -390431,8 +388114,9 @@ id: GO:0071518
name: autoinducer-2 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP." [GOC:imk, PMID:17274596, PMID:20025244]
-synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [CHEBI:425228, GOC:mah]
+synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [CHEBI:29484, GOC:mah]
xref: MetaCyc:RXN0-5461
+xref: RHEA:15377
is_a: GO:0016301 ! kinase activity
created_by: mah
creation_date: 2010-01-06T05:08:17Z
@@ -390483,6 +388167,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3." [MetaCyc:URUR-RXN, PMID:19935661, PMID:20038185]
xref: EC:3.5.3.26
xref: MetaCyc:URUR-RXN
+xref: RHEA:25241
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
created_by: mah
creation_date: 2010-01-07T01:43:58Z
@@ -390775,9 +388460,7 @@ name: response to dexamethasone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf]
synonym: "response to dexamethasone stimulus" EXACT [GOC:dos]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0051384 ! response to glucocorticoid
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901654 ! response to ketone
created_by: mah
creation_date: 2010-01-13T01:24:40Z
@@ -390787,9 +388470,7 @@ id: GO:0071549
name: cellular response to dexamethasone stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
is_a: GO:0071548 ! response to dexamethasone
is_a: GO:1901655 ! cellular response to ketone
created_by: mah
@@ -390919,7 +388600,7 @@ name: histone demethylase activity (H3-K27 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein." [GOC:sp, PMID:20622853]
xref: EC:1.14.11.68
-xref: Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16-INK4A promoter"
+xref: Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter"
xref: Reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin"
xref: Reactome:R-HSA-5617887 "HOXC4 chromatin is activated"
is_a: GO:0032452 ! histone demethylase activity
@@ -391614,7 +389295,6 @@ synonym: "acyl-CoA biosynthesis" EXACT [GOC:mah]
synonym: "acyl-CoA formation" EXACT [GOC:mah]
synonym: "acyl-CoA synthesis" EXACT [GOC:mah]
is_a: GO:0006637 ! acyl-CoA metabolic process
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process
is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process
@@ -392501,7 +390181,6 @@ synonym: "response to indole-3-carbinol" EXACT [CHEBI:24814]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
-is_a: GO:0097327 ! response to antineoplastic agent
created_by: mah
creation_date: 2010-02-18T04:05:09Z
@@ -392511,7 +390190,6 @@ name: cellular response to indole-3-methanol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf]
synonym: "cellular response to indole-3-carbinol" EXACT [CHEBI:24814]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0071680 ! response to indole-3-methanol
@@ -393055,7 +390733,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0010035 ! response to inorganic substance
-is_a: GO:0097366 ! response to bronchodilator
is_a: GO:1901698 ! response to nitrogen compound
created_by: mah
creation_date: 2010-03-17T04:03:38Z
@@ -393066,7 +390743,6 @@ name: cellular response to nitric oxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0034614 ! cellular response to reactive oxygen species
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0071731 ! response to nitric oxide
is_a: GO:1902170 ! cellular response to reactive nitrogen species
@@ -393732,7 +391408,6 @@ synonym: "bacillithiol metabolism" EXACT [GOC:mah]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
created_by: mah
creation_date: 2010-09-02T11:13:47Z
@@ -393748,7 +391423,6 @@ synonym: "bacillithiol synthesis" EXACT [GOC:mah]
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0071792 ! bacillithiol metabolic process
created_by: mah
creation_date: 2010-09-02T11:16:04Z
@@ -394294,7 +391968,7 @@ creation_date: 2010-09-10T02:15:42Z
id: GO:0071847
name: TNFSF11-mediated signaling pathway
namespace: biological_process
-def: "A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:18606301, PR:000002107]
+def: "A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:18606301]
synonym: "RANKL-mediated signaling pathway" EXACT [GOC:BHF]
synonym: "receptor activator of nuclear factor kappa-B ligand signaling pathway" EXACT [Wikipedia:RANKL]
synonym: "TNF-related activation-induced cytokine-mediated signaling pathway" EXACT [Wikipedia:RANKL]
@@ -394739,7 +392413,6 @@ def: "Interacting selectively and non-covalently with the amine 1-(4-iodo-2,5-di
synonym: "(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding" EXACT [CHEBI:100436]
synonym: "1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding" EXACT [PMID:19057895]
synonym: "4-iodo-2,5-dimethoxyphenylisopropylamine binding" EXACT [PubChem_Compound:1229]
-is_a: GO:0008144 ! drug binding
is_a: GO:0043176 ! amine binding
is_a: GO:0097159 ! organic cyclic compound binding
created_by: mah
@@ -394775,7 +392448,7 @@ creation_date: 2010-09-14T12:50:40Z
id: GO:0071889
name: 14-3-3 protein binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, InterPro:IPR000308, PMID:15167810, PMID:19575580, PR:000003237]
+def: "Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580]
is_a: GO:0005515 ! protein binding
created_by: mah
creation_date: 2010-09-14T01:21:50Z
@@ -395300,7 +392973,6 @@ comment: Note that this term is not intended for use in annotating lateral movem
synonym: "thiamin transmembrane transport" EXACT [GOC:mah]
synonym: "thiamine membrane transport" EXACT []
synonym: "vitamin B1 transmembrane transport" EXACT [GOC:mah]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015888 ! thiamine transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0045117 ! azole transmembrane transport
@@ -395344,7 +393016,6 @@ namespace: biological_process
def: "The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]
synonym: "vitamin A uptake and transport" RELATED [GOC:rs]
is_a: GO:0015718 ! monocarboxylic acid transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0034633 ! retinol transport
is_a: GO:0051180 ! vitamin transport
created_by: mah
@@ -395356,7 +393027,6 @@ name: vitamin A import
namespace: biological_process
def: "The directed movement of vitamin A into a cell or organelle. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]
synonym: "vitamin A uptake" EXACT [GOC:mah, GOC:rs]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0071938 ! vitamin A transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
@@ -395662,6 +393332,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+." [MetaCyc:RXN0-5122]
synonym: "LPS core heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY]
xref: MetaCyc:RXN0-5122
+xref: RHEA:29923
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity
created_by: mah
creation_date: 2010-10-14T05:13:31Z
@@ -395672,6 +393343,7 @@ name: lipid A-core heptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+." [MetaCyc:RXN0-5127]
xref: MetaCyc:RXN0-5127
+xref: RHEA:30019
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity
created_by: mah
creation_date: 2010-10-14T05:15:22Z
@@ -399997,21 +397669,13 @@ is_a: GO:0008287 ! protein serine/threonine phosphatase complex
created_by: mah
creation_date: 2010-11-15T03:32:27Z
-[Term]
-id: GO:0072358
-name: cardiovascular system development
-namespace: biological_process
-def: "The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels." [GOC:mah, UBERON:0004535]
-is_a: GO:0048731 ! system development
-relationship: part_of GO:0072359 ! circulatory system development
-created_by: mah
-creation_date: 2010-11-16T11:25:49Z
-
[Term]
id: GO:0072359
name: circulatory system development
namespace: biological_process
+alt_id: GO:0072358
def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]
+synonym: "cardiovascular system development" NARROW []
is_a: GO:0048731 ! system development
created_by: mah
creation_date: 2010-11-16T11:27:39Z
@@ -400022,7 +397686,7 @@ name: vascular cord development
namespace: biological_process
def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077]
is_a: GO:0048856 ! anatomical structure development
-relationship: part_of GO:0072358 ! cardiovascular system development
+relationship: part_of GO:0072359 ! circulatory system development
created_by: mah
creation_date: 2010-11-16T11:46:55Z
@@ -400321,7 +397985,6 @@ def: "The chemical reactions and pathways involving flavin adenine dinucleotide,
synonym: "FAD or FADH2 metabolic process" EXACT []
synonym: "flavin adenine dinucleotide metabolism" EXACT []
synonym: "flavin-adenine dinucleotide metabolic process" EXACT []
-is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0042726 ! flavin-containing compound metabolic process
created_by: mah
@@ -400337,7 +398000,6 @@ synonym: "flavin adenine dinucleotide anabolism" EXACT []
synonym: "flavin adenine dinucleotide biosynthesis" EXACT []
synonym: "flavin adenine dinucleotide formation" EXACT []
synonym: "flavin adenine dinucleotide synthesis" EXACT []
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0042727 ! flavin-containing compound biosynthetic process
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process
@@ -400353,7 +398015,6 @@ synonym: "FAD or FADH2 catabolic process" EXACT []
synonym: "flavin adenine dinucleotide breakdown" EXACT []
synonym: "flavin adenine dinucleotide catabolism" EXACT []
synonym: "flavin adenine dinucleotide degradation" EXACT []
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0042728 ! flavin-containing compound catabolic process
is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process
@@ -400365,7 +398026,6 @@ id: GO:0072390
name: phenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah]
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
created_by: mah
creation_date: 2010-12-06T04:05:51Z
@@ -400375,7 +398035,6 @@ id: GO:0072391
name: phenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:0072390 ! phenol metabolic process
created_by: mah
@@ -400386,9 +398045,7 @@ id: GO:0072392
name: phenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072390 ! phenol metabolic process
created_by: mah
creation_date: 2010-12-06T04:08:44Z
@@ -401773,29 +399430,21 @@ relationship: part_of GO:0071465 ! cellular response to desiccation
created_by: mah
creation_date: 2010-12-21T11:30:31Z
-[Term]
-id: GO:0072516
-name: viral assembly compartment
-namespace: cellular_component
-def: "A membrane-bounded compartment that forms in the cytoplasm of virus-infected cells, in which virus assembly takes place." [GOC:BHF, PMID:20374631]
-synonym: "viral assembly site" RELATED [GOC:BHF]
-synonym: "virion assembly compartment" EXACT [GOC:mah]
-is_a: GO:0043231 ! intracellular membrane-bounded organelle
-relationship: part_of GO:0005737 ! cytoplasm
-created_by: mah
-creation_date: 2010-12-21T03:08:42Z
-
[Term]
id: GO:0072517
name: host cell viral assembly compartment
namespace: cellular_component
+alt_id: GO:0072516
def: "A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place." [GOC:BHF, PMID:20374631]
synonym: "host cell viral assembly site" RELATED [GOC:BHF]
synonym: "host cell virion assembly compartment" EXACT [GOC:mah]
+synonym: "viral assembly compartment" EXACT []
+synonym: "viral assembly site" RELATED []
+synonym: "virion assembly compartment" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0039714 ! cytoplasmic viral factory
created_by: mah
-creation_date: 2010-12-21T03:14:06Z
+creation_date: 2010-12-21T03:08:42Z
[Term]
id: GO:0072518
@@ -402124,7 +399773,6 @@ name: L-DOPA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid." [GOC:mah, GOC:vw]
synonym: "L-dopa binding" EXACT [CHEBI:15765]
-is_a: GO:0008144 ! drug binding
is_a: GO:0016597 ! amino acid binding
is_a: GO:0072341 ! modified amino acid binding
is_a: GO:0097159 ! organic cyclic compound binding
@@ -402536,6 +400184,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine." [GOC:kad, MetaCyc:RXN0-363, PMID:21235647]
synonym: "xanthosine ribohydrolase activity" EXACT [GOC:kad]
xref: MetaCyc:RXN0-363
+xref: RHEA:27994
is_a: GO:0008477 ! purine nucleosidase activity
created_by: mah
creation_date: 2011-02-08T04:38:31Z
@@ -402612,7 +400261,7 @@ namespace: biological_process
def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [GOC:mah]
synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263]
synonym: "oxygen metabolism" EXACT [GOC:mah]
-is_a: GO:0017144 ! drug metabolic process
+is_a: GO:0044237 ! cellular metabolic process
created_by: mah
creation_date: 2011-02-11T10:46:51Z
@@ -402705,419 +400354,96 @@ is_a: GO:0072594 ! establishment of protein localization to organelle
created_by: mah
creation_date: 2011-02-14T02:23:41Z
-[Term]
-id: GO:0072601
-name: interleukin-3 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-3 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-3 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032632 ! interleukin-3 production
-
-[Term]
-id: GO:0072602
-name: interleukin-4 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-4 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-4 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032633 ! interleukin-4 production
-
-[Term]
-id: GO:0072603
-name: interleukin-5 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-5 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-5 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032634 ! interleukin-5 production
-
-[Term]
-id: GO:0072604
-name: interleukin-6 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-6 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-6 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032635 ! interleukin-6 production
-
-[Term]
-id: GO:0072605
-name: interleukin-7 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-7 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-7 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032636 ! interleukin-7 production
-
-[Term]
-id: GO:0072606
-name: interleukin-8 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-8 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-8 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032637 ! interleukin-8 production
-
-[Term]
-id: GO:0072607
-name: interleukin-9 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-9 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-9 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032638 ! interleukin-9 production
-
-[Term]
-id: GO:0072608
-name: interleukin-10 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-10 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-10 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032613 ! interleukin-10 production
-
-[Term]
-id: GO:0072609
-name: interleukin-11 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-11 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-11 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032614 ! interleukin-11 production
-
-[Term]
-id: GO:0072610
-name: interleukin-12 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-12 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "CLMF secretion" NARROW [GOC:BHF]
-synonym: "IL-12 secretion" EXACT [GOC:BHF]
-synonym: "IL12 secretion" EXACT [GOC:BHF]
-synonym: "interleukin-12 complex secretion" EXACT [GOC:BHF]
-synonym: "NKSF secretion" NARROW [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032615 ! interleukin-12 production
-
-[Term]
-id: GO:0072611
-name: interleukin-13 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-13 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-13 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032616 ! interleukin-13 production
-
-[Term]
-id: GO:0072612
-name: interleukin-14 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-14 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-14 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032617 ! interleukin-14 production
-
-[Term]
-id: GO:0072613
-name: interleukin-15 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-15 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-15 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032618 ! interleukin-15 production
-
-[Term]
-id: GO:0072614
-name: interleukin-16 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-16 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-16 secretion" EXACT [GOC:BHF]
-synonym: "IL16 secretion" EXACT [GOC:BHF]
-synonym: "LCF secretion" NARROW [GOC:BHF]
-synonym: "pro-interleukin-16 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032619 ! interleukin-16 production
-
-[Term]
-id: GO:0072615
-name: interleukin-17 secretion
-namespace: biological_process
-def: "The regulated release of any member of the interleukin-17 family of cytokines from a cell." [GOC:add, GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "CTLA-8 secretion" EXACT [GOC:BHF]
-synonym: "Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:BHF]
-synonym: "IL-17 secretion" EXACT [GOC:BHF]
-synonym: "IL-17A secretion" EXACT [GOC:BHF]
-synonym: "IL17A secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032620 ! interleukin-17 production
-
-[Term]
-id: GO:0072616
-name: interleukin-18 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-18 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IGIF secretion" EXACT [GOC:BHF]
-synonym: "IL-18 secretion" EXACT [GOC:BHF]
-synonym: "IL1F4 secretion" NARROW [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032621 ! interleukin-18 production
-
-[Term]
-id: GO:0072617
-name: interleukin-19 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-19 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-19 secretion" EXACT [GOC:BHF]
-synonym: "ZMDA1 secretion" NARROW [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032622 ! interleukin-19 production
-
-[Term]
-id: GO:0072618
-name: interleukin-20 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-20 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-20 secretion" EXACT [GOC:BHF]
-synonym: "ZCYTO10 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032624 ! interleukin-20 production
-
-[Term]
-id: GO:0072619
-name: interleukin-21 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-21 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-21 secretion" EXACT [GOC:BHF]
-synonym: "IL21 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032625 ! interleukin-21 production
-
-[Term]
-id: GO:0072620
-name: interleukin-22 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-22 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-22 secretion" EXACT [GOC:BHF]
-synonym: "IL22 secretion" EXACT [GOC:BHF]
-synonym: "ILTIF secretion" EXACT [GOC:BHF]
-synonym: "ZCYTO18 secretion" NARROW [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032626 ! interleukin-22 production
-
-[Term]
-id: GO:0072621
-name: interleukin-23 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-23 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-23 secretion" EXACT [GOC:BHF]
-synonym: "IL23 secretion" EXACT [GOC:BHF]
-synonym: "interleukin-23 complex secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032627 ! interleukin-23 production
-
-[Term]
-id: GO:0072622
-name: interleukin-24 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-24 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-24 secretion" EXACT [GOC:BHF]
-synonym: "IL24 secretion" EXACT [GOC:BHF]
-synonym: "MDA7 secretion" EXACT [GOC:BHF]
-synonym: "ST16 secretion" NARROW [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032628 ! interleukin-24 production
-
-[Term]
-id: GO:0072623
-name: interleukin-25 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-25 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-25 secretion" EXACT [GOC:BHF]
-synonym: "IL17E secretion" EXACT [GOC:BHF]
-synonym: "IL25 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032629 ! interleukin-25 production
-
-[Term]
-id: GO:0072624
-name: interleukin-26 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-26 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "AK155 secretion" NARROW [GOC:BHF]
-synonym: "IL-26 secretion" EXACT [GOC:BHF]
-synonym: "IL26 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032630 ! interleukin-26 production
-
-[Term]
-id: GO:0072625
-name: interleukin-27 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-27 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-27 secretion" EXACT [GOC:BHF]
-synonym: "IL27 secretion" EXACT [GOC:BHF]
-synonym: "interleukin-27 complex secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032631 ! interleukin-27 production
-
-[Term]
-id: GO:0072626
-name: interleukin-35 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-35 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-35 secretion" EXACT [GOC:BHF]
-synonym: "IL35 secretion" EXACT [GOC:BHF]
-synonym: "interleukin-35 complex secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0070753 ! interleukin-35 production
-
[Term]
id: GO:0072627
name: interleukin-28A production
namespace: biological_process
-def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
+alt_id: GO:0072628
+def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IL-28A production" EXACT [GOC:BHF]
synonym: "IL28A production" EXACT [GOC:BHF]
synonym: "interferon lambda 2 production" EXACT [GOC:BHF]
+synonym: "interleukin-28A secretion" NARROW []
is_a: GO:0034343 ! type III interferon production
-[Term]
-id: GO:0072628
-name: interleukin-28A secretion
-namespace: biological_process
-def: "The regulated release of interleukin-28A from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-28A secretion" EXACT [GOC:BHF]
-synonym: "IL28A secretion" EXACT [GOC:BHF]
-synonym: "interferon lambda 2 secretion" EXACT [GOC:BHF]
-is_a: GO:0072644 ! type III interferon secretion
-relationship: part_of GO:0072627 ! interleukin-28A production
-
[Term]
id: GO:0072629
name: interleukin-28B production
namespace: biological_process
-def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
+alt_id: GO:0072630
+def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IL-28B production" EXACT [GOC:BHF]
synonym: "IL28B production" EXACT [GOC:BHF]
synonym: "interferon lambda 3 production" EXACT [GOC:BHF]
+synonym: "interleukin-28B secretion" NARROW []
is_a: GO:0034343 ! type III interferon production
-[Term]
-id: GO:0072630
-name: interleukin-28B secretion
-namespace: biological_process
-def: "The regulated release of interleukin-28B from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-28B secretion" EXACT [GOC:BHF]
-synonym: "IL28B secretion" EXACT [GOC:BHF]
-synonym: "interferon lambda 3 secretion" EXACT [GOC:BHF]
-is_a: GO:0072644 ! type III interferon secretion
-relationship: part_of GO:0072629 ! interleukin-28B production
-
[Term]
id: GO:0072631
name: interleukin-29 production
namespace: biological_process
-def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
+alt_id: GO:0072632
+def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IL-29 production" EXACT [GOC:BHF]
synonym: "IL29 production" EXACT [GOC:BHF]
synonym: "interferon lambda 1 production" EXACT [GOC:BHF]
+synonym: "interleukin-29 secretion" NARROW []
is_a: GO:0034343 ! type III interferon production
-[Term]
-id: GO:0072632
-name: interleukin-29 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-29 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-29 secretion" EXACT [GOC:BHF]
-synonym: "IL29 secretion" EXACT [GOC:BHF]
-synonym: "interferon lambda 1 secretion" EXACT [GOC:BHF]
-is_a: GO:0072644 ! type III interferon secretion
-relationship: part_of GO:0072631 ! interleukin-29 production
-
[Term]
id: GO:0072633
name: interleukin-30 production
namespace: biological_process
+alt_id: GO:0072634
def: "The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-30 production" EXACT [GOC:BHF]
synonym: "interleukin-30 complex production" EXACT [GOC:BHF]
+synonym: "interleukin-30 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
-[Term]
-id: GO:0072634
-name: interleukin-30 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-30 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-30 secretion" EXACT [GOC:BHF]
-synonym: "interleukin-30 complex secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0072633 ! interleukin-30 production
-
[Term]
id: GO:0072635
name: interleukin-31 production
namespace: biological_process
+alt_id: GO:0072636
def: "The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
synonym: "IL-31 production" EXACT [GOC:BHF]
+synonym: "interleukin-31 secretion" NARROW []
is_a: GO:0001816 ! cytokine production
-[Term]
-id: GO:0072636
-name: interleukin-31 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-31 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-31 secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0072635 ! interleukin-31 production
-
[Term]
id: GO:0072637
name: interleukin-32 production
namespace: biological_process
-def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
+alt_id: GO:0072638
+alt_id: GO:0150188
+def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:23729669]
synonym: "IL-32 production" EXACT [GOC:BHF]
synonym: "IL32 production" EXACT [GOC:BHF]
+synonym: "interleukin-32 biosynthetic process" NARROW []
+synonym: "interleukin-32 secretion" NARROW []
synonym: "NK4 production" NARROW [GOC:BHF]
synonym: "TAIF production" NARROW [GOC:BHF]
is_a: GO:0001816 ! cytokine production
-
-[Term]
-id: GO:0072638
-name: interleukin-32 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-32 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "IL-32 secretion" EXACT [GOC:BHF]
-synonym: "IL32 secretion" EXACT [GOC:BHF]
-synonym: "NK4 secretion" NARROW [GOC:BHF]
-synonym: "TAIF secretion" NARROW [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0072637 ! interleukin-32 production
+created_by: bc
+creation_date: 2020-02-21T10:26:40Z
[Term]
id: GO:0072639
name: interleukin-33 production
namespace: biological_process
-def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
+alt_id: GO:0072640
+alt_id: GO:0150126
+def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:29778524]
synonym: "C9orf26 production" NARROW [GOC:BHF]
synonym: "IL-33 production" EXACT [GOC:BHF]
synonym: "IL1F11 production" NARROW [GOC:BHF]
synonym: "IL33 production" EXACT [GOC:BHF]
+synonym: "interleukin-33 biosynthetic process" NARROW []
+synonym: "interleukin-33 secretion" NARROW []
synonym: "NF-HEV production" EXACT [GOC:BHF]
is_a: GO:0001816 ! cytokine production
-[Term]
-id: GO:0072640
-name: interleukin-33 secretion
-namespace: biological_process
-def: "The regulated release of interleukin-33 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins]
-synonym: "C9orf26 secretion" NARROW [GOC:BHF]
-synonym: "IL-33 secretion" EXACT [GOC:BHF]
-synonym: "IL1F11 secretion" NARROW [GOC:BHF]
-synonym: "IL33 secretion" EXACT [GOC:BHF]
-synonym: "NF-HEV secretion" EXACT [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0072639 ! interleukin-33 production
-
[Term]
id: GO:0072641
name: type I interferon secretion
@@ -403127,132 +400453,62 @@ synonym: "type I IFN secretion" EXACT [GOC:mah]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032606 ! type I interferon production
-[Term]
-id: GO:0072642
-name: interferon-alpha secretion
-namespace: biological_process
-def: "The regulated release of interferon-alpha from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
-synonym: "IFN-alpha secretion" EXACT [GOC:mah]
-synonym: "IFNA secretion" EXACT [GOC:BHF]
-is_a: GO:0072641 ! type I interferon secretion
-relationship: part_of GO:0032607 ! interferon-alpha production
-
-[Term]
-id: GO:0072643
-name: interferon-gamma secretion
-namespace: biological_process
-def: "The regulated release of interferon-gamma from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
-synonym: "IFN-gamma secretion" EXACT [GOC:mah]
-synonym: "IFNG secretion" EXACT [GOC:BHF]
-synonym: "type II IFN secretion" BROAD [GOC:mah]
-synonym: "type II interferon secretion" BROAD [GOC:BHF]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0032609 ! interferon-gamma production
-
-[Term]
-id: GO:0072644
-name: type III interferon secretion
-namespace: biological_process
-def: "The regulated release of type III interferon from a cell. Interferon lambda is the only member of the type III interferon found so far." [GOC:BHF, GOC:mah, PMID:15546383]
-synonym: "type III IFN secretion" EXACT [GOC:mah]
-is_a: GO:0050663 ! cytokine secretion
-relationship: part_of GO:0034343 ! type III interferon production
-
[Term]
id: GO:0072645
name: interferon-delta production
namespace: biological_process
+alt_id: GO:0072646
def: "The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-delta production" EXACT [GOC:mah]
synonym: "IFND production" EXACT [GOC:BHF]
+synonym: "interferon-delta secretion" NARROW []
is_a: GO:0032606 ! type I interferon production
-[Term]
-id: GO:0072646
-name: interferon-delta secretion
-namespace: biological_process
-def: "The regulated release of interferon-delta from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
-synonym: "IFN-delta secretion" EXACT [GOC:mah]
-synonym: "IFND secretion" EXACT [GOC:BHF]
-is_a: GO:0072641 ! type I interferon secretion
-relationship: part_of GO:0072645 ! interferon-delta production
-
[Term]
id: GO:0072647
name: interferon-epsilon production
namespace: biological_process
+alt_id: GO:0072648
def: "The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-epsilon production" EXACT [GOC:mah]
synonym: "IFNE production" EXACT [GOC:BHF]
+synonym: "interferon-epsilon secretion" NARROW []
is_a: GO:0032606 ! type I interferon production
-[Term]
-id: GO:0072648
-name: interferon-epsilon secretion
-namespace: biological_process
-def: "The regulated release of interferon-epsilon from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
-synonym: "IFN-epsilon secretion" EXACT [GOC:mah]
-synonym: "IFNE secretion" EXACT [GOC:BHF]
-is_a: GO:0072641 ! type I interferon secretion
-relationship: part_of GO:0072647 ! interferon-epsilon production
-
[Term]
id: GO:0072649
name: interferon-kappa production
namespace: biological_process
+alt_id: GO:0072650
def: "The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-kappa production" EXACT [GOC:mah]
synonym: "IFNK production" EXACT [GOC:BHF]
+synonym: "interferon-kappa secretion" NARROW []
is_a: GO:0032606 ! type I interferon production
-[Term]
-id: GO:0072650
-name: interferon-kappa secretion
-namespace: biological_process
-def: "The regulated release of interferon-kappa from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
-synonym: "IFN-kappa secretion" EXACT [GOC:mah]
-synonym: "IFNK secretion" EXACT [GOC:BHF]
-is_a: GO:0072641 ! type I interferon secretion
-relationship: part_of GO:0072649 ! interferon-kappa production
-
[Term]
id: GO:0072651
name: interferon-tau production
namespace: biological_process
+alt_id: GO:0072652
def: "The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-tau production" EXACT [GOC:mah]
+synonym: "IFN-tau secretion" EXACT [GOC:mah]
synonym: "IFNT production" EXACT [GOC:BHF]
+synonym: "interferon-tau secretion" NARROW []
is_a: GO:0032606 ! type I interferon production
-[Term]
-id: GO:0072652
-name: interferon-tau secretion
-namespace: biological_process
-def: "The regulated release of interferon-tau from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
-synonym: "IFN-tau secretion" EXACT [GOC:mah]
-synonym: "IFNT secretion" EXACT [GOC:BHF]
-is_a: GO:0072641 ! type I interferon secretion
-relationship: part_of GO:0072651 ! interferon-tau production
-
[Term]
id: GO:0072653
name: interferon-omega production
namespace: biological_process
+alt_id: GO:0072654
def: "The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383]
synonym: "IFN-omega production" EXACT [GOC:mah]
synonym: "IFNW production" EXACT [GOC:BHF]
+synonym: "interferon-omega secretion" NARROW []
is_a: GO:0032606 ! type I interferon production
-[Term]
-id: GO:0072654
-name: interferon-omega secretion
-namespace: biological_process
-def: "The regulated release of interferon-omega from a cell." [GOC:BHF, GOC:mah, PMID:15546383]
-synonym: "IFN-omega secretion" EXACT [GOC:mah]
-synonym: "IFNW secretion" EXACT [GOC:BHF]
-is_a: GO:0072641 ! type I interferon secretion
-relationship: part_of GO:0072653 ! interferon-omega production
-
[Term]
id: GO:0072655
name: establishment of protein localization to mitochondrion
@@ -403874,8 +401130,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [GOC:mah]
synonym: "response to HU" EXACT [GOC:mah]
is_a: GO:0010033 ! response to organic substance
-is_a: GO:0097327 ! response to antineoplastic agent
-is_a: GO:0097329 ! response to antimetabolite
is_a: GO:1901698 ! response to nitrogen compound
created_by: mah
creation_date: 2012-04-11T04:15:42Z
@@ -403886,7 +401140,6 @@ name: cellular response to hydroxyurea
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [GOC:mah]
synonym: "cellular response to HU" EXACT [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0072710 ! response to hydroxyurea
is_a: GO:1901699 ! cellular response to nitrogen compound
@@ -403901,8 +401154,6 @@ def: "Any process that results in a change in state or activity of a cell or an
synonym: "response to TBZ" EXACT [CHEBI:45979, GOC:mah]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
-is_a: GO:0060992 ! response to fungicide
created_by: mah
creation_date: 2012-04-11T04:23:56Z
@@ -403912,12 +401163,9 @@ name: cellular response to thiabendazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [GOC:mah]
synonym: "cellular response to TBZ" EXACT [CHEBI:45979, GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0072712 ! response to thiabendazole
-is_a: GO:0097237 ! cellular response to toxic substance
created_by: mah
creation_date: 2012-04-11T04:24:19Z
@@ -403966,8 +401214,7 @@ id: GO:0072718
name: response to cisplatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [GOC:mah]
-is_a: GO:0009636 ! response to toxic substance
-is_a: GO:0097327 ! response to antineoplastic agent
+is_a: GO:0042221 ! response to chemical
created_by: mah
creation_date: 2012-04-30T11:31:05Z
@@ -403976,9 +401223,8 @@ id: GO:0072719
name: cellular response to cisplatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
+is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0072718 ! response to cisplatin
-is_a: GO:0097237 ! cellular response to toxic substance
created_by: mah
creation_date: 2012-04-30T11:31:12Z
@@ -404013,7 +401259,6 @@ name: response to amitrole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [GOC:mah]
synonym: "response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah]
-is_a: GO:0009635 ! response to herbicide
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
created_by: mah
@@ -404028,7 +401273,6 @@ synonym: "cellular response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:m
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0072722 ! response to amitrole
-is_a: GO:0097237 ! cellular response to toxic substance
created_by: mah
creation_date: 2012-05-31T10:51:52Z
@@ -404108,7 +401352,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-05-31T11:30:32Z
@@ -404118,7 +401361,6 @@ id: GO:0072731
name: cellular response to papulacandin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [GOC:mah]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0072730 ! response to papulacandin B
@@ -404162,10 +401404,9 @@ id: GO:0072735
name: response to tert-butyl hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [GOC:mah]
-synonym: "response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:365419]
+synonym: "response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090]
synonym: "response to t-BOOH" EXACT [GOC:mah]
is_a: GO:0033195 ! response to alkyl hydroperoxide
-is_a: GO:0046677 ! response to antibiotic
created_by: mah
creation_date: 2012-07-17T10:33:00Z
@@ -404174,9 +401415,8 @@ id: GO:0072736
name: cellular response to tert-butyl hydroperoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [GOC:mah]
-synonym: "cellular response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:365419]
+synonym: "cellular response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090]
synonym: "cellular response to t-BOOH" EXACT [GOC:mah]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071448 ! cellular response to alkyl hydroperoxide
is_a: GO:0072735 ! response to tert-butyl hydroperoxide
@@ -404249,9 +401489,7 @@ id: GO:0072743
name: cellular response to erythromycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:mah]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
is_a: GO:1901323 ! response to erythromycin
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -404263,8 +401501,6 @@ id: GO:0072744
name: cellular response to trichodermin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901324 ! response to trichodermin
@@ -404276,7 +401512,6 @@ id: GO:0072745
name: cellular response to antimycin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:mah]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901325 ! response to antimycin A
@@ -404289,8 +401524,6 @@ id: GO:0072746
name: cellular response to tetracycline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901326 ! response to tetracycline
is_a: GO:1901655 ! cellular response to ketone
@@ -404302,8 +401535,6 @@ id: GO:0072747
name: cellular response to chloramphenicol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901322 ! response to chloramphenicol
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -404317,7 +401548,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus (FK506) stimulus." [GOC:mah]
synonym: "cellular response to FK506" EXACT [CHEBI:61057]
synonym: "cellular response to tacrolimus hydrate" EXACT [CHEBI:61057]
-is_a: GO:0035690 ! cellular response to drug
+is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1901327 ! response to tacrolimus
created_by: mah
creation_date: 2012-08-31T12:34:32Z
@@ -404327,8 +401558,6 @@ id: GO:0072749
name: cellular response to cytochalasin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0036146 ! cellular response to mycotoxin
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901328 ! response to cytochalasin B
@@ -404341,7 +401570,6 @@ id: GO:0072750
name: cellular response to leptomycin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:mah]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901344 ! response to leptomycin B
@@ -404364,8 +401592,6 @@ id: GO:0072752
name: cellular response to rapamycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
@@ -404400,11 +401626,8 @@ id: GO:0072755
name: cellular response to benomyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1901561 ! response to benomyl
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -404416,7 +401639,6 @@ name: cellular response to paraquat
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:mah]
is_a: GO:0071310 ! cellular response to organic substance
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1901562 ! response to paraquat
created_by: mah
creation_date: 2012-11-07T12:08:59Z
@@ -404427,7 +401649,6 @@ name: cellular response to camptothecin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:mah]
synonym: "cellular response to CPT" EXACT [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
@@ -404459,7 +401680,6 @@ id: GO:0072760
name: cellular response to GW 7647
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:mah]
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:1901593 ! response to GW 7647
is_a: GO:1901699 ! cellular response to nitrogen compound
@@ -404484,11 +401704,8 @@ id: GO:0072762
name: cellular response to carbendazim
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1901597 ! response to carbendazim
is_a: GO:1901701 ! cellular response to oxygen-containing compound
created_by: mah
@@ -404511,7 +401728,6 @@ id: GO:0072764
name: cellular response to reversine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:mah]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071415 ! cellular response to purine-containing compound
is_a: GO:1901596 ! response to reversine
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -405057,7 +402273,7 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
is_a: GO:0044127 ! regulation of development of symbiont in host
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host
@@ -408383,6 +405599,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol." [MetaCyc:RXN-9685, PMID:17705488]
xref: EC:5.4.99
xref: MetaCyc:RXN-9685
+xref: RHEA:31987
is_a: GO:0031559 ! oxidosqualene cyclase activity
[Term]
@@ -408400,6 +405617,7 @@ name: (E,E)-geranyllinalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate." [MetaCyc:RXN-10441, PMID:18398052]
xref: MetaCyc:RXN-10441
+xref: RHEA:38155
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
[Term]
@@ -408429,6 +405647,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate." [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047]
xref: EC:4.2.3
xref: MetaCyc:RXN-8414
+xref: RHEA:28294
is_a: GO:0009975 ! cyclase activity
is_a: GO:0010334 ! sesquiterpene synthase activity
@@ -408439,6 +405658,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate." [PMID:12566586, PMID:9442047]
xref: EC:4.2.3
xref: MetaCyc:RXN-8415
+xref: RHEA:31895
is_a: GO:0009975 ! cyclase activity
is_a: GO:0010334 ! sesquiterpene synthase activity
@@ -408463,7 +405683,6 @@ id: GO:0080020
name: regulation of coenzyme A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A." [PMID:18621975]
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0015937 ! coenzyme A biosynthetic process
@@ -408475,10 +405694,7 @@ name: response to benzoic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [PMID:18753285]
synonym: "response to benzoic acid stimulus" EXACT [GOC:dos]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound
[Term]
@@ -408524,7 +405740,6 @@ def: "Any process that results in a change in state or activity of a cell or an
synonym: "response to IBA stimulus" EXACT []
synonym: "response to indole-3-butyric acid stimulus" NARROW []
synonym: "response to indolebutyric acid stimulus" EXACT [GOC:dos]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0009733 ! response to auxin
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
@@ -408597,7 +405812,6 @@ id: GO:0080033
name: response to nitrite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:dhl, PMID:17951451]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -408724,6 +405938,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-galactose + phosphate = L-galactose-1-P + GDP." [EC:2.7.7.69, PMID:18463094]
xref: EC:2.7.7.69
xref: MetaCyc:RXNQT-4141
+xref: RHEA:27698
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity
[Term]
@@ -408733,6 +405948,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP." [PMID:18463094]
xref: EC:2.7.7.78
xref: MetaCyc:RXN-12486
+xref: RHEA:30387
is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity
[Term]
@@ -409219,6 +406435,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimeth
xref: EC:2.1.1.71
xref: KEGG_REACTION:R01320
xref: MetaCyc:RXN4FS-2
+xref: RHEA:32739
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
created_by: dhl
@@ -409435,7 +406652,6 @@ synonym: "adenosine monophosphate transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015868 ! purine ribonucleotide transport
-is_a: GO:0015893 ! drug transport
is_a: GO:0051503 ! adenine nucleotide transport
created_by: dhl
creation_date: 2009-04-28T04:01:37Z
@@ -409645,7 +406861,6 @@ name: regulation of jasmonic acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid." [GOC:dhl]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
-is_a: GO:0032350 ! regulation of hormone metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0009694 ! jasmonic acid metabolic process
relationship: regulates GO:0009694 ! jasmonic acid metabolic process
@@ -409658,7 +406873,6 @@ name: regulation of jasmonic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid." [GOC:dhl]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
-is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0080140 ! regulation of jasmonic acid metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0009695 ! jasmonic acid biosynthetic process
@@ -409672,7 +406886,7 @@ name: regulation of salicylic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid." [GOC:dhl]
is_a: GO:0010337 ! regulation of salicylic acid metabolic process
-is_a: GO:0046885 ! regulation of hormone biosynthetic process
+is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0009697 ! salicylic acid biosynthetic process
relationship: regulates GO:0009697 ! salicylic acid biosynthetic process
@@ -409717,6 +406931,7 @@ xref: EC:4.4.1.1
xref: MetaCyc:LCYSDESULF-RXN
xref: Reactome:R-HSA-1614591 "Excess cysteine yields lanthionine and H2S"
xref: Reactome:R-HSA-1614614 "Cysteine is degraded to serine and H2S"
+xref: RHEA:24931
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: dhl
creation_date: 2010-01-27T04:50:43Z
@@ -409759,6 +406974,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine." [MetaCyc:RXN-6722, PMID:10852939]
synonym: "S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity" EXACT []
xref: MetaCyc:RXN-6722
+xref: RHEA:36099
is_a: GO:0008171 ! O-methyltransferase activity
created_by: dhl
creation_date: 2010-03-26T04:19:39Z
@@ -409771,7 +406987,6 @@ def: "Any process that activates or increases the frequency, rate or extent of s
synonym: "positive regulation of salicylic acid mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway
-is_a: GO:2001040 ! positive regulation of cellular response to drug
relationship: positively_regulates GO:0009863 ! salicylic acid mediated signaling pathway
created_by: dhl
creation_date: 2010-05-20T03:10:46Z
@@ -409919,7 +407134,6 @@ id: GO:0080164
name: regulation of nitric oxide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:DHL]
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process
relationship: regulates GO:0046209 ! nitric oxide metabolic process
@@ -409987,8 +407201,7 @@ namespace: biological_process
def: "The process in which hydrogen peroxide is transported across a membrane." [GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "hydrogen peroxide membrane transport" EXACT []
-is_a: GO:0006855 ! drug transmembrane transport
-is_a: GO:0051181 ! cofactor transport
+is_a: GO:0055085 ! transmembrane transport
created_by: dhl
creation_date: 2010-09-23T05:12:14Z
@@ -411940,10 +409153,11 @@ is_a: GO:0035556 ! intracellular signal transduction
[Term]
id: GO:0089701
-name: U2AF
+name: U2AF complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]
synonym: "U2 accessory factor" EXACT []
+synonym: "U2AF" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005634 ! nucleus
@@ -411969,10 +409183,7 @@ name: L-glutamate transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0006835 ! dicarboxylic acid transport
-is_a: GO:0006836 ! neurotransmitter transport
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
-is_a: GO:0046618 ! drug export
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
[Term]
@@ -411989,7 +409200,6 @@ name: L-ornithine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
-is_a: GO:0046618 ! drug export
is_a: GO:1903352 ! L-ornithine transmembrane transport
[Term]
@@ -411998,7 +409208,6 @@ name: L-lysine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-lysine out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
-is_a: GO:0046618 ! drug export
is_a: GO:1903401 ! L-lysine transmembrane transport
[Term]
@@ -412007,7 +409216,6 @@ name: L-histidine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane." [PMID:21307582]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
-is_a: GO:0046618 ! drug export
is_a: GO:0089709 ! L-histidine transmembrane transport
is_a: GO:1902024 ! L-histidine transport
is_a: GO:1990822 ! basic amino acid transmembrane transport
@@ -412017,7 +409225,6 @@ id: GO:0089709
name: L-histidine transmembrane transport
namespace: biological_process
def: "The directed movement of L-histidine across a membrane." [PMID:21307582]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015801 ! aromatic amino acid transport
is_a: GO:0045117 ! azole transmembrane transport
is_a: GO:0098655 ! cation transmembrane transport
@@ -412043,6 +409250,7 @@ name: UDP-N-acetyl-D-mannosamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+." [EC:1.1.1.336]
xref: EC:1.1.1.336
+xref: RHEA:25780
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -412736,7 +409944,6 @@ id: GO:0090056
name: regulation of chlorophyll metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll." [GOC:dph, GOC:tb]
-is_a: GO:0051193 ! regulation of cofactor metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0015994 ! chlorophyll metabolic process
@@ -417171,7 +414378,6 @@ namespace: molecular_function
def: "Enables the transfer of nicotinate from one side of a membrane to the other." [GOC:tb]
xref: Reactome:R-HSA-8869603 "SLC22A13 transports NCA from extracellular region to cytosol"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
-is_a: GO:0090482 ! vitamin transmembrane transporter activity
relationship: part_of GO:2001142 ! nicotinate transport
created_by: tb
creation_date: 2011-10-19T11:09:59Z
@@ -418073,7 +415279,6 @@ id: GO:0090514
name: L-tyrosine transmembrane import into vacuole
namespace: biological_process
def: "The directed movement of L-tyrosine into the vacuole across the vacuolar membrane." [GOC:al]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015828 ! tyrosine transport
is_a: GO:0032975 ! amino acid transmembrane import into vacuole
is_a: GO:0098655 ! cation transmembrane transport
@@ -418458,8 +415663,8 @@ creation_date: 2013-10-24T16:07:20Z
id: GO:0090555
name: phosphatidylethanolamine flippase activity
namespace: molecular_function
-def: "Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, RHEA:36440]
-comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation.
+def: "Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, PMID:20043909, RHEA:36440]
+comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaftlet of a membrane).
synonym: "ATP-dependent phosphatidylethanolamine transporter activity" RELATED []
synonym: "ATPase-coupled phosphatidylethanolamine transporter activity" BROAD []
synonym: "phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT []
@@ -418516,6 +415721,7 @@ namespace: molecular_function
def: "Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [BRENDA:2.5.1.108, GOC:pde, PMID:15485916]
xref: MetaCyc:RXN-11371
xref: Reactome:R-HSA-5358494 "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2"
+xref: RHEA:36783
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: tb
creation_date: 2014-03-27T14:58:50Z
@@ -419865,18 +417071,6 @@ property_value: RO:0002161 NCBITaxon:4751
created_by: tb
creation_date: 2016-08-25T17:08:33Z
-[Term]
-id: GO:0090699
-name: repair of merotelic kinetochore attachment defect, meiosis I
-namespace: biological_process
-def: "The cell cycle process that corrects the anomalous association of a single chromatid kinetochore with meiotic spindle microtubules emanating from both spindle poles at meiosis I." [GOC:vw, PMID:21920317]
-synonym: "correction of merotelic kinetochore attachment, meiosis I" EXACT []
-is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect
-is_a: GO:1903046 ! meiotic cell cycle process
-relationship: part_of GO:0043060 ! meiotic metaphase I plate congression
-created_by: tb
-creation_date: 2016-08-29T14:03:26Z
-
[Term]
id: GO:0090700
name: maintenance of plant organ identity
@@ -420380,6 +417574,7 @@ def: "Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trim
synonym: "4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity" EXACT []
synonym: "TMTT synthase activity" EXACT []
xref: MetaCyc:RXN-8620
+xref: RHEA:13545
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
created_by: pr
creation_date: 2011-03-16T04:37:20Z
@@ -420900,8 +418095,6 @@ synonym: "L-glutamate biosynthesis" EXACT []
synonym: "L-glutamate formation" EXACT []
synonym: "L-glutamate synthesis" EXACT []
is_a: GO:0006537 ! glutamate biosynthetic process
-is_a: GO:0017144 ! drug metabolic process
-is_a: GO:0042133 ! neurotransmitter metabolic process
created_by: pr
creation_date: 2011-05-24T04:30:38Z
@@ -421055,7 +418248,6 @@ synonym: "response to T4" EXACT [Wikipedia:Thyroxine]
synonym: "response to T4 stimulus" EXACT [Wikipedia:Thyroxine]
synonym: "response to thyroxine stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
is_a: GO:0043200 ! response to amino acid
is_a: GO:0097066 ! response to thyroid hormone
is_a: GO:1904386 ! response to L-phenylalanine derivative
@@ -421068,7 +418260,6 @@ name: cellular response to thyroxine stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872]
synonym: "cellular response to T4 stimulus" EXACT [Wikipedia:Thyroxine]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097067 ! cellular response to thyroid hormone stimulus
@@ -421189,41 +418380,45 @@ creation_date: 2011-06-17T10:03:55Z
[Term]
id: GO:0097081
-name: vascular smooth muscle cell fate commitment
+name: vascular associated smooth muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
+synonym: "vascular smooth muscle cell fate commitment" EXACT []
is_a: GO:0042693 ! muscle cell fate commitment
-relationship: part_of GO:0035886 ! vascular smooth muscle cell differentiation
+relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation
created_by: pr
creation_date: 2011-06-20T03:51:52Z
[Term]
id: GO:0097082
-name: vascular smooth muscle cell fate specification
+name: vascular associated smooth muscle cell fate specification
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
+synonym: "vascular smooth muscle cell fate specification" EXACT []
is_a: GO:0042694 ! muscle cell fate specification
-relationship: part_of GO:0097081 ! vascular smooth muscle cell fate commitment
+relationship: part_of GO:0097081 ! vascular associated smooth muscle cell fate commitment
created_by: pr
creation_date: 2011-06-20T03:56:21Z
[Term]
id: GO:0097083
-name: vascular smooth muscle cell fate determination
+name: vascular associated smooth muscle cell fate determination
namespace: biological_process
def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
+synonym: "vascular smooth muscle cell fate determination" EXACT []
is_a: GO:0007521 ! muscle cell fate determination
-relationship: part_of GO:0097081 ! vascular smooth muscle cell fate commitment
+relationship: part_of GO:0097081 ! vascular associated smooth muscle cell fate commitment
created_by: pr
creation_date: 2011-06-20T04:00:28Z
[Term]
id: GO:0097084
-name: vascular smooth muscle cell development
+name: vascular associated smooth muscle cell development
namespace: biological_process
def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
+synonym: "vascular smooth muscle cell development" EXACT []
is_a: GO:0055001 ! muscle cell development
-relationship: part_of GO:0035886 ! vascular smooth muscle cell differentiation
+relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation
created_by: pr
creation_date: 2011-06-20T04:03:08Z
@@ -421250,17 +418445,19 @@ creation_date: 2011-06-22T11:17:52Z
id: GO:0097087
name: interleukin-17A production
namespace: biological_process
-def: "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000001138, Wikipedia:Interleukin_17]
+alt_id: GO:0150154
+def: "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PMID:27901018]
synonym: "IL-17A production" EXACT []
+synonym: "interleukin-17A biosynthetic process" NARROW []
is_a: GO:0032620 ! interleukin-17 production
-created_by: pr
+created_by: bc
creation_date: 2011-06-23T11:31:10Z
[Term]
id: GO:0097088
name: interleukin-17F production
namespace: biological_process
-def: "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000001142, Wikipedia:Interleukin_17]
+def: "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, Wikipedia:Interleukin_17]
synonym: "IL-17F production" EXACT []
is_a: GO:0032620 ! interleukin-17 production
created_by: pr
@@ -421703,7 +418900,7 @@ creation_date: 2011-08-01T01:47:16Z
id: GO:0097128
name: cyclin D1-CDK4 complex
namespace: cellular_component
-def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026740]
+def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: pr
creation_date: 2011-08-01T01:48:36Z
@@ -421757,7 +418954,7 @@ creation_date: 2011-08-01T01:57:41Z
id: GO:0097134
name: cyclin E1-CDK2 complex
namespace: cellular_component
-def: "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026745]
+def: "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: pr
creation_date: 2011-08-01T01:58:42Z
@@ -421766,7 +418963,7 @@ creation_date: 2011-08-01T01:58:42Z
id: GO:0097135
name: cyclin E2-CDK2 complex
namespace: cellular_component
-def: "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026746]
+def: "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
created_by: pr
creation_date: 2011-08-01T01:59:57Z
@@ -422012,7 +419209,6 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings." [GOC:sjw, PMID:7583672]
synonym: "PCB binding" EXACT []
synonym: "polychlorobiphenyl binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0097159 ! organic cyclic compound binding
created_by: pr
creation_date: 2011-09-23T02:33:22Z
@@ -423010,7 +420206,6 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin." [GOC:sl, PMID:21307292]
synonym: "catechin gallate binding" BROAD []
synonym: "EGCG binding" EXACT []
-is_a: GO:0008144 ! drug binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:0097243 ! flavonoid binding
is_a: GO:1901363 ! heterocyclic compound binding
@@ -423118,6 +420313,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)." [GOC:mw, KEGG_REACTION:R03864, PMID:8394361, PMID:9461497]
synonym: "leukotriene B4 12-hydroxydehydrogenase activity" EXACT []
xref: Reactome:R-HSA-2161567 "LTB4 is oxidised to 12-oxoLTB4 by PTGR1"
+xref: RHEA:50608
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors
created_by: pr
creation_date: 2012-03-07T02:07:41Z
@@ -423251,6 +420447,7 @@ def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopen
synonym: "(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT []
synonym: "2-trans,6-trans-farnesyl diphosphate activity" EXACT []
xref: Reactome:R-HSA-2162253 "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer"
+xref: RHEA:27802
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: pr
creation_date: 2012-03-20T01:00:23Z
@@ -423277,10 +420474,11 @@ creation_date: 2012-03-20T03:39:20Z
[Term]
id: GO:0097272
-name: ammonia homeostasis
+name: ammonium homeostasis
namespace: biological_process
-def: "Any biological process involved in the maintenance of an internal steady state of ammonia." [GOC:yaf, PMID:12695560]
-is_a: GO:0048878 ! chemical homeostasis
+def: "Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]
+synonym: "ammonia homeostasis" EXACT []
+is_a: GO:0055067 ! monovalent inorganic cation homeostasis
created_by: pr
creation_date: 2012-03-22T02:51:22Z
@@ -423304,11 +420502,12 @@ creation_date: 2012-03-22T02:53:39Z
[Term]
id: GO:0097275
-name: cellular ammonia homeostasis
+name: cellular ammonium homeostasis
namespace: biological_process
-def: "Any biological process involved in the maintenance of an internal steady state of ammonia at the level of the cell." [GOC:yaf, PMID:12695560]
-is_a: GO:0055082 ! cellular chemical homeostasis
-is_a: GO:0097272 ! ammonia homeostasis
+def: "Any biological process involved in the maintenance of an internal steady state of ammonium at the level of the cell." [GOC:yaf, PMID:12695560]
+synonym: "cellular ammonia homeostasis" EXACT []
+is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis
+is_a: GO:0097272 ! ammonium homeostasis
created_by: pr
creation_date: 2012-03-22T02:54:38Z
@@ -423670,7 +420869,6 @@ name: response to farnesol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [GOC:pr]
is_a: GO:0033993 ! response to lipid
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:0097305 ! response to alcohol
created_by: pr
creation_date: 2012-05-15T03:51:31Z
@@ -423680,7 +420878,6 @@ id: GO:0097308
name: cellular response to farnesol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [GOC:di, PMID:11425711]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:0097307 ! response to farnesol
@@ -423871,7 +421068,7 @@ id: GO:0097328
name: response to carboplatin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus." [GOC:pr]
-is_a: GO:0097327 ! response to antineoplastic agent
+is_a: GO:0042221 ! response to chemical
created_by: pr
creation_date: 2012-06-12T10:50:34Z
@@ -423891,9 +421088,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." [GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097327 ! response to antineoplastic agent
-is_a: GO:0097329 ! response to antimetabolite
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: pr
creation_date: 2012-06-12T10:53:35Z
@@ -423905,9 +421099,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus." [GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097327 ! response to antineoplastic agent
-is_a: GO:0097329 ! response to antimetabolite
is_a: GO:1903416 ! response to glycoside
created_by: pr
creation_date: 2012-06-12T10:55:29Z
@@ -423928,7 +421119,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus." [GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097332 ! response to antipsychotic drug
created_by: pr
creation_date: 2012-06-12T11:00:04Z
@@ -423940,7 +421130,6 @@ def: "Any process that results in a change in state or activity of a cell or an
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
-is_a: GO:0097332 ! response to antipsychotic drug
created_by: pr
creation_date: 2012-06-12T11:01:14Z
@@ -423951,7 +421140,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus." [GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097332 ! response to antipsychotic drug
created_by: pr
creation_date: 2012-06-12T11:03:22Z
@@ -423962,7 +421150,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus." [GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097332 ! response to antipsychotic drug
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: pr
creation_date: 2012-06-12T11:04:31Z
@@ -423974,7 +421161,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms." [GOC:pr]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097332 ! response to antipsychotic drug
created_by: pr
creation_date: 2012-06-12T11:05:31Z
@@ -423983,10 +421169,8 @@ id: GO:0097338
name: response to clozapine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus." [GOC:pr]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097332 ! response to antipsychotic drug
created_by: pr
creation_date: 2012-06-12T11:07:01Z
@@ -423997,7 +421181,6 @@ namespace: biological_process
def: "The process in which glycolate is transported across a membrane. Glycolate is the anion of hydroxyethanoic acid (glycolic acid)." [GOC:am, PMID:11283302, PMID:11785976]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "glycolate membrane transport" EXACT []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:1900866 ! glycolate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: pr
@@ -424106,6 +421289,7 @@ id: GO:0097350
name: neutrophil clearance
namespace: biological_process
def: "The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms." [GOC:BHF, PMID:21957127]
+is_a: GO:0043277 ! apoptotic cell clearance
is_a: GO:0048771 ! tissue remodeling
relationship: has_part GO:0006909 ! phagocytosis
relationship: part_of GO:0001780 ! neutrophil homeostasis
@@ -424432,6 +421616,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: dIDP + H2O = dIMP + phosphate." [GOC:pde, PMID:20385596]
synonym: "deoxyinosine-diphosphatase activity" EXACT []
xref: Reactome:R-HSA-2509793 "NUDT16 hydrolyses dIDP to dIMP"
+xref: RHEA:35211
is_a: GO:0097382 ! deoxynucleoside-diphosphatase activity
created_by: pr
creation_date: 2012-10-11T16:04:40Z
@@ -429888,7 +427073,7 @@ id: GO:0098600
name: selenomethionine gamma-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid." [PMID:11578145, PMID:16037612, PMID:16444005]
-xref: Reactome:R-HSA-2408537 "Excess SeMet is cleaved into MeSeH by CTH"
+xref: Reactome:R-HSA-2408537 "Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH"
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: dos
creation_date: 2014-04-15T15:00:28Z
@@ -429899,6 +427084,7 @@ name: selenomethionine adenosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine." [PMID:2339986]
xref: Reactome:R-HSA-2408551 "SeMet is converted to AdoSeMet by MAT"
+xref: RHEA:31211
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
created_by: dos
creation_date: 2014-04-15T15:15:03Z
@@ -429936,7 +427122,8 @@ id: GO:0098606
name: selenocystathionine gamma-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid." [PMID:6456763]
-xref: Reactome:R-HSA-2408543 "SeCysta is hydrolysed to Sec by CTH"
+xref: Reactome:R-HSA-2408543 "SeCysta is hydrolysed to Sec by PXLP-K212-CTH"
+xref: RHEA:31151
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: dos
creation_date: 2014-04-16T11:20:00Z
@@ -429946,7 +427133,7 @@ id: GO:0098607
name: methylselenocysteine deselenhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol." [PMID:17451884, PMID:20383543]
-xref: Reactome:R-HSA-2408539 "MeSec is hydrolysed to MeSeH by CTH"
+xref: Reactome:R-HSA-2408539 "MeSec is hydrolysed to MeSeH by PXLP-K212-CTH"
is_a: GO:0016846 ! carbon-sulfur lyase activity
created_by: dos
creation_date: 2014-04-16T11:24:12Z
@@ -430055,7 +427242,7 @@ id: GO:0098621
name: phosphoseryl-selenocysteinyl-tRNA selenium transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid." [PMID:17142313, PMID:19608919]
-xref: Reactome:R-HSA-2408555 "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by SEPSECS tetramer"
+xref: Reactome:R-HSA-2408555 "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer"
is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
@@ -430065,6 +427252,7 @@ name: selenodiglutathione-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + selenodiglutathione + NADPH => gluthathioselenol + glutathione + NADP+." [PMID:1569062]
xref: Reactome:R-HSA-2408542 "GSSeSG is reduced to GSSeH and GSH by GSR"
+xref: RHEA:34927
is_a: GO:0015036 ! disulfide oxidoreductase activity
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
@@ -430140,10 +427328,10 @@ is_a: GO:0098743 ! cell aggregation
id: GO:0098631
name: cell adhesion mediator activity
namespace: molecular_function
-def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell." [Wikipedia:Cell_adhesion]
+def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion]
synonym: "cell adhesion molecule" EXACT []
synonym: "protein binding involved in cell adhesion" EXACT []
-is_a: GO:0005488 ! binding
+is_a: GO:0050839 ! cell adhesion molecule binding
intersection_of: GO:0005488 ! binding
intersection_of: part_of GO:0007155 ! cell adhesion
relationship: part_of GO:0007155 ! cell adhesion
@@ -430155,7 +427343,6 @@ namespace: molecular_function
def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]
synonym: "cell-cell adhesion molecule" EXACT []
synonym: "protein binding involved in cell-cell adhesion" EXACT []
-is_a: GO:0005515 ! protein binding
is_a: GO:0098631 ! cell adhesion mediator activity
intersection_of: GO:0005515 ! protein binding
intersection_of: part_of GO:0098609 ! cell-cell adhesion
@@ -430305,12 +427492,14 @@ is_a: GO:0098644 ! complex of collagen trimers
[Term]
id: GO:0098649
-name: response to peptidyl-dipeptidase A inhibitor
+name: obsolete response to peptidyl-dipeptidase A inhibitor
namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidyl-dipeptidase A inhibitor stimulus." [GOC:dos]
+def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidyl-dipeptidase A inhibitor stimulus." [GOC:dos]
+comment: This term was obsoleted because it does not represent a physiological process.
synonym: "response to ACE inhibitor" NARROW []
synonym: "response to angiotensin-converting enzyme inhibitor" NARROW []
-is_a: GO:0042493 ! response to drug
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19725 xsd:anyURI
+is_obsolete: true
[Term]
id: GO:0098650
@@ -430475,7 +427664,6 @@ namespace: cellular_component
def: "A protein complex that is capable of G protein-coupled serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie]
synonym: "G-protein coupled serotonin receptor complex" EXACT []
is_a: GO:0098665 ! serotonin receptor complex
-is_a: GO:0098878 ! neurotransmitter receptor complex
created_by: dos
creation_date: 2016-12-21T12:28:12Z
@@ -431004,7 +428192,6 @@ def: "The directed movement of L-glutamate from outside of a cell, across the pl
synonym: "L-glutamate import into cell" EXACT []
synonym: "L-glutamate(1-) import across plasma membrane" BROAD []
synonym: "L-glutamate(1-) import into cell" EXACT []
-is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0015813 ! L-glutamate transmembrane transport
is_a: GO:0051938 ! L-glutamate import
is_a: GO:0089718 ! amino acid import across plasma membrane
@@ -431073,14 +428260,9 @@ alt_id: GO:1901688
def: "The directed movement of pantothenate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]
synonym: "pantothenate import" RELATED []
synonym: "pantothenate import into cell" EXACT []
-is_a: GO:0015718 ! monocarboxylic acid transport
-is_a: GO:0035461 ! vitamin transmembrane transport
-is_a: GO:0042886 ! amide transport
-is_a: GO:0051181 ! cofactor transport
-is_a: GO:0072337 ! modified amino acid transport
+is_a: GO:0015887 ! pantothenate transmembrane transport
is_a: GO:0098657 ! import into cell
is_a: GO:0098739 ! import across plasma membrane
-is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: jl
creation_date: 2012-12-06T13:02:23Z
@@ -431618,15 +428800,6 @@ synonym: "mechanically-gated potassium channel activity" EXACT []
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0140135 ! mechanosensitive cation channel activity
-[Term]
-id: GO:0098783
-name: repair of mitotic merotelic kinetochore attachment defect
-namespace: biological_process
-def: "The cell cycle process that corrects the anomalous association of a single chromatid kinetochore with mitotic spindle microtubules emanating from both spindle poles (otherwise known as merotelic attachment to the spindle)." [PMID:21306900]
-synonym: "correction of merotelic kinetochore attachment, mitotic" EXACT []
-synonym: "repair of mitotic merotelic kinetochore attachment defects" EXACT []
-is_a: GO:1990598 ! repair of mitotic mono-orientation defect
-
[Term]
id: GO:0098784
name: biofilm matrix organization
@@ -432153,7 +429326,6 @@ namespace: biological_process
def: "The process in which a folic acid, or one of its derivatives (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) is transported across a membrane." [PMID:24745983]
synonym: "folic acid transmembrane transport" RELATED []
synonym: "reduced folate transmembrane transport" NARROW []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015884 ! folic acid transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
@@ -432260,6 +429432,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane." [EC:4.7.1.1, GOC:dos, GOC:ik]
synonym: "alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming)" EXACT [EC:4.7.1.1]
xref: EC:4.7.1.1
+xref: RHEA:34707
is_a: GO:0018835 ! carbon phosphorus lyase activity
[Term]
@@ -434011,8 +431184,8 @@ is_a: GO:0032507 ! maintenance of protein location in cell
intersection_of: GO:0045185 ! maintenance of protein location
intersection_of: occurs_in GO:0051286 ! cell tip
relationship: occurs_in GO:0051286 ! cell tip
-property_value: http://purl.org/dc/elements/1.1/creator "dos" xsd:string
-property_value: http://purl.org/dc/elements/1.1/date 2016-06-30T15:17:41Z xsd:dateTime
+created_by: dos
+creation_date: 2016-06-30T15:17:41Z
[Term]
id: GO:0099018
@@ -434289,7 +431462,7 @@ creation_date: 2013-01-08T15:07:50Z
id: GO:0099045
name: viral extrusion
namespace: biological_process
-def: "The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded." [PMID:2024582831, VZ:3951]
+def: "The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded." [PMID:15567492, VZ:3951]
xref: VZ:3951
is_a: GO:0046753 ! non-lytic viral release
@@ -436831,7 +434004,7 @@ relationship: regulates GO:0030594 ! neurotransmitter receptor activity
id: GO:0099602
name: neurotransmitter receptor regulator activity
namespace: molecular_function
-def: "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing." [GOC:dos, PMID:12740117, PMID:25172949]
+def: "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing." [GOC:dos, PMID:12740117, PMID:18387948]
is_a: GO:0030545 ! receptor regulator activity
relationship: part_of GO:0099601 ! regulation of neurotransmitter receptor activity
@@ -436957,6 +434130,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+." [GOC:al, GOC:dos]
synonym: "UDP-GlcUA decarboxylase activity" EXACT []
xref: EC:1.1.1.305
+xref: RHEA:24702
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -436968,6 +434142,7 @@ synonym: "10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formy
synonym: "ArnAFT activity" EXACT []
synonym: "UDP-L-Ara4N formyltransferase activity" EXACT []
xref: EC:2.1.2.13
+xref: RHEA:24706
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity
[Term]
@@ -436981,6 +434156,7 @@ synonym: "UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase" EXACT
synonym: "UDP-Ara4O aminotransferase" EXACT []
synonym: "UDP-L-Ara4N transaminase" EXACT []
xref: EC:2.6.1.87
+xref: RHEA:24710
is_a: GO:0008483 ! transaminase activity
[Term]
@@ -436994,6 +434170,7 @@ synonym: "undecaprenyl phosphate-L-Ara4FN transferase activity" EXACT []
synonym: "undecaprenyl-phosphate Ara4FN transferase activity" EXACT []
xref: EC:2.4.2.53
xref: MetaCyc:RXN0-3521
+xref: RHEA:27722
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
[Term]
@@ -438033,6 +435210,7 @@ def: "Catalysis of the hydrolysis of ubiquitin from proteins and other molecules
comment: There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases.
synonym: "deubiquitinase activity" EXACT []
synonym: "ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol" NARROW []
+xref: Reactome:R-HSA-9674127 "USP30 deubiquitinates ATM dimer:Ub-p-PEX5"
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
created_by: mec
@@ -438049,18 +435227,22 @@ is_a: GO:0004721 ! phosphoprotein phosphatase activity
[Term]
id: GO:0101007
-name: negative regulation of transcription from RNA polymerase II promoter in response to salt stress
+name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
-def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec]
-is_a: GO:0061416 ! regulation of transcription from RNA polymerase II promoter in response to salt stress
+def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec]
+comment: This term was obsoleted because it represents a GO-CAM model.
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI
+is_obsolete: true
created_by: mec
[Term]
id: GO:0101008
-name: negative regulation of transcription from RNA polymerase II promoter in response to increased salt
+name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to increased salt
namespace: biological_process
-def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec]
-is_a: GO:0101007 ! negative regulation of transcription from RNA polymerase II promoter in response to salt stress
+def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec]
+comment: This term was obsoleted because it represents a GO-CAM model.
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI
+is_obsolete: true
created_by: mec
[Term]
@@ -438271,6 +435453,7 @@ name: 2-octaprenyl-6-hydroxyphenol methylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine." [EC:2.1.1.222]
xref: MetaCyc:2-OCTAPRENYL-6-OHPHENOL-METHY-RXN
+xref: RHEA:27770
is_a: GO:1990888 ! 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity
[Term]
@@ -438279,6 +435462,7 @@ name: 4-methyl-2-oxopentanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) <=> isovaleryl-CoA(4-) + carbon dioxide + NADH(2-)." [EC:1.2.1.-]
xref: MetaCyc:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN
+xref: RHEA:25177
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -438289,6 +435473,7 @@ def: "Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + a
xref: EC:3.1.1.81
xref: MetaCyc:3.1.1.81-RXN
xref: Reactome:R-HSA-8932633 "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE"
+xref: RHEA:22576
is_a: GO:0046573 ! lactonohydrolase activity
[Term]
@@ -438324,6 +435509,7 @@ name: beta-D-galactose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O <=> ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+." [EC:3.6.3.17]
xref: MetaCyc:ABC-18-RXN
+xref: RHEA:30011
is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity
[Term]
@@ -438336,8 +435522,10 @@ synonym: "thiosulfate transmembrane-transporting ATPase activity" RELATED []
synonym: "thiosulphate ABC transporter activity" EXACT []
xref: EC:7.3.2.3
xref: MetaCyc:ABC-7-RXN
-is_a: GO:0015117 ! thiosulfate transmembrane transporter activity
-is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
+xref: RHEA:29871
+is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity
+is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
+relationship: part_of GO:0015709 ! thiosulfate transport
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14642 xsd:anyURI
[Term]
@@ -438354,15 +435542,18 @@ is_a: GO:0008168 ! methyltransferase activity
id: GO:0102028
name: cystathionine gamma-synthase activity (acts on O-phosphohomoserine)
namespace: molecular_function
-def: "Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate." [EC:2.5.1.-, GOC:pz]
+def: "Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate." [GOC:pz, PMID:5922970, PMID:9531508, RHEA:20397]
+xref: EC:2.5.1.48
xref: MetaCyc:CYSPH-RXN
+xref: RHEA:20397
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
[Term]
id: GO:0102029
name: D-lactate dehydrogenase (quinone) activity
namespace: molecular_function
-def: "Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol." [EC:1.1.5.-, GOC:pz]
+def: "Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol." [GOC:pz, PMID:10944213, PMID:4575624, RHEA:51468]
+xref: EC:1.1.5.12
xref: MetaCyc:DLACTDEHYDROGFAD-RXN
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
@@ -438370,7 +435561,7 @@ is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors,
id: GO:0102030
name: dTDP-L-rhamnose synthetase activity
namespace: molecular_function
-def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+." [EC:1.1.1.-, GOC:pz, MetaCyc:DTDPRHAMSYNTHMULTI-RXN]
+def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+." [GOC:pz]
xref: MetaCyc:DTDPRHAMSYNTHMULTI-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -438392,6 +435583,7 @@ def: "Catalysis of the reaction: long-chain fatty acid + NADPH + H+ + O2 = an om
synonym: "cytochrome P450 fatty acid omega-hydroxylase activity" RELATED []
xref: EC:1.14.13.205
xref: MetaCyc:RXN-16394
+xref: RHEA:56748
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14194 xsd:anyURI
@@ -438399,7 +435591,8 @@ property_value: term_tracker_item https://github.com/geneontology/go-ontology/is
id: GO:0102035
name: isobutyryl-CoA:FAD oxidoreductase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2." [EC:1.3.8.-, GOC:pz, MetaCyc:MEPROPCOA-FAD-RXN]
+def: "Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2." [GOC:pz, PMID:3988734]
+xref: EC:1.3.8.5
xref: MetaCyc:MEPROPCOA-FAD-RXN
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
@@ -438407,16 +435600,17 @@ is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors,
id: GO:0102036
name: methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]." [EC:2.1.1.258, GOC:pz]
+def: "Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]." [EC:2.1.1.258, GOC:pz, PMID:7928975]
xref: EC:2.1.1.258
xref: MetaCyc:METHCOCLTH-RXN
+xref: RHEA:45200
is_a: GO:0008168 ! methyltransferase activity
[Term]
id: GO:0102037
name: 4-nitrotoluene monooxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O." [EC:1.14.13.-, GOC:pz, MetaCyc:R361-RXN]
+def: "Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O." [GOC:pz]
xref: MetaCyc:R361-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -438424,7 +435618,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102038
name: 4-nitrobenzyl alcohol oxidase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide." [EC:1.1.3.-, GOC:pz]
+def: "Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide." [GOC:pz]
xref: MetaCyc:R362-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
@@ -438432,7 +435626,8 @@ is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors,
id: GO:0102039
name: alkylhydroperoxide reductase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H2O + NAD + an alcohol <=> NADH + H+ + an organic hydroperoxide." [EC:1.8.1.-, GOC:pz]
+def: "Catalysis of the reaction: H2O + NAD + an alcohol <=> NADH + H+ + an organic hydroperoxide." [GOC:pz, PMID:12517450]
+xref: EC:1.11.1.26
xref: MetaCyc:R4-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
@@ -438440,7 +435635,7 @@ is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors,
id: GO:0102040
name: fumarate reductase (menaquinone)
namespace: molecular_function
-def: "Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone." [EC:1.3.5.4, GOC:pz]
+def: "Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone." [GOC:pz, PMID:11850430, RHEA:27834]
xref: EC:1.3.5.4
xref: MetaCyc:R601-RXN
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
@@ -438449,9 +435644,10 @@ is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors,
id: GO:0102041
name: 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase
namespace: molecular_function
-def: "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid." [EC:2.5.1.105, GOC:pz]
+def: "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid." [GOC:pz, RHEA:35951]
xref: EC:2.5.1.105
xref: MetaCyc:RXN-10009
+xref: RHEA:35951
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
[Term]
@@ -438468,7 +435664,7 @@ is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors
id: GO:0102043
name: isopentenyl phosphate kinase activity
namespace: molecular_function
-def: "Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-)." [EC:2.7.4.26, GOC:pz]
+def: "Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-)." [GOC:pz, PMID:19928876, RHEA:33963]
xref: EC:2.7.4.26
xref: MetaCyc:RXN-10068
xref: RHEA:33963
@@ -438478,7 +435674,7 @@ is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
id: GO:0102044
name: 3-chlorobenzoate-4,5-oxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [EC:1.14.12.-, GOC:pz]
+def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [GOC:pz]
xref: MetaCyc:RXN-10421
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor
@@ -438486,7 +435682,7 @@ is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102045
name: 3-chlorobenzoate-3,4-oxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor." [EC:1.14.12.-, GOC:pz]
+def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor." [GOC:pz, PMID:8285670]
xref: MetaCyc:RXN-10422
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor
@@ -438494,7 +435690,7 @@ is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102046
name: 3,4-dichlorobenzoate-4,5-oxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [EC:1.14.12.-, GOC:pz]
+def: "Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [GOC:pz, PMID:9322760]
xref: MetaCyc:RXN-10427
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor
@@ -438502,7 +435698,7 @@ is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102047
name: indole-3-acetyl-glycine synthetase activity
namespace: molecular_function
-def: "Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz]
+def: "Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623]
xref: MetaCyc:RXN-10429
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
@@ -438510,7 +435706,7 @@ is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
id: GO:0102048
name: indole-3-acetyl-isoleucine synthetase activity
namespace: molecular_function
-def: "Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz]
+def: "Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623]
xref: MetaCyc:RXN-10430
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
@@ -438518,7 +435714,7 @@ is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
id: GO:0102049
name: indole-3-acetyl-methionine synthetase activity
namespace: molecular_function
-def: "Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz]
+def: "Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623]
xref: MetaCyc:RXN-10431
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
@@ -438550,7 +435746,7 @@ is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
id: GO:0102053
name: (-)-jasmonoyl-isoleucine synthetase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz]
+def: "Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid." [GOC:pz]
xref: MetaCyc:RXN-10435
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds
@@ -438560,6 +435756,7 @@ name: maleylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O <=> H+ + maleate(2-) + pyruvate." [EC:3.7.1.-, GOC:pz]
xref: MetaCyc:RXN-10447
+xref: RHEA:47956
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
[Term]
@@ -438568,6 +435765,7 @@ name: 12-hydroxyjasmonate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate." [EC:2.8.2.-, GOC:pz]
xref: MetaCyc:RXN-10451
+xref: RHEA:52728
is_a: GO:0008146 ! sulfotransferase activity
[Term]
@@ -438576,6 +435774,7 @@ name: 11-hydroxyjasmonate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate." [EC:2.8.2.-, GOC:pz]
xref: MetaCyc:RXN-10453
+xref: RHEA:52732
is_a: GO:0008146 ! sulfotransferase activity
[Term]
@@ -438601,6 +435800,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: prenyl diphosphate + 2 isopentenyl diphosphate <=> 2 diphosphoric acid + 2-cis,6-cis-farnesyl diphosphate." [EC:2.5.1.92, GOC:pz]
xref: EC:2.5.1.92
xref: MetaCyc:RXN-10481
+xref: RHEA:27810
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
[Term]
@@ -438674,6 +435874,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+." [EC:1.3.1.83, GOC:pz]
xref: EC:1.3.1.83
xref: MetaCyc:RXN-10625
+xref: RHEA:26229
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -438693,6 +435894,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD <=> zerumbone + NADH + H+." [EC:1.1.1.326, GOC:pz]
xref: EC:1.1.1.326
xref: MetaCyc:RXN-10629
+xref: RHEA:32327
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -438798,6 +436000,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H+ + rebeccamycin + S-adenosyl-L-homocysteine." [EC:2.1.1.164, GOC:pz]
xref: EC:2.1.1.164
xref: MetaCyc:RXN-10847
+xref: RHEA:27353
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -438918,6 +436121,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ <=> 3-dehydro-6-deoxoteasterone + NADP + H2O." [EC:1.14.14.147, GOC:pz]
xref: EC:1.14.14.147
xref: MetaCyc:RXN-11101
+xref: RHEA:27325
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -438927,6 +436131,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+." [EC:1.1.1.365, GOC:pz]
xref: EC:1.1.1.365
xref: MetaCyc:RXN-11151
+xref: RHEA:26345
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -438964,6 +436169,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate." [EC:6.3.2.11, GOC:pz]
xref: EC:6.3.2.11
xref: MetaCyc:RXN-11222
+xref: RHEA:59568
is_a: GO:0016881 ! acid-amino acid ligase activity
[Term]
@@ -439061,6 +436267,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine <=> gibberellin A9 methyl ester + S-adenosyl-L-homocysteine." [EC:2.1.1.275, GOC:pz]
xref: EC:2.1.1.275
xref: MetaCyc:RXN-11358
+xref: RHEA:36119
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -439138,6 +436345,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O <=> 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium." [EC:3.5.4.32, GOC:pz]
xref: EC:3.5.4.32
xref: MetaCyc:RXN-11455
+xref: RHEA:32067
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
[Term]
@@ -439188,7 +436396,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102134
name: (22S)-22-hydroxy-campesterol C-23 hydroxylase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O." [EC:1.14.13.-, GOC:pz]
+def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O." [GOC:pz]
xref: MetaCyc:RXN-11529
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -439196,7 +436404,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102135
name: (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O." [EC:1.14.13.-, GOC:pz]
+def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O." [GOC:pz]
xref: MetaCyc:RXN-11530
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -439264,6 +436472,7 @@ name: carboxynorspermidine dehydrogenase I activity
namespace: molecular_function
def: "Catalysis of the reaction: carboxynorspermidine + NADP + H2O <=> L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+." [EC:1.5.1.43, GOC:pz]
xref: MetaCyc:RXN-11565
+xref: RHEA:34115
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
[Term]
@@ -439272,6 +436481,7 @@ name: carboxyspermidine dehydrogenase II activity
namespace: molecular_function
def: "Catalysis of the reaction: carboxyspermidine + H2O + NADP <=> L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+." [EC:1.5.1.43, GOC:pz]
xref: MetaCyc:RXN-11566
+xref: RHEA:34111
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
[Term]
@@ -439290,6 +436500,7 @@ name: tricetin O-methytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz]
xref: MetaCyc:RXN-11582
+xref: RHEA:27493
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -439298,6 +436509,7 @@ name: 3'-O-methyltricetin O methyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin." [EC:2.1.1.-, GOC:pz]
xref: MetaCyc:RXN-11583
+xref: RHEA:27497
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -439316,6 +436528,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O <=> (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide." [EC:1.8.3.6, GOC:pz]
xref: EC:1.8.3.6
xref: MetaCyc:RXN-11623
+xref: RHEA:30231
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
[Term]
@@ -439373,7 +436586,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
id: GO:0102157
name: (R)-sulfopropanediol 2-dehydrogenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+." [EC:1.1.1.-, GOC:pz]
+def: "Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+." [GOC:pz, PMID:20150239]
xref: MetaCyc:RXN-11729
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -439414,6 +436627,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: copal-8-ol diphosphate <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O." [EC:4.2.1.133, GOC:pz]
xref: EC:4.2.1.133
xref: MetaCyc:RXN-11772
+xref: RHEA:32703
is_a: GO:0016836 ! hydro-lyase activity
[Term]
@@ -439480,6 +436694,7 @@ name: 5-methyl-phenazine-1-carboxylate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz]
xref: MetaCyc:RXN-11897
+xref: RHEA:49112
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -439488,6 +436703,7 @@ name: pyocyanin hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ <=> pyocyanin + NAD + carbon dioxide + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11898
+xref: RHEA:48976
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439506,6 +436722,7 @@ name: DMNT synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 <=> (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11911
+xref: RHEA:55424
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439514,6 +436731,7 @@ name: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-2
namespace: molecular_function
def: "Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11925
+xref: RHEA:58860
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439522,6 +436740,7 @@ name: 24-methylenecycloartanol 4alpha-methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11926
+xref: RHEA:58836
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439530,6 +436749,7 @@ name: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-
namespace: molecular_function
def: "Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11927
+xref: RHEA:58864
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439538,6 +436758,7 @@ name: 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD <=> cycloeucalenone + NADH + carbon dioxide." [EC:1.1.1.-, GOC:pz]
xref: MetaCyc:RXN-11928
+xref: RHEA:59016
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -439554,6 +436775,7 @@ name: 24-methylenelophenol methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11930
+xref: RHEA:58872
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439562,6 +436784,7 @@ name: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH <=> 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11932
+xref: RHEA:58880
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439570,6 +436793,7 @@ name: 24-ethylidenelophenol 4alpha-methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11935
+xref: RHEA:59032
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439578,6 +436802,7 @@ name: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase acti
namespace: molecular_function
def: "Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11936
+xref: RHEA:59036
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439586,6 +436811,7 @@ name: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-11937
+xref: RHEA:59040
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -439758,7 +436984,7 @@ is_a: GO:0008081 ! phosphoric diester hydrolase activity
id: GO:0102201
name: (+)-2-epi-prezizaene synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid." [EC:4.2.3.-, GOC:pz]
+def: "Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid." [GOC:pz, PMID:20175559, PMID:20201526]
xref: MetaCyc:RXN-12117
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
@@ -439807,6 +437033,7 @@ name: 2-polyprenyl-6-hydroxyphenol methylase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol <=> S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol." [EC:2.1.1.222, GOC:pz]
xref: MetaCyc:RXN-12160
+xref: RHEA:31411
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -439872,6 +437099,7 @@ name: thiocyanate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine <=> methyl thiocyanate + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz]
xref: MetaCyc:RXN-12189
+xref: RHEA:28014
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -439936,6 +437164,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD <=> 4,4'-diapolycopene + 4 FADH2." [EC:1.3.8.2, GOC:pz]
xref: EC:1.3.8.2
xref: MetaCyc:RXN-12224
+xref: RHEA:31391
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
[Term]
@@ -439944,6 +437173,7 @@ name: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epime
namespace: molecular_function
def: "Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+." [EC:3.2.1.-, GOC:pz]
xref: MetaCyc:RXN-12236
+xref: RHEA:46316
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -439952,6 +437182,7 @@ name: 4,4'-diaponeurosporene desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4'-diaponeurosporene + FAD + H+ <=> 4,4'-diapolycopene + FADH2." [EC:1.3.8.-, GOC:pz]
xref: MetaCyc:RXN-12258
+xref: RHEA:31407
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
[Term]
@@ -440074,6 +437305,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: aminodeoxyfutalosinate + H2O <=> dehypoxanthine futalosine + adenine." [EC:3.2.2.30, GOC:pz]
xref: EC:3.2.2.30
xref: MetaCyc:RXN-12346
+xref: RHEA:33079
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
[Term]
@@ -440176,7 +437408,7 @@ is_a: GO:0052689 ! carboxylic ester hydrolase activity
id: GO:0102258
name: 1,3-diacylglycerol acylhydrolase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid." [EC:3.1.1.-, GOC:pz]
+def: "Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid." [GOC:pz, PMID:21477884]
xref: MetaCyc:RXN-12433
is_a: GO:0052689 ! carboxylic ester hydrolase activity
@@ -440184,7 +437416,7 @@ is_a: GO:0052689 ! carboxylic ester hydrolase activity
id: GO:0102259
name: 1,2-diacylglycerol acylhydrolase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid." [EC:3.1.1.-, GOC:pz]
+def: "Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid." [GOC:pz, PMID:1477884]
xref: MetaCyc:RXN-12434
is_a: GO:0052689 ! carboxylic ester hydrolase activity
@@ -440195,6 +437427,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-ol + 2 NADP + H2O <=> germacra-1(10),4,11(13)-trien-12-oate + 2 NADPH + 3 H+." [EC:1.1.1.314, GOC:pz]
xref: EC:1.1.1.314
xref: MetaCyc:RXN-12449
+xref: RHEA:30667
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -440400,6 +437633,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ <=> 11-oxo-beta-amyrin + 3 H2O + 2 NADP." [EC:1.14.14.152, GOC:pz]
xref: EC:1.14.14.152
xref: MetaCyc:RXN-12680
+xref: RHEA:31711
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -440409,6 +437643,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ <=> 11alpha-hydroxy-beta-amyrin + H2O + NADP." [EC:1.14.14.152, GOC:pz]
xref: EC:1.14.14.152
xref: MetaCyc:RXN-12681
+xref: RHEA:31715
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -440418,6 +437653,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP." [EC:1.14.14.152, GOC:pz]
xref: EC:1.14.14.152
xref: MetaCyc:RXN-12682
+xref: RHEA:31719
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -440444,6 +437680,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+." [EC:1.1.1.145, GOC:pz]
xref: EC:1.1.1.145
xref: MetaCyc:RXN-12693
+xref: RHEA:43932
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -440487,6 +437724,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: alpha-linolenate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate." [EC:1.13.11.61, GOC:pz]
xref: EC:1.13.11.61
xref: MetaCyc:RXN-12759
+xref: RHEA:31687
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
[Term]
@@ -440544,6 +437782,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphoric acid." [EC:3.1.7.10, GOC:pz]
xref: EC:3.1.7.10
xref: MetaCyc:RXN-12892
+xref: RHEA:32075
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity
[Term]
@@ -440608,6 +437847,7 @@ name: 4-coumaroyl 2'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz]
xref: MetaCyc:RXN-12963
+xref: RHEA:57868
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
[Term]
@@ -440672,25 +437912,27 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102321
name: 2,2'-hydroxybiphenyl monooxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD." [EC:1.14.13.44, GOC:pz]
+def: "Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD." [GOC:pz]
xref: EC:1.14.13.44
-xref: MetaCyc:RXN-13150
+xref: MetaCyc:MONOMER-17239
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
id: GO:0102322
name: 2-propylphenol monooxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD." [EC:1.14.13.-, GOC:pz]
+def: "Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD." [GOC:pz, RHEA:63524]
xref: MetaCyc:RXN-13151
+xref: RHEA:63524
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
id: GO:0102323
name: 2-isopropylphenol monooxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD." [EC:1.14.13.-, GOC:pz]
+def: "Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD." [GOC:pz, RHEA:63520]
xref: MetaCyc:RXN-13152
+xref: RHEA:63520
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -440705,8 +437947,9 @@ is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ke
id: GO:0102325
name: 2,2',3-trihydroxybiphenyl monooxygenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O." [EC:1.14.13.-, GOC:pz]
+def: "Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O." [GOC:pz, RHEA:63516]
xref: MetaCyc:RXN-13169
+xref: RHEA:63516
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -440780,6 +438023,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP." [EC:2.7.8.36, GOC:pz]
xref: EC:2.7.8.36
xref: MetaCyc:RXN-13269
+xref: RHEA:34515
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups
[Term]
@@ -440929,6 +438173,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine." [EC:2.6.1.96, GOC:pz]
xref: EC:2.6.1.96
xref: MetaCyc:RXN-13328
+xref: RHEA:32267
is_a: GO:0008483 ! transaminase activity
[Term]
@@ -440955,6 +438200,7 @@ name: 11-cis-retinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+." [EC:1.1.1.-, GOC:pz]
xref: MetaCyc:RXN-13363
+xref: RHEA:54912
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -441238,6 +438484,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol." [EC:1.3.1.94, GOC:pz]
xref: EC:1.3.1.94
xref: MetaCyc:RXN-13604
+xref: RHEA:34279
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -441349,8 +438596,9 @@ is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
id: GO:0102405
name: (+)-taxifolin 5'-hydroxylase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O." [EC:1.14.13.-, GOC:pz]
+def: "Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O." [GOC:pz]
xref: MetaCyc:RXN-13718
+xref: RHEA:61116
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -441360,6 +438608,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate <=> coenzyme A + 16-sinapoyloxypalmitate." [EC:2.3.1.188, GOC:pz]
xref: EC:2.3.1.188
xref: MetaCyc:RXN-13728
+xref: RHEA:26470
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -441467,6 +438716,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: omega-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-omega-hydroxy-C22:0-LPA." [EC:2.3.1.198, GOC:pz]
xref: EC:2.3.1.198
xref: MetaCyc:RXN-13803
+xref: RHEA:33559
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -441498,7 +438748,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
id: GO:0102423
name: (+)-sesaminol 2-O-glucosyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+." [EC:2.4.1.-, GOC:pz]
+def: "Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+." [GOC:pz, PMID:18248594, PMID:19561332]
xref: MetaCyc:RXN-13818
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -441557,6 +438807,7 @@ name: alpha-linolenate Delta5 desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-linolenate + O2 + a reduced electron acceptor = coniferonate + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
xref: MetaCyc:RXN-13857
+xref: RHEA:38039
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
[Term]
@@ -441565,6 +438816,7 @@ name: linoleate Delta5 desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 + a reduced electron acceptor = pinolenate + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
xref: MetaCyc:RXN-13858
+xref: RHEA:46236
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
[Term]
@@ -441776,6 +439028,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate." [EC:2.4.1.300, GOC:pz]
xref: EC:2.4.1.300
xref: MetaCyc:RXN-13969
+xref: RHEA:35431
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -441877,6 +439130,7 @@ name: naringenin 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-naringenin + NADPH + O2 <=> 2-hydroxynaringenin + NADP + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-14069
+xref: RHEA:57588
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -441901,6 +439155,7 @@ name: eriodictyol 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ <=> 2-hydroxyeriodictyol + NADP + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-14077
+xref: RHEA:57596
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -441933,6 +439188,7 @@ name: pinocembrin 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ <=> 2,5,7-trihydroxyflavanone + NADP + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-14083
+xref: RHEA:57592
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -442279,7 +439535,8 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102518
name: (11Z)-eicosenoate 14-hydroxylase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O." [EC:1.14.13.-, GOC:pz]
+def: "Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O." [EC:1.14.18.4, GOC:pz, PMID:8784737, PMID:9680976]
+xref: EC:1.14.18.4
xref: MetaCyc:RXN-14488
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -442519,6 +439776,7 @@ name: mannosylglycerate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate." [EC:3.3.2.-, GOC:pz]
xref: MetaCyc:RXN-14900
+xref: RHEA:58456
is_a: GO:0016803 ! ether hydrolase activity
[Term]
@@ -442527,6 +439785,7 @@ name: glucosylglycerate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate <=> alpha-D-glucose + D-glycerate." [EC:3.3.2.-, GOC:pz]
xref: MetaCyc:RXN-14901
+xref: RHEA:32059
is_a: GO:0016803 ! ether hydrolase activity
[Term]
@@ -442545,6 +439804,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol <=> S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+." [EC:2.1.1.295, GOC:pz]
xref: EC:2.1.1.295
xref: MetaCyc:RXN-14917
+xref: RHEA:38007
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -442650,6 +439910,7 @@ name: hydroxyproline O-arbinofuranose transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline." [EC:2.4.2.-, GOC:pz]
xref: MetaCyc:RXN-15011
+xref: RHEA:49472
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
[Term]
@@ -442666,6 +439927,7 @@ name: aurachin C epoxide hydrolase/isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P)." [EC:3.3.2.-, GOC:pz]
xref: MetaCyc:RXN-15030
+xref: RHEA:48728
is_a: GO:0016803 ! ether hydrolase activity
[Term]
@@ -442726,6 +439988,7 @@ name: N-glutamylanilide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+." [EC:3.5.1.-, GOC:pz]
xref: MetaCyc:RXN-15251
+xref: RHEA:50684
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -442778,6 +440041,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP." [EC:2.4.2.51, GOC:pz]
xref: EC:2.4.2.51
xref: MetaCyc:RXN-15326
+xref: RHEA:35443
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
[Term]
@@ -442953,6 +440217,7 @@ name: cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 16beta-hydroxy-beta-amyrin + H2O + NAD(P)." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-15385
+xref: RHEA:55440
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -442987,6 +440252,7 @@ name: cyclooctat-9-en-5,7-diol C18-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ <=> cyclooctatin + H2O + NADP." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-15430
+xref: RHEA:56824
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -442995,6 +440261,7 @@ name: octat-9-en-7-ol 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ <=> cyclooctat-9-en-5,7-diol + H2O + NADP." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-15431
+xref: RHEA:56820
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -443026,7 +440293,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102610
name: (+)-secoisolariciresinol glucosyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+." [EC:2.4.1.-, GOC:pz]
+def: "Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+." [GOC:pz, PMID:24678929]
xref: MetaCyc:RXN-15442
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -443034,7 +440301,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
id: GO:0102611
name: (+)-secoisolariciresinol monoglucoside glucosyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+." [EC:2.4.1.-, GOC:pz]
+def: "Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+." [GOC:pz, PMID:24678929]
xref: MetaCyc:RXN-15443
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -443052,6 +440319,7 @@ name: trimethyluric acid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-15454
+xref: RHEA:48992
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -443068,6 +440336,7 @@ name: ent-cassadiene-C2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ <=> 2alpha-hydroxy-ent-cassadiene + NADP + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-15462
+xref: RHEA:55484
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -443202,7 +440471,8 @@ is_a: GO:0008168 ! methyltransferase activity
id: GO:0102632
name: (S)-nandinine synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (S)-scoulerine + NADPH + H+ + O2 <=> (S)-nandinine + NADP + 2 H2O." [GOC:pz]
+def: "Catalysis of the reaction: (S)-scoulerine + NADPH + H+ + O2 <=> (S)-nandinine + NADP + 2 H2O." [GOC:pz, PMID:17250743, PMID:21094631, RHEA:50364]
+xref: EC:1.14.19.73
xref: MetaCyc:RXN-15538
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated
@@ -443218,7 +440488,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102634
name: 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity
namespace: molecular_function
-def: "Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+." [EC:1.13.12.-, GOC:pz]
+def: "Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+." [GOC:pz, PMID:15701630]
xref: MetaCyc:RXN-15586
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
@@ -443228,6 +440498,7 @@ name: 11-deoxycorticosterone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ <=> 4-pregnen-20,21-diol-3-one + NAD." [EC:1.1.1.-, GOC:pz]
xref: MetaCyc:RXN-15607
+xref: RHEA:47716
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -443276,7 +440547,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp
id: GO:0102641
name: (R)-lactaldehyde dehydrogenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+." [EC:1.1.1.-, GOC:pz]
+def: "Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+." [GOC:pz]
xref: MetaCyc:RXN-15743
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -443388,7 +440659,8 @@ is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidat
id: GO:0102657
name: 1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
+def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:15579662]
+xref: EC:1.14.19.42
xref: MetaCyc:RXN-1728
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
@@ -443433,6 +440705,7 @@ name: malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) <=> acetyl-CoA(4-) + carbon dioxide + NADH(2-)." [EC:1.2.1.-, GOC:pz]
xref: MetaCyc:RXN-2902
+xref: RHEA:22992
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -443573,7 +440846,7 @@ is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors,
id: GO:0102679
name: (5alpha)-campestan-3-one hydroxylase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP." [EC:1.14.13.-, GOC:pz]
+def: "Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP." [GOC:pz, PMID:10377996]
xref: MetaCyc:RXN-4230
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -443599,6 +440872,7 @@ name: N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase ac
namespace: molecular_function
def: "Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O <=> N(6)-dimethylallyladenine + D-ribofuranose 5-phosphate." [EC:3.2.2.-, GOC:pz]
xref: MetaCyc:RXN-4313
+xref: RHEA:48560
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
[Term]
@@ -443731,6 +441005,7 @@ name: 2-methylpropionitrile hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH <=> 2-hydroxy-2-methylpropanenitrile + NADP + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-5082
+xref: RHEA:51964
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -443776,6 +441051,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol <=> H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol." [EC:2.4.1.257, GOC:pz]
xref: EC:2.4.1.257
xref: MetaCyc:RXN-5463
+xref: RHEA:29519
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -443784,6 +441060,7 @@ name: serine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + L-serine <=> ethanolaminium(1+) + carbon dioxide." [EC:4.1.1.-, GOC:pz]
xref: MetaCyc:RXN-5641
+xref: RHEA:45824
is_a: GO:0016831 ! carboxy-lyase activity
[Term]
@@ -443915,6 +441192,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A." [EC:2.3.1.224, GOC:pz]
xref: EC:2.3.1.224
xref: MetaCyc:RXN-6762
+xref: RHEA:36147
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -443966,6 +441244,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose." [EC:3.2.1.182, GOC:pz]
xref: EC:3.2.1.182
xref: MetaCyc:RXN-7082
+xref: RHEA:33975
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
[Term]
@@ -443982,6 +441261,7 @@ name: campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH." [EC:1.3.1.-, GOC:pz]
xref: MetaCyc:RXN-711
+xref: RHEA:54416
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -444055,7 +441335,7 @@ is_a: GO:0016747 ! transferase activity, transferring acyl groups other than ami
id: GO:0102738
name: (gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
-def: "Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz]
+def: "Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate." [GOC:pz]
xref: MetaCyc:RXN-7589
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
@@ -444063,7 +441343,7 @@ is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
id: GO:0102739
name: (gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
-def: "Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide." [EC:1.14.11.-, GOC:pz]
+def: "Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide." [GOC:pz]
xref: MetaCyc:RXN-7591
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
@@ -444074,6 +441354,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: theobromine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine." [EC:2.1.1.160, GOC:pz]
xref: EC:2.1.1.160
xref: MetaCyc:RXN-7599
+xref: RHEA:20944
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -444166,6 +441447,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+." [EC:2.4.1.186, GOC:pz]
xref: EC:2.4.1.186
xref: MetaCyc:RXN-7667
+xref: RHEA:56560
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -444217,6 +441499,7 @@ name: NADPH phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate." [EC:3.1.3.-, GOC:pz]
xref: MetaCyc:RXN-7703
+xref: RHEA:60664
is_a: GO:0016791 ! phosphatase activity
[Term]
@@ -444226,6 +441509,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: NADP(3-) + a very-long-chain 2,3,4-saturated fatty acyl CoA <=> NADPH(4-) + H+ + a very-long-chain trans-2,3-dehydroacyl-CoA." [EC:1.3.1.93, GOC:pz]
xref: EC:1.3.1.93
xref: MetaCyc:RXN-7711
+xref: RHEA:14473
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -444250,6 +441534,7 @@ name: eriodictyol 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + homoeriodictyol + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz]
xref: MetaCyc:RXN-7753
+xref: RHEA:60948
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -444266,6 +441551,7 @@ name: phytyl-P kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate <=> (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate." [EC:2.7.4.-, GOC:pz]
xref: MetaCyc:RXN-7763
+xref: RHEA:38099
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
[Term]
@@ -444301,6 +441587,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine." [EC:2.1.1.231, GOC:pz]
xref: EC:2.1.1.231
xref: MetaCyc:RXN-7777
+xref: RHEA:31743
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -444334,6 +441621,7 @@ name: sphingolipid very long chain fatty acid alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-7796
+xref: RHEA:46512
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -444461,6 +441749,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin." [EC:1.14.19.2, GOC:pz]
xref: EC:1.14.19.2
xref: MetaCyc:RXN-7903
+xref: RHEA:11776
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
[Term]
@@ -444629,6 +441918,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + carbon dioxide." [EC:1.14.11.32, GOC:pz]
xref: EC:1.14.11.32
xref: MetaCyc:RXN-8152
+xref: RHEA:27413
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
[Term]
@@ -444669,6 +441959,7 @@ name: glutarate-semialdehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+." [EC:1.2.1.-, GOC:pz]
xref: MetaCyc:RXN-8182
+xref: RHEA:57832
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -444721,6 +442012,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside <=> H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP." [EC:2.4.1.298, GOC:pz]
xref: EC:2.4.1.298
xref: MetaCyc:RXN-8234
+xref: RHEA:35423
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -444770,6 +442062,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine." [EC:2.1.1.42, GOC:pz]
xref: EC:2.1.1.42
xref: MetaCyc:RXN-8262
+xref: RHEA:55332
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -444786,6 +442079,7 @@ name: UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose <=> H+ + quercetin 3-O-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz]
xref: MetaCyc:RXN-8267
+xref: RHEA:61160
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -444864,7 +442158,8 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
id: GO:0102834
name: 1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
+def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918, PMID:8066133]
+xref: EC:1.14.19.23
xref: MetaCyc:RXN-8294
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
@@ -445122,6 +442417,7 @@ name: di-homo-gamma-linolenate Delta5 desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor <=> arachidonate + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
xref: MetaCyc:RXN-8346
+xref: RHEA:46260
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
[Term]
@@ -445131,6 +442427,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O." [EC:2.8.1.9, GOC:pz]
xref: EC:2.8.1.9
xref: MetaCyc:RXN-8351
+xref: RHEA:42636
is_a: GO:0016783 ! sulfurtransferase activity
[Term]
@@ -445161,7 +442458,8 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
id: GO:0102871
name: 1-16:0-2-18:1-phosphatidylcholine desaturase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 1-16:0-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-palmitoyl-2-linoleoyl-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
+def: "Catalysis of the reaction: 1-16:0-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-palmitoyl-2-linoleoyl-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:475773]
+xref: EC:1.14.19.22
xref: MetaCyc:RXN-8360
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
@@ -445169,7 +442467,8 @@ is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidat
id: GO:0102872
name: 1-16:0-2-18:2-phosphatidylcholine desaturase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
+def: "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:15538555, PMID:8102138]
+xref: EC:1.14.19.25
xref: MetaCyc:RXN-8361
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
@@ -445177,7 +442476,8 @@ is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidat
id: GO:0102873
name: 1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
+def: "Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918, PMID:8066133]
+xref: EC:1.14.19.23
xref: MetaCyc:RXN-8363
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
@@ -445185,7 +442485,8 @@ is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidat
id: GO:0102874
name: 1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
+def: "Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:17064923]
+xref: EC:1.14.19.35
xref: MetaCyc:RXN-8365
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
@@ -445249,7 +442550,7 @@ is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
id: GO:0102881
name: (+)-beta-barbatene synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid." [EC:4.2.3.-, GOC:pz]
+def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid." [GOC:pz, PMID:15918888, PMID:16297850]
xref: MetaCyc:RXN-8421
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
@@ -445342,6 +442643,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone <=> H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP." [EC:2.4.1.286, GOC:pz]
xref: EC:2.4.1.286
xref: MetaCyc:RXN-8455
+xref: RHEA:34295
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -445375,6 +442677,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 9(S)-HPODE <=> colneleate + H2O." [EC:4.2.1.121, GOC:pz]
xref: EC:4.2.1.121
xref: MetaCyc:RXN-8496
+xref: RHEA:28174
is_a: GO:0016836 ! hydro-lyase activity
[Term]
@@ -445383,6 +442686,7 @@ name: colnelenate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate <=> colnelenate + H2O." [EC:4.2.1.121, GOC:pz]
xref: MetaCyc:RXN-8498
+xref: RHEA:28178
is_a: GO:0016836 ! hydro-lyase activity
[Term]
@@ -445391,6 +442695,7 @@ name: abietadienal hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: abietal + NADPH + O2 <=> abietate + NADP + H2O." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-8510
+xref: RHEA:56928
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -445450,6 +442755,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid." [EC:4.2.3.60, GOC:pz]
xref: EC:4.2.3.60
xref: MetaCyc:RXN-8561
+xref: RHEA:28302
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
[Term]
@@ -445469,6 +442775,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (-)-7-epi-alpha-selinene + diphosphoric acid." [EC:4.2.3.86, GOC:pz]
xref: EC:4.2.3.86
xref: MetaCyc:RXN-8609
+xref: RHEA:30383
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
[Term]
@@ -445499,7 +442806,7 @@ is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related subs
id: GO:0102911
name: (-)-secoisolariciresinol dehydrogenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH." [EC:1.1.1.-, GOC:pz]
+def: "Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH." [EC:1.1.1.331, GOC:pz]
xref: MetaCyc:RXN-8680
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -445507,7 +442814,7 @@ is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors,
id: GO:0102912
name: (-)-lactol dehydrogenase activity
namespace: molecular_function
-def: "Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH." [EC:1.1.1.-, GOC:pz]
+def: "Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH." [EC:1.1.1.331, GOC:pz]
xref: MetaCyc:RXN-8681
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
@@ -445517,6 +442824,7 @@ name: 3-aminomethylindole N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz]
xref: MetaCyc:RXN-8686
+xref: RHEA:52268
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -445525,6 +442833,7 @@ name: N-methyl-3-aminomethylindole N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz]
xref: MetaCyc:RXN-8687
+xref: RHEA:52272
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -445598,6 +442907,7 @@ name: phenylpropanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A." [EC:2.3.1.-, GOC:pz]
xref: MetaCyc:RXN-8857
+xref: RHEA:42488
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -445606,6 +442916,7 @@ name: 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = H+ + paclitaxel + coenzyme A." [EC:2.3.1.-, GOC:pz]
xref: MetaCyc:RXN-8859
+xref: RHEA:33687
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -445670,7 +442981,7 @@ is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than
id: GO:0102931
name: (Z,E)-alpha- farnesene synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid." [EC:4.2.3.-, GOC:pz]
+def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid." [GOC:pz, PMID:17140613]
xref: MetaCyc:RXN-8931
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates
@@ -445806,7 +443117,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
id: GO:0102947
name: (+)-delta-cadinene-8-hydroxylase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O." [EC:1.14.13.-, GOC:pz]
+def: "Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O." [GOC:pz]
xref: MetaCyc:RXN-9045
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
@@ -445822,7 +443133,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
id: GO:0102949
name: 1,2-rhamnosyltransferase activity
namespace: molecular_function
-def: "Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor." [EC:2.4.1.-, GOC:pz]
+def: "Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor." [GOC:pz, PMID:15220389]
xref: MetaCyc:RXN-9082
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
@@ -445848,6 +443159,7 @@ name: UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP." [EC:2.4.1.-, GOC:pz]
xref: MetaCyc:RXN-91
+xref: RHEA:57708
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -445883,6 +443195,7 @@ name: UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP." [EC:2.4.1.-, GOC:pz]
xref: MetaCyc:RXN-92
+xref: RHEA:57712
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -445901,6 +443214,7 @@ name: 4,4'-diapophytofluene desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-4,4'-diapophytofluene + FAD + H+ = all-trans-4,4'-diapo-zeta-carotene + FADH2." [EC:1.3.8.-, GOC:pz]
xref: MetaCyc:RXN-9304
+xref: RHEA:31399
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
[Term]
@@ -445909,14 +443223,17 @@ name: 4,4'-diapo-zeta-carotene desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-4,4'-diapo-zeta-carotene + FAD + H+ = 4,4'-diaponeurosporene + FADH2." [EC:1.3.8.-, GOC:pz]
xref: MetaCyc:RXN-9305
+xref: RHEA:31403
is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor
[Term]
id: GO:0102963
name: (S)-corytuberine synthase activity
namespace: molecular_function
-def: "Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O." [EC:1.14.21.-, GOC:pz]
+def: "Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O." [EC:1.14.19.51, GOC:pz, PMID:18230623]
+xref: EC:1.14.19.51
xref: MetaCyc:RXN-9314
+xref: RHEA:51540
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated
[Term]
@@ -445925,6 +443242,7 @@ name: S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine <=> H+ + magnoflorine + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz]
xref: MetaCyc:RXN-9315
+xref: RHEA:51524
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -445934,6 +443252,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol." [EC:1.2.1.84, GOC:pz]
xref: EC:1.2.1.84
xref: MetaCyc:RXN-9344
+xref: RHEA:52716
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
[Term]
@@ -445951,6 +443270,7 @@ name: 10-hydroxygeraniol oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP <=> (6E)-8-hydroxygeranial + NADPH + H+." [EC:1.1.1.-, GOC:pz]
xref: MetaCyc:RXN-9367
+xref: RHEA:32607
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -445959,6 +443279,7 @@ name: 10-hydroxygeranial oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP <=> (6E)-8-oxogeranial + NADPH + H+." [EC:1.1.1.-, GOC:pz]
xref: MetaCyc:RXN-9369
+xref: RHEA:32611
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -445967,6 +443288,7 @@ name: 10-oxogeraniol oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6E)-8-oxogeraniol + NADP <=> (6E)-8-oxogeranial + NADPH + H+." [EC:1.1.1.-, GOC:pz]
xref: MetaCyc:RXN-9370
+xref: RHEA:32615
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -446005,6 +443327,7 @@ def: "Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier
synonym: "norsolorinic acid synthase" EXACT []
xref: EC:2.3.1.221
xref: MetaCyc:RXN-9479
+xref: RHEA:35179
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -446044,6 +443367,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN." [EC:1.14.14.10, GOC:pz]
xref: EC:1.14.14.10
xref: MetaCyc:RXN-9508
+xref: RHEA:31359
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
[Term]
@@ -446062,6 +443386,7 @@ name: homofuraneol oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: homofuraneol + NADP <=> (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+." [EC:1.3.1.-, GOC:pz]
xref: MetaCyc:RXN-9564
+xref: RHEA:53944
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
[Term]
@@ -446086,6 +443411,7 @@ name: UDP-3-dehydro-alpha-D-glucose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-alpha-D-glucose + NAD <=> H+ + UDP-3-keto-alpha-D-glucose + NADH." [EC:1.1.1.-, GOC:pz]
xref: MetaCyc:RXN-9578
+xref: RHEA:35755
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -446114,6 +443440,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor <=> linoleoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.6, GOC:pz]
xref: EC:1.14.19.6
xref: MetaCyc:RXN-9601
+xref: RHEA:25856
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
[Term]
@@ -446132,6 +443459,7 @@ name: palmitoleic acid delta 12 desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
xref: MetaCyc:RXN-9616
+xref: RHEA:45096
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
[Term]
@@ -446140,6 +443468,7 @@ name: 9,12-cis-hexadecadienoic acid delta 15 desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor <=> 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
xref: MetaCyc:RXN-9617
+xref: RHEA:46232
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
[Term]
@@ -446156,6 +443485,7 @@ name: 5-n-alk(en)ylresorcinol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz]
xref: MetaCyc:RXN-9619
+xref: RHEA:26325
is_a: GO:0008168 ! methyltransferase activity
[Term]
@@ -446165,6 +443495,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A." [EC:3.1.2.2, GOC:pz]
xref: EC:3.1.2.2
xref: MetaCyc:RXN-9626
+xref: RHEA:40119
is_a: GO:0016790 ! thiolester hydrolase activity
[Term]
@@ -446173,6 +443504,7 @@ name: 2-methylbutyronitrile hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 <=> H2O + NADP + 2-hydroxy-2-methylbutyronitrile." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-9642
+xref: RHEA:51948
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -446181,6 +443513,7 @@ name: linolenate Delta15 desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz]
xref: MetaCyc:RXN-9667
+xref: RHEA:46408
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
[Term]
@@ -446242,6 +443575,7 @@ name: dimethylsulfoxide oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ <=> sulfonyldimethane + H2O + NADP." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXN-9767
+xref: RHEA:57956
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -446353,6 +443687,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate." [EC:2.4.2.43, GOC:pz]
xref: EC:2.4.2.43
xref: MetaCyc:RXN0-2001
+xref: RHEA:35371
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups
[Term]
@@ -446378,6 +443713,7 @@ name: ITPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ITP + H2O <=> H+ + IDP + hydrogenphosphate." [EC:3.6.1.-, GOC:pz]
xref: MetaCyc:RXN0-5073
+xref: RHEA:28330
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
[Term]
@@ -446395,6 +443731,7 @@ name: fructose-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O <=> beta-D-fructofuranose + hydrogenphosphate." [EC:3.1.3.-, GOC:pz]
xref: MetaCyc:RXN0-5186
+xref: RHEA:35603
is_a: GO:0016791 ! phosphatase activity
[Term]
@@ -446419,6 +443756,7 @@ name: ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + methylglyoxal + NADH = hydroxyacetone + NAD." [EC:1.1.1.-, GOC:pz]
xref: MetaCyc:RXN0-5213
+xref: RHEA:35615
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -446427,6 +443765,7 @@ name: L-Ala-D/L-Glu epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate." [EC:5.1.1.-, GOC:pz]
xref: MetaCyc:RXN0-5228
+xref: RHEA:28394
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives
[Term]
@@ -446435,6 +443774,7 @@ name: tartronate semialdehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate + NAD <=> H+ + 2-hydroxy-3-oxopropanoate + NADH." [EC:1.1.1.-, GOC:pz]
xref: MetaCyc:RXN0-5289
+xref: RHEA:18845
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
[Term]
@@ -446476,6 +443816,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor." [EC:2.8.4.4, GOC:pz]
xref: EC:2.8.4.4
xref: MetaCyc:RXN0-6366
+xref: RHEA:37087
is_a: GO:0035596 ! methylthiotransferase activity
is_a: GO:0140096 ! catalytic activity, acting on a protein
@@ -446501,6 +443842,7 @@ name: 4-hydroxy-L-threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine." [EC:4.1.2.-, GOC:pz]
xref: MetaCyc:RXN0-6563
+xref: RHEA:28779
is_a: GO:0016832 ! aldehyde-lyase activity
[Term]
@@ -446528,6 +443870,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+." [EC:2.3.1.1, GOC:pz]
xref: EC:2.3.1.1
xref: MetaCyc:RXN0-6948
+xref: RHEA:44144
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups
[Term]
@@ -446587,6 +443930,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: 1-ethyladenine + O2 + 2-oxoglutarate(2-) <=> adenine + carbon dioxide + acetaldehyde + succinate." [EC:1.14.11.33, GOC:pz]
xref: EC:1.14.11.33
xref: MetaCyc:RXN0-986
+xref: RHEA:30299
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
[Term]
@@ -446595,6 +443939,7 @@ name: gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberelli
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate <=> gibberellin A15 + carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz]
xref: MetaCyc:RXN1F-162
+xref: RHEA:60776
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
[Term]
@@ -446603,6 +443948,7 @@ name: gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O." [EC:1.14.11.-, GOC:pz]
xref: MetaCyc:RXN1F-163
+xref: RHEA:60780
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
[Term]
@@ -446611,6 +443957,7 @@ name: gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate <=> gibberellin A44 diacid + carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz]
xref: MetaCyc:RXN1F-167
+xref: RHEA:60800
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
[Term]
@@ -446635,6 +443982,7 @@ name: UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose <=> H+ + kaempferol-3-rhamnoside + UDP(3-)." [EC:2.4.1.-, GOC:pz]
xref: MetaCyc:RXN1F-474
+xref: RHEA:61164
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -446675,6 +444023,7 @@ name: inositol phosphorylceramide mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-alpha-D-mannose + an inositol-phospho-alpha hydroxyphytoceramide = H+ + GDP + a mannosyl-inositol-phospho-alpha hydroxyphytoceramide." [EC:2.4.1.-, GOC:pz]
xref: MetaCyc:RXN3O-663
+xref: RHEA:61496
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -446764,6 +444113,7 @@ name: quercetin 3-glucoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose <=> quercetin-3-O-glucoside-7-O-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz]
xref: MetaCyc:RXNQT-4161
+xref: RHEA:61188
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -446772,6 +444122,7 @@ name: quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz]
xref: MetaCyc:RXNQT-4162
+xref: RHEA:61184
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups
[Term]
@@ -446780,6 +444131,7 @@ name: 2-(3'-methylthio)propylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-(3-methylthiopropyl)malate + coenzyme A." [EC:2.3.3.-, GOC:pz]
xref: MetaCyc:RXNQT-4163
+xref: RHEA:25605
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
[Term]
@@ -446788,6 +444140,7 @@ name: methylthiopropylmalate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) <=> 3-(3'-methylthio)propylmalate." [EC:5.4.4.-, GOC:pz]
xref: MetaCyc:RXNQT-4164
+xref: RHEA:50644
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups
[Term]
@@ -446900,6 +444253,7 @@ name: CYP79F1 dihomomethionine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXNQT-4309
+xref: RHEA:32719
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -446908,6 +444262,7 @@ name: CYP79F1 trihomomethionine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime." [EC:1.14.13.-, GOC:pz]
xref: MetaCyc:RXNQT-4310
+xref: RHEA:32723
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
[Term]
@@ -447002,6 +444357,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine <=> D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine." [EC:2.7.1.69, GOC:pz]
xref: EC:2.7.1.69
xref: MetaCyc:TRANS-RXN-167A
+xref: RHEA:37359
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
[Term]
@@ -447016,10 +444372,12 @@ is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
id: GO:0103116
name: ATPase-coupled alpha-D-galactofuranose transporter activity
namespace: molecular_function
-def: "Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+." [GOC:pz]
+def: "Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+." [GOC:pz, PMID:19744923, RHEA:61716]
synonym: "alpha-D-galactofuranose transporter activity" EXACT []
synonym: "ATP-dependent alpha-D-galactofuranose transporter activity" EXACT []
+xref: EC:7.5.2.9
xref: MetaCyc:TRANS-RXN0-491
+xref: RHEA:61716
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
[Term]
@@ -447029,6 +444387,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate." [EC:3.5.1.108, GOC:pz]
xref: EC:3.5.1.108
xref: MetaCyc:UDPACYLGLCNACDEACETYL-RXN
+xref: RHEA:25209
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
[Term]
@@ -447148,12 +444507,13 @@ namespace: molecular_function
alt_id: GO:0140362
def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location." [PMID:25736293, PMID:30840879]
synonym: "BAR domain adaptor" NARROW []
-synonym: "cytoskeletal protein membrane adaptor" EXACT []
-synonym: "cytoskeletal protein membrane adaptor activity" EXACT []
-synonym: "cytoskeletal protein membrane anchor activity" EXACT []
-synonym: "cytoskeletal protein-membrane adaptor activity" EXACT []
+synonym: "cytoskeletal protein membrane adaptor" BROAD []
+synonym: "cytoskeletal protein membrane anchor activity" BROAD []
+synonym: "cytoskeletal protein membrane tether activity" BROAD []
+synonym: "cytoskeletal protein-membrane adaptor activity" BROAD []
synonym: "F-BAR domain adaptor" NARROW []
-synonym: "membrane-cytoskeletal protein anchor activity" EXACT []
+synonym: "membrane-cytoskeletal protein anchor activity" BROAD []
+synonym: "membrane-cytoskeletal protein tether activity" BROAD []
synonym: "microtubule cortical anchor activity" NARROW []
is_a: GO:0008093 ! cytoskeletal anchor activity
is_a: GO:0043495 ! protein-membrane adaptor activity
@@ -447179,6 +444539,7 @@ name: 2-oxoglutaramate amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutaramate + H(2)O = 2-oxoglutarate + NH(3)." [EC:3.5.1.111, PMID:21288482]
xref: EC:3.5.1.111
+xref: RHEA:32963
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
created_by: hjd
creation_date: 2017-04-25T14:10:02Z
@@ -447189,6 +444550,7 @@ name: (4S)-4-hydroxy-2-oxoglutarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.42, GOC:hjd, PMID:1098660, PMID:1339418]
xref: EC:4.1.3.42
+xref: RHEA:35639
is_a: GO:0016833 ! oxo-acid-lyase activity
created_by: hjd
creation_date: 2017-04-25T14:14:58Z
@@ -447435,6 +444797,7 @@ xref: EC:5.4.99.42
xref: EC:5.4.99.44
xref: EC:5.4.99.45
xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN
+xref: RHEA:22376
is_a: GO:0009982 ! pseudouridine synthase activity
is_a: GO:0140101 ! catalytic activity, acting on a tRNA
created_by: hjd
@@ -447767,7 +445130,6 @@ name: regulation of cobalamin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [PMID:29056341]
is_a: GO:0030656 ! regulation of vitamin metabolic process
-is_a: GO:0051193 ! regulation of cofactor metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0009235 ! cobalamin metabolic process
@@ -447848,6 +445210,7 @@ name: dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activ
namespace: molecular_function
def: "Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol." [GOC:ha, PMID:9597543]
xref: EC:2.4.1.256
+xref: RHEA:29543
is_a: GO:0046527 ! glucosyltransferase activity
created_by: hjd
creation_date: 2017-11-28T19:16:37Z
@@ -448095,6 +445458,7 @@ name: 2-keto-3-deoxy-L-rhamnonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde." [EC:4.1.2.53, GOC:imk, PMID:18754683]
xref: EC:4.1.2.53
+xref: RHEA:25784
is_a: GO:0016832 ! aldehyde-lyase activity
created_by: hjd
creation_date: 2018-02-15T16:12:17Z
@@ -448356,7 +445720,6 @@ name: positive regulation of cobalamin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341]
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:0106064 ! regulation of cobalamin metabolic process
is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
@@ -448371,7 +445734,6 @@ name: negative regulation of cobalamin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341]
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:0106064 ! regulation of cobalamin metabolic process
is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
@@ -448551,6 +445913,7 @@ comment: The m(1)A modification at position 645 in the large rRNA is highly cons
synonym: "25S rRNA (adenine(645)-N(1))-methyltransferase" EXACT [EC:2.1.1.287]
synonym: "25S rRNA m(1)A(645) methyltransferase" EXACT [EC:2.1.1.287]
xref: EC:2.1.1.287
+xref: RHEA:43792
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity
created_by: hjd
creation_date: 2018-08-22T20:13:21Z
@@ -448798,9 +446161,8 @@ name: spindle pole body-nuclear membrane anchor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body." [GOC:vw, PMID:9763447]
synonym: "nuclear membrane-spindle pole body anchor activity" EXACT []
-synonym: "spindle pole body anchor" EXACT []
synonym: "spindle pole body nuclear membrane anchor activity" EXACT []
-is_a: GO:0043495 ! protein-membrane adaptor activity
+is_a: GO:0140475 ! spindle pole body anchor activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19119 xsd:anyURI
created_by: hjd
creation_date: 2019-01-18T15:57:42Z
@@ -449275,8 +446637,6 @@ name: pyocyanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrocyanin, an iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group." [PMID:28715477]
synonym: "pyocyanin biosynthetic process" EXACT []
-is_a: GO:0009403 ! toxin biosynthetic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
@@ -449560,7 +446920,7 @@ creation_date: 2020-02-18T17:51:43Z
id: GO:0106250
name: DNA-binding transcription repressor activity, RNA polymerase III-specific
namespace: molecular_function
-def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase III-transcribed gene to repress or decrease transcription." [GOC:vw, PMID:15590667, PMID:31833215]
+def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase III-transcribed gene to repress or decrease transcription." [GOC:txnOH-2018, PMID:15590667, PMID:31833215]
is_a: GO:0001217 ! DNA-binding transcription repressor activity
created_by: hjd
creation_date: 2020-02-19T19:34:18Z
@@ -449648,6 +447008,227 @@ is_a: GO:0044001 ! migration in host
created_by: hjd
creation_date: 2020-05-01T14:09:35Z
+[Term]
+id: GO:0106260
+name: double-stranded DNA bridging
+namespace: molecular_function
+def: "The binding activity of a molecule that interacts selectively and non-covalently with two or more regions of double-stranded DNA simultaneously. The binding may be inter- or intramolecular with respect to the DNA." [GOC:mah, PMID:30626735]
+synonym: "dsDNA bridging" EXACT []
+is_a: GO:0003690 ! double-stranded DNA binding
+created_by: hjd
+creation_date: 2020-05-07T19:53:35Z
+
+[Term]
+id: GO:0106261
+name: tRNA uridine(34) acetyltransferase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine." [PMID:25151136, PMID:30733442, RHEA:61020]
+xref: RHEA:61020
+is_a: GO:0016407 ! acetyltransferase activity
+created_by: hjd
+creation_date: 2020-05-08T15:21:51Z
+
+[Term]
+id: GO:0106262
+name: 1-acylglycerophosphoethanolamine O-acyltransferase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA." [PMID:18287005, RHEA:32995]
+is_a: GO:0008374 ! O-acyltransferase activity
+created_by: hjd
+creation_date: 2020-05-18T15:09:57Z
+
+[Term]
+id: GO:0106263
+name: 1-acylglycerophosphoserine O-acyltransferase activity
+namespace: molecular_function
+def: "Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA." [PMID:18287005, RHEA:33191]
+is_a: GO:0008374 ! O-acyltransferase activity
+created_by: hjd
+creation_date: 2020-05-18T15:12:42Z
+
+[Term]
+id: GO:0106264
+name: protein serine kinase activity (using GTP as donor)
+namespace: molecular_function
+def: "Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]." [GOC:sp, PMID:32322062, Rhea:64020]
+is_a: GO:0004672 ! protein kinase activity
+created_by: hjd
+creation_date: 2020-05-28T18:51:18Z
+
+[Term]
+id: GO:0106265
+name: THPH synthase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA." [PMID:9446571]
+synonym: "polyketide syntase" RELATED []
+is_a: GO:0003824 ! catalytic activity
+created_by: hjd
+creation_date: 2020-06-02T18:05:33Z
+
+[Term]
+id: GO:0106266
+name: 3-chloro THPH synthase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O." [PMID:20231486]
+is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
+created_by: hjd
+creation_date: 2020-06-02T18:13:44Z
+
+[Term]
+id: GO:0106267
+name: 3,5 dichloro-THPH synthase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O." [PMID:20231486]
+is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
+created_by: hjd
+creation_date: 2020-06-02T18:16:23Z
+
+[Term]
+id: GO:0106268
+name: 3,5-dichloro-THPH methyl transferase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine." [PMID:20231486]
+synonym: "DIF-1 syntase" RELATED []
+is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
+created_by: hjd
+creation_date: 2020-06-02T18:25:03Z
+
+[Term]
+id: GO:0106271
+name: D-arabinose 1-dehydrogenase (NADP+) activity
+namespace: molecular_function
+def: "Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH." [RHEA:21892]
+xref: EC:1.1.1.117
+xref: RHEA:21892
+is_a: GO:0045290 ! D-arabinose 1-dehydrogenase [NAD(P)+] activity
+created_by: hjd
+creation_date: 2020-06-23T18:47:25Z
+
+[Term]
+id: GO:0106272
+name: protein localization to ERGIC
+namespace: biological_process
+def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059]
+is_a: GO:0034067 ! protein localization to Golgi apparatus
+created_by: hjd
+creation_date: 2020-07-01T17:04:35Z
+
+[Term]
+id: GO:0106273
+name: cytosol to ERGIC protein transport
+namespace: biological_process
+def: "The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059]
+is_a: GO:0015031 ! protein transport
+created_by: hjd
+creation_date: 2020-07-01T17:28:07Z
+
+[Term]
+id: GO:0106274
+name: NAD+-protein-arginine ADP-ribosyltransferase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [RHEA:19149]
+xref: EC:2.4.2.31
+xref: RHEA:19149
+is_a: GO:0003956 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity
+created_by: hjd
+creation_date: 2020-07-02T01:37:02Z
+
+[Term]
+id: GO:0106275
+name: NADP+-protein-arginine ADP-ribosyltransferase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: NADP+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [RHEA:54884]
+xref: EC:2.4.2.31
+xref: RHEA:54884
+is_a: GO:0003956 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity
+created_by: hjd
+creation_date: 2020-07-02T01:39:04Z
+
+[Term]
+id: GO:0106276
+name: biliberdin reductase NAD+ activity
+namespace: molecular_function
+def: "Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+." [RHEA:15797]
+xref: EC:1.3.1.24
+xref: RHEA:15797
+is_a: GO:0004074 ! biliverdin reductase (NAD(P)+) activity
+created_by: hjd
+creation_date: 2020-07-02T01:48:07Z
+
+[Term]
+id: GO:0106277
+name: biliverdin reductase (NADP+) activity
+namespace: molecular_function
+def: "Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+." [RHEA:15793]
+xref: EC:1.3.1.24
+xref: RHEA:15793
+is_a: GO:0004074 ! biliverdin reductase (NAD(P)+) activity
+created_by: hjd
+creation_date: 2020-07-02T01:50:24Z
+
+[Term]
+id: GO:0106278
+name: regulation of UDP-N-acetylglucosamine biosynthetic process
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of the UDP-N_acetylglucosamine biosynthetic process." [PMID:32579556]
+synonym: "regulation of UDP-GlcNAc biosynthetic process" RELATED []
+synonym: "regulation of UDP-N-acetylglucosamine anabolism" RELATED []
+synonym: "regulation of UDP-N-acetylglucosamine biosynthesis" RELATED []
+synonym: "regulation of UDP-N-acetylglucosamine formation" RELATED []
+synonym: "regulation of UDP-N-acetylglucosamine synthesis" RELATED []
+is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
+is_a: GO:0031326 ! regulation of cellular biosynthetic process
+is_a: GO:0051174 ! regulation of phosphorus metabolic process
+is_a: GO:0062012 ! regulation of small molecule metabolic process
+intersection_of: GO:0065007 ! biological regulation
+intersection_of: regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process
+relationship: regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process
+created_by: hjd
+creation_date: 2020-07-09T17:20:49Z
+
+[Term]
+id: GO:0106279
+name: negative regulation of UDP-N-acetylglucosamine biosynthetic process
+namespace: biological_process
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process." [PMID:32579556]
+synonym: "negative regulation of UDP-GlcNAc biosynthesis" RELATED []
+synonym: "negative regulation of UDP-GlcNAc biosynthetic process" RELATED []
+synonym: "negative regulation of UDP-N-acetylglucosamine anabolism" RELATED []
+synonym: "negative regulation of UDP-N-acetylglucosamine biosynthesis" RELATED []
+synonym: "negative regulation of UDP-N-acetylglucosamine formation" RELATED []
+synonym: "negative regulation of UDP-N-acetylglucosamine synthesis" RELATED []
+is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
+is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
+is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
+is_a: GO:0062014 ! negative regulation of small molecule metabolic process
+is_a: GO:0106278 ! regulation of UDP-N-acetylglucosamine biosynthetic process
+intersection_of: GO:0065007 ! biological regulation
+intersection_of: negatively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process
+relationship: negatively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process
+created_by: hjd
+creation_date: 2020-07-09T17:26:06Z
+
+[Term]
+id: GO:0106280
+name: positive regulation of UDP-N-acetylglucosamine biosynthetic process
+namespace: biological_process
+def: "Any process that activates or increases the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process." [PMID:32579556]
+synonym: "positive egulation of UDP-N-acetylglucosamine formation" RELATED []
+synonym: "positive regulation of UDP-GlcNAc biosynthetic process" RELATED []
+synonym: "positive regulation of UDP-N-acetylglucosamine anabolism" RELATED []
+synonym: "positive regulation of UDP-N-acetylglucosamine biosynthesis" RELATED []
+synonym: "positive regulation of UDP-N-acetylglucosamine synthesis" RELATED []
+is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
+is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
+is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
+is_a: GO:0062013 ! positive regulation of small molecule metabolic process
+is_a: GO:0106278 ! regulation of UDP-N-acetylglucosamine biosynthetic process
+intersection_of: GO:0065007 ! biological regulation
+intersection_of: positively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process
+relationship: positively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process
+created_by: hjd
+creation_date: 2020-07-09T18:12:08Z
+
[Term]
id: GO:0110001
name: toxin-antitoxin complex
@@ -451167,6 +448748,7 @@ id: GO:0110134
name: meiotic drive
namespace: biological_process
def: "A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis." [GOC:mah, PMID:26920473, PMID:29322557, PMID:29499907]
+subset: goslim_pombe
is_a: GO:0022414 ! reproductive process
created_by: kmv
creation_date: 2019-01-02T17:37:09Z
@@ -451385,8 +448967,9 @@ creation_date: 2019-06-10T18:18:01Z
id: GO:0110152
name: RNA NAD-cap (NAD-forming) hydrolase activity
namespace: molecular_function
-def: "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)." [GOC:sp, PMID:28283058]
+def: "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)." [GOC:sp, PMID:28283058, RHEA:60880]
comment: This reaction specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
+xref: RHEA:60880
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
created_by: kmv
creation_date: 2019-07-08T15:55:11Z
@@ -451454,7 +449037,7 @@ creation_date: 2019-07-15T18:30:51Z
id: GO:0110159
name: regulation of mitotic spindle formation (spindle phase one)
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw]
+def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw, PMID:27697865]
is_a: GO:0032888 ! regulation of mitotic spindle elongation
is_a: GO:1901673 ! regulation of mitotic spindle assembly
intersection_of: GO:0065007 ! biological regulation
@@ -451467,7 +449050,7 @@ creation_date: 2019-08-12T15:10:26Z
id: GO:0110160
name: negative regulation of mitotic spindle formation (spindle phase one)
namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw]
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw]
is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one)
is_a: GO:1902845 ! negative regulation of mitotic spindle elongation
is_a: GO:1905831 ! negative regulation of spindle assembly
@@ -451481,7 +449064,7 @@ creation_date: 2019-08-12T15:18:32Z
id: GO:0110161
name: positive regulation of mitotic spindle formation (spindle phase one)
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw]
+def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw]
is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one)
is_a: GO:1902846 ! positive regulation of mitotic spindle elongation
is_a: GO:1905832 ! positive regulation of spindle assembly
@@ -451495,7 +449078,7 @@ creation_date: 2019-08-12T15:21:08Z
id: GO:0110162
name: regulation of mitotic spindle elongation (spindle phase three)
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of mitotic spindle elongation (spindle phase three)." [GOC:vw, PMID:27697865]
+def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three)." [GOC:vw, PMID:27697865]
is_a: GO:0032888 ! regulation of mitotic spindle elongation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061805 ! mitotic spindle elongation (spindle phase three)
@@ -451507,7 +449090,7 @@ creation_date: 2019-08-12T15:26:01Z
id: GO:0110163
name: negative regulation of mitotic spindle elongation (spindle phase three)
namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation (spindle phase three)." [GOC:vw, PMID:27697865]
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three)." [GOC:vw, PMID:27697865]
is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three)
is_a: GO:1902845 ! negative regulation of mitotic spindle elongation
intersection_of: GO:0065007 ! biological regulation
@@ -451520,7 +449103,7 @@ creation_date: 2019-08-12T15:29:43Z
id: GO:0110164
name: positive regulation of mitotic spindle elongation (spindle phase three)
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation (spindle phase three)." [GOC:vw, PMID:27697865]
+def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three)." [GOC:vw, PMID:27697865]
is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three)
is_a: GO:1902846 ! positive regulation of mitotic spindle elongation
intersection_of: GO:0065007 ! biological regulation
@@ -451750,6 +449333,13 @@ def: "Removes cholesterol from a membrane or a monolayer lipid particle, transpo
synonym: "cholesterol carrier activity" EXACT []
synonym: "cholesterol transporter activity" BROAD []
synonym: "intermembrane cholesterol transfer activity" NARROW []
+xref: Reactome:R-HSA-1454928 "ABCG4 may mediate cholesterol efflux"
+xref: Reactome:R-HSA-216723 "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane"
+xref: Reactome:R-HSA-265443 "NPC1L1-mediated cholesterol uptake"
+xref: Reactome:R-HSA-265545 "NPC1L1-mediated phytosterol uptake"
+xref: Reactome:R-HSA-266082 "ABCG1-mediated transport of intracellular cholesterol to the cell surface"
+xref: Reactome:R-HSA-5682111 "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane"
+xref: Reactome:R-HSA-8951850 "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane"
is_a: GO:0120015 ! sterol transfer activity
relationship: has_part GO:0015485 ! cholesterol binding
created_by: krc
@@ -452624,31 +450214,34 @@ creation_date: 2017-10-10T15:31:40Z
[Term]
id: GO:0120104
-name: actomyosin contractile ring, proximal layer
+name: mitotic actomyosin contractile ring, proximal layer
namespace: cellular_component
-def: "The region of the actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located." [GOC:krc, GOC:vw, PMID:28914606]
+def: "The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located." [GOC:krc, GOC:vw, PMID:28914606]
+synonym: "actomyosin contractile ring, proximal layer" EXACT []
is_a: GO:0110165 ! cellular anatomical entity
-relationship: part_of GO:0005826 ! actomyosin contractile ring
+relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring
created_by: krc
creation_date: 2017-10-11T22:49:58Z
[Term]
id: GO:0120105
-name: actomyosin contractile ring, intermediate layer
+name: mitotic actomyosin contractile ring, intermediate layer
namespace: cellular_component
-def: "The region of the actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer." [GOC:krc, GOC:vw, PMID:28914606]
+def: "The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer." [GOC:krc, GOC:vw, PMID:28914606]
+synonym: "actomyosin contractile ring, intermediate layer" EXACT []
is_a: GO:0110165 ! cellular anatomical entity
-relationship: part_of GO:0005826 ! actomyosin contractile ring
+relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring
created_by: krc
creation_date: 2017-10-11T22:54:40Z
[Term]
id: GO:0120106
-name: actomyosin contractile ring, distal actin filament layer
+name: mitotic actomyosin contractile ring, distal actin filament layer
namespace: cellular_component
-def: "The region of the actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to." [GOC:krc, GOC:vw, PMID:28914606]
+def: "The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to." [GOC:krc, GOC:vw, PMID:28914606]
+synonym: "actomyosin contractile ring, distal actin filament layer" EXACT []
is_a: GO:0110165 ! cellular anatomical entity
-relationship: part_of GO:0005826 ! actomyosin contractile ring
+relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring
created_by: krc
creation_date: 2017-10-11T22:56:44Z
@@ -452669,6 +450262,7 @@ namespace: molecular_function
def: "Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H(2)O <=> (DNA)-3'-phosphate + GMP." [PMID:26007660]
synonym: "DNA-3'pp5'G guanylate hydrolase" EXACT []
xref: EC:3.1.12.2
+xref: RHEA:52140
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds
created_by: krc
creation_date: 2017-10-17T22:12:59Z
@@ -452840,7 +450434,7 @@ creation_date: 2018-01-29T19:28:56Z
id: GO:0120124
name: membrane fusion priming complex
namespace: cellular_component
-def: "A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes." [GOC:lnp, PMID:90153011]
+def: "A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes." [GOC:lnp, PMID:9015301]
synonym: "GATE-16 complex" EXACT []
synonym: "LMA1 complex" EXACT []
xref: IntAct:EBI-16411729
@@ -453595,6 +451189,7 @@ id: GO:0120188
name: regulation of bile acid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]
+is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0051046 ! regulation of secretion
@@ -453609,6 +451204,7 @@ id: GO:0120189
name: positive regulation of bile acid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]
+is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0120188 ! regulation of bile acid secretion
@@ -453624,6 +451220,7 @@ id: GO:0120190
name: negative regulation of bile acid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]
+is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0120188 ! regulation of bile acid secretion
@@ -454091,6 +451688,126 @@ relationship: part_of GO:0060541 ! respiratory system development
created_by: krc
creation_date: 2020-02-24T17:13:10Z
+[Term]
+id: GO:0120225
+name: coenzyme A binding
+namespace: molecular_function
+def: "Interacting selectively and non-covalently with coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:krc, ISBN:0198547684]
+synonym: "CoA binding" EXACT []
+is_a: GO:0032559 ! adenyl ribonucleotide binding
+is_a: GO:0043168 ! anion binding
+created_by: krc
+creation_date: 2020-05-06T18:22:56Z
+
+[Term]
+id: GO:0120226
+name: succinyl-CoA binding
+namespace: molecular_function
+def: "Interacting selectively and non-covalently with succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component." [GOC:krc]
+synonym: "succinyl-coenzyme A binding" EXACT []
+is_a: GO:0120227 ! acyl-CoA binding
+created_by: krc
+creation_date: 2020-05-19T15:51:32Z
+
+[Term]
+id: GO:0120227
+name: acyl-CoA binding
+namespace: molecular_function
+def: "Interacting selectively and non-covalently with an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid." [GOC:krc]
+synonym: "acyl binding" BROAD []
+synonym: "acyl-coenzyme A binding" EXACT []
+is_a: GO:0032559 ! adenyl ribonucleotide binding
+is_a: GO:0033218 ! amide binding
+is_a: GO:0043168 ! anion binding
+is_a: GO:1901681 ! sulfur compound binding
+created_by: krc
+creation_date: 2020-05-19T16:06:24Z
+
+[Term]
+id: GO:0120228
+name: outer dynein arm docking complex
+namespace: cellular_component
+def: "A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules." [GOC:krc, PMID:15064350, PMID:24067530, PMID:25192045, PMID:27486780, PMID:8045937]
+synonym: "ODA docking complex" RELATED [PMID:27486780]
+synonym: "ODA-DC" RELATED [PMID:27486780]
+is_a: GO:0032991 ! protein-containing complex
+relationship: part_of GO:0005930 ! axoneme
+created_by: krc
+creation_date: 2020-06-05T23:30:44Z
+
+[Term]
+id: GO:0120229
+name: protein localization to motile cilium
+namespace: biological_process
+def: "A process in which a protein is transported to, or maintained in, a location within a motile cilium." [GOC:krc, PMID:27486780]
+synonym: "protein localization to nonmotile primary cilium" RELATED []
+is_a: GO:0061512 ! protein localization to cilium
+created_by: krc
+creation_date: 2020-06-05T23:43:04Z
+
+[Term]
+id: GO:0120230
+name: recombinase activator activity
+namespace: molecular_function
+def: "Binds to and increases the activity of a recombinase." [GOC:mah, PMID:32414915]
+is_a: GO:0008047 ! enzyme activator activity
+created_by: krc
+creation_date: 2020-06-18T15:54:26Z
+
+[Term]
+id: GO:0120231
+name: DNA recombinase auxiliary factor complex
+namespace: cellular_component
+def: "A protein complex that binds to a recombinase and incrseases its activity." [PMID:32414915]
+synonym: "DNA recombinase accessory factor complex" EXACT [PMID:32414915]
+synonym: "DNA recombinase activator complex" EXACT [PMID:32414915]
+is_a: GO:0150005 ! enzyme activator complex
+created_by: krc
+creation_date: 2020-06-18T16:12:52Z
+
+[Term]
+id: GO:0120232
+name: prenyl-FMNH2 biosynthetic process
+namespace: biological_process
+def: "The chemical reactions and pathways resulting in prenyl-FMNH2, an essential cofactor for the decarboxylase enzymes UbiD and Fdc1." [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754]
+synonym: "prenyl-FMNH2 anabolism" EXACT []
+synonym: "prenyl-FMNH2 biosynthesis" EXACT []
+synonym: "prenyl-FMNH2 formation" EXACT []
+synonym: "prenyl-FMNH2 synthesis" EXACT []
+synonym: "prenylated FMNH2 anabolism" EXACT []
+synonym: "prenylated FMNH2 biosynthesis" EXACT []
+synonym: "prenylated FMNH2 biosynthetic process" EXACT []
+synonym: "prenylated FMNH2 formation" EXACT []
+synonym: "prenylated FMNH2 synthesis" EXACT []
+is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
+is_a: GO:0009260 ! ribonucleotide biosynthetic process
+is_a: GO:0042727 ! flavin-containing compound biosynthetic process
+created_by: krc
+creation_date: 2020-06-30T19:09:11Z
+
+[Term]
+id: GO:0120233
+name: prenyl-FMNH2 binding
+namespace: molecular_function
+def: "Interacting selectively and non-covalently with prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1." [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754]
+synonym: "prenylated FMNH2 binding" EXACT []
+is_a: GO:0032553 ! ribonucleotide binding
+is_a: GO:0043168 ! anion binding
+created_by: krc
+creation_date: 2020-06-30T19:32:01Z
+
+[Term]
+id: GO:0120234
+name: stereocilium coat
+namespace: cellular_component
+def: "A glycocalyx on the the endolymphatic surface of a cochlear hair cell that coats the external surface of each stereocilium and maintains a small distance between adjacent stereocilia in the bundle." [GOC:krc, ISBN:9781461268918, PMID:31444330, PMID:3583936]
+synonym: "auditory hair cell glycocalyx" BROAD []
+synonym: "stereocilium glycocalyx" EXACT []
+is_a: GO:0110165 ! cellular anatomical entity
+relationship: part_of GO:0032420 ! stereocilium
+created_by: krc
+creation_date: 2020-07-15T00:56:35Z
+
[Term]
id: GO:0140007
name: KICSTOR complex
@@ -454105,7 +451822,6 @@ id: GO:0140009
name: L-aspartate import across plasma membrane
namespace: biological_process
def: "The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000069, PMID:7914198]
-is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0070778 ! L-aspartate transmembrane transport
is_a: GO:0089718 ! amino acid import across plasma membrane
created_by: pg
@@ -454795,7 +452511,7 @@ creation_date: 2017-09-14T10:32:59Z
id: GO:0140097
name: catalytic activity, acting on DNA
namespace: molecular_function
-def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring\,GOC\:pdt]
+def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt]
is_a: GO:0003824 ! catalytic activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14225 xsd:anyURI
created_by: pg
@@ -454805,7 +452521,7 @@ creation_date: 2017-09-14T12:03:51Z
id: GO:0140098
name: catalytic activity, acting on RNA
namespace: molecular_function
-def: "Catalytic activity that acts to modify RNA." [GOC:molecular_function_refactoring\,GOC\:pdt]
+def: "Catalytic activity that acts to modify RNA." [GOC:molecular_function_refactoring, GOC:pdt]
is_a: GO:0003824 ! catalytic activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14225 xsd:anyURI
created_by: pg
@@ -454848,7 +452564,7 @@ namespace: molecular_function
def: "Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:molecular_function_refactoring, GOC:pdt]
subset: gocheck_do_not_annotate
is_a: GO:0003674 ! molecular_function
-relationship: has_part GO:0051536 ! iron-sulfur cluster binding
+relationship: has_part GO:0036094 ! small molecule binding
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14221 xsd:anyURI
created_by: pg
creation_date: 2017-09-19T13:10:18Z
@@ -454891,7 +452607,7 @@ def: "A molecular function that controls the rate, timing and/or magnitude of tr
subset: gocheck_do_not_annotate
subset: goslim_flybase_ribbon
subset: goslim_plant
-is_a: GO:0003674 ! molecular_function
+is_a: GO:0098772 ! molecular function regulator
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/13588 xsd:anyURI
created_by: pg
creation_date: 2017-10-18T07:05:44Z
@@ -455043,6 +452759,7 @@ name: iron-sulfur cluster carrier activity
namespace: molecular_function
def: "Binding to an iron-sulfur cluster and delivering it to an acceptor molecule." [PMID:22966982, PMID:29051382]
is_a: GO:0140104 ! molecular carrier activity
+relationship: has_part GO:0051536 ! iron-sulfur cluster binding
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14539 xsd:anyURI
created_by: pg
creation_date: 2017-11-10T08:55:38Z
@@ -456360,9 +454077,11 @@ name: intramembrane lipid transporter activity
namespace: molecular_function
def: "Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084]
synonym: "flippase activity" RELATED []
+synonym: "translocase activity" BROAD []
is_a: GO:0005319 ! lipid transporter activity
relationship: part_of GO:0034204 ! lipid translocation
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17648 xsd:anyURI
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19477 xsd:anyURI
created_by: pg
creation_date: 2019-03-01T20:14:09Z
@@ -456380,7 +454099,7 @@ creation_date: 2019-03-22T14:25:43Z
id: GO:0140311
name: protein sequestering activity
namespace: molecular_function
-def: "The selective interaction of a protein with a specific protein, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:1493333]
+def: "The selective interaction of a protein with a specific protein, to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:1493333]
is_a: GO:0140313 ! molecular sequestering activity
intersection_of: GO:0140313 ! molecular sequestering activity
intersection_of: has_part GO:0005515 ! protein binding
@@ -456405,7 +454124,7 @@ creation_date: 2019-03-26T17:01:45Z
id: GO:0140313
name: molecular sequestering activity
namespace: molecular_function
-def: "The selective interaction of a protein with a specific molecule, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076]
+def: "The selective interaction of a protein with a specific molecule to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076]
is_a: GO:0003674 ! molecular_function
relationship: has_part GO:0005488 ! binding
created_by: pg
@@ -456415,8 +454134,8 @@ creation_date: 2019-03-28T10:00:25Z
id: GO:0140314
name: calcium ion sequestering activity
namespace: molecular_function
-def: "The selective interaction of a protein with a calcium ion, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076]
-is_a: GO:0140313 ! molecular sequestering activity
+def: "The selective interaction of a protein with a calcium ion to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076]
+is_a: GO:0140487 ! metal ion sequestering activity
intersection_of: GO:0140313 ! molecular sequestering activity
intersection_of: has_part GO:0005509 ! calcium ion binding
relationship: has_part GO:0005509 ! calcium ion binding
@@ -456427,8 +454146,8 @@ creation_date: 2019-03-28T10:07:18Z
id: GO:0140315
name: iron ion sequestering activity
namespace: molecular_function
-def: "The selective interaction of a protein with an iron ion, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:27780864]
-is_a: GO:0140313 ! molecular sequestering activity
+def: "The selective interaction of a protein with an iron ion to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:27780864]
+is_a: GO:0140487 ! metal ion sequestering activity
intersection_of: GO:0140313 ! molecular sequestering activity
intersection_of: has_part GO:0005506 ! iron ion binding
relationship: has_part GO:0005506 ! iron ion binding
@@ -456462,6 +454181,8 @@ def: "Directly binding to a specific protein and delivering it to a specific cel
comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation.
synonym: "protein carrier activity" RELATED []
synonym: "protein transport chaperone" RELATED []
+xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network"
+xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane"
is_a: GO:0005215 ! transporter activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17073 xsd:anyURI
created_by: pg
@@ -456558,7 +454279,7 @@ id: GO:0140327
name: flippase activity
namespace: molecular_function
def: "Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase]
-comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation.
+comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaftlet of a membrane).
synonym: "flippase activity (exoplasmic to cytosolic leaftlet)" EXACT []
is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity
created_by: pg
@@ -456569,7 +454290,7 @@ id: GO:0140328
name: floppase activity
namespace: molecular_function
def: "Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase]
-comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation.
+comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the cytosolic to the exoplasmic leaftlet of a membrane).
synonym: "floppase activity (cytosolic to exoplasmic leaftlet)" EXACT []
is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity
created_by: pg
@@ -456852,6 +454573,12 @@ synonym: "ABC-type uptake permease activity" EXACT []
synonym: "ATP binding cassette transporter" EXACT []
synonym: "ATP-binding cassette (ABC) transporter activity" EXACT []
synonym: "ATP-binding cassette transporter" EXACT []
+xref: Reactome:R-HSA-266070 "LTC4 is exported from the cytosol by ABCC1"
+xref: Reactome:R-HSA-5223313 "ABCD4 may transport Cbl from lysosomal lumen to cytosol"
+xref: Reactome:R-HSA-5362459 "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol"
+xref: Reactome:R-HSA-5387389 "Hh processing variants are translocated to the cytosol in a VCP-dependent manner"
+xref: Reactome:R-HSA-5683325 "Defective ABCD4 does not transport Cbl from lysosomal lumen to cytosol"
+xref: Reactome:R-HSA-9661405 "ABCC1 transports BIL from cytosol to extracellular region (blood)"
xref: TC:3.A.1
xref: Wikipedia:ATP-binding_cassette_transporter
is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity
@@ -457002,7 +454729,6 @@ namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product." [PMID:28763571]
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0006796 ! phosphate-containing compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0035835 ! indole alkaloid biosynthetic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
@@ -457155,7 +454881,7 @@ synonym: "effector-dependent suppression of host immune innate response by symbi
synonym: "effector-mediated suppression of host immune innate response by symbiont" EXACT []
synonym: "effector-mediated suppression of host innate immunity" EXACT []
synonym: "effector-triggered suppression of host immune innate response by symbiont" EXACT []
-is_a: GO:0140404 ! effector-mediated modulation of host innate immune response by symbiont
+is_a: GO:0052170 ! suppression by symbiont of host innate immune response
created_by: pg
creation_date: 2019-12-05T11:34:55Z
@@ -457285,7 +455011,7 @@ id: GO:0140415
name: effector-mediated modulation of host defenses by symbiont
namespace: biological_process
def: "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:30610168]
-is_a: GO:0030682 ! mitigation of host defenses by symbiont
+is_a: GO:0140418 ! effector-mediated modulation of host process by symbiont
created_by: pg
creation_date: 2020-01-20T16:46:41Z
@@ -457317,7 +455043,7 @@ def: "A process mediated by a molecule secreted by a symbiont that results in th
synonym: "effector mediated modulation of host process by symbiont" EXACT []
synonym: "effector triggered modulation of host process by symbiont" EXACT []
synonym: "effector-dependent modulation of host process by symbiont" EXACT []
-is_a: GO:0140415 ! effector-mediated modulation of host defenses by symbiont
+is_a: GO:0030682 ! mitigation of host defenses by symbiont
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18605 xsd:anyURI
created_by: pg
creation_date: 2020-01-29T21:24:42Z
@@ -457391,13 +455117,25 @@ creation_date: 2020-02-11T11:08:57Z
id: GO:0140429
name: positive regulation of mitotic sister chromatid biorientation
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed." [PMID:20739936]
+alt_id: GO:0098783
+alt_id: GO:1990598
+def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed." [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536, PMID:20739936, PMID:21306900]
+synonym: "correction of merotelic kinetochore attachment, mitotic" NARROW []
+synonym: "correction of mono-orientation defects" NARROW []
+synonym: "correction of syntelic kinetochore attachment, mitotic" NARROW [GOC:vw]
+synonym: "repair of mitotic merotelic kinetochore attachment defect" NARROW []
+synonym: "repair of mitotic merotelic kinetochore attachment defects" NARROW []
+synonym: "repair of mitotic mono-orientation defect" NARROW []
+synonym: "repair of mitotic mono-orientation defects" NARROW []
+is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling
+is_a: GO:0140273 ! repair of mitotic kinetochore microtubule attachment defect
is_a: GO:1902425 ! positive regulation of attachment of mitotic spindle microtubules to kinetochore
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990758 ! mitotic sister chromatid biorientation
relationship: positively_regulates GO:1990758 ! mitotic sister chromatid biorientation
-created_by: pg
-creation_date: 2020-02-19T05:16:40Z
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18815 xsd:anyURI
+created_by: jl
+creation_date: 2015-01-05T16:54:39Z
[Term]
id: GO:0140430
@@ -457541,7 +455279,9 @@ name: mitochondrion-plasma membrane adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:31582398]
synonym: "mitochondrion plasma membrane adaptor activity" EXACT []
+synonym: "mitochondrion plasma membrane tether activity" EXACT []
synonym: "plasma membrane-mitochondrion adaptor activity" EXACT []
+synonym: "plasma membrane-mitochondrion tether activity" EXACT []
is_a: GO:0043495 ! protein-membrane adaptor activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/pull/19140 xsd:anyURI
created_by: pg
@@ -457551,7 +455291,7 @@ creation_date: 2020-03-24T13:11:20Z
id: GO:0140444
name: cytoskeleton-nuclear membrane anchor activity
namespace: molecular_function
-def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the plasma membrane." [PMID:16237665]
+def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane." [PMID:16237665]
synonym: "cytoskeletal protein-nuclear membrane adaptor activity" EXACT []
synonym: "cytoskeletal protein-nuclear membrane anchor activity" EXACT []
synonym: "cytoskeleton nuclear membrane anchor activity" EXACT []
@@ -457616,9 +455356,12 @@ name: centromere-nuclear envelope anchor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location." [PMID:31635174]
synonym: "centromere nuclear envelope anchor activity" EXACT []
+synonym: "centromere nuclear envelope tether activity" EXACT []
synonym: "centromere-inner nuclear envelope anchor activity" EXACT []
+synonym: "centromere-inner nuclear envelope tether activity" EXACT []
synonym: "chromosome, centromeric region-nuclear envelope anchor activity" EXACT []
synonym: "nuclear envelope-centromere anchor activity" EXACT []
+synonym: "nuclear envelope-centromere tether activity" EXACT []
is_a: GO:0043495 ! protein-membrane adaptor activity
relationship: part_of GO:0072766 ! centromere clustering at the mitotic interphase nuclear envelope
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19227 xsd:anyURI
@@ -457687,7 +455430,8 @@ name: meiotic spindle pole body duplication
namespace: biological_process
def: "The release of duplicated meiotic spindle pole bodies (SPBs)." [PMID:31532702]
synonym: "initial spindle pole body separation involved in meiosis I" EXACT []
-is_a: GO:0000073 ! initial mitotic spindle pole body separation
+is_a: GO:0110100 ! spindle pole body separation
+is_a: GO:1903046 ! meiotic cell cycle process
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17971 xsd:anyURI
created_by: pg
creation_date: 2020-04-22T19:07:22Z
@@ -457733,6 +455477,290 @@ property_value: term_tracker_item https://github.com/geneontology/go-ontology/is
created_by: pg
creation_date: 2020-04-30T07:34:38Z
+[Term]
+id: GO:0140461
+name: subtelomeric heterochromatin organization
+namespace: biological_process
+def: "The organization of chromatin into heterochromatin at the subtelomeric region of a chromosome." [PMID:26744419]
+is_a: GO:0032200 ! telomere organization
+is_a: GO:0070828 ! heterochromatin organization
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19396 xsd:anyURI
+created_by: pg
+creation_date: 2020-05-06T07:46:53Z
+
+[Term]
+id: GO:0140462
+name: pericentric heterochromatin organization
+namespace: biological_process
+def: "The organization of chromatin into heterochromatin at the pericentric region of a chromosome." [PMID:26744419]
+is_a: GO:0070828 ! heterochromatin organization
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19396 xsd:anyURI
+created_by: pg
+creation_date: 2020-05-06T07:47:09Z
+
+[Term]
+id: GO:0140463
+name: chromatin adaptor
+namespace: molecular_function
+def: "The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex." [PMID:32277274]
+synonym: "chromatin adaptor activity" EXACT []
+synonym: "chromatin receptor" EXACT []
+synonym: "chromatin recruitment" RELATED []
+synonym: "protein-chromatin adaptor activity" EXACT []
+is_a: GO:0030674 ! protein-macromolecule adaptor activity
+relationship: has_part GO:0003682 ! chromatin binding
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17064 xsd:anyURI
+created_by: pg
+creation_date: 2020-05-08T12:31:39Z
+
+[Term]
+id: GO:0140464
+name: silent mating-type cassette heterochromatin organization
+namespace: biological_process
+def: "The organization of chromatin into heterochromatin at a silent mating-type cassette locus." [PMID:26744419]
+is_a: GO:0070828 ! heterochromatin organization
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19396 xsd:anyURI
+created_by: pg
+creation_date: 2020-05-13T05:13:24Z
+
+[Term]
+id: GO:0140466
+name: iron-sulfur cluster export from the mitochondrion
+namespace: biological_process
+def: "The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane." [PMID:31040179]
+is_a: GO:1902497 ! iron-sulfur cluster transmembrane transport
+is_a: GO:1990542 ! mitochondrial transmembrane transport
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19504 xsd:anyURI
+created_by: pg
+creation_date: 2020-05-22T10:01:36Z
+
+[Term]
+id: GO:0140467
+name: integrated stress response signaling
+namespace: biological_process
+def: "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041]
+synonym: "ISR" RELATED []
+xref: Wikipedia:Integrated_stress_response
+is_a: GO:0033554 ! cellular response to stress
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19153 xsd:anyURI
+created_by: pg
+creation_date: 2020-05-26T08:04:10Z
+
+[Term]
+id: GO:0140468
+name: HRI-mediated signaling
+namespace: biological_process
+def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock." [PMID:27629041]
+synonym: "EIF2AK1-mediated signaling" EXACT []
+is_a: GO:0140467 ! integrated stress response signaling
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19153 xsd:anyURI
+created_by: pg
+creation_date: 2020-05-26T08:46:15Z
+
+[Term]
+id: GO:0140469
+name: GCN2-mediated signaling
+namespace: biological_process
+def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation." [PMID:27629041]
+synonym: "EIF2AK4-mediated signaling" EXACT []
+is_a: GO:0034198 ! cellular response to amino acid starvation
+is_a: GO:0140467 ! integrated stress response signaling
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19153 xsd:anyURI
+created_by: pg
+creation_date: 2020-05-26T08:47:25Z
+
+[Term]
+id: GO:0140471
+name: positive regulation of transepithelial migration of symbiont in host
+namespace: biological_process
+def: "Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host." [PMID:29113016]
+synonym: "positive regulation of transmigration of symbiont in host" RELATED []
+is_a: GO:0043903 ! regulation of symbiotic process
+is_a: GO:0048518 ! positive regulation of biological process
+intersection_of: GO:0065007 ! biological regulation
+intersection_of: positively_regulates GO:0035756 ! transepithelial migration of symbiont in host
+relationship: positively_regulates GO:0035756 ! transepithelial migration of symbiont in host
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19601 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-11T15:32:38Z
+
+[Term]
+id: GO:0140472
+name: cell cortex of non-growing cell tip
+namespace: cellular_component
+def: "The region directly beneath the plasma membrane at the cell tip at which no growth takes place." [PMID:17895368]
+is_a: GO:0051285 ! cell cortex of cell tip
+intersection_of: GO:0099738 ! cell cortex region
+intersection_of: part_of GO:0035839 ! non-growing cell tip
+relationship: part_of GO:0035839 ! non-growing cell tip
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17249 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-18T13:33:58Z
+
+[Term]
+id: GO:0140474
+name: mitochondrion-endoplasmic reticulum membrane tether activity
+namespace: molecular_function
+def: "The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:19556461, PMID:27875684]
+synonym: "endoplasmic reticulum-mitochondrion membrane adaptor activity" EXACT []
+synonym: "endoplasmic reticulum-mitochondrion membrane tether activity" EXACT []
+synonym: "ER-mitochondrion membrane adaptor activity" EXACT []
+synonym: "ER-mitochondrion membrane tether activity" EXACT []
+synonym: "mitochondrion-endoplasmic reticulum membrane adaptor activity" EXACT []
+synonym: "mitochondrion-ER membrane adaptor activity" EXACT []
+synonym: "mitochondrion-ER membrane tether activity" EXACT []
+is_a: GO:0043495 ! protein-membrane adaptor activity
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19634 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-22T07:01:14Z
+
+[Term]
+id: GO:0140475
+name: spindle pole body anchor activity
+namespace: molecular_function
+def: "The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way." [PMID:19942852]
+is_a: GO:0008093 ! cytoskeletal anchor activity
+created_by: pg
+creation_date: 2020-06-23T15:54:56Z
+
+[Term]
+id: GO:0140479
+name: ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase
+namespace: biological_process
+def: "A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide." [PMID:22209968, PMID:24828577]
+is_a: GO:0052699 ! ergothioneine biosynthetic process
+created_by: pg
+creation_date: 2020-06-25T09:58:21Z
+
+[Term]
+id: GO:0140480
+name: mitotic spindle pole body insertion into the nuclear envelope
+namespace: biological_process
+def: "A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane." [PMID:19487457, PMID:24529240]
+synonym: "establishment of spindle pole body localisation in nuclear envelope" EXACT []
+synonym: "establishment of spindle pole body localization in nuclear envelope" EXACT []
+synonym: "establishment of spindle pole body localization to nuclear envelope" EXACT []
+is_a: GO:1990608 ! mitotic spindle pole body localization
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14887 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-25T14:45:40Z
+
+[Term]
+id: GO:0140481
+name: ATPase-coupled iron-sulfur cluster transmembrane transporter activity
+namespace: molecular_function
+def: "Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out)." [PMID:31040179]
+synonym: "ATPase-coupled Fe-S cluster transmembrane transporter activity" EXACT []
+is_a: GO:0005215 ! transporter activity
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19685 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-25T17:41:01Z
+
+[Term]
+id: GO:0140482
+name: iron sensor activity
+namespace: molecular_function
+def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of iron." [PMID:11956219, PMID:25806539]
+is_a: GO:0140299 ! small molecule sensor activity
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19433 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-25T20:58:02Z
+
+[Term]
+id: GO:0140483
+name: outer kinetochore adaptor activity
+namespace: molecular_function
+def: "The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way." [PMID:22521786]
+is_a: GO:0030674 ! protein-macromolecule adaptor activity
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19701 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-29T08:53:10Z
+
+[Term]
+id: GO:0140486
+name: zinc ion sequestering activity
+namespace: molecular_function
+def: "The selective interaction of a protein with a zinc ion to prevent it from interacting with sensitive components of a biological system." [PMID:12050156]
+is_a: GO:0140487 ! metal ion sequestering activity
+intersection_of: GO:0140313 ! molecular sequestering activity
+intersection_of: has_part GO:0008270 ! zinc ion binding
+relationship: has_part GO:0008270 ! zinc ion binding
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19700 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-29T09:21:42Z
+
+[Term]
+id: GO:0140487
+name: metal ion sequestering activity
+namespace: molecular_function
+def: "The selective interaction of a protein with a metal ion to prevent it from interacting with sensitive components of a biological system." [PMID:12050156]
+is_a: GO:0140313 ! molecular sequestering activity
+intersection_of: GO:0140313 ! molecular sequestering activity
+intersection_of: has_part GO:0046872 ! metal ion binding
+relationship: has_part GO:0046872 ! metal ion binding
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19700 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-29T09:23:47Z
+
+[Term]
+id: GO:0140488
+name: heme receptor activity
+namespace: molecular_function
+def: "Binding specifically to heme to deliver it to a transport vesicle." [PMID:28193844, PMID:32185489]
+is_a: GO:0038024 ! cargo receptor activity
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19699 xsd:anyURI
+created_by: pg
+creation_date: 2020-06-29T14:16:16Z
+
+[Term]
+id: GO:0140489
+name: molecular template activity
+namespace: molecular_function
+def: "The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence." [GOC:pg]
+is_a: GO:0003674 ! molecular_function
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19709 xsd:anyURI
+created_by: pg
+creation_date: 2020-07-01T08:42:18Z
+
+[Term]
+id: GO:0140490
+name: microtubule nucleation template activity
+namespace: molecular_function
+def: "The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly." [PMID:20631709, PMID:21993292]
+is_a: GO:0140489 ! molecular template activity
+created_by: pg
+creation_date: 2020-07-01T08:47:54Z
+
+[Term]
+id: GO:0140493
+name: very long-chain fatty acid beta-oxidation
+namespace: biological_process
+def: "A fatty acid beta-oxidation pathway acting on fatty acid which has a chain length greater than C22 in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:ha, PMID:17028011, PMID:32169171]
+is_a: GO:0033540 ! fatty acid beta-oxidation using acyl-CoA oxidase
+is_a: GO:0042760 ! very long-chain fatty acid catabolic process
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19735 xsd:anyURI
+created_by: pg
+creation_date: 2020-07-10T08:39:22Z
+
+[Term]
+id: GO:0140494
+name: migrasome
+namespace: cellular_component
+def: "A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration." [PMID:25342562, PMID:31371827]
+is_a: GO:0043226 ! organelle
+created_by: pg
+creation_date: 2020-07-10T15:09:40Z
+
+[Term]
+id: GO:0140495
+name: migracytosis
+namespace: biological_process
+def: "A cell migration-dependent mechanism for releasing cellular contents." [PMID:25342562]
+is_a: GO:0016477 ! cell migration
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19760 xsd:anyURI
+created_by: pg
+creation_date: 2020-07-10T15:13:46Z
+
[Term]
id: GO:0150001
name: primary dendrite
@@ -458788,47 +456816,6 @@ relationship: regulates GO:0070633 ! transepithelial transport
created_by: bc
creation_date: 2019-09-15T07:16:49Z
-[Term]
-id: GO:0150112
-name: regulation of interleukin-7 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-7 secretion." [GOC:aruk, PMID:25962782]
-is_a: GO:0032676 ! regulation of interleukin-7 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0072605 ! interleukin-7 secretion
-relationship: regulates GO:0072605 ! interleukin-7 secretion
-created_by: bc
-creation_date: 2019-10-27T08:50:42Z
-
-[Term]
-id: GO:0150113
-name: negative regulation of interleukin-7 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-7 secretion." [GOC:aruk, PMID:25962782]
-is_a: GO:0032716 ! negative regulation of interleukin-7 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:0150112 ! regulation of interleukin-7 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0072605 ! interleukin-7 secretion
-relationship: negatively_regulates GO:0072605 ! interleukin-7 secretion
-created_by: bc
-creation_date: 2019-10-27T08:53:35Z
-
-[Term]
-id: GO:0150114
-name: positive regulation of interleukin-7 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-7 secretion." [GOC:aruk]
-is_a: GO:0032756 ! positive regulation of interleukin-7 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:0150112 ! regulation of interleukin-7 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0072605 ! interleukin-7 secretion
-relationship: positively_regulates GO:0072605 ! interleukin-7 secretion
-created_by: bc
-creation_date: 2019-10-27T08:55:49Z
-
[Term]
id: GO:0150115
name: cell-substrate junction organization
@@ -458890,271 +456877,113 @@ relationship: negatively_regulates GO:0150105 ! protein localization to cell-cel
created_by: bc
creation_date: 2019-11-21T13:53:34Z
-[Term]
-id: GO:0150120
-name: regulation of interleukin-18 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-18 secretion." [GOC:aruk, PMID:23710316]
-is_a: GO:0032661 ! regulation of interleukin-18 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0072616 ! interleukin-18 secretion
-relationship: regulates GO:0072616 ! interleukin-18 secretion
-created_by: bc
-creation_date: 2019-11-27T11:37:50Z
-
-[Term]
-id: GO:0150121
-name: negative regulation of interleukin-18 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18 secretion." [GOC:aruk, PMID:23710316]
-is_a: GO:0032701 ! negative regulation of interleukin-18 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:0150120 ! regulation of interleukin-18 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0072616 ! interleukin-18 secretion
-relationship: negatively_regulates GO:0072616 ! interleukin-18 secretion
-created_by: bc
-creation_date: 2019-11-27T11:40:37Z
-
-[Term]
-id: GO:0150122
-name: positive regulation of interleukin-18 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-18 secretion." [GOC:aruk]
-is_a: GO:0032741 ! positive regulation of interleukin-18 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:0150120 ! regulation of interleukin-18 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0072616 ! interleukin-18 secretion
-relationship: positively_regulates GO:0072616 ! interleukin-18 secretion
-created_by: bc
-creation_date: 2019-11-27T11:44:29Z
-
-[Term]
-id: GO:0150123
-name: regulation of interleukin-33 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-33 biosynthetic process." [GOC:aruk, PMID:29778524]
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-is_a: GO:0150127 ! regulation of interleukin-33 production
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0150126 ! interleukin-33 biosynthetic process
-relationship: regulates GO:0150126 ! interleukin-33 biosynthetic process
-created_by: bc
-creation_date: 2019-12-01T16:39:17Z
-
-[Term]
-id: GO:0150124
-name: negative regulation of interleukin-33 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 biosynthetic process." [GOC:aruk, PMID:29778524]
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0150123 ! regulation of interleukin-33 biosynthetic process
-is_a: GO:0150128 ! negative regulation of interleukin-33 production
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0150126 ! interleukin-33 biosynthetic process
-relationship: negatively_regulates GO:0150126 ! interleukin-33 biosynthetic process
-created_by: bc
-creation_date: 2019-12-01T16:39:36Z
-
-[Term]
-id: GO:0150125
-name: positive regulation of interleukin-33 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 biosynthetic process." [GOC:aruk]
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0150123 ! regulation of interleukin-33 biosynthetic process
-is_a: GO:0150129 ! positive regulation of interleukin-33 production
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0150126 ! interleukin-33 biosynthetic process
-relationship: positively_regulates GO:0150126 ! interleukin-33 biosynthetic process
-created_by: bc
-creation_date: 2019-12-01T16:39:45Z
-
-[Term]
-id: GO:0150126
-name: interleukin-33 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-33." [GOC:aruk, PMID:29778524]
-is_a: GO:0042089 ! cytokine biosynthetic process
-is_a: GO:1901566 ! organonitrogen compound biosynthetic process
-relationship: part_of GO:0072639 ! interleukin-33 production
-created_by: bc
-creation_date: 2019-12-01T16:46:17Z
-
[Term]
id: GO:0150127
name: regulation of interleukin-33 production
namespace: biological_process
+alt_id: GO:0150123
+alt_id: GO:0150130
def: "Any process that modulates the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524]
+synonym: "regulation of interleukin-33 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-33 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072639 ! interleukin-33 production
relationship: regulates GO:0072639 ! interleukin-33 production
created_by: bc
-creation_date: 2019-12-01T17:05:01Z
+creation_date: 2019-12-03T05:54:03Z
[Term]
id: GO:0150128
name: negative regulation of interleukin-33 production
namespace: biological_process
+alt_id: GO:0150124
+alt_id: GO:0150131
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524]
+synonym: "negative regulation of interleukin-33 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-33 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0150127 ! regulation of interleukin-33 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072639 ! interleukin-33 production
relationship: negatively_regulates GO:0072639 ! interleukin-33 production
created_by: bc
-creation_date: 2019-12-01T17:08:31Z
+creation_date: 2019-12-03T05:54:24Z
[Term]
id: GO:0150129
name: positive regulation of interleukin-33 production
namespace: biological_process
+alt_id: GO:0150125
+alt_id: GO:0150132
def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 production." [GOC:aruk]
+synonym: "positive regulation of interleukin-33 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-33 secretion" NARROW []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0150127 ! regulation of interleukin-33 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072639 ! interleukin-33 production
relationship: positively_regulates GO:0072639 ! interleukin-33 production
created_by: bc
-creation_date: 2019-12-01T17:10:56Z
-
-[Term]
-id: GO:0150130
-name: regulation of interleukin-33 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-33 secretion." [GOC:aruk, PMID:29778524]
-is_a: GO:0050707 ! regulation of cytokine secretion
-is_a: GO:0150127 ! regulation of interleukin-33 production
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0072640 ! interleukin-33 secretion
-relationship: regulates GO:0072640 ! interleukin-33 secretion
-created_by: bc
-creation_date: 2019-12-03T05:54:03Z
-
-[Term]
-id: GO:0150131
-name: negative regulation of interleukin-33 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 secretion." [GOC:aruk, PMID:29778524]
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:0150128 ! negative regulation of interleukin-33 production
-is_a: GO:0150130 ! regulation of interleukin-33 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0072640 ! interleukin-33 secretion
-relationship: negatively_regulates GO:0072640 ! interleukin-33 secretion
-created_by: bc
-creation_date: 2019-12-03T05:54:24Z
-
-[Term]
-id: GO:0150132
-name: positive regulation of interleukin-33 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 secretion." [GOC:aruk]
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:0150129 ! positive regulation of interleukin-33 production
-is_a: GO:0150130 ! regulation of interleukin-33 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0072640 ! interleukin-33 secretion
-relationship: positively_regulates GO:0072640 ! interleukin-33 secretion
-created_by: bc
creation_date: 2019-12-03T05:54:37Z
-[Term]
-id: GO:0150133
-name: regulation of interleukin-4 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-4 secretion." [GOC:aruk, PMID:29778524]
-is_a: GO:0032673 ! regulation of interleukin-4 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0072602 ! interleukin-4 secretion
-relationship: regulates GO:0072602 ! interleukin-4 secretion
-created_by: bc
-creation_date: 2019-12-03T11:33:28Z
-
-[Term]
-id: GO:0150134
-name: negative regulation of interleukin-4 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4 secretion." [GOC:aruk, PMID:29778524]
-is_a: GO:0032713 ! negative regulation of interleukin-4 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:0150133 ! regulation of interleukin-4 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0072602 ! interleukin-4 secretion
-relationship: negatively_regulates GO:0072602 ! interleukin-4 secretion
-created_by: bc
-creation_date: 2019-12-03T11:33:56Z
-
-[Term]
-id: GO:0150135
-name: positive regulation of interleukin-4 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-4 secretion." [GOC:aruk]
-is_a: GO:0032753 ! positive regulation of interleukin-4 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:0150133 ! regulation of interleukin-4 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0072602 ! interleukin-4 secretion
-relationship: positively_regulates GO:0072602 ! interleukin-4 secretion
-created_by: bc
-creation_date: 2019-12-03T11:35:42Z
-
[Term]
id: GO:0150136
-name: regulation of interleukin-37 biosynthetic process
+name: regulation of interleukin-37 production
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-37 biosynthetic process." [GOC:aruk, PMID:30362558]
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
+def: "Any process that modulates the frequency, rate or extent of interleukin-37 production." [GOC:aruk, PMID:30362558]
+synonym: "regulation of interleukin-37 biosynthetic process" NARROW []
+is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0150137 ! interleukin-37 biosynthetic process
-relationship: regulates GO:0150137 ! interleukin-37 biosynthetic process
+intersection_of: regulates GO:0150137 ! interleukin-37 production
+relationship: regulates GO:0150137 ! interleukin-37 production
created_by: bc
creation_date: 2019-12-08T08:39:07Z
[Term]
id: GO:0150137
-name: interleukin-37 biosynthetic process
+name: interleukin-37 production
namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-37." [GOC:aruk, PMID:30362558]
-is_a: GO:0042089 ! cytokine biosynthetic process
+def: "The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:aruk, PMID:30362558]
+synonym: "interleukin-37 biosynthetic process" NARROW []
+is_a: GO:0001816 ! cytokine production
created_by: bc
creation_date: 2019-12-08T08:43:09Z
[Term]
id: GO:0150138
-name: negative regulation of interleukin-37 biosynthetic process
+name: negative regulation of interleukin-37 production
namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 biosynthetic process." [GOC:aruk, PMID:30362558]
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0150136 ! regulation of interleukin-37 biosynthetic process
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production." [GOC:aruk, PMID:30362558]
+synonym: "negative regulation of interleukin-37 biosynthetic process" NARROW []
+is_a: GO:0001818 ! negative regulation of cytokine production
+is_a: GO:0150136 ! regulation of interleukin-37 production
intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0150137 ! interleukin-37 biosynthetic process
-relationship: negatively_regulates GO:0150137 ! interleukin-37 biosynthetic process
+intersection_of: negatively_regulates GO:0150137 ! interleukin-37 production
+relationship: negatively_regulates GO:0150137 ! interleukin-37 production
created_by: bc
creation_date: 2019-12-08T08:45:29Z
[Term]
id: GO:0150139
-name: positive regulation of interleukin-37 biosynthetic process
+name: positive regulation of interleukin-37 production
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-37 biosynthetic process." [GOC:aruk]
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0150136 ! regulation of interleukin-37 biosynthetic process
+def: "Any process that activates or increases the frequency, rate or extent of interleukin-37 production." [GOC:aruk]
+synonym: "positive regulation of interleukin-37 biosynthetic process" NARROW []
+is_a: GO:0001819 ! positive regulation of cytokine production
+is_a: GO:0150136 ! regulation of interleukin-37 production
intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0150137 ! interleukin-37 biosynthetic process
-relationship: positively_regulates GO:0150137 ! interleukin-37 biosynthetic process
+intersection_of: positively_regulates GO:0150137 ! interleukin-37 production
+relationship: positively_regulates GO:0150137 ! interleukin-37 production
created_by: bc
creation_date: 2019-12-08T08:47:29Z
[Term]
id: GO:0150140
-name: regulation of CD86 biosynthetic process
+name: regulation of CD86 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882]
+synonym: "regulation of CD86 biosynthetic process" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035781 ! CD86 biosynthetic process
@@ -459164,11 +456993,12 @@ creation_date: 2019-12-08T09:31:00Z
[Term]
id: GO:0150141
-name: negative regulation of CD86 biosynthetic process
+name: negative regulation of CD86 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882]
+synonym: "negative regulation of CD86 biosynthetic process" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
-is_a: GO:0150140 ! regulation of CD86 biosynthetic process
+is_a: GO:0150140 ! regulation of CD86 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035781 ! CD86 biosynthetic process
relationship: negatively_regulates GO:0035781 ! CD86 biosynthetic process
@@ -459177,11 +457007,12 @@ creation_date: 2019-12-08T09:33:39Z
[Term]
id: GO:0150142
-name: positive regulation of CD86 biosynthetic process
+name: positive regulation of CD86 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk]
+synonym: "positive regulation of CD86 biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
-is_a: GO:0150140 ! regulation of CD86 biosynthetic process
+is_a: GO:0150140 ! regulation of CD86 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035781 ! CD86 biosynthetic process
relationship: positively_regulates GO:0035781 ! CD86 biosynthetic process
@@ -459190,9 +457021,10 @@ creation_date: 2019-12-08T09:35:35Z
[Term]
id: GO:0150143
-name: regulation of CD80 biosynthetic process
+name: regulation of CD80 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882]
+synonym: "regulation of CD80 biosynthetic process" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035780 ! CD80 biosynthetic process
@@ -459202,11 +457034,12 @@ creation_date: 2019-12-08T10:23:43Z
[Term]
id: GO:0150144
-name: negative regulation of CD80 biosynthetic process
+name: negative regulation of CD80 production
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882]
+synonym: "negative regulation of CD80 biosynthetic process" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
-is_a: GO:0150143 ! regulation of CD80 biosynthetic process
+is_a: GO:0150143 ! regulation of CD80 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035780 ! CD80 biosynthetic process
relationship: negatively_regulates GO:0035780 ! CD80 biosynthetic process
@@ -459215,11 +457048,12 @@ creation_date: 2019-12-08T10:26:42Z
[Term]
id: GO:0150145
-name: positive regulation of CD80 biosynthetic process
+name: positive regulation of CD80 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk]
+synonym: "positive regulation of CD80 biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
-is_a: GO:0150143 ! regulation of CD80 biosynthetic process
+is_a: GO:0150143 ! regulation of CD80 production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035780 ! CD80 biosynthetic process
relationship: positively_regulates GO:0035780 ! CD80 biosynthetic process
@@ -459246,94 +457080,47 @@ is_a: GO:0150146 ! cell junction disassembly
created_by: bc
creation_date: 2019-12-08T11:16:14Z
-[Term]
-id: GO:0150148
-name: regulation of interleukin-25 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-25 secretion." [GOC:aruk, PMID:27901018]
-is_a: GO:0032669 ! regulation of interleukin-25 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0072623 ! interleukin-25 secretion
-relationship: regulates GO:0072623 ! interleukin-25 secretion
-created_by: bc
-creation_date: 2019-12-09T16:51:07Z
-
-[Term]
-id: GO:0150149
-name: negative regulation of interleukin-25 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-25 secretion." [GOC:aruk, PMID:27901018]
-is_a: GO:0032709 ! negative regulation of interleukin-25 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:0150148 ! regulation of interleukin-25 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0072623 ! interleukin-25 secretion
-relationship: negatively_regulates GO:0072623 ! interleukin-25 secretion
-created_by: bc
-creation_date: 2019-12-09T16:51:28Z
-
-[Term]
-id: GO:0150150
-name: positive regulation of interleukin-25 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-25 secretion." [GOC:aruk]
-is_a: GO:0032749 ! positive regulation of interleukin-25 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:0150148 ! regulation of interleukin-25 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0072623 ! interleukin-25 secretion
-relationship: positively_regulates GO:0072623 ! interleukin-25 secretion
-created_by: bc
-creation_date: 2019-12-09T16:51:44Z
-
[Term]
id: GO:0150151
-name: regulation of interleukin-17A biosynthetic process
+name: regulation of interleukin-17A production
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-17A biosynthetic process." [GOC:aruk, PMID:27901018]
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
+def: "Any process that modulates the frequency, rate or extent of interleukin-17A production." [GOC:aruk, PMID:27901018]
+synonym: "regulation of interleukin-17A biosynthetic process" NARROW []
+is_a: GO:0032660 ! regulation of interleukin-17 production
intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0150154 ! interleukin-17A biosynthetic process
-relationship: regulates GO:0150154 ! interleukin-17A biosynthetic process
+intersection_of: regulates GO:0097087 ! interleukin-17A production
+relationship: regulates GO:0097087 ! interleukin-17A production
created_by: bc
creation_date: 2019-12-11T07:44:52Z
[Term]
id: GO:0150152
-name: negative regulation of interleukin-17A biosynthetic process
+name: negative regulation of interleukin-17A production
namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A biosynthetic process." [GOC:aruk, PMID:27901018]
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0150151 ! regulation of interleukin-17A biosynthetic process
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A production." [GOC:aruk, PMID:27901018]
+synonym: "negative regulation of interleukin-17A biosynthetic process" NARROW []
+is_a: GO:0032700 ! negative regulation of interleukin-17 production
+is_a: GO:0150151 ! regulation of interleukin-17A production
intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0150154 ! interleukin-17A biosynthetic process
-relationship: negatively_regulates GO:0150154 ! interleukin-17A biosynthetic process
+intersection_of: negatively_regulates GO:0097087 ! interleukin-17A production
+relationship: negatively_regulates GO:0097087 ! interleukin-17A production
created_by: bc
creation_date: 2019-12-11T07:45:24Z
[Term]
id: GO:0150153
-name: positive regulation of interleukin-17A biosynthetic process
+name: positive regulation of interleukin-17A production
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-17A biosynthetic process." [GOC:aruk]
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0150151 ! regulation of interleukin-17A biosynthetic process
+def: "Any process that activates or increases the frequency, rate or extent of interleukin-17A production." [GOC:aruk]
+synonym: "positive regulation of interleukin-17A biosynthetic process" NARROW []
+is_a: GO:0032740 ! positive regulation of interleukin-17 production
+is_a: GO:0150151 ! regulation of interleukin-17A production
intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0150154 ! interleukin-17A biosynthetic process
-relationship: positively_regulates GO:0150154 ! interleukin-17A biosynthetic process
+intersection_of: positively_regulates GO:0097087 ! interleukin-17A production
+relationship: positively_regulates GO:0097087 ! interleukin-17A production
created_by: bc
creation_date: 2019-12-11T07:45:44Z
-[Term]
-id: GO:0150154
-name: interleukin-17A biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-17A." [GOC:aruk, PMID:27901018]
-is_a: GO:0042089 ! cytokine biosynthetic process
-created_by: bc
-creation_date: 2019-12-11T07:55:52Z
-
[Term]
id: GO:0150155
name: interleukin-34 production
@@ -459343,21 +457130,15 @@ is_a: GO:0001816 ! cytokine production
created_by: bc
creation_date: 2020-01-06T16:25:25Z
-[Term]
-id: GO:0150156
-name: interleukin-34 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-34." [GOC:aruk, PMID:26754294]
-is_a: GO:0042089 ! cytokine biosynthetic process
-relationship: part_of GO:0150155 ! interleukin-34 production
-created_by: bc
-creation_date: 2020-01-06T16:26:08Z
-
[Term]
id: GO:0150157
name: regulation of interleukin-34 production
namespace: biological_process
+alt_id: GO:0150156
+alt_id: GO:0150160
def: "Any process that modulates the frequency, rate or extent of interleukin-34 production." [GOC:aruk, PMID:26754294]
+synonym: "interleukin-34 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-34 biosynthetic process" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0150155 ! interleukin-34 production
@@ -459369,7 +457150,9 @@ creation_date: 2020-01-06T16:30:44Z
id: GO:0150158
name: positive regulation of interleukin-34 production
namespace: biological_process
+alt_id: GO:0150161
def: "Any process that activates or increases the frequency, rate or extent of interleukin-34 production." [GOC:aruk]
+synonym: "positive regulation of interleukin-34 biosynthetic process" NARROW []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0150157 ! regulation of interleukin-34 production
intersection_of: GO:0065007 ! biological regulation
@@ -459382,7 +457165,9 @@ creation_date: 2020-01-06T16:31:00Z
id: GO:0150159
name: negative regulation of interleukin-34 production
namespace: biological_process
+alt_id: GO:0150162
def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production." [GOC:aruk, PMID:26754294]
+synonym: "negative regulation of interleukin-34 biosynthetic process" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0150157 ! regulation of interleukin-34 production
intersection_of: GO:0065007 ! biological regulation
@@ -459391,47 +457176,6 @@ relationship: negatively_regulates GO:0150155 ! interleukin-34 production
created_by: bc
creation_date: 2020-01-06T16:31:12Z
-[Term]
-id: GO:0150160
-name: regulation of interleukin-34 biosynthetic process
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-34 biosynthetic process." [GOC:aruk, PMID:26754294]
-is_a: GO:0042035 ! regulation of cytokine biosynthetic process
-is_a: GO:0150157 ! regulation of interleukin-34 production
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0150156 ! interleukin-34 biosynthetic process
-relationship: regulates GO:0150156 ! interleukin-34 biosynthetic process
-created_by: bc
-creation_date: 2020-01-06T16:31:29Z
-
-[Term]
-id: GO:0150161
-name: positive regulation of interleukin-34 biosynthetic process
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-34 biosynthetic process." [GOC:aruk]
-is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
-is_a: GO:0150158 ! positive regulation of interleukin-34 production
-is_a: GO:0150160 ! regulation of interleukin-34 biosynthetic process
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0150156 ! interleukin-34 biosynthetic process
-relationship: positively_regulates GO:0150156 ! interleukin-34 biosynthetic process
-created_by: bc
-creation_date: 2020-01-06T16:32:11Z
-
-[Term]
-id: GO:0150162
-name: negative regulation of interleukin-34 biosynthetic process
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 biosynthetic process." [GOC:aruk, PMID:26754294]
-is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
-is_a: GO:0150159 ! negative regulation of interleukin-34 production
-is_a: GO:0150160 ! regulation of interleukin-34 biosynthetic process
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0150156 ! interleukin-34 biosynthetic process
-relationship: negatively_regulates GO:0150156 ! interleukin-34 biosynthetic process
-created_by: bc
-creation_date: 2020-01-06T16:32:23Z
-
[Term]
id: GO:0150163
name: miRNA-mediated activation of transcription by RNA polymerase II
@@ -459505,47 +457249,6 @@ relationship: negatively_regulates GO:0043973 ! histone H3-K4 acetylation
created_by: bc
creation_date: 2020-01-14T12:34:01Z
-[Term]
-id: GO:0150169
-name: regulation of interleukin-11 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-11 secretion." [GOC:aruk, PMID:29286137]
-is_a: GO:0032654 ! regulation of interleukin-11 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0072609 ! interleukin-11 secretion
-relationship: regulates GO:0072609 ! interleukin-11 secretion
-created_by: bc
-creation_date: 2020-01-19T10:39:24Z
-
-[Term]
-id: GO:0150170
-name: negative regulation of interleukin-11 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-11 secretion." [GOC:aruk, PMID:29286137]
-is_a: GO:0032694 ! negative regulation of interleukin-11 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:0150169 ! regulation of interleukin-11 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0072609 ! interleukin-11 secretion
-relationship: negatively_regulates GO:0072609 ! interleukin-11 secretion
-created_by: bc
-creation_date: 2020-01-19T10:39:45Z
-
-[Term]
-id: GO:0150171
-name: positive regulation of interleukin-11 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-11 secretion." [GOC:aruk]
-is_a: GO:0032734 ! positive regulation of interleukin-11 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:0150169 ! regulation of interleukin-11 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0072609 ! interleukin-11 secretion
-relationship: positively_regulates GO:0072609 ! interleukin-11 secretion
-created_by: bc
-creation_date: 2020-01-19T10:40:06Z
-
[Term]
id: GO:0150172
name: regulation of phosphatidylcholine metabolic process
@@ -459661,91 +457364,53 @@ relationship: negatively_regulates GO:0006658 ! phosphatidylserine metabolic pro
created_by: bc
creation_date: 2020-01-21T14:06:06Z
-[Term]
-id: GO:0150188
-name: interleukin-32 biosynthetic process
-namespace: biological_process
-def: "The chemical reactions and pathways resulting in the formation of interleukin-32." [GOC:aruk, PMID:23729669]
-is_a: GO:0072637 ! interleukin-32 production
-created_by: bc
-creation_date: 2020-02-21T10:26:40Z
-
[Term]
id: GO:0150189
-name: regulation of interleukin-32 biosynthetic process
+name: regulation of interleukin-32 production
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-32 biosynthetic process." [GOC:aruk, PMID:23729669]
+alt_id: GO:0150192
+def: "Any process that modulates the frequency, rate or extent of interleukin-32 production." [GOC:aruk, PMID:23729669]
+synonym: "regulation of interleukin-32 biosynthetic process" NARROW []
+synonym: "regulation of interleukin-32 secretion" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0150188 ! interleukin-32 biosynthetic process
-relationship: regulates GO:0150188 ! interleukin-32 biosynthetic process
+intersection_of: regulates GO:0072637 ! interleukin-32 production
+relationship: regulates GO:0072637 ! interleukin-32 production
created_by: bc
creation_date: 2020-02-21T10:28:36Z
[Term]
id: GO:0150190
-name: negative regulation of interleukin-32 biosynthetic process
+name: negative regulation of interleukin-32 production
namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 biosynthetic process." [GOC:aruk, PMID:23729669]
+alt_id: GO:0150193
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 production." [GOC:aruk, PMID:23729669]
+synonym: "negative regulation of interleukin-32 biosynthetic process" NARROW []
+synonym: "negative regulation of interleukin-32 secretion" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
-is_a: GO:0150189 ! regulation of interleukin-32 biosynthetic process
+is_a: GO:0150189 ! regulation of interleukin-32 production
intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0150188 ! interleukin-32 biosynthetic process
-relationship: negatively_regulates GO:0150188 ! interleukin-32 biosynthetic process
+intersection_of: negatively_regulates GO:0072637 ! interleukin-32 production
+relationship: negatively_regulates GO:0072637 ! interleukin-32 production
created_by: bc
creation_date: 2020-02-21T10:31:53Z
[Term]
id: GO:0150191
-name: positive regulation of interleukin-32 biosynthetic process
+name: positive regulation of interleukin-32 production
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-32 biosynthetic process." [GOC:aruk]
+alt_id: GO:0150194
+def: "Any process that activates or increases the frequency, rate or extent of interleukin-32 production." [GOC:aruk]
+synonym: "positive regulation of interleukin-32 biosynthetic process" NARROW []
+synonym: "positive regulation of interleukin-32 secretion" NARROW []
is_a: GO:0001819 ! positive regulation of cytokine production
-is_a: GO:0150189 ! regulation of interleukin-32 biosynthetic process
+is_a: GO:0150189 ! regulation of interleukin-32 production
intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0150188 ! interleukin-32 biosynthetic process
-relationship: positively_regulates GO:0150188 ! interleukin-32 biosynthetic process
+intersection_of: positively_regulates GO:0072637 ! interleukin-32 production
+relationship: positively_regulates GO:0072637 ! interleukin-32 production
created_by: bc
creation_date: 2020-02-21T10:33:39Z
-[Term]
-id: GO:0150192
-name: regulation of interleukin-32 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-32 secretion." [GOC:aruk, PMID:23729669]
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:0072638 ! interleukin-32 secretion
-relationship: regulates GO:0072638 ! interleukin-32 secretion
-created_by: bc
-creation_date: 2020-02-21T10:34:56Z
-
-[Term]
-id: GO:0150193
-name: negative regulation of interleukin-32 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 secretion." [GOC:aruk, PMID:23729669]
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:0150192 ! regulation of interleukin-32 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:0072638 ! interleukin-32 secretion
-relationship: negatively_regulates GO:0072638 ! interleukin-32 secretion
-created_by: bc
-creation_date: 2020-02-21T10:36:37Z
-
-[Term]
-id: GO:0150194
-name: positive regulation of interleukin-32 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-32 secretion." [GOC:aruk]
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:0150192 ! regulation of interleukin-32 secretion
-intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:0072638 ! interleukin-32 secretion
-relationship: positively_regulates GO:0072638 ! interleukin-32 secretion
-created_by: bc
-creation_date: 2020-02-21T10:40:55Z
-
[Term]
id: GO:0150195
name: transport across blood-cerebrospinal fluid barrier
@@ -460571,66 +458236,6 @@ relationship: positively_regulates GO:0071456 ! cellular response to hypoxia
created_by: yaf
creation_date: 2012-01-17T09:29:19Z
-[Term]
-id: GO:1900040
-name: regulation of interleukin-2 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf]
-synonym: "regulation of IL-2 secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032663 ! regulation of interleukin-2 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0070970 ! interleukin-2 secretion
-relationship: regulates GO:0070970 ! interleukin-2 secretion
-created_by: yaf
-creation_date: 2012-01-17T11:20:57Z
-
-[Term]
-id: GO:1900041
-name: negative regulation of interleukin-2 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf]
-synonym: "down regulation of IL-2 secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
-synonym: "down-regulation of IL-2 secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
-synonym: "downregulation of IL-2 secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
-synonym: "inhibition of IL-2 secretion" EXACT [GOC:TermGenie]
-synonym: "inhibition of interleukin-2 secretion" RELATED [GOC:TermGenie]
-synonym: "negative regulation of IL-2 secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032703 ! negative regulation of interleukin-2 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:1900040 ! regulation of interleukin-2 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0070970 ! interleukin-2 secretion
-relationship: negatively_regulates GO:0070970 ! interleukin-2 secretion
-created_by: yaf
-creation_date: 2012-01-17T11:21:06Z
-
-[Term]
-id: GO:1900042
-name: positive regulation of interleukin-2 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf]
-synonym: "activation of IL-2 secretion" EXACT [GOC:TermGenie]
-synonym: "activation of interleukin-2 secretion" RELATED [GOC:TermGenie]
-synonym: "positive regulation of IL-2 secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of IL-2 secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
-synonym: "up-regulation of IL-2 secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
-synonym: "upregulation of IL-2 secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of interleukin-2 secretion" RELATED [GOC:TermGenie]
-is_a: GO:0032743 ! positive regulation of interleukin-2 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:1900040 ! regulation of interleukin-2 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0070970 ! interleukin-2 secretion
-relationship: positively_regulates GO:0070970 ! interleukin-2 secretion
-created_by: yaf
-creation_date: 2012-01-17T11:21:10Z
-
[Term]
id: GO:1900043
name: obsolete leptin-mediated signaling pathway involved in negative regulation of appetite
@@ -461164,7 +458769,7 @@ def: "Any process that modulates the frequency, rate or extent of ethanol catabo
synonym: "regulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of ethanol degradation" EXACT [GOC:TermGenie]
-is_a: GO:0031329 ! regulation of cellular catabolic process
+is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0006068 ! ethanol catabolic process
@@ -461196,7 +458801,7 @@ synonym: "upregulation of ethanol breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of ethanol catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of ethanol catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of ethanol degradation" EXACT [GOC:TermGenie]
-is_a: GO:0031331 ! positive regulation of cellular catabolic process
+is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900065 ! regulation of ethanol catabolic process
intersection_of: GO:0008150 ! biological_process
@@ -463425,28 +461030,6 @@ relationship: part_of GO:0003140 ! determination of left/right asymmetry in late
created_by: bf
creation_date: 2012-03-08T02:58:39Z
-[Term]
-id: GO:1900165
-name: negative regulation of interleukin-6 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion." [GOC:TermGenie, GOC:yaf]
-synonym: "down regulation of IL-6 secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of interleukin-6 secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of IL-6 secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of interleukin-6 secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of IL-6 secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of interleukin-6 secretion" EXACT [GOC:TermGenie]
-synonym: "inhibition of IL-6 secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of interleukin-6 secretion" NARROW [GOC:TermGenie]
-synonym: "negative regulation of IL-6 secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032715 ! negative regulation of interleukin-6 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0072604 ! interleukin-6 secretion
-relationship: negatively_regulates GO:0072604 ! interleukin-6 secretion
-created_by: yaf
-creation_date: 2012-03-08T03:27:05Z
-
[Term]
id: GO:1900166
name: regulation of glial cell-derived neurotrophic factor secretion
@@ -464910,7 +462493,7 @@ id: GO:1900228
name: regulation of single-species biofilm formation in or on host organism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie]
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
is_a: GO:1900190 ! regulation of single-species biofilm formation
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0044407 ! single-species biofilm formation in or on host organism
@@ -467307,7 +464890,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
-is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -467361,7 +464943,6 @@ id: GO:1900336
name: regulation of methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie]
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0043457 ! regulation of cellular respiration
is_a: GO:1901577 ! regulation of alkane biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -468005,7 +465586,6 @@ synonym: "up-regulation of RNAi" EXACT [GOC:TermGenie]
synonym: "upregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA interference" EXACT [GOC:TermGenie]
synonym: "upregulation of RNAi" EXACT [GOC:TermGenie]
-is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing
is_a: GO:1900368 ! regulation of RNA interference
intersection_of: GO:0008150 ! biological_process
@@ -468243,7 +465823,6 @@ synonym: "regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0036184 ! asperthecin biosynthetic process
@@ -468276,7 +465855,6 @@ synonym: "negative regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of asperthecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900379 ! regulation of asperthecin biosynthetic process
@@ -468311,7 +465889,6 @@ synonym: "upregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie
synonym: "upregulation of asperthecin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of asperthecin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900379 ! regulation of asperthecin biosynthetic process
@@ -470213,7 +467790,6 @@ synonym: "upregulation of isopentenyl diphosphate synthesis, mevalonate pathway"
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
@@ -470417,7 +467993,6 @@ synonym: "negative regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process
is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA
intersection_of: GO:0008150 ! biological_process
@@ -470443,7 +468018,6 @@ synonym: "upregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXAC
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process
is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA
intersection_of: GO:0008150 ! biological_process
@@ -470463,7 +468037,6 @@ is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0044582 ! butyryl-CoA catabolic process to butanol
@@ -470490,7 +468063,6 @@ is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -470518,7 +468090,6 @@ is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -470538,7 +468109,6 @@ is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
relationship: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
@@ -470564,7 +468134,6 @@ is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
@@ -470591,7 +468160,6 @@ is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate
@@ -470655,8 +468223,7 @@ synonym: "regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie]
synonym: "regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
-is_a: GO:0031326 ! regulation of cellular biosynthetic process
-is_a: GO:0051193 ! regulation of cofactor metabolic process
+is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
relationship: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
@@ -470697,9 +468264,8 @@ synonym: "negative regulation of FeMoco biosynthetic process" EXACT [GOC:TermGen
synonym: "negative regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
-is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly
+is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
relationship: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
@@ -470740,9 +468306,8 @@ synonym: "upregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGeni
synonym: "upregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie]
-is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly
+is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
relationship: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly
@@ -470755,7 +468320,6 @@ name: regulation of pentose catabolic process to ethanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
-is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:1902930 ! regulation of alcohol biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -470780,7 +468344,6 @@ synonym: "inhibition of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
synonym: "negative regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
-is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol
is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -470805,7 +468368,6 @@ synonym: "upregulation of pentose catabolic process to ethanol" EXACT [GOC:TermG
synonym: "upregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
-is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol
is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -471279,8 +468841,8 @@ name: fumonisin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumonisin." [GOC:TermGenie]
synonym: "fumonisin metabolism" RELATED []
+is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:0043385 ! mycotoxin metabolic process
created_by: tb
creation_date: 2012-05-11T12:53:29Z
@@ -471292,7 +468854,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of fumonisi
synonym: "fumonisin breakdown" EXACT []
synonym: "fumonisin catabolism" EXACT []
synonym: "fumonisin degradation" RELATED []
-is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900539 ! fumonisin metabolic process
@@ -471308,7 +468869,7 @@ synonym: "fumonisin anabolism" EXACT []
synonym: "fumonisin biosynthesis" EXACT []
synonym: "fumonisin formation" EXACT []
synonym: "fumonisin synthesis" EXACT []
-is_a: GO:0043386 ! mycotoxin biosynthetic process
+is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900539 ! fumonisin metabolic process
created_by: tb
@@ -471496,7 +469057,6 @@ name: asperfuranone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving asperfuranone." [GOC:di, GOC:TermGenie]
synonym: "asperfuranone metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
@@ -471518,7 +469078,6 @@ synonym: "asperfuranone degradation" EXACT [GOC:TermGenie]
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0042182 ! ketone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1900552 ! asperfuranone metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -471806,7 +469365,6 @@ name: emodin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving emodin." [GOC:di, GOC:TermGenie]
synonym: "emodin metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:1901661 ! quinone metabolic process
@@ -471822,7 +469380,6 @@ synonym: "emodin breakdown" EXACT [GOC:TermGenie]
synonym: "emodin catabolism" EXACT [GOC:TermGenie]
synonym: "emodin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900573 ! emodin metabolic process
is_a: GO:1901662 ! quinone catabolic process
@@ -472030,7 +469587,7 @@ def: "The chemical reactions and pathways involving violaceol I." [GOC:di, GOC:T
synonym: "violaceol I metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
-is_a: GO:0043385 ! mycotoxin metabolic process
+is_a: GO:0019748 ! secondary metabolic process
created_by: di
creation_date: 2012-05-15T06:50:48Z
@@ -472043,7 +469600,6 @@ synonym: "violaceol I breakdown" EXACT [GOC:TermGenie]
synonym: "violaceol I catabolism" EXACT [GOC:TermGenie]
synonym: "violaceol I degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
-is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900588 ! violaceol I metabolic process
is_a: GO:1901502 ! ether catabolic process
@@ -472060,7 +469616,7 @@ synonym: "violaceol I biosynthesis" EXACT [GOC:TermGenie]
synonym: "violaceol I formation" EXACT [GOC:TermGenie]
synonym: "violaceol I synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
-is_a: GO:0043386 ! mycotoxin biosynthetic process
+is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900588 ! violaceol I metabolic process
is_a: GO:1901503 ! ether biosynthetic process
created_by: di
@@ -472074,7 +469630,7 @@ def: "The chemical reactions and pathways involving violaceol II." [GOC:di, GOC:
synonym: "violaceol II metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0018904 ! ether metabolic process
-is_a: GO:0043385 ! mycotoxin metabolic process
+is_a: GO:0019748 ! secondary metabolic process
created_by: di
creation_date: 2012-05-15T06:51:21Z
@@ -472087,7 +469643,6 @@ synonym: "violaceol II breakdown" EXACT [GOC:TermGenie]
synonym: "violaceol II catabolism" EXACT [GOC:TermGenie]
synonym: "violaceol II degradation" EXACT [GOC:TermGenie]
is_a: GO:0019614 ! catechol-containing compound catabolic process
-is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900591 ! violaceol II metabolic process
is_a: GO:1901502 ! ether catabolic process
@@ -472104,7 +469659,7 @@ synonym: "violaceol II biosynthesis" EXACT [GOC:TermGenie]
synonym: "violaceol II formation" EXACT [GOC:TermGenie]
synonym: "violaceol II synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
-is_a: GO:0043386 ! mycotoxin biosynthetic process
+is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900591 ! violaceol II metabolic process
is_a: GO:1901503 ! ether biosynthetic process
created_by: di
@@ -472254,7 +469809,6 @@ name: tensidol A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tensidol A." [GOC:di, GOC:TermGenie]
synonym: "tensidol A metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
@@ -472273,7 +469827,6 @@ synonym: "tensidol A breakdown" EXACT [GOC:TermGenie]
synonym: "tensidol A catabolism" EXACT [GOC:TermGenie]
synonym: "tensidol A degradation" EXACT [GOC:TermGenie]
is_a: GO:0042182 ! ketone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900603 ! tensidol A metabolic process
@@ -473651,7 +471204,6 @@ synonym: "regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "regulation of emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1900575 ! emodin biosynthetic process
@@ -473689,7 +471241,6 @@ synonym: "negative regulation of emodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900664 ! regulation of emodin biosynthetic process
@@ -473729,7 +471280,6 @@ synonym: "upregulation of emodin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of emodin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900664 ! regulation of emodin biosynthetic process
@@ -473749,7 +471299,6 @@ synonym: "regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1900602 ! endocrocin biosynthetic process
@@ -473787,7 +471336,6 @@ synonym: "negative regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900667 ! regulation of endocrocin biosynthetic process
@@ -473827,7 +471375,6 @@ synonym: "upregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of endocrocin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900667 ! regulation of endocrocin biosynthetic process
@@ -474862,7 +472409,6 @@ synonym: "regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "regulation of siderophore synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
-is_a: GO:0051193 ! regulation of cofactor metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0019290 ! siderophore biosynthetic process
@@ -474921,7 +472467,6 @@ synonym: "negative regulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of siderophore synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900704 ! regulation of siderophore biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -474981,7 +472526,6 @@ synonym: "upregulation of siderophore formation" EXACT [GOC:TermGenie]
synonym: "upregulation of siderophore synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900704 ! regulation of siderophore biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -476117,8 +473661,6 @@ synonym: "L-Carnitine transport" EXACT [GOC:TermGenie]
synonym: "Levocarnitine transport" RELATED [GOC:TermGenie]
synonym: "Vitamin BT transport" RELATED [GOC:TermGenie]
is_a: GO:0015879 ! carnitine transport
-is_a: GO:0015893 ! drug transport
-is_a: GO:0051180 ! vitamin transport
created_by: jl
creation_date: 2012-05-29T02:01:17Z
@@ -476494,8 +474036,8 @@ def: "The chemical reactions and pathways involving fumitremorgin B." [GOC:di, G
synonym: "fumitremorgin B metabolism" EXACT [GOC:TermGenie]
synonym: "Lanosulin metabolic process" RELATED [GOC:TermGenie]
synonym: "Lanosulin metabolism" RELATED [GOC:TermGenie]
+is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0035834 ! indole alkaloid metabolic process
-is_a: GO:0043385 ! mycotoxin metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: di
creation_date: 2012-06-04T09:25:18Z
@@ -476513,8 +474055,6 @@ synonym: "Lanosulin catabolic process" RELATED [GOC:TermGenie]
synonym: "Lanosulin catabolism" RELATED [GOC:TermGenie]
synonym: "Lanosulin degradation" RELATED [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
-is_a: GO:0043387 ! mycotoxin catabolic process
-is_a: GO:0051410 ! detoxification of nitrogen compound
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900770 ! fumitremorgin B metabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
@@ -476536,7 +474076,7 @@ synonym: "Lanosulin biosynthetic process" RELATED [GOC:TermGenie]
synonym: "Lanosulin formation" RELATED [GOC:TermGenie]
synonym: "Lanosulin synthesis" RELATED [GOC:TermGenie]
is_a: GO:0035835 ! indole alkaloid biosynthetic process
-is_a: GO:0043386 ! mycotoxin biosynthetic process
+is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900770 ! fumitremorgin B metabolic process
is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process
created_by: di
@@ -476873,7 +474413,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving terrequinone A." [GOC:di, GOC:TermGenie]
synonym: "terrequinone A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009820 ! alkaloid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -476891,7 +474430,6 @@ synonym: "terrequinone A breakdown" EXACT [GOC:TermGenie]
synonym: "terrequinone A catabolism" EXACT [GOC:TermGenie]
synonym: "terrequinone A degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900794 ! terrequinone A metabolic process
@@ -476927,7 +474465,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving cordyol C." [GOC:di, GOC:TermGenie]
synonym: "cordyol C metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009712 ! catechol-containing compound metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0019748 ! secondary metabolic process
created_by: di
@@ -476941,9 +474478,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of cordyol
synonym: "cordyol C breakdown" EXACT [GOC:TermGenie]
synonym: "cordyol C catabolism" EXACT [GOC:TermGenie]
synonym: "cordyol C degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900797 ! cordyol C metabolic process
is_a: GO:1901502 ! ether catabolic process
@@ -476960,7 +474495,6 @@ synonym: "cordyol C biosynthesis" EXACT [GOC:TermGenie]
synonym: "cordyol C formation" EXACT [GOC:TermGenie]
synonym: "cordyol C synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1900797 ! cordyol C metabolic process
is_a: GO:1901503 ! ether biosynthetic process
@@ -477195,6 +474729,7 @@ is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
+is_a: GO:1900619 ! acetate ester metabolic process
created_by: di
creation_date: 2012-06-04T10:02:28Z
@@ -477236,6 +474771,7 @@ is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
+is_a: GO:1900620 ! acetate ester biosynthetic process
is_a: GO:1900810 ! helvolic acid metabolic process
created_by: di
creation_date: 2012-06-04T10:02:58Z
@@ -477295,8 +474831,8 @@ def: "The chemical reactions and pathways involving ochratoxin A." [GOC:di, GOC:
synonym: "Ochratoxin A metabolic process" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
+is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
-is_a: GO:0043385 ! mycotoxin metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -477316,10 +474852,8 @@ synonym: "ochratoxin A catabolism" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A degradation" EXACT [GOC:TermGenie]
synonym: "ochratoxin A degradation" EXACT [GOC:TermGenie]
is_a: GO:0042219 ! cellular modified amino acid catabolic process
-is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
-is_a: GO:0051410 ! detoxification of nitrogen compound
is_a: GO:0090487 ! secondary metabolite catabolic process
is_a: GO:1900816 ! ochratoxin A metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -477338,8 +474872,8 @@ synonym: "Ochratoxin A formation" EXACT [GOC:TermGenie]
synonym: "Ochratoxin A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
-is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
+is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1900816 ! ochratoxin A metabolic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
@@ -477943,7 +475477,6 @@ synonym: "regulation of terrequinone A formation" EXACT [GOC:TermGenie]
synonym: "regulation of terrequinone A synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1900796 ! terrequinone A biosynthetic process
@@ -477961,7 +475494,6 @@ synonym: "down-regulation of terrequinone A biosynthetic process" EXACT [GOC:Ter
synonym: "downregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process
@@ -477981,7 +475513,6 @@ synonym: "up-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermG
synonym: "upregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process
@@ -478192,7 +475723,6 @@ namespace: biological_process
def: "The directed movement of a glycolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
-is_a: GO:0015893 ! drug transport
created_by: pr
creation_date: 2012-06-12T04:29:56Z
@@ -478297,7 +475827,6 @@ name: heptadec-1-ene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie]
synonym: "heptadec-1-ene metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0042810 ! pheromone metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process
created_by: tt
creation_date: 2012-06-13T01:49:51Z
@@ -478311,7 +475840,6 @@ synonym: "heptadec-1-ene anabolism" EXACT [GOC:TermGenie]
synonym: "heptadec-1-ene biosynthesis" EXACT [GOC:TermGenie]
synonym: "heptadec-1-ene formation" EXACT [GOC:TermGenie]
synonym: "heptadec-1-ene synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0042811 ! pheromone biosynthetic process
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:1900874 ! heptadec-1-ene metabolic process
created_by: tt
@@ -479359,9 +476887,7 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie]
synonym: "regulation of glycine import" BROAD []
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
-is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:1904062 ! regulation of cation transmembrane transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1903804 ! glycine import across plasma membrane
relationship: regulates GO:1903804 ! glycine import across plasma membrane
@@ -479378,12 +476904,10 @@ synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "downregulation of glycine import" EXACT [GOC:TermGenie]
synonym: "inhibition of glycine import" NARROW [GOC:TermGenie]
synonym: "negative regulation of glycine import" BROAD []
-is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900923 ! regulation of glycine import across plasma membrane
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:1903804 ! glycine import across plasma membrane
relationship: negatively_regulates GO:1903804 ! glycine import across plasma membrane
@@ -479400,12 +476924,10 @@ synonym: "positive regulation of glycine import" BROAD []
synonym: "up regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie]
synonym: "upregulation of glycine import" EXACT [GOC:TermGenie]
-is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900923 ! regulation of glycine import across plasma membrane
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:1903804 ! glycine import across plasma membrane
relationship: positively_regulates GO:1903804 ! glycine import across plasma membrane
@@ -479421,7 +476943,6 @@ synonym: "regulation of L-threonine import" BROAD []
synonym: "regulation of L-threonine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:1904062 ! regulation of cation transmembrane transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1903807 ! L-threonine import across plasma membrane
relationship: regulates GO:1903807 ! L-threonine import across plasma membrane
@@ -479446,7 +476967,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:1903807 ! L-threonine import across plasma membrane
relationship: negatively_regulates GO:1903807 ! L-threonine import across plasma membrane
@@ -479472,7 +476992,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:1903807 ! L-threonine import across plasma membrane
relationship: positively_regulates GO:1903807 ! L-threonine import across plasma membrane
@@ -479488,7 +477007,6 @@ synonym: "regulation of L-tyrosine import" BROAD []
synonym: "regulation of L-tyrosine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:1904062 ! regulation of cation transmembrane transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1903808 ! L-tyrosine import across plasma membrane
relationship: regulates GO:1903808 ! L-tyrosine import across plasma membrane
@@ -479514,7 +477032,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:1903808 ! L-tyrosine import across plasma membrane
relationship: negatively_regulates GO:1903808 ! L-tyrosine import across plasma membrane
@@ -479540,7 +477057,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:1903808 ! L-tyrosine import across plasma membrane
relationship: positively_regulates GO:1903808 ! L-tyrosine import across plasma membrane
@@ -481061,7 +478577,6 @@ name: scopolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725]
synonym: "scopolamine metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046448 ! tropane alkaloid metabolic process
is_a: GO:0097176 ! epoxide metabolic process
created_by: yaf
@@ -481076,7 +478591,6 @@ synonym: "scopolamine breakdown" EXACT [GOC:TermGenie]
synonym: "scopolamine catabolism" EXACT [GOC:TermGenie]
synonym: "scopolamine degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1900989 ! scopolamine metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -481829,7 +479343,6 @@ synonym: "regulation of L-glutamine uptake" EXACT [GOC:TermGenie]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:1904062 ! regulation of cation transmembrane transport
is_a: GO:2000485 ! regulation of glutamine transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1903803 ! L-glutamine import across plasma membrane
relationship: regulates GO:1903803 ! L-glutamine import across plasma membrane
@@ -481855,7 +479368,6 @@ is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
is_a: GO:2000486 ! negative regulation of glutamine transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:1903803 ! L-glutamine import across plasma membrane
relationship: negatively_regulates GO:1903803 ! L-glutamine import across plasma membrane
@@ -481881,7 +479393,6 @@ is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
is_a: GO:2000487 ! positive regulation of glutamine transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:1903803 ! L-glutamine import across plasma membrane
relationship: positively_regulates GO:1903803 ! L-glutamine import across plasma membrane
@@ -482103,7 +479614,7 @@ name: atropine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303]
synonym: "atropine metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0017144 ! drug metabolic process
+is_a: GO:0008152 ! metabolic process
created_by: yaf
creation_date: 2012-06-28T04:51:25Z
@@ -482115,7 +479626,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of atropine
synonym: "atropine breakdown" EXACT [GOC:TermGenie]
synonym: "atropine catabolism" EXACT [GOC:TermGenie]
synonym: "atropine degradation" EXACT [GOC:TermGenie]
-is_a: GO:0042737 ! drug catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:1901049 ! atropine metabolic process
created_by: yaf
creation_date: 2012-06-28T04:51:51Z
@@ -482341,7 +479852,6 @@ synonym: "ferulate catabolism" EXACT [GOC:TermGenie]
synonym: "ferulate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0033494 ! ferulate metabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901502 ! ether catabolic process
created_by: tt
@@ -482678,7 +480188,6 @@ synonym: "penicillin G catabolic process" EXACT []
synonym: "penicillin G catabolism" EXACT []
synonym: "penicillin G degradation" EXACT []
is_a: GO:0042317 ! penicillin catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901086 ! benzylpenicillin metabolic process
created_by: yaf
creation_date: 2012-07-05T10:28:59Z
@@ -483079,7 +480588,6 @@ name: tetracenomycin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174]
synonym: "tetracenomycin C metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:1902644 ! tertiary alcohol metabolic process
@@ -483094,7 +480602,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of tetracen
synonym: "tetracenomycin C breakdown" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C catabolism" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046164 ! alcohol catabolic process
@@ -483111,7 +480618,6 @@ synonym: "tetracenomycin C anabolism" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C biosynthesis" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C formation" EXACT [GOC:TermGenie]
synonym: "tetracenomycin C synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901104 ! tetracenomycin C metabolic process
@@ -483125,7 +480631,6 @@ name: granaticin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175]
synonym: "granaticin metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -483141,9 +480646,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of granatic
synonym: "granaticin breakdown" EXACT [GOC:TermGenie]
synonym: "granaticin catabolism" EXACT [GOC:TermGenie]
synonym: "granaticin degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030640 ! polyketide catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901107 ! granaticin metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -483160,7 +480663,6 @@ synonym: "granaticin anabolism" EXACT [GOC:TermGenie]
synonym: "granaticin biosynthesis" EXACT [GOC:TermGenie]
synonym: "granaticin formation" EXACT [GOC:TermGenie]
synonym: "granaticin synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:1901107 ! granaticin metabolic process
@@ -483175,7 +480677,6 @@ name: actinorhodin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173]
synonym: "actinorhodin metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process
@@ -483192,7 +480693,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of actinorh
synonym: "actinorhodin breakdown" EXACT [GOC:TermGenie]
synonym: "actinorhodin catabolism" EXACT [GOC:TermGenie]
synonym: "actinorhodin degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process
@@ -483211,7 +480711,6 @@ synonym: "actinorhodin anabolism" EXACT [GOC:TermGenie]
synonym: "actinorhodin biosynthesis" EXACT [GOC:TermGenie]
synonym: "actinorhodin formation" EXACT [GOC:TermGenie]
synonym: "actinorhodin synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
@@ -483227,7 +480726,6 @@ name: erythromycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240]
synonym: "erythromycin metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0033067 ! macrolide metabolic process
created_by: yaf
@@ -483241,9 +480739,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of erythrom
synonym: "erythromycin breakdown" EXACT [GOC:TermGenie]
synonym: "erythromycin catabolism" EXACT [GOC:TermGenie]
synonym: "erythromycin degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030640 ! polyketide catabolic process
-is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:1901113 ! erythromycin metabolic process
is_a: GO:1901335 ! lactone catabolic process
created_by: yaf
@@ -483310,9 +480806,7 @@ namespace: biological_process
def: "The chemical reactions and pathways involving tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971]
synonym: "tobramycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006807 ! nitrogen compound metabolic process
-is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0016137 ! glycoside metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0019751 ! polyol metabolic process
created_by: yaf
creation_date: 2012-07-11T03:15:19Z
@@ -483325,11 +480819,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of tobramyc
synonym: "tobramycin breakdown" EXACT [GOC:TermGenie]
synonym: "tobramycin catabolism" EXACT [GOC:TermGenie]
synonym: "tobramycin degradation" EXACT [GOC:TermGenie]
-is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0016139 ! glycoside catabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
-is_a: GO:0051410 ! detoxification of nitrogen compound
is_a: GO:1901119 ! tobramycin metabolic process
created_by: yaf
creation_date: 2012-07-11T03:15:43Z
@@ -483343,9 +480834,7 @@ synonym: "tobramycin anabolism" EXACT [GOC:TermGenie]
synonym: "tobramycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "tobramycin formation" EXACT [GOC:TermGenie]
synonym: "tobramycin synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0016138 ! glycoside biosynthetic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901119 ! tobramycin metabolic process
created_by: yaf
@@ -483358,7 +480847,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179]
synonym: "bacitracin A metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006518 ! peptide metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
created_by: yaf
creation_date: 2012-07-11T03:15:56Z
@@ -483370,7 +480858,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of bacitrac
synonym: "bacitracin A breakdown" EXACT [GOC:TermGenie]
synonym: "bacitracin A catabolism" EXACT [GOC:TermGenie]
synonym: "bacitracin A degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:1901122 ! bacitracin A metabolic process
created_by: yaf
@@ -483385,7 +480872,6 @@ synonym: "bacitracin A anabolism" EXACT [GOC:TermGenie]
synonym: "bacitracin A biosynthesis" EXACT [GOC:TermGenie]
synonym: "bacitracin A formation" EXACT [GOC:TermGenie]
synonym: "bacitracin A synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:1901122 ! bacitracin A metabolic process
created_by: yaf
@@ -483397,7 +480883,6 @@ name: candicidin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101]
synonym: "candicidin metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0071704 ! organic substance metabolic process
created_by: yaf
creation_date: 2012-07-11T03:16:32Z
@@ -483410,8 +480895,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of candicid
synonym: "candicidin breakdown" EXACT [GOC:TermGenie]
synonym: "candicidin catabolism" EXACT [GOC:TermGenie]
synonym: "candicidin degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901125 ! candicidin metabolic process
is_a: GO:1901575 ! organic substance catabolic process
created_by: yaf
@@ -483426,7 +480909,6 @@ synonym: "candicidin anabolism" EXACT [GOC:TermGenie]
synonym: "candicidin biosynthesis" EXACT [GOC:TermGenie]
synonym: "candicidin formation" EXACT [GOC:TermGenie]
synonym: "candicidin synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:1901125 ! candicidin metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
created_by: yaf
@@ -483699,9 +481181,7 @@ name: salicylic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with salicylic acid." [GOC:TermGenie, PMID:22699612]
synonym: "salicylic acid receptor" NARROW [PMID:22699612]
-is_a: GO:0008144 ! drug binding
is_a: GO:0033293 ! monocarboxylic acid binding
-is_a: GO:0042562 ! hormone binding
is_a: GO:0097159 ! organic cyclic compound binding
created_by: dhl
creation_date: 2012-07-16T05:26:38Z
@@ -483717,7 +481197,6 @@ synonym: "vistamycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0016137 ! glycoside metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
created_by: yaf
creation_date: 2012-07-17T04:26:45Z
@@ -483734,8 +481213,6 @@ synonym: "vistamycin breakdown" EXACT [GOC:TermGenie]
synonym: "vistamycin catabolism" EXACT [GOC:TermGenie]
synonym: "vistamycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016139 ! glycoside catabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901150 ! vistamycin metabolic process
created_by: yaf
@@ -483756,7 +481233,6 @@ synonym: "vistamycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "vistamycin formation" EXACT [GOC:TermGenie]
synonym: "vistamycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016138 ! glycoside biosynthetic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:1901150 ! vistamycin metabolic process
created_by: yaf
@@ -483782,7 +481258,6 @@ synonym: "paromomycin breakdown" EXACT [GOC:TermGenie]
synonym: "paromomycin catabolism" EXACT [GOC:TermGenie]
synonym: "paromomycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901153 ! paromomycin metabolic process
created_by: yaf
@@ -484012,7 +481487,6 @@ synonym: "naphthalene catabolism" EXACT [GOC:TermGenie]
synonym: "naphthalene degradation" EXACT [GOC:TermGenie]
is_a: GO:0018931 ! naphthalene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
created_by: yaf
creation_date: 2012-07-19T09:33:50Z
@@ -484155,7 +481629,8 @@ synonym: "down regulation of cellular response to caffeine" EXACT [GOC:TermGenie
synonym: "down-regulation of cellular response to caffeine" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular response to caffeine" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular response to caffeine" NARROW [GOC:TermGenie]
-is_a: GO:2001039 ! negative regulation of cellular response to drug
+is_a: GO:0048523 ! negative regulation of cellular process
+is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0071313 ! cellular response to caffeine
relationship: negatively_regulates GO:0071313 ! cellular response to caffeine
@@ -485552,7 +483027,6 @@ namespace: molecular_function
def: "Enables the transfer of (R)-carnitine from one side of a membrane to the other." [GOC:TermGenie, PMID:16365042, PMID:20357772, PMID:20829798]
xref: RHEA:34959
is_a: GO:0015226 ! carnitine transmembrane transporter activity
-is_a: GO:0090482 ! vitamin transmembrane transporter activity
relationship: part_of GO:1902270 ! (R)-carnitine transmembrane transport
created_by: jl
creation_date: 2012-08-07T14:46:17Z
@@ -486090,7 +483564,6 @@ synonym: "cephalosporin C breakdown" EXACT [GOC:TermGenie]
synonym: "cephalosporin C catabolism" EXACT [GOC:TermGenie]
synonym: "cephalosporin C degradation" EXACT [GOC:TermGenie]
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901266 ! cephalosporin C metabolic process
@@ -486349,7 +483822,7 @@ synonym: "FeMo-co metabolism" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor metabolic process" EXACT [GOC:yaf]
synonym: "iron-molybdenum cofactor metabolism" EXACT [GOC:yaf]
synonym: "iron-sulfur-molybdenum cofactor metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0051186 ! cofactor metabolic process
+is_a: GO:0008152 ! metabolic process
created_by: yaf
creation_date: 2012-08-17T15:39:14Z
@@ -486369,7 +483842,7 @@ synonym: "iron-molybdenum degradation" EXACT [GOC:yaf]
synonym: "iron-sulfur-molybdenum cofactor breakdown" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor catabolism" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor degradation" EXACT [GOC:TermGenie]
-is_a: GO:0051187 ! cofactor catabolic process
+is_a: GO:0009056 ! catabolic process
is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process
created_by: yaf
creation_date: 2012-08-17T15:39:36Z
@@ -486393,7 +483866,7 @@ synonym: "iron-sulfur-molybdenum cofactor anabolism" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor formation" EXACT [GOC:TermGenie]
synonym: "iron-sulfur-molybdenum cofactor synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0051188 ! cofactor biosynthetic process
+is_a: GO:0009058 ! biosynthetic process
is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process
created_by: yaf
creation_date: 2012-08-17T15:39:48Z
@@ -486941,7 +484414,7 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie]
synonym: "regulation of sperm motility" BROAD []
synonym: "regulation of sperm movement" BROAD [GOC:TermGenie]
-is_a: GO:1902019 ! regulation of cilium-dependent cell motility
+is_a: GO:0060295 ! regulation of cilium movement involved in cell motility
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0030317 ! flagellated sperm motility
@@ -486964,6 +484437,7 @@ synonym: "inhibition of sperm motility" NARROW [GOC:TermGenie]
synonym: "inhibition of sperm movement" BROAD [GOC:TermGenie]
synonym: "negative regulation of sperm motility" BROAD []
synonym: "negative regulation of sperm movement" BROAD [GOC:TermGenie]
+is_a: GO:0003354 ! negative regulation of cilium movement
is_a: GO:1901317 ! regulation of flagellated sperm motility
is_a: GO:1902020 ! negative regulation of cilium-dependent cell motility
is_a: GO:2000242 ! negative regulation of reproductive process
@@ -487067,8 +484541,6 @@ name: response to chloramphenicol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: tb
creation_date: 2012-08-30T00:01:07Z
@@ -487078,9 +484550,7 @@ id: GO:1901323
name: response to erythromycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:TermGenie]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
@@ -487093,8 +484563,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097327 ! response to antineoplastic agent
created_by: mah
creation_date: 2012-08-30T10:11:07Z
@@ -487105,7 +484573,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-08-30T10:12:16Z
@@ -487115,8 +484582,6 @@ id: GO:1901326
name: response to tetracycline
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:TermGenie]
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
created_by: mah
@@ -487129,7 +484594,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus." [GOC:TermGenie]
synonym: "response to FK506" EXACT [CHEBI:61057]
synonym: "response to tacrolimus hydrate" EXACT [CHEBI:61057]
-is_a: GO:0042493 ! response to drug
+is_a: GO:0042221 ! response to chemical
created_by: mah
creation_date: 2012-08-30T10:14:40Z
@@ -487138,10 +484603,8 @@ id: GO:1901328
name: response to cytochalasin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:TermGenie]
-is_a: GO:0010046 ! response to mycotoxin
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0061478 ! response to platelet aggregation inhibitor
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-08-30T16:36:35Z
@@ -487376,7 +484839,6 @@ name: response to leptomycin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:TermGenie]
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:0070542 ! response to fatty acid
created_by: mah
creation_date: 2012-09-07T13:20:47Z
@@ -487643,7 +485105,6 @@ id: GO:1901354
name: response to L-canavanine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus." [GOC:TermGenie]
-is_a: GO:0017085 ! response to insecticide
is_a: GO:0043200 ! response to amino acid
created_by: mah
creation_date: 2012-09-13T13:11:17Z
@@ -487656,9 +485117,7 @@ def: "Any process that results in a change in state or activity of a cell or an
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:0097305 ! response to alcohol
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901654 ! response to ketone
created_by: mah
creation_date: 2012-09-13T13:12:26Z
@@ -488916,11 +486375,9 @@ synonym: "regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EX
synonym: "regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie]
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -488961,7 +486418,6 @@ synonym: "negative regulation of tetrapyrrole synthesis from glycine and succiny
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
@@ -489003,7 +486459,6 @@ synonym: "upregulation of tetrapyrrole synthesis from glycine and succinyl-CoA"
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process
is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
@@ -489019,7 +486474,6 @@ name: regulation of response to ethanol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:1901419 ! regulation of response to alcohol
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0045471 ! response to ethanol
relationship: regulates GO:0045471 ! response to ethanol
@@ -489037,7 +486491,6 @@ synonym: "downregulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "inhibition of response to ethanol" NARROW [GOC:TermGenie]
is_a: GO:1901416 ! regulation of response to ethanol
is_a: GO:1901420 ! negative regulation of response to alcohol
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0045471 ! response to ethanol
relationship: negatively_regulates GO:0045471 ! response to ethanol
@@ -489055,7 +486508,6 @@ synonym: "up-regulation of response to ethanol" EXACT [GOC:TermGenie]
synonym: "upregulation of response to ethanol" EXACT [GOC:TermGenie]
is_a: GO:1901416 ! regulation of response to ethanol
is_a: GO:1901421 ! positive regulation of response to alcohol
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0045471 ! response to ethanol
relationship: positively_regulates GO:0045471 ! response to ethanol
@@ -489115,7 +486567,6 @@ namespace: biological_process
alt_id: GO:1990336
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie, PMID:24014527]
synonym: "process resulting in tolerance to butan-1-ol" NARROW []
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0097305 ! response to alcohol
[Term]
@@ -489132,9 +486583,7 @@ id: GO:1901424
name: response to toluene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toluene stimulus." [GOC:mengo_curators, GOC:TermGenie]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
created_by: tt
creation_date: 2012-10-01T18:38:32Z
@@ -489143,10 +486592,7 @@ id: GO:1901425
name: response to formic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formic acid stimulus." [GOC:mengo_curators, GOC:TermGenie]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010033 ! response to organic substance
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: tt
creation_date: 2012-10-01T18:43:05Z
@@ -489166,7 +486612,6 @@ id: GO:1901427
name: response to propan-1-ol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a propan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0097305 ! response to alcohol
created_by: tt
creation_date: 2012-10-01T18:55:48Z
@@ -489697,7 +487142,7 @@ id: GO:1901454
name: regulation of response to toluene
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie]
-is_a: GO:2001023 ! regulation of response to drug
+is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1901424 ! response to toluene
relationship: regulates GO:1901424 ! response to toluene
@@ -489713,8 +487158,8 @@ synonym: "down regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "downregulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "inhibition of response to toluene" NARROW [GOC:TermGenie]
+is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901454 ! regulation of response to toluene
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:1901424 ! response to toluene
relationship: negatively_regulates GO:1901424 ! response to toluene
@@ -489730,8 +487175,8 @@ synonym: "activation of response to toluene" NARROW [GOC:TermGenie]
synonym: "up regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to toluene" EXACT [GOC:TermGenie]
synonym: "upregulation of response to toluene" EXACT [GOC:TermGenie]
+is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901454 ! regulation of response to toluene
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:1901424 ! response to toluene
relationship: positively_regulates GO:1901424 ! response to toluene
@@ -489789,7 +487234,7 @@ id: GO:1901460
name: regulation of response to formic acid
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie]
-is_a: GO:2001023 ! regulation of response to drug
+is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1901425 ! response to formic acid
relationship: regulates GO:1901425 ! response to formic acid
@@ -489805,8 +487250,8 @@ synonym: "down regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "downregulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "inhibition of response to formic acid" NARROW [GOC:TermGenie]
+is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901460 ! regulation of response to formic acid
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:1901425 ! response to formic acid
relationship: negatively_regulates GO:1901425 ! response to formic acid
@@ -489822,8 +487267,8 @@ synonym: "activation of response to formic acid" NARROW [GOC:TermGenie]
synonym: "up regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to formic acid" EXACT [GOC:TermGenie]
synonym: "upregulation of response to formic acid" EXACT [GOC:TermGenie]
+is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901460 ! regulation of response to formic acid
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:1901425 ! response to formic acid
relationship: positively_regulates GO:1901425 ! response to formic acid
@@ -490139,8 +487584,8 @@ namespace: biological_process
def: "The directed movement of benomyl across a membrane." [GOC:TermGenie]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "benomyl membrane transport" EXACT []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015900 ! benomyl transport
+is_a: GO:0055085 ! transmembrane transport
created_by: tb
creation_date: 2012-10-04T23:11:36Z
@@ -490511,7 +487956,6 @@ id: GO:1901499
name: response to hexane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexane stimulus." [GOC:mengo_curators, GOC:TermGenie]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2012-10-16T15:14:49Z
@@ -490944,7 +488388,6 @@ name: response to hypochlorite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hypochlorite stimulus." [GOC:pr, GOC:TermGenie, PMID:22223481]
is_a: GO:0000302 ! response to reactive oxygen species
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
created_by: pr
creation_date: 2012-10-24T07:12:21Z
@@ -491381,10 +488824,8 @@ name: response to paracetamol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paracetamol stimulus." [GOC:TermGenie]
synonym: "response to acetaminophen" EXACT []
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2012-11-02T09:43:23Z
@@ -491395,7 +488836,6 @@ name: response to paclitaxel
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GOC:TermGenie]
is_a: GO:0033993 ! response to lipid
-is_a: GO:0097327 ! response to antineoplastic agent
created_by: hp
creation_date: 2012-11-02T09:46:08Z
@@ -491404,11 +488844,8 @@ id: GO:1901556
name: response to candesartan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a candesartan stimulus." [GOC:TermGenie]
-is_a: GO:0001101 ! response to acid chemical
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2012-11-02T09:46:13Z
@@ -491418,9 +488855,7 @@ id: GO:1901557
name: response to fenofibrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus." [GOC:TermGenie]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
is_a: GO:0045472 ! response to ether
is_a: GO:1901654 ! response to ketone
created_by: hp
@@ -491431,9 +488866,7 @@ id: GO:1901558
name: response to metformin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus." [GOC:TermGenie]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0010243 ! response to organonitrogen compound
-is_a: GO:0042493 ! response to drug
created_by: hp
creation_date: 2012-11-02T09:46:24Z
@@ -491444,9 +488877,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ribavirin stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
-is_a: GO:0061479 ! response to reverse transcriptase inhibitor
-is_a: GO:0097329 ! response to antimetabolite
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2012-11-02T09:46:28Z
@@ -491467,8 +488897,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
-is_a: GO:0060992 ! response to fungicide
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-11-02T15:32:33Z
@@ -491478,7 +488906,6 @@ id: GO:1901562
name: response to paraquat
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:TermGenie]
-is_a: GO:0009635 ! response to herbicide
is_a: GO:0010033 ! response to organic substance
created_by: mah
creation_date: 2012-11-02T15:32:41Z
@@ -491492,7 +488919,6 @@ synonym: "response to CPT" EXACT [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043279 ! response to alkaloid
is_a: GO:0097305 ! response to alcohol
-is_a: GO:0097327 ! response to antineoplastic agent
created_by: mah
creation_date: 2012-11-02T15:32:45Z
@@ -491959,7 +489385,6 @@ id: GO:1901593
name: response to GW 7647
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:TermGenie]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -491994,7 +489419,6 @@ name: response to reversine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:TermGenie]
is_a: GO:0014074 ! response to purine-containing compound
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-11-07T17:17:01Z
@@ -492006,8 +489430,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
-is_a: GO:0060992 ! response to fungicide
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mah
creation_date: 2012-11-07T17:17:06Z
@@ -492050,7 +489472,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving strigolactone." [GOC:TermGenie]
synonym: "strigolactone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006714 ! sesquiterpenoid metabolic process
-is_a: GO:0042445 ! hormone metabolic process
is_a: GO:1901334 ! lactone metabolic process
created_by: tb
creation_date: 2012-11-08T01:20:09Z
@@ -492065,7 +489486,6 @@ synonym: "strigolactone biosynthesis" EXACT [GOC:TermGenie]
synonym: "strigolactone formation" EXACT [GOC:TermGenie]
synonym: "strigolactone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
-is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901600 ! strigolactone metabolic process
created_by: tb
@@ -493026,7 +490446,6 @@ synonym: "quinone cofactor metabolic process" RELATED []
synonym: "quinone cofactor metabolism" RELATED []
synonym: "quinone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0042180 ! cellular ketone metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
created_by: pr
creation_date: 2012-11-20T14:44:39Z
@@ -493043,7 +490462,6 @@ synonym: "quinone cofactor catabolic process" RELATED []
synonym: "quinone cofactor catabolism" RELATED []
synonym: "quinone cofactor degradation" RELATED []
synonym: "quinone degradation" EXACT [GOC:TermGenie]
-is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:1901661 ! quinone metabolic process
created_by: pr
@@ -493064,7 +490482,6 @@ synonym: "quinone cofactor formation" RELATED []
synonym: "quinone cofactor synthesis" RELATED []
synonym: "quinone formation" EXACT [GOC:TermGenie]
synonym: "quinone synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:1901661 ! quinone metabolic process
created_by: pr
@@ -493865,7 +491282,6 @@ synonym: "tyramine anabolism" EXACT [GOC:TermGenie]
synonym: "tyramine biosynthesis" EXACT [GOC:TermGenie]
synonym: "tyramine formation" EXACT [GOC:TermGenie]
synonym: "tyramine synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901162 ! primary amino compound biosynthetic process
created_by: tb
@@ -493976,7 +491392,6 @@ synonym: "L-glutamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "L-glutamine formation" EXACT [GOC:TermGenie]
synonym: "L-glutamine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0006542 ! glutamine biosynthetic process
-is_a: GO:0017144 ! drug metabolic process
created_by: pde
creation_date: 2012-12-13T23:32:52Z
@@ -494038,7 +491453,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving (+)-larreatricin." [GOC:TermGenie, pmid:12960376]
synonym: "(+)-larreatricin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: ms
@@ -494226,7 +491640,6 @@ synonym: "regulation of GABA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie]
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0008150 ! biological_process
@@ -494559,7 +491972,6 @@ def: "The chemical reactions and pathways involving monensin A." [GOC:TermGenie,
synonym: "monensin A metabolism" EXACT [GOC:TermGenie]
synonym: "monensin metabolism" EXACT [GOC:yaf]
is_a: GO:0006066 ! alcohol metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -494577,8 +491989,6 @@ synonym: "monensin A degradation" EXACT [GOC:TermGenie]
synonym: "monensin breakdown" EXACT [GOC:yaf]
synonym: "monensin catabolism" EXACT [GOC:yaf]
synonym: "monensin degradation" EXACT [GOC:yaf]
-is_a: GO:0017001 ! antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
@@ -494600,7 +492010,6 @@ synonym: "monensin anabolism" EXACT [GOC:yaf]
synonym: "monensin biosynthesis" EXACT [GOC:yaf]
synonym: "monensin formation" EXACT [GOC:yaf]
synonym: "monensin synthesis" EXACT [GOC:yaf]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
@@ -494643,8 +492052,6 @@ name: quercetin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724]
synonym: "quercetin metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0016999 ! antibiotic metabolic process
-is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0051552 ! flavone metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
created_by: yaf
@@ -494658,9 +492065,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of querceti
synonym: "quercetin breakdown" EXACT [GOC:TermGenie]
synonym: "quercetin catabolism" EXACT [GOC:TermGenie]
synonym: "quercetin degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
-is_a: GO:0042447 ! hormone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
is_a: GO:1901732 ! quercetin metabolic process
@@ -494676,8 +492080,6 @@ synonym: "quercetin anabolism" EXACT [GOC:TermGenie]
synonym: "quercetin biosynthesis" EXACT [GOC:TermGenie]
synonym: "quercetin formation" EXACT [GOC:TermGenie]
synonym: "quercetin synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
-is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
is_a: GO:1901732 ! quercetin metabolic process
@@ -494801,7 +492203,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf]
synonym: "2-deoxystreptamine metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006807 ! nitrogen compound metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0019751 ! polyol metabolic process
created_by: yaf
creation_date: 2013-01-14T10:01:57Z
@@ -494814,7 +492215,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of 2-deoxys
synonym: "2-deoxystreptamine breakdown" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine catabolism" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0046174 ! polyol catabolic process
is_a: GO:1901742 ! 2-deoxystreptamine metabolic process
created_by: yaf
@@ -494829,7 +492229,6 @@ synonym: "2-deoxystreptamine anabolism" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine biosynthesis" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine formation" EXACT [GOC:TermGenie]
synonym: "2-deoxystreptamine synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process
is_a: GO:1901742 ! 2-deoxystreptamine metabolic process
created_by: yaf
@@ -494889,7 +492288,6 @@ synonym: "leukotriene D4 metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
created_by: yaf
creation_date: 2013-01-14T10:56:12Z
@@ -494902,7 +492300,6 @@ synonym: "leukotriene D4 breakdown" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 catabolism" EXACT [GOC:TermGenie]
synonym: "leukotriene D4 degradation" EXACT [GOC:TermGenie]
is_a: GO:0036100 ! leukotriene catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:1901748 ! leukotriene D4 metabolic process
@@ -494991,7 +492388,6 @@ synonym: "vitamin D3 breakdown" EXACT [GOC:yaf]
synonym: "vitamin D3 catabolism" EXACT [GOC:yaf]
synonym: "vitamin D3 degradation" EXACT [GOC:yaf]
is_a: GO:0042369 ! vitamin D catabolic process
-is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0070640 ! vitamin D3 metabolic process
created_by: yaf
@@ -495015,7 +492411,6 @@ synonym: "vitamin D3 formation" EXACT [GOC:yaf]
synonym: "vitamin D3 synthesis" EXACT [GOC:yaf]
is_a: GO:0042368 ! vitamin D biosynthetic process
is_a: GO:0070640 ! vitamin D3 metabolic process
-is_a: GO:0120178 ! steroid hormone biosynthetic process
is_a: GO:1902653 ! secondary alcohol biosynthetic process
created_by: yaf
creation_date: 2013-01-14T11:11:09Z
@@ -495098,7 +492493,6 @@ name: oxytetracycline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168]
synonym: "oxytetracycline metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
created_by: yaf
creation_date: 2013-01-15T09:52:50Z
@@ -495111,9 +492505,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of oxytetra
synonym: "oxytetracycline breakdown" EXACT [GOC:TermGenie]
synonym: "oxytetracycline catabolism" EXACT [GOC:TermGenie]
synonym: "oxytetracycline degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030640 ! polyketide catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901761 ! oxytetracycline metabolic process
created_by: yaf
creation_date: 2013-01-15T09:52:55Z
@@ -495127,7 +492519,6 @@ synonym: "oxytetracycline anabolism" EXACT [GOC:TermGenie]
synonym: "oxytetracycline biosynthesis" EXACT [GOC:TermGenie]
synonym: "oxytetracycline formation" EXACT [GOC:TermGenie]
synonym: "oxytetracycline synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:1901761 ! oxytetracycline metabolic process
created_by: yaf
@@ -495218,7 +492609,6 @@ synonym: "daunorubicin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0044597 ! daunorubicin metabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901662 ! quinone catabolic process
@@ -495251,7 +492641,6 @@ def: "The chemical reactions and pathways involving lincomycin." [GOC:TermGenie,
synonym: "lincomycin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0016143 ! S-glycoside metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -495267,7 +492656,6 @@ synonym: "lincomycin breakdown" EXACT [GOC:TermGenie]
synonym: "lincomycin catabolism" EXACT [GOC:TermGenie]
synonym: "lincomycin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016145 ! S-glycoside catabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0042219 ! cellular modified amino acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -495285,7 +492673,6 @@ synonym: "lincomycin biosynthesis" EXACT [GOC:TermGenie]
synonym: "lincomycin formation" EXACT [GOC:TermGenie]
synonym: "lincomycin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016144 ! S-glycoside biosynthetic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042398 ! cellular modified amino acid biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
@@ -495300,7 +492687,6 @@ name: mitomycin C metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135]
synonym: "mitomycin C metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
@@ -495316,7 +492702,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of mitomyci
synonym: "mitomycin C breakdown" EXACT [GOC:TermGenie]
synonym: "mitomycin C catabolism" EXACT [GOC:TermGenie]
synonym: "mitomycin C degradation" EXACT [GOC:TermGenie]
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
@@ -495349,7 +492734,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094]
synonym: "pentalenolactone metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006714 ! sesquiterpenoid metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0097176 ! epoxide metabolic process
is_a: GO:1901334 ! lactone metabolic process
@@ -495365,7 +492749,6 @@ synonym: "pentalenolactone breakdown" EXACT [GOC:TermGenie]
synonym: "pentalenolactone catabolism" EXACT [GOC:TermGenie]
synonym: "pentalenolactone degradation" EXACT [GOC:TermGenie]
is_a: GO:0016107 ! sesquiterpenoid catabolic process
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901335 ! lactone catabolic process
is_a: GO:1901502 ! ether catabolic process
@@ -495383,7 +492766,6 @@ synonym: "pentalenolactone biosynthesis" EXACT [GOC:TermGenie]
synonym: "pentalenolactone formation" EXACT [GOC:TermGenie]
synonym: "pentalenolactone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901336 ! lactone biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
@@ -495439,7 +492821,6 @@ name: p-cresol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531]
synonym: "p-cresol metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0042212 ! cresol metabolic process
created_by: yaf
creation_date: 2013-01-16T11:03:59Z
@@ -495452,7 +492833,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of p-cresol
synonym: "p-cresol breakdown" EXACT [GOC:TermGenie]
synonym: "p-cresol catabolism" EXACT [GOC:TermGenie]
synonym: "p-cresol degradation" EXACT [GOC:TermGenie]
-is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0046199 ! cresol catabolic process
is_a: GO:1901784 ! p-cresol metabolic process
created_by: yaf
@@ -495467,8 +492847,6 @@ synonym: "p-cresol anabolism" EXACT [GOC:TermGenie]
synonym: "p-cresol biosynthesis" EXACT [GOC:TermGenie]
synonym: "p-cresol formation" EXACT [GOC:TermGenie]
synonym: "p-cresol synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0009403 ! toxin biosynthetic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901784 ! p-cresol metabolic process
created_by: yaf
@@ -495520,6 +492898,7 @@ name: 3-(2,3-dihydroxyphenyl)propanoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY]
synonym: "3-(2,3-dihydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie]
+is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
created_by: yaf
creation_date: 2013-01-16T11:40:57Z
@@ -495532,6 +492911,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of 3-(2,3-d
synonym: "3-(2,3-dihydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie]
+is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process
created_by: yaf
@@ -495546,6 +492926,7 @@ synonym: "3-(2,3-dihydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie]
synonym: "3-(2,3-dihydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie]
+is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process
created_by: yaf
@@ -495859,7 +493240,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387]
synonym: "astaxanthin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0016122 ! xanthophyll metabolic process
-is_a: GO:0017144 ! drug metabolic process
created_by: yaf
creation_date: 2013-01-22T10:36:59Z
@@ -495872,7 +493252,6 @@ synonym: "astaxanthin breakdown" EXACT [GOC:TermGenie]
synonym: "astaxanthin catabolism" EXACT [GOC:TermGenie]
synonym: "astaxanthin degradation" EXACT [GOC:TermGenie]
is_a: GO:0016124 ! xanthophyll catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:1901813 ! astaxanthin metabolic process
created_by: yaf
creation_date: 2013-01-22T10:37:03Z
@@ -496405,9 +493784,7 @@ namespace: biological_process
def: "The chemical reactions and pathways involving nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830]
synonym: "nicotinate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0072524 ! pyridine-containing compound metabolic process
created_by: yaf
@@ -496423,8 +493800,6 @@ synonym: "nicotinate catabolism" EXACT [GOC:TermGenie]
synonym: "nicotinate degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
-is_a: GO:0042365 ! water-soluble vitamin catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:0072526 ! pyridine-containing compound catabolic process
is_a: GO:1901847 ! nicotinate metabolic process
@@ -496442,7 +493817,6 @@ synonym: "nicotinate formation" EXACT [GOC:TermGenie]
synonym: "nicotinate synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
-is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:0072525 ! pyridine-containing compound biosynthetic process
is_a: GO:1901847 ! nicotinate metabolic process
@@ -496457,7 +493831,6 @@ def: "The chemical reactions and pathways involving 7,8-didemethyl-8-hydroxy-5-d
synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolism" EXACT [GOC:TermGenie]
synonym: "coenzyme F0 metabolism" EXACT [GOC:yaf]
is_a: GO:0046483 ! heterocycle metabolic process
-is_a: GO:0051186 ! cofactor metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
created_by: yaf
@@ -496476,7 +493849,6 @@ synonym: "coenzyme F0 catabolic process" EXACT [GOC:yaf]
synonym: "coenzyme F0 catabolism" EXACT [GOC:yaf]
synonym: "coenzyme F0 degradation" EXACT [GOC:yaf]
is_a: GO:0046700 ! heterocycle catabolic process
-is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process
@@ -496498,7 +493870,6 @@ synonym: "coenzyme F0 biosynthetic process" EXACT [GOC:yaf]
synonym: "coenzyme F0 formation" EXACT [GOC:yaf]
synonym: "coenzyme F0 synthesis" EXACT [GOC:yaf]
is_a: GO:0018130 ! heterocycle biosynthetic process
-is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process
@@ -496781,7 +494152,6 @@ name: ecgonine methyl ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecgonine methyl ester." [GOC:TermGenie, PMID:22665766]
synonym: "ecgonine methyl ester metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046448 ! tropane alkaloid metabolic process
created_by: ms
creation_date: 2013-02-04T11:58:14Z
@@ -496795,7 +494165,6 @@ synonym: "ecgonine methyl ester breakdown" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester catabolism" EXACT [GOC:TermGenie]
synonym: "ecgonine methyl ester degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901867 ! ecgonine methyl ester metabolic process
@@ -497594,7 +494963,6 @@ def: "Any process that results in a change in state or activity of a cell or an
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0014075 ! response to amine
is_a: GO:0045472 ! response to ether
-is_a: GO:0097327 ! response to antineoplastic agent
created_by: hp
creation_date: 2013-02-13T10:14:41Z
@@ -498439,8 +495807,8 @@ namespace: biological_process
def: "The directed movement of S-adenosyl-L-methionine across a membrane." [GOC:TermGenie, PMID:10497160]
synonym: "S-adenosylmethionine transmembrane transport" EXACT []
synonym: "SAM transmembrane transport" EXACT []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015805 ! S-adenosyl-L-methionine transport
+is_a: GO:0055085 ! transmembrane transport
created_by: jl
creation_date: 2013-02-20T14:45:08Z
@@ -498853,11 +496221,8 @@ id: GO:1901986
name: response to ketamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus." [GOC:TermGenie, PMID:11251190]
-is_a: GO:0009410 ! response to xenobiotic stimulus
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0072347 ! response to anesthetic
is_a: GO:1901654 ! response to ketone
created_by: dph
creation_date: 2013-03-15T19:16:35Z
@@ -499504,7 +496869,6 @@ namespace: biological_process
def: "The directed movement of a L-lysine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0006812 ! cation transport
is_a: GO:0015807 ! L-amino acid transport
-is_a: GO:0015893 ! drug transport
created_by: kmv
creation_date: 2013-03-27T16:09:06Z
@@ -499518,7 +496882,6 @@ synonym: "L-arginine import" NARROW []
synonym: "L-arginine uptake" NARROW []
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0015809 ! arginine transport
-is_a: GO:0015893 ! drug transport
created_by: kmv
creation_date: 2013-03-27T16:09:11Z
@@ -499529,7 +496892,6 @@ namespace: biological_process
def: "The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152]
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0015817 ! histidine transport
-is_a: GO:0015893 ! drug transport
created_by: kmv
creation_date: 2013-03-27T16:09:15Z
@@ -500088,7 +497450,6 @@ name: neosartoricin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997]
synonym: "neosartoricin metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
@@ -500108,7 +497469,6 @@ synonym: "neosartoricin degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0042182 ! ketone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:1902048 ! neosartoricin metabolic process
created_by: di
@@ -500254,7 +497614,6 @@ synonym: "(25S)-Delta(7)-dafachronate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
-is_a: GO:0042445 ! hormone metabolic process
created_by: ab
creation_date: 2013-04-13T09:05:27Z
@@ -500267,7 +497626,6 @@ synonym: "(25S)-Delta(4)-dafachronate metabolism" EXACT [GOC:TermGenie]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
-is_a: GO:0042445 ! hormone metabolic process
created_by: ab
creation_date: 2013-04-13T09:22:54Z
@@ -500431,8 +497789,6 @@ id: GO:1902065
name: response to L-glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus." [GOC:TermGenie, PMID:23574009]
-is_a: GO:0007584 ! response to nutrient
-is_a: GO:0042493 ! response to drug
is_a: GO:0043200 ! response to amino acid
created_by: tb
creation_date: 2013-04-16T21:21:14Z
@@ -500446,7 +497802,6 @@ synonym: "regulation of cell wall pectin metabolism" EXACT [GOC:TermGenie]
synonym: "regulation of cellulose and pectin-containing cell wall pectin metabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of pectin metabolism during cell wall biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of plant-type cell wall pectin metabolic process" EXACT [GOC:TermGenie]
-is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:1903338 ! regulation of cell wall organization or biogenesis
@@ -500748,7 +498103,6 @@ name: fumagillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861]
synonym: "fumagillin metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0097176 ! epoxide metabolic process
created_by: di
@@ -500762,8 +498116,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of fumagill
synonym: "fumagillin breakdown" EXACT [GOC:TermGenie]
synonym: "fumagillin catabolism" EXACT [GOC:TermGenie]
synonym: "fumagillin degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
@@ -500781,7 +498133,6 @@ synonym: "fumagillin anabolism" EXACT [GOC:TermGenie]
synonym: "fumagillin biosynthesis" EXACT [GOC:TermGenie]
synonym: "fumagillin formation" EXACT [GOC:TermGenie]
synonym: "fumagillin synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
@@ -500940,6 +498291,7 @@ synonym: "up-regulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "up-regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "upregulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "upregulation of sperm movement" BROAD [GOC:TermGenie]
+is_a: GO:0003353 ! positive regulation of cilium movement
is_a: GO:1901317 ! regulation of flagellated sperm motility
is_a: GO:2000155 ! positive regulation of cilium-dependent cell motility
is_a: GO:2000243 ! positive regulation of reproductive process
@@ -501042,8 +498394,6 @@ synonym: "1alpha,25(OH)2D3 binding" EXACT [CHEBI:17823]
synonym: "1alpha,25-dihydroxycholecalciferol binding" EXACT [CHEBI:17823]
synonym: "1alpha,25-dihydroxyvitamin D3 binding" EXACT [CHEBI:17823]
synonym: "hormonally active vitamin D3 binding" EXACT [GOC:bf]
-is_a: GO:0008144 ! drug binding
-is_a: GO:0042562 ! hormone binding
is_a: GO:1902271 ! D3 vitamins binding
created_by: bf
creation_date: 2013-05-02T09:41:15Z
@@ -501452,7 +498802,6 @@ synonym: "25-hydroxycholecalciferol binding" EXACT [CHEBI:17933]
synonym: "25-hydroxyvitamin D3 binding" EXACT [CHEBI:17933]
synonym: "25OHD3 binding" EXACT [PMID:11799400]
synonym: "calcifediol binding" EXACT [CHEBI:17933]
-is_a: GO:0008144 ! drug binding
is_a: GO:1902271 ! D3 vitamins binding
created_by: bf
creation_date: 2013-05-15T14:55:58Z
@@ -501501,7 +498850,6 @@ name: lithocholic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lithocholic acid." [GOC:bf, GOC:TermGenie, PMID:20371703]
synonym: "LCA binding" EXACT [PMID:20371703]
-is_a: GO:0005496 ! steroid binding
is_a: GO:0032052 ! bile acid binding
created_by: bf
creation_date: 2013-05-15T16:05:12Z
@@ -501512,7 +498860,6 @@ name: chenodeoxycholic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chenodeoxycholic acid." [GOC:bf, GOC:TermGenie, PMID:10334992]
synonym: "CDCA binding" EXACT [CHEBI:16755]
-is_a: GO:0005496 ! steroid binding
is_a: GO:0032052 ! bile acid binding
created_by: bf
creation_date: 2013-05-16T09:17:19Z
@@ -501540,10 +498887,8 @@ namespace: biological_process
def: "The chemical reactions and pathways involving (+)-pinoresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(+)-pinoresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
-is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0042537 ! benzene-containing compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
created_by: ms
@@ -501558,8 +498903,6 @@ synonym: "(+)-pinoresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
-is_a: GO:0042447 ! hormone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901502 ! ether catabolic process
@@ -501578,7 +498921,6 @@ synonym: "(+)-pinoresinol formation" EXACT [GOC:TermGenie]
synonym: "(+)-pinoresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
-is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902124 ! (+)-pinoresinol metabolic process
@@ -501635,7 +498977,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving (+)-lariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(+)-lariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0034308 ! primary alcohol metabolic process
@@ -501651,7 +498992,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of (+)-lari
synonym: "(+)-lariciresinol breakdown" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0034310 ! primary alcohol catabolic process
is_a: GO:0046273 ! lignan catabolic process
@@ -501671,7 +499011,6 @@ synonym: "(+)-lariciresinol biosynthesis" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(+)-lariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0034309 ! primary alcohol biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
@@ -501730,10 +499069,8 @@ namespace: biological_process
def: "The chemical reactions and pathways involving (-)-secoisolariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995]
synonym: "(-)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie]
is_a: GO:0009806 ! lignan metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0034311 ! diol metabolic process
-is_a: GO:0042445 ! hormone metabolic process
created_by: ms
creation_date: 2013-05-21T08:50:19Z
@@ -501747,8 +499084,6 @@ synonym: "(-)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol degradation" EXACT [GOC:TermGenie]
is_a: GO:0019336 ! phenol-containing compound catabolic process
is_a: GO:0034313 ! diol catabolic process
-is_a: GO:0042447 ! hormone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046273 ! lignan catabolic process
is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process
created_by: ms
@@ -501765,7 +499100,6 @@ synonym: "(-)-secoisolariciresinol formation" EXACT [GOC:TermGenie]
synonym: "(-)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009807 ! lignan biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process
-is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process
created_by: ms
@@ -502477,11 +499811,9 @@ namespace: biological_process
def: "The chemical reactions and pathways involving verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274]
synonym: "verruculogen metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006725 ! cellular aromatic compound metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0018904 ! ether metabolic process
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0035834 ! indole alkaloid metabolic process
-is_a: GO:0043385 ! mycotoxin metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
created_by: di
@@ -502498,10 +499830,7 @@ synonym: "verruculogen degradation" EXACT [GOC:TermGenie]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0034313 ! diol catabolic process
-is_a: GO:0042737 ! drug catabolic process
-is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
-is_a: GO:0051410 ! detoxification of nitrogen compound
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901502 ! ether catabolic process
is_a: GO:1902179 ! verruculogen metabolic process
@@ -502519,9 +499848,9 @@ synonym: "verruculogen formation" EXACT [GOC:TermGenie]
synonym: "verruculogen synthesis" EXACT [GOC:TermGenie]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
+is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0035835 ! indole alkaloid biosynthetic process
-is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901503 ! ether biosynthetic process
is_a: GO:1902179 ! verruculogen metabolic process
@@ -503329,7 +500658,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving ketone body." [GOC:pr, GOC:TermGenie]
synonym: "ketone body metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006091 ! generation of precursor metabolites and energy
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:1901568 ! fatty acid derivative metabolic process
created_by: pr
creation_date: 2013-06-13T10:37:54Z
@@ -504228,8 +501556,6 @@ id: GO:1902270
name: (R)-carnitine transmembrane transport
namespace: biological_process
def: "The process in which (R)-carnitine is transported across a membrane." [GOC:TermGenie, PMID:23755272]
-is_a: GO:0006855 ! drug transmembrane transport
-is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:1900749 ! (R)-carnitine transport
is_a: GO:1902603 ! carnitine transmembrane transport
created_by: mcc
@@ -504250,7 +501576,6 @@ name: regulation of (R)-carnitine transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272]
is_a: GO:1904062 ! regulation of cation transmembrane transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1902270 ! (R)-carnitine transmembrane transport
relationship: regulates GO:1902270 ! (R)-carnitine transmembrane transport
@@ -504268,7 +501593,6 @@ synonym: "downregulation of (R)-carnitine transmembrane transport" EXACT [GOC:Te
synonym: "inhibition of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport
relationship: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport
@@ -504286,7 +501610,6 @@ synonym: "up-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:Ter
synonym: "upregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport
relationship: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport
@@ -504920,7 +502243,6 @@ name: hydroquinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hydroquinone." [GOC:bhm, GOC:TermGenie, pmid:15667223]
synonym: "quinol binding" EXACT []
-is_a: GO:0048037 ! cofactor binding
is_a: GO:0097159 ! organic cyclic compound binding
created_by: bhm
creation_date: 2013-07-22T10:10:12Z
@@ -505147,7 +502469,6 @@ synonym: "negative regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0015995 ! chlorophyll biosynthetic process
@@ -505185,7 +502506,6 @@ synonym: "upregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie
synonym: "upregulation of chlorophyll formation" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0015995 ! chlorophyll biosynthetic process
@@ -505543,7 +502863,6 @@ name: response to strigolactone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171]
synonym: "response to strigolactone analog GR24" RELATED [PMID:23893171]
-is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -505556,7 +502875,6 @@ name: cellular response to strigolactone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171]
synonym: "cellular response to strigolactone analog GR24" RELATED [PMID:23893171]
-is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -505571,8 +502889,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
created_by: kmv
creation_date: 2013-08-13T19:29:25Z
@@ -505581,8 +502897,6 @@ id: GO:1902350
name: cellular response to chloroquine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1902349 ! response to chloroquine
@@ -505594,11 +502908,8 @@ id: GO:1902351
name: response to imidacloprid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an imidacloprid stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0017085 ! response to insecticide
-is_a: GO:0042493 ! response to drug
created_by: kmv
creation_date: 2013-08-13T19:33:15Z
@@ -506248,7 +503559,6 @@ name: glycyrrhetinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycyrrhetinate." [GOC:TermGenie, pmid:22128119]
synonym: "glycyrrhetinate metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
@@ -506266,7 +503576,6 @@ synonym: "glycyrrhetinate catabolism" EXACT [GOC:TermGenie]
synonym: "glycyrrhetinate degradation" EXACT [GOC:TermGenie]
is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process
is_a: GO:0042182 ! ketone catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
is_a: GO:1902384 ! glycyrrhetinate metabolic process
@@ -507229,8 +504538,6 @@ id: GO:1902444
name: riboflavin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with riboflavin." [GOC:TermGenie, PMID:12083520]
-is_a: GO:0008144 ! drug binding
-is_a: GO:0019842 ! vitamin binding
is_a: GO:0043168 ! anion binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
@@ -507944,10 +505251,11 @@ creation_date: 2013-11-13T16:22:49Z
[Term]
id: GO:1902497
-name: iron-sulfur cluster transport
+name: iron-sulfur cluster transmembrane transport
namespace: biological_process
-def: "The directed movement of an iron-sulfur cluster into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:19810706]
-is_a: GO:0051181 ! cofactor transport
+def: "A process in which an iron-sulfur cluster is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:19810706]
+synonym: "iron-sulfur cluster transport" BROAD []
+is_a: GO:0034755 ! iron ion transmembrane transport
is_a: GO:1901678 ! iron coordination entity transport
created_by: dph
creation_date: 2013-11-13T16:33:00Z
@@ -508316,9 +505624,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0010243 ! response to organonitrogen compound
-is_a: GO:0097327 ! response to antineoplastic agent
created_by: dw
creation_date: 2013-12-02T09:34:08Z
@@ -508331,7 +505637,6 @@ comment: Note that this term is in the subset of terms that should not be used f
subset: gocheck_do_not_manually_annotate
synonym: "response to docetaxel" RELATED []
is_a: GO:0097305 ! response to alcohol
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901654 ! response to ketone
created_by: dw
creation_date: 2013-12-02T09:44:04Z
@@ -508344,7 +505649,6 @@ def: "Any process that results in a change in state or activity of a cell or an
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
is_a: GO:1901698 ! response to nitrogen compound
@@ -508360,7 +505664,6 @@ def: "Any process that results in a change in state or activity of a cell or an
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1904631 ! response to glucoside
created_by: dw
creation_date: 2013-12-02T09:44:22Z
@@ -508373,9 +505676,7 @@ def: "Any process that results in a change in state or activity of a cell or an
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "response to epirubicin" RELATED []
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:0097305 ! response to alcohol
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901654 ! response to ketone
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1903416 ! response to glycoside
@@ -509663,7 +506964,6 @@ alt_id: GO:0015906
def: "The directed movement of sulfathiazole across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]
synonym: "sulfathiazole transport" BROAD []
synonym: "sulphathiazole transport" BROAD []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0042886 ! amide transport
is_a: GO:0045117 ! azole transmembrane transport
is_a: GO:0072348 ! sulfur compound transport
@@ -509958,7 +507258,6 @@ id: GO:1902617
name: response to fluoride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010035 ! response to inorganic substance
created_by: kmv
creation_date: 2014-01-10T19:41:49Z
@@ -509968,7 +507267,7 @@ id: GO:1902618
name: cellular response to fluoride
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152]
-is_a: GO:0071229 ! cellular response to acid chemical
+is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1902617 ! response to fluoride
created_by: kmv
creation_date: 2014-01-10T19:41:58Z
@@ -510908,7 +508207,7 @@ name: carbon dioxide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with carbon dioxide." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:15491402]
synonym: "CO2 binding" EXACT []
-is_a: GO:0008144 ! drug binding
+is_a: GO:0005488 ! binding
created_by: bhm
creation_date: 2014-02-04T10:38:41Z
@@ -511740,8 +509039,6 @@ name: response to plumbagin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742]
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0061476 ! response to anticoagulant
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901654 ! response to ketone
created_by: mah
creation_date: 2014-02-20T13:49:54Z
@@ -511751,7 +509048,6 @@ id: GO:1902709
name: cellular response to plumbagin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1902708 ! response to plumbagin
@@ -511786,84 +509082,10 @@ def: "A protein complex which is capable of G protein-coupled GABA receptor acti
comment: An example of this is GABR1 in human (UniProt symbol Q9UBS5) in PMID:18790874.
synonym: "G-protein coupled GABA receptor complex" EXACT []
is_a: GO:0038037 ! G protein-coupled receptor dimeric complex
-is_a: GO:0098878 ! neurotransmitter receptor complex
is_a: GO:1902710 ! GABA receptor complex
created_by: bhm
creation_date: 2014-02-21T09:47:03Z
-[Term]
-id: GO:1902713
-name: regulation of interferon-gamma secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405]
-synonym: "regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "regulation of IFNG secretion" EXACT [GOC:TermGenie]
-synonym: "regulation of type II IFN secretion" BROAD [GOC:TermGenie]
-synonym: "regulation of type II interferon secretion" BROAD [GOC:TermGenie]
-is_a: GO:0032649 ! regulation of interferon-gamma production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0072643 ! interferon-gamma secretion
-relationship: regulates GO:0072643 ! interferon-gamma secretion
-created_by: als
-creation_date: 2014-02-21T16:34:19Z
-
-[Term]
-id: GO:1902714
-name: negative regulation of interferon-gamma secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405]
-synonym: "down regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of IFNG secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of IFNG secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of IFNG secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "inhibition of IFN-gamma secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of IFNG secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of interferon-gamma secretion" NARROW [GOC:TermGenie]
-synonym: "negative regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "negative regulation of IFNG secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032689 ! negative regulation of interferon-gamma production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:1902713 ! regulation of interferon-gamma secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0072643 ! interferon-gamma secretion
-relationship: negatively_regulates GO:0072643 ! interferon-gamma secretion
-created_by: als
-creation_date: 2014-02-21T16:34:29Z
-
-[Term]
-id: GO:1902715
-name: positive regulation of interferon-gamma secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405]
-synonym: "activation of IFN-gamma secretion" NARROW [GOC:TermGenie]
-synonym: "activation of IFNG secretion" NARROW [GOC:TermGenie]
-synonym: "activation of interferon-gamma secretion" NARROW [GOC:TermGenie]
-synonym: "positive regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "positive regulation of IFNG secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of IFNG secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of IFNG secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of IFN-gamma secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of IFNG secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of interferon-gamma secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032729 ! positive regulation of interferon-gamma production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:1902713 ! regulation of interferon-gamma secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0072643 ! interferon-gamma secretion
-relationship: positively_regulates GO:0072643 ! interferon-gamma secretion
-created_by: als
-creation_date: 2014-02-21T16:34:38Z
-
[Term]
id: GO:1902716
name: cell cortex of growing cell tip
@@ -512262,77 +509484,6 @@ relationship: regulates GO:0003413 ! chondrocyte differentiation involved in end
created_by: mr
creation_date: 2014-02-26T15:36:15Z
-[Term]
-id: GO:1902739
-name: regulation of interferon-alpha secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501]
-synonym: "regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "regulation of IFNA secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032647 ! regulation of interferon-alpha production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0072642 ! interferon-alpha secretion
-relationship: regulates GO:0072642 ! interferon-alpha secretion
-created_by: mr
-creation_date: 2014-02-26T22:13:20Z
-
-[Term]
-id: GO:1902740
-name: negative regulation of interferon-alpha secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501]
-synonym: "down regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of IFNA secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of IFNA secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of IFNA secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "inhibition of IFN-alpha secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of IFNA secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of interferon-alpha secretion" NARROW [GOC:TermGenie]
-synonym: "negative regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "negative regulation of IFNA secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032687 ! negative regulation of interferon-alpha production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:1902739 ! regulation of interferon-alpha secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0072642 ! interferon-alpha secretion
-relationship: negatively_regulates GO:0072642 ! interferon-alpha secretion
-created_by: mr
-creation_date: 2014-02-26T22:13:30Z
-
-[Term]
-id: GO:1902741
-name: positive regulation of interferon-alpha secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501]
-synonym: "activation of IFN-alpha secretion" NARROW [GOC:TermGenie]
-synonym: "activation of IFNA secretion" NARROW [GOC:TermGenie]
-synonym: "activation of interferon-alpha secretion" NARROW [GOC:TermGenie]
-synonym: "positive regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "positive regulation of IFNA secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of IFNA secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of IFNA secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of IFN-alpha secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of IFNA secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of interferon-alpha secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032727 ! positive regulation of interferon-alpha production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:1902739 ! regulation of interferon-alpha secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0072642 ! interferon-alpha secretion
-relationship: positively_regulates GO:0072642 ! interferon-alpha secretion
-created_by: mr
-creation_date: 2014-02-26T22:13:40Z
-
[Term]
id: GO:1902742
name: apoptotic process involved in development
@@ -513042,7 +510193,6 @@ id: GO:1902788
name: response to isooctane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:1902778 ! response to alkane
created_by: tt
creation_date: 2014-03-21T20:52:51Z
@@ -513052,7 +510202,6 @@ id: GO:1902789
name: cellular response to isooctane
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008]
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1902779 ! cellular response to alkane
is_a: GO:1902788 ! response to isooctane
created_by: tt
@@ -519702,7 +516851,6 @@ id: GO:1903088
name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport
namespace: biological_process
def: "The process in which 5-amino-1-ribofuranosylimidazole-4-carboxamide is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24778186]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0042886 ! amide transport
is_a: GO:0045117 ! azole transmembrane transport
is_a: GO:1901264 ! carbohydrate derivative transport
@@ -519727,7 +516875,6 @@ id: GO:1903090
name: pyridoxal transmembrane transport
namespace: biological_process
def: "The process in which pyridoxal is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0031920 ! pyridoxal transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0098655 ! cation transmembrane transport
@@ -519739,7 +516886,6 @@ id: GO:1903091
name: pyridoxamine transmembrane transport
namespace: biological_process
def: "The process in which pyridoxamine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0031922 ! pyridoxamine transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0098655 ! cation transmembrane transport
@@ -519751,7 +516897,6 @@ id: GO:1903092
name: pyridoxine transmembrane transport
namespace: biological_process
def: "The process in which pyridoxine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0031923 ! pyridoxine transport
is_a: GO:0035461 ! vitamin transmembrane transport
created_by: al
@@ -521020,7 +518165,6 @@ name: response to polycyclic arene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501]
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
created_by: mr
creation_date: 2014-07-09T18:32:59Z
@@ -521029,7 +518173,6 @@ id: GO:1903166
name: cellular response to polycyclic arene
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1903165 ! response to polycyclic arene
created_by: mr
@@ -521440,7 +518583,6 @@ def: "The chemical reactions and pathways involving L-dopa." [GO_REF:0000068, GO
synonym: "L-dopa metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006575 ! cellular modified amino acid metabolic process
is_a: GO:0009072 ! aromatic amino acid family metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
created_by: bf
creation_date: 2014-07-14T15:06:00Z
@@ -521846,7 +518988,6 @@ synonym: "regulation of cell death in response to hydrogen peroxide" EXACT [GOC:
synonym: "regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie]
is_a: GO:1901031 ! regulation of response to reactive oxygen species
is_a: GO:1903201 ! regulation of oxidative stress-induced cell death
-is_a: GO:2001038 ! regulation of cellular response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0036474 ! cell death in response to hydrogen peroxide
relationship: regulates GO:0036474 ! cell death in response to hydrogen peroxide
@@ -521878,7 +519019,6 @@ synonym: "protection against hydrogen peroxide-induced cell death" RELATED [GOC:
is_a: GO:1901032 ! negative regulation of response to reactive oxygen species
is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death
is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death
-is_a: GO:2001039 ! negative regulation of cellular response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0036474 ! cell death in response to hydrogen peroxide
relationship: negatively_regulates GO:0036474 ! cell death in response to hydrogen peroxide
@@ -522291,7 +519431,6 @@ name: quinolinic acid transmembrane transport
namespace: biological_process
def: "The process in which quinolinic acid is transported across a membrane." [GO_REF:0000069, GOC:di, GOC:TermGenie, PMID:23457190]
is_a: GO:0006835 ! dicarboxylic acid transport
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
created_by: di
@@ -524397,11 +521536,9 @@ id: GO:1903329
name: regulation of iron-sulfur cluster assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
-is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
-is_a: GO:0051193 ! regulation of cofactor metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0016226 ! iron-sulfur cluster assembly
relationship: regulates GO:0016226 ! iron-sulfur cluster assembly
@@ -524427,10 +521564,8 @@ synonym: "inhibition of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie
synonym: "inhibition of iron-sulphur cluster assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
-is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0016226 ! iron-sulfur cluster assembly
@@ -524457,11 +521592,9 @@ synonym: "up-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie]
synonym: "upregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie]
-is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0016226 ! iron-sulfur cluster assembly
@@ -524923,7 +522056,6 @@ id: GO:1903350
name: response to dopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]
-is_a: GO:0042493 ! response to drug
is_a: GO:0071869 ! response to catecholamine
created_by: mr
creation_date: 2014-08-19T19:33:26Z
@@ -524933,7 +522065,6 @@ id: GO:1903351
name: cellular response to dopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071870 ! cellular response to catecholamine stimulus
is_a: GO:1903350 ! response to dopamine
created_by: mr
@@ -524944,7 +522075,6 @@ id: GO:1903352
name: L-ornithine transmembrane transport
namespace: biological_process
def: "The directed movement of L-ornithine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015822 ! ornithine transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
@@ -525919,7 +523049,6 @@ id: GO:1903400
name: L-arginine transmembrane transport
namespace: biological_process
def: "The directed movement of L-arginine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:1902023 ! L-arginine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1903826 ! arginine transmembrane transport
@@ -525931,7 +523060,6 @@ id: GO:1903401
name: L-lysine transmembrane transport
namespace: biological_process
def: "The directed movement of L-lysine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902022 ! L-lysine transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
@@ -526234,7 +523362,6 @@ id: GO:1903412
name: response to bile acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -526246,7 +523373,6 @@ id: GO:1903413
name: cellular response to bile acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -526844,8 +523970,8 @@ synonym: "androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie]
synonym: "androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie]
synonym: "androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "androstenedione biosynthetic process" EXACT []
+is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
-is_a: GO:0120178 ! steroid hormone biosynthetic process
created_by: mr
creation_date: 2014-09-19T20:18:19Z
@@ -526964,7 +524090,6 @@ synonym: "regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie
synonym: "regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
-is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process
@@ -527007,7 +524132,7 @@ synonym: "negative regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:
synonym: "negative regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
-is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
+is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -527051,7 +524176,7 @@ synonym: "upregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGen
synonym: "upregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
-is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
+is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -527753,10 +524878,7 @@ id: GO:1903492
name: response to acetylsalicylate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aspirin (acetylsalicylate) stimulus. Aspirin is a non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity." [GO_REF:0000071, GOC:TermGenie, PMID:23392654]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0061476 ! response to anticoagulant
-is_a: GO:0061478 ! response to platelet aggregation inhibitor
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2014-09-25T10:58:23Z
@@ -527768,8 +524890,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clopidogrel stimulus. Clopidogrel is a is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease." [GO_REF:0000071, GOC:TermGenie, PMID:23392654]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0061476 ! response to anticoagulant
-is_a: GO:0061478 ! response to platelet aggregation inhibitor
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: hp
creation_date: 2014-09-25T11:36:42Z
@@ -527779,7 +524899,6 @@ id: GO:1903494
name: response to dehydroepiandrosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
-is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
@@ -527792,7 +524911,6 @@ id: GO:1903495
name: cellular response to dehydroepiandrosterone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228]
-is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
@@ -529351,8 +526469,6 @@ id: GO:1903576
name: response to L-arginine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628]
-is_a: GO:0007584 ! response to nutrient
-is_a: GO:0042493 ! response to drug
is_a: GO:0043200 ! response to amino acid
created_by: mr
creation_date: 2014-10-29T22:18:39Z
@@ -529362,8 +526478,6 @@ id: GO:1903577
name: cellular response to L-arginine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628]
-is_a: GO:0031670 ! cellular response to nutrient
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1903576 ! response to L-arginine
created_by: mr
@@ -529789,7 +526903,6 @@ is_a: GO:0043304 ! regulation of mast cell degranulation
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0051239 ! regulation of multicellular organismal process
-is_a: GO:0051588 ! regulation of neurotransmitter transport
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0002553 ! histamine secretion by mast cell
relationship: regulates GO:0002553 ! histamine secretion by mast cell
@@ -529810,7 +526923,6 @@ is_a: GO:0043305 ! negative regulation of mast cell degranulation
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0051241 ! negative regulation of multicellular organismal process
-is_a: GO:0051589 ! negative regulation of neurotransmitter transport
is_a: GO:1903593 ! regulation of histamine secretion by mast cell
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0002553 ! histamine secretion by mast cell
@@ -529832,7 +526944,6 @@ is_a: GO:0043306 ! positive regulation of mast cell degranulation
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0051240 ! positive regulation of multicellular organismal process
-is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:1903593 ! regulation of histamine secretion by mast cell
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0002553 ! histamine secretion by mast cell
@@ -531040,7 +528151,6 @@ synonym: "negative regulation of chlorophyll breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of chlorophyll degradation" EXACT [GOC:TermGenie]
is_a: GO:0010271 ! regulation of chlorophyll catabolic process
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1901405 ! negative regulation of tetrapyrrole catabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0015996 ! chlorophyll catabolic process
@@ -531073,7 +528183,6 @@ synonym: "upregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of chlorophyll degradation" EXACT [GOC:TermGenie]
is_a: GO:0010271 ! regulation of chlorophyll catabolic process
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1901406 ! positive regulation of tetrapyrrole catabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0015996 ! chlorophyll catabolic process
@@ -532243,7 +529352,6 @@ name: spermine transmembrane transport
namespace: biological_process
def: "The process in which spermine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075]
is_a: GO:0000296 ! spermine transport
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902047 ! polyamine transmembrane transport
created_by: vw
@@ -532315,28 +529423,6 @@ is_a: GO:1904823 ! purine nucleobase transmembrane transport
created_by: vw
creation_date: 2014-12-08T12:18:27Z
-[Term]
-id: GO:1903717
-name: response to ammonia
-namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonia stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267]
-is_a: GO:0009636 ! response to toxic substance
-is_a: GO:0010035 ! response to inorganic substance
-is_a: GO:1901698 ! response to nitrogen compound
-created_by: ha
-creation_date: 2014-12-08T14:55:44Z
-
-[Term]
-id: GO:1903718
-name: cellular response to ammonia
-namespace: biological_process
-def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonia stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267]
-is_a: GO:0097237 ! cellular response to toxic substance
-is_a: GO:1901699 ! cellular response to nitrogen compound
-is_a: GO:1903717 ! response to ammonia
-created_by: ha
-creation_date: 2014-12-08T14:55:54Z
-
[Term]
id: GO:1903719
name: regulation of I-kappaB phosphorylation
@@ -532998,17 +530084,15 @@ creation_date: 2014-12-18T13:05:59Z
[Term]
id: GO:1903759
-name: signal transduction involved in regulation of aerobic respiration
+name: obsolete signal transduction involved in regulation of aerobic respiration
namespace: biological_process
-def: "Any signal transduction that is involved in regulation of aerobic respiration." [GO_REF:0000060, GOC:TermGenie, PMID:19266076]
+def: "OBSOLETE. Any signal transduction that is involved in regulation of aerobic respiration." [GO_REF:0000060, GOC:TermGenie, PMID:19266076]
+comment: The reason for obsoletion is that this represents a GO-CAM model.
synonym: "signaling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie]
synonym: "signaling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie]
synonym: "signalling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie]
synonym: "signalling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie]
-is_a: GO:0007165 ! signal transduction
-intersection_of: GO:0007165 ! signal transduction
-intersection_of: part_of GO:1903715 ! regulation of aerobic respiration
-relationship: part_of GO:1903715 ! regulation of aerobic respiration
+is_obsolete: true
created_by: al
creation_date: 2014-12-18T16:37:50Z
@@ -533599,7 +530683,6 @@ id: GO:1903785
name: L-valine transmembrane transport
namespace: biological_process
def: "The directed movement of L-valine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20944394]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015829 ! valine transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
@@ -533618,7 +530701,6 @@ synonym: "regulation of glutathione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
-is_a: GO:0051193 ! regulation of cofactor metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0006750 ! glutathione biosynthetic process
relationship: regulates GO:0006750 ! glutathione biosynthetic process
@@ -533657,7 +530739,6 @@ synonym: "negative regulation of glutathione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:1903786 ! regulation of glutathione biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0006750 ! glutathione biosynthetic process
@@ -533697,7 +530778,6 @@ synonym: "upregulation of glutathione synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
-is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:1903786 ! regulation of glutathione biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0006750 ! glutathione biosynthetic process
@@ -533736,7 +530816,6 @@ id: GO:1903791
name: uracil transmembrane transport
namespace: biological_process
def: "The process in which uracil is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:8948441]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015857 ! uracil transport
is_a: GO:1904082 ! pyrimidine nucleobase transmembrane transport
created_by: vw
@@ -533781,7 +530860,6 @@ id: GO:1903794
name: cortisol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:18483153]
-is_a: GO:0008144 ! drug binding
is_a: GO:0043178 ! alcohol binding
is_a: GO:1990239 ! steroid hormone binding
created_by: mr
@@ -534053,7 +531131,6 @@ def: "The directed movement of L-glutamine from outside of a cell, across the pl
synonym: "L-glutamine import" BROAD []
synonym: "L-glutamine import into cell" EXACT []
synonym: "L-glutamine uptake" EXACT [GOC:bf]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0006868 ! glutamine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:0098655 ! cation transmembrane transport
@@ -534069,8 +531146,6 @@ alt_id: GO:0036233
def: "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "glycine import" BROAD []
synonym: "glycine import into cell" EXACT []
-is_a: GO:0001504 ! neurotransmitter uptake
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015816 ! glycine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:0098655 ! cation transmembrane transport
@@ -534116,7 +531191,6 @@ def: "The directed movement of L-threonine from outside of a cell, across the pl
synonym: "L-threonine import" BROAD []
synonym: "L-threonine import into cell" EXACT []
synonym: "L-threonine uptake" EXACT [GOC:bf]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015826 ! threonine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:0098655 ! cation transmembrane transport
@@ -534133,7 +531207,6 @@ def: "The directed movement of L-tyrosine from outside of a cell, across the pla
synonym: "L-tyrosine import" BROAD []
synonym: "L-tyrosine import into cell" EXACT []
synonym: "L-tyrosine uptake" EXACT [GOC:bf]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015828 ! tyrosine transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:0098655 ! cation transmembrane transport
@@ -534164,7 +531237,6 @@ alt_id: GO:0090469
def: "The directed movement of L-asparagine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341]
synonym: "asparagine import" BROAD []
synonym: "L-asparagine import into cell" EXACT []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0089718 ! amino acid import across plasma membrane
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1903713 ! asparagine transmembrane transport
@@ -534649,7 +531721,6 @@ id: GO:1903840
name: response to arsenite(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:1903842 ! response to arsenite ion
created_by: mr
creation_date: 2015-01-22T19:49:25Z
@@ -534659,7 +531730,6 @@ id: GO:1903841
name: cellular response to arsenite(3-)
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899]
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:1903840 ! response to arsenite(3-)
is_a: GO:1903843 ! cellular response to arsenite ion
created_by: mr
@@ -535487,6 +532557,7 @@ name: 21-deoxycortisol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 21-deoxycortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0005496 ! steroid binding
+is_a: GO:0043178 ! alcohol binding
created_by: mr
creation_date: 2015-02-06T16:02:54Z
@@ -535515,7 +532586,6 @@ name: 17alpha-hydroxyprogesterone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 17alpha-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282]
is_a: GO:0005496 ! steroid binding
-is_a: GO:0042562 ! hormone binding
is_a: GO:0043178 ! alcohol binding
created_by: mr
creation_date: 2015-02-06T16:03:22Z
@@ -536806,7 +533876,6 @@ name: estradiol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with estradiol." [GO_REF:0000067, GOC:TermGenie, PMID:9048584]
is_a: GO:0005496 ! steroid binding
-is_a: GO:0099130 ! estrogen binding
created_by: sl
creation_date: 2015-02-11T00:11:34Z
@@ -536815,10 +533884,7 @@ id: GO:1903925
name: response to bisphenol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036]
-is_a: GO:0009410 ! response to xenobiotic stimulus
-is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-02-11T00:16:46Z
@@ -536828,10 +533894,7 @@ id: GO:1903926
name: cellular response to bisphenol A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036]
-is_a: GO:0032870 ! cellular response to hormone stimulus
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903925 ! response to bisphenol A
created_by: sl
@@ -536842,8 +533905,6 @@ id: GO:1903927
name: response to cyanide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848]
-is_a: GO:0001101 ! response to acid chemical
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0010033 ! response to organic substance
created_by: sl
creation_date: 2015-02-11T19:04:19Z
@@ -536853,8 +533914,7 @@ id: GO:1903928
name: cellular response to cyanide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848]
-is_a: GO:0071229 ! cellular response to acid chemical
-is_a: GO:0097237 ! cellular response to toxic substance
+is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1903927 ! response to cyanide
created_by: sl
creation_date: 2015-02-11T19:04:28Z
@@ -536969,12 +534029,8 @@ id: GO:1903935
name: response to sodium arsenite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524]
-is_a: GO:0009635 ! response to herbicide
is_a: GO:0010035 ! response to inorganic substance
-is_a: GO:0017085 ! response to insecticide
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:0046685 ! response to arsenic-containing substance
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1902074 ! response to salt
created_by: sl
creation_date: 2015-02-12T20:54:33Z
@@ -536984,10 +534040,7 @@ id: GO:1903936
name: cellular response to sodium arsenite
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071243 ! cellular response to arsenic-containing substance
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1902075 ! cellular response to salt
is_a: GO:1903935 ! response to sodium arsenite
created_by: sl
@@ -536998,7 +534051,6 @@ id: GO:1903937
name: response to acrylamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
@@ -537010,7 +534062,6 @@ name: cellular response to acrylamide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499]
is_a: GO:0071417 ! cellular response to organonitrogen compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1903937 ! response to acrylamide
created_by: sl
@@ -537390,7 +534441,6 @@ id: GO:1903956
name: response to latrunculin B
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin B stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18951025]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
@@ -537404,7 +534454,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin B stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18951025]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1903956 ! response to latrunculin B
created_by: al
@@ -537541,8 +534590,6 @@ name: response to micafungin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959]
is_a: GO:0033993 ! response to lipid
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901652 ! response to peptide
created_by: al
creation_date: 2015-02-27T09:57:38Z
@@ -537552,8 +534599,6 @@ id: GO:1903968
name: cellular response to micafungin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901653 ! cellular response to peptide
is_a: GO:1903967 ! response to micafungin
@@ -537818,10 +534863,8 @@ namespace: molecular_function
def: "Interacting selectively and non-covalently with enterobactin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:21951132]
synonym: "enterochelin binding" EXACT []
synonym: "siderophore binding" BROAD []
+is_a: GO:0005527 ! macrolide binding
is_a: GO:0043168 ! anion binding
-is_a: GO:0048037 ! cofactor binding
-is_a: GO:0097159 ! organic cyclic compound binding
-is_a: GO:1901363 ! heterocyclic compound binding
created_by: mr
creation_date: 2015-03-02T17:21:54Z
@@ -538394,7 +535437,7 @@ id: GO:1904010
name: response to Aroclor 1254
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130]
-is_a: GO:0009636 ! response to toxic substance
+is_a: GO:0042221 ! response to chemical
created_by: sl
creation_date: 2015-03-06T18:35:00Z
@@ -538403,7 +535446,7 @@ id: GO:1904011
name: cellular response to Aroclor 1254
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130]
-is_a: GO:0097237 ! cellular response to toxic substance
+is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904010 ! response to Aroclor 1254
created_by: sl
creation_date: 2015-03-06T18:35:06Z
@@ -539152,8 +536195,6 @@ alt_id: GO:0070283
def: "Interacting selectively and non-covalently with S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]
synonym: "radical SAM enzyme activity" NARROW []
xref: Reactome:R-HSA-947535 "Cyclisation of GTP to precursor Z"
-is_a: GO:0008144 ! drug binding
-is_a: GO:0050662 ! coenzyme binding
is_a: GO:1901681 ! sulfur compound binding
created_by: hal
creation_date: 2015-03-17T10:32:16Z
@@ -539546,7 +536587,6 @@ id: GO:1904067
name: ascr#2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ascr#2." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:22665789]
-is_a: GO:0005550 ! pheromone binding
is_a: GO:0097367 ! carbohydrate derivative binding
created_by: kmv
creation_date: 2015-03-20T01:39:04Z
@@ -540346,8 +537386,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0061478 ! response to platelet aggregation inhibitor
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mr
creation_date: 2015-03-30T22:36:26Z
@@ -540357,7 +537395,6 @@ id: GO:1904102
name: cellular response to acadesine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -541952,33 +538989,35 @@ creation_date: 2015-05-07T17:02:40Z
[Term]
id: GO:1904198
-name: negative regulation of regulation of vascular smooth muscle cell membrane depolarization
+name: negative regulation of regulation of vascular associated smooth muscle cell membrane depolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "down regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "downregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "inhibition of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie]
+synonym: "negative regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT []
is_a: GO:1904180 ! negative regulation of membrane depolarization
intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization
-relationship: negatively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization
+intersection_of: negatively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization
+relationship: negatively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization
created_by: sl
creation_date: 2015-05-07T17:16:44Z
[Term]
id: GO:1904199
-name: positive regulation of regulation of vascular smooth muscle cell membrane depolarization
+name: positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763]
synonym: "activation of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie]
+synonym: "positive regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT []
synonym: "up regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
synonym: "upregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie]
is_a: GO:1904181 ! positive regulation of membrane depolarization
intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization
-relationship: positively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization
+intersection_of: positively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization
+relationship: positively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization
created_by: sl
creation_date: 2015-05-07T17:16:50Z
@@ -542087,66 +539126,6 @@ relationship: positively_regulates GO:0014734 ! skeletal muscle hypertrophy
created_by: sl
creation_date: 2015-05-08T17:38:25Z
-[Term]
-id: GO:1904207
-name: regulation of chemokine (C-C motif) ligand 2 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297]
-synonym: "regulation of CCL2 secretion" EXACT [GOC:TermGenie]
-is_a: GO:0090196 ! regulation of chemokine secretion
-is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
-relationship: regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
-created_by: sl
-creation_date: 2015-05-11T16:47:07Z
-
-[Term]
-id: GO:1904208
-name: negative regulation of chemokine (C-C motif) ligand 2 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297]
-synonym: "down regulation of CCL2 secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of CCL2 secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of CCL2 secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
-synonym: "inhibition of CCL2 secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie]
-synonym: "negative regulation of CCL2 secretion" EXACT [GOC:TermGenie]
-is_a: GO:0090198 ! negative regulation of chemokine secretion
-is_a: GO:1904207 ! regulation of chemokine (C-C motif) ligand 2 secretion
-is_a: GO:2000342 ! negative regulation of chemokine (C-X-C motif) ligand 2 production
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
-relationship: negatively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
-created_by: sl
-creation_date: 2015-05-11T16:47:13Z
-
-[Term]
-id: GO:1904209
-name: positive regulation of chemokine (C-C motif) ligand 2 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297]
-synonym: "activation of CCL2 secretion" NARROW [GOC:TermGenie]
-synonym: "activation of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie]
-synonym: "positive regulation of CCL2 secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of CCL2 secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of CCL2 secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of CCL2 secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie]
-is_a: GO:0090197 ! positive regulation of chemokine secretion
-is_a: GO:1904207 ! regulation of chemokine (C-C motif) ligand 2 secretion
-is_a: GO:2000343 ! positive regulation of chemokine (C-X-C motif) ligand 2 production
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
-relationship: positively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion
-created_by: sl
-creation_date: 2015-05-11T16:47:19Z
-
[Term]
id: GO:1904210
name: VCP-NPL4-UFD1 AAA ATPase complex assembly
@@ -545084,7 +542063,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0036276 ! response to antidepressant
created_by: sl
creation_date: 2015-06-10T17:00:31Z
@@ -545093,7 +542071,6 @@ id: GO:1904308
name: cellular response to desipramine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1904307 ! response to desipramine
@@ -545107,8 +542084,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460]
synonym: "response to 3'-deoxyadenosine" EXACT [GOC:sl]
is_a: GO:0014074 ! response to purine-containing compound
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097329 ! response to antimetabolite
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-06-10T17:10:29Z
@@ -545119,7 +542094,6 @@ name: cellular response to cordycepin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460]
synonym: "cellular response to 3'-deoxyadenosine" EXACT [GOC:sl]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -545191,9 +542165,8 @@ synonym: "response to PAF" EXACT []
synonym: "response to platelet-activating factor" EXACT []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0033993 ! response to lipid
-is_a: GO:0042493 ! response to drug
+is_a: GO:0045472 ! response to ether
is_a: GO:0046683 ! response to organophosphorus
-is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-06-10T18:10:17Z
@@ -545204,10 +542177,9 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918]
synonym: "cellular response to PAF" EXACT []
synonym: "cellular response to platelet-activating factor" EXACT []
-is_a: GO:0035690 ! cellular response to drug
+is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071417 ! cellular response to organonitrogen compound
-is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904316 ! response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
created_by: sl
creation_date: 2015-06-10T18:10:23Z
@@ -545289,8 +542261,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0061478 ! response to platelet aggregation inhibitor
is_a: GO:0097305 ! response to alcohol
is_a: GO:1901654 ! response to ketone
created_by: sl
@@ -545301,8 +542271,6 @@ id: GO:1904322
name: cellular response to forskolin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0097306 ! cellular response to alcohol
@@ -546040,7 +543008,6 @@ name: regulation of calcitonin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900]
is_a: GO:0090276 ! regulation of peptide hormone secretion
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0036161 ! calcitonin secretion
relationship: regulates GO:0036161 ! calcitonin secretion
@@ -546058,7 +543025,6 @@ synonym: "downregulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "inhibition of calcitonin secretion" NARROW [GOC:TermGenie]
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
is_a: GO:1904362 ! regulation of calcitonin secretion
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0036161 ! calcitonin secretion
relationship: negatively_regulates GO:0036161 ! calcitonin secretion
@@ -546076,7 +543042,6 @@ synonym: "up-regulation of calcitonin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of calcitonin secretion" EXACT [GOC:TermGenie]
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
is_a: GO:1904362 ! regulation of calcitonin secretion
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0036161 ! calcitonin secretion
relationship: positively_regulates GO:0036161 ! calcitonin secretion
@@ -546220,7 +543185,6 @@ name: response to kainic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789]
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
is_a: GO:0043200 ! response to amino acid
created_by: sl
creation_date: 2015-06-18T22:42:52Z
@@ -546230,7 +543194,6 @@ id: GO:1904374
name: cellular response to kainic acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904373 ! response to kainic acid
@@ -546696,7 +543659,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-06-23T21:10:45Z
@@ -546706,7 +543668,6 @@ id: GO:1904403
name: cellular response to nocodazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901655 ! cellular response to ketone
@@ -546720,7 +543681,6 @@ name: response to formaldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109]
is_a: GO:0010033 ! response to organic substance
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2015-06-23T21:14:04Z
@@ -546730,7 +543690,6 @@ id: GO:1904405
name: cellular response to formaldehyde
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0110096 ! cellular response to aldehyde
is_a: GO:1904404 ! response to formaldehyde
created_by: sl
@@ -546750,7 +543709,6 @@ synonym: "downregulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of nitric oxide metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of nitric oxide metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -546773,7 +543731,6 @@ synonym: "up-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of nitric oxide metabolism" EXACT [GOC:TermGenie]
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -546787,9 +543744,7 @@ id: GO:1904408
name: melatonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with melatonin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923]
-is_a: GO:0008144 ! drug binding
is_a: GO:0033218 ! amide binding
-is_a: GO:0042562 ! hormone binding
is_a: GO:0097159 ! organic cyclic compound binding
is_a: GO:1901363 ! heterocyclic compound binding
created_by: mr
@@ -548110,27 +545065,28 @@ creation_date: 2015-07-09T19:50:14Z
[Term]
id: GO:1904470
-name: regulation of endothelin secretion
+name: regulation of endothelin production
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
+def: "Any process that modulates the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of EDN3 secretion" NARROW [GOC:TermGenie]
+synonym: "regulation of endothelin secretion" NARROW []
synonym: "regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
-is_a: GO:0050707 ! regulation of cytokine secretion
+is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:1990775 ! endothelin secretion
-relationship: regulates GO:1990775 ! endothelin secretion
+intersection_of: regulates GO:1990775 ! endothelin production
+relationship: regulates GO:1990775 ! endothelin production
created_by: sl
creation_date: 2015-07-09T19:57:57Z
[Term]
id: GO:1904471
-name: negative regulation of endothelin secretion
+name: negative regulation of endothelin production
namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
+def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "down regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of EDN3 secretion" NARROW [GOC:TermGenie]
@@ -548162,22 +545118,23 @@ synonym: "inhibition of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of EDN3 secretion" NARROW [GOC:TermGenie]
+synonym: "negative regulation of endothelin secretion" NARROW []
synonym: "negative regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:1904470 ! regulation of endothelin secretion
+is_a: GO:0001818 ! negative regulation of cytokine production
+is_a: GO:1904470 ! regulation of endothelin production
intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:1990775 ! endothelin secretion
-relationship: negatively_regulates GO:1990775 ! endothelin secretion
+intersection_of: negatively_regulates GO:1990775 ! endothelin production
+relationship: negatively_regulates GO:1990775 ! endothelin production
created_by: sl
creation_date: 2015-07-09T19:58:03Z
[Term]
id: GO:1904472
-name: positive regulation of endothelin secretion
+name: positive regulation of endothelin production
namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
+def: "Any process that activates or increases the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120]
synonym: "activation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "activation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "activation of EDN3 secretion" NARROW [GOC:TermGenie]
@@ -548188,6 +545145,7 @@ synonym: "activation of endothelin-3 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of EDN1 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of EDN2 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of EDN3 secretion" NARROW [GOC:TermGenie]
+synonym: "positive regulation of endothelin secretion" NARROW []
synonym: "positive regulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
@@ -548212,11 +545170,11 @@ synonym: "upregulation of endothelin secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelin-1 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of endothelin-2 secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of endothelin-3 secretion" NARROW [GOC:TermGenie]
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:1904470 ! regulation of endothelin secretion
+is_a: GO:0001819 ! positive regulation of cytokine production
+is_a: GO:1904470 ! regulation of endothelin production
intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:1990775 ! endothelin secretion
-relationship: positively_regulates GO:1990775 ! endothelin secretion
+intersection_of: positively_regulates GO:1990775 ! endothelin production
+relationship: positively_regulates GO:1990775 ! endothelin production
created_by: sl
creation_date: 2015-07-09T19:58:10Z
@@ -548225,9 +545183,7 @@ id: GO:1904473
name: response to L-dopa
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
is_a: GO:0043200 ! response to amino acid
is_a: GO:1904386 ! response to L-phenylalanine derivative
created_by: sl
@@ -548238,10 +545194,8 @@ id: GO:1904474
name: cellular response to L-dopa
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1904387 ! cellular response to L-phenylalanine derivative
is_a: GO:1904473 ! response to L-dopa
created_by: sl
@@ -548358,7 +545312,6 @@ id: GO:1904481
name: response to tetrahydrofolate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:1901700 ! response to oxygen-containing compound
@@ -548370,7 +545323,6 @@ id: GO:1904482
name: cellular response to tetrahydrofolate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160]
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -548401,10 +545353,8 @@ id: GO:1904486
name: response to 17alpha-ethynylestradiol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421]
-is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
-is_a: GO:0042493 ! response to drug
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: mr
creation_date: 2015-07-15T22:31:36Z
@@ -548414,8 +545364,6 @@ id: GO:1904487
name: cellular response to 17alpha-ethynylestradiol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421]
-is_a: GO:0032870 ! cellular response to hormone stimulus
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -549776,7 +546724,6 @@ id: GO:1904555
name: L-proline transmembrane transport
namespace: biological_process
def: "The directed movement of L-proline across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0035524 ! proline transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
created_by: pr
@@ -549787,7 +546734,6 @@ id: GO:1904556
name: L-tryptophan transmembrane transport
namespace: biological_process
def: "The directed movement of L-tryptophan across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015827 ! tryptophan transport
is_a: GO:0098655 ! cation transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
@@ -549810,10 +546756,7 @@ id: GO:1904558
name: response to dextromethorphan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
-is_a: GO:0009410 ! response to xenobiotic stimulus
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0014072 ! response to isoquinoline alkaloid
-is_a: GO:0042493 ! response to drug
is_a: GO:0045472 ! response to ether
created_by: mr
creation_date: 2015-08-14T16:09:17Z
@@ -549823,11 +546766,8 @@ id: GO:1904559
name: cellular response to dextromethorphan
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071317 ! cellular response to isoquinoline alkaloid
is_a: GO:0071362 ! cellular response to ether
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1904558 ! response to dextromethorphan
created_by: mr
creation_date: 2015-08-14T16:09:24Z
@@ -549839,7 +546779,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
is_a: GO:0097305 ! response to alcohol
created_by: mr
creation_date: 2015-08-14T16:09:31Z
@@ -549849,7 +546788,6 @@ id: GO:1904561
name: cellular response to diphenidol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
@@ -550073,7 +547011,7 @@ id: GO:1904576
name: response to tunicamycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
-is_a: GO:0046677 ! response to antibiotic
+is_a: GO:0042221 ! response to chemical
created_by: sl
creation_date: 2015-08-19T18:01:52Z
@@ -550082,7 +547020,7 @@ id: GO:1904577
name: cellular response to tunicamycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379]
-is_a: GO:0071236 ! cellular response to antibiotic
+is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904576 ! response to tunicamycin
created_by: sl
creation_date: 2015-08-19T18:01:58Z
@@ -550665,7 +547603,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "response to PCB 126" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0042493 ! response to drug
created_by: sl
creation_date: 2015-08-27T18:52:49Z
@@ -550675,7 +547612,6 @@ name: cellular response to 3,3',4,4',5-pentachlorobiphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "cellular response to PCB 126" EXACT []
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1904610 ! response to 3,3',4,4',5-pentachlorobiphenyl
created_by: sl
@@ -550688,7 +547624,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
synonym: "response to dioxin" EXACT []
synonym: "response to TCDD" EXACT []
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0014070 ! response to organic cyclic compound
created_by: sl
creation_date: 2015-08-27T19:01:52Z
@@ -550701,7 +547636,6 @@ def: "Any process that results in a change in state or activity of a cell (in te
synonym: "cellular response to dioxin" EXACT []
synonym: "cellular response to TCDD" EXACT []
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
is_a: GO:1904612 ! response to 2,3,7,8-tetrachlorodibenzodioxine
created_by: sl
creation_date: 2015-08-27T19:01:58Z
@@ -550712,7 +547646,6 @@ name: response to biphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0060992 ! response to fungicide
created_by: sl
creation_date: 2015-08-27T19:08:43Z
@@ -550721,9 +547654,7 @@ id: GO:1904615
name: cellular response to biphenyl
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1904614 ! response to biphenyl
created_by: sl
creation_date: 2015-08-27T19:08:49Z
@@ -550792,7 +547723,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812]
synonym: "response to DMSO" EXACT []
is_a: GO:0010033 ! response to organic substance
-is_a: GO:0042493 ! response to drug
created_by: sl
creation_date: 2015-08-27T19:13:49Z
@@ -550802,7 +547732,7 @@ name: cellular response to dimethyl sulfoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812]
synonym: "cellular response to DMSO" EXACT []
-is_a: GO:0035690 ! cellular response to drug
+is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904619 ! response to dimethyl sulfoxide
created_by: sl
creation_date: 2015-08-27T19:14:07Z
@@ -550872,7 +547802,6 @@ def: "Any process that modulates the frequency, rate or extent of glycine secret
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051955 ! regulation of amino acid transport
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0061537 ! glycine secretion, neurotransmission
relationship: regulates GO:0061537 ! glycine secretion, neurotransmission
@@ -550892,7 +547821,6 @@ is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:0060093 ! negative regulation of synaptic transmission, glycinergic
is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission
relationship: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission
@@ -550912,7 +547840,6 @@ is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic
is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0061537 ! glycine secretion, neurotransmission
relationship: positively_regulates GO:0061537 ! glycine secretion, neurotransmission
@@ -550930,7 +547857,6 @@ synonym: "response to tetradecanoylphorbol acetate" EXACT []
synonym: "response to TPA" EXACT []
is_a: GO:0033993 ! response to lipid
is_a: GO:0097305 ! response to alcohol
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-08-28T13:44:03Z
@@ -550944,7 +547870,6 @@ synonym: "cellular response to phorbol 12-tetradecanoate 13-acetate" EXACT []
synonym: "cellular response to response to PMA" EXACT []
synonym: "cellular response to tetradecanoylphorbol acetate" EXACT []
synonym: "cellular response to TPA" EXACT []
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1901655 ! cellular response to ketone
@@ -551121,7 +548046,6 @@ id: GO:1904638
name: response to resveratrol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0035634 ! response to stilbenoid
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
@@ -551133,7 +548057,6 @@ name: cellular response to resveratrol
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904638 ! response to resveratrol
created_by: sl
@@ -551180,8 +548103,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0045472 ! response to ether
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-08-31T20:38:11Z
@@ -551191,8 +548112,6 @@ id: GO:1904644
name: cellular response to curcumin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071362 ! cellular response to ether
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:1901655 ! cellular response to ketone
@@ -551229,8 +548148,6 @@ name: response to rotenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940]
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0017085 ! response to insecticide
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901654 ! response to ketone
created_by: sl
creation_date: 2015-08-31T20:55:32Z
@@ -551240,9 +548157,7 @@ id: GO:1904648
name: cellular response to rotenone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1901655 ! cellular response to ketone
is_a: GO:1904647 ! response to rotenone
created_by: sl
@@ -551705,7 +548620,6 @@ namespace: biological_process
def: "The directed movement of ATP out of a cell or organelle." [GO_REF:0000074, GOC:TermGenie, PMID:24286344]
synonym: "ATP efflux" RELATED []
is_a: GO:0015867 ! ATP transport
-is_a: GO:0046618 ! drug export
created_by: tb
creation_date: 2015-09-09T16:33:06Z
@@ -552155,37 +549069,39 @@ creation_date: 2015-09-29T09:15:28Z
[Term]
id: GO:1904694
-name: negative regulation of vascular smooth muscle contraction
+name: negative regulation of vascular associated smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624]
synonym: "down regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle contraction" NARROW [GOC:TermGenie]
-is_a: GO:0003056 ! regulation of vascular smooth muscle contraction
+synonym: "negative regulation of vascular smooth muscle contraction" EXACT []
+is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction
is_a: GO:0045906 ! negative regulation of vasoconstriction
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0014829 ! vascular smooth muscle contraction
-relationship: negatively_regulates GO:0014829 ! vascular smooth muscle contraction
+intersection_of: negatively_regulates GO:0014829 ! vascular associated smooth muscle contraction
+relationship: negatively_regulates GO:0014829 ! vascular associated smooth muscle contraction
created_by: rph
creation_date: 2015-09-29T13:39:08Z
[Term]
id: GO:1904695
-name: positive regulation of vascular smooth muscle contraction
+name: positive regulation of vascular associated smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624]
synonym: "activation of vascular smooth muscle contraction" NARROW [GOC:TermGenie]
+synonym: "positive regulation of vascular smooth muscle contraction" EXACT []
synonym: "up regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie]
-is_a: GO:0003056 ! regulation of vascular smooth muscle contraction
+is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction
is_a: GO:0045907 ! positive regulation of vasoconstriction
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0014829 ! vascular smooth muscle contraction
-relationship: positively_regulates GO:0014829 ! vascular smooth muscle contraction
+intersection_of: positively_regulates GO:0014829 ! vascular associated smooth muscle contraction
+relationship: positively_regulates GO:0014829 ! vascular associated smooth muscle contraction
created_by: rph
creation_date: 2015-09-29T13:39:14Z
@@ -552370,20 +549286,21 @@ creation_date: 2015-10-01T15:12:02Z
[Term]
id: GO:1904705
-name: regulation of vascular smooth muscle cell proliferation
+name: regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
+synonym: "regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:1990874 ! vascular smooth muscle cell proliferation
-relationship: regulates GO:1990874 ! vascular smooth muscle cell proliferation
+intersection_of: regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
+relationship: regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
created_by: sl
creation_date: 2015-10-01T16:05:20Z
[Term]
id: GO:1904706
-name: negative regulation of vascular smooth muscle cell proliferation
+name: negative regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
@@ -552394,22 +549311,24 @@ synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GO
synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie]
+synonym: "negative regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation
-is_a: GO:1904705 ! regulation of vascular smooth muscle cell proliferation
+is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation
intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:1990874 ! vascular smooth muscle cell proliferation
-relationship: negatively_regulates GO:1990874 ! vascular smooth muscle cell proliferation
+intersection_of: negatively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
+relationship: negatively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
created_by: sl
creation_date: 2015-10-01T16:05:26Z
[Term]
id: GO:1904707
-name: positive regulation of vascular smooth muscle cell proliferation
+name: positive regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie]
+synonym: "positive regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie]
@@ -552418,10 +549337,10 @@ synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation
-is_a: GO:1904705 ! regulation of vascular smooth muscle cell proliferation
+is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation
intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:1990874 ! vascular smooth muscle cell proliferation
-relationship: positively_regulates GO:1990874 ! vascular smooth muscle cell proliferation
+intersection_of: positively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
+relationship: positively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
created_by: sl
creation_date: 2015-10-01T16:05:32Z
@@ -554425,7 +551344,6 @@ synonym: "negative regulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0006744 ! ubiquinone biosynthetic process
@@ -554514,7 +551432,6 @@ synonym: "upregulation of ubiquinone formation" EXACT [GOC:TermGenie]
synonym: "upregulation of ubiquinone synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0006744 ! ubiquinone biosynthetic process
@@ -555120,7 +552037,6 @@ id: GO:1904804
name: response to latrunculin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15537703]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
@@ -555134,7 +552050,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15537703]
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1904804 ! response to latrunculin A
created_by: mah
@@ -555458,7 +552373,6 @@ synonym: "regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
-is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0070814 ! hydrogen sulfide biosynthetic process
relationship: regulates GO:0070814 ! hydrogen sulfide biosynthetic process
@@ -555506,7 +552420,6 @@ synonym: "negative regulation of hydrogen sulphide biosynthesis" EXACT [GOC:Term
synonym: "negative regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process
is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process
@@ -555555,7 +552468,6 @@ synonym: "upregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
-is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process
@@ -555568,7 +552480,7 @@ id: GO:1904829
name: regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
-is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0035887 ! aortic smooth muscle cell differentiation
relationship: regulates GO:0035887 ! aortic smooth muscle cell differentiation
@@ -555585,7 +552497,7 @@ synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [G
synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
-is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
relationship: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
@@ -555602,7 +552514,7 @@ synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC
synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
-is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
relationship: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
@@ -555835,7 +552747,6 @@ synonym: "response to nitroglycerine" EXACT []
synonym: "response to nitroglycerol" EXACT []
synonym: "response to trinitroglycerin" EXACT []
synonym: "response to trinitroglycerol" EXACT []
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0010033 ! response to organic substance
is_a: GO:0042493 ! response to drug
is_a: GO:1901698 ! response to nitrogen compound
@@ -555853,7 +552764,6 @@ synonym: "cellular response to nitroglycerol" EXACT []
synonym: "cellular response to trinitroglycerin" EXACT []
synonym: "cellular response to trinitroglycerol" EXACT []
is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1904842 ! response to nitroglycerin
@@ -555865,8 +552775,6 @@ id: GO:1904844
name: response to L-glutamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570]
-is_a: GO:0007584 ! response to nutrient
-is_a: GO:0042493 ! response to drug
is_a: GO:0043200 ! response to amino acid
created_by: sl
creation_date: 2015-12-07T19:39:17Z
@@ -555876,8 +552784,6 @@ id: GO:1904845
name: cellular response to L-glutamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570]
-is_a: GO:0031670 ! cellular response to nutrient
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1904844 ! response to L-glutamine
created_by: sl
@@ -556576,10 +553482,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591]
synonym: "response to dihydridosulfur" EXACT []
synonym: "response to sulfane" EXACT []
-is_a: GO:0001101 ! response to acid chemical
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0010035 ! response to inorganic substance
-is_a: GO:0042493 ! response to drug
created_by: sl
creation_date: 2016-01-04T23:56:27Z
@@ -556590,9 +553493,7 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591]
synonym: "cellular response to dihydridosulfur" EXACT []
synonym: "cellular response to sulfane" EXACT []
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071229 ! cellular response to acid chemical
-is_a: GO:0097237 ! cellular response to toxic substance
+is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:1904880 ! response to hydrogen sulfide
created_by: sl
creation_date: 2016-01-04T23:56:35Z
@@ -558708,17 +555609,24 @@ creation_date: 2016-02-12T17:57:03Z
id: GO:1904967
name: regulation of monopolar spindle attachment to meiosis I kinetochore
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, PMID:23770679]
+alt_id: GO:0090699
+def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:21920317, PMID:23770679]
+synonym: "correction of merotelic kinetochore attachment, meiosis I" RELATED []
synonym: "regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie]
synonym: "regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT []
synonym: "regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie]
synonym: "regulation of monopolar attachment" EXACT [GOC:TermGenie]
synonym: "regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie]
+synonym: "repair of merotelic kinetochore attachment defect, meiosis I" RELATED []
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
is_a: GO:0060629 ! regulation of homologous chromosome segregation
+is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect
+is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore
+relationship: part_of GO:0043060 ! meiotic metaphase I plate congression
relationship: regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore
+property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18815 xsd:anyURI
created_by: mah
creation_date: 2016-02-15T15:19:12Z
@@ -558899,7 +555807,6 @@ id: GO:1904975
name: response to bleomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781]
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901652 ! response to peptide
created_by: mah
creation_date: 2016-02-18T15:21:23Z
@@ -558909,7 +555816,6 @@ id: GO:1904976
name: cellular response to bleomycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781]
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:1901653 ! cellular response to peptide
is_a: GO:1904975 ! response to bleomycin
created_by: mah
@@ -559019,7 +555925,6 @@ name: glycine import into mitochondrion
namespace: biological_process
def: "The process in which glycine is transported from the cytosol, into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380]
synonym: "transmembrane glycine transport from cytosol to mitochondrion" EXACT []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015816 ! glycine transport
is_a: GO:0043090 ! amino acid import
is_a: GO:0098655 ! cation transmembrane transport
@@ -559538,7 +556443,6 @@ synonym: "regulation of lysine import" BROAD []
synonym: "regulation of lysine uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:1904062 ! regulation of cation transmembrane transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0097639 ! L-lysine import across plasma membrane
relationship: regulates GO:0097639 ! L-lysine import across plasma membrane
@@ -559562,7 +556466,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0097639 ! L-lysine import across plasma membrane
relationship: negatively_regulates GO:0097639 ! L-lysine import across plasma membrane
@@ -559583,7 +556486,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0097639 ! L-lysine import across plasma membrane
relationship: positively_regulates GO:0097639 ! L-lysine import across plasma membrane
@@ -559609,7 +556511,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166]
synonym: "regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:0090357 ! regulation of tryptophan metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan
@@ -559633,7 +556534,6 @@ synonym: "inhibition of de novo NAD biosynthetic process from tryptophan" RELATE
synonym: "negative regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan
@@ -559656,7 +556556,6 @@ synonym: "up-regulation of de novo NAD biosynthetic process from tryptophan" REL
synonym: "upregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie]
synonym: "upregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie]
is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process
-is_a: GO:0051197 ! positive regulation of coenzyme metabolic process
is_a: GO:0090358 ! positive regulation of tryptophan metabolic process
is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan
intersection_of: GO:0008150 ! biological_process
@@ -560783,22 +557682,22 @@ creation_date: 2016-03-21T11:00:23Z
[Term]
id: GO:1905063
-name: regulation of vascular smooth muscle cell differentiation
+name: regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
-synonym: "regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
+synonym: "regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0035886 ! vascular smooth muscle cell differentiation
-relationship: regulates GO:0035886 ! vascular smooth muscle cell differentiation
+intersection_of: regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
+relationship: regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
created_by: rph
creation_date: 2016-03-21T11:14:53Z
[Term]
id: GO:1905064
-name: negative regulation of vascular smooth muscle cell differentiation
+name: negative regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
@@ -560813,26 +557712,26 @@ synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie]
-synonym: "negative regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
+synonym: "negative regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:1901343 ! negative regulation of vasculature development
-is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0035886 ! vascular smooth muscle cell differentiation
-relationship: negatively_regulates GO:0035886 ! vascular smooth muscle cell differentiation
+intersection_of: negatively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
+relationship: negatively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
created_by: rph
creation_date: 2016-03-21T11:15:03Z
[Term]
id: GO:1905065
-name: positive regulation of vascular smooth muscle cell differentiation
+name: positive regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie]
-synonym: "positive regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
+synonym: "positive regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
@@ -560845,10 +557744,10 @@ synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GO
synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:1904018 ! positive regulation of vasculature development
-is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0035886 ! vascular smooth muscle cell differentiation
-relationship: positively_regulates GO:0035886 ! vascular smooth muscle cell differentiation
+intersection_of: positively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
+relationship: positively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
created_by: rph
creation_date: 2016-03-21T11:15:13Z
@@ -561039,113 +557938,6 @@ relationship: positively_regulates GO:1905071 ! tight junction disassembly
created_by: rl
creation_date: 2016-03-23T19:33:10Z
-[Term]
-id: GO:1905076
-name: regulation of interleukin-17 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511]
-comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511 (inferred from direct assay).
-synonym: "regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
-synonym: "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
-synonym: "regulation of IL-17 secretion" EXACT [GOC:TermGenie]
-synonym: "regulation of IL-17A secretion" EXACT [GOC:TermGenie]
-synonym: "regulation of IL17A secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032660 ! regulation of interleukin-17 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0072615 ! interleukin-17 secretion
-relationship: regulates GO:0072615 ! interleukin-17 secretion
-created_by: bhm
-creation_date: 2016-03-24T15:44:21Z
-
-[Term]
-id: GO:1905077
-name: negative regulation of interleukin-17 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511]
-comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511 (inferred from direct assay).
-synonym: "down regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of IL-17 secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of IL-17A secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of IL17A secretion" EXACT [GOC:TermGenie]
-synonym: "down regulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of IL-17 secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of IL-17A secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of IL17A secretion" EXACT [GOC:TermGenie]
-synonym: "down-regulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of IL-17 secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of IL-17A secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of IL17A secretion" EXACT [GOC:TermGenie]
-synonym: "downregulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
-synonym: "inhibition of CTLA-8 secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of Cytotoxic T-lymphocyte-associated antigen 8 secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of IL-17 secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of IL-17A secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of IL17A secretion" NARROW [GOC:TermGenie]
-synonym: "inhibition of interleukin-17 secretion" NARROW [GOC:TermGenie]
-synonym: "negative regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
-synonym: "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
-synonym: "negative regulation of IL-17 secretion" EXACT [GOC:TermGenie]
-synonym: "negative regulation of IL-17A secretion" EXACT [GOC:TermGenie]
-synonym: "negative regulation of IL17A secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032700 ! negative regulation of interleukin-17 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:1905076 ! regulation of interleukin-17 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0072615 ! interleukin-17 secretion
-relationship: negatively_regulates GO:0072615 ! interleukin-17 secretion
-created_by: bhm
-creation_date: 2016-03-24T15:44:31Z
-
-[Term]
-id: GO:1905078
-name: positive regulation of interleukin-17 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511]
-comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511 (inferred from direct assay).
-synonym: "activation of CTLA-8 secretion" NARROW [GOC:TermGenie]
-synonym: "activation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" NARROW [GOC:TermGenie]
-synonym: "activation of IL-17 secretion" NARROW [GOC:TermGenie]
-synonym: "activation of IL-17A secretion" NARROW [GOC:TermGenie]
-synonym: "activation of IL17A secretion" NARROW [GOC:TermGenie]
-synonym: "activation of interleukin-17 secretion" NARROW [GOC:TermGenie]
-synonym: "positive regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
-synonym: "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
-synonym: "positive regulation of IL-17 secretion" EXACT [GOC:TermGenie]
-synonym: "positive regulation of IL-17A secretion" EXACT [GOC:TermGenie]
-synonym: "positive regulation of IL17A secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of IL-17 secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of IL-17A secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of IL17A secretion" EXACT [GOC:TermGenie]
-synonym: "up regulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of IL-17 secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of IL-17A secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of IL17A secretion" EXACT [GOC:TermGenie]
-synonym: "up-regulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of CTLA-8 secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of IL-17 secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of IL-17A secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of IL17A secretion" EXACT [GOC:TermGenie]
-synonym: "upregulation of interleukin-17 secretion" EXACT [GOC:TermGenie]
-is_a: GO:0032740 ! positive regulation of interleukin-17 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:1905076 ! regulation of interleukin-17 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0072615 ! interleukin-17 secretion
-relationship: positively_regulates GO:0072615 ! interleukin-17 secretion
-created_by: bhm
-creation_date: 2016-03-24T15:44:40Z
-
[Term]
id: GO:1905079
name: regulation of cerebellar neuron development
@@ -561384,9 +558176,7 @@ name: response to diosgenin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]
is_a: GO:0036314 ! response to sterol
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:0097305 ! response to alcohol
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1905836 ! response to triterpenoid
created_by: bc
creation_date: 2016-03-31T11:04:28Z
@@ -561396,9 +558186,7 @@ id: GO:1905093
name: cellular response to diosgenin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0036315 ! cellular response to sterol
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0097306 ! cellular response to alcohol
is_a: GO:1905092 ! response to diosgenin
is_a: GO:1905837 ! cellular response to triterpenoid
@@ -561977,7 +558765,6 @@ subset: gocheck_do_not_manually_annotate
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0097305 ! response to alcohol
-is_a: GO:0097332 ! response to antipsychotic drug
is_a: GO:1901654 ! response to ketone
created_by: dw
creation_date: 2016-04-08T12:36:39Z
@@ -561989,7 +558776,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813]
comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:0097306 ! cellular response to alcohol
@@ -562383,7 +559169,6 @@ alt_id: GO:1901689
def: "The directed movement of biotin from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:12557275]
synonym: "biotin import" RELATED []
synonym: "biotin import into cell" EXACT []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015878 ! biotin transport
is_a: GO:0035461 ! vitamin transmembrane transport
is_a: GO:0098657 ! import into cell
@@ -562549,8 +559334,7 @@ id: GO:1905144
name: response to acetylcholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
-is_a: GO:0009725 ! response to hormone
-is_a: GO:0042493 ! response to drug
+is_a: GO:0010033 ! response to organic substance
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: dos
@@ -562561,8 +559345,6 @@ id: GO:1905145
name: cellular response to acetylcholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
-is_a: GO:0032870 ! cellular response to hormone stimulus
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:1901699 ! cellular response to nitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905144 ! response to acetylcholine
@@ -563230,50 +560012,53 @@ creation_date: 2016-05-03T11:00:21Z
[Term]
id: GO:1905174
-name: regulation of vascular smooth muscle cell dedifferentiation
+name: regulation of vascular associated smooth muscle cell dedifferentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
+synonym: "regulation of vascular smooth muscle cell dedifferentiation" EXACT []
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:1900239 ! regulation of phenotypic switching
intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation
-relationship: regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation
+intersection_of: regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation
+relationship: regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation
created_by: rph
creation_date: 2016-05-03T12:31:57Z
[Term]
id: GO:1905175
-name: negative regulation of vascular smooth muscle cell dedifferentiation
+name: negative regulation of vascular associated smooth muscle cell dedifferentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "down regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie]
+synonym: "negative regulation of vascular smooth muscle cell dedifferentiation" EXACT []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1900240 ! negative regulation of phenotypic switching
-is_a: GO:1905174 ! regulation of vascular smooth muscle cell dedifferentiation
+is_a: GO:1905174 ! regulation of vascular associated smooth muscle cell dedifferentiation
intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation
-relationship: negatively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation
+intersection_of: negatively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation
+relationship: negatively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation
created_by: rph
creation_date: 2016-05-03T12:32:05Z
[Term]
id: GO:1905176
-name: positive regulation of vascular smooth muscle cell dedifferentiation
+name: positive regulation of vascular associated smooth muscle cell dedifferentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "activation of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie]
+synonym: "positive regulation of vascular smooth muscle cell dedifferentiation" EXACT []
synonym: "up regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1900241 ! positive regulation of phenotypic switching
-is_a: GO:1905174 ! regulation of vascular smooth muscle cell dedifferentiation
+is_a: GO:1905174 ! regulation of vascular associated smooth muscle cell dedifferentiation
intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation
-relationship: positively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation
+intersection_of: positively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation
+relationship: positively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation
created_by: rph
creation_date: 2016-05-03T12:32:13Z
@@ -563292,7 +560077,6 @@ name: regulation of cardiac muscle tissue regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520]
is_a: GO:0048638 ! regulation of developmental growth
-is_a: GO:0061041 ! regulation of wound healing
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0061026 ! cardiac muscle tissue regeneration
relationship: regulates GO:0061026 ! cardiac muscle tissue regeneration
@@ -563309,7 +560093,6 @@ synonym: "down-regulation of cardiac muscle tissue regeneration" EXACT [GOC:Term
synonym: "downregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac muscle tissue regeneration" NARROW [GOC:TermGenie]
is_a: GO:0048640 ! negative regulation of developmental growth
-is_a: GO:0061045 ! negative regulation of wound healing
is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0061026 ! cardiac muscle tissue regeneration
@@ -563327,7 +560110,6 @@ synonym: "up regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGe
synonym: "up-regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie]
is_a: GO:0048639 ! positive regulation of developmental growth
-is_a: GO:0090303 ! positive regulation of wound healing
is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0061026 ! cardiac muscle tissue regeneration
@@ -563735,7 +560517,6 @@ synonym: "upregulation of hydrogen peroxide-mediated cell death" RELATED [GOC:Te
is_a: GO:1901033 ! positive regulation of response to reactive oxygen species
is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death
is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death
-is_a: GO:2001040 ! positive regulation of cellular response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0036474 ! cell death in response to hydrogen peroxide
relationship: positively_regulates GO:0036474 ! cell death in response to hydrogen peroxide
@@ -563929,7 +560710,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505]
synonym: "response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT []
is_a: GO:0033993 ! response to lipid
-is_a: GO:0061476 ! response to anticoagulant
created_by: sl
creation_date: 2016-06-06T21:30:00Z
@@ -563939,7 +560719,6 @@ name: cellular response to astaxanthin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505]
synonym: "cellular response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT []
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1905217 ! response to astaxanthin
created_by: sl
@@ -564063,7 +560842,7 @@ id: GO:1905226
name: regulation of adhesion of symbiont to host epithelial cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068]
-is_a: GO:0043903 ! regulation of interspecies interactions between organisms
+is_a: GO:0043903 ! regulation of symbiotic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0044651 ! adhesion of symbiont to host epithelial cell
relationship: regulates GO:0044651 ! adhesion of symbiont to host epithelial cell
@@ -564141,8 +560920,6 @@ name: cellular response to L-glutamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25962137]
synonym: "cellular response to L-glutamate(1-)" RELATED []
-is_a: GO:0031670 ! cellular response to nutrient
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1902065 ! response to L-glutamate
created_by: sl
@@ -564153,9 +560930,7 @@ id: GO:1905233
name: response to codeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
-is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0014072 ! response to isoquinoline alkaloid
-is_a: GO:0042493 ! response to drug
created_by: sl
creation_date: 2016-06-07T21:26:45Z
@@ -564164,9 +560939,7 @@ id: GO:1905234
name: cellular response to codeine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071317 ! cellular response to isoquinoline alkaloid
-is_a: GO:0071466 ! cellular response to xenobiotic stimulus
is_a: GO:1905233 ! response to codeine
created_by: sl
creation_date: 2016-06-07T21:26:53Z
@@ -564176,9 +560949,6 @@ id: GO:1905235
name: response to quercetin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
-is_a: GO:0009725 ! response to hormone
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1905395 ! response to flavonoid
created_by: sl
creation_date: 2016-06-07T21:29:40Z
@@ -564188,9 +560958,6 @@ id: GO:1905236
name: cellular response to quercetin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
-is_a: GO:0032870 ! cellular response to hormone stimulus
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:1905235 ! response to quercetin
is_a: GO:1905396 ! cellular response to flavonoid
created_by: sl
@@ -564202,8 +560969,6 @@ name: response to cyclosporin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
synonym: "response to cyclophilin" EXACT []
-is_a: GO:0042493 ! response to drug
-is_a: GO:0046677 ! response to antibiotic
is_a: GO:1901652 ! response to peptide
created_by: sl
creation_date: 2016-06-07T21:32:06Z
@@ -564214,8 +560979,6 @@ name: cellular response to cyclosporin A
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722]
synonym: "cellular response to cyclophilin" EXACT []
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:1901653 ! cellular response to peptide
is_a: GO:1905237 ! response to cyclosporin A
created_by: sl
@@ -564313,7 +561076,6 @@ synonym: "response to Liothyronine" EXACT []
synonym: "response to Liothyroninum" EXACT []
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0043200 ! response to amino acid
-is_a: GO:0097066 ! response to thyroid hormone
created_by: sl
creation_date: 2016-06-08T17:42:04Z
@@ -564327,7 +561089,6 @@ synonym: "cellular response to Liothyronine" EXACT []
synonym: "cellular response to Liothyroninum" EXACT []
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0071407 ! cellular response to organic cyclic compound
-is_a: GO:0097067 ! cellular response to thyroid hormone stimulus
is_a: GO:1905242 ! response to 3,3',5-triiodo-L-thyronine
created_by: sl
creation_date: 2016-06-08T17:42:12Z
@@ -564527,6 +561288,7 @@ name: regulation of RNA binding transcription factor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364]
synonym: "regulation of transcription factor activity" BROAD [GOC:TermGenie]
+is_a: GO:0050789 ! regulation of biological process
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0001070 ! RNA-binding transcription regulator activity
@@ -564544,6 +561306,7 @@ synonym: "down-regulation of RNA binding transcription factor activity" EXACT [G
synonym: "downregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA binding transcription factor activity" NARROW [GOC:TermGenie]
is_a: GO:0044092 ! negative regulation of molecular function
+is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1905255 ! regulation of RNA binding transcription factor activity
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0001070 ! RNA-binding transcription regulator activity
@@ -564561,6 +561324,7 @@ synonym: "up regulation of RNA binding transcription factor activity" EXACT [GOC
synonym: "up-regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie]
is_a: GO:0044093 ! positive regulation of molecular function
+is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1905255 ! regulation of RNA binding transcription factor activity
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0001070 ! RNA-binding transcription regulator activity
@@ -564696,7 +561460,6 @@ namespace: biological_process
def: "The chemical reactions and pathways involving blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S]
synonym: "blasticidin S metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
created_by: pr
creation_date: 2016-06-14T12:47:05Z
@@ -564708,7 +561471,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of blastici
synonym: "blasticidin S breakdown" EXACT [GOC:TermGenie]
synonym: "blasticidin S catabolism" EXACT [GOC:TermGenie]
synonym: "blasticidin S degradation" EXACT [GOC:TermGenie]
-is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0046135 ! pyrimidine nucleoside catabolic process
is_a: GO:1905264 ! blasticidin S metabolic process
created_by: pr
@@ -564723,7 +561485,6 @@ synonym: "blasticidin S anabolism" EXACT [GOC:TermGenie]
synonym: "blasticidin S biosynthesis" EXACT [GOC:TermGenie]
synonym: "blasticidin S formation" EXACT [GOC:TermGenie]
synonym: "blasticidin S synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process
is_a: GO:1905264 ! blasticidin S metabolic process
created_by: pr
@@ -564821,7 +561582,8 @@ synonym: "regulation of hydrogen ion translocating F-type ATPase activity" EXACT
synonym: "regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
is_a: GO:0010155 ! regulation of proton transport
-is_a: GO:0051338 ! regulation of transferase activity
+is_a: GO:0051340 ! regulation of ligase activity
+is_a: GO:2001169 ! regulation of ATP biosynthetic process
is_a: GO:2001257 ! regulation of cation channel activity
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism
@@ -564858,8 +561620,9 @@ synonym: "negative regulation of H+-transporting ATP synthase activity" EXACT [G
synonym: "negative regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
-is_a: GO:0051348 ! negative regulation of transferase activity
+is_a: GO:0051352 ! negative regulation of ligase activity
is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism
+is_a: GO:2001170 ! negative regulation of ATP biosynthetic process
is_a: GO:2001258 ! negative regulation of cation channel activity
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism
@@ -564896,8 +561659,9 @@ synonym: "upregulation of hydrogen ion translocating F-type ATPase activity" EXA
synonym: "upregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
synonym: "upregulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie]
synonym: "upregulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie]
-is_a: GO:0051347 ! positive regulation of transferase activity
+is_a: GO:0051351 ! positive regulation of ligase activity
is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism
+is_a: GO:2001171 ! positive regulation of ATP biosynthetic process
is_a: GO:2001259 ! positive regulation of cation channel activity
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism
@@ -565639,8 +562403,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097327 ! response to antineoplastic agent
created_by: al
creation_date: 2016-07-06T11:55:22Z
@@ -565649,8 +562411,6 @@ id: GO:1905308
name: cellular response to miconazole
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447]
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1905307 ! response to miconazole
@@ -567380,7 +564140,6 @@ def: "Any process that modulates the frequency, rate or extent of creatine trans
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:1903959 ! regulation of anion transmembrane transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0005308 ! creatine transmembrane transporter activity
relationship: regulates GO:0005308 ! creatine transmembrane transporter activity
@@ -567400,7 +564159,6 @@ is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0005308 ! creatine transmembrane transporter activity
relationship: negatively_regulates GO:0005308 ! creatine transmembrane transporter activity
@@ -567420,7 +564178,6 @@ is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0005308 ! creatine transmembrane transporter activity
relationship: positively_regulates GO:0005308 ! creatine transmembrane transporter activity
@@ -567607,35 +564364,20 @@ relationship: positively_regulates GO:0097723 ! amoeboid sperm motility
created_by: pr
creation_date: 2016-09-01T11:29:03Z
-[Term]
-id: GO:1905419
-name: sperm flagellum movement involved in flagellated sperm motility
-namespace: biological_process
-alt_id: GO:0097724
-def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]
-synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc]
-synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie]
-is_a: GO:0022414 ! reproductive process
-is_a: GO:0060294 ! cilium movement involved in cell motility
-intersection_of: GO:0003341 ! cilium movement
-intersection_of: part_of GO:0030317 ! flagellated sperm motility
-relationship: part_of GO:0030317 ! flagellated sperm motility
-created_by: krc
-creation_date: 2016-09-01T17:52:39Z
-
[Term]
id: GO:1905420
-name: vascular smooth muscle cell differentiation involved in phenotypic switching
+name: vascular associated smooth muscle cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any vascular smooth muscle cell differentiation that is involved in phenotypic switching." [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
+synonym: "vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT []
synonym: "VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
-is_a: GO:0035886 ! vascular smooth muscle cell differentiation
+is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation
is_a: GO:0090679 ! cell differentiation involved in phenotypic switching
-intersection_of: GO:0035886 ! vascular smooth muscle cell differentiation
+intersection_of: GO:0035886 ! vascular associated smooth muscle cell differentiation
intersection_of: part_of GO:0090677 ! reversible differentiation
created_by: rph
creation_date: 2016-09-05T12:43:46Z
@@ -568380,8 +565122,6 @@ synonym: "response to aminoacetic acid" EXACT []
synonym: "response to aminoethanoic acid" EXACT []
synonym: "response to Gly" EXACT []
synonym: "response to glycin" EXACT []
-is_a: GO:0007584 ! response to nutrient
-is_a: GO:0042493 ! response to drug
is_a: GO:0043200 ! response to amino acid
created_by: sl
creation_date: 2016-09-08T22:09:15Z
@@ -568395,8 +565135,6 @@ synonym: "cellular response to aminoacetic acid" EXACT []
synonym: "cellular response to aminoethanoic acid" EXACT []
synonym: "cellular response to Gly" EXACT []
synonym: "cellular response to glycin" EXACT []
-is_a: GO:0031670 ! cellular response to nutrient
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:1905429 ! response to glycine
created_by: sl
@@ -568408,7 +565146,6 @@ name: microcystin transport
namespace: biological_process
def: "The directed movement of a microcystin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:TermGenie, PMID:26055554]
is_a: GO:0015833 ! peptide transport
-is_a: GO:1901998 ! toxin transport
created_by: cvs
creation_date: 2016-09-13T23:15:51Z
@@ -568551,7 +565288,6 @@ id: GO:1905439
name: response to chondroitin 6'-sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: cvs
@@ -568562,7 +565298,6 @@ id: GO:1905440
name: cellular response to chondroitin 6'-sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850]
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905439 ! response to chondroitin 6'-sulfate
@@ -568574,7 +565309,6 @@ id: GO:1905441
name: response to chondroitin 4'-sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850]
-is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: cvs
@@ -568585,7 +565319,6 @@ id: GO:1905442
name: cellular response to chondroitin 4'-sulfate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850]
-is_a: GO:0071229 ! cellular response to acid chemical
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
is_a: GO:1905441 ! response to chondroitin 4'-sulfate
@@ -569838,12 +566571,9 @@ creation_date: 2016-09-27T10:50:04Z
id: GO:1905502
name: acetyl-CoA binding
namespace: molecular_function
-def: "Interacting selectively and non-covalently with acetyl-CoA." [GO_REF:0000067, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:24927529]
-is_a: GO:0032559 ! adenyl ribonucleotide binding
-is_a: GO:0033218 ! amide binding
-is_a: GO:0043168 ! anion binding
-is_a: GO:0050662 ! coenzyme binding
-is_a: GO:1901681 ! sulfur compound binding
+def: "Interacting selectively and non-covalently with acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component." [GO_REF:0000067, GOC:bc, GOC:krc, GOC:PARL, GOC:TermGenie, PMID:24927529]
+synonym: "acetyl-coenzyme A binding" EXACT []
+is_a: GO:0120227 ! acyl-CoA binding
created_by: bc
creation_date: 2016-09-27T16:33:44Z
@@ -570444,7 +567174,6 @@ name: regulation of uracil import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126]
is_a: GO:0034762 ! regulation of transmembrane transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0098721 ! uracil import across plasma membrane
relationship: regulates GO:0098721 ! uracil import across plasma membrane
@@ -570458,7 +567187,6 @@ namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1905529 ! regulation of uracil import across plasma membrane
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0098721 ! uracil import across plasma membrane
relationship: negatively_regulates GO:0098721 ! uracil import across plasma membrane
@@ -570472,7 +567200,6 @@ namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1905529 ! regulation of uracil import across plasma membrane
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0098721 ! uracil import across plasma membrane
relationship: positively_regulates GO:0098721 ! uracil import across plasma membrane
@@ -570682,7 +567409,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0097638 ! L-arginine import across plasma membrane
relationship: negatively_regulates GO:0097638 ! L-arginine import across plasma membrane
@@ -570711,7 +567437,6 @@ namespace: biological_process
alt_id: GO:1903813
def: "The directed movement of L-methionine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:17556368]
synonym: "L-methionine import into cell" EXACT []
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport
is_a: GO:1903692 ! methionine import across plasma membrane
created_by: mah
@@ -571879,7 +568604,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0097638 ! L-arginine import across plasma membrane
relationship: positively_regulates GO:0097638 ! L-arginine import across plasma membrane
@@ -572647,7 +569371,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368]
is_a: GO:0010958 ! regulation of amino acid import across plasma membrane
is_a: GO:1904062 ! regulation of cation transmembrane transport
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1905544 ! L-methionine import across plasma membrane
relationship: regulates GO:1905544 ! L-methionine import across plasma membrane
@@ -572663,7 +569386,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:1903960 ! negative regulation of anion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:1905544 ! L-methionine import across plasma membrane
relationship: negatively_regulates GO:1905544 ! L-methionine import across plasma membrane
@@ -572679,7 +569401,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport
is_a: GO:1903961 ! positive regulation of anion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:1905544 ! L-methionine import across plasma membrane
relationship: positively_regulates GO:1905544 ! L-methionine import across plasma membrane
@@ -572695,7 +569416,6 @@ synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -573180,7 +569900,7 @@ id: GO:1905654
name: regulation of artery smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
-is_a: GO:0003056 ! regulation of vascular smooth muscle contraction
+is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0014824 ! artery smooth muscle contraction
relationship: regulates GO:0014824 ! artery smooth muscle contraction
@@ -573196,7 +569916,7 @@ synonym: "down regulation of artery smooth muscle contraction" EXACT [GOC:TermGe
synonym: "down-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of artery smooth muscle contraction" NARROW [GOC:TermGenie]
-is_a: GO:1904694 ! negative regulation of vascular smooth muscle contraction
+is_a: GO:1904694 ! negative regulation of vascular associated smooth muscle contraction
is_a: GO:1905654 ! regulation of artery smooth muscle contraction
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0014824 ! artery smooth muscle contraction
@@ -573213,7 +569933,7 @@ synonym: "activation of artery smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie]
-is_a: GO:1904695 ! positive regulation of vascular smooth muscle contraction
+is_a: GO:1904695 ! positive regulation of vascular associated smooth muscle contraction
is_a: GO:1905654 ! regulation of artery smooth muscle contraction
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0014824 ! artery smooth muscle contraction
@@ -574169,7 +570889,6 @@ id: GO:1905705
name: cellular response to paclitaxel
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18472094]
-is_a: GO:0035690 ! cellular response to drug
is_a: GO:0071396 ! cellular response to lipid
is_a: GO:1901555 ! response to paclitaxel
created_by: sl
@@ -574507,7 +571226,6 @@ name: regulation of L-proline import across plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
is_a: GO:1902834 ! regulation of proline import across plasma membrane
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:1904271 ! L-proline import across plasma membrane
relationship: regulates GO:1904271 ! L-proline import across plasma membrane
@@ -574521,7 +571239,6 @@ namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
is_a: GO:1902835 ! negative regulation of proline import across plasma membrane
is_a: GO:1905735 ! regulation of L-proline import across plasma membrane
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:1904271 ! L-proline import across plasma membrane
relationship: negatively_regulates GO:1904271 ! L-proline import across plasma membrane
@@ -574535,7 +571252,6 @@ namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203]
is_a: GO:1902836 ! positive regulation of proline import across plasma membrane
is_a: GO:1905735 ! regulation of L-proline import across plasma membrane
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:1904271 ! L-proline import across plasma membrane
relationship: positively_regulates GO:1904271 ! L-proline import across plasma membrane
@@ -575539,8 +572255,6 @@ namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288]
synonym: "response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT []
is_a: GO:0014074 ! response to purine-containing compound
-is_a: GO:0046677 ! response to antibiotic
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: sl
creation_date: 2017-01-10T21:13:18Z
@@ -575551,8 +572265,6 @@ name: cellular response to puromycin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288]
synonym: "cellular response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT []
-is_a: GO:0035690 ! cellular response to drug
-is_a: GO:0071236 ! cellular response to antibiotic
is_a: GO:0071407 ! cellular response to organic cyclic compound
is_a: GO:0071417 ! cellular response to organonitrogen compound
is_a: GO:1901701 ! cellular response to oxygen-containing compound
@@ -576531,7 +573243,6 @@ id: GO:1905841
name: response to oxidopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876]
-is_a: GO:0009636 ! response to toxic substance
is_a: GO:0071869 ! response to catecholamine
created_by: pr
creation_date: 2017-01-19T09:49:03Z
@@ -576542,7 +573253,6 @@ name: cellular response to oxidopamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876]
is_a: GO:0071870 ! cellular response to catecholamine stimulus
-is_a: GO:0097237 ! cellular response to toxic substance
is_a: GO:1905841 ! response to oxidopamine
created_by: pr
creation_date: 2017-01-19T09:49:12Z
@@ -578146,7 +574856,7 @@ synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0046885 ! regulation of hormone biosynthetic process
+is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008292 ! acetylcholine biosynthetic process
@@ -578183,7 +574893,7 @@ synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
+is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0060410 ! negative regulation of acetylcholine metabolic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
@@ -578221,7 +574931,7 @@ synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
-is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
+is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
@@ -578335,25 +575045,25 @@ creation_date: 2017-02-08T21:39:14Z
[Term]
id: GO:1905930
-name: regulation of vascular smooth muscle cell differentiation involved in phenotypic switching
+name: regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
-synonym: "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
+synonym: "regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
-is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching
intersection_of: GO:0065007 ! biological regulation
-intersection_of: regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching
-relationship: regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching
+intersection_of: regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching
+relationship: regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching
created_by: rph
creation_date: 2017-02-09T09:20:59Z
[Term]
id: GO:1905931
-name: negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching
+name: negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
@@ -578383,20 +575093,21 @@ synonym: "inhibition of VSMC differentiation involved in phenotypic switching" N
synonym: "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
+synonym: "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT []
synonym: "negative regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "negative regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
-is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905916 ! negative regulation of cell differentiation involved in phenotypic switching
-is_a: GO:1905930 ! regulation of vascular smooth muscle cell differentiation involved in phenotypic switching
+is_a: GO:1905930 ! regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
intersection_of: GO:0065007 ! biological regulation
-intersection_of: negatively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching
-relationship: negatively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching
+intersection_of: negatively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching
+relationship: negatively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching
created_by: rph
creation_date: 2017-02-09T09:21:08Z
[Term]
id: GO:1905932
-name: positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching
+name: positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138]
synonym: "activation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
@@ -578406,8 +575117,8 @@ synonym: "activation of vascular smooth muscle cell differentiation involved in
synonym: "activation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "activation of VSMC differentiation involved in phenotypic switching" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
-synonym: "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
+synonym: "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "positive regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
@@ -578428,12 +575139,12 @@ synonym: "upregulation of vascular smooth muscle cell differentiation involved i
synonym: "upregulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie]
synonym: "upregulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie]
-is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905917 ! positive regulation of cell differentiation involved in phenotypic switching
-is_a: GO:1905930 ! regulation of vascular smooth muscle cell differentiation involved in phenotypic switching
+is_a: GO:1905930 ! regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
intersection_of: GO:0065007 ! biological regulation
-intersection_of: positively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching
-relationship: positively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching
+intersection_of: positively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching
+relationship: positively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching
created_by: rph
creation_date: 2017-02-09T09:21:17Z
@@ -578970,8 +575681,8 @@ def: "Catalysis of the reaction: IDP + H2O = IMP + phosphate." [PMID:20385596, P
synonym: "IDPase activity" EXACT []
synonym: "inosine diphosphatase activity" EXACT []
synonym: "inosine-diphosphatase activity" EXACT []
-xref: EC:3.1.3
xref: Reactome:R-HSA-2509816 "NUDT16 hydrolyses IDP to IMP"
+xref: RHEA:35207
is_a: GO:0017110 ! nucleoside-diphosphatase activity
is_a: GO:0098519 ! nucleotide phosphatase activity, acting on free nucleotides
created_by: jl
@@ -579522,7 +576233,6 @@ comment: Note that this term is in the subset of terms that should not be used f
subset: gocheck_do_not_manually_annotate
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0014070 ! response to organic cyclic compound
-is_a: GO:0097327 ! response to antineoplastic agent
is_a: GO:1901700 ! response to oxygen-containing compound
created_by: pr
creation_date: 2013-02-22T10:09:44Z
@@ -579534,6 +576244,7 @@ namespace: molecular_function
def: "Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2." [MetaCyc:RXN-8990, PMID:16766535, PMID:23204519]
synonym: "aromatic aldehyde synthase" BROAD []
xref: EC:4.1.1.109
+xref: RHEA:55532
is_a: GO:0016831 ! carboxy-lyase activity
created_by: tb
creation_date: 2013-02-25T20:22:35Z
@@ -579868,6 +576579,7 @@ name: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltran
namespace: molecular_function
def: "Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methanol-specific corrinoid protein]." [GOC:hjd, PMID:10077852]
xref: EC:2.1.1.246
+xref: RHEA:45208
is_a: GO:0008168 ! methyltransferase activity
created_by: hjd
creation_date: 2013-05-06T15:07:20Z
@@ -582866,7 +579578,7 @@ creation_date: 2014-05-28T18:43:21Z
id: GO:1990385
name: meiotic spindle midzone
namespace: cellular_component
-def: "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv\,PMID\:12707312]
+def: "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv, PMID:12707312]
is_a: GO:0051233 ! spindle midzone
relationship: part_of GO:0072687 ! meiotic spindle
created_by: kmv
@@ -583026,6 +579738,7 @@ def: "The regrowth of lost or destroyed epithelium." [GOC:sl, PMID:19845688]
synonym: "regeneration of epithelium" EXACT []
is_a: GO:0042246 ! tissue regeneration
is_a: GO:0060429 ! epithelium development
+relationship: part_of GO:0042060 ! wound healing
created_by: sl
creation_date: 2014-06-12T17:14:42Z
@@ -583190,7 +579903,7 @@ creation_date: 2014-07-03T21:26:24Z
id: GO:1990414
name: replication-born double-strand break repair via sister chromatid exchange
namespace: biological_process
-def: "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [PMID:12820977, PMID:16888651\,GOC\:rb]
+def: "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651]
synonym: "replication-born DSB repair by SCE" EXACT []
is_a: GO:0000724 ! double-strand break repair via homologous recombination
created_by: rb
@@ -584613,7 +581326,6 @@ id: GO:1990544
name: mitochondrial ATP transmembrane transport
namespace: biological_process
def: "The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:18485069]
-is_a: GO:0006855 ! drug transmembrane transport
is_a: GO:0015867 ! ATP transport
is_a: GO:0072530 ! purine-containing compound transmembrane transport
is_a: GO:0098656 ! anion transmembrane transport
@@ -585205,19 +581917,6 @@ is_a: GO:0032991 ! protein-containing complex
created_by: bf
creation_date: 2015-01-05T15:14:35Z
-[Term]
-id: GO:1990598
-name: repair of mitotic mono-orientation defect
-namespace: biological_process
-def: "The mitotic cell cycle process where mono-orientation defects are corrected in order to ensure sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. Mono-orientation defects occur when both sister kinetochores are attached to MTs from one spindle pole in mitosis and meiosis II." [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536]
-synonym: "correction of mono-orientation defects" EXACT []
-synonym: "correction of syntelic kinetochore attachment, mitotic" EXACT [GOC:vw]
-synonym: "repair of mitotic mono-orientation defects" EXACT []
-is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling
-is_a: GO:0140273 ! repair of mitotic kinetochore microtubule attachment defect
-created_by: jl
-creation_date: 2015-01-05T16:54:39Z
-
[Term]
id: GO:1990599
name: 3' overhang single-stranded DNA endodeoxyribonuclease activity
@@ -585315,6 +582014,7 @@ namespace: biological_process
alt_id: GO:0070632
alt_id: GO:0071789
def: "A process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location." [PMID:24963130]
+synonym: "establishment and maintenance of spindle pole body localization" EXACT []
synonym: "establishment of spindle pole body localisation" NARROW [GOC:mah]
synonym: "establishment of spindle pole body localization" NARROW []
synonym: "mitotic spindle pole body localization to nuclear envelope" NARROW []
@@ -586759,9 +583459,10 @@ creation_date: 2015-04-29T14:40:20Z
[Term]
id: GO:1990736
-name: regulation of vascular smooth muscle cell membrane depolarization
+name: regulation of vascular associated smooth muscle cell membrane depolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell." [PMID:20826763]
+synonym: "regulation of vascular smooth muscle cell membrane depolarization" EXACT []
is_a: GO:0051899 ! membrane depolarization
created_by: sl
creation_date: 2015-04-29T22:33:19Z
@@ -586786,6 +583487,7 @@ name: pseudouridine 5'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate." [EC:3.1.3.96, PMID:20722631]
xref: EC:3.1.3.96
+xref: RHEA:10944
is_a: GO:0016791 ! phosphatase activity
created_by: vw
creation_date: 2015-05-02T11:05:50Z
@@ -587149,16 +583851,17 @@ creation_date: 2015-06-15T22:59:26Z
[Term]
id: GO:1990775
-name: endothelin secretion
+name: endothelin production
namespace: biological_process
-def: "The regulated release of endothelin from a cell. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120]
-synonym: "EDN1 secretion" NARROW []
-synonym: "EDN2 secretion" NARROW []
-synonym: "EDN3 secretion" NARROW []
+def: "The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120]
+synonym: "EDN1 production" NARROW []
+synonym: "EDN2 production" NARROW []
+synonym: "EDN3 production" NARROW []
+synonym: "endothelin secretion" NARROW []
synonym: "endothelin-1 secretion" NARROW []
-synonym: "endothelin-2 secretion" NARROW []
-synonym: "endothelin-3 secretion" NARROW []
-is_a: GO:0050663 ! cytokine secretion
+synonym: "endothelin-2 production" NARROW []
+synonym: "endothelin-3 production" NARROW []
+is_a: GO:0001816 ! cytokine production
created_by: sl
creation_date: 2015-06-15T23:13:18Z
@@ -587631,7 +584334,6 @@ name: L-arginine transmembrane export from vacuole
namespace: biological_process
def: "The directed movement of L-arginine out of the vacuole, across the vacuolar membrane." [PMID:26083598]
is_a: GO:0032974 ! amino acid transmembrane export from vacuole
-is_a: GO:0046618 ! drug export
is_a: GO:1903400 ! L-arginine transmembrane transport
created_by: vw
creation_date: 2015-08-06T15:06:33Z
@@ -588223,9 +584925,10 @@ creation_date: 2015-09-29T10:06:25Z
[Term]
id: GO:1990874
-name: vascular smooth muscle cell proliferation
+name: vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467]
+synonym: "vascular smooth muscle cell proliferation" EXACT []
synonym: "VSMC proliferation" EXACT []
is_a: GO:0048659 ! smooth muscle cell proliferation
created_by: sl
@@ -588436,7 +585139,7 @@ creation_date: 2015-11-04T20:25:21Z
id: GO:1990895
name: regulation of protein localization to cell cortex of cell tip
namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip." [PMID:26150232\,GOC\:vw]
+def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip." [GOC:vw, PMID:26150232]
is_a: GO:1903066 ! regulation of protein localization to cell tip
is_a: GO:1904776 ! regulation of protein localization to cell cortex
intersection_of: GO:0008150 ! biological_process
@@ -588704,7 +585407,10 @@ namespace: molecular_function
def: "The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome." [PMID:16096059]
synonym: "nuclear membrane proteasome adaptor" RELATED []
synonym: "nuclear membrane proteasome anchor" EXACT []
+synonym: "nuclear membrane proteasome tether" EXACT []
+synonym: "nuclear membrane proteasome tether activity" EXACT []
synonym: "nuclear membrane-proteasome anchor activity" EXACT []
+synonym: "nuclear membrane-proteasome tether activity" EXACT []
synonym: "tethering factor for nuclear proteasome" RELATED []
is_a: GO:0043495 ! protein-membrane adaptor activity
property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19119 xsd:anyURI
@@ -588862,9 +585568,10 @@ creation_date: 2016-03-21T21:57:20Z
[Term]
id: GO:1990936
-name: vascular smooth muscle cell dedifferentiation
+name: vascular associated smooth muscle cell dedifferentiation
namespace: biological_process
def: "The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19088079]
+synonym: "vascular smooth muscle cell dedifferentiation" EXACT []
is_a: GO:0090678 ! cell dedifferentiation involved in phenotypic switching
created_by: tb
creation_date: 2016-03-22T20:25:11Z
@@ -589808,7 +586515,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway." [GOC:obol]
synonym: "regulation of salicylic acid mediated signalling pathway" EXACT [GOC:obol]
is_a: GO:0009966 ! regulation of signal transduction
-is_a: GO:2001038 ! regulation of cellular response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0009863 ! salicylic acid mediated signaling pathway
relationship: regulates GO:0009863 ! salicylic acid mediated signaling pathway
@@ -590626,7 +587332,6 @@ is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0019853 ! L-ascorbic acid biosynthetic process
relationship: regulates GO:0019853 ! L-ascorbic acid biosynthetic process
@@ -590649,7 +587354,6 @@ synonym: "negative regulation of vitamin C biosynthetic process" EXACT [GOC:obol
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:2000082 ! regulation of L-ascorbic acid biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0019853 ! L-ascorbic acid biosynthetic process
@@ -592713,7 +589417,6 @@ name: regulation of testosterone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf]
is_a: GO:0010566 ! regulation of ketone biosynthetic process
-is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0061370 ! testosterone biosynthetic process
@@ -592727,7 +589430,7 @@ name: negative regulation of testosterone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
-is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
+is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2000224 ! regulation of testosterone biosynthetic process
intersection_of: GO:0008150 ! biological_process
@@ -594470,7 +591173,12 @@ creation_date: 2011-02-01T10:46:33Z
id: GO:2000341
name: regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
+alt_id: GO:0035926
+alt_id: GO:1904207
def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]
+synonym: "chemokine (C-C motif) ligand 2 secretion" NARROW []
+synonym: "regulation of CCL2 secretion" NARROW [GOC:TermGenie]
+synonym: "regulation of chemokine (C-C motif) ligand 2 secretion" NARROW []
synonym: "regulation of CXCL2 production" EXACT [GOC:obol]
synonym: "regulation of MIP-2 production" EXACT [GOC:obol]
synonym: "regulation of MIP2 production" EXACT [GOC:obol]
@@ -594486,7 +591194,11 @@ creation_date: 2011-02-01T11:57:14Z
id: GO:2000342
name: negative regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
+alt_id: GO:1904208
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]
+synonym: "inhibition of CCL2 secretion" NARROW [GOC:TermGenie]
+synonym: "inhibition of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie]
+synonym: "negative regulation of chemokine (C-C motif) ligand 2 secretion" NARROW []
synonym: "negative regulation of CXCL2 production" EXACT [GOC:obol]
synonym: "negative regulation of MIP-2 production" EXACT [GOC:obol]
synonym: "negative regulation of MIP2 production" EXACT [GOC:obol]
@@ -594503,7 +591215,10 @@ creation_date: 2011-02-01T11:57:17Z
id: GO:2000343
name: positive regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
+alt_id: GO:1904209
def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]
+synonym: "positive regulation of CCL2 secretion" EXACT [GOC:TermGenie]
+synonym: "positive regulation of chemokine (C-C motif) ligand 2 secretion" NARROW []
synonym: "positive regulation of CXCL2 production" EXACT [GOC:obol]
synonym: "positive regulation of MIP-2 production" EXACT [GOC:obol]
synonym: "positive regulation of MIP2 production" EXACT [GOC:obol]
@@ -596582,50 +593297,6 @@ relationship: positively_regulates GO:0004691 ! cAMP-dependent protein kinase ac
created_by: yaf
creation_date: 2011-03-10T11:14:17Z
-[Term]
-id: GO:2000482
-name: regulation of interleukin-8 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-8 secretion." [GOC:obol]
-synonym: "regulation of IL-8 secretion" EXACT [GOC:obol]
-is_a: GO:0032677 ! regulation of interleukin-8 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0072606 ! interleukin-8 secretion
-relationship: regulates GO:0072606 ! interleukin-8 secretion
-created_by: yaf
-creation_date: 2011-03-10T02:37:11Z
-
-[Term]
-id: GO:2000483
-name: negative regulation of interleukin-8 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion." [GOC:obol]
-synonym: "negative regulation of IL-8 secretion" EXACT [GOC:obol]
-is_a: GO:0032717 ! negative regulation of interleukin-8 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:2000482 ! regulation of interleukin-8 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0072606 ! interleukin-8 secretion
-relationship: negatively_regulates GO:0072606 ! interleukin-8 secretion
-created_by: yaf
-creation_date: 2011-03-10T02:37:51Z
-
-[Term]
-id: GO:2000484
-name: positive regulation of interleukin-8 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion." [GOC:obol]
-synonym: "positive regulation of IL-8 secretion" EXACT [GOC:obol]
-is_a: GO:0032757 ! positive regulation of interleukin-8 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:2000482 ! regulation of interleukin-8 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0072606 ! interleukin-8 secretion
-relationship: positively_regulates GO:0072606 ! interleukin-8 secretion
-created_by: yaf
-creation_date: 2011-03-10T02:38:20Z
-
[Term]
id: GO:2000485
name: regulation of glutamine transport
@@ -597592,11 +594263,12 @@ creation_date: 2011-04-03T07:52:17Z
[Term]
id: GO:2000559
-name: regulation of CD24 biosynthetic process
+name: regulation of CD24 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol]
synonym: "regulation of CD24 anabolism" EXACT [GOC:obol]
synonym: "regulation of CD24 biosynthesis" EXACT [GOC:obol]
+synonym: "regulation of CD24 biosynthetic process" EXACT []
synonym: "regulation of CD24 formation" EXACT [GOC:obol]
synonym: "regulation of CD24 synthesis" EXACT [GOC:obol]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
@@ -597608,15 +594280,16 @@ creation_date: 2011-04-03T08:56:56Z
[Term]
id: GO:2000560
-name: positive regulation of CD24 biosynthetic process
+name: positive regulation of CD24 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol]
synonym: "positive regulation of CD24 anabolism" EXACT [GOC:obol]
synonym: "positive regulation of CD24 biosynthesis" EXACT [GOC:obol]
+synonym: "positive regulation of CD24 biosynthetic process" EXACT []
synonym: "positive regulation of CD24 formation" EXACT [GOC:obol]
synonym: "positive regulation of CD24 synthesis" EXACT [GOC:obol]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
-is_a: GO:2000559 ! regulation of CD24 biosynthetic process
+is_a: GO:2000559 ! regulation of CD24 production
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0035724 ! CD24 biosynthetic process
relationship: positively_regulates GO:0035724 ! CD24 biosynthetic process
@@ -598720,7 +595393,6 @@ def: "Any process that activates or increases the frequency, rate or extent of g
synonym: "positive regulation of gene silencing by microRNA" RELATED [GOC:pr]
synonym: "positive regulation of microRNA-mediated gene silencing" EXACT [GOC:obol]
synonym: "positive regulation of miRNA-mediated gene silencing" EXACT [GOC:obol]
-is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing
is_a: GO:0060964 ! regulation of gene silencing by miRNA
intersection_of: GO:0008150 ! biological_process
@@ -599089,94 +595761,6 @@ relationship: positively_regulates GO:0070498 ! interleukin-1-mediated signaling
created_by: dph
creation_date: 2011-05-03T07:13:40Z
-[Term]
-id: GO:2000662
-name: regulation of interleukin-5 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-5 secretion." [GOC:obol]
-synonym: "regulation of IL-5 secretion" EXACT [GOC:obol]
-is_a: GO:0032674 ! regulation of interleukin-5 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0072603 ! interleukin-5 secretion
-relationship: regulates GO:0072603 ! interleukin-5 secretion
-created_by: yaf
-creation_date: 2011-05-06T02:59:02Z
-
-[Term]
-id: GO:2000663
-name: negative regulation of interleukin-5 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-5 secretion." [GOC:obol]
-synonym: "negative regulation of IL-5 secretion" EXACT [GOC:obol]
-is_a: GO:0032714 ! negative regulation of interleukin-5 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:2000662 ! regulation of interleukin-5 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0072603 ! interleukin-5 secretion
-relationship: negatively_regulates GO:0072603 ! interleukin-5 secretion
-created_by: yaf
-creation_date: 2011-05-06T02:59:05Z
-
-[Term]
-id: GO:2000664
-name: positive regulation of interleukin-5 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-5 secretion." [GOC:obol]
-synonym: "positive regulation of IL-5 secretion" EXACT [GOC:obol]
-is_a: GO:0032754 ! positive regulation of interleukin-5 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:2000662 ! regulation of interleukin-5 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0072603 ! interleukin-5 secretion
-relationship: positively_regulates GO:0072603 ! interleukin-5 secretion
-created_by: yaf
-creation_date: 2011-05-06T02:59:07Z
-
-[Term]
-id: GO:2000665
-name: regulation of interleukin-13 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-13 secretion." [GOC:obol]
-synonym: "regulation of IL-13 secretion" EXACT [GOC:obol]
-is_a: GO:0032656 ! regulation of interleukin-13 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0072611 ! interleukin-13 secretion
-relationship: regulates GO:0072611 ! interleukin-13 secretion
-created_by: yaf
-creation_date: 2011-05-06T03:24:19Z
-
-[Term]
-id: GO:2000666
-name: negative regulation of interleukin-13 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-13 secretion." [GOC:obol]
-synonym: "negative regulation of IL-13 secretion" EXACT [GOC:obol]
-is_a: GO:0032696 ! negative regulation of interleukin-13 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:2000665 ! regulation of interleukin-13 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0072611 ! interleukin-13 secretion
-relationship: negatively_regulates GO:0072611 ! interleukin-13 secretion
-created_by: yaf
-creation_date: 2011-05-06T03:24:22Z
-
-[Term]
-id: GO:2000667
-name: positive regulation of interleukin-13 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-13 secretion." [GOC:obol]
-synonym: "positive regulation of IL-13 secretion" EXACT [GOC:obol]
-is_a: GO:0032736 ! positive regulation of interleukin-13 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:2000665 ! regulation of interleukin-13 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0072611 ! interleukin-13 secretion
-relationship: positively_regulates GO:0072611 ! interleukin-13 secretion
-created_by: yaf
-creation_date: 2011-05-06T03:24:25Z
-
[Term]
id: GO:2000668
name: regulation of dendritic cell apoptotic process
@@ -600027,7 +596611,7 @@ name: regulation of cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF]
synonym: "regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol]
-is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905207 ! regulation of cardiocyte differentiation
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation
@@ -600041,7 +596625,7 @@ name: negative regulation of cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF]
synonym: "negative regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol]
-is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation
intersection_of: GO:0008150 ! biological_process
@@ -600056,7 +596640,7 @@ name: positive regulation of cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF]
synonym: "positive regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol]
-is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation
+is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation
is_a: GO:1905209 ! positive regulation of cardiocyte differentiation
is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation
intersection_of: GO:0008150 ! biological_process
@@ -600870,20 +597454,6 @@ relationship: part_of GO:0071456 ! cellular response to hypoxia
created_by: mah
creation_date: 2011-06-22T04:07:20Z
-[Term]
-id: GO:2000778
-name: positive regulation of interleukin-6 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion." [GOC:BHF]
-synonym: "positive regulation of IL-6 secretion" EXACT [GOC:obol]
-is_a: GO:0032755 ! positive regulation of interleukin-6 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0072604 ! interleukin-6 secretion
-relationship: positively_regulates GO:0072604 ! interleukin-6 secretion
-created_by: vk
-creation_date: 2011-06-22T08:27:45Z
-
[Term]
id: GO:2000779
name: regulation of double-strand break repair
@@ -602146,7 +598716,6 @@ synonym: "regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [
synonym: "regulation of folliculin secretion" EXACT [GOC:obol]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0046883 ! regulation of hormone secretion
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0035943 ! estrone secretion
relationship: regulates GO:0035943 ! estrone secretion
@@ -602163,7 +598732,6 @@ synonym: "negative regulation of folliculin secretion" EXACT [GOC:obol]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:2000867 ! regulation of estrone secretion
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0035943 ! estrone secretion
relationship: negatively_regulates GO:0035943 ! estrone secretion
@@ -602180,7 +598748,6 @@ synonym: "positive regulation of folliculin secretion" EXACT [GOC:obol]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:2000867 ! regulation of estrone secretion
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0035943 ! estrone secretion
relationship: positively_regulates GO:0035943 ! estrone secretion
@@ -602194,7 +598761,6 @@ namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of progesterone secretion." [GOC:sl]
is_a: GO:2000194 ! regulation of female gonad development
is_a: GO:2000831 ! regulation of steroid hormone secretion
-is_a: GO:2001023 ! regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: regulates GO:0042701 ! progesterone secretion
relationship: regulates GO:0042701 ! progesterone secretion
@@ -602209,7 +598775,6 @@ def: "Any process that stops, prevents or reduces the frequency, rate or extent
is_a: GO:2000195 ! negative regulation of female gonad development
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000870 ! regulation of progesterone secretion
-is_a: GO:2001024 ! negative regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0042701 ! progesterone secretion
relationship: negatively_regulates GO:0042701 ! progesterone secretion
@@ -602224,7 +598789,6 @@ def: "Any process that activates or increases the frequency, rate or extent of p
is_a: GO:2000196 ! positive regulation of female gonad development
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000870 ! regulation of progesterone secretion
-is_a: GO:2001025 ! positive regulation of response to drug
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0042701 ! progesterone secretion
relationship: positively_regulates GO:0042701 ! progesterone secretion
@@ -602403,7 +598967,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of a glucom
synonym: "glucomannan catabolism" EXACT [GOC:obol]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0010391 ! glucomannan metabolic process
-is_a: GO:0042737 ! drug catabolic process
created_by: jl
creation_date: 2011-07-28T09:19:03Z
@@ -602558,7 +599121,6 @@ name: regulation of glucomannan catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators]
synonym: "regulation of glucomannan catabolism" EXACT [GOC:obol]
-is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
intersection_of: GO:0008150 ! biological_process
@@ -602673,8 +599235,8 @@ name: negative regulation of glucomannan catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators]
synonym: "negative regulation of glucomannan catabolism" EXACT [GOC:obol]
+is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
-is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:2000898 ! regulation of glucomannan catabolic process
intersection_of: GO:0008150 ! biological_process
@@ -604174,9 +600736,9 @@ def: "Any process that stops, prevents or reduces the frequency, rate or extent
synonym: "negative regulation of pectin breakdown" EXACT [GOC:obol]
synonym: "negative regulation of pectin catabolism" EXACT [GOC:obol]
synonym: "negative regulation of pectin degradation" EXACT [GOC:obol]
+is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
-is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:2001003 ! regulation of pectin catabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: negatively_regulates GO:0045490 ! pectin catabolic process
@@ -604192,9 +600754,9 @@ def: "Any process that activates or increases the frequency, rate or extent of p
synonym: "positive regulation of pectin breakdown" EXACT [GOC:obol]
synonym: "positive regulation of pectin catabolism" EXACT [GOC:obol]
synonym: "positive regulation of pectin degradation" EXACT [GOC:obol]
+is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
-is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:2001003 ! regulation of pectin catabolic process
intersection_of: GO:0008150 ! biological_process
intersection_of: positively_regulates GO:0045490 ! pectin catabolic process
@@ -604975,7 +601537,6 @@ id: GO:2001063
name: glucomannan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glucomannan." [GOC:mengo_curators]
-is_a: GO:0008144 ! drug binding
is_a: GO:0010297 ! heteropolysaccharide binding
created_by: jl
creation_date: 2011-09-14T10:29:45Z
@@ -605602,7 +602163,6 @@ name: coenzyme gamma-F420-2 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a coenzyme gamma-F420-2." [GOC:mengo_curators]
synonym: "coenzyme gamma-F420-2 biosynthesis" EXACT [GOC:obol]
-is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0052649 ! coenzyme gamma-F420-2 metabolic process
is_a: GO:0072351 ! tricarboxylic acid biosynthetic process
@@ -605729,7 +602289,6 @@ namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a 3-(methylthio)propionic acid." [GOC:mengo_curators]
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0015948 ! methanogenesis
created_by: jl
creation_date: 2011-10-13T12:19:33Z
@@ -605750,8 +602309,6 @@ name: methane biosynthetic process from carbon monoxide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a methane from a carbon monoxide." [GOC:mengo_curators]
is_a: GO:0015948 ! methanogenesis
-is_a: GO:0017144 ! drug metabolic process
-is_a: GO:0042133 ! neurotransmitter metabolic process
created_by: jl
creation_date: 2011-10-13T12:36:20Z
@@ -605862,8 +602419,6 @@ name: nicotinate transport
namespace: biological_process
def: "The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol]
is_a: GO:0015718 ! monocarboxylic acid transport
-is_a: GO:0015893 ! drug transport
-is_a: GO:0051180 ! vitamin transport
is_a: GO:0071705 ! nitrogen compound transport
created_by: tb
creation_date: 2011-10-18T05:09:50Z
@@ -606394,106 +602949,6 @@ relationship: positively_regulates GO:0036034 ! mediator complex assembly
created_by: yaf
creation_date: 2011-11-02T11:22:27Z
-[Term]
-id: GO:2001179
-name: regulation of interleukin-10 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-10 secretion." [GOC:obol]
-synonym: "regulation of IL-10 secretion" EXACT [GOC:obol]
-is_a: GO:0032653 ! regulation of interleukin-10 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0072608 ! interleukin-10 secretion
-relationship: regulates GO:0072608 ! interleukin-10 secretion
-created_by: yaf
-creation_date: 2011-11-03T10:53:48Z
-
-[Term]
-id: GO:2001180
-name: negative regulation of interleukin-10 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion." [GOC:obol]
-synonym: "negative regulation of IL-10 secretion" EXACT [GOC:obol]
-is_a: GO:0032693 ! negative regulation of interleukin-10 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:2001179 ! regulation of interleukin-10 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0072608 ! interleukin-10 secretion
-relationship: negatively_regulates GO:0072608 ! interleukin-10 secretion
-created_by: yaf
-creation_date: 2011-11-03T10:53:54Z
-
-[Term]
-id: GO:2001181
-name: positive regulation of interleukin-10 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-10 secretion." [GOC:obol]
-synonym: "positive regulation of IL-10 secretion" EXACT [GOC:obol]
-is_a: GO:0032733 ! positive regulation of interleukin-10 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:2001179 ! regulation of interleukin-10 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0072608 ! interleukin-10 secretion
-relationship: positively_regulates GO:0072608 ! interleukin-10 secretion
-created_by: yaf
-creation_date: 2011-11-03T10:53:58Z
-
-[Term]
-id: GO:2001182
-name: regulation of interleukin-12 secretion
-namespace: biological_process
-def: "Any process that modulates the frequency, rate or extent of interleukin-12 secretion." [GOC:obol]
-synonym: "regulation of CLMF secretion" RELATED [GOC:obol]
-synonym: "regulation of IL-12 secretion" EXACT [GOC:obol]
-synonym: "regulation of IL12 secretion" EXACT [GOC:obol]
-synonym: "regulation of interleukin-12 complex secretion" EXACT [GOC:obol]
-synonym: "regulation of NKSF secretion" RELATED [GOC:obol]
-is_a: GO:0032655 ! regulation of interleukin-12 production
-is_a: GO:0050707 ! regulation of cytokine secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: regulates GO:0072610 ! interleukin-12 secretion
-relationship: regulates GO:0072610 ! interleukin-12 secretion
-created_by: yaf
-creation_date: 2011-11-03T01:10:29Z
-
-[Term]
-id: GO:2001183
-name: negative regulation of interleukin-12 secretion
-namespace: biological_process
-def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-12 secretion." [GOC:obol]
-synonym: "negative regulation of CLMF secretion" RELATED [GOC:obol]
-synonym: "negative regulation of IL-12 secretion" EXACT [GOC:obol]
-synonym: "negative regulation of IL12 secretion" EXACT [GOC:obol]
-synonym: "negative regulation of interleukin-12 complex secretion" EXACT [GOC:obol]
-synonym: "negative regulation of NKSF secretion" RELATED [GOC:obol]
-is_a: GO:0032695 ! negative regulation of interleukin-12 production
-is_a: GO:0050710 ! negative regulation of cytokine secretion
-is_a: GO:2001182 ! regulation of interleukin-12 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: negatively_regulates GO:0072610 ! interleukin-12 secretion
-relationship: negatively_regulates GO:0072610 ! interleukin-12 secretion
-created_by: yaf
-creation_date: 2011-11-03T01:10:37Z
-
-[Term]
-id: GO:2001184
-name: positive regulation of interleukin-12 secretion
-namespace: biological_process
-def: "Any process that activates or increases the frequency, rate or extent of interleukin-12 secretion." [GOC:obol]
-synonym: "positive regulation of CLMF secretion" RELATED [GOC:obol]
-synonym: "positive regulation of IL-12 secretion" EXACT [GOC:obol]
-synonym: "positive regulation of IL12 secretion" EXACT [GOC:obol]
-synonym: "positive regulation of interleukin-12 complex secretion" EXACT [GOC:obol]
-synonym: "positive regulation of NKSF secretion" RELATED [GOC:obol]
-is_a: GO:0032735 ! positive regulation of interleukin-12 production
-is_a: GO:0050715 ! positive regulation of cytokine secretion
-is_a: GO:2001182 ! regulation of interleukin-12 secretion
-intersection_of: GO:0008150 ! biological_process
-intersection_of: positively_regulates GO:0072610 ! interleukin-12 secretion
-relationship: positively_regulates GO:0072610 ! interleukin-12 secretion
-created_by: yaf
-creation_date: 2011-11-03T01:10:41Z
-
[Term]
id: GO:2001185
name: regulation of CD8-positive, alpha-beta T cell activation
@@ -606885,7 +603340,6 @@ synonym: "regulation of isopentenyl diphosphate synthesis, mevalonate pathway" E
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
-is_a: GO:0051196 ! regulation of coenzyme metabolic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
is_a: GO:1900542 ! regulation of purine nucleotide metabolic process
intersection_of: GO:0008150 ! biological_process
@@ -606907,7 +603361,6 @@ synonym: "negative regulation of isopentenyl diphosphate synthesis, mevalonate p
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
-is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process
is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
@@ -607127,7 +603580,6 @@ id: GO:2001227
name: quercitrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with quercitrin." [GOC:obol]
-is_a: GO:0008144 ! drug binding
is_a: GO:0043168 ! anion binding
is_a: GO:0097243 ! flavonoid binding
is_a: GO:0097367 ! carbohydrate derivative binding
@@ -608129,8 +604581,6 @@ name: codeine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [GOC:yaf]
synonym: "codeine metabolism" EXACT [GOC:obol]
-is_a: GO:0006805 ! xenobiotic metabolic process
-is_a: GO:0017144 ! drug metabolic process
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process
is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process
created_by: pr
@@ -608144,8 +604594,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of codeine,
synonym: "codeine breakdown" EXACT [GOC:obol]
synonym: "codeine catabolism" EXACT [GOC:obol]
synonym: "codeine degradation" EXACT [GOC:obol]
-is_a: GO:0042178 ! xenobiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0071274 ! isoquinoline alkaloid catabolic process
is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process
is_a: GO:2001291 ! codeine metabolic process
@@ -608384,7 +604832,6 @@ def: "The chemical reactions and pathways involving the epipolythiodioxopiperazi
synonym: "gliotoxin metabolism" EXACT [GOC:obol]
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process
-is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0043385 ! mycotoxin metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
@@ -608399,8 +604846,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of the epip
synonym: "gliotoxin breakdown" EXACT [GOC:obol]
synonym: "gliotoxin catabolism" EXACT [GOC:obol]
synonym: "gliotoxin degradation" EXACT [GOC:obol]
-is_a: GO:0017001 ! antibiotic catabolic process
-is_a: GO:0042737 ! drug catabolic process
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
@@ -608421,7 +604866,6 @@ synonym: "gliotoxin biosynthesis" EXACT [GOC:obol]
synonym: "gliotoxin formation" EXACT [GOC:obol]
synonym: "gliotoxin synthesis" EXACT [GOC:obol]
is_a: GO:0009072 ! aromatic amino acid family metabolic process
-is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
diff --git a/resources/resource_v1.0.1.txt b/resources/resource_v1.0.2.txt
similarity index 100%
rename from resources/resource_v1.0.1.txt
rename to resources/resource_v1.0.2.txt
diff --git a/resources/web/about.html b/resources/web/about.html
index ceea7f7..ce15dad 100644
--- a/resources/web/about.html
+++ b/resources/web/about.html
@@ -54,6 +54,13 @@
https://app.tappas.org/downloads
+ Or use the following text:
+
+ tappAS: a comprehensive computational framework for the analysis of the functional impact of differential splicing.
+ Lorena de la Fuente, Ángeles Arzalluz-Luque, Manuel Tardáguila, Héctor del Risco, Cristina Martí, Sonia Tarazona, Pedro Salguero, Raymond Scott, Ana Alastrue-Agudo, Pablo Bonilla, Jeremy Newman, Lauren McIntyre, Victoria Moreno-Manzano, Ana Cones.
+ Genome Biology; doi: https://doi.org/10.1186/s13059-020-02028-w
+
+
diff --git a/scripts/DFI.R b/scripts/DFI.R
index ad34b12..12537cc 100644
--- a/scripts/DFI.R
+++ b/scripts/DFI.R
@@ -113,8 +113,17 @@ DEXSeq.DS <- function(raw.counts, feature_association, factors) {
bp_param <- SnowParam(workers=4);
}
- ##CODE to prevent error (if only have one gene (with and without) doesn't work)
- if(dim(dxd)[1]<=2){return(NULL)}
+ ##CODE to prevent error (if only have one gene (with and without) does not work)
+ if((dim(dxd)[1])/2<=1){return(NULL)}
+
+ dxd <- tryCatch({estimateDispersions(dxd, BPPARAM = bp_param)}, #try
+ error=function(cond){return(NA)} # error
+ )
+
+ if(is.na(dxd)){
+ cat("It is possible you have a low number of genes/features and the method can not stimate the results.\n")
+ return(results) # low samples/genes and we can not calculate the results
+ }
dxd <- estimateDispersions(dxd, BPPARAM = bp_param);
## Run the test and get results for exon bins
@@ -467,8 +476,6 @@ for(db in dbs$db) {
### end filter
if(nrow(dbcatMatrixRaw) == 0){
- print("1ºError")
- print(nrow(dbcatMatrixRaw))
cont_err = cont_err + 1
next
}
@@ -505,6 +512,8 @@ for(db in dbs$db) {
}
### end filter
+ cat(paste0(nrow(dbcatMatrixRaw), " isoforms remain.\n"))
+
if(nrow(dbcatMatrixRaw) == 0){
cont_err = cont_err + 1
cat("For the category", as.character(category), "you have 0 transcripts to analyze.")
@@ -512,6 +521,7 @@ for(db in dbs$db) {
catResults = DEXSeq.DS(dbcatMatrixRaw, dbcatGenes, myfactors)
}
}
+
if(is.null(catResults)){
print("Your result matrix do not have results.")
len_zero = T
@@ -523,13 +533,13 @@ for(db in dbs$db) {
}
# if we dont have trans and we dont processed any feature before
-if(len_zero & cont_err == cont){
+if((len_zero & cont_err == cont) | is.null(results)){
cat("Final output\n")
if(!is.null(results))
write.table(results, file.path(outdir, paste0("dfi_result.",as.character(analysisId),".tsv")), quote=FALSE, row.names=FALSE, sep="\t")
# write completion file
- cat("You have 0 transcripts to analyze with this feature.\n")
+ cat("You have 0 transcripts to analyze with this feature/s.\n")
}else{
cat("Preliminary final output\n")
diff --git a/scripts/DFI_TimeCourse.R b/scripts/DFI_TimeCourse.R
index b9c0817..3ee1991 100644
--- a/scripts/DFI_TimeCourse.R
+++ b/scripts/DFI_TimeCourse.R
@@ -791,7 +791,7 @@ for(db in sources$db) {
}
# if we dont have trans and we dont processed any feature before
-if(len_zero & cont == 0){
+if((len_zero & cont == 0) | is.null(result_dfi)){
cat("Final output\n")
write.table(result_dfi, file.path(outdir, paste0("dfi_result.",as.character(analysisId),".tsv")), quote=FALSE, row.names=FALSE, sep="\t")
# write completion file