From 465e9ce7a358c88f4da844f6f74dba31fbb6415b Mon Sep 17 00:00:00 2001 From: psalguerog <59012739+psalguerog@users.noreply.github.com> Date: Thu, 23 Jul 2020 13:27:32 +0200 Subject: [PATCH] v.1.0.2 DFI bug fixed and miscellaneous changes. --- Tappas.java | 6 +- resources/go.obo | 11814 ++++++---------- ...esource_v1.0.1.txt => resource_v1.0.2.txt} | 0 resources/web/about.html | 7 + scripts/DFI.R | 22 +- scripts/DFI_TimeCourse.R | 2 +- 6 files changed, 4156 insertions(+), 7695 deletions(-) rename resources/{resource_v1.0.1.txt => resource_v1.0.2.txt} (100%) diff --git a/Tappas.java b/Tappas.java index a7ad567..8babb70 100644 --- a/Tappas.java +++ b/Tappas.java @@ -37,7 +37,7 @@ public class Tappas extends Application { // otherwise, it will just inform the user that the app is already running // WARNING: if the app shutdowns w/o deleting file, // it is possible that a different app is now using the port - // May want to deal with it later if we stick to this locking approach + // May want to deaTo cite us visit: l with it later if we stick to this locking approach // In unix/linux/mac, can execute script and use netstat for port and then ps to get the process // b) If file not found, will look for a port to lock and create // a lock file to save the number - when exiting, the app will delete the file @@ -51,11 +51,11 @@ public class Tappas extends Application { public static final String APP_NAME = "tappas"; public static final int APP_MAJOR_VER = 1; public static final int APP_MINOR_VER = 0; - public static final int APP_STRREV = 1; + public static final int APP_STRREV = 2; public static final String RES_VER_FILE = "resource_v" + APP_MAJOR_VER + "." + APP_MINOR_VER + "." + APP_STRREV + ".txt"; public static final String APP_LOCK_FILE = ".tappas.lock.prm"; public static final String APP_PORT_PARAM = "port"; - public static final String APP_STRVER = APP_MAJOR_VER + "." + String.format("%02d", APP_MINOR_VER) + "." + String.format("%02d", APP_STRREV); + public static final String APP_STRVER = APP_MAJOR_VER + "." + String.format("%01d", APP_MINOR_VER) + "." + String.format("%01d", APP_STRREV); public static final double APP_VER = APP_MAJOR_VER + (APP_MINOR_VER/100.0); public boolean havePackages = false; private static final App app = new App(); diff --git a/resources/go.obo b/resources/go.obo index 05f1730..fb9bb45 100644 --- a/resources/go.obo +++ b/resources/go.obo @@ -1,5 +1,6 @@ format-version: 1.2 -data-version: releases/2020-05-02 +data-version: releases/2020-07-16 +subsetdef: chebi_ph7_3 "Rhea list of ChEBI terms representing the major species at pH 7.3." subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_agr "AGR slim" @@ -588,14 +589,11 @@ is_obsolete: true id: GO:0000062 name: fatty-acyl-CoA binding namespace: molecular_function -def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732] -synonym: "acyl-CoA or acyl binding" BROAD [] -is_a: GO:0032559 ! adenyl ribonucleotide binding -is_a: GO:0033218 ! amide binding -is_a: GO:0043168 ! anion binding -is_a: GO:0050662 ! coenzyme binding +def: "Interacting selectively and non-covalently with a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732] +synonym: "fatty-acyl binding" BROAD [] +synonym: "fatty-acyl-coenzyme A binding" EXACT [] +is_a: GO:0120227 ! acyl-CoA binding is_a: GO:1901567 ! fatty acid derivative binding -is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0000064 @@ -881,7 +879,6 @@ synonym: "S-adenosylmethionine transmembrane transporter activity" EXACT [] synonym: "S-adenosylmethionine transporter activity" BROAD [] synonym: "SAM transmembrane transporter activity" EXACT [] xref: Reactome:R-HSA-8855062 "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy" -is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:1901962 ! S-adenosyl-L-methionine transmembrane transport @@ -1341,7 +1338,7 @@ synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1 synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] xref: EC:1.1.1.101 xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN -xref: Reactome:R-HSA-75883 "O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+" +xref: Reactome:R-HSA-75883 "DHRS7B reduces GO3P to HXDG3P" xref: RHEA:17341 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -1419,7 +1416,7 @@ def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylma subset: goslim_chembl synonym: "SNAP receptor binding" EXACT [] xref: Reactome:R-HSA-210426 "Glutamate synaptic vesicle docking and priming" -xref: Reactome:R-HSA-210430 "release of L-Glutamate at the synapse" +xref: Reactome:R-HSA-210430 "Release of L-Glutamate at the synapse" xref: Reactome:R-HSA-265166 "Exocytosis of Insulin" xref: Reactome:R-HSA-372505 "Acetylcholine synaptic vesicle docking and priming" xref: Reactome:R-HSA-372529 "Release of acetylcholine at the synapse" @@ -1701,9 +1698,9 @@ def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' ter synonym: "3'-5' exoribonuclease activity" EXACT [] xref: EC:3.1.13 xref: Reactome:R-HSA-430028 "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion" -xref: Reactome:R-HSA-6791218 "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA" xref: Reactome:R-HSA-6791222 "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA" xref: Reactome:R-HSA-6791227 "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA" +xref: Reactome:R-HSA-9682603 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters @@ -2178,6 +2175,7 @@ synonym: "Tpt1p" RELATED [EC:2.7.1.160] synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] xref: EC:2.7.1.160 xref: MetaCyc:2.7.1.160-RXN +xref: RHEA:23324 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -2664,7 +2662,6 @@ name: allantoin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684] synonym: "allantoin metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -2679,7 +2676,6 @@ synonym: "allantoin breakdown" EXACT [] synonym: "allantoin catabolism" EXACT [] synonym: "allantoin degradation" EXACT [] is_a: GO:0000255 ! allantoin metabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -2920,6 +2916,7 @@ synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase ac synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59] xref: EC:2.1.1.59 xref: MetaCyc:2.1.1.59-RXN +xref: RHEA:24312 is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] @@ -3145,7 +3142,6 @@ namespace: biological_process def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] is_a: GO:0006812 ! cation transport is_a: GO:0015846 ! polyamine transport -is_a: GO:0015893 ! drug transport [Term] id: GO:0000297 @@ -3168,6 +3164,7 @@ synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10] xref: EC:3.6.1.10 xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN +xref: RHEA:22452 is_a: GO:0016462 ! pyrophosphatase activity [Term] @@ -3225,9 +3222,7 @@ name: response to singlet oxygen namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732] is_a: GO:0000302 ! response to reactive oxygen species -is_a: GO:0007584 ! response to nutrient is_a: GO:0010035 ! response to inorganic substance -is_a: GO:0042493 ! response to drug [Term] id: GO:0000305 @@ -3488,7 +3483,7 @@ relationship: part_of GO:0062159 ! contractile vacuole complex id: GO:0000332 name: template for synthesis of G-rich strand of telomere DNA activity namespace: molecular_function -def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242] +def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242, PMID:7958872] comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins. synonym: "telomerase RNA" EXACT [] synonym: "telomerase, template" EXACT [] @@ -4891,6 +4886,7 @@ def: "Interacting selectively and non-covalently with nucleic acid via hydrogen comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. synonym: "base pairing with DNA" RELATED [] is_a: GO:0003677 ! DNA binding +is_a: GO:0140489 ! molecular template activity [Term] id: GO:0000500 @@ -5726,6 +5722,7 @@ synonym: "PLMT" EXACT [] synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71] xref: EC:2.1.1.71 xref: MetaCyc:2.1.1.71-RXN +xref: RHEA:32735 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity @@ -6119,6 +6116,7 @@ synonym: "DGPP phosphohydrolase activity" EXACT [] synonym: "diacylglycerol pyrophosphate phosphatase activity" EXACT [] xref: EC:3.1.3.81 xref: MetaCyc:RXN-11277 +xref: RHEA:27449 is_a: GO:0016462 ! pyrophosphatase activity [Term] @@ -6227,7 +6225,6 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators] synonym: "InsP6 binding" EXACT [] synonym: "IP6 binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding is_a: GO:0043178 ! alcohol binding @@ -6256,6 +6253,7 @@ synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] xref: Reactome:R-HSA-1855185 "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus" +xref: RHEA:11856 is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] @@ -6285,7 +6283,7 @@ id: GO:0000827 name: inositol-1,3,4,5,6-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown." [GOC:elh, PMID:11311242] -synonym: "EC:2.7.4.21" BROAD [] +xref: EC:2.7.4.21 xref: Reactome:R-HSA-1855181 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus" xref: Reactome:R-HSA-1855223 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol" is_a: GO:0016301 ! kinase activity @@ -6475,6 +6473,7 @@ def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino- synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] xref: EC:2.5.1.78 xref: MetaCyc:LUMAZINESYN-RXN +xref: RHEA:26152 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] @@ -6776,13 +6775,17 @@ is_a: GO:0030428 ! cell septum id: GO:0000935 name: division septum namespace: cellular_component +alt_id: GO:0043187 def: "A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt, GOC:vw] +synonym: "cell septum surface" RELATED [] synonym: "complete septum" EXACT [] synonym: "divison septum" EXACT [] +synonym: "septum surface" BROAD [] is_a: GO:0030428 ! cell septum intersection_of: GO:0030428 ! cell septum intersection_of: part_of GO:0032153 ! cell division site relationship: part_of GO:0032153 ! cell division site +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19434 xsd:anyURI [Term] id: GO:0000936 @@ -6932,7 +6935,6 @@ def: "The chemical reactions and pathways involving the catabolism of amino acid is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0009087 ! methionine catabolic process -is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] @@ -7200,7 +7202,7 @@ alt_id: GO:0001201 alt_id: GO:0001202 alt_id: GO:0001203 alt_id: GO:0003705 -def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] +def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] @@ -9108,7 +9110,7 @@ name: DNA-binding transcription activator activity namespace: molecular_function alt_id: GO:0001140 alt_id: GO:0001215 -def: "Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase." [GOC:krc] +def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase." [GOC:txnOH-2018] synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" RELATED [] synonym: "bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding" NARROW [] @@ -9131,7 +9133,7 @@ alt_id: GO:0001141 alt_id: GO:0001218 alt_id: GO:0001219 alt_id: GO:0001220 -def: "Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase." [GOC:krc] +def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase." [GOC:txnOH-2018] synonym: "bacterial-type DNA binding transcription repressor activity" NARROW [] synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding" NARROW [] @@ -9214,7 +9216,7 @@ alt_id: GO:0001078 alt_id: GO:0001206 alt_id: GO:0001210 alt_id: GO:0001214 -def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] +def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] synonym: "distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW [] synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] @@ -9248,7 +9250,7 @@ alt_id: GO:0001209 alt_id: GO:0001211 alt_id: GO:0001212 alt_id: GO:0001213 -def: "A protein, or a member of a complex, or a non-coding RNA that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] +def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW [] synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] @@ -9805,8 +9807,6 @@ synonym: "phaseolin activity" RELATED [EC:3.4.22.34] synonym: "proteinase B" RELATED [EC:3.4.22.34] synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34] synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34] -xref: EC:3.4.22.34 -xref: MetaCyc:3.4.22.34-RXN is_obsolete: true replaced_by: GO:0004197 @@ -9848,6 +9848,7 @@ synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [] xref: EC:1.10.99.2 xref: MetaCyc:1.10.99.2-RXN xref: Reactome:R-HSA-8936519 "NQO2:FAD dimer reduces quinones to hydroquinones" +xref: RHEA:12364 is_a: GO:0016491 ! oxidoreductase activity [Term] @@ -11189,6 +11190,7 @@ xref: EC:2.4.99.3 xref: MetaCyc:2.4.99.3-RXN xref: Reactome:R-HSA-4084980 "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)" xref: Reactome:R-HSA-9603991 "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG" +xref: RHEA:11136 is_a: GO:0008373 ! sialyltransferase activity [Term] @@ -11455,7 +11457,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process -is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process is_a: GO:0097164 ! ammonium ion metabolic process @@ -11472,7 +11473,6 @@ synonym: "histamine synthesis" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process -is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process @@ -11745,6 +11745,7 @@ def: "Projection at the leading edge of a crawling cell; the protrusions are sup synonym: "membrane ruffle" RELATED [] is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0031252 ! cell leading edge +property_value: RO:0002161 NCBITaxon:4890 [Term] id: GO:0001727 @@ -11782,6 +11783,7 @@ xref: MetaCyc:RXN-13648 xref: Reactome:R-HSA-8983680 "OAS1 produces oligoadenylates" xref: Reactome:R-HSA-8985091 "OAS3 produces oligoadenylates" xref: Reactome:R-HSA-8985104 "OAS2 produces oligoadenylates" +xref: RHEA:34407 is_a: GO:0070566 ! adenylyltransferase activity [Term] @@ -12076,7 +12078,6 @@ name: beta-alanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd] synonym: "beta-alanine transporter activity" BROAD [] -is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity relationship: part_of GO:0001762 ! beta-alanine transport @@ -12085,7 +12086,6 @@ id: GO:0001762 name: beta-alanine transport namespace: biological_process def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd] -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015804 ! neutral amino acid transport [Term] @@ -13537,7 +13537,7 @@ name: regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001897 ! cytolysis by symbiont of host cells @@ -14116,7 +14116,7 @@ namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" RELATED [] is_a: GO:0048731 ! system development -relationship: part_of GO:0072358 ! cardiovascular system development +relationship: part_of GO:0072359 ! circulatory system development [Term] id: GO:0001945 @@ -14470,10 +14470,7 @@ id: GO:0001975 name: response to amphetamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:dph, GOC:ef] -is_a: GO:0009410 ! response to xenobiotic stimulus -is_a: GO:0009636 ! response to toxic substance is_a: GO:0014075 ! response to amine -is_a: GO:0097366 ! response to bronchodilator [Term] id: GO:0001976 @@ -15098,8 +15095,6 @@ synonym: "regulation of L-glutamate import" BROAD [] synonym: "regulation of L-glutamate transport" BROAD [] synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane -is_a: GO:0051580 ! regulation of neurotransmitter uptake -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098712 ! L-glutamate import across plasma membrane relationship: regulates GO:0098712 ! L-glutamate import across plasma membrane @@ -15129,10 +15124,8 @@ synonym: "negative regulation of L-glutamate transport" BROAD [] synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "regulation of L-glutamate import" BROAD [] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane -is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane relationship: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane @@ -15162,10 +15155,8 @@ synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "upregulation of L-glutamate transport" BROAD [] synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane -is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane relationship: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane @@ -15363,7 +15354,6 @@ name: uracil binding namespace: molecular_function def: "Interacting selectively and non-covalently with uracil." [GOC:hjd] is_a: GO:0002061 ! pyrimidine nucleobase binding -is_a: GO:0008144 ! drug binding [Term] id: GO:0002059 @@ -15570,6 +15560,7 @@ def: "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxyben xref: EC:2.5.1.39 xref: MetaCyc:RXN-9230 xref: Reactome:R-HSA-2162192 "PHB and all-E-10PrP2 are combined into DHB by COQ2" +xref: RHEA:44564 is_a: GO:0002094 ! polyprenyltransferase activity [Term] @@ -16125,6 +16116,7 @@ def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyro synonym: "HMP-PP diphosphatase" EXACT [] synonym: "HMP-PP pyrophosphatase" EXACT [] xref: MetaCyc:RXN0-3543 +xref: RHEA:27914 is_a: GO:0016462 ! pyrophosphatase activity created_by: hjd creation_date: 2009-06-10T11:21:35Z @@ -18691,7 +18683,6 @@ namespace: biological_process def: "The regulated release of platelet activating factor by a cell." [GOC:add, ISBN:0781735149] is_a: GO:0010876 ! lipid localization is_a: GO:0015697 ! quaternary ammonium group transport -is_a: GO:0015893 ! drug transport is_a: GO:0015914 ! phospholipid transport is_a: GO:0050663 ! cytokine secretion is_a: GO:0140353 ! lipid export from cell @@ -20193,7 +20184,7 @@ namespace: biological_process def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] synonym: "serotonin release by mast cell" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response -is_a: GO:0046907 ! intracellular transport +is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0140029 ! exocytic process relationship: part_of GO:0043303 ! mast cell degranulation @@ -20203,7 +20194,7 @@ name: histamine secretion by mast cell namespace: biological_process def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] is_a: GO:0002441 ! histamine secretion involved in inflammatory response -is_a: GO:0046907 ! intracellular transport +is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0140029 ! exocytic process relationship: part_of GO:0043303 ! mast cell degranulation @@ -22514,8 +22505,12 @@ relationship: positively_regulates GO:0002228 ! natural killer cell mediated imm id: GO:0002718 name: regulation of cytokine production involved in immune response namespace: biological_process +alt_id: GO:0002739 +alt_id: GO:0002742 def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] +synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] +synonym: "regulation of cytokine secretion involved in immune response" NARROW [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0050776 ! regulation of immune response @@ -22527,12 +22522,16 @@ relationship: regulates GO:0002367 ! cytokine production involved in immune resp id: GO:0002719 name: negative regulation of cytokine production involved in immune response namespace: biological_process +alt_id: GO:0002740 +alt_id: GO:0002743 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine production during immune response" RELATED [] synonym: "down-regulation of cytokine production during immune response" EXACT [] synonym: "downregulation of cytokine production during immune response" RELATED [] synonym: "inhibition of cytokine production during immune response" RELATED [] +synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] +synonym: "negative regulation of cytokine secretion involved in immune response" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response @@ -22545,9 +22544,13 @@ relationship: negatively_regulates GO:0002367 ! cytokine production involved in id: GO:0002720 name: positive regulation of cytokine production involved in immune response namespace: biological_process +alt_id: GO:0002741 +alt_id: GO:0002744 def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "activation of cytokine production during immune response" NARROW [] +synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW [] synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] +synonym: "positive regulation of cytokine secretion involved in immune response" NARROW [] synonym: "stimulation of cytokine production during immune response" NARROW [] synonym: "up regulation of cytokine production during immune response" RELATED [] synonym: "up-regulation of cytokine production during immune response" RELATED [] @@ -22843,100 +22846,6 @@ intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production -[Term] -id: GO:0002739 -name: regulation of cytokine secretion involved in immune response -namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] -synonym: "regulation of cytokine secretion during immune response" RELATED [GOC:dph] -is_a: GO:0002718 ! regulation of cytokine production involved in immune response -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0002374 ! cytokine secretion involved in immune response -relationship: regulates GO:0002374 ! cytokine secretion involved in immune response - -[Term] -id: GO:0002740 -name: negative regulation of cytokine secretion involved in immune response -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] -synonym: "down regulation of cytokine secretion during immune response" RELATED [] -synonym: "down-regulation of cytokine secretion during immune response" RELATED [] -synonym: "downregulation of cytokine secretion during immune response" RELATED [] -synonym: "inhibition of cytokine secretion during immune response" NARROW [] -synonym: "negative regulation of cytokine secretion during immune response" RELATED [GOC:dph] -is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response -is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response -is_a: GO:0050710 ! negative regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response -relationship: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response - -[Term] -id: GO:0002741 -name: positive regulation of cytokine secretion involved in immune response -namespace: biological_process -def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] -synonym: "activation of cytokine secretion during immune response" NARROW [] -synonym: "positive regulation of cytokine secretion during immune response" RELATED [GOC:dph] -synonym: "stimulation of cytokine secretion during immune response" NARROW [] -synonym: "up regulation of cytokine secretion during immune response" RELATED [] -synonym: "up-regulation of cytokine secretion during immune response" RELATED [] -synonym: "upregulation of cytokine secretion during immune response" RELATED [] -is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response -is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response -is_a: GO:0050715 ! positive regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0002374 ! cytokine secretion involved in immune response -relationship: positively_regulates GO:0002374 ! cytokine secretion involved in immune response - -[Term] -id: GO:0002742 -name: regulation of cytokine biosynthetic process involved in immune response -namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add] -synonym: "regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] -is_a: GO:0002718 ! regulation of cytokine production involved in immune response -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response -relationship: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response - -[Term] -id: GO:0002743 -name: negative regulation of cytokine biosynthetic process involved in immune response -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] -synonym: "down regulation of cytokine biosynthetic process during immune response" RELATED [] -synonym: "down-regulation of cytokine biosynthetic process during immune response" RELATED [] -synonym: "downregulation of cytokine biosynthetic process during immune response" RELATED [] -synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW [] -synonym: "negative regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] -is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response -is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response -relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response - -[Term] -id: GO:0002744 -name: positive regulation of cytokine biosynthetic process involved in immune response -namespace: biological_process -def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] -synonym: "activation of cytokine biosynthetic process during immune response" NARROW [] -synonym: "positive regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] -synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW [] -synonym: "up regulation of cytokine biosynthetic process during immune response" RELATED [] -synonym: "up-regulation of cytokine biosynthetic process during immune response" RELATED [] -synonym: "upregulation of cytokine biosynthetic process during immune response" RELATED [] -is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response -is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response -relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response - [Term] id: GO:0002745 name: antigen processing and presentation initiated by receptor mediated uptake of antigen @@ -25491,7 +25400,6 @@ id: GO:0002936 name: bradykinin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin." [PMID:11226291] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0043043 ! peptide biosynthetic process created_by: hjd creation_date: 2012-10-17T14:24:24Z @@ -25611,6 +25519,7 @@ def: "Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA synonym: "ArcS" RELATED [] synonym: "glutamine:preQ0-tRNA amidinotransferase" RELATED [] xref: EC:2.6.1.97 +xref: RHEA:54084 is_a: GO:0015067 ! amidinotransferase activity created_by: hjd creation_date: 2014-08-11T10:33:59Z @@ -26164,14 +26073,15 @@ is_a: GO:0003053 ! circadian regulation of heart rate [Term] id: GO:0003056 -name: regulation of vascular smooth muscle contraction +name: regulation of vascular associated smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl] +synonym: "regulation of vascular smooth muscle contraction" EXACT [] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0019229 ! regulation of vasoconstriction intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0014829 ! vascular smooth muscle contraction -relationship: regulates GO:0014829 ! vascular smooth muscle contraction +intersection_of: regulates GO:0014829 ! vascular associated smooth muscle contraction +relationship: regulates GO:0014829 ! vascular associated smooth muscle contraction [Term] id: GO:0003057 @@ -30375,6 +30285,7 @@ alt_id: GO:0004003 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.4.12, GOC:jl] synonym: "ATP-dependent DNA helicase activity" EXACT [] xref: EC:3.6.4.12 +xref: Reactome:R-HSA-5693589 "D-loop dissociation and strand annealing" is_a: GO:0004386 ! helicase activity is_a: GO:0008094 ! DNA-dependent ATPase activity is_a: GO:0140097 ! catalytic activity, acting on DNA @@ -30382,11 +30293,14 @@ relationship: part_of GO:0032508 ! DNA duplex unwinding [Term] id: GO:0003680 -name: AT DNA binding +name: minor groove of adenine-thymine-rich DNA binding namespace: molecular_function -def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564] +def: "Interacting selectively and non-covalently with the structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins." [GOC:jl, PMID:10545119, PMID:15802641, PMID:26223912, PMID:2670564] synonym: "AT binding" EXACT [] -is_a: GO:1990837 ! sequence-specific double-stranded DNA binding +synonym: "AT DNA binding" EXACT [] +synonym: "AT-rich DNA binding" EXACT [] +is_a: GO:0000217 ! DNA secondary structure binding +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19695 xsd:anyURI [Term] id: GO:0003681 @@ -30476,6 +30390,7 @@ def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the openi synonym: "DNA clamp loading ATPase activity" EXACT [] synonym: "PCNA loading activity" NARROW [] synonym: "PCNA loading complex activity" NARROW [] +xref: Reactome:R-HSA-174439 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:R-HSA-176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" is_a: GO:0003677 ! DNA binding is_a: GO:0033170 ! protein-DNA loading ATPase activity @@ -30563,7 +30478,7 @@ alt_id: GO:0001131 alt_id: GO:0001151 alt_id: GO:0001199 alt_id: GO:0001204 -def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] +def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] comment: Curator guidance: Note that most DNA-binding transcription factors do not have enzymatic activity. The presence of specific domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing Myb/SANT and ARID domains, since only a subset of proteins containing these domains are DNA-binding transcription factors for specific genes. subset: goslim_agr subset: goslim_aspergillus @@ -31040,6 +30955,7 @@ xref: EC:5.2.1.8 xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN xref: Reactome:R-HSA-2022073 "Procollagen triple helix formation" xref: Reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1" +xref: RHEA:16237 is_a: GO:0016859 ! cis-trans isomerase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0000413 ! protein peptidyl-prolyl isomerization @@ -31460,8 +31376,6 @@ synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21] synonym: "blood coagulation factor VII activity" EXACT [] synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21] synonym: "coagulation factor VIIa activity" EXACT [] -xref: EC:3.4.21.21 -xref: MetaCyc:3.4.21.21-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31480,8 +31394,6 @@ synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22] synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22] synonym: "Christmas factor activity" EXACT [EC:3.4.21.22] synonym: "coagulation factor IXa activity" EXACT [] -xref: EC:3.4.21.22 -xref: MetaCyc:3.4.21.22-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31505,8 +31417,6 @@ synonym: "Stuart factor" RELATED [EC:3.4.21.6] synonym: "Stuart factor activity" EXACT [EC:3.4.21.6] synonym: "thrombokinase activity" EXACT [EC:3.4.21.6] synonym: "thromboplastin" RELATED [EC:3.4.21.6] -xref: EC:3.4.21.6 -xref: MetaCyc:3.4.21.6-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31522,8 +31432,6 @@ synonym: "blood coagulation factor XI activity" EXACT [] synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27] synonym: "coagulation factor XIa activity" EXACT [] synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27] -xref: EC:3.4.21.27 -xref: MetaCyc:3.4.21.27-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31545,8 +31453,6 @@ synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38] synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38] synonym: "prealbumin activator" RELATED [EC:3.4.21.38] synonym: "prekallikrein activator" RELATED [EC:3.4.21.38] -xref: EC:3.4.21.38 -xref: MetaCyc:3.4.21.38-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31575,8 +31481,6 @@ synonym: "plasma kallikrein activity" EXACT [] synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34] synonym: "urinary kallikrein" RELATED [EC:3.4.21.34] synonym: "urokallikrein" RELATED [EC:3.4.21.34] -xref: EC:3.4.21.34 -xref: MetaCyc:3.4.21.34-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31594,8 +31498,6 @@ synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69] synonym: "GSAPC" RELATED [EC:3.4.21.69] synonym: "protein C (activated) activity" EXACT [] synonym: "protein Ca" RELATED [EC:3.4.21.69] -xref: EC:3.4.21.69 -xref: MetaCyc:3.4.21.69-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31618,8 +31520,6 @@ synonym: "thrombin-C" RELATED [EC:3.4.21.5] synonym: "thrombofort" RELATED [EC:3.4.21.5] synonym: "topical" RELATED [EC:3.4.21.5] synonym: "tropostasin" RELATED [EC:3.4.21.5] -xref: EC:3.4.21.5 -xref: MetaCyc:3.4.21.5-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31643,6 +31543,7 @@ xref: MetaCyc:2.3.2.13-RXN xref: Reactome:R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+" xref: Reactome:R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking" xref: RESID:AA0124 +xref: RHEA:54816 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] @@ -31678,8 +31579,6 @@ synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47] synonym: "heat-labile factor" RELATED [EC:3.4.21.47] synonym: "proenzyme factor B" EXACT [] synonym: "properdin factor B activity" EXACT [EC:3.4.21.47] -xref: EC:3.4.21.47 -xref: MetaCyc:3.4.21.47-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31699,8 +31598,6 @@ synonym: "classical-complement-pathway C3/C5 convertase activity" EXACT [] synonym: "complement C2 activity" BROAD [EC:3.4.21.43] synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43] synonym: "complement C42" RELATED [EC:3.4.21.43] -xref: EC:3.4.21.43 -xref: MetaCyc:3.4.21.43-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31714,8 +31611,6 @@ synonym: "activated complement C1r" RELATED [EC:3.4.21.41] synonym: "C1r esterase activity" EXACT [EC:3.4.21.41] synonym: "complement component C1r activity" EXACT [] synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41] -xref: EC:3.4.21.41 -xref: MetaCyc:3.4.21.41-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31731,8 +31626,6 @@ synonym: "C1s esterase activity" EXACT [EC:3.4.21.42] synonym: "complement C1s" RELATED [EC:3.4.21.42] synonym: "complement component C1s activity" EXACT [] synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42] -xref: EC:3.4.21.42 -xref: MetaCyc:3.4.21.42-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31749,8 +31642,6 @@ synonym: "complement factor D activity" EXACT [] synonym: "factor D" RELATED [EC:3.4.21.46] synonym: "factor D (complement)" RELATED [EC:3.4.21.46] synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46] -xref: EC:3.4.21.46 -xref: MetaCyc:3.4.21.46-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31771,8 +31662,6 @@ synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45] synonym: "complement factor I activity" EXACT [] synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45] synonym: "factor I" RELATED [EC:3.4.21.45] -xref: EC:3.4.21.45 -xref: MetaCyc:3.4.21.45-RXN is_obsolete: true replaced_by: GO:0004252 @@ -31963,6 +31852,7 @@ synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosamin xref: EC:2.4.1.144 xref: MetaCyc:2.4.1.144-RXN xref: Reactome:R-HSA-975926 "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3" +xref: RHEA:15509 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein @@ -32121,6 +32011,7 @@ xref: EC:4.3.2.9 xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN xref: Reactome:R-HSA-1247922 "GGCT transforms gGluCys to OPRO" xref: Reactome:R-HSA-6785928 "CHAC1,2 cleaves GSH to OPRO and CysGly" +xref: RHEA:20505 is_a: GO:0016842 ! amidine-lyase activity [Term] @@ -32222,6 +32113,7 @@ synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EX synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] xref: EC:2.4.1.34 xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN +xref: RHEA:21476 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -32460,6 +32352,7 @@ xref: Reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized xref: Reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one" xref: Reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione" xref: Reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol" +xref: RHEA:24076 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -32588,6 +32481,7 @@ synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33] synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] xref: EC:4.2.1.33 xref: MetaCyc:3-ISOPROPYLMALISOM-RXN +xref: RHEA:32287 is_a: GO:0016836 ! hydro-lyase activity [Term] @@ -32638,6 +32532,7 @@ synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4] synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4] xref: EC:1.2.4.4 xref: MetaCyc:1.2.4.4-RXN +xref: RHEA:13457 is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] @@ -32721,7 +32616,7 @@ synonym: "gamma-aminobutyric acid transaminase activity" EXACT [] synonym: "gamma-aminobutyric transaminase activity" EXACT [] synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [] xref: MetaCyc:GABATRANSAM-RXN -xref: Reactome:R-HSA-916855 "Conversion of GABA to Succinate Semialdehyde" +xref: Reactome:R-HSA-916855 "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA" xref: RHEA:23352 is_a: GO:0008483 ! transaminase activity @@ -33100,6 +32995,7 @@ synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARR synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37] xref: EC:2.1.1.37 xref: MetaCyc:2.1.1.73-RXN +xref: RHEA:13681 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity relationship: part_of GO:0090116 ! C-5 methylation of cytosine @@ -33253,6 +33149,7 @@ xref: Reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent tran xref: Reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition" xref: Reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript" xref: Reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition" +xref: Reactome:R-HSA-9670149 "TERRA transcription" is_a: GO:0034062 ! 5'-3' RNA polymerase activity relationship: part_of GO:0032774 ! RNA biosynthetic process @@ -33361,6 +33258,7 @@ synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD [] xref: EC:2.1.1.63 xref: MetaCyc:2.1.1.63-RXN xref: Reactome:R-HSA-73892 "MGMT/hAGT mediated DNA Damage Reversal" +xref: RHEA:24000 is_a: GO:0008172 ! S-methyltransferase activity [Term] @@ -33615,8 +33513,7 @@ name: GPI-anchor transamidase activity namespace: molecular_function def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309] xref: Reactome:R-HSA-162836 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide" -is_a: GO:0016787 ! hydrolase activity -is_a: GO:0140096 ! catalytic activity, acting on a protein +is_a: GO:0004197 ! cysteine-type endopeptidase activity [Term] id: GO:0003924 @@ -33681,7 +33578,7 @@ xref: Reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4" xref: Reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP" xref: Reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity" xref: Reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments" -xref: Reactome:R-HSA-5672017 "Rheb in the mTORC1 complex hydrolyses GTP" +xref: Reactome:R-HSA-5672017 "Rheb in the MTORC1 complex hydrolyses GTP" xref: Reactome:R-HSA-5694527 "Loss of SAR1B GTPase" xref: Reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity" xref: Reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP" @@ -33698,6 +33595,9 @@ xref: Reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity" xref: Reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated" xref: Reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated" xref: Reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated" +xref: Reactome:R-HSA-9640195 "RRAGA,B hydrolyzes GTP" +xref: Reactome:R-HSA-9645598 "RRAGC,D hydrolyzes GTP" +xref: Reactome:R-HSA-9649736 "RAS intrinsic GTPase activity hydrolyzes GTP to GDP" xref: Reactome:R-HSA-983422 "Disassembly of COPII coated vesicle" xref: RHEA:19669 is_a: GO:0017111 ! nucleoside-triphosphatase activity @@ -33928,6 +33828,7 @@ synonym: "L-hydroxyaminoacid dehydratase activity" BROAD [] synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17] synonym: "L-serine deaminase activity" EXACT [] synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17] +synonym: "L-serine dehydration activity" RELATED [] synonym: "L-serine hydro-lyase (deaminating) activity" EXACT [] synonym: "serine deaminase activity" BROAD [EC:4.3.1.17] xref: EC:4.3.1.17 @@ -33985,6 +33886,7 @@ synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45] synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45] xref: EC:3.1.4.45 xref: MetaCyc:3.1.4.45-RXN +xref: RHEA:24372 is_a: GO:0015929 ! hexosaminidase activity [Term] @@ -34108,6 +34010,7 @@ xref: Reactome:R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylat xref: Reactome:R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD" xref: Reactome:R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)" xref: Reactome:R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN" +xref: Reactome:R-HSA-9686061 "Nucleoprotein is ADP-ribosylated" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] @@ -34203,7 +34106,7 @@ synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2] synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "menadione reductase activity" NARROW [EC:1.6.5.2] -synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] +synonym: "NAD(P)H dehydrogenase activity" BROAD [] synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2] @@ -34214,11 +34117,11 @@ synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2] -synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2] -synonym: "NQO1" RELATED [EC:1.6.5.2] +synonym: "naphthoquinone reductase activity" NARROW [] +synonym: "NQO1" RELATED [] synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2] -synonym: "QR1" RELATED [EC:1.6.5.2] +synonym: "QR1" RELATED [] synonym: "quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2] @@ -34227,6 +34130,7 @@ synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2] xref: EC:1.6.5.2 xref: MetaCyc:NQOR-RXN +xref: RHEA:46164 xref: UM-BBD_reactionID:r0227 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor @@ -34316,6 +34220,7 @@ synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4] xref: EC:1.6.2.4 xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN xref: Reactome:R-HSA-76494 "POR reduces CYP450:Fe3+ to CYP450:Fe2+" +xref: RHEA:24040 is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] @@ -34360,6 +34265,7 @@ synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5] xref: EC:1.6.5.5 xref: MetaCyc:QOR-RXN xref: Reactome:R-HSA-6799722 "TP53I3 oxidoreductase generates unstable semiquinones" +xref: RHEA:14269 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] @@ -34421,6 +34327,7 @@ synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4] xref: EC:6.5.1.4 xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN +xref: RHEA:23976 is_a: GO:0009975 ! cyclase activity is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds is_a: GO:0140098 ! catalytic activity, acting on RNA @@ -34502,6 +34409,13 @@ xref: Reactome:R-HSA-192624 "cRNA Extension" xref: Reactome:R-HSA-192832 "Initiation of cRNA Synthesis" xref: Reactome:R-HSA-192851 "vRNA Extension" xref: Reactome:R-HSA-192916 "Initiation of vRNA Synthesis" +xref: Reactome:R-HSA-9681651 "nsp8 generates RNA primers" +xref: Reactome:R-HSA-9681674 "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement" +xref: Reactome:R-HSA-9681840 "RTC synthesizes SARS-CoV-1 plus strand genomic RNA" +xref: Reactome:R-HSA-9682465 "RTC completes synthesis of the minus strand genomic RNA complement" +xref: Reactome:R-HSA-9682563 "nsp12 misincorporates a nucleotide in nascent RNA minus strand" +xref: Reactome:R-HSA-9685639 "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching" +xref: Reactome:R-HSA-9685681 "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs" is_a: GO:0034062 ! 5'-3' RNA polymerase activity relationship: part_of GO:0001172 ! transcription, RNA-templated @@ -34542,6 +34456,7 @@ synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15] xref: EC:1.1.3.15 xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN +xref: RHEA:16789 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] @@ -34599,6 +34514,7 @@ synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotra synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] xref: EC:2.7.8.17 xref: MetaCyc:2.7.8.17-RXN +xref: RHEA:13581 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] @@ -34795,30 +34711,30 @@ name: acetyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] synonym: "2-keto-acyl thiolase activity" EXACT [] -synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16] +synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [] synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16] -synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] -synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16] +synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [] +synonym: "3-ketoacyl thiolase activity" EXACT [] synonym: "3-ketoacyl-CoA thiolase activity" EXACT [] -synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16] -synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] -synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] -synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] -synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16] -synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] +synonym: "3-ketothiolase activity" EXACT [] +synonym: "3-oxoacyl-CoA thiolase activity" EXACT [] +synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [] +synonym: "6-oxoacyl-CoA thiolase activity" EXACT [] +synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [] +synonym: "acetyl-CoA acyltransferase activity" EXACT [] synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16] -synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] -synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] -synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] -synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16] -synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16] -synonym: "KAT" RELATED [EC:2.3.1.16] -synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] -synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] -synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] -synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] -synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] -synonym: "thiolase I" RELATED [EC:2.3.1.16] +synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [] +synonym: "beta-ketoacyl-CoA thiolase activity" NARROW [] +synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [] +synonym: "beta-ketoadipyl-CoA thiolase activity" NARROW [] +synonym: "beta-ketothiolase activity" EXACT [] +synonym: "KAT" RELATED [] +synonym: "ketoacyl-CoA acyltransferase activity" EXACT [] +synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [] +synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [] +synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [] +synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [] +synonym: "thiolase I" RELATED [] xref: EC:2.3.1.16 xref: MetaCyc:KETOACYLCOATHIOL-RXN xref: Reactome:R-HSA-390250 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA" @@ -35008,6 +34924,7 @@ xref: Reactome:R-HSA-192335 "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,1 xref: Reactome:R-HSA-193369 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA" xref: Reactome:R-HSA-2066787 "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA" xref: Reactome:R-HSA-390256 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2" +xref: RHEA:38959 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] @@ -35303,10 +35220,10 @@ synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2] xref: EC:2.6.1.2 xref: KEGG_REACTION:R00258 xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN -xref: Reactome:R-HSA-507749 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2]" -xref: Reactome:R-HSA-507775 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2]" -xref: Reactome:R-HSA-70523 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT]" -xref: Reactome:R-HSA-70524 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT]" +xref: Reactome:R-HSA-507749 "PXLP-K341-GPT2 transaminates PYR to form L-Ala" +xref: Reactome:R-HSA-507775 "PXLP-K341-GPT2 transaminates L-Ala to form PYR" +xref: Reactome:R-HSA-70523 "PXLP-K314-GPT transaminates L-Ala to form PYR" +xref: Reactome:R-HSA-70524 "PXLP-K314-GPT transaminates PYR to form L-Ala" xref: RHEA:19453 is_a: GO:0047635 ! alanine-oxo-acid transaminase activity @@ -35331,6 +35248,7 @@ synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] xref: EC:1.1.1.1 xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN xref: Reactome:R-HSA-2162078 "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+" +xref: RHEA:10740 xref: UM-BBD_enzymeID:e0023 is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity @@ -35366,6 +35284,7 @@ synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84] synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84] xref: EC:2.3.1.84 xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN +xref: RHEA:17229 is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity @@ -35396,6 +35315,7 @@ xref: EC:2.8.2.2 xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-176494 "SULTs transfer (SO4)2- group to 27HCHOL" xref: Reactome:R-HSA-176609 "cholesterol + PAPS => cholesterol sulfate + PAP" +xref: RHEA:22552 is_a: GO:0008146 ! sulfotransferase activity [Term] @@ -35477,6 +35397,7 @@ xref: KEGG_REACTION:R02820 xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN xref: Reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol" xref: Reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol" +xref: RHEA:12789 is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] @@ -35500,7 +35421,7 @@ xref: Reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is re xref: Reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one" xref: Reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one" xref: Reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol" -xref: Reactome:R-HSA-198845 "CYB5A:heme reduces SDA to VitC" +xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-" xref: Reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL" xref: Reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH" xref: Reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione" @@ -35591,6 +35512,7 @@ synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4] synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4] xref: EC:3.5.1.4 xref: MetaCyc:AMIDASE-RXN +xref: RHEA:12020 xref: UM-BBD_enzymeID:e0068 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides @@ -35630,6 +35552,7 @@ synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleot xref: EC:1.2.1.31 xref: MetaCyc:1.2.1.31-RXN xref: Reactome:R-HSA-70941 "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+" +xref: RHEA:12308 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -35672,6 +35595,7 @@ synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1 synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29] xref: EC:3.1.1.29 xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN +xref: RHEA:54448 is_a: GO:0052689 ! carboxylic ester hydrolase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -35917,6 +35841,7 @@ synonym: "arginyl-tRNA-protein transferase activity" EXACT [] synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8] xref: EC:2.3.2.8 xref: MetaCyc:ARGINYLTRANSFERASE-RXN +xref: RHEA:10208 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups relationship: part_of GO:0016598 ! protein arginylation @@ -35955,6 +35880,7 @@ synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87] xref: EC:2.3.1.87 xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-209792 "N-acetylation of serotonin" +xref: RHEA:20497 is_a: GO:0008080 ! N-acetyltransferase activity [Term] @@ -35975,6 +35901,7 @@ xref: EC:2.3.1.5 xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:R-HSA-174963 "NAT1 acetylation" xref: Reactome:R-HSA-174967 "NAT2 acetylation" +xref: RHEA:16613 xref: UM-BBD_enzymeID:e0341 is_a: GO:0008080 ! N-acetyltransferase activity @@ -36024,6 +35951,7 @@ xref: Reactome:R-HSA-159358 "SULT1A3,4 dimers sulfate DA to DAOS" xref: Reactome:R-HSA-176474 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP" xref: Reactome:R-HSA-176585 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP" xref: Reactome:R-HSA-176646 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP" +xref: RHEA:12164 is_a: GO:0008146 ! sulfotransferase activity [Term] @@ -36033,21 +35961,22 @@ namespace: molecular_function def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1] synonym: "A-esterase activity" BROAD [EC:3.1.8.1] synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1] -synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1] +synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [] synonym: "esterase B1" RELATED [EC:3.1.8.1] synonym: "esterase E4" RELATED [EC:3.1.8.1] synonym: "OPH" RELATED [EC:3.1.8.1] -synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1] -synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1] -synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1] -synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1] -synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1] +synonym: "organophosphate esterase activity" BROAD [] +synonym: "organophosphate hydrolase activity" BROAD [] +synonym: "organophosphorus acid anhydrase activity" BROAD [] +synonym: "organophosphorus hydrolase activity" BROAD [] +synonym: "paraoxon esterase activity" NARROW [] synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1] synonym: "paraoxonase activity" BROAD [EC:3.1.8.1] -synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1] -synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1] +synonym: "phosphotriesterase activity" NARROW [EC:3.1.8.1] +synonym: "pirimiphos-methyloxon esterase activity" NARROW [] xref: EC:3.1.8.1 xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN +xref: RHEA:18053 xref: UM-BBD_enzymeID:e0054 is_a: GO:0016791 ! phosphatase activity @@ -36062,6 +35991,7 @@ synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2] synonym: "paraoxonase activity" BROAD [EC:3.1.1.2] xref: EC:3.1.1.2 xref: MetaCyc:ARYLESTERASE-RXN +xref: RHEA:17309 xref: UM-BBD_reactionID:r0757 is_a: GO:0052689 ! carboxylic ester hydrolase activity @@ -36084,6 +36014,7 @@ synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1] synonym: "sulfatase activity" RELATED [EC:3.1.6.1] xref: EC:3.1.6.1 xref: MetaCyc:ARYLSULFAT-RXN +xref: RHEA:17261 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] @@ -36178,8 +36109,8 @@ xref: EC:2.6.1.1 xref: KEGG_REACTION:R00355 xref: MetaCyc:ASPAMINOTRANS-RXN xref: Reactome:R-HSA-70581 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]" -xref: Reactome:R-HSA-70592 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]" -xref: Reactome:R-HSA-70596 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]" +xref: Reactome:R-HSA-70592 "PXLP-K259-GOT1 dimer deaminates L-Asp" +xref: Reactome:R-HSA-70596 "GOT2 dimer deaminates L-Asp" xref: Reactome:R-HSA-70613 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]" xref: RHEA:21824 is_a: GO:0008483 ! transaminase activity @@ -36257,13 +36188,14 @@ is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group [Term] id: GO:0004074 -name: biliverdin reductase activity +name: biliverdin reductase (NAD(P)+) activity namespace: molecular_function def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24] synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24] xref: EC:1.3.1.24 xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN -xref: Reactome:R-HSA-189384 "Biliverdin is reduced to bilirubin" +xref: Reactome:R-HSA-189384 "BLVRA:Zn2+, BLVRB reduce BV to BIL" +xref: RHEA:15793 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -36275,6 +36207,7 @@ synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXA synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14] xref: EC:6.3.4.14 xref: MetaCyc:BIOTIN-CARBOXYL-RXN +xref: RHEA:13501 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] @@ -36309,6 +36242,7 @@ synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "HCS" RELATED [EC:6.3.4.15] xref: EC:6.3.4.15 xref: MetaCyc:BIOTINLIG-RXN +xref: RHEA:11756 is_a: GO:0018271 ! biotin-protein ligase activity [Term] @@ -36324,6 +36258,7 @@ synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11] synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11] xref: EC:6.3.4.11 xref: MetaCyc:6.3.4.11-RXN +xref: RHEA:24376 is_a: GO:0018271 ! biotin-protein ligase activity [Term] @@ -36346,6 +36281,7 @@ synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-fo synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9] xref: EC:6.3.4.9 xref: MetaCyc:6.3.4.9-RXN +xref: RHEA:23668 is_a: GO:0018271 ! biotin-protein ligase activity [Term] @@ -36363,6 +36299,7 @@ synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6. synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] xref: EC:6.3.4.10 xref: MetaCyc:6.3.4.10-RXN +xref: RHEA:11204 is_a: GO:0018271 ! biotin-protein ligase activity [Term] @@ -36697,6 +36634,7 @@ synonym: "cerebroside-sulphatase activity" EXACT [] xref: EC:3.1.6.8 xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN xref: Reactome:R-HSA-1606807 "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside" +xref: RHEA:21300 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] @@ -36724,6 +36662,7 @@ synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16] xref: EC:2.4.1.16 xref: MetaCyc:CHITIN-SYNTHASE-RXN +xref: RHEA:16637 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] @@ -36747,10 +36686,10 @@ id: GO:0004103 name: choline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12837] -synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32] -synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32] -synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32] -synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32] +synonym: "ATP:choline phosphotransferase activity" RELATED [] +synonym: "choline kinase (phosphorylating)" RELATED [] +synonym: "choline phosphokinase activity" RELATED [] +synonym: "choline-ethanolamine kinase activity" RELATED [] xref: EC:2.7.1.32 xref: KEGG_REACTION:R01021 xref: MetaCyc:CHOLINE-KINASE-RXN @@ -36944,6 +36883,7 @@ synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37] synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37] xref: EC:3.1.4.37 xref: MetaCyc:3.1.4.37-RXN +xref: RHEA:14489 is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] @@ -36987,9 +36927,11 @@ synonym: "cAMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT [] xref: EC:3.1.4 xref: MetaCyc:RXN0-5038 -xref: Reactome:R-HSA-111962 "cAMP hydrolysis by PDE 4" +xref: Reactome:R-HSA-111962 "PDE4A,C,D hydrolyse cAMP" xref: Reactome:R-HSA-418553 "cAMP degradation by Phosphodiesterases" xref: Reactome:R-HSA-9629675 "PDE3A,3B hydrolyses cAMP to AMP" +xref: Reactome:R-HSA-9644869 "p-S54-PDE4B hydrolyses cAMP" +xref: RHEA:25277 is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] @@ -37055,7 +36997,7 @@ synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22] xref: EC:4.2.1.22 xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN -xref: Reactome:R-HSA-1614524 "Cystathionine is formed from homocysteine and serine" +xref: Reactome:R-HSA-1614524 "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine" xref: RHEA:10112 is_a: GO:0016836 ! hydro-lyase activity @@ -37074,7 +37016,7 @@ synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" xref: EC:4.4.1.1 xref: KEGG_REACTION:R01001 xref: MetaCyc:CYSTAGLY-RXN -xref: Reactome:R-HSA-1614583 "Cleavage of cystathionine into cysteine" +xref: Reactome:R-HSA-1614583 "PXLP-K212-CTH cleaves L-Cystathionine" xref: RHEA:14005 is_a: GO:0016846 ! carbon-sulfur lyase activity @@ -37122,6 +37064,7 @@ synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT [] synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1] xref: EC:2.9.1.1 xref: MetaCyc:2.9.1.1-RXN +xref: RHEA:22728 is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -37177,6 +37120,7 @@ xref: EC:1.6.2.2 xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN xref: Reactome:R-HSA-198824 "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme" xref: Reactome:R-HSA-6806831 "CYB5Rs reduce MetHb to HbA" +xref: RHEA:46680 is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] @@ -37203,6 +37147,7 @@ synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1] xref: EC:1.9.3.1 xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN xref: Reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen" +xref: RHEA:11436 is_a: GO:0009055 ! electron transfer activity is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0015078 ! proton transmembrane transporter activity @@ -37224,6 +37169,7 @@ synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5] xref: EC:1.11.1.5 xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN +xref: RHEA:16581 is_a: GO:0004601 ! peroxidase activity [Term] @@ -37583,6 +37529,7 @@ synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC: synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] xref: EC:2.3.1.61 +xref: RHEA:15213 is_a: GO:0016751 ! S-succinyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -38002,6 +37949,7 @@ synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] xref: EC:1.5.5.1 xref: MetaCyc:1.5.5.1-RXN xref: Reactome:R-HSA-169270 "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2" +xref: RHEA:24052 is_a: GO:0009055 ! electron transfer activity is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor relationship: part_of GO:0022904 ! respiratory electron transport chain @@ -38016,6 +37964,7 @@ synonym: "elastase activity" RELATED [GOC:krc] synonym: "endoprotease activity" NARROW [] synonym: "proteasome endopeptidase activity" NARROW [] synonym: "proteinase" NARROW [] +xref: EC:3.4.99 xref: MetaCyc:RXN0-5195 xref: Reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded" xref: Reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha" @@ -38088,9 +38037,10 @@ xref: Reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2" xref: Reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)" xref: Reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1" xref: Reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4" +xref: Reactome:R-HSA-9614271 "Autocleavage of ADGRG6" xref: Reactome:R-HSA-983150 "Proteasomal cleavage of substrate" xref: Reactome:R-HSA-983158 "Trimming of peptides in ER" -is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides +is_a: GO:0008233 ! peptidase activity [Term] id: GO:0004176 @@ -38099,8 +38049,8 @@ namespace: molecular_function alt_id: GO:0004280 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah] synonym: "ATP-dependent proteolysis" RELATED [GOC:mah] +is_a: GO:0008233 ! peptidase activity is_a: GO:0016887 ! ATPase activity -is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004177 @@ -38108,6 +38058,14 @@ name: aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] xref: EC:3.4.11 +xref: EC:3.4.11.21 +xref: EC:3.4.11.5 +xref: EC:3.4.11.6 +xref: EC:3.4.11.9 +xref: MetaCyc:3.4.11.21-RXN +xref: MetaCyc:3.4.11.5-RXN +xref: MetaCyc:3.4.11.6-RXN +xref: MetaCyc:3.4.11.9-RXN xref: MetaCyc:RXN0-5052 xref: Reactome:R-HSA-1236954 "Trimming of peptides by IRAP in endocytic vesicles" xref: Reactome:R-HSA-2534096 "METAP1/2 demethylates GNAT1" @@ -38172,7 +38130,10 @@ id: GO:0004180 name: carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] +xref: EC:3.4.17.11 +xref: MetaCyc:3.4.17.11-RXN xref: Reactome:R-HSA-1247910 "CNDP2:2Mn2+ dimer hydrolyses CysGly" +xref: RHEA:28783 is_a: GO:0008238 ! exopeptidase activity [Term] @@ -38181,6 +38142,23 @@ name: metallocarboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] xref: EC:3.4.17 +xref: EC:3.4.17.1 +xref: EC:3.4.17.10 +xref: EC:3.4.17.17 +xref: EC:3.4.17.2 +xref: EC:3.4.17.21 +xref: EC:3.4.17.22 +xref: EC:3.4.17.3 +xref: EC:3.4.17.4 +xref: EC:3.4.17.6 +xref: MetaCyc:3.4.17.17-RXN +xref: MetaCyc:3.4.17.22-RXN +xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN +xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN +xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN +xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN +xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN +xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN xref: Reactome:R-HSA-2022378 "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)" xref: Reactome:R-HSA-2022379 "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)" xref: Reactome:R-HSA-2028294 "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)" @@ -38203,8 +38181,6 @@ synonym: "carboxypeptidase A activity" EXACT [] synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1] synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1] synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1] -xref: EC:3.4.17.1 -xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN is_obsolete: true replaced_by: GO:0004181 @@ -38223,8 +38199,6 @@ synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10] synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10] -xref: EC:3.4.17.10 -xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN is_obsolete: true replaced_by: GO:0004181 @@ -38250,8 +38224,6 @@ synonym: "lysine carboxypeptidase activity" EXACT [] synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3] synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3] -xref: EC:3.4.17.3 -xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 @@ -38262,6 +38234,12 @@ namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] synonym: "serine carboxypeptidase activity" EXACT [] xref: EC:3.4.16 +xref: EC:3.4.16.2 +xref: EC:3.4.16.5 +xref: EC:3.4.16.6 +xref: MetaCyc:3.4.16.2-RXN +xref: MetaCyc:3.4.16.5-RXN +xref: MetaCyc:3.4.16.6-RXN xref: Reactome:R-HSA-158251 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0070008 ! serine-type exopeptidase activity @@ -38281,8 +38259,6 @@ synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5] synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "vacuolar carboxypeptidase Y" NARROW [] -xref: EC:3.4.16.5 -xref: MetaCyc:3.4.16.5-RXN is_obsolete: true replaced_by: GO:0004185 @@ -38303,8 +38279,6 @@ synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6] synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6] synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6] synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6] -xref: EC:3.4.16.6 -xref: MetaCyc:3.4.16.6-RXN is_obsolete: true replaced_by: GO:0004185 @@ -38326,8 +38300,6 @@ synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2] synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "serine-type Pro-X carboxypeptidase activity" EXACT [] -xref: EC:3.4.16.2 -xref: MetaCyc:3.4.16.2-RXN is_obsolete: true replaced_by: GO:0004185 @@ -38348,8 +38320,6 @@ synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT [] synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] -xref: EC:3.4.17.17 -xref: MetaCyc:3.4.17.17-RXN is_obsolete: true replaced_by: GO:0004181 @@ -38364,6 +38334,28 @@ synonym: "aspartic protease activity" NARROW [] synonym: "aspartyl protease activity" NARROW [] synonym: "carboxyl protease activity" NARROW [] xref: EC:3.4.23 +xref: EC:3.4.23.1 +xref: EC:3.4.23.15 +xref: EC:3.4.23.20 +xref: EC:3.4.23.25 +xref: EC:3.4.23.32 +xref: EC:3.4.23.34 +xref: EC:3.4.23.35 +xref: EC:3.4.23.36 +xref: EC:3.4.23.4 +xref: EC:3.4.23.43 +xref: EC:3.4.23.5 +xref: MetaCyc:3.4.23.1-RXN +xref: MetaCyc:3.4.23.15-RXN +xref: MetaCyc:3.4.23.20-RXN +xref: MetaCyc:3.4.23.25-RXN +xref: MetaCyc:3.4.23.32-RXN +xref: MetaCyc:3.4.23.34-RXN +xref: MetaCyc:3.4.23.35-RXN +xref: MetaCyc:3.4.23.36-RXN +xref: MetaCyc:3.4.23.4-RXN +xref: MetaCyc:3.4.23.43-RXN +xref: MetaCyc:3.4.23.5-RXN xref: Reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1" xref: Reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2" xref: Reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" @@ -38387,8 +38379,6 @@ synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35] synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35] synonym: "barrierpepsin activity" EXACT [] synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35] -xref: EC:3.4.23.35 -xref: MetaCyc:3.4.23.35-RXN is_obsolete: true replaced_by: GO:0004190 @@ -38399,8 +38389,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin D activity" EXACT [] -xref: EC:3.4.23.5 -xref: MetaCyc:3.4.23.5-RXN is_obsolete: true replaced_by: GO:0004190 @@ -38419,8 +38407,6 @@ synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.3 synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34] synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34] synonym: "SMP" RELATED [EC:3.4.23.34] -xref: EC:3.4.23.34 -xref: MetaCyc:3.4.23.34-RXN is_obsolete: true replaced_by: GO:0004190 @@ -38441,8 +38427,6 @@ synonym: "pepsin activity" BROAD [EC:3.4.23.1] synonym: "pepsin D" RELATED [EC:3.4.23.1] synonym: "pepsin fortior" RELATED [EC:3.4.23.1] synonym: "pepsin R" RELATED [EC:3.4.23.1] -xref: EC:3.4.23.1 -xref: MetaCyc:3.4.23.1-RXN is_obsolete: true replaced_by: GO:0004190 @@ -38455,8 +38439,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15] synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15] synonym: "renin activity" EXACT [] -xref: EC:3.4.23.15 -xref: MetaCyc:3.4.23.15-RXN is_obsolete: true replaced_by: GO:0004190 @@ -38476,8 +38458,6 @@ synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25] synonym: "saccharopepsin activity" EXACT [] synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25] synonym: "yeast proteinase A" RELATED [EC:3.4.23.25] -xref: EC:3.4.23.25 -xref: MetaCyc:3.4.23.25-RXN is_obsolete: true replaced_by: GO:0004190 @@ -38491,6 +38471,26 @@ synonym: "lysosomal cysteine-type endopeptidase" NARROW [] synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis] synonym: "thiol endopeptidase activity" EXACT [] xref: EC:3.4.22 +xref: EC:3.4.22.1 +xref: EC:3.4.22.14 +xref: EC:3.4.22.15 +xref: EC:3.4.22.16 +xref: EC:3.4.22.27 +xref: EC:3.4.22.28 +xref: EC:3.4.22.34 +xref: EC:3.4.22.38 +xref: EC:3.4.22.40 +xref: EC:3.4.22.41 +xref: EC:3.4.22.8 +xref: MetaCyc:3.4.22.1-RXN +xref: MetaCyc:3.4.22.14-RXN +xref: MetaCyc:3.4.22.15-RXN +xref: MetaCyc:3.4.22.16-RXN +xref: MetaCyc:3.4.22.27-RXN +xref: MetaCyc:3.4.22.34-RXN +xref: MetaCyc:3.4.22.38-RXN +xref: MetaCyc:3.4.22.40-RXN +xref: MetaCyc:3.4.22.41-RXN xref: Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome" xref: Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9" xref: Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome" @@ -38551,7 +38551,7 @@ xref: Reactome:R-HSA-418845 "Activation of caspase-3" xref: Reactome:R-HSA-418846 "Caspase cleavage of UNC5A" xref: Reactome:R-HSA-418852 "Caspase cleavage of UNC5B" xref: Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1" -xref: Reactome:R-HSA-5357828 "RIP1 is cleaved by CASP8" +xref: Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8" xref: Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases" xref: Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor" xref: Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4" @@ -38561,6 +38561,14 @@ xref: Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL3 xref: Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex" xref: Reactome:R-HSA-933532 "Processing of caspases" xref: Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3" +xref: Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins" +xref: Reactome:R-HSA-9684273 "3CLp cleaves pp1a" +xref: Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11" +xref: Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4" +xref: Reactome:R-HSA-9684336 "nsp1-4 cleaves itself" +xref: Reactome:R-HSA-9684340 "3CLp cleaves pp1ab" +xref: Reactome:R-HSA-9684351 "pp1a cleaves itself" +xref: Reactome:R-HSA-9684352 "nsp3-4 cleaves itself" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008234 ! cysteine-type peptidase activity @@ -38718,8 +38726,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin B activity" EXACT [] synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1] synonym: "cathepsin II" RELATED [EC:3.4.22.1] -xref: EC:3.4.22.1 -xref: MetaCyc:3.4.22.1-RXN is_obsolete: true replaced_by: GO:0004197 @@ -38755,8 +38761,6 @@ synonym: "cathepsin Ba" RELATED [EC:3.4.22.16] synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16] synonym: "cathepsin H activity" EXACT [] synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16] -xref: EC:3.4.22.16 -xref: MetaCyc:3.4.22.16-RXN is_obsolete: true replaced_by: GO:0004197 @@ -38770,8 +38774,6 @@ synonym: "cathepsin K activity" EXACT [] synonym: "cathepsin O activity" EXACT [EC:3.4.22.38] synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38] synonym: "cathepsin X activity" EXACT [EC:3.4.22.38] -xref: EC:3.4.22.38 -xref: MetaCyc:3.4.22.38-RXN is_obsolete: true replaced_by: GO:0004197 @@ -38783,8 +38785,6 @@ def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close comment: This term was made obsolete because it represents a gene product. synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15] synonym: "cathepsin L activity" EXACT [] -xref: EC:3.4.22.15 -xref: MetaCyc:3.4.22.15-RXN is_obsolete: true replaced_by: GO:0004197 @@ -38795,8 +38795,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin S activity" EXACT [] -xref: EC:3.4.22.27 -xref: MetaCyc:3.4.22.27-RXN is_obsolete: true replaced_by: GO:0004197 @@ -38843,7 +38841,6 @@ xref: KEGG_REACTION:R02418 xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN is_obsolete: true consider: GO:0004843 -consider: GO:0036459 [Term] id: GO:0004222 @@ -38853,6 +38850,48 @@ def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypept synonym: "metalloendoprotease activity" NARROW [GOC:mah] synonym: "metalloendoproteinase activity" NARROW [GOC:mah] xref: EC:3.4.24 +xref: EC:3.4.24.11 +xref: EC:3.4.24.14 +xref: EC:3.4.24.17 +xref: EC:3.4.24.18 +xref: EC:3.4.24.19 +xref: EC:3.4.24.21 +xref: EC:3.4.24.22 +xref: EC:3.4.24.23 +xref: EC:3.4.24.24 +xref: EC:3.4.24.35 +xref: EC:3.4.24.37 +xref: EC:3.4.24.55 +xref: EC:3.4.24.56 +xref: EC:3.4.24.57 +xref: EC:3.4.24.59 +xref: EC:3.4.24.61 +xref: EC:3.4.24.64 +xref: EC:3.4.24.69 +xref: EC:3.4.24.70 +xref: EC:3.4.24.71 +xref: EC:3.4.24.72 +xref: MetaCyc:3.4.24.11-RXN +xref: MetaCyc:3.4.24.14-RXN +xref: MetaCyc:3.4.24.17-RXN +xref: MetaCyc:3.4.24.18-RXN +xref: MetaCyc:3.4.24.19-RXN +xref: MetaCyc:3.4.24.21-RXN +xref: MetaCyc:3.4.24.22-RXN +xref: MetaCyc:3.4.24.23-RXN +xref: MetaCyc:3.4.24.24-RXN +xref: MetaCyc:3.4.24.35-RXN +xref: MetaCyc:3.4.24.37-RXN +xref: MetaCyc:3.4.24.55-RXN +xref: MetaCyc:3.4.24.56-RXN +xref: MetaCyc:3.4.24.57-RXN +xref: MetaCyc:3.4.24.59-RXN +xref: MetaCyc:3.4.24.61-RXN +xref: MetaCyc:3.4.24.64-RXN +xref: MetaCyc:3.4.24.69-RXN +xref: MetaCyc:3.4.24.70-RXN +xref: MetaCyc:3.4.24.71-RXN +xref: MetaCyc:3.4.24.72-RXN xref: Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR" xref: Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17" xref: Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors" @@ -38962,8 +39001,6 @@ synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "peptidase alpha" RELATED [EC:3.4.17.4] synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4] -xref: EC:3.4.17.4 -xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 @@ -38986,8 +39023,6 @@ synonym: "MMP-2" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24] synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24] synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24] -xref: EC:3.4.24.24 -xref: MetaCyc:3.4.24.24-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39010,8 +39045,6 @@ synonym: "MMP 9" RELATED [EC:3.4.24.35] synonym: "MMP-9" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35] synonym: "type V collagenase activity" EXACT [EC:3.4.24.35] -xref: EC:3.4.24.35 -xref: MetaCyc:3.4.24.35-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39053,8 +39086,6 @@ synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56] synonym: "insulinase activity" EXACT [EC:3.4.24.56] synonym: "insulysin activity" EXACT [] synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56] -xref: EC:3.4.24.56 -xref: MetaCyc:3.4.24.56-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39068,8 +39099,6 @@ synonym: "interstitial collagenase activity" EXACT [] synonym: "matrix metalloproteinase 1" EXACT [] synonym: "MMP-1" EXACT [] synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7] -xref: EC:3.4.24.7 -xref: MetaCyc:3.4.24.7-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39111,8 +39140,6 @@ synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23] synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23] synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23] synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23] -xref: EC:3.4.24.23 -xref: MetaCyc:3.4.24.23-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39153,8 +39180,6 @@ synonym: "meprin-a" RELATED [EC:3.4.24.18] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PPH" RELATED [EC:3.4.24.18] -xref: EC:3.4.24.18 -xref: MetaCyc:3.4.24.18-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39192,8 +39217,6 @@ synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT synonym: "MPP" EXACT [] synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64] synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64] -xref: EC:3.4.24.64 -xref: MetaCyc:3.4.24.64-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39230,8 +39253,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "MIP" BROAD [] synonym: "mitochondrial intermediate peptidase activity" EXACT [] synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59] -xref: EC:3.4.24.59 -xref: MetaCyc:3.4.24.59-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39243,7 +39264,6 @@ def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins comment: This term was made obsolete because it represents a gene product. synonym: "IMP" BROAD [] synonym: "mitochondrial inner membrane peptidase activity" EXACT [] -xref: EC:3.4.99 is_obsolete: true replaced_by: GO:0004175 @@ -39273,8 +39293,6 @@ synonym: "neprilysin activity" EXACT [] synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11] synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11] -xref: EC:3.4.24.11 -xref: MetaCyc:3.4.24.11-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39319,8 +39337,6 @@ synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37] synonym: "saccharolysin activity" EXACT [] synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37] synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37] -xref: EC:3.4.24.37 -xref: MetaCyc:3.4.24.37-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39340,8 +39356,6 @@ synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "stromelysin" RELATED [EC:3.4.24.17] synonym: "stromelysin 1 activity" EXACT [] synonym: "transin activity" EXACT [EC:3.4.24.17] -xref: EC:3.4.24.17 -xref: MetaCyc:3.4.24.17-RXN is_obsolete: true replaced_by: GO:0004222 @@ -39354,7 +39368,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 11" EXACT [] synonym: "MMP-11" EXACT [] synonym: "stromelysin 3 activity" EXACT [] -xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 @@ -39403,7 +39416,102 @@ def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypept subset: goslim_chembl synonym: "blood coagulation factor activity" RELATED [] synonym: "serine elastase activity" RELATED [GOC:krc] +xref: EC:3.4.19.1 xref: EC:3.4.21 +xref: EC:3.4.21.1 +xref: EC:3.4.21.10 +xref: EC:3.4.21.102 +xref: EC:3.4.21.20 +xref: EC:3.4.21.21 +xref: EC:3.4.21.22 +xref: EC:3.4.21.26 +xref: EC:3.4.21.27 +xref: EC:3.4.21.34 +xref: EC:3.4.21.35 +xref: EC:3.4.21.36 +xref: EC:3.4.21.38 +xref: EC:3.4.21.39 +xref: EC:3.4.21.4 +xref: EC:3.4.21.41 +xref: EC:3.4.21.42 +xref: EC:3.4.21.43 +xref: EC:3.4.21.45 +xref: EC:3.4.21.46 +xref: EC:3.4.21.47 +xref: EC:3.4.21.48 +xref: EC:3.4.21.5 +xref: EC:3.4.21.53 +xref: EC:3.4.21.54 +xref: EC:3.4.21.59 +xref: EC:3.4.21.6 +xref: EC:3.4.21.61 +xref: EC:3.4.21.62 +xref: EC:3.4.21.68 +xref: EC:3.4.21.69 +xref: EC:3.4.21.7 +xref: EC:3.4.21.71 +xref: EC:3.4.21.73 +xref: EC:3.4.21.75 +xref: EC:3.4.21.78 +xref: EC:3.4.21.79 +xref: EC:3.4.21.83 +xref: EC:3.4.21.87 +xref: EC:3.4.21.88 +xref: EC:3.4.21.89 +xref: EC:3.4.21.9 +xref: EC:3.4.21.92 +xref: EC:3.4.21.93 +xref: EC:3.4.21.94 +xref: EC:3.4.24.3 +xref: EC:3.4.24.34 +xref: EC:3.4.24.7 +xref: MetaCyc:3.4.21.1-RXN +xref: MetaCyc:3.4.21.10-RXN +xref: MetaCyc:3.4.21.102-RXN +xref: MetaCyc:3.4.21.20-RXN +xref: MetaCyc:3.4.21.21-RXN +xref: MetaCyc:3.4.21.22-RXN +xref: MetaCyc:3.4.21.26-RXN +xref: MetaCyc:3.4.21.27-RXN +xref: MetaCyc:3.4.21.34-RXN +xref: MetaCyc:3.4.21.35-RXN +xref: MetaCyc:3.4.21.36-RXN +xref: MetaCyc:3.4.21.38-RXN +xref: MetaCyc:3.4.21.39-RXN +xref: MetaCyc:3.4.21.4-RXN +xref: MetaCyc:3.4.21.41-RXN +xref: MetaCyc:3.4.21.42-RXN +xref: MetaCyc:3.4.21.43-RXN +xref: MetaCyc:3.4.21.45-RXN +xref: MetaCyc:3.4.21.46-RXN +xref: MetaCyc:3.4.21.47-RXN +xref: MetaCyc:3.4.21.48-RXN +xref: MetaCyc:3.4.21.5-RXN +xref: MetaCyc:3.4.21.53-RXN +xref: MetaCyc:3.4.21.54-RXN +xref: MetaCyc:3.4.21.59-RXN +xref: MetaCyc:3.4.21.6-RXN +xref: MetaCyc:3.4.21.61-RXN +xref: MetaCyc:3.4.21.62-RXN +xref: MetaCyc:3.4.21.68-RXN +xref: MetaCyc:3.4.21.69-RXN +xref: MetaCyc:3.4.21.7-RXN +xref: MetaCyc:3.4.21.71-RXN +xref: MetaCyc:3.4.21.73-RXN +xref: MetaCyc:3.4.21.75-RXN +xref: MetaCyc:3.4.21.78-RXN +xref: MetaCyc:3.4.21.79-RXN +xref: MetaCyc:3.4.21.83-RXN +xref: MetaCyc:3.4.21.87-RXN +xref: MetaCyc:3.4.21.88-RXN +xref: MetaCyc:3.4.21.89-RXN +xref: MetaCyc:3.4.21.9-RXN +xref: MetaCyc:3.4.21.92-RXN +xref: MetaCyc:3.4.21.93-RXN +xref: MetaCyc:3.4.21.94-RXN +xref: MetaCyc:3.4.24.34-RXN +xref: MetaCyc:3.4.24.7-RXN +xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN xref: Reactome:R-HSA-114697 "Thrombin-mediated activation of Proteinase-activated receptors" xref: Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein" xref: Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage" @@ -39557,6 +39665,16 @@ xref: Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1" xref: Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2" xref: Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1" xref: Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4" +xref: Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin" +xref: Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1" +xref: Reactome:R-HSA-9662786 "FURIN cleaves ADAM17" +xref: Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin" +xref: Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L" +xref: Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa" +xref: Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa" +xref: Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)" +xref: Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2" +xref: Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis" xref: Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b" xref: Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b" xref: Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b" @@ -39570,8 +39688,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54] comment: This term was made obsolete because it represents a gene product. synonym: "gamma-renin activity" EXACT [] -xref: EC:3.4.21.54 -xref: MetaCyc:3.4.21.54-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39585,8 +39701,6 @@ synonym: "acylaminoacyl-peptidase activity" EXACT [] synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1] -xref: EC:3.4.19.1 -xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39610,8 +39724,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin G activity" EXACT [] synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20] synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20] -xref: EC:3.4.21.20 -xref: MetaCyc:3.4.21.20-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39627,8 +39739,6 @@ synonym: "cerevisin activity" EXACT [] synonym: "peptidase beta" RELATED [EC:3.4.21.48] synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48] synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48] -xref: EC:3.4.21.48 -xref: MetaCyc:3.4.21.48-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39652,8 +39762,6 @@ synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1] synonym: "enzeon" RELATED [EC:3.4.21.1] synonym: "quimar" RELATED [EC:3.4.21.1] synonym: "quimotrase activity" EXACT [EC:3.4.21.1] -xref: EC:3.4.21.1 -xref: MetaCyc:3.4.21.1-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39699,8 +39807,6 @@ def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsin comment: This term was made obsolete because it represents a gene product. synonym: "enterokinase activity" RELATED [EC:3.4.21.9] synonym: "enteropeptidase activity" EXACT [] -xref: EC:3.4.21.9 -xref: MetaCyc:3.4.21.9-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39719,8 +39825,6 @@ synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3. synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75] synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75] synonym: "SPC3" RELATED [EC:3.4.21.75] -xref: EC:3.4.21.75 -xref: MetaCyc:3.4.21.75-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39738,8 +39842,6 @@ synonym: "HuTPS" RELATED [EC:3.4.21.78] synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78] synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78] synonym: "TSP-1" RELATED [EC:3.4.21.78] -xref: EC:3.4.21.78 -xref: MetaCyc:3.4.21.78-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39757,8 +39859,6 @@ synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79] synonym: "granzyme B activity" EXACT [] synonym: "granzyme G" RELATED [EC:3.4.21.79] synonym: "granzyme H" RELATED [EC:3.4.21.79] -xref: EC:3.4.21.79 -xref: MetaCyc:3.4.21.79-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39770,8 +39870,6 @@ def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and P comment: This term was made obsolete because it represents a gene product. synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71] synonym: "pancreatic elastase II activity" EXACT [] -xref: EC:3.4.21.71 -xref: MetaCyc:3.4.21.71-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39787,8 +39885,6 @@ synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7] synonym: "plasmin activity" EXACT [] synonym: "serum tryptase activity" EXACT [EC:3.4.21.7] synonym: "thrombolysin" RELATED [EC:3.4.21.7] -xref: EC:3.4.21.7 -xref: MetaCyc:3.4.21.7-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39806,8 +39902,6 @@ synonym: "acrozonase activity" EXACT [EC:3.4.21.10] synonym: "alpha-acrosin" RELATED [EC:3.4.21.10] synonym: "beta-acrosin" RELATED [EC:3.4.21.10] synonym: "psi-acrosin" RELATED [EC:3.4.21.10] -xref: EC:3.4.21.10 -xref: MetaCyc:3.4.21.10-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39823,8 +39917,6 @@ synonym: "PC1 activity" NARROW [EC:3.4.21.93] synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93] synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93] synonym: "proprotein convertase 1 activity" EXACT [] -xref: EC:3.4.21.93 -xref: MetaCyc:3.4.21.93-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39839,8 +39931,6 @@ synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94] synonym: "PC2 activity" NARROW [EC:3.4.21.94] synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94] synonym: "proprotein convertase 2 activity" EXACT [] -xref: EC:3.4.21.94 -xref: MetaCyc:3.4.21.94-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39857,8 +39947,6 @@ synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "prolyl oligopeptidase activity" EXACT [] -xref: EC:3.4.21.26 -xref: MetaCyc:3.4.21.26-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39869,7 +39957,6 @@ namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "subtilase activity" EXACT [] -xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 @@ -39900,8 +39987,6 @@ synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61] synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61] synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61] -xref: EC:3.4.21.61 -xref: MetaCyc:3.4.21.61-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39950,8 +40035,6 @@ synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62] synonym: "superase activity" EXACT [EC:3.4.21.62] synonym: "thermoase" BROAD [EC:3.4.21.62] synonym: "thermoase PC 10" RELATED [EC:3.4.21.62] -xref: EC:3.4.21.62 -xref: MetaCyc:3.4.21.62-RXN is_obsolete: true replaced_by: GO:0004252 @@ -39983,8 +40066,6 @@ synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35] synonym: "tissue kallikrein activity" EXACT [] synonym: "urinary kallikrein" RELATED [EC:3.4.21.35] synonym: "urokallikrein" RELATED [EC:3.4.21.35] -xref: EC:3.4.21.35 -xref: MetaCyc:3.4.21.35-RXN is_obsolete: true replaced_by: GO:0004252 @@ -40000,8 +40081,6 @@ synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10] synonym: "tripeptidyl-peptidase II activity" EXACT [] -xref: EC:3.4.14.10 -xref: MetaCyc:3.4.14.10-RXN is_obsolete: true replaced_by: GO:0008240 @@ -40022,8 +40101,6 @@ synonym: "tripcellim" RELATED [EC:3.4.21.4] synonym: "trypsin activity" EXACT [] synonym: "tryptar" RELATED [EC:3.4.21.4] synonym: "trypure" RELATED [EC:3.4.21.4] -xref: EC:3.4.21.4 -xref: MetaCyc:3.4.21.4-RXN is_obsolete: true replaced_by: GO:0004252 @@ -40092,7 +40169,7 @@ synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17] xref: EC:4.2.1.17 xref: MetaCyc:ENOYL-COA-HYDRAT-RXN xref: Reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA" -xref: Reactome:R-HSA-70870 "methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA" +xref: Reactome:R-HSA-70870 "ECHS1 hydrates methacrylyl-CoA" xref: Reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA" xref: Reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA" xref: Reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA" @@ -40134,6 +40211,7 @@ xref: Reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to Ma xref: Reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA" xref: Reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA" xref: Reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA" +xref: RHEA:19037 xref: UM-BBD_enzymeID:e0397 is_a: GO:0016803 ! ether hydrolase activity @@ -40267,6 +40345,7 @@ synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11] synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11] xref: EC:3.6.1.11 xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN +xref: RHEA:21528 is_a: GO:0016462 ! pyrophosphatase activity [Term] @@ -40312,6 +40391,7 @@ synonym: "fatty-acid synthase activity" EXACT [] xref: EC:2.3.1.85 xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN xref: Reactome:R-HSA-75872 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O" +xref: RHEA:14993 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -40331,6 +40411,7 @@ synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38] xref: EC:2.3.1.38 xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN +xref: RHEA:41788 is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016418 ! S-acetyltransferase activity @@ -40392,6 +40473,7 @@ synonym: "KASI" RELATED [EC:2.3.1.41] synonym: "ketoacyl-ACP synthase activity" EXACT [] xref: EC:2.3.1.41 xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN +xref: RHEA:22836 is_a: GO:0004312 ! fatty acid synthase activity [Term] @@ -40415,6 +40497,7 @@ synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT xref: EC:1.1.1.100 xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN xref: Reactome:R-HSA-8862152 "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP" +xref: RHEA:17397 is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -40488,6 +40571,7 @@ synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14] xref: EC:3.1.2.14 xref: MetaCyc:3.1.2.14-RXN xref: MetaCyc:PWY-5142 +xref: RHEA:15057 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] @@ -40500,6 +40584,7 @@ synonym: "fatty acyl CoA synthase activity" EXACT [] synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86] xref: EC:2.3.1.86 xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN +xref: RHEA:22896 is_a: GO:0016408 ! C-acyltransferase activity [Term] @@ -40557,6 +40642,7 @@ synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reduct synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.2 xref: MetaCyc:1.18.1.2-RXN +xref: RHEA:20125 is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity [Term] @@ -40603,6 +40689,7 @@ xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN xref: Reactome:R-HSA-197958 "Conversion of cytosolic THF to THF-polyglutamate" xref: Reactome:R-HSA-200681 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate" xref: Reactome:R-HSA-200682 "Conversion of mitochondrial THF to THF-polyglutamate" +xref: RHEA:10580 is_a: GO:0016881 ! acid-amino acid ligase activity relationship: part_of GO:0046901 ! tetrahydrofolylpolyglutamate biosynthetic process @@ -41073,7 +41160,7 @@ synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15] xref: EC:4.1.1.15 xref: MetaCyc:GLUTDECARBOX-RXN -xref: Reactome:R-HSA-888572 "Synthesis of GABA by GAD1" +xref: Reactome:R-HSA-888572 "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA" xref: Reactome:R-HSA-888577 "Synthesis of GABA by GAD2" xref: RHEA:17785 is_a: GO:0016831 ! carboxy-lyase activity @@ -41510,7 +41597,7 @@ xref: EC:2.1.2.1 xref: MetaCyc:GLYOHMETRANS-RXN xref: Reactome:R-HSA-200651 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine" xref: Reactome:R-HSA-200735 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine" -xref: Reactome:R-HSA-5694137 "SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine" +xref: Reactome:R-HSA-5694137 "PXLP-K280-SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine" xref: Reactome:R-HSA-71249 "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly" xref: RHEA:15481 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity @@ -41520,7 +41607,7 @@ id: GO:0004373 name: glycogen (starch) synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11] -synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11] +synonym: "glycogen (starch) synthetase activity" EXACT [] synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11] @@ -41535,6 +41622,7 @@ xref: Reactome:R-HSA-3322009 "GYS2 catalyzes the polyglucosylation of oligoGlc-G xref: Reactome:R-HSA-3322041 "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1" xref: Reactome:R-HSA-3828061 "Defective GYS1 does not transfer glucose to growing glycogen chains" xref: Reactome:R-HSA-3858506 "Defective GYS2 does not transfer glucose to growing glycogen chains" +xref: RHEA:18549 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -41563,7 +41651,8 @@ synonym: "P-protein" NARROW [EC:1.4.4.2] synonym: "protein P1" NARROW [EC:1.4.4.2] xref: EC:1.4.4.2 xref: MetaCyc:GCVP-RXN -xref: Reactome:R-HSA-5693967 "GLDC dimer:2xPXLP decarboxylates Gly" +xref: Reactome:R-HSA-5693967 "PXLP-K754-GLDC dimer decarboxylates Gly" +xref: RHEA:24304 is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor [Term] @@ -41628,6 +41717,7 @@ xref: EC:2.3.1.97 xref: MetaCyc:2.3.1.97-RXN xref: Reactome:R-HSA-184392 "N-myristoylation of GAG polyprotein by NMT2" xref: Reactome:R-HSA-2534087 "NMT1/2 transfer MYS to GNAT1" +xref: RHEA:15521 is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0019107 ! myristoyltransferase activity @@ -41654,6 +41744,7 @@ xref: EC:2.4.1.40 xref: MetaCyc:2.4.1.40-RXN xref: Reactome:R-HSA-9033959 "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC" xref: Reactome:R-HSA-9034042 "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec" +xref: RHEA:19021 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein @@ -41768,15 +41859,10 @@ subset: goslim_generic subset: goslim_pir subset: goslim_yeast synonym: "ATP-dependent helicase activity" EXACT [] -xref: Reactome:R-HSA-167097 "HIV Promoter Opening: First Transition" xref: Reactome:R-HSA-169461 "MCM8 mediated fork unwinding" xref: Reactome:R-HSA-169468 "MCM2-7 mediated fork unwinding" +xref: Reactome:R-HSA-5686410 "BLM mediates dissolution of double Holliday junction" xref: Reactome:R-HSA-5690996 "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA" -xref: Reactome:R-HSA-75949 "RNA Polymerase II Promoter Opening: First Transition" -xref: Reactome:R-HSA-9613490 "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition" -xref: Reactome:R-HSA-9613494 "Unwinding of DNA for the Nascent Transcript: Second Transition" -xref: Reactome:R-HSA-9613497 "Unwinding DNA for the nascent transcript" -xref: Reactome:R-HSA-9613498 "Unwinding of DNA for the nascent HIV-1 transcript" is_a: GO:0016887 ! ATPase activity [Term] @@ -41964,6 +42050,7 @@ xref: Reactome:R-HSA-3697008 "CREBBP acetylates histone H2B, H3, H4" xref: Reactome:R-HSA-3697920 "CLOCK acetylates lysine-10 of histone H3, H4" xref: Reactome:R-HSA-5144542 "CLOCK acetylates lysine-15 of histone H3, H4" xref: Reactome:R-HSA-5250938 "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9" +xref: RHEA:21992 is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity relationship: part_of GO:0016573 ! histone acetylation @@ -41983,6 +42070,7 @@ xref: Reactome:R-HSA-3782655 "HDAC10 deacetylates histone" xref: Reactome:R-HSA-427514 "eNoSC deacetylates histone H3" xref: Reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3" xref: Reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53" +xref: RHEA:58196 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0033558 ! protein deacetylase activity relationship: part_of GO:0016575 ! histone deacetylation @@ -41999,6 +42087,7 @@ synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1 synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17] xref: EC:4.4.1.17 xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN +xref: RHEA:22648 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] @@ -42772,6 +42861,7 @@ synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86] xref: EC:1.1.1.86 xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN +xref: RHEA:22068 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -42813,6 +42903,7 @@ synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4] xref: EC:1.1.2.4 xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:13521 is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor @@ -42851,6 +42942,7 @@ synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3] synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3] xref: EC:1.1.2.3 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:19909 is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor @@ -43222,6 +43314,7 @@ synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylas xref: EC:2.1.2.9 xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN xref: Reactome:R-HSA-5389841 "MTFMT formylates methionyl-tRNA" +xref: RHEA:24380 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0006413 ! translational initiation @@ -43237,6 +43330,7 @@ synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (me synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16] xref: EC:2.1.1.16 xref: MetaCyc:2.1.1.16-RXN +xref: RHEA:17549 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -43252,6 +43346,9 @@ synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" xref: EC:2.1.1.56 xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase" +xref: Reactome:R-HSA-9684016 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs" +xref: Reactome:R-HSA-9684017 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)" +xref: Reactome:R-HSA-9684018 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity relationship: part_of GO:0006370 ! 7-methylguanosine mRNA capping @@ -43268,6 +43365,9 @@ synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] xref: EC:2.1.1.57 xref: MetaCyc:2.1.1.57-RXN +xref: Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)" +xref: Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)" +xref: Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs" is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity @@ -43285,6 +43385,7 @@ xref: EC:2.7.7.50 xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN xref: Reactome:R-HSA-77081 "Formation of the CE:GMP intermediate complex" xref: Reactome:R-HSA-77083 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA" +xref: RHEA:54592 is_a: GO:0008192 ! RNA guanylyltransferase activity [Term] @@ -43743,6 +43844,7 @@ synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXA synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3] xref: EC:1.14.17.3 xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN +xref: RHEA:21452 is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] @@ -43758,7 +43860,7 @@ synonym: "phenylalanine hydroxylase activity" EXACT [] xref: EC:1.14.16.1 xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN xref: Reactome:R-HSA-5649483 "Defective PAH does not hydroxylate L-Phe to L-Tyr" -xref: Reactome:R-HSA-71118 "PAH tetramer hydroxylates L-Phe to L-Tyr" +xref: Reactome:R-HSA-71118 "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr" xref: RHEA:20273 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen @@ -43802,6 +43904,7 @@ xref: Reactome:R-HSA-193997 "CYP11B1 oxidises 11DCORT" xref: Reactome:R-HSA-194017 "CYP11B2 oxidises 11DCORST to CORST" xref: Reactome:R-HSA-5580292 "Defective CYP11B1 does not oxidise 11DCORT" xref: Reactome:R-HSA-5600598 "Defective CYP11B2 does not oxidise 11DCORST" +xref: RHEA:15629 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen @@ -43913,6 +44016,7 @@ synonym: "SAT-3" RELATED [EC:2.4.99.10] synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10] xref: EC:2.4.99.10 xref: MetaCyc:2.4.99.10-RXN +xref: RHEA:18913 is_a: GO:0008373 ! sialyltransferase activity [Term] @@ -44145,8 +44249,6 @@ synonym: "tRNA 5' leader endonuclease activity" EXACT [] xref: EC:3.1.26.5 xref: MetaCyc:3.1.26.5-RXN xref: Reactome:R-HSA-5696810 "RNase P cleaves the 5' end of pre-tRNA" -xref: Reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript" -xref: Reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript" xref: Wikipedia:RNase_P is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters @@ -44381,6 +44483,7 @@ synonym: "O-glucosyl hydrolase activity" EXACT [] xref: EC:3.2.1 xref: Reactome:R-HSA-5694563 "ABHD10 hydrolyses MPAG" xref: Reactome:R-HSA-6786652 "CHIT1 hydrolyses CHIT to 3xADGP" +xref: Reactome:R-HSA-9661820 "Bacterial GUSB hydrolyses BDG to BIL" is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] @@ -44426,6 +44529,7 @@ synonym: "melibiase activity" EXACT [] xref: EC:3.2.1.22 xref: MetaCyc:ALPHAGALACTOSID-RXN xref: Reactome:R-HSA-1605736 "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers" +xref: RHEA:28663 is_a: GO:0015925 ! galactosidase activity [Term] @@ -44488,6 +44592,7 @@ synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51] xref: EC:3.2.1.51 xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN xref: Reactome:R-HSA-5693807 "FUCA1 hydrolyses NGP:1,6-GlcNAc" +xref: RHEA:12288 is_a: GO:0015928 ! fucosidase activity [Term] @@ -44613,6 +44718,7 @@ xref: Reactome:R-HSA-2162227 "GUSB tetramer hydrolyses (HA)2" xref: Reactome:R-HSA-2318373 "Defective GUSB does not hydrolyse (HA)2" xref: Reactome:R-HSA-9036068 "Defective GUSB does not hydrolyse GlcA-1,3-GlcNAc" xref: Reactome:R-HSA-9036070 "Defective GUSB does not hydrolyse CS/HS precursor" +xref: RHEA:17633 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -44659,6 +44765,7 @@ synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130] xref: EC:3.2.1.130 xref: MetaCyc:3.2.1.130-RXN xref: Reactome:R-HSA-964759 "Alternative endo-mannosidase I route" +xref: RHEA:54824 is_a: GO:0004559 ! alpha-mannosidase activity [Term] @@ -44715,6 +44822,7 @@ synonym: "mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity" EXACT [] xref: EC:3.2.1.114 xref: MetaCyc:3.2.1.114-RXN xref: Reactome:R-HSA-975814 "Trimming of mannoses on the alpha1,6 arm by MAN2A1" +xref: RHEA:56052 is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity [Term] @@ -44731,6 +44839,7 @@ xref: EC:3.2.1.106 xref: MetaCyc:3.2.1.106-RXN xref: Reactome:R-HSA-4793947 "Defective MOGS does not cleave glucose from an N-glycosylated protein" xref: Reactome:R-HSA-532678 "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase" +xref: RHEA:55988 is_a: GO:0015926 ! glucosidase activity [Term] @@ -44772,6 +44881,7 @@ xref: KEGG_REACTION:R00802 xref: MetaCyc:RXN-1461 xref: Reactome:R-HSA-189069 "sucrose + H2O => glucose + fructose" xref: Reactome:R-HSA-5659926 "Defective SI does not hydrolyze Suc" +xref: RHEA:33795 is_a: GO:0004564 ! beta-fructofuranosidase activity is_a: GO:0090599 ! alpha-glucosidase activity @@ -44796,6 +44906,7 @@ xref: EC:2.4.1.141 xref: MetaCyc:2.4.1.141-RXN xref: Reactome:R-HSA-446207 "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP" xref: Reactome:R-HSA-5633241 "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP" +xref: RHEA:23380 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] @@ -44810,6 +44921,7 @@ xref: EC:2.4.1.142 xref: MetaCyc:2.4.1.142-RXN xref: Reactome:R-HSA-446218 "Addition of the first mannose to the N-glycan precursor by ALG1" xref: Reactome:R-HSA-4549382 "Defective ALG1 does not transfer the first Man to the N-glycan precursor" +xref: RHEA:13865 is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity [Term] @@ -44980,6 +45092,7 @@ xref: EC:2.6.1.13 xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-70654 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]" xref: Reactome:R-HSA-70666 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]" +xref: RHEA:13877 is_a: GO:0008483 ! transaminase activity [Term] @@ -45073,6 +45186,7 @@ synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT [] synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] xref: EC:1.2.4.2 xref: MetaCyc:2OXOGLUTDECARB-RXN +xref: RHEA:12188 is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] @@ -45189,6 +45303,7 @@ synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5 synonym: "PGL" RELATED [EC:4.3.2.5] xref: EC:4.3.2.5 xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN +xref: RHEA:20924 is_a: GO:0016842 ! amidine-lyase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -45295,6 +45410,7 @@ synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activit xref: EC:2.1.1.28 xref: MetaCyc:2.1.1.28-RXN xref: Reactome:R-HSA-209903 "Noradrenaline is converted to adrenaline" +xref: RHEA:12176 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity @@ -45361,6 +45477,7 @@ synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43 xref: EC:2.3.1.43 xref: MetaCyc:2.3.1.43-RXN xref: Reactome:R-HSA-264695 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)" +xref: RHEA:21204 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -45546,7 +45663,7 @@ synonym: "SerA" RELATED [EC:1.1.1.95] synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95] xref: EC:1.1.1.95 xref: MetaCyc:PGLYCDEHYDROG-RXN -xref: Reactome:R-HSA-977348 "3-phosphoglycerate is dehydrogenated" +xref: Reactome:R-HSA-977348 "PHGHD tetramer dehydrogenates 3PG" xref: RHEA:12641 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -45574,7 +45691,7 @@ xref: EC:2.7.2.3 xref: KEGG_REACTION:R01512 xref: MetaCyc:PHOSGLYPHOS-RXN xref: Reactome:R-HSA-70486 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate" -xref: Reactome:R-HSA-71850 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP" +xref: Reactome:R-HSA-71850 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP" xref: RHEA:14801 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor @@ -45798,6 +45915,7 @@ xref: MetaCyc:PHOSCHOL-RXN xref: Reactome:R-HSA-1483142 "PC is transphosphatidylated to PG by PLD1-4/6" xref: Reactome:R-HSA-1483182 "PC is hydrolyzed to PA and choline by PLD1/2" xref: Reactome:R-HSA-2029471 "Hydrolysis of PC to PA by PLD" +xref: RHEA:14445 is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity @@ -45831,6 +45949,7 @@ synonym: "phosphopantothenoylcysteine synthetase activity" EXACT [] xref: EC:6.3.2.5 xref: MetaCyc:P-PANTOCYSLIG-RXN xref: Reactome:R-HSA-196753 "2xPPCS ligates PPanK with Cys" +xref: RHEA:19397 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] @@ -46099,7 +46218,7 @@ def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3] xref: EC:3.1.3.3 xref: MetaCyc:PSERPHOSPHA-RXN -xref: Reactome:R-HSA-977324 "phosphoserine is dephosphorylated" +xref: Reactome:R-HSA-977324 "PSPH:Mg2+ dimer dephosphorylates O-P-Ser" is_a: GO:0016791 ! phosphatase activity [Term] @@ -46122,7 +46241,7 @@ synonym: "PSAT activity" EXACT [EC:2.6.1.52] synonym: "SerC" RELATED [EC:2.6.1.52] xref: EC:2.6.1.52 xref: MetaCyc:PSERTRANSAM-RXN -xref: Reactome:R-HSA-977333 "3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate" +xref: Reactome:R-HSA-977333 "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA" xref: RHEA:14329 is_a: GO:0008483 ! transaminase activity @@ -46135,6 +46254,7 @@ xref: EC:3.2.1.143 xref: MetaCyc:3.2.1.143-RXN xref: Reactome:R-HSA-5651828 "PARG dePARylates PARP1,PARP2" xref: Reactome:R-HSA-8952903 "ADPRHL2 hydrolyses poly(ADP-ribose)" +xref: RHEA:52216 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -46168,6 +46288,7 @@ synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33] xref: EC:3.1.3.33 xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN xref: Reactome:R-HSA-77078 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme" +xref: RHEA:11008 is_a: GO:0098518 ! polynucleotide phosphatase activity relationship: part_of GO:0098507 ! polynucleotide 5' dephosphorylation @@ -46197,6 +46318,7 @@ synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19] xref: EC:2.7.7.19 xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN xref: Reactome:R-HSA-72185 "mRNA polyadenylation" +xref: RHEA:11332 is_a: GO:0070566 ! adenylyltransferase activity [Term] @@ -46225,6 +46347,7 @@ xref: Reactome:R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to muci xref: Reactome:R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins" xref: Reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23" xref: Reactome:R-HSA-913675 "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens" +xref: Reactome:R-HSA-9683760 "GalNAc is transferred onto 3a" is_a: GO:0008376 ! acetylgalactosaminyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -46239,6 +46362,7 @@ synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8] xref: EC:2.7.7.8 xref: MetaCyc:2.7.7.8-RXN +xref: RHEA:22096 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] @@ -46290,6 +46414,7 @@ xref: EC:1.14.11.2 xref: KEGG_REACTION:R03219 xref: MetaCyc:1.14.11.2-RXN xref: Reactome:R-HSA-1650808 "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines" +xref: RHEA:18945 is_a: GO:0019798 ! procollagen-proline dioxygenase activity is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity @@ -46346,6 +46471,8 @@ synonym: "protein-cysteine farnesyltransferase activity" EXACT [] xref: EC:2.5.1.58 xref: MetaCyc:2.5.1.58-RXN xref: Reactome:R-HSA-2530501 "FNTA:FNTB transfers FARN to GNGT1" +xref: Reactome:R-HSA-9647978 "pro-RAS proteins are farnesylated" +xref: RHEA:13345 is_a: GO:0008318 ! protein prenyltransferase activity [Term] @@ -46465,6 +46592,7 @@ xref: EC:3.5.3.15 xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN xref: Reactome:R-HSA-1183128 "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins" xref: Reactome:R-HSA-3247569 "PADI4 deiminates Histones" +xref: RHEA:18089 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18666 xsd:anyURI @@ -46494,6 +46622,8 @@ xref: EC:2.1.1.100 xref: KEGG_REACTION:R04496 xref: MetaCyc:2.1.1.100-RXN xref: Reactome:R-HSA-6788650 "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins" +xref: Reactome:R-HSA-9647977 "ICMT methylates S-Farn RAS proteins" +xref: RHEA:21672 is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity @@ -46511,6 +46641,7 @@ xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a" xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino" xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4" +xref: Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation" xref: Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor @@ -46561,6 +46692,7 @@ synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1] synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1] synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] +xref: EC:2.7.11 xref: Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2" xref: Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1" xref: Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2" @@ -46588,14 +46720,14 @@ xref: Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2" xref: Reactome:R-HSA-1549526 "Phosphorylation of SMAD2/3 by Activin:Activin Receptor" xref: Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation" xref: Reactome:R-HSA-156678 "Activation of Cdc25C" -xref: Reactome:R-HSA-156682 "Regulation of NUDC by phosphorylation" +xref: Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC" xref: Reactome:R-HSA-156699 "Inactivation of Wee1 kinase" xref: Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation" xref: Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A" xref: Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B" xref: Reactome:R-HSA-162657 "Inactivation of Myt1 kinase" xref: Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1" -xref: Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:Beclin-1 complex" +xref: Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex" xref: Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP" xref: Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP" xref: Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres" @@ -46844,7 +46976,7 @@ xref: Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA" xref: Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A" xref: Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs" xref: Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated" -xref: Reactome:R-HSA-5672010 "Active mTORC1 phosphorylates ULK1" +xref: Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1" xref: Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1" xref: Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1" xref: Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs" @@ -46923,7 +47055,6 @@ xref: Reactome:R-HSA-6805785 "AKT phosphorylates PHF20" xref: Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter" xref: Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A" xref: Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL" -xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" xref: Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1" xref: Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2" xref: Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53" @@ -46944,6 +47075,7 @@ xref: Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B" xref: Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C" xref: Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A" xref: Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23" +xref: Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3" xref: Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2" xref: Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1" xref: Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A" @@ -46984,7 +47116,13 @@ xref: Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 xref: Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP" xref: Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex" xref: Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4" +xref: Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF" +xref: Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF" +xref: Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF" +xref: Reactome:R-HSA-9612501 "SGK phosphorylates CREB1" +xref: Reactome:R-HSA-9612509 "SGK phosphorylates SRF" xref: Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates" +xref: Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs" xref: Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT" xref: Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs" xref: Reactome:R-HSA-9620004 "RSKs autophosphorylate" @@ -46992,7 +47130,21 @@ xref: Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EG xref: Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345" xref: Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T125" xref: Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen" +xref: Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1" +xref: Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates" xref: Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2" +xref: Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA" +xref: Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4" +xref: Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates" +xref: Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)" +xref: Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs" +xref: Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181" +xref: Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants" +xref: Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer" +xref: Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17" +xref: Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL" +xref: Reactome:R-HSA-9681627 "GSK3 phosphorylates N" +xref: Reactome:R-HSA-9683664 "GSK3B phosphorylates Ncap" xref: Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9" xref: Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9" xref: Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9" @@ -47025,6 +47177,7 @@ xref: MetaCyc:2.7.11.30-RXN xref: Reactome:R-HSA-170868 "Activated type I receptor phosphorylates SMAD2/3 directly" xref: Reactome:R-HSA-198732 "STAT3 activation" xref: Reactome:R-HSA-201476 "Activated type I receptor phosphorylates R-Smad1/5/8 directly" +xref: RHEA:18673 is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway @@ -47060,7 +47213,7 @@ xref: Reactome:R-HSA-163691 "Phosphorylation of ChREBP at Serine 568 by AMPK" xref: Reactome:R-HSA-200423 "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis" xref: Reactome:R-HSA-380927 "p-AMPK phosphorylates TSC1:TSC2" xref: Reactome:R-HSA-447074 "AMPK phosphorylates Raptor in the mTORC1 complex" -xref: Reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex" +xref: Reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex" xref: Reactome:R-HSA-6805470 "AMPK phosphorylates TP53" is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: has_part GO:0016208 ! AMP binding @@ -47072,7 +47225,6 @@ namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase activity" EXACT [] -xref: EC:2.7.11 is_obsolete: true replaced_by: GO:0004674 @@ -47083,7 +47235,6 @@ namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase I activity" EXACT [] -xref: EC:2.7.11 is_obsolete: true replaced_by: GO:0004674 @@ -47173,6 +47324,7 @@ synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "STK19" RELATED [EC:2.7.11.20] xref: EC:2.7.11.20 xref: MetaCyc:2.7.11.20-RXN +xref: RHEA:21436 is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] @@ -47198,6 +47350,7 @@ xref: EC:2.7.11.18 xref: MetaCyc:2.7.11.18-RXN xref: Reactome:R-HSA-445813 "Phosphorylation of Smooth Muscle Myosin Light Chains" xref: Reactome:R-HSA-5668978 "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex" +xref: RHEA:22004 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] @@ -47325,7 +47478,7 @@ xref: Reactome:R-HSA-187520 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p2 xref: Reactome:R-HSA-187916 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21" xref: Reactome:R-HSA-187948 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2" xref: Reactome:R-HSA-187959 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)" -xref: Reactome:R-HSA-188390 "Cyclin E:Cdk2-mediated phosphorylation of Rb" +xref: Reactome:R-HSA-188390 "Cyclin E:CDK2-mediated phosphorylation of RB1" xref: Reactome:R-HSA-1912391 "NICD1 is phosphorylated by CDK8" xref: Reactome:R-HSA-2172183 "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB" xref: Reactome:R-HSA-2220971 "CDK8 phosphorylates NICD1 PEST domain mutants" @@ -47354,6 +47507,8 @@ xref: Reactome:R-HSA-69754 "Phosphorylation of proteins involved in G2/M transit xref: Reactome:R-HSA-69756 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes" xref: Reactome:R-HSA-9008412 "CDK4 phosphorylates RUNX2" xref: Reactome:R-HSA-9009282 "CDK1 phosphorylates RUNX2" +xref: Reactome:R-HSA-9624800 "CDK1 phosphorylates LBR" +xref: Reactome:R-HSA-9686521 "CDK2:CCNA phosphorylates TERF2" is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0097472 ! cyclin-dependent protein kinase activity @@ -47480,6 +47635,7 @@ synonym: "GRK5" RELATED [EC:2.7.11.16] synonym: "GRK6" RELATED [EC:2.7.11.16] synonym: "STK16" RELATED [EC:2.7.11.16] xref: EC:2.7.11.16 +xref: RHEA:12008 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] @@ -47504,6 +47660,7 @@ xref: Reactome:R-HSA-168136 "Activated JNKs phosphorylate c-JUN" xref: Reactome:R-HSA-204949 "NRIF and TRAF6 may activate JNK" xref: Reactome:R-HSA-205075 "JNK phosphorylates BIM, BAD and other targets" xref: Reactome:R-HSA-205132 "NRAGE activates JNK" +xref: Reactome:R-HSA-9673789 "Activated JNK phosphorylates c-JUN" is_a: GO:0004707 ! MAP kinase activity relationship: part_of GO:0007258 ! JUN phosphorylation @@ -47667,6 +47824,7 @@ xref: Reactome:R-HSA-6802922 "Activated MAP2Ks phosphorylate MAPKs downstream of xref: Reactome:R-HSA-6802924 "RAF is phosphorylated downstream of oncogenic RAS" xref: Reactome:R-HSA-6802927 "BRAF and RAF fusion mutant dimers are phosphorylated" xref: Reactome:R-HSA-6802941 "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF" +xref: Reactome:R-HSA-9656212 "Phosphorylation of RAF1 mutants" is_a: GO:0004672 ! protein kinase activity [Term] @@ -47687,6 +47845,7 @@ xref: Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y- xref: Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants" xref: Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants" xref: Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers" +xref: Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer" xref: Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers" xref: Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers" xref: Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers" @@ -47700,6 +47859,7 @@ xref: Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs" xref: Reactome:R-HSA-1433506 "Phosphorylation of APS" xref: Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1" xref: Reactome:R-HSA-1470009 "Phosphorylation of STATs" +xref: Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases" xref: Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR" xref: Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated" xref: Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes" @@ -47763,7 +47923,7 @@ xref: Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src" xref: Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2" xref: Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation" xref: Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs" -xref: Reactome:R-HSA-2197698 "Phosphorylation of WASP/N-WASP" +xref: Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP" xref: Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK" xref: Reactome:R-HSA-2395412 "Phosphorylation of SYK" xref: Reactome:R-HSA-2395439 "Phosphorylation of DAP12" @@ -47988,6 +48148,7 @@ xref: Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2" xref: Reactome:R-HSA-909732 "Phosphorylation of STAT2" xref: Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated" xref: Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation" +xref: Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates" xref: Reactome:R-HSA-9606159 "BTK autophosphorylates" xref: Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2" xref: Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK" @@ -47995,6 +48156,28 @@ xref: Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDAR xref: Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates" xref: Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates" xref: Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR" +xref: Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1" +xref: Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK" +xref: Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers" +xref: Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect" +xref: Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate" +xref: Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1" +xref: Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1" +xref: Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate" +xref: Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1" +xref: Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1" +xref: Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1" +xref: Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate" +xref: Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3" +xref: Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants" +xref: Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants" +xref: Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants" +xref: Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants" +xref: Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers" +xref: Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers" +xref: Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins" +xref: Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB" +xref: Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants" xref: Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR" xref: Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)" xref: Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR" @@ -48067,6 +48250,7 @@ xref: Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylat xref: Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3" xref: Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" xref: Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3" +xref: RHEA:10596 is_a: GO:0004713 ! protein tyrosine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity @@ -48149,6 +48333,7 @@ synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase act xref: EC:2.1.1.77 xref: MetaCyc:2.1.1.77-RXN xref: Reactome:R-HSA-5676966 "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp" +xref: RHEA:12705 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity @@ -48165,6 +48350,7 @@ xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN xref: Reactome:R-HSA-2002466 "Formation of allysine by LOX" xref: Reactome:R-HSA-2129375 "Elastin cross-linking by lysyl oxidase" xref: Reactome:R-HSA-2395340 "Formation of hydroxyallysine by LOX" +xref: RHEA:24544 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -48194,6 +48380,7 @@ xref: Reactome:R-HSA-174124 "Dephosphorylation of phospho-Cdh1" xref: Reactome:R-HSA-178178 "PP1 dephosphorylates TGFBR1" xref: Reactome:R-HSA-2529015 "Dephosphorylation of CK2-modified condensin I" xref: Reactome:R-HSA-69199 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A" +xref: Reactome:R-HSA-9636684 "ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP" is_a: GO:0016791 ! phosphatase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006470 ! protein dephosphorylation @@ -48272,12 +48459,15 @@ xref: Reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH" xref: Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24" xref: Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2" xref: Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma" -xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" xref: Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO" xref: Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5" xref: Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4" xref: Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII" xref: Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1" +xref: Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs" +xref: Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex" +xref: Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs" +xref: Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] @@ -48344,13 +48534,17 @@ xref: Reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1148 (Y1172)" xref: Reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021" xref: Reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248" xref: Reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15" +xref: Reactome:R-HSA-8867658 "PTPN3 dephosphorylates MAPK12" xref: Reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1" xref: Reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB" xref: Reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3" +xref: Reactome:R-HSA-9635461 "PtpA dephosphorylates GSK3A" +xref: Reactome:R-HSA-9636439 "PtpA:Ub dephosphorylates p-Y133-VPS33B" xref: Reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2" xref: Reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B" xref: Reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1" xref: Reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP" +xref: RHEA:10684 is_a: GO:0004721 ! phosphoprotein phosphatase activity relationship: part_of GO:0035335 ! peptidyl-tyrosine dephosphorylation @@ -48363,6 +48557,7 @@ xref: Reactome:R-HSA-177923 "Sustained activation of SRC kinase by SHP2" xref: Reactome:R-HSA-177924 "Dephosphorylation of Gab1 by SHP2" xref: Reactome:R-HSA-177926 "Dephosphorylation of PAG by SHP2" xref: Reactome:R-HSA-177935 "SHP2 dephosphorylates Tyr 992 on EGFR" +xref: Reactome:R-HSA-9635739 "PTPN7 dephosphorylates p-T,Y-MAPKs" is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] @@ -48487,6 +48682,7 @@ synonym: "PDA synthase activity" EXACT [EC:1.5.4.1] synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1] xref: EC:1.5.4.1 xref: MetaCyc:1.5.4.1-RXN +xref: RHEA:10720 is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor [Term] @@ -48561,6 +48757,7 @@ synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1] synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1] synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1] xref: EC:1.2.4.1 +xref: RHEA:19189 is_a: GO:0004738 ! pyruvate dehydrogenase activity is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor @@ -48586,6 +48783,7 @@ synonym: "STK1" RELATED [EC:2.7.11.2] xref: EC:2.7.11.2 xref: MetaCyc:2.7.11.2-RXN xref: Reactome:R-HSA-203946 "PDK isoforms phosphorylate lipo-PDH" +xref: RHEA:23052 is_a: GO:0004672 ! protein kinase activity [Term] @@ -48603,6 +48801,7 @@ synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] xref: EC:3.1.3.43 xref: MetaCyc:3.1.3.43-RXN xref: Reactome:R-HSA-204169 "PDP dephosphorylates p-lipo-PDH" +xref: RHEA:12669 is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] @@ -48641,7 +48840,7 @@ synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40] xref: EC:2.7.1.40 xref: MetaCyc:PEPDEPHOS-RXN -xref: Reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP, Homo sapiens" +xref: Reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP" xref: RHEA:18159 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor relationship: part_of GO:0006096 ! glycolytic process @@ -48889,6 +49088,7 @@ xref: EC:1.1.1.153 xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN xref: Reactome:R-HSA-1475414 "PTHP is reduced to BH4 by sepiapterin reductase (SPR)" xref: Reactome:R-HSA-1497869 "Salvage - Sepiapterin is reduced to BH2" +xref: RHEA:18953 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -49022,6 +49222,7 @@ xref: EC:1.14.19.1 xref: MetaCyc:1.14.19.1-RXN xref: Reactome:R-HSA-5690565 "SCD desaturates ST-CoA to OLE-CoA" xref: Reactome:R-HSA-8847579 "SCD5 desaturates ST-CoA to OLE-CoA" +xref: RHEA:19721 is_a: GO:0016215 ! acyl-CoA desaturase activity [Term] @@ -49051,6 +49252,7 @@ xref: Reactome:R-HSA-193073 "DHA isomerizes to 4-Androstene3,17-dione" xref: Reactome:R-HSA-193961 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone" xref: Reactome:R-HSA-195690 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol" xref: Reactome:R-HSA-6807052 "EBP isomerizes ZYMSTNL to LTHSOL" +xref: RHEA:14709 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] @@ -49075,6 +49277,7 @@ xref: MetaCyc:STEROL-ESTERASE-RXN xref: Reactome:R-HSA-192417 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)" xref: Reactome:R-HSA-6813720 "NCEH1 hydrolyzes cholesterol esters" xref: Reactome:R-HSA-8865667 "LIPA hydrolyses sterol esters to sterols and fatty acids" +xref: RHEA:10100 is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity @@ -49167,7 +49370,7 @@ id: GO:0004777 name: succinate-semialdehyde dehydrogenase (NAD+) activity namespace: molecular_function alt_id: GO:0008952 -def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24] +def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [RHEA:13217] synonym: "succinate semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24] synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinate-semialdehyde dehydrogenase activity" BROAD [GOC:bf] @@ -49176,7 +49379,7 @@ synonym: "succinic semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24] synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] xref: EC:1.2.1.24 xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN -xref: Reactome:R-HSA-888548 "Conversion of succinate semialdehyde to succinate" +xref: Reactome:R-HSA-888548 "ALDH5A1 dehydrogenates SUCCSA to SUCCA" xref: RHEA:13217 is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity @@ -49258,7 +49461,8 @@ synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulphinoalanine decarboxylase activity" EXACT [] xref: EC:4.1.1.29 xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN -xref: Reactome:R-HSA-1655443 "CSAD decarboxylates 3-sulfinoalanine to hypotaurine" +xref: Reactome:R-HSA-1655443 "PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine" +xref: RHEA:16877 is_a: GO:0016831 ! carboxy-lyase activity [Term] @@ -49624,6 +49828,7 @@ xref: Reactome:R-HSA-163741 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phos xref: Reactome:R-HSA-163751 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate" xref: Reactome:R-HSA-71324 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate" xref: Reactome:R-HSA-71335 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate" +xref: RHEA:10508 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] @@ -49740,6 +49945,7 @@ synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity xref: EC:2.1.1.61 xref: KEGG_REACTION:R00601 xref: MetaCyc:2.1.1.61-RXN +xref: RHEA:19569 is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity @@ -49907,6 +50113,7 @@ xref: EC:6.1.1.16 xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-379887 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate" xref: Reactome:R-HSA-380158 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate" +xref: RHEA:17773 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] @@ -50038,6 +50245,7 @@ xref: EC:6.1.1.6 xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN xref: Reactome:R-HSA-380008 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate" xref: Reactome:R-HSA-380233 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate" +xref: RHEA:20792 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] @@ -50263,6 +50471,7 @@ synonym: "tubulinyl-tyrosine ligase activity" EXACT [] xref: EC:6.3.2.25 xref: MetaCyc:6.3.2.25-RXN xref: Reactome:R-HSA-8955706 "TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin" +xref: RHEA:17605 is_a: GO:0016881 ! acid-amino acid ligase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -50311,6 +50520,7 @@ xref: EC:2.6.1.5 xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN xref: Reactome:R-HSA-517444 "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate" xref: Reactome:R-HSA-71155 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate" +xref: RHEA:15093 is_a: GO:0070547 ! L-tyrosine aminotransferase activity [Term] @@ -50455,7 +50665,9 @@ xref: Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and xref: Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2" xref: Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains" xref: Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation" -xref: Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation" +xref: Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation" +xref: Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer" +xref: Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex" xref: Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane" xref: Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2" xref: Reactome:R-HSA-983153 "E1 mediated ubiquitin activation" @@ -50467,35 +50679,87 @@ relationship: part_of GO:0016567 ! protein ubiquitination id: GO:0004843 name: thiol-dependent ubiquitin-specific protease activity namespace: molecular_function +alt_id: GO:0036459 def: "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein." [GOC:jh2, ISBN:0120793709] synonym: "deubiquitinase" EXACT [GOC:vw, PMID:19261746] synonym: "deubiquitinase activity" NARROW [GOC:bf] synonym: "deubiquitinating enzyme" NARROW [PMID:19188440] synonym: "deubiquitylase" EXACT [GOC:vw, PMID:15657442] -synonym: "ubiquitin C-terminal hydrolase activity" EXACT [EC:3.4.19.12] +synonym: "thiol-dependent ubiquitinyl hydrolase activity" EXACT [] +synonym: "ubiquitin C-terminal hydrolase" EXACT [EC:3.4.19.12] synonym: "ubiquitin hydrolase activity" BROAD [GOC:rl] synonym: "ubiquitin-specific protease activity" BROAD [] +synonym: "ubiquitinyl hydrolase 1 activity" NARROW [] +synonym: "ubiquitinyl hydrolase activity" BROAD [] synonym: "UBP" NARROW [] synonym: "UCH2" NARROW [] +xref: EC:3.4.19.12 xref: Reactome:R-HSA-1358795 "Deubiquitination of RNF41 by P-USP8" xref: Reactome:R-HSA-2179291 "UCHL5, USP15 deubiquitinate TGFBR1" xref: Reactome:R-HSA-3215295 "USP7 deubiquitinates MDM2" xref: Reactome:R-HSA-3215310 "USP7 deubiquitinates TP53 and counteracts MDM2" +xref: Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2" xref: Reactome:R-HSA-4641236 "USP8 deubiquitinates FZD to potentiate WNT signaling" xref: Reactome:R-HSA-5653770 "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA" xref: Reactome:R-HSA-5655466 "USP1:WDR48 deubiquitinates monoUb:K164-PCNA" +xref: Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains" +xref: Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2" +xref: Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN" +xref: Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4" +xref: Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53" +xref: Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B" +xref: Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin" +xref: Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A" +xref: Reactome:R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58" +xref: Reactome:R-HSA-5690196 "USP8 deubiquitinates RNF128" +xref: Reactome:R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts" +xref: Reactome:R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1" +xref: Reactome:R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex" +xref: Reactome:R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A" xref: Reactome:R-HSA-5696465 "USP45 deubiquitinates ERCC1" +xref: Reactome:R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1" +xref: Reactome:R-HSA-5696564 "USP25 deubiquitinates DDX58" +xref: Reactome:R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1" +xref: Reactome:R-HSA-5696605 "USP12, USP26 deubiquitinate AR" +xref: Reactome:R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG" +xref: Reactome:R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins" +xref: Reactome:R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC" +xref: Reactome:R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB" +xref: Reactome:R-HSA-5696947 "USP47 deubiquitinates POLB" +xref: Reactome:R-HSA-5696958 "USP44 deubiquitinates CDC20" +xref: Reactome:R-HSA-5696960 "USP49 deubiquitinates H2B" +xref: Reactome:R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2" +xref: Reactome:R-HSA-5696997 "USP24 deubiquitinates DDB2" +xref: Reactome:R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2" +xref: Reactome:R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1" +xref: Reactome:R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10" +xref: Reactome:R-HSA-6781814 "USP19 deubiquitinates RNF123" +xref: Reactome:R-HSA-6781897 "USP11 deubiquitinates NFKBIA" xref: Reactome:R-HSA-6782069 "UVSSA:USP7 deubiquitinates ERCC6" +xref: Reactome:R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR" +xref: Reactome:R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS" +xref: Reactome:R-HSA-6782820 "USP17 deubiquitinates SUDS3" +xref: Reactome:R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33" xref: Reactome:R-HSA-6786171 "FANCD2 deubiquitination by USP1:WDR48" xref: Reactome:R-HSA-6807118 "USP7 deubiquitinates monoubiquitinated PTEN" xref: Reactome:R-HSA-6807206 "USP13 and OTUD3 deubiquitinate PTEN" +xref: Reactome:R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4" xref: Reactome:R-HSA-8853503 "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin" xref: Reactome:R-HSA-8853514 "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin" xref: Reactome:R-HSA-8853515 "OTULIN,USP5 cleaves UBC yielding ubiquitin" xref: Reactome:R-HSA-8853529 "OTULIN,USP5 cleaves UBB yielding ubiquitin" +xref: Reactome:R-HSA-8862184 "USP48 cleaves polyubiquitin" +xref: Reactome:R-HSA-8865182 "OTUD7A hydrolyses K11diUb" +xref: Reactome:R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6" +xref: Reactome:R-HSA-8873946 "OTUD3 deubiquitinates PTEN" xref: Reactome:R-HSA-8875443 "USP8 deubiquitinates LRIG1" xref: Reactome:R-HSA-8986083 "USP33 deubiquitinates ROBO1" -is_a: GO:0036459 ! thiol-dependent ubiquitinyl hydrolase activity +xref: Reactome:R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin" +xref: Reactome:R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin" +xref: Reactome:R-HSA-9653514 "USP17L2 deubiquitinates RCE1" +is_a: GO:0008242 ! omega peptidase activity +is_a: GO:0101005 ! ubiquitinyl hydrolase activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19723 xsd:anyURI [Term] id: GO:0004844 @@ -50632,6 +50896,7 @@ synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107] xref: EC:2.1.1.107 xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN +xref: RHEA:32459 is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity @@ -50685,6 +50950,7 @@ synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] xref: EC:1.17.1.4 xref: MetaCyc:RXN0-901 +xref: RHEA:16669 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] @@ -50771,6 +51037,7 @@ synonym: "cyclin dependent kinase inhibitor" RELATED [] synonym: "cyclin dependent protein kinase inhibitor activity" EXACT [] synonym: "cyclin-dependent kinase inhibitor" RELATED [] synonym: "cyclin-dependent protein kinase inhibitor activity" BROAD [] +xref: Reactome:R-HSA-187934 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21" xref: Reactome:R-HSA-69562 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21" is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity @@ -50950,7 +51217,7 @@ alt_id: GO:0008434 alt_id: GO:0038050 alt_id: GO:0038051 alt_id: GO:0038052 -def: "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] +def: "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH-2018] comment: GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'nuclear receptor transcription coactivator activity ; GO:0030374'. synonym: "1,25-(OH)2D3 receptor activity" NARROW [Wikipedia:Calcitriol] synonym: "9-cis retinoic acid receptor activity" NARROW [] @@ -51136,7 +51403,7 @@ relationship: has_part GO:0019961 ! interferon binding id: GO:0004905 name: type I interferon receptor activity namespace: molecular_function -def: "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834, PR:000025848] +def: "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon-alpha receptor activity" NARROW [] synonym: "interferon-alpha/beta receptor activity" NARROW [] synonym: "interferon-beta receptor activity" NARROW [] @@ -51698,8 +51965,8 @@ synonym: "GABA-B receptor activity" RELATED [GOC:bf] synonym: "metabotropic GABA receptor" RELATED [Wikipedia:GABAB_receptor] xref: Reactome:R-HSA-1013012 "Binding of Gbeta/gamma to GIRK/Kir3 channels" xref: Reactome:R-HSA-1013013 "Association of GABA B receptor with G protein beta-gamma subunits" +is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016917 ! GABA receptor activity -is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0004966 @@ -51734,7 +52001,6 @@ name: histamine receptor activity namespace: molecular_function def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0008227 ! G protein-coupled amine receptor activity -is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity relationship: has_part GO:0051381 ! histamine binding [Term] @@ -51818,7 +52084,6 @@ synonym: "mu-opioid receptor activity" RELATED [GOC:bf] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0004985 ! opioid receptor activity is_a: GO:0008188 ! neuropeptide receptor activity -is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity relationship: has_part GO:0031626 ! beta-endorphin binding [Term] @@ -51906,7 +52171,6 @@ name: octopamine receptor activity namespace: molecular_function def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [GOC:ai] is_a: GO:0008227 ! G protein-coupled amine receptor activity -is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0004990 @@ -51943,7 +52207,6 @@ synonym: "G protein coupled serotonin receptor activity" EXACT [] synonym: "G-protein coupled serotonin receptor activity" EXACT [] xref: Wikipedia:5-HT_receptor is_a: GO:0008227 ! G protein-coupled amine receptor activity -is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity is_a: GO:0099589 ! serotonin receptor activity relationship: has_part GO:0051378 ! serotonin binding relationship: part_of GO:0098664 ! G protein-coupled serotonin receptor signaling pathway @@ -52318,7 +52581,7 @@ consider: GO:0042614 id: GO:0005030 name: neurotrophin receptor activity namespace: molecular_function -def: "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling, http://www.mercksource.com/] +def: "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling] is_a: GO:0038023 ! signaling receptor activity relationship: has_part GO:0043121 ! neurotrophin binding relationship: part_of GO:0038179 ! neurotrophin signaling pathway @@ -52781,7 +53044,7 @@ xref: Reactome:R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity" xref: Reactome:R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1" xref: Reactome:R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1" xref: Reactome:R-HSA-187746 "RIT/RIN are activated" -xref: Reactome:R-HSA-2029445 "Activation of CDC42 by unknown mechanism" +xref: Reactome:R-HSA-2029445 "An unknown GEF exchanges GTP for GDP on CDC42:GDP" xref: Reactome:R-HSA-2029451 "Activation of RAC1 by VAV" xref: Reactome:R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO" xref: Reactome:R-HSA-203977 "SAR1 Activation And Membrane Binding" @@ -52836,6 +53099,11 @@ xref: Reactome:R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated" xref: Reactome:R-HSA-8982637 "Opsins binds G alpha-t" xref: Reactome:R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)" xref: Reactome:R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs" +xref: Reactome:R-HSA-9639286 "RRAGC,D exchanges GTP for GDP" +xref: Reactome:R-HSA-9640167 "RRAGA,B exchanges GDP for GTP" +xref: Reactome:R-HSA-9660824 "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs" +xref: Reactome:R-HSA-9666428 "DOCK180 exchanges GTP for GDP on RAC1:GDP" +xref: Reactome:R-HSA-9666430 "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP" is_a: GO:0051020 ! GTPase binding is_a: GO:0098772 ! molecular function regulator @@ -52857,6 +53125,7 @@ namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "RCC1" EXACT [] xref: Reactome:R-HSA-180687 "Conversion of Ran-GDP to Ran-GTP" +xref: Reactome:R-HSA-9624845 "RCC1 stimulates GDP to GTP exchange on RAN" xref: Wikipedia:RCC1 is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity is_a: GO:0008536 ! Ran GTPase binding @@ -52877,7 +53146,7 @@ xref: Reactome:R-HSA-1306972 "RAS guanyl nucleotide exchange mediated by SOS1 bo xref: Reactome:R-HSA-1433471 "Activation of RAS by p-KIT bound SOS1" xref: Reactome:R-HSA-177938 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)" xref: Reactome:R-HSA-177945 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)" -xref: Reactome:R-HSA-186834 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)" +xref: Reactome:R-HSA-186834 "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)" xref: Reactome:R-HSA-210977 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)" xref: Reactome:R-HSA-2179407 "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)" xref: Reactome:R-HSA-2424477 "SOS mediated nucleotide exchange of RAS (SHC)" @@ -52904,6 +53173,17 @@ xref: Reactome:R-HSA-8853307 "FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucle xref: Reactome:R-HSA-9026891 "NTRK2 activates RAS signaling through SHC1" xref: Reactome:R-HSA-9029158 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS" xref: Reactome:R-HSA-9032067 "NTRK2 activates RAS signaling through FRS2" +xref: Reactome:R-HSA-9607304 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)" +xref: Reactome:R-HSA-9634418 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1" +xref: Reactome:R-HSA-9664991 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants" +xref: Reactome:R-HSA-9665009 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR" +xref: Reactome:R-HSA-9665404 "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1" +xref: Reactome:R-HSA-9665408 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2" +xref: Reactome:R-HSA-9665700 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants" +xref: Reactome:R-HSA-9665707 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR" +xref: Reactome:R-HSA-9670436 "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS" +xref: Reactome:R-HSA-9672163 "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers" +xref: Reactome:R-HSA-9672170 "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors" is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity is_a: GO:0017016 ! Ras GTPase binding @@ -53020,6 +53300,7 @@ xref: Reactome:R-HSA-428522 "Inactivation of RAC1" xref: Reactome:R-HSA-428533 "Inactivation of CDC42" xref: Reactome:R-HSA-5638007 "RP2 activates the GTPase activity of ARL3" xref: Reactome:R-HSA-8985594 "MYO9B inactivates RHOA" +xref: Reactome:R-HSA-9624893 "RAN stimulates fusion of nuclear envelope (NE) membranes" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0030695 ! GTPase regulator activity relationship: part_of GO:0043547 ! positive regulation of GTPase activity @@ -53107,7 +53388,7 @@ id: GO:0005109 name: frizzled binding namespace: molecular_function alt_id: GO:0005110 -def: "Interacting selectively and non-covalently with a frizzled (fz) receptor." [GOC:ceb, PR:000001315] +def: "Interacting selectively and non-covalently with a frizzled (fz) receptor." [GOC:ceb] subset: goslim_chembl synonym: "frizzled ligand" NARROW [] synonym: "frizzled-2 binding" NARROW [] @@ -53641,7 +53922,6 @@ synonym: "transforming growth factor beta ligand binding to type I receptor" REL synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor anchoring activity" RELATED [] synonym: "transforming growth factor beta receptor ligand" NARROW [] -xref: Reactome:R-HSA-170861 "Dimeric TGF-beta-1 binds to the receptor" is_a: GO:0005126 ! cytokine receptor binding [Term] @@ -54267,6 +54547,7 @@ def: "Enables the transmembrane transfer of chloride by a channel that opens in xref: Reactome:R-HSA-2684901 "ANOs transport cytosolic Cl- to extracellular region" xref: Reactome:R-HSA-2744242 "TTYH2/3 transport cytosolic Cl- to extracellular region" xref: Reactome:R-HSA-2744361 "BESTs transport cytosolic Cl- to extracellular region" +xref: Reactome:R-HSA-9659568 "ANO1 transports cytosolic Cl- to extracellular region" is_a: GO:0022839 ! ion gated channel activity is_a: GO:0061778 ! intracellular chloride channel activity @@ -54439,7 +54720,7 @@ id: GO:0005250 name: A-type (transient outward) potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340] -xref: Reactome:R-HSA-5577234 "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extrqcellular region" +xref: Reactome:R-HSA-5577234 "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region" is_a: GO:0015271 ! outward rectifier potassium channel activity [Term] @@ -54466,6 +54747,7 @@ def: "Enables the energy-independent passage of anions across a lipid bilayer do synonym: "non-selective anion channel activity" NARROW [] xref: Reactome:R-HSA-432034 "Aquaporin-6 passively transports anions into vesicles" xref: Reactome:R-HSA-432036 "Aquaporin-6 passively transports anions out of vesicles" +xref: RHEA:34923 is_a: GO:0005216 ! ion channel activity is_a: GO:0015103 ! inorganic anion transmembrane transporter activity disjoint_from: GO:0005261 ! cation channel activity @@ -54478,7 +54760,7 @@ def: "Enables the facilitated diffusion of a chloride (by an energy-independent xref: Reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region" xref: Reactome:R-HSA-427570 "Group 3 - Selective Cl- transport" xref: Reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol" -xref: Reactome:R-HSA-975449 "GABRR pentamer:GABA transports extracellular Cl- to cytosol" +xref: Reactome:R-HSA-975449 "GABRR pentamers:GABA transports extracellular Cl- to cytosol" is_a: GO:0005253 ! anion channel activity is_a: GO:0015108 ! chloride transmembrane transporter activity @@ -54527,7 +54809,6 @@ xref: Reactome:R-HSA-139854 "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ fro xref: Reactome:R-HSA-139855 "P2X1-mediated entry of Ca++ from plasma" xref: Reactome:R-HSA-210420 "Ca2+ influx through voltage gated Ca2+ channels" xref: Reactome:R-HSA-3295579 "TRPs transport extracellular Ca2+ to cytosol" -xref: Reactome:R-HSA-5263618 "CACFD1 dimer transports Ca2+ from extracellular region to cytosol" xref: Reactome:R-HSA-8949145 "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space" xref: Reactome:R-HSA-8949178 "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix" is_a: GO:0005261 ! cation channel activity @@ -54539,7 +54820,7 @@ name: potassium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: Reactome:R-HSA-1296024 "Activation of ATP sensitive Potassium channels in neuroendocrine cells" -xref: Reactome:R-HSA-1296035 "Activation of Ca2+ activated Potassium channels with Intermeidtance conductance" +xref: Reactome:R-HSA-1296035 "Activation of Ca2+ activated Potassium channels with Intermediate conductance" xref: Reactome:R-HSA-1296037 "Activation of Ca2+ activated Potassium channels with large conductance" xref: Reactome:R-HSA-1296039 "Activation of Ca2+ activated Potassium channels with small conductance" xref: Reactome:R-HSA-1296348 "Activation of TWIK-related K+ channel (TREK)" @@ -54558,7 +54839,7 @@ id: GO:0005272 name: sodium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] -xref: Reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports cytosolic Na+ to extracellular region" +xref: Reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol" xref: Reactome:R-HSA-3295580 "TRPM4,5 transport extracellular Na+ to cytosol" is_a: GO:0005261 ! cation channel activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity @@ -54603,7 +54884,7 @@ id: GO:0005277 name: acetylcholine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] -xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicle" +xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles" is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:1901375 ! acetate ester transmembrane transporter activity @@ -54811,8 +55092,8 @@ name: choline:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5] synonym: "sodium/choline symporter activity" EXACT [] -is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015220 ! choline transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005308 @@ -54820,7 +55101,6 @@ name: creatine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity relationship: part_of GO:0015881 ! creatine transmembrane transport @@ -54875,7 +55155,6 @@ xref: Reactome:R-HSA-210444 "L-Glutamate loading of synaptic vesicle" xref: Reactome:R-HSA-428052 "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+" xref: Reactome:R-HSA-5624256 "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity -is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015813 ! L-glutamate transmembrane transport @@ -54891,7 +55170,6 @@ xref: Reactome:R-HSA-428015 "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na xref: Reactome:R-HSA-5625015 "Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5625029 "SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol" is_a: GO:0005313 ! L-glutamate transmembrane transporter activity -is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015501 ! glutamate:sodium symporter activity [Term] @@ -55060,7 +55338,6 @@ synonym: "GABA:sodium symporter activity" EXACT [] synonym: "sodium/chloride-dependent GABA transporter activity" BROAD [] xref: Reactome:R-HSA-444007 "GAT1-3 mediate Na+/Cl- dependent GABA transport" is_a: GO:0005283 ! amino acid:sodium symporter activity -is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity is_a: GO:0140161 ! monocarboxylate:sodium symporter activity @@ -55095,8 +55372,9 @@ synonym: "serotonin transmembrane transporter activity" EXACT [] synonym: "serotonin:sodium:chloride symporter activity" EXACT [] synonym: "sodium/serotonin symporter activity" EXACT [] xref: Reactome:R-HSA-444008 "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol" -is_a: GO:0005328 ! neurotransmitter:sodium symporter activity +xref: RHEA:51196 is_a: GO:0008504 ! monoamine transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015378 ! sodium:chloride symporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0051610 ! serotonin uptake @@ -55116,6 +55394,7 @@ xref: Reactome:R-HSA-727740 "Equilibrative transport (import) of adenosine and b xref: Reactome:R-HSA-727749 "SLC29A3 transports nucleosides from lysosomal lumen to cytosol" xref: Reactome:R-HSA-727767 "SLC29A3 transports nucleosides from cytosol to lysosomal lumen" xref: Reactome:R-HSA-727768 "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4" +xref: RHEA:27318 is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:1901642 ! nucleoside transmembrane transport @@ -55387,6 +55666,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "hydrogen/myo-inositol transporter activity" BROAD [] synonym: "myo-inositol:hydrogen symporter activity" EXACT [] xref: Reactome:R-HSA-429101 "HMIT co-transports myo-inositol with a proton" +xref: RHEA:60364 is_a: GO:0005365 ! myo-inositol transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity @@ -55510,6 +55790,7 @@ xref: Reactome:R-HSA-5623558 "Defective SLC11A2 does not cotransport Fe2+, H+ fr xref: Reactome:R-HSA-5655733 "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region" xref: Reactome:R-HSA-904830 "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region" xref: Reactome:R-HSA-917936 "MCOLN1 transports Fe2+ from endosome lumen to cytosol" +xref: RHEA:29579 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0034755 ! iron ion transmembrane transport property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17162 xsd:anyURI @@ -55520,6 +55801,7 @@ name: manganese ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf] xref: Reactome:R-HSA-8959798 "SLC30A10 transports Mn2+ from cytosol to extracellular region" +xref: RHEA:28699 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0071421 ! manganese ion transmembrane transport @@ -55595,7 +55877,7 @@ synonym: "sodium/potassium-transporting ATPase activity" EXACT [] synonym: "sodium:potassium exchanging ATPase activity" EXACT [] xref: EC:7.2.2.13 xref: MetaCyc:3.6.3.9-RXN -xref: Reactome:R-HSA-936897 "ATP1A:ATP1B:FXYD exchanges Na+ for K+" +xref: Reactome:R-HSA-936897 "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+" xref: RHEA:18353 is_a: GO:0008554 ! sodium transmembrane transporter activity, phosphorylative mechanism is_a: GO:0008556 ! potassium transmembrane transporter activity, phosphorylative mechanism @@ -55607,9 +55889,6 @@ name: obsolete eye pigment precursor transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1] comment: This term has been obsoleted because eye pigment precursors are nucleotides and amino acids, and there are terms to annotate these functions. -xref: Reactome:R-HSA-1467466 "ABCA4 mediates atRAL transport" -xref: Reactome:R-HSA-2466749 "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol" -xref: Reactome:R-HSA-2466802 "Defective ABCA4 does not transport NRPE from disc membranes" is_obsolete: true [Term] @@ -55720,6 +55999,7 @@ synonym: "sodium:calcium exchange" RELATED [] xref: Reactome:R-HSA-425661 "SLC8A1,2,3 exchange 3Na+ for Ca2+" xref: Reactome:R-HSA-8949688 "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)" xref: Reactome:R-HSA-8949703 "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)" +xref: RHEA:29255 is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015368 ! calcium:cation antiporter activity @@ -55732,6 +56012,15 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "sodium-dependent phosphate transmembrane transporter activity" RELATED [] synonym: "sodium/phosphate symporter activity" EXACT [] xref: Reactome:R-HSA-2872498 "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol" +xref: Reactome:R-HSA-427605 "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-427645 "SLC34A3 cotransports Pi, 2Na+" +xref: Reactome:R-HSA-427656 "SLC34A1,2 cotransports HPO4(2-), 3Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-428609 "Type I Na+-coupled phosphate co-transport" +xref: Reactome:R-HSA-5625123 "Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5651685 "Defective SLC34A1 does not cotransport Pi, 3Na+" +xref: Reactome:R-HSA-5651697 "Defective SLC34A2 does not cotransport Pi, 3Na+" +xref: Reactome:R-HSA-5651971 "Defective SLC34A3 does not cotransport Pi, 2Na+" +xref: Reactome:R-HSA-5687585 "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol" is_a: GO:0015370 ! solute:sodium symporter activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18577 xsd:anyURI @@ -56191,8 +56480,6 @@ subset: goslim_pir subset: goslim_plant synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] -xref: Reactome:R-HSA-170835 "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3" -xref: Reactome:R-HSA-170846 "TGFBR2 recruits TGFBR1" is_a: GO:0005488 ! binding [Term] @@ -56264,7 +56551,6 @@ name: ATP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] xref: Reactome:R-HSA-265682 "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel" -is_a: GO:0008144 ! drug binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding @@ -56294,6 +56580,7 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED [] is_a: GO:0005527 ! macrolide binding +is_a: GO:0033218 ! amide binding [Term] id: GO:0005530 @@ -56401,7 +56688,6 @@ def: "Interacting selectively and non-covalently with folic acid, pteroylglutami synonym: "folate binding" EXACT [] synonym: "vitamin B9 binding" EXACT [] synonym: "vitamin M binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0033218 ! amide binding @@ -57120,16 +57406,14 @@ is_a: GO:0005575 ! cellular_component [Term] id: GO:0005623 -name: cell +name: obsolete cell namespace: cellular_component -def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] -subset: goslim_chembl -subset: goslim_generic -subset: goslim_plant +def: "OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] +comment: This term was obsoleted because it was redundant with the root class of the cell ontology, CL:0000000. xref: NIF_Subcellular:sao1813327414 xref: Wikipedia:Cell_(biology) -is_a: GO:0005575 ! cellular_component property_value: IAO:0000589 "cell and encapsulating structures" xsd:string +is_obsolete: true [Term] id: GO:0005624 @@ -61175,7 +61459,6 @@ synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT [] synonym: "chitin metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:1901071 ! glucosamine-containing compound metabolic process [Term] @@ -61205,7 +61488,6 @@ synonym: "chitin catabolism" EXACT [] synonym: "chitin degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0006030 ! chitin metabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901072 ! glucosamine-containing compound catabolic process [Term] @@ -61447,8 +61729,9 @@ synonym: "N-acetylneuraminate metabolism" EXACT [] synonym: "sialic acid metabolic process" BROAD [] synonym: "sialic acid metabolism" BROAD [] is_a: GO:0006040 ! amino sugar metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006055 @@ -61589,7 +61872,6 @@ name: ethanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] synonym: "ethanol metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0034308 ! primary alcohol metabolic process [Term] @@ -61601,9 +61883,7 @@ synonym: "ethanol breakdown" EXACT [] synonym: "ethanol catabolism" EXACT [] synonym: "ethanol degradation" EXACT [] is_a: GO:0006067 ! ethanol metabolic process -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0034310 ! primary alcohol catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006069 @@ -61777,7 +62057,6 @@ name: acetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators] synonym: "acetate metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] @@ -61975,7 +62254,6 @@ name: citrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] synonym: "citrate metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] @@ -62015,7 +62293,6 @@ name: succinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732] synonym: "succinate metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] @@ -62127,7 +62404,6 @@ synonym: "ethanol biosynthesis" EXACT [] synonym: "ethanol formation" EXACT [] synonym: "ethanol synthesis" EXACT [] is_a: GO:0006067 ! ethanol metabolic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] @@ -62194,7 +62470,7 @@ relationship: has_part GO:0015986 ! ATP synthesis coupled proton transport id: GO:0006120 name: mitochondrial electron transport, NADH to ubiquinone namespace: biological_process -def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] +def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363] synonym: "complex I (NADH to ubiquinone)" RELATED [] synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT [] is_a: GO:0022904 ! respiratory electron transport chain @@ -62557,7 +62833,6 @@ synonym: "adenosine breakdown" EXACT [] synonym: "adenosine catabolism" EXACT [] synonym: "adenosine degradation" EXACT [] synonym: "adenosine phosphorolysis" RELATED [] -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046085 ! adenosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process @@ -63005,7 +63280,6 @@ synonym: "AMP catabolism" EXACT [] synonym: "AMP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046033 ! AMP metabolic process [Term] @@ -63200,7 +63474,6 @@ synonym: "uracil catabolism" EXACT [] synonym: "uracil degradation" EXACT [] is_a: GO:0006208 ! pyrimidine nucleobase catabolic process is_a: GO:0019860 ! uracil metabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006213 @@ -66495,8 +66768,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process -is_a: GO:0017144 ! drug metabolic process -is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0006545 @@ -66510,7 +66781,6 @@ synonym: "glycine synthesis" EXACT [] xref: MetaCyc:GLYCINE-SYN2-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process -is_a: GO:0042136 ! neurotransmitter biosynthetic process [Term] id: GO:0006546 @@ -66522,8 +66792,6 @@ synonym: "glycine catabolism" EXACT [] synonym: "glycine degradation" EXACT [] is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process -is_a: GO:0042135 ! neurotransmitter catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006547 @@ -66638,7 +66906,6 @@ synonym: "S-adenosylmethionine formation" EXACT [] synonym: "S-adenosylmethionine synthesis" EXACT [] synonym: "SAM biosynthetic process" EXACT [] xref: MetaCyc:SAM-PWY -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046500 ! S-adenosylmethionine metabolic process is_a: GO:1901576 ! organic substance biosynthetic process @@ -66666,7 +66933,6 @@ synonym: "L-phenylalanine metabolism" EXACT [] synonym: "phenylalanine metabolic process" BROAD [] synonym: "phenylalanine metabolism" BROAD [] is_a: GO:0009072 ! aromatic amino acid family metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [Term] @@ -66681,7 +66947,6 @@ synonym: "phenylalanine catabolic process" BROAD [] synonym: "phenylalanine catabolism" BROAD [] is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1902222 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [Term] @@ -66945,8 +67210,6 @@ synonym: "acetylcholine catabolism" EXACT [] synonym: "acetylcholine degradation" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process -is_a: GO:0042447 ! hormone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] @@ -67136,7 +67399,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023] synonym: "creatine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] @@ -67571,7 +67833,6 @@ name: acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732] synonym: "acyl-CoA metabolism" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process @@ -67721,7 +67982,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin." [ISBN:0198506732] synonym: "1,2-diacyl-sn-glycero-3-phosphocholine metabolism" EXACT [GOC:mah] synonym: "lecithin metabolic process" BROAD [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046470 ! phosphatidylcholine metabolic process [Term] @@ -67842,6 +68102,7 @@ synonym: "platelet activating factor anabolism" EXACT [] synonym: "platelet activating factor biosynthesis" EXACT [] synonym: "platelet activating factor formation" EXACT [] synonym: "platelet activating factor synthesis" EXACT [] +is_a: GO:0008611 ! ether lipid biosynthetic process is_a: GO:0046469 ! platelet activating factor metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process @@ -68307,8 +68568,8 @@ synonym: "glucocorticoid anabolism" EXACT [] synonym: "glucocorticoid biosynthesis" EXACT [] synonym: "glucocorticoid formation" EXACT [] synonym: "glucocorticoid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008211 ! glucocorticoid metabolic process -is_a: GO:0120178 ! steroid hormone biosynthetic process [Term] id: GO:0006705 @@ -68370,7 +68631,6 @@ synonym: "progesterone degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042448 ! progesterone metabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006710 @@ -68420,7 +68680,6 @@ synonym: "glucocorticoid catabolism" EXACT [] synonym: "glucocorticoid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008211 ! glucocorticoid metabolic process -is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006714 @@ -68442,7 +68701,6 @@ synonym: "farnesol synthesis" EXACT [] is_a: GO:0016094 ! polyprenol biosynthetic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0016487 ! farnesol metabolic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] @@ -68596,7 +68854,6 @@ synonym: "tetrahydrobiopterin anabolism" EXACT [] synonym: "tetrahydrobiopterin biosynthesis" EXACT [] synonym: "tetrahydrobiopterin formation" EXACT [] synonym: "tetrahydrobiopterin synthesis" EXACT [] -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0046146 ! tetrahydrobiopterin metabolic process @@ -68626,29 +68883,30 @@ def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and pros comment: This term was made obsolete because it was replaced by more specific terms. synonym: "coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true -consider: GO:0006732 consider: GO:0051189 [Term] id: GO:0006732 -name: coenzyme metabolic process +name: obsolete coenzyme metabolic process namespace: biological_process alt_id: GO:0006752 -def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] +def: "OBSOLETE. The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "coenzyme metabolism" EXACT [] synonym: "group transfer coenzyme metabolic process" NARROW [] synonym: "group transfer coenzyme metabolism" NARROW [] -is_a: GO:0051186 ! cofactor metabolic process +is_obsolete: true [Term] id: GO:0006733 -name: oxidoreduction coenzyme metabolic process +name: obsolete oxidoreduction coenzyme metabolic process namespace: biological_process -def: "The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah] +def: "OBSOLETE. The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. synonym: "oxidoreduction coenzyme metabolism" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process +is_obsolete: true [Term] id: GO:0006734 @@ -68789,7 +69047,6 @@ def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble synonym: "coenzyme Q metabolic process" EXACT [] synonym: "coenzyme Q metabolism" EXACT [] synonym: "ubiquinone metabolism" EXACT [] -is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:1901661 ! quinone metabolic process [Term] @@ -68797,6 +69054,7 @@ id: GO:0006744 name: ubiquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] +subset: goslim_pombe synonym: "coenzyme Q biosynthesis" EXACT [] synonym: "coenzyme Q biosynthetic process" EXACT [] synonym: "coenzyme Q10 biosynthesis" NARROW [] @@ -68822,7 +69080,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide." [GOC:ai] synonym: "FADH2 metabolism" EXACT [] synonym: "reduced flavin adenine dinucleotide metabolic process" EXACT [GOC:mah] -is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process [Term] @@ -68863,7 +69120,6 @@ synonym: "oxidized glutathione reduction" NARROW [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006750 @@ -68879,7 +69135,6 @@ is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0006751 @@ -68893,7 +69148,6 @@ is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process -is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0006753 @@ -68919,7 +69173,6 @@ synonym: "ATP regeneration" NARROW [] synonym: "ATP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046034 ! ATP metabolic process [Term] @@ -68968,7 +69221,6 @@ synonym: "vitamin B9 and derivative metabolism" EXACT [] synonym: "vitamin M and derivative metabolic process" EXACT [] synonym: "vitamin M and derivative metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process @@ -69031,10 +69283,8 @@ synonym: "vitamin B7 metabolism" EXACT [] synonym: "vitamin H metabolic process" EXACT [] synonym: "vitamin H metabolism" EXACT [] xref: Wikipedia:Biotin -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process @@ -69054,9 +69304,7 @@ synonym: "vitamin B3 metabolism" BROAD [] xref: MetaCyc:PWY-5083 is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009820 ! alkaloid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0043603 ! cellular amide metabolic process -is_a: GO:0051186 ! cofactor metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] @@ -69071,7 +69319,6 @@ synonym: "vitamin G metabolic process" EXACT [] synonym: "vitamin G metabolism" EXACT [] xref: Wikipedia:Riboflavin is_a: GO:0006767 ! water-soluble vitamin metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process [Term] @@ -69128,7 +69375,6 @@ synonym: "Moco biosynthesis" EXACT [] synonym: "Moco biosynthetic process" EXACT [] synonym: "molybdenum cofactor biosynthetic process" RELATED [] xref: MetaCyc:PWY-6823 -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process @@ -69146,7 +69392,6 @@ def: "The chemical reactions and pathways involving any member of a large group synonym: "porphyrin metabolic process" RELATED [] synonym: "porphyrin metabolism" RELATED [] is_a: GO:0033013 ! tetrapyrrole metabolic process -is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006779 @@ -69160,7 +69405,6 @@ synonym: "porphyrin formation" RELATED [] synonym: "porphyrin synthesis" RELATED [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0006780 @@ -69273,7 +69517,6 @@ synonym: "porphyrin catabolism" RELATED [] synonym: "porphyrin degradation" RELATED [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process -is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0006788 @@ -69513,7 +69756,6 @@ synonym: "nitric oxide anabolism" EXACT [] synonym: "nitric oxide biosynthesis" EXACT [] synonym: "nitric oxide formation" EXACT [] synonym: "nitric oxide synthesis" EXACT [] -is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046209 ! nitric oxide metabolic process is_a: GO:1903409 ! reactive oxygen species biosynthetic process @@ -69748,8 +69990,7 @@ id: GO:0006837 name: serotonin transport namespace: biological_process def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] -is_a: GO:0006812 ! cation transport -is_a: GO:0006836 ! neurotransmitter transport +is_a: GO:0015695 ! organic cation transport is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport @@ -69814,7 +70055,6 @@ name: acyl carnitine transport namespace: biological_process def: "The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai] is_a: GO:0015697 ! quaternary ammonium group transport -is_a: GO:0051181 ! cofactor transport [Term] id: GO:0006845 @@ -70605,7 +70845,7 @@ relationship: part_of GO:0043029 ! T cell homeostasis id: GO:0006925 name: inflammatory cell apoptotic process namespace: biological_process -def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis, http://www.mercksource.com/] +def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis] synonym: "apoptosis of inflammatory cells" EXACT [] synonym: "inflammatory cell apoptosis" NARROW [] synonym: "inflammatory cell programmed cell death by apoptosis" EXACT [] @@ -72210,6 +72450,7 @@ def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a synonym: "Dma1-dependent checkpoint" NARROW [] synonym: "Mad2-dependent checkpoint" NARROW [] synonym: "mitotic cell cycle spindle assembly checkpoint" EXACT [] +synonym: "mitotic checkpoint" EXACT [] synonym: "SAC-independent checkpoint" NARROW [] is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition is_a: GO:0071173 ! spindle assembly checkpoint @@ -72544,12 +72785,13 @@ is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007129 -name: synapsis +name: homologous chromosome pairing at meiosis namespace: biological_process -def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617] +def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152] synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] -synonym: "chromosomal synapsis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "chromosomal synapsis" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "homologous chromosome pairing at meiosis" EXACT [] +synonym: "synapsis" NARROW [] xref: Wikipedia:Synapsis is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle relationship: part_of GO:0045143 ! homologous chromosome segregation @@ -72563,7 +72805,7 @@ synonym: "synaptonemal complex formation" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle is_a: GO:0070193 ! synaptonemal complex organization -relationship: part_of GO:0007129 ! synapsis +relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis [Term] id: GO:0007131 @@ -72975,7 +73217,7 @@ is_a: GO:0034622 ! cellular protein-containing complex assembly id: GO:0007173 name: epidermal growth factor receptor signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] +def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb] synonym: "EGF receptor signaling pathway" EXACT [] synonym: "EGF receptor signalling pathway" EXACT [] synonym: "EGFR signaling pathway" EXACT [] @@ -77283,7 +77525,7 @@ is_a: GO:0007632 ! visual behavior id: GO:0007634 name: optokinetic behavior namespace: biological_process -def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr, http://www.mercksource.com] +def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr] synonym: "optokinetic behaviour" EXACT [] is_a: GO:0007632 ! visual behavior @@ -77460,6 +77702,7 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] synonym: "microtubule severing activity" RELATED [] synonym: "microtubule/chromatin interaction" RELATED [] +xref: Reactome:R-HSA-9614343 "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs" is_a: GO:0015631 ! tubulin binding [Term] @@ -77574,8 +77817,9 @@ def: "Enables the transfer of monocarboxylic acids from one side of a membrane t synonym: "monocarboxylate carrier" NARROW [] synonym: "prostaglandin/thromboxane transporter activity" NARROW [] xref: Reactome:R-HSA-429749 "SLC5A8 transports monocarboxylates from extracellular region to cytosol" -xref: Reactome:R-HSA-433698 "SLC16A1,3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol" xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity relationship: part_of GO:0015718 ! monocarboxylic acid transport @@ -77840,7 +78084,6 @@ name: chitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] subset: goslim_drosophila -is_a: GO:0008144 ! drug binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] @@ -78027,6 +78270,7 @@ xref: EC:2.3.1.5 xref: Reactome:R-HSA-2468039 "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2" xref: Reactome:R-HSA-2473152 "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2" xref: Reactome:R-HSA-6790987 "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842" +xref: Reactome:R-HSA-9636560 "Eis acetylates DUSP16" is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016410 ! N-acyltransferase activity @@ -78152,10 +78396,10 @@ is_a: GO:0005515 ! protein binding id: GO:0008093 name: cytoskeletal anchor activity namespace: molecular_function -def: "The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238] +def: "The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238] synonym: "cytoskeletal adaptor activity" EXACT [] -is_a: GO:0008092 ! cytoskeletal protein binding is_a: GO:0030674 ! protein-macromolecule adaptor activity +relationship: has_part GO:0008092 ! cytoskeletal protein binding property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17668 xsd:anyURI property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19119 xsd:anyURI @@ -78237,6 +78481,7 @@ synonym: "aldehyde reductase (NADPH2) activity" EXACT [] synonym: "NADP-aldehyde reductase activity" EXACT [] xref: EC:1.1.1.2 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN +xref: RHEA:15937 is_a: GO:0004033 ! aldo-keto reductase (NADP) activity [Term] @@ -78385,6 +78630,7 @@ xref: MetaCyc:RXN-8668 xref: MetaCyc:RXN-8669 xref: Reactome:R-HSA-1222363 "MsrA/B reduces peptide-methionine S/R-sulfoxides" xref: Reactome:R-HSA-5676940 "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine" +xref: RHEA:14217 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] @@ -78587,8 +78833,6 @@ synonym: "elaszym" RELATED [EC:3.4.21.36] synonym: "pancreatic elastase I activity" EXACT [] synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36] synonym: "serine elastase" BROAD [EC:3.4.21.36] -xref: EC:3.4.21.36 -xref: MetaCyc:3.4.21.36-RXN is_obsolete: true replaced_by: GO:0004252 @@ -78605,6 +78849,7 @@ synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6] synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6] xref: EC:3.1.1.6 xref: MetaCyc:ACETYLESTERASE-RXN +xref: RHEA:12957 xref: UM-BBD_reactionID:r0170 is_a: GO:0034338 ! short-chain carboxylesterase activity @@ -78634,8 +78879,6 @@ synonym: "actinidain activity" EXACT [] synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14] synonym: "actinidin activity" EXACT [EC:3.4.22.14] synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14] -xref: EC:3.4.22.14 -xref: MetaCyc:3.4.22.14-RXN is_obsolete: true replaced_by: GO:0004197 @@ -78649,8 +78892,6 @@ synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34] synonym: "MMP-8" EXACT [] synonym: "neutrophil collagenase activity" EXACT [] synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34] -xref: EC:3.4.24.34 -xref: MetaCyc:3.4.24.34-RXN is_obsolete: true replaced_by: GO:0004252 @@ -78671,8 +78912,8 @@ xref: Reactome:R-HSA-141186 "MAOA:FAD oxidatively deaminates of 5HT" xref: Reactome:R-HSA-141200 "MAOB:FAD oxidatively deaminates of PEA" xref: Reactome:R-HSA-141202 "MAOB:FAD oxidatively deaminates TYR" xref: Reactome:R-HSA-374909 "Metabolism of Noradrenaline" -xref: Reactome:R-HSA-379382 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC)" -xref: Reactome:R-HSA-379395 "Oxidation of 3-Methoxytyramine to homovanillic acid" +xref: Reactome:R-HSA-379382 "MAOA:FAD deaminates DA to DOPAC" +xref: Reactome:R-HSA-379395 "MAOA:FAD deaminates 3MT to HVA" xref: Reactome:R-HSA-5603108 "Defective MAOA does not oxidatively deaminate 5HT" xref: Reactome:R-HSA-5696146 "AOC2 deaminates TYR" xref: Reactome:R-HSA-5696183 "AOC3 deaminates BZAM" @@ -78685,7 +78926,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71] comment: This term was made obsolete because it represents a gene product. synonym: "pancreatic elastase activity" EXACT [] -xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 @@ -78696,7 +78936,6 @@ namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "collagenase activity" EXACT [] -xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 @@ -78774,6 +79013,7 @@ comment: Note that this term applies only to free amino acids. Consider 'protein synonym: "dual-specificity protein phosphatase" BROAD [] xref: Reactome:R-HSA-5675373 "Nuclear DUSPs dephosphorylate MAPKs" xref: Reactome:R-HSA-5675376 "Cytosolic DUSPs dephosphorylate MAPKs" +xref: Reactome:R-HSA-9652816 "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs" is_a: GO:0004721 ! phosphoprotein phosphatase activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12183 xsd:anyURI @@ -78857,6 +79097,7 @@ xref: Reactome:R-HSA-176588 "lithocholate + PAPS => lithocholate sulfate + PAP" xref: Reactome:R-HSA-176604 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP" xref: Reactome:R-HSA-176669 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP" xref: Reactome:R-HSA-2022061 "Dermatan sulfate can be further sulfated on position 2 of iduronate" +xref: RHEA:51064 is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] @@ -79106,8 +79347,9 @@ subset: goslim_generic subset: goslim_yeast synonym: "methylase" BROAD [] xref: EC:2.1.1 -xref: Reactome:R-HSA-379387 "methylation of Dopamine to form 3-Methoxytyramine" -xref: Reactome:R-HSA-379464 "Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid" +xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3" +xref: Reactome:R-HSA-379387 "COMT transfers Met to DA to form 3MT" +xref: Reactome:R-HSA-379464 "COMT transfers Met to DOPAC to form HVA" xref: Reactome:R-HSA-6800149 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII" xref: Reactome:R-HSA-71286 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine" is_a: GO:0016741 ! transferase activity, transferring one-carbon groups @@ -79199,6 +79441,7 @@ synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] xref: EC:2.1.1.33 xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-6782286 "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46" +xref: RHEA:42708 is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity relationship: part_of GO:0106004 ! tRNA (guanine-N7)-methylation @@ -79525,7 +79768,6 @@ synonym: "glucocorticoid metabolism" EXACT [] synonym: "glucocorticosteroid metabolic process" EXACT [] synonym: "glucocorticosteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process -is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0008212 @@ -79560,7 +79802,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:curators] synonym: "spermine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process -is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0008216 @@ -79657,7 +79898,6 @@ name: tyramine receptor activity namespace: molecular_function def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [GOC:curators] is_a: GO:0008227 ! G protein-coupled amine receptor activity -is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0008227 @@ -79716,6 +79956,8 @@ is_a: GO:0008230 ! ecdysone receptor holocomplex id: GO:0008233 name: peptidase activity namespace: molecular_function +alt_id: GO:0070010 +alt_id: GO:0070011 def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_aspergillus subset: goslim_candida @@ -79726,19 +79968,25 @@ subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] +synonym: "peptidase activity, acting on D-amino acid peptides" NARROW [] +synonym: "peptidase activity, acting on L-amino acid peptides" NARROW [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4 xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6" xref: Reactome:R-HSA-3000243 "Unknown protease degrades GIF:Cbl to release Cbl" +xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA" +xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs" xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion" xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT" +xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB" xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)" xref: Reactome:R-HSA-5655483 "USP1 autocleavage" xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB" xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC" xref: Reactome:R-HSA-5693319 "CTRC hydrolyses PRSS1" +xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0006508 ! proteolysis @@ -79755,7 +80003,7 @@ xref: Reactome:R-HSA-2022381 "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-( xref: Reactome:R-HSA-2467775 "Autocleavage of ESPL1 (Separase)" xref: Reactome:R-HSA-2467809 "ESPL1 (Separase) cleaves centromeric cohesin" xref: Reactome:R-HSA-5660752 "USP9X deubiquitinates Ub-SNCA" -is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides +is_a: GO:0008233 ! peptidase activity [Term] id: GO:0008235 @@ -79771,12 +80019,13 @@ name: serine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] synonym: "serine protease activity" NARROW [] +xref: EC:3 xref: Reactome:R-HSA-1461993 "pro-HD5 is cleaved by trypsin" xref: Reactome:R-HSA-2022383 "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: Reactome:R-HSA-3132753 "Pancreatic proteases degrade TCN1:Cbl" xref: Reactome:R-HSA-6801766 "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)" +is_a: GO:0008233 ! peptidase activity is_a: GO:0017171 ! serine hydrolase activity -is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008237 @@ -79806,7 +80055,8 @@ xref: Reactome:R-HSA-5211405 "Anthrax LF cleaves target cell MAP2K6 (MEK6)" xref: Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)" xref: Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3" xref: Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4" -is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides +xref: Reactome:R-HSA-9662837 "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163" +is_a: GO:0008233 ! peptidase activity [Term] id: GO:0008238 @@ -79814,13 +80064,17 @@ name: exopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] synonym: "exoprotease activity" NARROW [] -is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides +is_a: GO:0008233 ! peptidase activity [Term] id: GO:0008239 name: dipeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] +xref: EC:3.4.14.11 +xref: EC:3.4.14.4 +xref: MetaCyc:3.4.14.11-RXN +xref: MetaCyc:3.4.14.4-RXN is_a: GO:0004177 ! aminopeptidase activity [Term] @@ -79829,10 +80083,11 @@ name: tripeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah] xref: EC:3.4.14 +xref: EC:3.4.14.10 +xref: EC:3.4.14.9 xref: MetaCyc:3.4.14.10-RXN xref: MetaCyc:3.4.14.9-RXN -is_a: GO:0008236 ! serine-type peptidase activity -is_a: GO:0008238 ! exopeptidase activity +is_a: GO:0070009 ! serine-type aminopeptidase activity [Term] id: GO:0008241 @@ -79846,10 +80101,14 @@ is_a: GO:0008238 ! exopeptidase activity id: GO:0008242 name: omega peptidase activity namespace: molecular_function -def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] +def: "Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379] synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED [] xref: EC:3.4.19 -is_a: GO:0008238 ! exopeptidase activity +xref: EC:3.4.19.2 +xref: EC:3.4.19.9 +xref: MetaCyc:3.4.19.9-RXN +xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN +is_a: GO:0008233 ! peptidase activity [Term] id: GO:0008243 @@ -79878,10 +80137,6 @@ synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "urokinase activity" RELATED [EC:3.4.21.-] synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68] synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] -xref: EC:3.4.21.68 -xref: EC:3.4.21.73 -xref: MetaCyc:3.4.21.68-RXN -xref: MetaCyc:3.4.21.73-RXN is_obsolete: true replaced_by: GO:0004252 @@ -79963,6 +80218,7 @@ synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31] synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31] xref: EC:3.1.3.31 xref: MetaCyc:NUCLEOTIDASE-RXN +xref: RHEA:22140 is_a: GO:0016791 ! phosphatase activity [Term] @@ -80000,6 +80256,7 @@ xref: Reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG" xref: Reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)" xref: Reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+" xref: Reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN" +xref: RHEA:12484 is_a: GO:0008252 ! nucleotidase activity [Term] @@ -80014,6 +80271,7 @@ synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6] xref: EC:3.1.3.6 xref: MetaCyc:3-NUCLEOTID-RXN +xref: RHEA:10144 is_a: GO:0008252 ! nucleotidase activity [Term] @@ -80034,6 +80292,7 @@ synonym: "HK2" RELATED [EC:2.7.13.1] synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1] xref: EC:2.7.13.1 xref: MetaCyc:2.7.13.1-RXN +xref: RHEA:22720 is_a: GO:0004673 ! protein histidine kinase activity [Term] @@ -80047,6 +80306,7 @@ synonym: "HK3" RELATED [EC:2.7.13.2] synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2] xref: EC:2.7.13.2 xref: MetaCyc:2.7.13.2-RXN +xref: RHEA:11860 is_a: GO:0004673 ! protein histidine kinase activity [Term] @@ -80402,9 +80662,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] synonym: "acetylcholine metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process -is_a: GO:0042445 ! hormone metabolic process is_a: GO:1900619 ! acetate ester metabolic process [Term] @@ -80418,7 +80676,6 @@ synonym: "acetylcholine formation" EXACT [] synonym: "acetylcholine synthesis" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process -is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:1900620 ! acetate ester biosynthetic process [Term] @@ -80704,7 +80961,6 @@ namespace: molecular_function def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "prenyl protein specific endopeptidase activity" EXACT [] -xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 @@ -80718,10 +80974,13 @@ def: "Enables the transfer of a protein from one side of a membrane to the other synonym: "protein channel activity" RELATED [] xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space" xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix" +xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex" +xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane" xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria" xref: Reactome:R-HSA-5210943 "PA63:ANTRX2 oligomer transports EF and LF (target cell endosome to cytosol)" xref: Reactome:R-HSA-5210947 "PA63:ANTRX1 oligomer transports EF and LF (target cell endosome to cytosol)" xref: Reactome:R-HSA-5228406 "TeNT HC transports TeNT LC from target cell endosome membrane into cytosol" +xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen" xref: Reactome:R-HSA-5244404 "BoNT/B HC transports BoNT/B LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244428 "BoNT/A HC transports BoNT/A LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5244506 "BoNT/E HC transports BoNT/E LC from target cell synaptic vesicle membrane into cytosol" @@ -80730,6 +80989,7 @@ xref: Reactome:R-HSA-5250616 "BoNT/D HC transports BoNT/D LC from target cell sy xref: Reactome:R-HSA-5250884 "BoNT/F HC transports BoNT/F LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5250972 "BoNT/G HC transports BoNT/G LC from target cell synaptic vesicle membrane into cytosol" xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane" +xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol" is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:0140318 ! protein transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity @@ -80787,7 +81047,6 @@ id: GO:0008330 name: protein tyrosine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] -xref: EC:3.1.3 is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] @@ -80858,7 +81117,7 @@ synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT [] xref: EC:1.14.11.1 xref: KEGG_REACTION:R02397 xref: MetaCyc:1.14.11.1-RXN -xref: Reactome:R-HSA-71261 "BBOX1:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA" +xref: Reactome:R-HSA-71261 "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA" xref: RHEA:24028 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity @@ -80982,6 +81241,7 @@ synonym: "MAP4K activity" EXACT [PMID:20811974] synonym: "MAPKKKK" EXACT [] xref: Reactome:R-HSA-177692 "Activation of recruited TAK1 within the activated TLR3 complex" xref: Reactome:R-HSA-936991 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3" +xref: Reactome:R-HSA-9645442 "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex" is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: part_of GO:0000165 ! MAPK cascade relationship: part_of GO:0000185 ! activation of MAPKKK activity @@ -81034,6 +81294,7 @@ xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN xref: Reactome:R-HSA-167191 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex" xref: Reactome:R-HSA-170704 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex" xref: Reactome:R-HSA-170706 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex" +xref: RHEA:10216 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] @@ -81194,6 +81455,7 @@ id: GO:0008373 name: sialyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins." [GOC:cjm, PMID:26192491, Wikipedia:Sialyltransferase] +xref: Reactome:R-HSA-9683769 "O-glycosylation of 3a is terminated" xref: Reactome:R-HSA-981814 "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups relationship: part_of GO:0097503 ! sialylation @@ -81224,6 +81486,7 @@ def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-ac synonym: "GlcNAc transferase activity" EXACT [] xref: Reactome:R-HSA-5694487 "A4GNT transfers GlcNAc to core 2 mucins" xref: Reactome:R-HSA-8879117 "POMGNT2 transfers GlcNAc to Man-DAG1" +xref: Reactome:R-HSA-9683648 "Spike trimer glycoside chains are extended" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -81323,6 +81586,7 @@ xref: EC:2.7.11.10 xref: MetaCyc:2.7.11.10-RXN xref: Reactome:R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex" xref: Reactome:R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400" +xref: RHEA:19073 is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: part_of GO:0007252 ! I-kappaB phosphorylation @@ -81364,6 +81628,7 @@ xref: MetaCyc:1.14.15.6-RXN xref: Reactome:R-HSA-193054 "Oxidation of cholesterol to 22beta-hydroxycholesterol" xref: Reactome:R-HSA-193065 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol" xref: Reactome:R-HSA-193101 "CYP11A1 cleaves 20a,22b-DHCHOL" +xref: RHEA:35739 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen @@ -81459,6 +81724,7 @@ xref: Reactome:R-HSA-5602170 "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-tr xref: Reactome:R-HSA-6785244 "Defective CYP11B2 does not oxidise 18HCORST" xref: Reactome:R-HSA-6785245 "Defective CYP11B2 does not oxidise CORST" xref: Reactome:R-HSA-9035960 "Defective CYP27A1 does not 27-hydroxylate 5-CHOL3,7,24(s)-triol" +xref: RHEA:43836 is_a: GO:0004497 ! monooxygenase activity [Term] @@ -81624,6 +81890,7 @@ synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT [] synonym: "PHB polyprenyl diphosphate transferase activity" EXACT [] xref: EC:2.5.1 xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN +xref: RHEA:27782 is_a: GO:0002094 ! polyprenyltransferase activity [Term] @@ -81689,6 +81956,7 @@ synonym: "long-chain-fatty-acyl-glutamate deacylase activity" EXACT [] synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55] xref: EC:3.5.1.55 xref: MetaCyc:3.5.1.55-RXN +xref: RHEA:17517 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -81727,8 +81995,6 @@ def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glyco comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40] synonym: "bleomycin hydrolase activity" EXACT [] -xref: EC:3.4.22.40 -xref: MetaCyc:3.4.22.40-RXN is_obsolete: true replaced_by: GO:0004197 @@ -82071,8 +82337,6 @@ synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57] synonym: "O-sialoglycoprotein endopeptidase activity" EXACT [] synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57] synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57] -xref: EC:3.4.24.57 -xref: MetaCyc:3.4.24.57-RXN is_obsolete: true replaced_by: GO:0004222 @@ -82087,8 +82351,6 @@ synonym: "aminopeptidase P" EXACT [] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9] synonym: "X-Pro aminopeptidase activity" EXACT [] synonym: "Xaa-Pro aminopeptidase activity" EXACT [] -xref: EC:3.4.11.9 -xref: MetaCyc:3.4.11.9-RXN is_obsolete: true replaced_by: GO:0004177 @@ -82135,6 +82397,7 @@ synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosamin xref: EC:2.4.1.145 xref: MetaCyc:2.4.1.145-RXN xref: Reactome:R-HSA-975903 "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV" +xref: RHEA:16057 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein @@ -82179,6 +82442,7 @@ synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49] xref: EC:3.2.1.49 xref: MetaCyc:3.2.1.49-RXN +xref: RHEA:15085 is_a: GO:0015929 ! hexosaminidase activity [Term] @@ -82259,8 +82523,6 @@ synonym: "ClpP" RELATED [EC:3.4.21.92] synonym: "endopeptidase Clp activity" EXACT [] synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92] synonym: "protease Ti activity" RELATED [EC:3.4.21.92] -xref: EC:3.4.21.92 -xref: MetaCyc:3.4.21.92-RXN is_obsolete: true replaced_by: GO:0004252 @@ -82295,8 +82557,6 @@ synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9] synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] -xref: EC:3.4.19.9 -xref: MetaCyc:3.4.19.9-RXN is_obsolete: true replaced_by: GO:0008242 @@ -82330,6 +82590,7 @@ xref: Reactome:R-HSA-3322014 "Autoglucosylation of GYG2 complexed with GYS2-a" xref: Reactome:R-HSA-3322019 "Autoglucosylation of GYG2 complexed with GYS2-b" xref: Reactome:R-HSA-3322025 "Autoglucosylation of GYG1 complexed with GYS1-a" xref: Reactome:R-HSA-3814838 "Defective GYG1 is not autoglucosyolated" +xref: RHEA:23360 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -82414,8 +82675,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22] synonym: "gp180 (duck)" RELATED [EC:3.4.17.22] synonym: "metallocarboxypeptidase D activity" EXACT [] -xref: EC:3.4.17.22 -xref: MetaCyc:3.4.17.22-RXN is_obsolete: true replaced_by: GO:0004181 @@ -82451,6 +82710,8 @@ xref: MetaCyc:3.1.2.22-RXN xref: Reactome:R-HSA-203613 "depalmitoylation of eNOS" xref: Reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins" xref: Reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43" +xref: Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated" +xref: RHEA:19233 is_a: GO:0016790 ! thiolester hydrolase activity is_a: GO:0098599 ! palmitoyl hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -82474,6 +82735,7 @@ synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4] xref: EC:1.14.11.4 xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN xref: Reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines" +xref: RHEA:16569 is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity [Term] @@ -82488,6 +82750,9 @@ synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20] xref: EC:2.8.2.20 xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-8954262 "TPST1,2 transfer SO4(2-) from PAPS to PODXL2" +xref: Reactome:R-HSA-9668023 "TPST1,2 transfer SO4(2-) from PAPS to FVIII" +xref: Reactome:R-HSA-9668148 "F8 variant is not sulfonated at Y1699" +xref: RHEA:16801 is_a: GO:0008146 ! sulfotransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -82513,6 +82778,7 @@ synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1 synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1] xref: EC:3.2.2.1 xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN +xref: RHEA:23344 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] @@ -82554,6 +82820,7 @@ synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29] xref: EC:2.4.2.29 xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-6782443 "QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)" +xref: RHEA:16633 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -82615,6 +82882,7 @@ def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-ox synonym: "aminotransferase activity" EXACT [] xref: EC:2.6.1 xref: Reactome:R-HSA-1237102 "Transamination of MOB to methionine" +xref: RHEA:31763 is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] @@ -82667,6 +82935,7 @@ xref: Reactome:R-HSA-159826 "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin xref: Reactome:R-HSA-163810 "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)" xref: Reactome:R-HSA-163820 "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)" xref: Reactome:R-HSA-6807214 "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)" +xref: Reactome:R-HSA-9673231 "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX)" xref: RHEA:45140 is_a: GO:0016831 ! carboxy-lyase activity @@ -83002,7 +83271,8 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "sodium-dependent L-ascorbic acid transporter" RELATED [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005402 ! carbohydrate:cation symporter activity -is_a: GO:0015229 ! L-ascorbic acid transmembrane transporter activity +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0008521 @@ -83014,7 +83284,6 @@ xref: Reactome:R-HSA-5649742 "Defective SLC33A1 does not transport Ac-CoA from c xref: Reactome:R-HSA-727759 "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity -is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0015876 ! acetyl-CoA transport @@ -83148,8 +83417,6 @@ synonym: "astacin activity" EXACT [] synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21] synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21] synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21] -xref: EC:3.4.24.21 -xref: MetaCyc:3.4.24.21-RXN is_obsolete: true replaced_by: GO:0004222 @@ -83168,17 +83435,17 @@ synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23] synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23] synonym: "DNA glycosylase/AP-lyase activity" BROAD [] synonym: "DNA glycosylase/beta-lyase activity" BROAD [] -synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT [] -synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] -synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT [] +synonym: "DNA-formamidopyrimidine glycosylase activity" RELATED [] +synonym: "Fapy-DNA glycosylase activity" RELATED [EC:3.2.2.23] +synonym: "formamidopyrimidine-DNA glycosylase activity" RELATED [] synonym: "Fpg protein" RELATED [EC:3.2.2.23] synonym: "oxidized purine base lesion DNA N-glycosylase activity" EXACT [] synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: EC:3.2.2.23 xref: MetaCyc:3.2.2.23-RXN xref: Reactome:R-HSA-110229 "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase" -xref: Reactome:R-HSA-110243 "Cleavage of 8-oxoguanine by OGG1 glycosylase" -xref: Reactome:R-HSA-110244 "Cleavage of formamidopyrimidine (FapyG) by OGG1 glycosylase" +xref: Reactome:R-HSA-110243 "Excision of 8-oxoguanine by OGG1 glycosylase" +xref: Reactome:R-HSA-110244 "Excision of FapyG by OGG1 glycosylase" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity [Term] @@ -83448,7 +83715,6 @@ synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11] xref: EC:3.6.3.11 xref: MetaCyc:3.6.3.11-RXN -xref: RHEA:24128 is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity @@ -83514,6 +83780,7 @@ xref: Reactome:R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to xref: Reactome:R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate" xref: Reactome:R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate" is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity [Term] id: GO:0008563 @@ -83546,9 +83813,6 @@ synonym: "enzyme transporter activity" NARROW [] synonym: "holin" RELATED [] synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "secretin" RELATED [] -xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex" -xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane" -xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen" is_obsolete: true [Term] @@ -83583,6 +83847,7 @@ synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [] synonym: "katanin activity" NARROW [EC:5.6.1.1] xref: EC:5.6.1.1 xref: MetaCyc:3.6.4.3-RXN +xref: Reactome:R-HSA-9668419 "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites" is_a: GO:0016887 ! ATPase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0051013 ! microtubule severing @@ -83932,6 +84197,7 @@ synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.2 xref: EC:2.5.1.26 xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN xref: Reactome:R-HSA-390427 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate" +xref: RHEA:36171 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] @@ -83999,7 +84265,6 @@ def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydro synonym: "pyridoxine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0042816 ! vitamin B6 metabolic process -is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] @@ -84014,7 +84279,6 @@ synonym: "pyridoxine synthesis" EXACT [] is_a: GO:0008614 ! pyridoxine metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042819 ! vitamin B6 biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] @@ -84076,6 +84340,7 @@ def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H synonym: "chromatin accessibility complex" EXACT [] synonym: "ISW2 complex" NARROW [] is_a: GO:0031010 ! ISWI-type complex +property_value: RO:0002161 NCBITaxon:4896 [Term] id: GO:0008625 @@ -84456,6 +84721,7 @@ synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXA synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16] xref: EC:3.1.4.16 xref: MetaCyc:CYCPHOSDIESTER-RXN +xref: RHEA:19621 is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] @@ -84523,6 +84789,7 @@ synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34] synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34] xref: EC:1.3.1.34 xref: MetaCyc:DIENOYLCOAREDUCT-RXN +xref: RHEA:12136 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -84793,6 +85060,7 @@ def: "Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + xref: EC:1.14.13 xref: KEGG_REACTION:R06786 xref: MetaCyc:MHPHYDROXY-RXN +xref: RHEA:24785 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -85161,6 +85429,7 @@ namespace: molecular_function def: "Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+." [MetaCyc:RXN0-5061] synonym: "ADP-heptose:LPS heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY] xref: MetaCyc:RXN0-5061 +xref: RHEA:28538 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity [Term] @@ -85218,7 +85487,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "D-alanyl-D-alanine endopeptidase activity" EXACT [] synonym: "penicillin-binding protein 7" NARROW [] synonym: "penicillin-binding protein 8" NARROW [] -xref: EC:3.4.99 is_obsolete: true replaced_by: GO:0004175 @@ -85271,12 +85539,13 @@ synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18] +synonym: "D-serine dehydration activity" RELATED [] synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18] xref: EC:4.3.1.18 xref: MetaCyc:DSERDEAM-RXN -xref: Reactome:R-HSA-9014741 "SRR dimer:PXLP deaminates D-Ser" -xref: Reactome:R-HSA-9034539 "SRR dimer:PXLP deaminates L-Ser" +xref: Reactome:R-HSA-9014741 "PXLP-K56-SRR dimer deaminates D-Ser" +xref: Reactome:R-HSA-9034539 "PXLP-K56-SRR dimer deaminates L-Ser" xref: RHEA:13977 is_a: GO:0016841 ! ammonia-lyase activity @@ -85321,6 +85590,7 @@ synonym: "SsuD" RELATED [EC:1.14.14.5] synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5] xref: EC:1.14.14.5 xref: MetaCyc:RXN0-280 +xref: RHEA:23064 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] @@ -85329,6 +85599,7 @@ name: GDP-mannose mannosyl hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+." [MetaCyc:GDPMANMANHYDRO-RXN] xref: MetaCyc:GDPMANMANHYDRO-RXN +xref: RHEA:28102 is_a: GO:0015923 ! mannosidase activity [Term] @@ -85379,6 +85650,7 @@ synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT [] synonym: "LtaA" RELATED [] xref: EC:4.1.2 xref: MetaCyc:LTAA-RXN +xref: RHEA:26209 is_a: GO:0004793 ! threonine aldolase activity [Term] @@ -85487,6 +85759,7 @@ synonym: "L-ribulokinase activity" EXACT [] synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16] xref: EC:2.7.1.16 xref: MetaCyc:RIBULOKIN-RXN +xref: RHEA:22072 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity @@ -85614,6 +85887,7 @@ name: N-ethylmaleimide reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+." [MetaCyc:RXN0-5101] xref: MetaCyc:RXN0-5101 +xref: RHEA:35523 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -85725,6 +85999,7 @@ name: UDP-2,3-diacylglucosamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770] xref: MetaCyc:LIPIDXSYNTHESIS-RXN +xref: RHEA:25213 is_a: GO:0016462 ! pyrophosphatase activity [Term] @@ -85865,6 +86140,7 @@ def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl- comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10). xref: EC:6.3.2 xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN +xref: RHEA:28374 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] @@ -85928,6 +86204,7 @@ synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14] synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] xref: EC:3.1.4.14 xref: MetaCyc:3.1.4.14-RXN +xref: RHEA:20537 is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -85945,6 +86222,7 @@ synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22] xref: EC:6.2.1.22 xref: KEGG_REACTION:R04449 xref: MetaCyc:CITC-RXN +xref: RHEA:23788 is_a: GO:0016878 ! acid-thiol ligase activity [Term] @@ -85965,6 +86243,7 @@ synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase/phosphatase activity" BROAD [EC:2.7.11.5] xref: EC:2.7.11.5 xref: MetaCyc:PHOSICITDEHASE-RXN +xref: RHEA:43540 is_a: GO:0004672 ! protein kinase activity [Term] @@ -85980,6 +86259,7 @@ synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT [] synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] xref: EC:2.7.7.59 xref: MetaCyc:URITRANS-RXN +xref: RHEA:13673 is_a: GO:0070569 ! uridylyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -86029,6 +86309,7 @@ synonym: "AK activity" EXACT [EC:2.7.2.1] synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1] xref: EC:2.7.2.1 xref: MetaCyc:ACETATEKIN-RXN +xref: RHEA:11352 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor @@ -86058,6 +86339,7 @@ synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXA synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40] xref: EC:2.3.1.40 xref: MetaCyc:ACYLGPEACYLTRANS-RXN +xref: RHEA:10304 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -86073,6 +86355,7 @@ synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] xref: EC:2.3.1.129 xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN +xref: RHEA:13925 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -86123,6 +86406,7 @@ synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9] xref: EC:3.2.2.9 xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN +xref: RHEA:17805 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] @@ -86271,6 +86555,7 @@ synonym: "aromatic aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid transaminase activity" EXACT [EC:2.6.1.57] xref: EC:2.6.1.57 xref: MetaCyc:2.6.1.57-RXN +xref: RHEA:17533 xref: UM-BBD_reactionID:r0297 is_a: GO:0008483 ! transaminase activity @@ -86282,6 +86567,7 @@ def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + ox synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1] xref: EC:1.20.4.1 xref: MetaCyc:RXN-982 +xref: RHEA:22016 xref: UM-BBD_reactionID:r0635 is_a: GO:0030611 ! arsenate reductase activity is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor @@ -86341,6 +86627,7 @@ xref: MetaCyc:3.4.19.5-RXN xref: Reactome:R-HSA-5692495 "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)" xref: Reactome:R-HSA-5696365 "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe" is_a: GO:0008242 ! omega peptidase activity +is_a: GO:0070003 ! threonine-type peptidase activity [Term] id: GO:0008800 @@ -86360,6 +86647,7 @@ synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "penicillinase I, II" RELATED [EC:3.5.2.6] xref: EC:3.5.2.6 xref: MetaCyc:BETA-LACTAMASE-RXN +xref: RHEA:20401 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] @@ -86448,6 +86736,7 @@ synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4] synonym: "cytochrome b561" NARROW [] xref: EC:1.2.2.4 xref: MetaCyc:1.2.2.4-RXN +xref: RHEA:13981 xref: UM-BBD_reactionID:r0650 xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561) is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor @@ -86764,6 +87053,7 @@ synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cy synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79] xref: EC:2.1.1.79 xref: MetaCyc:2.1.1.79-RXN +xref: RHEA:11988 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -86774,6 +87064,7 @@ def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite." [MetaC synonym: "cysteine sulphinate desulphinase activity" EXACT [] xref: EC:4.4.1 xref: MetaCyc:RXN0-279 +xref: RHEA:28278 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] @@ -87067,8 +87358,6 @@ synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53] synonym: "protease La" RELATED [EC:3.4.21.53] synonym: "proteinase La" RELATED [EC:3.4.21.53] synonym: "serine protease La" RELATED [EC:3.4.21.53] -xref: EC:3.4.21.53 -xref: MetaCyc:3.4.21.53-RXN is_obsolete: true replaced_by: GO:0004252 @@ -87103,6 +87392,7 @@ namespace: molecular_function def: "Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+." [MetaCyc:RXN0-1661, PMID:4565531] synonym: "enterobactin esterase activity" EXACT [] xref: MetaCyc:RXN0-1661 +xref: RHEA:28018 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] @@ -87223,6 +87513,7 @@ synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3] xref: EC:1.18.1.3 xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN +xref: RHEA:16521 is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity [Term] @@ -87363,6 +87654,7 @@ synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18] xref: EC:2.3.1.18 xref: MetaCyc:GALACTOACETYLTRAN-RXN +xref: RHEA:15713 is_a: GO:0016413 ! O-acetyltransferase activity [Term] @@ -87539,6 +87831,7 @@ synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT [] synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] xref: EC:2.7.7.42 xref: MetaCyc:GSADENYLATION-RXN +xref: RHEA:18589 is_a: GO:0070566 ! adenylyltransferase activity [Term] @@ -87650,6 +87943,7 @@ xref: EC:3.1.4.46 xref: MetaCyc:GLYCPDIESTER-RXN xref: Reactome:R-HSA-1483107 "GPETA is hydrolyzed to ETA and G3P by GPCPD1" xref: Reactome:R-HSA-1483116 "GPCho is hydrolyzed to Cho and G3P by GPCPD1" +xref: RHEA:12969 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] @@ -87676,6 +87970,7 @@ namespace: molecular_function def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide." [EC:1.1.3.15] xref: MetaCyc:RXN-969 xref: Reactome:R-HSA-389842 "HAO1 tetramer oxidizes glycolate to glyoxylate" +xref: RHEA:25311 is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity [Term] @@ -87763,6 +88058,7 @@ synonym: "PPTase activity" EXACT [EC:2.7.8.7] xref: EC:2.7.8.7 xref: MetaCyc:HOLO-ACP-SYNTH-RXN xref: Reactome:R-HSA-199202 "Phosphopantetheine conjugation of the ACP domain of FAS" +xref: RHEA:12068 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] @@ -87859,6 +88155,7 @@ synonym: "nickel-iron-selenium hydrogenase activity" NARROW [] synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2] xref: EC:1.12.7.2 xref: MetaCyc:HYDROG-RXN +xref: RHEA:17445 xref: UM-BBD_enzymeID:e0418 is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor @@ -87973,8 +88270,8 @@ id: GO:0008910 name: kanamycin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate." [EC:2.7.1.95, RHEA:24256] -synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95] -synonym: "APH(3') activity" EXACT [EC:2.7.1.95] +synonym: "aminoglycoside 3'-phosphotransferase activity" BROAD [EC:2.7.1.95] +synonym: "APH(3') activity" BROAD [EC:2.7.1.95] synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95] synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95] @@ -88032,6 +88329,7 @@ synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] xref: EC:2.3.2.6 xref: MetaCyc:LEUCYLTRANSFERASE-RXN +xref: RHEA:12340 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] @@ -88051,7 +88349,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups id: GO:0008917 name: lipopolysaccharide N-acetylglucosaminyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56, GOC:mr, KEGG:00540] +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56, GOC:mr] synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT [] synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] @@ -88065,7 +88363,7 @@ relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process id: GO:0008918 name: lipopolysaccharide 3-alpha-galactosyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44, GOC:mr, KEGG:00540] +def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44, GOC:mr] synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "lipopolysaccharide galactosyltransferase activity" EXACT [] synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW [] @@ -88085,7 +88383,7 @@ relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process id: GO:0008919 name: lipopolysaccharide glucosyltransferase I activity namespace: molecular_function -def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58, GOC:mr, KEGG:00540] +def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58, GOC:mr] synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "LPS glucosyltransferase I activity" EXACT [] synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] @@ -88135,6 +88433,7 @@ synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20] xref: EC:6.2.1.20 xref: KEGG_REACTION:R07325 xref: MetaCyc:ACYLACPSYNTH-RXN +xref: RHEA:45588 is_a: GO:0015645 ! fatty acid ligase activity [Term] @@ -88452,8 +88751,6 @@ def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specifi comment: This term was made obsolete because it represents a gene product. synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70] synonym: "oligopeptidase A activity" EXACT [] -xref: EC:3.4.24.70 -xref: MetaCyc:3.4.24.70-RXN is_obsolete: true replaced_by: GO:0004222 @@ -88466,8 +88763,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83] synonym: "oligopeptidase B activity" EXACT [] synonym: "protease II activity" EXACT [EC:3.4.21.83] -xref: EC:3.4.21.83 -xref: MetaCyc:3.4.21.83-RXN is_obsolete: true replaced_by: GO:0004252 @@ -88488,8 +88783,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87] comment: This term was made obsolete because it represents a gene product. synonym: "omptin activity" EXACT [] -xref: EC:3.4.21.87 -xref: MetaCyc:3.4.21.87-RXN is_obsolete: true replaced_by: GO:0004252 @@ -88544,6 +88837,7 @@ namespace: molecular_function def: "Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]." [MetaCyc:PALMITOTRANS-RXN] synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT [] xref: MetaCyc:PALMITOTRANS-RXN +xref: RHEA:44012 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -88588,6 +88882,7 @@ synonym: "PG-II activity" EXACT [EC:2.4.1.129] synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129] xref: EC:2.4.1.129 xref: MetaCyc:RXN0-5405 +xref: RHEA:23708 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -88688,6 +88983,7 @@ synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13] xref: EC:2.7.8.13 xref: MetaCyc:RXN-8975 +xref: RHEA:21920 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] @@ -88723,6 +89019,7 @@ synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3. synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9] xref: EC:2.7.3.9 xref: MetaCyc:2.7.3.9-RXN +xref: RHEA:23880 is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] @@ -88761,6 +89058,7 @@ namespace: molecular_function def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969] synonym: "phosphoheptose isomerase activity" EXACT [] xref: MetaCyc:RXN0-4301 +xref: RHEA:27489 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] @@ -88780,6 +89078,7 @@ xref: Reactome:R-HSA-1482892 "PE is hydrolyzed to 2-acyl LPE by PLA2G4C" xref: Reactome:R-HSA-1482920 "PG is hydrolyzed to 2-acyl LPG by PLA2[14]" xref: Reactome:R-HSA-1482932 "PI is hydrolyzed to 2-acyl LPI by PLA2[13]" xref: Reactome:R-HSA-5694485 "ABHD3 hydrolyses LPC(14:0) to 1AGPC" +xref: RHEA:18689 is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity @@ -88849,8 +89148,6 @@ synonym: "protease III activity" EXACT [EC:3.4.24.55] synonym: "protease Pi activity" EXACT [EC:3.4.24.55] synonym: "proteinase Pi" RELATED [EC:3.4.24.55] synonym: "PTR" RELATED [EC:3.4.24.55] -xref: EC:3.4.24.55 -xref: MetaCyc:3.4.24.55-RXN is_obsolete: true replaced_by: GO:0004222 @@ -88865,6 +89162,7 @@ synonym: "polyphosphate polymerase activity" EXACT [] synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1] xref: EC:2.7.4.1 xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN +xref: RHEA:19573 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor @@ -88889,8 +89187,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43] comment: This term was made obsolete because it represents a gene product. synonym: "prepilin peptidase activity" EXACT [] -xref: EC:3.4.23.43 -xref: MetaCyc:3.4.23.43-RXN is_obsolete: true replaced_by: GO:0004190 @@ -88914,6 +89210,7 @@ synonym: "PduW" RELATED [] synonym: "propanoate kinase activity" EXACT [] synonym: "TdcD" RELATED [] xref: EC:2.7.2.15 +xref: RHEA:23148 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor @@ -88987,6 +89284,7 @@ synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EX xref: EC:2.1.1.80 xref: MetaCyc:CHER-RXN xref: RESID:AA0072 +xref: RHEA:24452 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity @@ -89004,6 +89302,7 @@ synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC: xref: EC:3.1.1.61 xref: MetaCyc:MCPMETEST-RXN xref: RESID:AA0072 +xref: RHEA:23236 is_a: GO:0051723 ! protein methylesterase activity [Term] @@ -89047,6 +89346,7 @@ name: quinolinate synthetase A activity namespace: molecular_function def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN] xref: MetaCyc:QUINOLINATE-SYNTHA-RXN +xref: RHEA:25888 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups relationship: part_of GO:0019805 ! quinolinate biosynthetic process @@ -89097,7 +89397,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. synonym: "serine-type signal peptidase activity" EXACT [] -xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 @@ -89110,8 +89409,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "LexA repressor" RELATED [EC:3.4.21.88] synonym: "repressor lexA" RELATED [EC:3.4.21.88] synonym: "repressor LexA activity" EXACT [] -xref: EC:3.4.21.88 -xref: MetaCyc:3.4.21.88-RXN is_obsolete: true replaced_by: GO:0004252 @@ -89192,6 +89489,7 @@ synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" E synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128] xref: EC:2.3.1.128 xref: MetaCyc:2.3.1.128-RXN +xref: RHEA:43756 is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity [Term] @@ -89204,7 +89502,7 @@ synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16] synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16] xref: EC:4.4.1.16 xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN -xref: Reactome:R-HSA-2408524 "Sec is reduced to H2Se by SCLY" +xref: Reactome:R-HSA-2408524 "Sec is reduced to H2Se by PXLP-K259-SCLY dimer" xref: RHEA:11632 is_a: GO:0016846 ! carbon-sulfur lyase activity @@ -89282,8 +89580,6 @@ synonym: "signal proteinase activity" EXACT [EC:3.4.21.89] synonym: "signalase activity" EXACT [EC:3.4.21.89] synonym: "SPase I activity" EXACT [EC:3.4.21.89] synonym: "SPC" RELATED [EC:3.4.21.89] -xref: EC:3.4.21.89 -xref: MetaCyc:3.4.21.89-RXN is_obsolete: true replaced_by: GO:0004252 @@ -89301,8 +89597,6 @@ synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "signal peptidase II activity" EXACT [] synonym: "SPase II activity" EXACT [EC:3.4.23.36] -xref: EC:3.4.23.36 -xref: MetaCyc:3.4.23.36-RXN is_obsolete: true replaced_by: GO:0004190 @@ -89332,6 +89626,7 @@ synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72] xref: EC:2.1.1.72 xref: MetaCyc:2.1.1.72-RXN +xref: RHEA:15197 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity relationship: part_of GO:0032775 ! DNA methylation on adenine @@ -89350,7 +89645,6 @@ synonym: "DNA methylase" BROAD [] synonym: "DNA methyltransferase activity" EXACT [] synonym: "DNA transmethylase activity" EXACT [] synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37] -xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3" xref: Reactome:R-HSA-5227490 "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes" is_a: GO:0008168 ! methyltransferase activity is_a: GO:0140097 ! catalytic activity, acting on DNA @@ -89388,19 +89682,19 @@ id: GO:0009011 name: starch synthase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21] -synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] -synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] +synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [] +synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [] synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21] -synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21] +synonym: "ADP-glucose transglucosylase activity" EXACT [] synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21] -synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] -synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21] -synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] -synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] -synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] +synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [] +synonym: "ADPG starch synthetase activity" EXACT [] +synonym: "ADPG-starch glucosyltransferase activity" EXACT [] +synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [] +synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [] synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21] synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21] -synonym: "starch synthetase activity" EXACT [EC:2.4.1.21] +synonym: "starch synthetase activity" EXACT [] xref: EC:2.4.1.21 xref: MetaCyc:GLYCOGENSYN-RXN is_a: GO:0046527 ! glucosyltransferase activity @@ -89536,6 +89830,7 @@ synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] xref: EC:2.1.1.34 xref: MetaCyc:2.1.1.34-RXN xref: Reactome:R-HSA-9024161 "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe)" +xref: RHEA:20077 is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity is_a: GO:0106050 ! tRNA 2'-O-methyltransferase activity @@ -89551,6 +89846,7 @@ synonym: "RNase PH activity" EXACT [EC:2.7.7.56] synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56] xref: EC:2.7.7.56 xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN +xref: RHEA:10628 is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -89624,6 +89920,7 @@ synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93] synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93] xref: EC:1.1.1.93 xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN +xref: RHEA:15209 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -89908,7 +90205,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. synonym: "aspartic-type signal peptidase activity" EXACT [] -xref: EC:3.4.23 is_obsolete: true replaced_by: GO:0004190 @@ -89970,7 +90266,6 @@ synonym: "electron acceptor activity" NARROW [] synonym: "electron carrier" RELATED [] synonym: "electron donor activity" NARROW [] synonym: "electron transporter activity" RELATED [] -xref: Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster" xref: Reactome:R-HSA-169260 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF" xref: Reactome:R-HSA-2564826 "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold" is_a: GO:0016491 ! oxidoreductase activity @@ -90563,7 +90858,6 @@ synonym: "vitamin H biosynthesis" EXACT [] synonym: "vitamin H biosynthetic process" EXACT [] xref: MetaCyc:BIOTIN-SYNTHESIS-PWY is_a: GO:0006768 ! biotin metabolic process -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0043604 ! amide biosynthetic process @@ -90582,6 +90876,7 @@ synonym: "lipopolysaccharide biosynthesis" EXACT [] synonym: "lipopolysaccharide formation" EXACT [] synonym: "lipopolysaccharide synthesis" EXACT [] synonym: "LPS biosynthetic process" EXACT [] +xref: KEGG_PATHWAY:map00540 is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0008653 ! lipopolysaccharide metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process @@ -90611,7 +90906,6 @@ synonym: "lipoate metabolism" EXACT [] synonym: "lipoic acid metabolic process" EXACT [] synonym: "lipoic acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -90633,37 +90927,36 @@ synonym: "lipoic acid formation" EXACT [] synonym: "lipoic acid synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0009106 ! lipoate metabolic process -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009108 -name: coenzyme biosynthetic process +name: obsolete coenzyme biosynthetic process namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group biosynthetic processes that are not all metabolically related by the fact that they may be used as a coenzyme. synonym: "coenzyme anabolism" EXACT [] synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] synonym: "coenzyme biosynthesis" EXACT [] synonym: "coenzyme formation" EXACT [] synonym: "coenzyme synthesis" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process -is_a: GO:0051188 ! cofactor biosynthetic process +is_obsolete: true [Term] id: GO:0009109 -name: coenzyme catabolic process +name: obsolete coenzyme catabolic process namespace: biological_process -def: "The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group catabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. synonym: "coenzyme and prosthetic group catabolic process" BROAD [] synonym: "coenzyme and prosthetic group catabolism" BROAD [] synonym: "coenzyme breakdown" EXACT [] synonym: "coenzyme catabolism" EXACT [] synonym: "coenzyme degradation" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process -is_a: GO:0051187 ! cofactor catabolic process +is_obsolete: true [Term] id: GO:0009110 @@ -91960,7 +92253,6 @@ synonym: "thiamine pyrophosphate biosynthesis" EXACT [] synonym: "thiamine pyrophosphate biosynthetic process" EXACT [] synonym: "TPP biosynthesis" EXACT [] synonym: "TPP biosynthetic process" EXACT [] -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042357 ! thiamine diphosphate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process @@ -92015,7 +92307,6 @@ synonym: "vitamin G catabolism" EXACT [] is_a: GO:0006771 ! riboflavin metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0009233 @@ -92060,9 +92351,7 @@ synonym: "vitamin B12 metabolic process" EXACT [] synonym: "vitamin B12 metabolism" EXACT [] synonym: "vitamin B12 reduction" NARROW [] is_a: GO:0006767 ! water-soluble vitamin metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process -is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0009236 @@ -92078,7 +92367,6 @@ synonym: "vitamin B12 biosynthetic process" EXACT [] is_a: GO:0009235 ! cobalamin metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0009237 @@ -92089,7 +92377,6 @@ synonym: "siderochrome metabolic process" NARROW [] synonym: "siderochrome metabolism" NARROW [] synonym: "siderophore metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process -is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0009238 @@ -92101,7 +92388,7 @@ synonym: "enterochelin metabolic process" EXACT [] synonym: "enterochelin metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process -is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0033067 ! macrolide metabolic process [Term] id: GO:0009239 @@ -92122,8 +92409,8 @@ synonym: "enterochelin biosynthetic process" EXACT [] xref: MetaCyc:ENTBACSYN-PWY is_a: GO:0009238 ! enterobactin metabolic process is_a: GO:0009713 ! catechol-containing compound biosynthetic process -is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019540 ! siderophore biosynthetic process from catechol +is_a: GO:0033068 ! macrolide biosynthetic process [Term] id: GO:0009240 @@ -92249,7 +92536,6 @@ alt_id: GO:0018055 def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118] synonym: "peptidyl-lysine lipoylation" EXACT [] synonym: "protein-lipoic acid cofactor linkage" EXACT [] -is_a: GO:0018065 ! protein-cofactor linkage is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0051604 ! protein maturation @@ -93392,11 +93678,9 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732] synonym: "vitamin B7 binding" EXACT [] synonym: "vitamin H binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0033218 ! amide binding is_a: GO:0033293 ! monocarboxylic acid binding -is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding @@ -93427,7 +93711,7 @@ def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in su comment: This term was made obsolete because it represents a gene product. synonym: "HslUV protease activity" EXACT [] is_obsolete: true -replaced_by: GO:0070011 +replaced_by: GO:0008233 [Term] id: GO:0009378 @@ -93605,7 +93889,6 @@ synonym: "vitamin B9 and derivative biosynthetic process" EXACT [] synonym: "vitamin M and derivative biosynthesis" EXACT [] synonym: "vitamin M and derivative biosynthetic process" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0043604 ! amide biosynthetic process @@ -93630,7 +93913,6 @@ synonym: "vitamin B9 and derivative catabolism" EXACT [] synonym: "vitamin M and derivative catabolic process" EXACT [] synonym: "vitamin M and derivative catabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process @@ -93644,7 +93926,6 @@ synonym: "FMN anabolism" EXACT [] synonym: "FMN biosynthesis" EXACT [] synonym: "FMN formation" EXACT [] synonym: "FMN synthesis" EXACT [] -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009260 ! ribonucleotide biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process @@ -94093,7 +94374,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732] synonym: "glycolate metabolism" EXACT [] xref: MetaCyc:GLYCOLATEMET-PWY -is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process @@ -94174,7 +94454,6 @@ synonym: "GABA metabolism" EXACT [] synonym: "gamma-aminobutyric acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process -is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0009449 @@ -94194,7 +94473,6 @@ synonym: "gamma-aminobutyric acid formation" EXACT [] synonym: "gamma-aminobutyric acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process -is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] @@ -94215,7 +94493,6 @@ synonym: "gamma-aminobutyric acid degradation" EXACT [] xref: MetaCyc:4AMINOBUTMETAB-PWY is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process -is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] @@ -94563,6 +94840,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]." [MetaCyc:RXN0-5268] xref: EC:1.10.3 xref: MetaCyc:RXN0-5268 +xref: RHEA:30251 is_a: GO:0015002 ! heme-copper terminal oxidase activity [Term] @@ -94673,6 +94951,7 @@ synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC: xref: EC:1.10.9.1 xref: KEGG_REACTION:R03817 xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN +xref: RHEA:22148 is_a: GO:0052880 ! oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor [Term] @@ -96375,7 +96654,6 @@ synonym: "gibberellic acid metabolism" NARROW [] synonym: "gibberellin metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process -is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0009686 @@ -96394,7 +96672,6 @@ xref: MetaCyc:PWY-5052 xref: MetaCyc:PWY-5070 is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0016102 ! diterpenoid biosynthetic process -is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] @@ -96469,7 +96746,6 @@ def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a synonym: "ethene metabolic process" EXACT [] synonym: "ethene metabolism" EXACT [] synonym: "ethylene metabolism" EXACT [] -is_a: GO:0042445 ! hormone metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] @@ -96490,7 +96766,6 @@ synonym: "ethylene formation" EXACT [] synonym: "ethylene synthesis" EXACT [] xref: MetaCyc:ETHYL-PWY is_a: GO:0009692 ! ethylene metabolic process -is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0043450 ! alkene biosynthetic process [Term] @@ -96500,7 +96775,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845] synonym: "jasmonic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process -is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0009695 @@ -96513,7 +96787,6 @@ synonym: "jasmonic acid formation" EXACT [] synonym: "jasmonic acid synthesis" EXACT [] xref: MetaCyc:PWY-735 is_a: GO:0009694 ! jasmonic acid metabolic process -is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] @@ -96522,10 +96795,8 @@ name: salicylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] synonym: "salicylic acid metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process -is_a: GO:0042445 ! hormone metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] @@ -96540,8 +96811,6 @@ synonym: "salicylic acid formation" EXACT [] synonym: "salicylic acid synthesis" EXACT [] xref: MetaCyc:PWY-981 is_a: GO:0009696 ! salicylic acid metabolic process -is_a: GO:0017000 ! antibiotic biosynthetic process -is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process @@ -96980,7 +97249,6 @@ name: response to abscisic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl] synonym: "response to abscisic acid stimulus" EXACT [GOC:dos] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:0033993 ! response to lipid is_a: GO:0097305 ! response to alcohol @@ -97005,7 +97273,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl] synonym: "response to gibberellic acid stimulus" NARROW [] synonym: "response to gibberellin stimulus" EXACT [GOC:dos] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound @@ -97113,11 +97380,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl] synonym: "response to salicylate" EXACT [GOC:dph] synonym: "response to salicylic acid stimulus" EXACT [GOC:dos] -is_a: GO:0001101 ! response to acid chemical -is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] @@ -97135,7 +97398,6 @@ name: response to jasmonic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl] synonym: "response to jasmonic acid stimulus" EXACT [GOC:dos] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:1901700 ! response to oxygen-containing compound @@ -98462,8 +98724,6 @@ synonym: "red-sensitive opsin" NARROW [] synonym: "short-wave-sensitive opsin" NARROW [] synonym: "UV-sensitive opsin" NARROW [] synonym: "violet-sensitive opsin" NARROW [] -xref: Reactome:R-HSA-2465917 "Photons induce isomerisation of 11c-retinyl to at-retinyl" -xref: Reactome:R-HSA-74101 "Photons induce isomerization of 11c-retinyl to at-retinyl" is_a: GO:0038023 ! signaling receptor activity [Term] @@ -99483,6 +99743,7 @@ namespace: molecular_function def: "Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [MetaCyc:RXN-5962, PMID:8837513] xref: EC:1.14.99 xref: MetaCyc:RXN-5962 +xref: RHEA:57352 is_a: GO:0072374 ! carotene epsilon hydroxylase activity [Term] @@ -99523,6 +99784,7 @@ synonym: "HPI" RELATED [EC:4.2.1.92] synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] xref: MetaCyc:RXN1F-19 +xref: RHEA:25074 is_a: GO:0016836 ! hydro-lyase activity [Term] @@ -99544,8 +99806,6 @@ synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11] synonym: "glutamate carboxypeptidase activity" EXACT [] synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11] synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11] -xref: EC:3.4.17.11 -xref: MetaCyc:3.4.17.11-RXN is_obsolete: true replaced_by: GO:0004180 @@ -99948,7 +100208,6 @@ synonym: "proanthocyanidin formation" EXACT [] synonym: "proanthocyanidin synthesis" EXACT [] xref: MetaCyc:PWY-641 is_a: GO:0009699 ! phenylpropanoid biosynthetic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process @@ -99962,7 +100221,6 @@ synonym: "phytochromobilin biosynthesis" EXACT [] synonym: "phytochromobilin formation" EXACT [] synonym: "phytochromobilin synthesis" EXACT [] is_a: GO:0033014 ! tetrapyrrole biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0051202 ! phytochromobilin metabolic process [Term] @@ -100065,9 +100323,7 @@ id: GO:0010034 name: response to acetate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010033 ! response to organic substance -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] @@ -100091,7 +100347,6 @@ name: response to carbon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm] is_a: GO:0010033 ! response to organic substance -is_a: GO:0072347 ! response to anesthetic is_a: GO:1901700 ! response to oxygen-containing compound [Term] @@ -100957,8 +101212,6 @@ synonym: "phenylacetate breakdown" EXACT [] synonym: "phenylacetate catabolism" EXACT [] synonym: "phenylacetate degradation" EXACT [] xref: MetaCyc:PWY0-321 -is_a: GO:0009407 ! toxin catabolic process -is_a: GO:0009852 ! auxin catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -100978,7 +101231,6 @@ xref: MetaCyc:PWY1G-0 is_a: GO:0010126 ! mycothiol metabolic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0010126 @@ -100988,7 +101240,6 @@ def: "The chemical reactions and pathways involving mycothiol, which consists of synonym: "mycothiol metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0016137 ! glycoside metabolic process -is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0010127 @@ -101332,7 +101583,6 @@ id: GO:0010157 name: response to chlorate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound @@ -101416,7 +101666,6 @@ id: GO:0010167 name: response to nitrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound @@ -101477,6 +101726,7 @@ namespace: molecular_function def: "Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol." [MetaCyc:RXN-2541, PMID:14512521] xref: KEGG_REACTION:R07500 xref: MetaCyc:RXN-2541 +xref: RHEA:37975 is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] @@ -101520,7 +101770,6 @@ def: "Interacting selectively and non-covalently with flavin mono nucleotide. Fl synonym: "flavin mononucleotide binding" EXACT [] is_a: GO:0032553 ! ribonucleotide binding is_a: GO:0043168 ! anion binding -is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0010182 @@ -101652,10 +101901,7 @@ name: response to ozone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm] is_a: GO:0000302 ! response to reactive oxygen species -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic [Term] id: GO:0010194 @@ -101723,7 +101969,6 @@ name: response to chitin namespace: biological_process def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm] is_a: GO:0010243 ! response to organonitrogen compound -is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound [Term] @@ -102111,6 +102356,7 @@ def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxyg synonym: "photosynthetic water oxidation" EXACT [] xref: MetaCyc:PSII-RXN xref: MetaCyc:RXN0-5265 +xref: RHEA:36359 is_a: GO:0016491 ! oxidoreductase activity [Term] @@ -102321,7 +102567,6 @@ synonym: "response to thiamine" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin -is_a: GO:0042493 ! response to drug [Term] id: GO:0010267 @@ -102402,6 +102647,7 @@ namespace: molecular_function def: "Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+." [MetaCyc:RXN-7683] xref: EC:2.7.1 xref: MetaCyc:RXN-7683 +xref: RHEA:38055 is_a: GO:0016301 ! kinase activity [Term] @@ -102576,6 +102822,7 @@ name: abscisic acid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062] xref: MetaCyc:RXN-8155 +xref: RHEA:31031 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -102601,6 +102848,7 @@ namespace: molecular_function def: "Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+." [MetaCyc:RXN-8409, PMID:16870359] xref: EC:3.1.1 xref: MetaCyc:RXN-8409 +xref: RHEA:48520 is_a: GO:0051723 ! protein methylesterase activity [Term] @@ -102617,6 +102865,7 @@ name: dihydrocamalexic acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+." [MetaCyc:RXN-8275, PMID:16766671] xref: MetaCyc:RXN-8275 +xref: RHEA:34807 is_a: GO:0016831 ! carboxy-lyase activity [Term] @@ -102730,7 +102979,6 @@ name: regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119] synonym: "regulation of hydrogen peroxide metabolism" EXACT [] -is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042743 ! hydrogen peroxide metabolic process @@ -102989,7 +103237,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119] synonym: "regulation of salicylic acid metabolism" RELATED [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process -is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009696 ! salicylic acid metabolic process relationship: regulates GO:0009696 ! salicylic acid metabolic process @@ -103079,6 +103326,7 @@ name: L-galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667] xref: MetaCyc:RXNQT-4142 +xref: RHEA:26349 is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity [Term] @@ -103097,6 +103345,7 @@ namespace: molecular_function def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629] synonym: "L-galactose 1-dehydrogenase activity" RELATED [] xref: MetaCyc:RXN-1884 +xref: RHEA:31559 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] @@ -103234,8 +103483,8 @@ id: GO:0010364 name: regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators] +is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process -is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:1900911 ! regulation of olefin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009693 ! ethylene biosynthetic process @@ -103247,8 +103496,8 @@ name: positive regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process -is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:1900913 ! positive regulation of olefin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0009693 ! ethylene biosynthetic process @@ -103260,8 +103509,8 @@ name: negative regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process -is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:1900912 ! negative regulation of olefin biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009693 ! ethylene biosynthetic process @@ -103309,8 +103558,8 @@ def: "Any process that modulates the frequency, rate or extent of the chemical r synonym: "regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process -is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009686 ! gibberellin biosynthetic process @@ -103323,8 +103572,8 @@ namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "positive regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process -is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process @@ -103338,7 +103587,7 @@ namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process -is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process @@ -103480,7 +103729,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators] synonym: "glucomannan metabolism" EXACT [] is_a: GO:0006080 ! substituted mannan metabolic process -is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0010392 @@ -105227,7 +105475,6 @@ namespace: biological_process def: "The controlled release of glutamine by a cell." [PMID:15208395] is_a: GO:0006868 ! glutamine transport is_a: GO:0032940 ! secretion by cell -is_a: GO:0046717 ! acid secretion [Term] id: GO:0010586 @@ -106729,7 +106976,6 @@ namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process @@ -106742,7 +106988,6 @@ namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process @@ -107445,7 +107690,6 @@ name: regulation of ubiquinone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb] is_a: GO:0010566 ! regulation of ketone biosynthetic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006744 ! ubiquinone biosynthetic process relationship: regulates GO:0006744 ! ubiquinone biosynthetic process @@ -107623,7 +107867,6 @@ id: GO:0010815 name: bradykinin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:BHF, GOC:rl] -is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process [Term] @@ -107633,7 +107876,6 @@ namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl] is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042447 ! hormone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process [Term] @@ -109016,7 +109258,8 @@ is_a: GO:0045892 ! negative regulation of transcription, DNA-templated id: GO:0010945 name: CoA pyrophosphatase activity namespace: molecular_function -def: "Catalysis of the reaction: coenzyme A + H2O = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb] +def: "Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb, PMID:10922370, PMID:16185196] +synonym: "conezyme A pyrophosphatase activity" RELATED [] is_a: GO:0016462 ! pyrophosphatase activity created_by: tb creation_date: 2009-04-22T02:06:40Z @@ -109148,7 +109391,6 @@ name: negative regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010957 ! negative regulation of vitamin D biosynthetic process -is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process @@ -109239,7 +109481,6 @@ name: regulation of L-arginine import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:dph, GOC:tb] is_a: GO:0051955 ! regulation of amino acid transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902023 ! L-arginine transport relationship: regulates GO:1902023 ! L-arginine transport @@ -110306,7 +110547,6 @@ def: "The controlled release of glutamate by a cell. The glutamate is the most a is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032940 ! secretion by cell -is_a: GO:0046717 ! acid secretion [Term] id: GO:0014048 @@ -110368,7 +110608,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "regulation of GABA secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion -is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014051 ! gamma-aminobutyric acid secretion @@ -110386,7 +110625,6 @@ synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW [] synonym: "negative regulation of GABA secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0051048 ! negative regulation of secretion -is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:0051956 ! negative regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion @@ -110405,7 +110643,6 @@ synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0051047 ! positive regulation of secretion -is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:0051957 ! positive regulation of amino acid transport intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion @@ -110431,7 +110668,6 @@ is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0043269 ! regulation of ion transport is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051952 ! regulation of amine transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014055 ! acetylcholine secretion, neurotransmission relationship: regulates GO:0014055 ! acetylcholine secretion, neurotransmission @@ -110451,7 +110687,6 @@ is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051954 ! positive regulation of amine transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission relationship: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission @@ -110470,7 +110705,6 @@ is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051953 ! negative regulation of amine transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission relationship: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission @@ -110484,7 +110718,6 @@ is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0043269 ! regulation of ion transport is_a: GO:0050433 ! regulation of catecholamine secretion -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014046 ! dopamine secretion relationship: regulates GO:0014046 ! dopamine secretion @@ -110522,7 +110755,6 @@ synonym: "regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0043269 ! regulation of ion transport -is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:1903530 ! regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001820 ! serotonin secretion @@ -110542,7 +110774,6 @@ is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0043271 ! negative regulation of ion transport -is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:1903531 ! negative regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001820 ! serotonin secretion @@ -110563,7 +110794,6 @@ is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0043270 ! positive regulation of ion transport -is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903532 ! positive regulation of secretion by cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001820 ! serotonin secretion @@ -110714,7 +110944,6 @@ comment: Note that this term is in the subset of terms that should not be used f subset: gocheck_do_not_manually_annotate synonym: "response to selective serotonin reuptake inhibitor" RELATED [] synonym: "response to SSRI" RELATED [] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0036276 ! response to antidepressant [Term] @@ -111373,7 +111602,7 @@ name: artery smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MSH:D001158] is_a: GO:0014820 ! tonic smooth muscle contraction -is_a: GO:0014829 ! vascular smooth muscle contraction +is_a: GO:0014829 ! vascular associated smooth muscle contraction [Term] id: GO:0014825 @@ -111388,7 +111617,7 @@ name: vein smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MSH:D014680] is_a: GO:0014821 ! phasic smooth muscle contraction -is_a: GO:0014829 ! vascular smooth muscle contraction +is_a: GO:0014829 ! vascular associated smooth muscle contraction [Term] id: GO:0014827 @@ -111408,9 +111637,10 @@ is_a: GO:0120063 ! stomach smooth muscle contraction [Term] id: GO:0014829 -name: vascular smooth muscle contraction +name: vascular associated smooth muscle contraction namespace: biological_process def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718] +synonym: "vascular smooth muscle contraction" EXACT [] is_a: GO:0006939 ! smooth muscle contraction is_a: GO:0042310 ! vasoconstriction @@ -112227,7 +112457,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732] synonym: "corrin metabolism" EXACT [] is_a: GO:0033013 ! tetrapyrrole metabolic process -is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0015010 @@ -112244,7 +112473,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, Wikipedia:Cofactor_F430] synonym: "coenzyme F430 metabolic process" NARROW [] synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process [Term] @@ -112342,6 +112570,7 @@ synonym: "PAPS:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] xref: EC:2.8.2.8 xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-2022860 "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)" +xref: RHEA:21980 is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] @@ -112367,6 +112596,7 @@ xref: MetaCyc:2.4.1.135-RXN xref: Reactome:R-HSA-1889955 "B3GAT dimers transfer GlcA to tetrasaccharide linker" xref: Reactome:R-HSA-3560802 "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker" xref: Reactome:R-HSA-9638064 "B3GAT3 dimer transfers GlcA to tetrasaccharide linker" +xref: RHEA:24168 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] @@ -112383,6 +112613,7 @@ xref: Reactome:R-HSA-1678660 "HGSNAT oligomer acetylates Heparan sulfate chain(3 xref: Reactome:R-HSA-2090085 "HGSNAT oligomer acetylates Heparan chain(1)" xref: Reactome:R-HSA-2263492 "Defective HGSNAT does not acetylate Heparan chain(1)" xref: Reactome:R-HSA-9036056 "Defective HGSNAT does not acetylate Heparan sulfate chain(3)" +xref: RHEA:15125 is_a: GO:0008080 ! N-acetyltransferase activity [Term] @@ -112463,6 +112694,7 @@ xref: Reactome:R-HSA-9036104 "Defective UGT1A4 does not transfer GlcA from UDP-G xref: Reactome:R-HSA-9632038 "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG" xref: Reactome:R-HSA-9632039 "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG" xref: Reactome:R-HSA-9638097 "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA" +xref: RHEA:21032 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -112643,6 +112875,7 @@ synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd] synonym: "NADPH:adrenodoxin oxidoreductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.6 xref: MetaCyc:RXN-13685 +xref: RHEA:42312 is_a: GO:0016491 ! oxidoreductase activity [Term] @@ -112699,7 +112932,7 @@ is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as a id: GO:0015044 name: rubredoxin-NAD+ reductase activity namespace: molecular_function -def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1] +def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1, RHEA:18597] synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "DPNH-rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "NADH--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] @@ -112712,6 +112945,7 @@ synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" EXAC synonym: "rubredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.1] xref: EC:1.18.1.1 xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN +xref: RHEA:18597 is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity [Term] @@ -112732,10 +112966,11 @@ is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as do [Term] id: GO:0015046 -name: rubredoxin-NADP reductase activity +name: rubredoxin-NADP+ reductase activity namespace: molecular_function -def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [EC:1.18.1.-] +def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [RHEA:13949] xref: EC:1.18.1 +xref: RHEA:13949 is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity [Term] @@ -112748,6 +112983,7 @@ synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" EXACT [EC:1.6.2.5] synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.6.2.5] xref: EC:1.6.2.5 xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN +xref: RHEA:15237 is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] @@ -113321,6 +113557,7 @@ name: bicarbonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] xref: Reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region" +xref: RHEA:28695 is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:0015701 ! bicarbonate transport @@ -113424,6 +113661,7 @@ synonym: "sulphate transporter activity" EXACT [] xref: Reactome:R-HSA-3560789 "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol" xref: Reactome:R-HSA-427555 "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol" xref: Reactome:R-HSA-8875871 "SLC26A11 transports SO4(2-) from extracellular region to cytosol" +xref: RHEA:34983 is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:1902358 ! sulfate transmembrane transport @@ -113495,8 +113733,8 @@ def: "Enables the transfer of bile acid from one side of a membrane to the other xref: Reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol" xref: Reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol" xref: Reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A" -xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport ALB:(GCCA,TCCA) from extracellular region to cytosol" -xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport ALB:(GCCA, TCCA) from extracellular region to cytosol" +xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" +xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" is_a: GO:0005319 ! lipid transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity @@ -113517,6 +113755,7 @@ namespace: molecular_function def: "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684] xref: Reactome:R-HSA-5679031 "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region" xref: Reactome:R-HSA-5679041 "ABCC2 transports BMG,BDG from cytosol to extracellular region" +xref: Reactome:R-HSA-9661417 "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity relationship: part_of GO:0015723 ! bilirubin transport @@ -114072,7 +114311,6 @@ def: "Enables the transfer of L-aspartate from one side of a membrane to the oth synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-aspartate transporter activity" BROAD [] -is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity @@ -114100,7 +114338,6 @@ synonym: "4-aminobutanoate transporter activity" EXACT [] synonym: "4-aminobutyrate transporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "GABA transporter activity" EXACT [] -is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:0015812 ! gamma-aminobutyric acid transport @@ -114124,7 +114361,6 @@ def: "Enables the transfer of glycine from one side of a membrane to the other. synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "glycine transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] -is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity @@ -114312,6 +114548,7 @@ namespace: molecular_function def: "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators] xref: Reactome:R-HSA-163215 "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane" xref: Reactome:R-HSA-5672027 "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane" +xref: RHEA:34999 is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity relationship: part_of GO:0015853 ! adenine transport @@ -114430,7 +114667,6 @@ xref: Reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellula xref: Reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol" xref: Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix" -is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity relationship: part_of GO:0015871 ! choline transport @@ -114454,7 +114690,6 @@ comment: This term was made obsolete because it was replaced by more specific te synonym: "vitamin or cofactor transporter activity" EXACT [] synonym: "vitamin/cofactor transporter activity" EXACT [] is_obsolete: true -consider: GO:0051184 consider: GO:0090482 [Term] @@ -114463,7 +114698,7 @@ name: biopterin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732] synonym: "biopterin transporter activity" RELATED [] -is_a: GO:0051185 ! coenzyme transmembrane transporter activity +is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015877 ! biopterin transport [Term] @@ -114478,7 +114713,6 @@ synonym: "vitamin H transporter activity" RELATED [] xref: RHEA:28458 is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity -is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0015878 ! biotin transport @@ -114516,7 +114750,6 @@ namespace: molecular_function def: "Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] synonym: "coenzyme A transporter activity" BROAD [] is_a: GO:0008514 ! organic anion transmembrane transporter activity -is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity relationship: part_of GO:0035349 ! coenzyme A transmembrane transport @@ -114527,10 +114760,9 @@ namespace: molecular_function def: "Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ISBN:0198506732] synonym: "L-ascorbate transporter activity" EXACT [] synonym: "vitamin C transporter activity" EXACT [] -xref: Reactome:R-HSA-198870 "SVCT1/2 cotransports extracellular VitC and 2Na+ to cytosol" +xref: Reactome:R-HSA-198870 "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol" is_a: GO:0015145 ! monosaccharide transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity -is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0015882 ! L-ascorbic acid transmembrane transport @@ -114548,7 +114780,6 @@ synonym: "flavin-adenine dinucleotide carrier activity" RELATED [] synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015215 ! nucleotide transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity relationship: part_of GO:0035350 ! FAD transmembrane transport [Term] @@ -114564,18 +114795,17 @@ relationship: part_of GO:0015885 ! 5-formyltetrahydrofolate transport [Term] id: GO:0015232 -name: heme transporter activity +name: heme transmembrane transporter activity namespace: molecular_function -def: "Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells." [GOC:ai] +def: "Enables the transfer of heme from one side of a membrane to the other." [PMID:29549126] synonym: "haem transporter activity" EXACT [] -xref: Reactome:R-HSA-1369065 "ABCB6 transports porphyrin from cytosol to mitchondrial matrix" -xref: Reactome:R-HSA-382560 "ABC7, mABC1 and mABC2 mediate heme transport" -xref: Reactome:R-HSA-5683355 "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix" +synonym: "heme transporter activity" BROAD [] xref: Reactome:R-HSA-917870 "SLC46A1 transports FeHM from extracellular region to cytosol" -xref: Reactome:R-HSA-917892 "FLVCR transports heme from cytosol to extracellular region" -xref: Reactome:R-HSA-917979 "ABCG2 dimer transports heme from cytosol to extracellular region" -is_a: GO:0051184 ! cofactor transmembrane transporter activity +xref: Reactome:R-HSA-917892 "FLVCR1-1 transports heme from cytosol to extracellular region" +xref: Reactome:R-HSA-9661408 "FLVCR1-2 transports heme from mitochondrial matrix to cytosol" +is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0015886 ! heme transport +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19472 xsd:anyURI [Term] id: GO:0015233 @@ -114586,7 +114816,6 @@ synonym: "pantothenate transporter activity" BROAD [GOC:mah] synonym: "vitamin B5 transmembrane transporter activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity -is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0015887 ! pantothenate transmembrane transport @@ -114605,6 +114834,7 @@ synonym: "thiamine permease activity" EXACT [] synonym: "thiamine uptake transmembrane transporter activity" RELATED [] synonym: "vitamin B1 transporter activity" EXACT [] xref: Reactome:R-HSA-199626 "SLC19A2/3 transport extracellular THMN to cytosol" +xref: RHEA:34919 is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity @@ -114637,7 +114867,6 @@ namespace: molecular_function def: "Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators] synonym: "fluconazole transporter activity" RELATED [] is_a: GO:0015665 ! alcohol transmembrane transporter activity -is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity relationship: part_of GO:0015903 ! fluconazole transport @@ -114653,6 +114882,7 @@ synonym: "fatty-acyl group transporter activity" BROAD [] synonym: "peroxisomal fatty acyl transporter" NARROW [] xref: Reactome:R-HSA-5627891 "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol" xref: Reactome:R-HSA-879585 "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol" +xref: RHEA:33655 is_a: GO:0005319 ! lipid transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity relationship: part_of GO:0015908 ! fatty acid transport @@ -114679,6 +114909,7 @@ xref: Reactome:R-HSA-5679101 "Defective ABCG8 (in ABCG5:ABCG8) does not transpor xref: Reactome:R-HSA-5679145 "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region" xref: Reactome:R-HSA-8867667 "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane" xref: Reactome:R-HSA-8868402 "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane" +xref: RHEA:39747 is_a: GO:0005319 ! lipid transporter activity relationship: part_of GO:0015918 ! sterol transport @@ -114695,6 +114926,7 @@ xref: Reactome:R-HSA-432067 "Aquaporin-4 passively transports water out of cell" xref: Reactome:R-HSA-445714 "Aquaporin-3 passively transports water out of cell" xref: Reactome:R-HSA-507868 "Aquaporins passively transport water into cells" xref: Reactome:R-HSA-507870 "Aquaporins passively transport water out of cells" +xref: RHEA:29667 is_a: GO:0005372 ! water transmembrane transporter activity is_a: GO:0015267 ! channel activity @@ -114735,6 +114967,7 @@ xref: Reactome:R-HSA-432049 "Aquaporin-9 passively transports glycerol into cell xref: Reactome:R-HSA-432074 "Aquaporin-7 passively transports glycerol out of cell" xref: Reactome:R-HSA-507869 "Aquaporins passively transport glycerol into cells" xref: Reactome:R-HSA-507871 "Aquaporins passively transport glycerol out of cells" +xref: RHEA:29675 is_a: GO:0015168 ! glycerol transmembrane transporter activity is_a: GO:0015267 ! channel activity @@ -114856,6 +115089,7 @@ synonym: "pore class transporter activity" RELATED [] synonym: "substrate-specific channel activity" RELATED [] xref: Reactome:R-HSA-3779381 "H2O2 diffuses from the mitochondrial matrix to the cytosol" xref: Reactome:R-HSA-8953430 "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix" +xref: RHEA:29447 xref: TC:1 is_a: GO:0022803 ! passive transmembrane transporter activity @@ -114907,7 +115141,7 @@ def: "Enables the transmembrane transfer of an ion by a channel that opens when synonym: "ionotropic receptor activity" NARROW [GOC:bf, GOC:sart] xref: Reactome:R-HSA-451310 "Activation of Edited Kainate receptors" xref: Reactome:R-HSA-451311 "Activation of Ca-permeable Kainate receptors" -xref: Reactome:R-HSA-622325 "Activation of highly sodium permeable nicotinic acetylcholine receptors" +xref: Reactome:R-HSA-622325 "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors" xref: Reactome:R-HSA-622326 "Activation of highly calcium permeable nicotinic acetylcholine receptors" xref: Reactome:R-HSA-629595 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors" is_a: GO:0005216 ! ion channel activity @@ -115120,6 +115354,9 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] synonym: "solute:hydrogen antiporter activity" EXACT [] +xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics" +xref: Reactome:R-HSA-5625574 "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+" +xref: Reactome:R-HSA-597628 "SLC22A18 exchanges extracellular organic cations for cytosolic H+" is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0015298 ! solute:cation antiporter activity @@ -115179,6 +115416,7 @@ synonym: "sialate transporter activity" BROAD [] synonym: "sialate/cation symporter activity" EXACT [] is_a: GO:0015136 ! sialic acid transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity [Term] id: GO:0015307 @@ -115188,9 +115426,6 @@ def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a m comment: This term was obsoleted because it is not possible to state that every case of transmembrane transport for a specific chemical constitutes a drug transport. synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] synonym: "drug:hydrogen antiporter activity" EXACT [] -xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics" -xref: Reactome:R-HSA-5625574 "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+" -xref: Reactome:R-HSA-597628 "SLC22A18 exchanges extracellular organic cations for cytosolic H+" is_obsolete: true [Term] @@ -115408,6 +115643,7 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to synonym: "peptide:hydrogen symporter activity" EXACT [] xref: Reactome:R-HSA-427998 "Proton-coupled di- and tri-peptide cotransport" xref: Reactome:R-HSA-428007 "Proton-coupled histidine and di-peptide cotransport" +xref: RHEA:37047 is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity @@ -115535,7 +115771,7 @@ synonym: "ferric-enterobactin:proton symporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015603 ! iron chelate transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity +is_a: GO:0042971 ! lactone transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] @@ -115558,6 +115794,10 @@ xref: Reactome:R-HSA-561059 "OAT2 and OAT4 mediate transport of sulphate conjuga xref: Reactome:R-HSA-879562 "SLCO2B1 has a narrow substrate specificity" xref: Reactome:R-HSA-879584 "SLCO3A1 isoform 1 has abroad substrate specificity" xref: Reactome:R-HSA-879594 "SLCO4C1 mediates the transport of digoxin" +xref: Reactome:R-HSA-9661397 "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)" +xref: Reactome:R-HSA-9661446 "BMG, BDG translocates from ER lumen to cytosol" +xref: Reactome:R-HSA-9661723 "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)" +xref: Reactome:R-HSA-9661799 "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022853 ! active ion transmembrane transporter activity @@ -115578,7 +115818,6 @@ id: GO:0015349 name: thyroid hormone transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai] -xref: Reactome:R-HSA-5661195 "Defective SLCO1B1 does not transport T3,T4 from extracellular region to cytosol" xref: Reactome:R-HSA-879575 "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol" xref: Reactome:R-HSA-9631987 "SLCO1B1 transports T3,T4 from extracellular region to cytosol" is_a: GO:0015291 ! secondary active transmembrane transporter activity @@ -115807,7 +116046,6 @@ def: "Enables the transfer of a solute or solutes from one side of a membrane to xref: Reactome:R-HSA-444120 "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol" xref: Reactome:R-HSA-5660840 "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol" is_a: GO:0005295 ! neutral amino acid:sodium symporter activity -is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015187 ! glycine transmembrane transporter activity [Term] @@ -116104,6 +116342,7 @@ xref: EC:7.6.2.7 xref: MetaCyc:3.6.3.36-RXN xref: RHEA:14614 is_a: GO:0005368 ! taurine transmembrane transporter activity +is_a: GO:0008559 ! ATPase-coupled xenobiotic transmembrane transporter activity is_a: GO:0033283 ! ATPase-coupled organic acid transmembrane transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity @@ -116274,14 +116513,12 @@ synonym: "vitamin B12-transporting ATPase activity" BROAD [] xref: EC:7.6.2.8 xref: MetaCyc:3.6.3.33-RXN xref: MetaCyc:ABC-5-RXN -xref: Reactome:R-HSA-3000122 "CD320 transports extracellular TCII:Cbl to endosome" xref: Reactome:R-HSA-3000238 "LMBRD1 transports lysosomal Cbl to cytosol" xref: Reactome:R-HSA-3095901 "ABCC1 transports cytosolic Cbl to extracellular region" xref: Reactome:R-HSA-3315437 "Defective LMBRD1 does not transport lysosomal Cbl to cytosol" xref: RHEA:17873 xref: RHEA:32831 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0015889 ! cobalamin transport @@ -116298,6 +116535,7 @@ synonym: "oligopeptide-transporting ATPase activity" EXACT [EC:7.4.2.6] xref: EC:7.4.2.6 xref: MetaCyc:3.6.3.23-RXN xref: Reactome:R-HSA-5223317 "ABCB9 transports peptides from cytosol to lysosomal lumen" +xref: RHEA:37271 is_a: GO:0015440 ! ATPase-coupled peptide transmembrane transporter activity is_a: GO:0035673 ! oligopeptide transmembrane transporter activity @@ -116383,6 +116621,7 @@ synonym: "polar-amino acid-transporting ATPase activity" EXACT [] synonym: "polar-amino-acid-transporting ATPase activity" EXACT [EC:7.4.2.1] xref: EC:7.4.2.1 xref: MetaCyc:3.6.3.21-RXN +xref: RHEA:14673 is_a: GO:0015424 ! ATPase-coupled amino acid transmembrane transporter activity [Term] @@ -116444,6 +116683,7 @@ synonym: "glutathione S-conjugate-transporting ATPase activity" RELATED [EC:7.6. synonym: "GS-X pump" EXACT [] synonym: "MRP1/GS-X pump" EXACT [] xref: EC:7.6.2.3 +xref: RHEA:19121 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity created_by: mah @@ -116563,8 +116803,12 @@ synonym: "protoheme IX ABC transporter activity" RELATED [] xref: EC:7.6.2.5 xref: MetaCyc:3.6.3.41-RXN xref: MetaCyc:TRANS-RXN0-162 +xref: Reactome:R-HSA-1369065 "ABCB6 transports porphyrin from cytosol to mitchondrial matrix" +xref: Reactome:R-HSA-382560 "ABC7, mABC1 and mABC2 mediate heme transport" +xref: Reactome:R-HSA-5683355 "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix" +xref: Reactome:R-HSA-917979 "ABCG2 tetramer transports heme from cytosol to extracellular region" xref: RHEA:19261 -is_a: GO:0015232 ! heme transporter activity +is_a: GO:0015232 ! heme transmembrane transporter activity is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity relationship: part_of GO:0035351 ! heme transmembrane transport @@ -116579,6 +116823,7 @@ synonym: "peptide ABC transporter" NARROW [] synonym: "peptide-transporting ATPase activity" EXACT [] xref: EC:7.4.2.5 xref: MetaCyc:3.6.3.43-RXN +xref: RHEA:14429 is_a: GO:0033220 ! ATPase-coupled amide-transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity relationship: part_of GO:0015833 ! peptide transport @@ -117118,9 +117363,7 @@ name: pantothenate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1] is_a: GO:0042887 ! amide transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity -is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:0140161 ! monocarboxylate:sodium symporter activity relationship: part_of GO:0098719 ! sodium ion import across plasma membrane @@ -117355,9 +117598,9 @@ id: GO:0015527 name: glycerol-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3] -is_a: GO:0015114 ! phosphate ion transmembrane transporter activity -is_a: GO:0015168 ! glycerol transmembrane transporter activity -is_a: GO:0140323 ! solute:anion antiporter activity +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015528 @@ -117463,6 +117706,7 @@ synonym: "sialic acid permease activity" RELATED [] synonym: "sialic acid:hydrogen symporter activity" EXACT [] xref: Reactome:R-HSA-428585 "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol" xref: Reactome:R-HSA-5624239 "Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol" +xref: RHEA:28987 is_a: GO:0015136 ! sialic acid transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity @@ -117535,7 +117779,6 @@ def: "Enables the transfer of sulfathiazole from one side of a membrane to the o synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED [] synonym: "sulphathiazole transporter activity" EXACT [] is_a: GO:0042887 ! amide transmembrane transporter activity -is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:1902599 ! sulfathiazole transmembrane transport @@ -118001,6 +118244,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in)." [EC:3.6.3.17, TC:3.A.1.-.-] synonym: "D-ribose porter activity" BROAD [] xref: MetaCyc:ABC-28-RXN +xref: RHEA:29903 is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity is_a: GO:0015591 ! D-ribose transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity @@ -118012,6 +118256,7 @@ namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in)." [EC:3.6.3.17, TC:3.A.1.-.-] synonym: "L-arabinose porter activity" EXACT [] xref: MetaCyc:ABC-2-RXN +xref: RHEA:30007 is_a: GO:0015147 ! L-arabinose transmembrane transporter activity is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity @@ -118113,10 +118358,11 @@ synonym: "ferric-enterobactin ABC transporter" NARROW [] synonym: "ferric-enterobactin porter activity" BROAD [] synonym: "ferric-enterobactin-transporting ATPase activity" EXACT [] xref: MetaCyc:ABC-10-RXN +xref: RHEA:58492 is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015623 ! ATPase-coupled iron-chelate transporter activity is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity +is_a: GO:0042971 ! lactone transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] @@ -118423,6 +118669,7 @@ synonym: "branched-chain aliphatic amino acid transmembrane transporter activity synonym: "branched-chain aliphatic amino acid transporter activity" EXACT [] synonym: "leucine/valine/isoleucine permease activity" RELATED [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] +xref: Reactome:R-HSA-9672770 "SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix" is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:0015803 ! branched-chain amino acid transport @@ -118466,7 +118713,6 @@ def: "Enables the directed movement of nicotinamide mononucleotide into, out of synonym: "nicotinamide mononucleotide permease activity" RELATED [] synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT [] is_a: GO:0015215 ! nucleotide transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0035353 ! nicotinamide mononucleotide transmembrane transport @@ -118501,6 +118747,7 @@ synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" E synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" EXACT [EC:2.1.1.113] xref: EC:2.1.1.113 xref: MetaCyc:2.1.1.113-RXN +xref: RHEA:16857 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity relationship: part_of GO:0090124 ! N-4 methylation of cytosine @@ -118530,7 +118777,6 @@ name: carbon dioxide transport namespace: biological_process def: "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015669 ! gas transport -is_a: GO:0015893 ! drug transport is_a: GO:0019755 ! one-carbon compound transport [Term] @@ -118539,7 +118785,6 @@ name: oxygen transport namespace: biological_process def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015669 ! gas transport -is_a: GO:0015893 ! drug transport [Term] id: GO:0015672 @@ -118901,7 +119146,6 @@ namespace: biological_process def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "allantoin transmembrane transport" EXACT [GOC:mah] synonym: "allantoin/allantoate transport" BROAD [] -is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport @@ -118922,7 +119166,7 @@ name: canalicular bile acid transport namespace: biological_process def: "Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph] is_a: GO:0015721 ! bile acid and bile salt transport -is_a: GO:0046717 ! acid secretion +is_a: GO:0046903 ! secretion [Term] id: GO:0015723 @@ -118938,7 +119182,6 @@ name: formate transport namespace: biological_process def: "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport -is_a: GO:0015893 ! drug transport [Term] id: GO:0015726 @@ -118977,7 +119220,6 @@ name: propanoate transport namespace: biological_process def: "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "propionate transport" EXACT [] -is_a: GO:0015893 ! drug transport is_a: GO:0015912 ! short-chain fatty acid transport [Term] @@ -119093,7 +119335,6 @@ name: succinate transport namespace: biological_process def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015740 ! C4-dicarboxylate transport -is_a: GO:0015893 ! drug transport [Term] id: GO:0015745 @@ -119549,8 +119790,6 @@ def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionin synonym: "S-adenosyl methionine transport" EXACT [] synonym: "S-adenosylmethionine transport" EXACT [] synonym: "SAM transport" EXACT [] -is_a: GO:0015893 ! drug transport -is_a: GO:0051182 ! coenzyme transport is_a: GO:0071702 ! organic substance transport is_a: GO:0072348 ! sulfur compound transport @@ -119616,7 +119855,6 @@ comment: See also the biological process term 'neurotransmitter transport ; GO:0 synonym: "4-aminobutanoate transport" EXACT [] synonym: "4-aminobutyrate transport" EXACT [] synonym: "GABA transport" EXACT [] -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0006865 ! amino acid transport is_a: GO:0015718 ! monocarboxylic acid transport @@ -119629,8 +119867,6 @@ def: "The directed movement of L-glutamate across a membrane." [PMID:21307582] synonym: "L-glutamate transport" BROAD [] synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0006835 ! dicarboxylic acid transport -is_a: GO:0006836 ! neurotransmitter transport -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport @@ -119649,10 +119885,8 @@ name: glycine transport namespace: biological_process def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006812 ! cation transport -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0015807 ! L-amino acid transport -is_a: GO:0015893 ! drug transport [Term] id: GO:0015817 @@ -119997,7 +120231,6 @@ name: uracil transport namespace: biological_process def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015855 ! pyrimidine nucleobase transport -is_a: GO:0015893 ! drug transport [Term] id: GO:0015858 @@ -120080,7 +120313,6 @@ namespace: biological_process def: "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport -is_a: GO:0015893 ! drug transport is_a: GO:0051503 ! adenine nucleotide transport [Term] @@ -120106,9 +120338,7 @@ id: GO:0015870 name: acetylcholine transport namespace: biological_process def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015695 ! organic cation transport -is_a: GO:0015893 ! drug transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901374 ! acetate ester transport @@ -120117,7 +120347,6 @@ id: GO:0015871 name: choline transport namespace: biological_process def: "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015695 ! organic cation transport is_a: GO:0071705 ! nitrogen compound transport @@ -120127,7 +120356,6 @@ name: dopamine transport namespace: biological_process def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] is_a: GO:0006812 ! cation transport -is_a: GO:0015893 ! drug transport is_a: GO:0051937 ! catecholamine transport [Term] @@ -120148,7 +120376,6 @@ comment: This term was made obsolete because it was replaced by more specific te synonym: "vitamin or cofactor transport" EXACT [] is_obsolete: true consider: GO:0051180 -consider: GO:0051181 [Term] id: GO:0015876 @@ -120156,14 +120383,12 @@ name: acetyl-CoA transport namespace: biological_process def: "The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] is_a: GO:0015916 ! fatty-acyl-CoA transport -is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0015877 name: biopterin transport namespace: biological_process def: "The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai] -is_a: GO:0051182 ! coenzyme transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport @@ -120175,10 +120400,8 @@ def: "The directed movement of biotin into, out of or within a cell, or between synonym: "vitamin B7 transport" EXACT [] synonym: "vitamin H transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport -is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0051180 ! vitamin transport -is_a: GO:0051182 ! coenzyme transport is_a: GO:0072348 ! sulfur compound transport [Term] @@ -120196,7 +120419,6 @@ namespace: biological_process def: "The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport -is_a: GO:0051182 ! coenzyme transport is_a: GO:0051503 ! adenine nucleotide transport [Term] @@ -120206,7 +120428,6 @@ namespace: biological_process alt_id: GO:1902598 def: "The directed movement of creatine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "creatine transport" BROAD [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport @@ -120223,7 +120444,6 @@ synonym: "L-ascorbic acid transport" RELATED [] synonym: "vitamin C transport" EXACT [] is_a: GO:0015749 ! monosaccharide transmembrane transport is_a: GO:0035461 ! vitamin transmembrane transport -is_a: GO:0051182 ! coenzyme transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] @@ -120235,7 +120455,6 @@ synonym: "flavin adenine dinucleotide transport" EXACT [] synonym: "flavin-adenine dinucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0015711 ! organic anion transport -is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0015884 @@ -120246,10 +120465,8 @@ synonym: "folate transport" EXACT [] synonym: "vitamin B9 transport" EXACT [] synonym: "vitamin M transport" EXACT [] is_a: GO:0006835 ! dicarboxylic acid transport -is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0051180 ! vitamin transport -is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport [Term] @@ -120259,7 +120476,6 @@ namespace: biological_process def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0042886 ! amide transport -is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport [Term] @@ -120268,7 +120484,6 @@ name: heme transport namespace: biological_process def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "haem transport" EXACT [] -is_a: GO:0051181 ! cofactor transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901678 ! iron coordination entity transport @@ -120285,7 +120500,6 @@ synonym: "vitamin B5 transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0042886 ! amide transport -is_a: GO:0051182 ! coenzyme transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport @@ -120296,7 +120510,6 @@ namespace: biological_process def: "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai] synonym: "thiamin transport" EXACT [] synonym: "vitamin B1 transport" EXACT [] -is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport @@ -120308,9 +120521,7 @@ name: cobalamin transport namespace: biological_process def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "vitamin B12 transport" EXACT [] -is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport -is_a: GO:0051181 ! cofactor transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport @@ -120321,7 +120532,6 @@ namespace: biological_process def: "The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [ISBN:0721662544] synonym: "nicotinamide ribonucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport -is_a: GO:0051181 ! cofactor transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] @@ -120354,7 +120564,6 @@ def: "The directed movement of acriflavine into, out of or within a cell, or bet synonym: "acriflavin transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0006821 ! chloride transport is_a: GO:0015695 ! organic cation transport -is_a: GO:0015893 ! drug transport is_a: GO:0042908 ! xenobiotic transport [Term] @@ -120370,7 +120579,6 @@ name: nalidixic acid transport namespace: biological_process def: "The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221] is_a: GO:0015718 ! monocarboxylic acid transport -is_a: GO:0015893 ! drug transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0071705 ! nitrogen compound transport @@ -120404,7 +120612,6 @@ id: GO:0015900 name: benomyl transport namespace: biological_process def: "The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [GOC:curators] -is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0071702 ! organic substance transport @@ -120415,7 +120622,6 @@ name: cycloheximide transport namespace: biological_process def: "The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732] is_a: GO:0015850 ! organic hydroxy compound transport -is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport [Term] @@ -120434,7 +120640,6 @@ name: fluconazole transport namespace: biological_process def: "The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators] is_a: GO:0015850 ! organic hydroxy compound transport -is_a: GO:0015893 ! drug transport is_a: GO:0071705 ! nitrogen compound transport [Term] @@ -120444,7 +120649,6 @@ namespace: biological_process def: "The directed movement of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:curators] synonym: "tetracyclin transport" BROAD [] synonym: "tetracycline transport" BROAD [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0098656 ! anion transmembrane transport @@ -120455,7 +120659,7 @@ name: bicyclomycin transmembrane transport namespace: biological_process def: "The directed movement of bicyclomycin across a lipid bilayer, from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [PMID:20067529] synonym: "bicyclomycin transport" BROAD [] -is_a: GO:0006855 ! drug transmembrane transport +is_a: GO:0055085 ! transmembrane transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport @@ -120625,6 +120829,7 @@ name: trehalase activity namespace: molecular_function def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai] xref: MetaCyc:TREHALA-RXN +xref: RHEA:32675 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -120704,7 +120909,6 @@ alt_id: GO:0006763 def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] synonym: "CoA metabolism" EXACT [] synonym: "coenzyme A metabolism" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process @@ -120723,7 +120927,6 @@ synonym: "coenzyme A synthesis" EXACT [] xref: MetaCyc:COA-PWY xref: MetaCyc:PANTOSYN-PWY xref: MetaCyc:PWY-4221 -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0015936 ! coenzyme A metabolic process is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process @@ -120739,7 +120942,6 @@ synonym: "CoA catabolism" EXACT [] synonym: "coenzyme A breakdown" EXACT [] synonym: "coenzyme A catabolism" EXACT [] synonym: "coenzyme A degradation" EXACT [] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0015936 ! coenzyme A metabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process @@ -120755,7 +120957,6 @@ synonym: "pantothenate metabolism" EXACT [] synonym: "vitamin B5 metabolic process" EXACT [] synonym: "vitamin B5 metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process @@ -120788,7 +120989,6 @@ xref: MetaCyc:PANTO-PWY xref: MetaCyc:PANTOSYN-PWY xref: MetaCyc:PWY-3961 xref: MetaCyc:PWY-4221 -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0015939 ! pantothenate metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process @@ -120805,7 +121005,6 @@ synonym: "pantothenate catabolism" EXACT [] synonym: "pantothenate degradation" EXACT [] synonym: "vitamin B5 catabolic process" EXACT [] synonym: "vitamin B5 catabolism" EXACT [] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0015939 ! pantothenate metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process @@ -120817,7 +121016,6 @@ name: formate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732] synonym: "formate metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] @@ -120832,7 +121030,6 @@ synonym: "formate synthesis" EXACT [] synonym: "formic acid biosynthesis" EXACT [] synonym: "formic acid biosynthetic process" EXACT [] is_a: GO:0015942 ! formate metabolic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] @@ -121371,7 +121568,7 @@ is_obsolete: true id: GO:0016002 name: sulfite reductase activity namespace: molecular_function -def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [RHEA:10547] +def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [GOC:curators] synonym: "assimilatory sulfite reductase activity" EXACT [] synonym: "assimilatory-type sulfite reductase activity" EXACT [] synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [] @@ -121379,7 +121576,6 @@ synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [] synonym: "siroheme sulfite reductase activity" NARROW [MetaCyc:SULFITE-REDUCTASE-RXN] synonym: "sulphite reductase activity" EXACT [] xref: MetaCyc:SULFITE-REDUCTASE-RXN -xref: RHEA:10547 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] @@ -121549,7 +121745,6 @@ synonym: "CDP-diacylglycerol anabolism" EXACT [] synonym: "CDP-diacylglycerol biosynthesis" EXACT [] synonym: "CDP-diacylglycerol formation" EXACT [] synonym: "CDP-diacylglycerol synthesis" EXACT [] -is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0046341 ! CDP-diacylglycerol metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process @@ -121719,6 +121914,7 @@ synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" EXACT [EC:1.4. xref: EC:1.4.7.1 xref: MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN xref: MetaCyc:PWY-4341 +xref: RHEA:12128 is_a: GO:0015930 ! glutamate synthase activity is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor @@ -123072,6 +123268,7 @@ synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activit synonym: "vanadium-iron nitrogenase activity" NARROW [] xref: EC:1.18.6.1 xref: MetaCyc:NITROGENASE-RXN +xref: RHEA:21448 xref: UM-BBD_enzymeID:e0395 is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor @@ -123128,7 +123325,6 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] is_a: GO:0043168 ! anion binding is_a: GO:0046906 ! tetrapyrrole binding -is_a: GO:0048037 ! cofactor binding property_value: RO:0002161 NCBITaxon:33208 [Term] @@ -123216,6 +123412,7 @@ xref: Reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from ox xref: Reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen" xref: Reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen" xref: Reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-" +xref: Reactome:R-HSA-9673797 "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen" is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [Term] @@ -123446,7 +123643,7 @@ synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1 xref: EC:2.1.1.6 xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-175983 "COMT transfer CH3 from AdoMet to 3,4DHBNZ" -xref: Reactome:R-HSA-8955010 "LRTOMT transfers methyl group from AdoMet to DA, forming 3MT" +xref: Reactome:R-HSA-8955010 "LRTOMT transfers Met to DA, forming 3MT" is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity property_value: RO:0002161 NCBITaxon:4890 @@ -123488,7 +123685,6 @@ id: GO:0016208 name: AMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators] -is_a: GO:0008144 ! drug binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0043168 ! anion binding is_a: GO:0043169 ! cation binding @@ -123651,11 +123847,11 @@ name: iron-sulfur cluster assembly namespace: biological_process def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] subset: goslim_metagenomics +subset: goslim_pombe synonym: "iron-sulfur cluster biosynthesis" RELATED [] synonym: "iron-sulphur cluster assembly" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0031163 ! metallo-sulfur cluster assembly -is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0016227 @@ -123671,8 +123867,6 @@ synonym: "transfer RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer RNA thiolase activity" EXACT [EC:2.8.1.4] synonym: "tRNA sulfurtransferase activity" EXACT [] synonym: "tRNA sulphurtransferase activity" EXACT [] -xref: EC:2.8.1.4 -xref: MetaCyc:TRNA-S-TRANSFERASE-RXN is_obsolete: true replaced_by: GO:0034227 consider: GO:0016783 @@ -123981,6 +124175,7 @@ synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosa synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT [] xref: EC:2.4.1.94 xref: MetaCyc:2.4.1.94-RXN +xref: RHEA:16533 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -123997,6 +124192,7 @@ xref: EC:2.4.1.122 xref: MetaCyc:2.4.1.122-RXN xref: Reactome:R-HSA-1964505 "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)" xref: Reactome:R-HSA-6785524 "Defective C1GALT1C1 does not bind C1GALT1" +xref: RHEA:15621 is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein @@ -124112,6 +124308,7 @@ synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferase synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124] xref: EC:2.1.1.124 xref: MetaCyc:2.1.1.124-RXN +xref: RHEA:21872 is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] @@ -124145,7 +124342,6 @@ name: protein-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878] xref: Reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27" -xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3" xref: Reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex" xref: Reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB" xref: Reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A" @@ -124277,6 +124473,7 @@ synonym: "tetradecanoyl-ACP hydrolase activity" EXACT [] xref: EC:3.1.2.14 xref: KEGG_REACTION:R08159 xref: MetaCyc:RXN-10727 +xref: RHEA:30123 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] @@ -124289,6 +124486,7 @@ synonym: "palmitoyl-ACP hydrolase activity" EXACT [] xref: EC:3.1.2.14 xref: KEGG_REACTION:R08162 xref: MetaCyc:RXN-9549 +xref: RHEA:41932 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] @@ -124307,6 +124505,7 @@ synonym: "S-acyl fatty acid synthase thioesterase activity" EXACT [EC:3.1.2.14] xref: EC:3.1.2.14 xref: MetaCyc:RXN-7902 xref: Reactome:R-HSA-5655955 "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer" +xref: RHEA:30131 is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016790 ! thiolester hydrolase activity @@ -124512,6 +124711,7 @@ namespace: molecular_function def: "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate." [GOC:hb] xref: Reactome:R-HSA-6809561 "I(1,3)P2 is dephosphorylated into I1P by MTMR7" xref: Reactome:R-HSA-6809565 "I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9" +xref: RHEA:57840 is_a: GO:0052745 ! inositol phosphate phosphatase activity [Term] @@ -124968,6 +125168,7 @@ def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristano xref: EC:1.3.3 xref: Reactome:R-HSA-389889 "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA" xref: Reactome:R-HSA-389891 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)" +xref: RHEA:40459 is_a: GO:0003997 ! acyl-CoA oxidase activity [Term] @@ -124982,6 +125183,7 @@ synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5. xref: EC:3.5.3.18 xref: MetaCyc:DIMETHYLARGININASE-RXN xref: Reactome:R-HSA-5693373 "DDAH1,2 hydrolyses ADMA to DMA and L-Cit" +xref: RHEA:17305 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] @@ -125014,7 +125216,7 @@ def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + s xref: Reactome:R-HSA-159443 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate" xref: Reactome:R-HSA-159567 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate" xref: Reactome:R-HSA-177157 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate" -xref: Reactome:R-HSA-6798345 "GCAT:PXLP dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA" +xref: Reactome:R-HSA-6798345 "PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA" is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] @@ -125163,6 +125365,7 @@ synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransfe synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.62] xref: EC:2.1.1.62 xref: MetaCyc:2.1.1.62-RXN +xref: RHEA:22744 is_a: GO:0008174 ! mRNA methyltransferase activity [Term] @@ -125231,6 +125434,7 @@ synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.55] xref: EC:2.1.1.55 xref: MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN +xref: RHEA:16785 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity @@ -125242,6 +125446,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-met synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.25] xref: EC:2.5.1.25 xref: MetaCyc:2.5.1.25-RXN +xref: RHEA:12300 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -125311,6 +125516,7 @@ def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA( synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.110] xref: EC:2.4.1.110 xref: MetaCyc:2.4.1.110-RXN +xref: RHEA:12885 is_a: GO:0000030 ! mannosyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -125325,6 +125531,7 @@ synonym: "PTGS" EXACT [] synonym: "quelling" EXACT [] xref: Wikipedia:Post_transcriptional_gene_silencing is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0016458 ! gene silencing is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] @@ -125466,6 +125673,7 @@ name: pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators] xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP" +xref: RHEA:51724 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] @@ -125713,7 +125921,6 @@ def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol synonym: "farnesol metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016093 ! polyprenol metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0034308 ! primary alcohol metabolic process [Term] @@ -125727,7 +125934,6 @@ synonym: "farnesol degradation" EXACT [] is_a: GO:0016095 ! polyprenol catabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0016487 ! farnesol metabolic process -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0034310 ! primary alcohol catabolic process [Term] @@ -125772,6 +125978,7 @@ xref: Reactome:R-HSA-9025007 "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA xref: Reactome:R-HSA-9026001 "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA" xref: Reactome:R-HSA-9026917 "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA" xref: Reactome:R-HSA-9027033 "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA" +xref: RHEA:27453 is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0055114 ! oxidation-reduction process @@ -125950,6 +126157,7 @@ synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" EXACT [ xref: EC:1.1.1.211 xref: MetaCyc:1.1.1.211-RXN xref: Reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA" +xref: RHEA:52656 is_a: GO:0003857 ! 3-hydroxyacyl-CoA dehydrogenase activity [Term] @@ -125970,8 +126178,6 @@ def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Tr comment: This term was made obsolete because it represents a gene product. synonym: "ECE-1 activity" EXACT [EC:3.4.24.71] synonym: "endothelin-converting enzyme 1 activity" EXACT [] -xref: EC:3.4.24.71 -xref: MetaCyc:3.4.24.71-RXN is_obsolete: true replaced_by: GO:0004222 @@ -126119,6 +126325,7 @@ namespace: molecular_function def: "Directly binding to and delivering metal ions to a target protein." [PMID:11739376] subset: goslim_pir is_a: GO:0140104 ! molecular carrier activity +relationship: has_part GO:0046872 ! metal ion binding [Term] id: GO:0016531 @@ -126682,9 +126889,7 @@ def: "Interacting selectively and non-covalently with glycine, aminoethanoic aci synonym: "aminoacetic acid binding" EXACT [] synonym: "aminoethanoic acid binding" EXACT [] synonym: "Gly binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0016597 ! amino acid binding -is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043169 ! cation binding [Term] @@ -126702,6 +126907,7 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with thienylcyclohexylpiperidine." [GOC:jl] synonym: "TCP binding" BROAD [] is_a: GO:0008144 ! drug binding +is_a: GO:0043169 ! cation binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding @@ -126763,6 +126969,7 @@ synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5] synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.5] xref: EC:2.3.2.5 xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN +xref: RHEA:23652 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] @@ -126898,6 +127105,7 @@ synonym: "NADH:hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] xref: EC:1.1.1.81 xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN xref: MetaCyc:RXN0-300 +xref: RHEA:18657 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -126979,6 +127187,7 @@ def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH grou synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW [] xref: EC:1.3 xref: Reactome:R-HSA-2995334 "COX15 transforms heme O to heme A" +xref: Reactome:R-HSA-9661710 "An unknown oxidase oxidises D-UBGN to UBN" is_a: GO:0016491 ! oxidoreductase activity [Term] @@ -126989,6 +127198,8 @@ def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH grou xref: EC:1.3.1 xref: Reactome:R-HSA-4419979 "SRD5A3 reduces pPNOL to DCHOL" xref: Reactome:R-HSA-4755572 "Defective SRD5A3 does not reduce pPNOL to DCHOL" +xref: Reactome:R-HSA-9661726 "An unknown reductase reduces D-UBGN to STBN" +xref: Reactome:R-HSA-9661745 "An unknown BILR reduces BIL to D-UBGN" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] @@ -127068,6 +127279,7 @@ synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" E synonym: "L-galactonolactone dehydrogenase activity" EXACT [EC:1.3.2.3] xref: EC:1.3.2.3 xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN +xref: RHEA:32367 is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor [Term] @@ -127542,6 +127754,7 @@ synonym: "L-ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbic acid-specific peroxidase activity" EXACT [EC:1.11.1.11] xref: EC:1.11.1.11 xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN +xref: RHEA:22996 is_a: GO:0004601 ! peroxidase activity [Term] @@ -127807,7 +128020,7 @@ id: GO:0016711 name: flavonoid 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.14.82] -synonym: "flavonoid 3'-hydroxylase activity" EXACT [b] +synonym: "flavonoid 3'-hydroxylase activity" EXACT [EC:1.14.14.82] synonym: "flavonoid 3-hydroxylase" RELATED [] synonym: "flavonoid 3-monooxygenase" RELATED [] synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.14.82] @@ -128107,7 +128320,6 @@ xref: EC:2 xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" -xref: Reactome:R-HSA-6787403 "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA" xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity @@ -128255,6 +128467,7 @@ synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltrans synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15] xref: EC:2.3.2.15 xref: MetaCyc:2.3.2.15-RXN +xref: RHEA:17917 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] @@ -128317,6 +128530,7 @@ synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] xref: EC:2.4.1.12 xref: MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN +xref: RHEA:19929 is_a: GO:0016759 ! cellulose synthase activity is_a: GO:0035251 ! UDP-glucosyltransferase activity @@ -128334,6 +128548,7 @@ synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activit synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] xref: EC:2.4.1.29 xref: MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN +xref: RHEA:17797 is_a: GO:0016759 ! cellulose synthase activity [Term] @@ -128632,7 +128847,7 @@ name: phosphatase activity namespace: molecular_function alt_id: GO:0003869 alt_id: GO:0016302 -def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators, GOC:pg] +def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:curators, GOC:pg] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl @@ -128641,21 +128856,21 @@ subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "4-nitrophenylphosphatase activity" NARROW [] -synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] -synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] -synonym: "K-pNPPase activity" NARROW [EC:3.1.3.41] -synonym: "nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] -synonym: "NPPase activity" NARROW [EC:3.1.3.41] -synonym: "p-nitrophenylphosphatase activity" NARROW [EC:3.1.3.41] -synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] -synonym: "para-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] +synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [] +synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [] +synonym: "K-pNPPase activity" NARROW [] +synonym: "nitrophenyl phosphatase activity" NARROW [] +synonym: "NPPase activity" NARROW [] +synonym: "p-nitrophenylphosphatase activity" NARROW [] +synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [] +synonym: "para-nitrophenyl phosphatase activity" NARROW [] synonym: "phosphatase" RELATED [] synonym: "phosphoric monoester hydrolase activity" EXACT [] -synonym: "PNPPase activity" NARROW [EC:3.1.3.41] +synonym: "PNPPase activity" NARROW [] xref: EC:3.1.3 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN xref: Reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL" -xref: RHEA:21664 +xref: Reactome:R-HSA-9636457 "SapM dephosphorylates PI3P" is_a: GO:0042578 ! phosphoric ester hydrolase activity relationship: part_of GO:0016311 ! dephosphorylation @@ -128666,6 +128881,7 @@ namespace: molecular_function def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai] xref: EC:3.1.5 xref: Reactome:R-HSA-8866601 "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate" +xref: RHEA:46148 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] @@ -128766,8 +128982,6 @@ synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5] synonym: "proline iminopeptidase activity" EXACT [] synonym: "prolyl aminopeptidase activity" EXACT [] -xref: EC:3.4.11.5 -xref: MetaCyc:3.4.11.5-RXN is_obsolete: true replaced_by: GO:0004177 @@ -128777,10 +128991,14 @@ name: dipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a dipeptide." [PMID:19879002] xref: EC:3.4.13 +xref: EC:3.4.13.18 +xref: EC:3.4.13.21 +xref: MetaCyc:3.4.13.18-RXN +xref: MetaCyc:3.4.13.21-RXN xref: Reactome:R-HSA-266012 "LTD4 is converted to LTE4 by DPEP1/2" xref: Reactome:R-HSA-5433067 "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG" xref: Reactome:R-HSA-5693783 "NAALADases hydrolyse NAAG" -xref: Reactome:R-HSA-9026771 "DPEP hydroyses MCTR2 to MCTR3" +xref: Reactome:R-HSA-9026771 "DPEP hydrolyses MCTR2 to MCTR3" is_a: GO:0008238 ! exopeptidase activity [Term] @@ -128810,7 +129028,6 @@ namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "proprotein convertase activity" EXACT [] -xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 @@ -128825,6 +129042,7 @@ subset: goslim_generic synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] xref: EC:3.5 xref: Reactome:R-HSA-6803753 "NAAA hydrolyses NAEs to FAs and ethanolamine" +xref: RHEA:45456 is_a: GO:0016787 ! hydrolase activity [Term] @@ -128833,6 +129051,8 @@ name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] xref: EC:3.5.1 +xref: Reactome:R-HSA-9673053 "PM20D1 transforms oleoyl-phe from oleate and phe" +xref: Reactome:R-HSA-9673054 "PM20D1 hydrolyzes oleoyl-phe" is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] @@ -128987,8 +129207,9 @@ subset: goslim_pir subset: goslim_yeast synonym: "other lyase activity" NARROW [] xref: EC:4 -xref: Reactome:R-HSA-5696408 "PHYKPL tetramer hydrolyses 5PHL" +xref: Reactome:R-HSA-5696408 "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL" xref: Reactome:R-HSA-6782895 "TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)" +xref: RHEA:34091 is_a: GO:0003824 ! catalytic activity [Term] @@ -128999,17 +129220,18 @@ def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis o synonym: "other carbon-carbon lyase activity" NARROW [] xref: EC:4.1 xref: Reactome:R-HSA-389611 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA" +xref: RHEA:25355 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016831 name: carboxy-lyase activity namespace: molecular_function -def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/] +def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators] synonym: "decarboxylase activity" EXACT [] xref: EC:4.1.1 -xref: Reactome:R-HSA-6787757 "GADL1 decarboxylates acidic AAs" -xref: Reactome:R-HSA-6814165 "GADL1 decarboxylates CSA to HTAU" +xref: Reactome:R-HSA-6787757 "PXLP-K333-GADL1 decarboxylates acidic AAs" +xref: Reactome:R-HSA-6814165 "PXLP-K333-GADL1 decarboxylates CSA to HTAU" xref: Reactome:R-HSA-71223 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2" is_a: GO:0016830 ! carbon-carbon lyase activity @@ -129018,7 +129240,7 @@ id: GO:0016832 name: aldehyde-lyase activity namespace: molecular_function alt_id: GO:0016228 -def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/] +def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators] synonym: "aldolase activity" BROAD [] xref: EC:4.1.2 is_a: GO:0016830 ! carbon-carbon lyase activity @@ -129322,6 +129544,7 @@ synonym: "intramolecular isomerase activity" EXACT [] synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW [] xref: EC:5.3 xref: Reactome:R-HSA-109998 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" +xref: RHEA:45752 is_a: GO:0016853 ! isomerase activity [Term] @@ -129439,7 +129662,7 @@ is_a: GO:0031559 ! oxidosqualene cyclase activity id: GO:0016872 name: intramolecular lyase activity namespace: molecular_function -def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/] +def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl] xref: EC:5.5.1 is_a: GO:0016853 ! isomerase activity @@ -129457,7 +129680,7 @@ consider: GO:0016853 id: GO:0016874 name: ligase activity namespace: molecular_function -def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] +def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl @@ -129470,6 +129693,7 @@ subset: goslim_yeast synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6 is_a: GO:0003824 ! catalytic activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19380 xsd:anyURI [Term] id: GO:0016875 @@ -129616,6 +129840,7 @@ xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG" xref: Reactome:R-HSA-917693 "ESCRT Disassembly" xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP" +xref: Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope" xref: RHEA:13065 is_a: GO:0017111 ! nucleoside-triphosphatase activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19078 xsd:anyURI @@ -129793,6 +130018,7 @@ synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin-heavy-chain kinase activity" EXACT [EC:2.7.11.7] synonym: "STK6" RELATED [EC:2.7.11.7] xref: EC:2.7.11.7 +xref: RHEA:11424 is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] @@ -129953,8 +130179,6 @@ synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61] synonym: "nardilysin activity" EXACT [] synonym: "NRD convertase activity" EXACT [EC:3.4.24.61] synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61] -xref: EC:3.4.24.61 -xref: MetaCyc:3.4.24.61-RXN is_obsolete: true replaced_by: GO:0004222 @@ -129964,6 +130188,7 @@ name: pyroglutamyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah] xref: EC:3.4.19 +is_a: GO:0008234 ! cysteine-type peptidase activity is_a: GO:0008242 ! omega peptidase activity [Term] @@ -130169,8 +130394,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin F activity" EXACT [] -xref: EC:3.4.22.41 -xref: MetaCyc:3.4.22.41-RXN is_obsolete: true replaced_by: GO:0004197 @@ -130221,6 +130444,7 @@ synonym: "P450nor" NARROW [] xref: EC:1.7.2.5 xref: KEGG_REACTION:R00294 xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN +xref: RHEA:30211 is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] @@ -130457,6 +130681,7 @@ synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [ xref: EC:2.8.1.8 xref: MetaCyc:RXN0-949 xref: Reactome:R-HSA-6793591 "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH" +xref: RHEA:16585 is_a: GO:0016783 ! sulfurtransferase activity relationship: part_of GO:0009107 ! lipoate biosynthetic process @@ -130792,8 +131017,6 @@ synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19] -xref: EC:3.4.24.19 -xref: MetaCyc:3.4.24.19-RXN is_obsolete: true replaced_by: GO:0004222 @@ -130875,8 +131098,6 @@ synonym: "dipeptidyl-peptidase III activity" EXACT [] synonym: "DPP III activity" EXACT [EC:3.4.14.4] synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4] synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4] -xref: EC:3.4.14.4 -xref: MetaCyc:3.4.14.4-RXN is_obsolete: true replaced_by: GO:0008239 @@ -130910,6 +131131,7 @@ synonym: "trihexosyl ceramide galactosidase activity" EXACT [EC:3.2.1.47] synonym: "trihexosylceramide alpha-galactosidase activity" EXACT [EC:3.2.1.47] xref: EC:3.2.1.47 xref: MetaCyc:3.2.1.47-RXN +xref: RHEA:21112 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -130997,6 +131219,7 @@ xref: MetaCyc:RXN3DJ-11417 xref: Reactome:R-HSA-428273 "sphingosine +ATP => sphingosine 1-phosphate + ADP" xref: Reactome:R-HSA-5218845 "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate" xref: Reactome:R-HSA-9625814 "SPHK1 phosphorylates sphingosine in response to E2 stimulation" +xref: RHEA:35847 is_a: GO:0016301 ! kinase activity [Term] @@ -131170,6 +131393,7 @@ synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-tra xref: EC:2.4.2.28 xref: MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN xref: Reactome:R-HSA-1237160 "MTA is cleaved and phosphorylated" +xref: RHEA:11852 is_a: GO:0004731 ! purine-nucleoside phosphorylase activity [Term] @@ -131282,8 +131506,6 @@ synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14] synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14] synonym: "type III procollagen" RELATED [EC:3.4.24.14] -xref: EC:3.4.24.14 -xref: MetaCyc:3.4.24.14-RXN is_obsolete: true replaced_by: GO:0004222 @@ -131379,6 +131601,7 @@ namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI] synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT [] xref: Reactome:R-HSA-508040 "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]" +xref: RHEA:33207 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -131404,7 +131627,7 @@ is_a: GO:0032991 ! protein-containing complex id: GO:0017087 name: mitochondrial processing peptidase complex namespace: cellular_component -def: "A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [BRENDA:3.4.24.64, EC:3.4.24.64, GOC:mah] +def: "A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [GOC:mah] comment: Note that monomeric mitochondrial processing peptidases have been observed. is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix @@ -131420,8 +131643,6 @@ synonym: "X-Pro dipeptidyl-peptidase activity" EXACT [] synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11] synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11] synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT [] -xref: EC:3.4.14.11 -xref: MetaCyc:3.4.14.11-RXN is_obsolete: true replaced_by: GO:0008239 @@ -131478,7 +131699,7 @@ comment: This term was made obsolete because it represents a gene product. synonym: "SREBP protease activity" EXACT [] synonym: "sterol regulatory element-binding protein protease activity" EXACT [] is_obsolete: true -replaced_by: GO:0070011 +replaced_by: GO:0008233 [Term] id: GO:0017094 @@ -131536,6 +131757,7 @@ def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + red synonym: "very long-chain-acyl-CoA dehydrogenase activity" EXACT [] xref: EC:1.3.99 xref: Reactome:R-HSA-548831 "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA" +xref: RHEA:35351 is_a: GO:0004466 ! long-chain-acyl-CoA dehydrogenase activity [Term] @@ -131614,6 +131836,7 @@ namespace: molecular_function def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254] synonym: "5' flap endonuclease activity" EXACT [] xref: Reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA" +xref: Reactome:R-HSA-174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand" xref: Reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)" xref: Reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ" @@ -131656,6 +131879,7 @@ xref: Reactome:R-HSA-8851225 "NTPDase4 hydrolyzes nucleoside diphosphates" xref: Reactome:R-HSA-8851356 "NTPDase5 hydrolyzes nucleoside diphosphates" xref: Reactome:R-HSA-8851396 "NTPDase6 hydrolyzes nucleoside diphosphates" xref: Reactome:R-HSA-8851550 "NTPDase8 hydrolyzes nucleoside diphosphates" +xref: RHEA:36799 is_a: GO:0016462 ! pyrophosphatase activity [Term] @@ -131777,7 +132001,7 @@ is_a: GO:0016747 ! transferase activity, transferring acyl groups other than ami id: GO:0017119 name: Golgi transport complex namespace: cellular_component -def: "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). In mammals the subunits are named COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665] +def: "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665] synonym: "COG complex" EXACT [] synonym: "conserved oligomeric Golgi complex" EXACT [] synonym: "Sec34/35 complex" NARROW [] @@ -131851,7 +132075,7 @@ id: GO:0017128 name: phospholipid scramblase activity namespace: molecular_function def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864] -comment: Nomenclature note. Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Some authors however use the name floppase to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). +comment: Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0140303 ! intramembrane lipid transporter activity relationship: part_of GO:0017121 ! plasma membrane phospholipid scrambling @@ -132082,6 +132306,7 @@ namespace: molecular_function def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710] xref: MetaCyc:RXN0-1281 xref: Reactome:R-HSA-6782296 "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs" +xref: RHEA:23624 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0002943 ! tRNA dihydrouridine synthesis @@ -132182,8 +132407,8 @@ id: GO:0017161 name: inositol-1,3,4-trisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai] -xref: EC:3.1.3 xref: Reactome:R-HSA-1855180 "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol" +xref: RHEA:43392 is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] @@ -132228,8 +132453,6 @@ synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21] synonym: "dipeptidase E activity" EXACT [] synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21] synonym: "peptidase E activity" BROAD [EC:3.4.13.21] -xref: EC:3.4.13.21 -xref: MetaCyc:3.4.13.21-RXN is_obsolete: true replaced_by: GO:0016805 @@ -132808,6 +133031,7 @@ xref: Reactome:R-HSA-5651657 "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methy xref: RESID:AA0074 xref: RESID:AA0075 xref: RESID:AA0076 +xref: RHEA:10024 is_a: GO:0016279 ! protein-lysine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity relationship: part_of GO:0034968 ! histone lysine methylation @@ -132823,6 +133047,7 @@ synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" xref: EC:2.1.1.60 xref: MetaCyc:2.1.1.60-RXN xref: Reactome:R-HSA-6786205 "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1" +xref: RHEA:21556 is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] @@ -133159,15 +133384,17 @@ synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" EXACT [EC:2.1.1.85] xref: EC:2.1.1.85 xref: MetaCyc:2.1.1.85-RXN +xref: RHEA:19369 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018065 -name: protein-cofactor linkage +name: obsolete protein-cofactor linkage namespace: biological_process -def: "The covalent attachment of a cofactor to a protein." [GOC:ai] -is_a: GO:0006464 ! cellular protein modification process +def: "OBSOLETE. The covalent attachment of a cofactor to a protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group protein modification processes that are not all chemically related by the fact that they may be used as a cofactor. +is_obsolete: true [Term] id: GO:0018067 @@ -133990,7 +134217,6 @@ def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via synonym: "dipyrromethane cofactor binding" RELATED [GOC:jsg] synonym: "peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine" EXACT [GOC:jsg] xref: RESID:AA0252 -is_a: GO:0018065 ! protein-cofactor linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] @@ -134280,7 +134506,6 @@ synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT [] xref: RESID:AA0283 is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0018212 ! peptidyl-tyrosine modification -is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process @@ -134743,7 +134968,7 @@ id: GO:0018246 name: protein-coenzyme A linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah] -is_a: GO:0018065 ! protein-cofactor linkage +is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018247 @@ -135223,7 +135448,7 @@ id: GO:0018293 name: protein-FAD linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai] -is_a: GO:0018065 ! protein-cofactor linkage +is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018294 @@ -135380,7 +135605,7 @@ id: GO:0018309 name: protein-FMN linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah] -is_a: GO:0018065 ! protein-cofactor linkage +is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018310 @@ -135726,7 +135951,7 @@ id: GO:0018352 name: protein-pyridoxal-5-phosphate linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate." [GOC:mah] -is_a: GO:0018065 ! protein-cofactor linkage +is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018353 @@ -135845,6 +136070,7 @@ def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5 synonym: "protein-serine racemase activity" EXACT [EC:5.1.1.16] xref: EC:5.1.1.16 xref: MetaCyc:5.1.1.16-RXN +xref: RHEA:10660 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] @@ -136428,6 +136654,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_reactionID:r0427] xref: EC:1.1.1.327 xref: MetaCyc:R542-RXN +xref: RHEA:32879 xref: UM-BBD_reactionID:r0427 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -136483,6 +136710,7 @@ synonym: "benzyl alcohol dehydrogenase activity" NARROW [] synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90] xref: EC:1.1.1.90 xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN +xref: RHEA:12076 xref: UM-BBD_enzymeID:e0019 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -136727,6 +136955,7 @@ synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylati synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT [] xref: EC:1.2.1.18 xref: MetaCyc:1.2.1.18-RXN +xref: RHEA:22988 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -136845,6 +137074,7 @@ def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic a synonym: "aryl-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.9] xref: EC:1.2.3.9 xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN +xref: RHEA:18569 xref: UM-BBD_reactionID:r0145 is_a: GO:0004031 ! aldehyde oxidase activity @@ -136891,6 +137121,7 @@ synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT [] synonym: "alpha-ketobutyrate synthase activity" EXACT [] synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT [] xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN +xref: RHEA:32135 xref: UM-BBD_reactionID:r0358 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor @@ -136964,6 +137195,7 @@ name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308] xref: MetaCyc:PHENPRODIOLDEHYDROG-RXN +xref: RHEA:25062 xref: UM-BBD_enzymeID:e0308 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor @@ -136997,6 +137229,7 @@ name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_reactionID:r0553] xref: MetaCyc:LINC-RXN +xref: RHEA:15741 xref: UM-BBD_reactionID:r0553 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor @@ -137018,6 +137251,7 @@ synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) synonym: "cis-benzene glycol dehydrogenase activity" EXACT [EC:1.3.1.19] xref: EC:1.3.1.19 xref: MetaCyc:1.3.1.19-RXN +xref: RHEA:15457 xref: UM-BBD_enzymeID:e0060 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor @@ -137239,6 +137473,7 @@ synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatiz xref: EC:1.3.7.8 xref: KEGG_REACTION:R02451 xref: MetaCyc:1.3.99.15-RXN +xref: RHEA:30199 xref: UM-BBD_reactionID:r0190 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor @@ -137250,6 +137485,7 @@ def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)- synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.17] xref: EC:1.3.99.17 xref: MetaCyc:1.3.99.17-RXN +xref: RHEA:17749 xref: UM-BBD_reactionID:r0045 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors @@ -137273,6 +137509,7 @@ synonym: "4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity" EXACT [EC:1.3 xref: EC:1.3.7.9 xref: KEGG_REACTION:R05316 xref: MetaCyc:OHBENZCOARED-RXN +xref: RHEA:29603 xref: UM-BBD_reactionID:r0158 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor @@ -137473,6 +137710,7 @@ name: nitrobenzene nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O." [MetaCyc:RXN-8815] xref: MetaCyc:RXN-8815 +xref: RHEA:52884 xref: UM-BBD_enzymeID:e0245 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor @@ -137706,6 +137944,7 @@ namespace: molecular_function def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_reactionID:r0395] xref: EC:1.13.11 xref: MetaCyc:RXN-664 +xref: RHEA:42344 xref: UM-BBD_reactionID:r0395 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen @@ -137718,6 +137957,7 @@ synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT [] synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT [] xref: EC:1.13.11 xref: MetaCyc:RXN-666 +xref: RHEA:42568 xref: UM-BBD_reactionID:r0397 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen @@ -138059,6 +138299,7 @@ name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2." [UM-BBD_reactionID:r0274] xref: MetaCyc:RXN-9863 +xref: RHEA:48984 xref: UM-BBD_reactionID:r0274 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity @@ -138124,6 +138365,7 @@ namespace: molecular_function def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN] xref: EC:1.14.12 xref: MetaCyc:R606-RXN +xref: RHEA:42460 xref: UM-BBD_enzymeID:e0030 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor @@ -138403,6 +138645,7 @@ namespace: molecular_function def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone." [UM-BBD_reactionID:r0226] xref: EC:1.14.13 xref: MetaCyc:RXN-8739 +xref: RHEA:34327 xref: UM-BBD_reactionID:r0226 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -138485,6 +138728,7 @@ namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621] xref: EC:1.14.13 xref: MetaCyc:RXN-621 +xref: RHEA:49076 xref: UM-BBD_enzymeID:e0214 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -138523,6 +138767,7 @@ namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [UM-BBD_enzymeID:e0222] xref: EC:1.14.13 xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN +xref: RHEA:20349 xref: UM-BBD_enzymeID:e0222 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -138610,6 +138855,7 @@ def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT [] xref: EC:1.14.13 xref: MetaCyc:TSMOS-RXN +xref: RHEA:51024 xref: UM-BBD_reactionID:r0290 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -138873,6 +139119,7 @@ synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXA synonym: "4-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.33] xref: EC:1.14.13.33 xref: MetaCyc:1.14.13.33-RXN +xref: RHEA:19473 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -138967,6 +139214,7 @@ synonym: "pentachlorophenol hydroxylase activity" EXACT [] synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" EXACT [EC:1.14.13.50] xref: EC:1.14.13.50 xref: MetaCyc:PCP4MONO-RXN +xref: RHEA:18685 xref: UM-BBD_enzymeID:e0148 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -139042,6 +139290,7 @@ synonym: "methylene hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "methylene monooxygenase activity" EXACT [EC:1.14.15.1] xref: EC:1.14.15.1 xref: MetaCyc:R541-RXN +xref: RHEA:13525 xref: UM-BBD_enzymeID:e0300 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen @@ -139077,6 +139326,7 @@ synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3] xref: EC:1.14.15.3 xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN +xref: RHEA:19341 xref: UM-BBD_enzymeID:e0022 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen @@ -139162,6 +139412,7 @@ namespace: molecular_function def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_reactionID:r0392] xref: EC:1.17.99 xref: MetaCyc:RXN-661 +xref: RHEA:51604 xref: UM-BBD_reactionID:r0392 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups @@ -139278,6 +139529,7 @@ synonym: "pyrogallol hydroxyltransferase activity" EXACT [] synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2] xref: EC:1.97.1.2 xref: MetaCyc:1.97.1.2-RXN +xref: RHEA:21000 xref: UM-BBD_reactionID:r0006 is_a: GO:0016491 ! oxidoreductase activity @@ -139300,6 +139552,7 @@ synonym: "TMT" RELATED [EC:2.1.1.9] xref: EC:2.1.1.9 xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN xref: Reactome:R-HSA-175976 "TMT transfers CH3 from AdoMet to BME" +xref: RHEA:18277 xref: UM-BBD_enzymeID:e0146 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity @@ -139729,6 +139982,7 @@ name: ammeline aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731] xref: MetaCyc:RXN-8016 +xref: RHEA:26201 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] @@ -139800,6 +140054,7 @@ def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7] synonym: "aliphatic nitrile aminohydrolase activity" EXACT [EC:3.5.5.7] xref: EC:3.5.5.7 xref: MetaCyc:3.5.5.7-RXN +xref: RHEA:46188 xref: UM-BBD_reactionID:r0622 is_a: GO:0000257 ! nitrilase activity @@ -139836,6 +140091,7 @@ name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_reactionID:r0263] xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN +xref: RHEA:59220 xref: UM-BBD_reactionID:r0263 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances @@ -140029,6 +140285,7 @@ synonym: "L-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "L-DEX activity" EXACT [EC:3.8.1.2] xref: EC:3.8.1.2 xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN +xref: RHEA:11192 xref: UM-BBD_reactionID:r0090 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds @@ -140041,6 +140298,7 @@ synonym: "haloacetate halidohydrolase activity" EXACT [EC:3.8.1.3] synonym: "monohaloacetate dehalogenase activity" EXACT [EC:3.8.1.3] xref: EC:3.8.1.3 xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN +xref: RHEA:11044 xref: UM-BBD_enzymeID:e0006 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds @@ -140361,6 +140619,7 @@ synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT [] synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT [] synonym: "HpaH" RELATED [] xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN +xref: RHEA:42072 xref: UM-BBD_reactionID:r0369 is_a: GO:0016836 ! hydro-lyase activity @@ -140458,6 +140717,7 @@ synonym: "HAB mutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene hydroxymutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene mutase activity" EXACT [EC:5.4.4.1] xref: MetaCyc:5.4.4.1-RXN +xref: RHEA:19245 xref: UM-BBD_reactionID:r0304 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups @@ -140593,6 +140853,7 @@ synonym: "organomercurial lyase activity" EXACT [EC:4.99.1.2] synonym: "organomercury lyase activity" EXACT [EC:4.99.1.2] xref: EC:4.99.1.2 xref: MetaCyc:ALKYLMERCURY-LYASE-RXN +xref: RHEA:18777 xref: UM-BBD_enzymeID:e0055 is_a: GO:0016829 ! lyase activity @@ -140772,6 +141033,7 @@ name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_reactionID:r0429] xref: EC:6.2.1.38 +xref: RHEA:33419 xref: UM-BBD_reactionID:r0429 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity @@ -140800,7 +141062,7 @@ is_a: GO:0016878 ! acid-thiol ligase activity id: GO:0018858 name: benzoate-CoA ligase activity namespace: molecular_function -def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate + H(+)." [EC:6.2.1.25, RHEA:10132] +def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate." [EC:6.2.1.25, RHEA:10132] synonym: "benzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.25] synonym: "benzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.25] synonym: "benzoyl CoA synthetase (AMP forming)" EXACT [EC:6.2.1.25] @@ -140903,7 +141165,6 @@ def: "The chemical reactions and pathways involving acrylonitrile, a colorless, synonym: "acrylonitrile metabolism" EXACT [] xref: UM-BBD_pathwayID:acr is_a: GO:0006805 ! xenobiotic metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0050898 ! nitrile metabolic process @@ -140991,7 +141252,6 @@ def: "The chemical reactions and pathways involving benzoate, the anion of benzo synonym: "benzoate metabolism" EXACT [] xref: MetaCyc:P321-PWY xref: UM-BBD_pathwayID:benz2 -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -141042,7 +141302,6 @@ synonym: "biphenyl metabolism" EXACT [] synonym: "xenene metabolic process" EXACT [] synonym: "xenene metabolism" EXACT [] xref: UM-BBD_pathwayID:bph -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] @@ -141062,7 +141321,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai] synonym: "bromoxynil metabolism" EXACT [] xref: UM-BBD_pathwayID:box -is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0050898 ! nitrile metabolic process @@ -141155,7 +141413,6 @@ synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT [] synonym: "propachlor metabolic process" EXACT [] synonym: "propachlor metabolism" EXACT [] xref: UM-BBD_pathwayID:ppc -is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process @@ -141201,7 +141458,6 @@ def: "The chemical reactions and pathways involving dibenzofuran, a substance co synonym: "dibenzofuran metabolism" EXACT [] xref: UM-BBD_pathwayID:dbf is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -141218,7 +141474,6 @@ synonym: "phenodioxin metabolic process" EXACT [] synonym: "phenodioxin metabolism" EXACT [] xref: UM-BBD_pathwayID:dpd is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -141232,7 +141487,6 @@ synonym: "dibenzothiophene metabolism" EXACT [] synonym: "diphenylene sulfide metabolic process" EXACT [] synonym: "diphenylene sulfide metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -141247,7 +141501,6 @@ synonym: "dibenzothiophene degradation" EXACT [] xref: UM-BBD_pathwayID:dbt2 is_a: GO:0018895 ! dibenzothiophene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -141299,8 +141552,6 @@ synonym: "2,4-D metabolic process" EXACT [] synonym: "2,4-D metabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:2\,4-d -is_a: GO:0006805 ! xenobiotic metabolic process -is_a: GO:0009850 ! auxin metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -141377,7 +141628,6 @@ synonym: "DMSO metabolic process" EXACT [] synonym: "DMSO metabolism" EXACT [] xref: UM-BBD_pathwayID:sulf is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] @@ -141426,7 +141676,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm] synonym: "1,4-dichlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:dcz -is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] @@ -141474,7 +141723,6 @@ def: "The chemical reactions and pathways involving fluorene, a tricyclic polycy synonym: "fluorene metabolism" EXACT [] xref: UM-BBD_pathwayID:flu is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] @@ -141486,7 +141734,6 @@ synonym: "gallate metabolism" EXACT [] synonym: "gallic acid metabolic process" EXACT [] synonym: "gallic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:gal -is_a: GO:0017144 ! drug metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -141499,8 +141746,6 @@ def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachloro synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] xref: MetaCyc:GAMMAHEXCHLORDEG-PWY xref: UM-BBD_pathwayID:ghch -is_a: GO:0016999 ! antibiotic metabolic process -is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0019497 ! hexachlorocyclohexane metabolic process [Term] @@ -141514,7 +141759,6 @@ synonym: "Roundup metabolism" EXACT [] xref: UM-BBD_pathwayID:gly is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006793 ! phosphorus metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] @@ -141534,7 +141778,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [UM-BBD_pathwayID:ipd] synonym: "iprodione metabolism" EXACT [] xref: UM-BBD_pathwayID:ipd -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process @@ -141559,7 +141802,6 @@ synonym: "mandelate metabolism" EXACT [] synonym: "mandelic acid metabolic process" EXACT [] synonym: "mandelic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:mca -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process @@ -141632,7 +141874,6 @@ def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, a synonym: "3-methylquinoline metabolism" EXACT [] xref: UM-BBD_pathwayID:mqn is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process @@ -141644,7 +141885,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide." [http://www.iversonsoftware.com/reference/chemistry/n/Naphthalene.htm] synonym: "naphthalene metabolism" EXACT [] xref: UM-BBD_pathwayID:naph -is_a: GO:0017144 ! drug metabolic process is_a: GO:0090420 ! naphthalene-containing compound metabolic process [Term] @@ -141653,7 +141893,7 @@ name: nicotine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] synonym: "nicotine metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process +is_a: GO:0008152 ! metabolic process [Term] id: GO:0018934 @@ -141694,7 +141934,6 @@ xref: MetaCyc:P201-PWY xref: UM-BBD_pathwayID:ng is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] @@ -141854,7 +142093,6 @@ xref: UM-BBD_pathwayID:pthn is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process -is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] @@ -141876,7 +142114,6 @@ synonym: "pentaerythritol tetranitrate metabolism" EXACT [] xref: UM-BBD_pathwayID:petn is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] @@ -141887,8 +142124,6 @@ def: "The chemical reactions and pathways involving phenanthrene, a tricyclic ar synonym: "phenanthrene metabolism" EXACT [] xref: UM-BBD_pathwayID:pha is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0006805 ! xenobiotic metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] @@ -141957,7 +142192,6 @@ synonym: "PCP metabolic process" EXACT [] synonym: "PCP metabolism" EXACT [] synonym: "pentachlorophenol metabolism" EXACT [] xref: UM-BBD_pathwayID:pcp -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -141972,7 +142206,6 @@ synonym: "hydrocinnamic acid metabolism" EXACT [] synonym: "phenylpropanoate metabolic process" EXACT [] synonym: "phenylpropanoate metabolism" EXACT [] xref: UM-BBD_pathwayID:ppa -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -142066,7 +142299,6 @@ def: "The chemical reactions and pathways involving toluene, a volatile monoarom synonym: "methylbenzene metabolic process" EXACT [] synonym: "methylbenzene metabolism" EXACT [] synonym: "toluene metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] @@ -142144,7 +142376,6 @@ synonym: "DDT metabolic process" EXACT [] synonym: "DDT metabolism" EXACT [] xref: UM-BBD_pathwayID:ddt is_a: GO:0017143 ! insecticide metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -142170,7 +142401,6 @@ synonym: "trichloroethene metabolic process" EXACT [] synonym: "trichloroethene metabolism" EXACT [] synonym: "trichloroethylene metabolism" EXACT [] xref: UM-BBD_pathwayID:tce -is_a: GO:0017144 ! drug metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] @@ -142182,8 +142412,6 @@ synonym: "2,4,5-T metabolic process" EXACT [] synonym: "2,4,5-T metabolism" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:2\,4\,5-t -is_a: GO:0006805 ! xenobiotic metabolic process -is_a: GO:0009850 ! auxin metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -142210,7 +142438,6 @@ synonym: "vanillic aldehyde metabolism" EXACT [] synonym: "vanillin metabolism" EXACT [] xref: UM-BBD_pathwayID:van is_a: GO:0006081 ! cellular aldehyde metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -143367,6 +143594,7 @@ def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.29] xref: EC:1.2.1.29 xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN +xref: RHEA:11804 xref: UM-BBD_reactionID:r0394 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity @@ -143538,8 +143766,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9] synonym: "tripeptidyl-peptidase I activity" EXACT [] -xref: EC:3.4.14.9 -xref: MetaCyc:3.4.14.9-RXN is_obsolete: true replaced_by: GO:0008240 @@ -143555,8 +143781,6 @@ synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102] synonym: "protease Re" RELATED [EC:3.4.21.102] synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102] synonym: "Tsp protease" NARROW [EC:3.4.21.102] -xref: EC:3.4.21.102 -xref: MetaCyc:3.4.21.102-RXN is_obsolete: true replaced_by: GO:0004252 @@ -143568,6 +143792,7 @@ def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = be synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" EXACT [EC:1.14.15.7] xref: EC:1.14.15.7 xref: MetaCyc:RXN1F-357 +xref: RHEA:17769 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] @@ -143595,6 +143820,7 @@ synonym: "DOHH activity" EXACT [EC:1.14.99.29] xref: EC:1.14.99.29 xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN xref: Reactome:R-HSA-204662 "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A" +xref: RHEA:14101 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen @@ -143613,6 +143839,7 @@ synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145] xref: EC:2.7.1.145 xref: MetaCyc:2.7.1.145-RXN +xref: RHEA:12140 is_a: GO:0019206 ! nucleoside kinase activity relationship: part_of GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process @@ -143970,6 +144197,7 @@ synonym: "diamine-ketoglutaric transaminase activity" EXACT [EC:2.6.1.29] synonym: "diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.29] xref: EC:2.6.1.29 xref: MetaCyc:DIAMTRANSAM-RXN +xref: RHEA:18217 is_a: GO:0008483 ! transaminase activity [Term] @@ -144017,6 +144245,7 @@ synonym: "pyruvic-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] xref: EC:1.2.7.1 xref: KEGG_REACTION:R01196 xref: MetaCyc:PYRUFLAVREDUCT-RXN +xref: RHEA:12765 is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor relationship: part_of GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate @@ -144050,6 +144279,7 @@ xref: MetaCyc:TRANSENOYLCOARED-RXN xref: Reactome:R-HSA-6786720 "DECR2 reduces LCtE-CoA to t3enoyl-CoA" xref: Reactome:R-HSA-6809810 "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA" xref: Reactome:R-HSA-8952873 "MECR dimer reduces tdec2-CoA to DEC-CoA" +xref: RHEA:33763 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -144058,6 +144288,7 @@ name: 2-octaprenylphenol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN] xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN +xref: RHEA:27790 is_a: GO:0016491 ! oxidoreductase activity [Term] @@ -144089,11 +144320,13 @@ is_a: GO:0016836 ! hydro-lyase activity id: GO:0019172 name: glyoxalase III activity namespace: molecular_function -def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [EC:4.2.1.130, GOC:mcc, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130, MetaCyc:GLYOXIII-RXN, PMID:21696459, PMID:7848303, RHEA:27754] +def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [GOC:mcc, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130, PMID:21696459, PMID:7848303, RHEA:27754] comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC:4.4.1.5 (lactoylglutathione lyase) and EC:3.1.2.6 (hydroxyacylglutathione hydrolase). synonym: "(R)-lactate hydro-lyase" EXACT [] synonym: "D-lactate dehydratase" EXACT [] synonym: "glutathione-independent glyoxalase activity" RELATED [] +xref: EC:4.2.1.130 +xref: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130 xref: MetaCyc:GLYOXIII-RXN xref: RHEA:27754 is_a: GO:0016836 ! hydro-lyase activity @@ -144115,6 +144348,7 @@ namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN] synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT [] xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN +xref: RHEA:25306 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] @@ -144123,6 +144357,7 @@ name: dihydroneopterin triphosphate pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN] xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN +xref: RHEA:25302 is_a: GO:0016462 ! pyrophosphatase activity [Term] @@ -144180,8 +144415,6 @@ name: histamine-gated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005254 ! chloride channel activity -is_a: GO:0022835 ! transmitter-gated channel activity -is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0019183 @@ -144189,7 +144422,7 @@ name: histamine-gated chloride channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034707 ! chloride channel complex -is_a: GO:0098878 ! neurotransmitter receptor complex +is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] @@ -144271,7 +144504,6 @@ id: GO:0019198 name: transmembrane receptor protein phosphatase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate." [GOC:hjd] -xref: EC:3.1.3 is_a: GO:0004721 ! phosphoprotein phosphatase activity is_a: GO:0004888 ! transmembrane signaling receptor activity @@ -144847,7 +145079,6 @@ synonym: "acrylonitrile breakdown" EXACT [] synonym: "acrylonitrile catabolism" EXACT [] synonym: "acrylonitrile degradation" EXACT [] xref: MetaCyc:P344-PWY -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018865 ! acrylonitrile metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0050899 ! nitrile catabolic process @@ -144899,7 +145130,6 @@ synonym: "1,4-dichlorobenzene degradation" EXACT [] xref: MetaCyc:14DICHLORBENZDEG-PWY is_a: GO:0018912 ! 1,4-dichlorobenzene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process -is_a: GO:0046701 ! insecticide catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] @@ -144912,10 +145142,9 @@ synonym: "N-acetylneuraminate catabolism" EXACT [] synonym: "N-acetylneuraminate degradation" EXACT [] xref: MetaCyc:P441-PWY is_a: GO:0006054 ! N-acetylneuraminate metabolic process -is_a: GO:0017001 ! antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046348 ! amino sugar catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0019263 @@ -145018,7 +145247,6 @@ synonym: "aerobactin synthesis" EXACT [] xref: MetaCyc:AEROBACTINSYN-PWY is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046442 ! aerobactin metabolic process -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process [Term] @@ -145027,7 +145255,6 @@ name: aerobactin transport namespace: biological_process def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai, PMID:23192658] is_a: GO:0006842 ! tricarboxylic acid transport -is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport [Term] @@ -145257,7 +145484,6 @@ synonym: "siderophore synthesis" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0019292 @@ -145318,7 +145544,6 @@ synonym: "coenzyme M biosynthesis" EXACT [] synonym: "coenzyme M formation" EXACT [] synonym: "coenzyme M synthesis" EXACT [] xref: MetaCyc:P261-PWY -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019296 ! coenzyme M metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process @@ -145330,7 +145555,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] synonym: "coenzyme M metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] @@ -145340,7 +145564,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] synonym: "coenzyme B metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process @@ -145354,7 +145577,6 @@ synonym: "coenzyme B biosynthesis" EXACT [] synonym: "coenzyme B formation" EXACT [] synonym: "coenzyme B synthesis" EXACT [] xref: MetaCyc:P241-PWY -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019297 ! coenzyme B metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process @@ -145809,7 +146031,6 @@ synonym: "pentachlorophenol breakdown" EXACT [] synonym: "pentachlorophenol catabolism" EXACT [] synonym: "pentachlorophenol degradation" EXACT [] xref: MetaCyc:PCPDEG-PWY -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018961 ! pentachlorophenol metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process @@ -145825,8 +146046,6 @@ xref: MetaCyc:PARATHION-DEGRADATION-PWY is_a: GO:0018952 ! parathion metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046434 ! organophosphate catabolic process -is_a: GO:0046701 ! insecticide catabolic process -is_a: GO:0051410 ! detoxification of nitrogen compound [Term] id: GO:0019340 @@ -146105,7 +146324,6 @@ synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT [] xref: MetaCyc:P2-PWY -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process @@ -146115,7 +146333,6 @@ name: pyridine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] synonym: "pyridine nucleotide metabolism" EXACT [] -is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process @@ -146129,7 +146346,6 @@ synonym: "pyridine nucleotide biosynthesis" EXACT [] synonym: "pyridine nucleotide formation" EXACT [] synonym: "pyridine nucleotide synthesis" EXACT [] xref: MetaCyc:PYRIDNUCSYN-PWY -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process @@ -146142,7 +146358,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of a pyridi synonym: "pyridine nucleotide breakdown" EXACT [] synonym: "pyridine nucleotide catabolism" EXACT [] synonym: "pyridine nucleotide degradation" EXACT [] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process @@ -146282,7 +146497,6 @@ synonym: "3-phenylpropionate catabolism" EXACT [] synonym: "3-phenylpropionate degradation" EXACT [] xref: MetaCyc:HCAMHPDEG-PWY xref: MetaCyc:P281-PWY -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018962 ! 3-phenylpropionate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process @@ -146481,7 +146695,6 @@ synonym: "gallic acid catabolic process" EXACT [] synonym: "gallic acid catabolism" EXACT [] is_a: GO:0018918 ! gallate metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] @@ -146668,7 +146881,6 @@ synonym: "acetate biosynthesis" EXACT [] synonym: "acetate formation" EXACT [] synonym: "acetate synthesis" EXACT [] is_a: GO:0006083 ! acetate metabolic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] @@ -146690,7 +146902,6 @@ synonym: "acetate formation from carbon monoxide" EXACT [] synonym: "acetate synthesis from carbon monoxide" EXACT [] synonym: "carbon monoxide dehydrogenase pathway" EXACT [] is_a: GO:0019413 ! acetate biosynthetic process -is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0019416 @@ -146825,7 +147036,6 @@ xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY is_a: GO:0018917 ! fluorene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] @@ -147348,7 +147558,6 @@ synonym: "L-lysine breakdown" EXACT [] synonym: "L-lysine catabolism" EXACT [] synonym: "L-lysine degradation" EXACT [] is_a: GO:0006554 ! lysine catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046440 ! L-lysine metabolic process [Term] @@ -147398,7 +147607,6 @@ def: "The chemical reactions and pathways involving beta-alanine (3-aminopropano synonym: "beta-alanine metabolism" EXACT [] xref: Wikipedia:Beta-alanine is_a: GO:0006520 ! cellular amino acid metabolic process -is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0019483 @@ -147411,7 +147619,6 @@ synonym: "beta-alanine formation" EXACT [] synonym: "beta-alanine synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0019482 ! beta-alanine metabolic process -is_a: GO:0042136 ! neurotransmitter biosynthetic process [Term] id: GO:0019484 @@ -147423,7 +147630,6 @@ synonym: "beta-alanine catabolism" EXACT [] synonym: "beta-alanine degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0019482 ! beta-alanine metabolic process -is_a: GO:0042135 ! neurotransmitter catabolic process [Term] id: GO:0019485 @@ -147716,7 +147922,6 @@ is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process -is_a: GO:0051187 ! cofactor catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] @@ -147790,7 +147995,6 @@ synonym: "threonine catabolic process to D-lactate" BROAD [GOC:bf] xref: MetaCyc:THRDLCTCAT-PWY is_a: GO:0006089 ! lactate metabolic process is_a: GO:0006567 ! threonine catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019518 @@ -147805,7 +148009,6 @@ synonym: "threonine catabolic process to glycine" BROAD [GOC:bf] xref: MetaCyc:THREONINE-DEG2-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0006567 ! threonine catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019519 @@ -147916,7 +148119,6 @@ synonym: "taurine catabolism" EXACT [] synonym: "taurine degradation" EXACT [] xref: MetaCyc:TAURINEDEG-PWY is_a: GO:0019530 ! taurine metabolic process -is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046306 ! alkanesulfonate catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process @@ -147926,7 +148128,6 @@ name: taurine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] synonym: "taurine metabolism" EXACT [] -is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0019694 ! alkanesulfonate metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process @@ -148001,7 +148202,6 @@ is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019536 ! vibriobactin metabolic process is_a: GO:0043604 ! amide biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process @@ -148068,7 +148268,6 @@ def: "The chemical reactions and pathways involving propionate, the anion derive synonym: "propanoate metabolic process" EXACT [] synonym: "propanoate metabolism" EXACT [] synonym: "propionate metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] @@ -148080,7 +148279,6 @@ synonym: "propionate anabolism" EXACT [] synonym: "propionate biosynthesis" EXACT [] synonym: "propionate formation" EXACT [] synonym: "propionate synthesis" EXACT [] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0051790 ! short-chain fatty acid biosynthetic process @@ -148092,10 +148290,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of propiona synonym: "propionate breakdown" EXACT [] synonym: "propionate catabolism" EXACT [] synonym: "propionate degradation" EXACT [] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019626 ! short-chain fatty acid catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019544 @@ -148651,7 +148847,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of mandelat synonym: "mandelate breakdown" EXACT [] synonym: "mandelate catabolism" EXACT [] synonym: "mandelate degradation" EXACT [] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018924 ! mandelate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process @@ -148665,7 +148860,6 @@ namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators] synonym: "(R)-mandelate breakdown to benzoate" EXACT [] synonym: "(R)-mandelate degradation to benzoate" EXACT [] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018874 ! benzoate metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019596 ! mandelate catabolic process @@ -148787,8 +148981,8 @@ synonym: "nicotine catabolism" EXACT [] synonym: "nicotine degradation" EXACT [] xref: MetaCyc:P181-PWY xref: UM-BBD_pathwayID:nic +is_a: GO:0009056 ! catabolic process is_a: GO:0018933 ! nicotine metabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019609 @@ -148912,7 +149106,6 @@ synonym: "protocatechuate catabolic process" EXACT [] synonym: "protocatechuate catabolism" EXACT [] synonym: "protocatechuate degradation" EXACT [] is_a: GO:0019614 ! catechol-containing compound catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process @@ -149110,7 +149303,6 @@ def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a synonym: "phosphonoacetate metabolism" EXACT [] xref: MetaCyc:P483-PWY is_a: GO:0006793 ! phosphorus metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] @@ -149255,7 +149447,6 @@ def: "The anaerobic chemical reactions and pathways resulting in the breakdown o synonym: "citrate fermentation to diacetyl" EXACT [] synonym: "diacetyl fermentation" EXACT [] is_a: GO:0006101 ! citrate metabolic process -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019662 ! non-glycolytic fermentation is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process @@ -149728,7 +149919,6 @@ name: choline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] synonym: "choline metabolism" EXACT [] -is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0071704 ! organic substance metabolic process is_a: GO:0097164 ! ammonium ion metabolic process @@ -149839,6 +150029,7 @@ synonym: "protein-cysteine S-palmitoleyltransferase activity" RELATED [] xref: EC:2.3.1.225 xref: Reactome:R-HSA-5682084 "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer" xref: Reactome:R-HSA-9021072 "ZDHHC7, ZDHHC21 palmitoylate ESR1" +xref: Reactome:R-HSA-9647982 "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated" xref: RHEA:36683 is_a: GO:0016409 ! palmitoyltransferase activity is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity @@ -150205,6 +150396,7 @@ subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant +subset: goslim_pombe synonym: "secondary metabolism" EXACT [] synonym: "secondary metabolite metabolic process" EXACT [] synonym: "secondary metabolite metabolism" EXACT [] @@ -150629,6 +150821,7 @@ xref: Reactome:R-HSA-3000399 "RANBP2 SUMOylates SP100 with SUMO1" xref: Reactome:R-HSA-3000411 "RANBP2 SUMOylates PML with SUMO2" xref: Reactome:R-HSA-3000433 "SUMOylation of PML with SUMO3" xref: Reactome:R-HSA-3000434 "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1" +xref: Reactome:R-HSA-3000449 "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2" xref: Reactome:R-HSA-3108203 "PRC1 SUMOylates CTBP1 with SUMO2,3" xref: Reactome:R-HSA-3108209 "PRC1 SUMOylates CTBP1 with SUMO1" xref: Reactome:R-HSA-3108212 "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1" @@ -150845,6 +151038,7 @@ xref: EC:1.14.11.7 xref: KEGG_REACTION:R03218 xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN xref: Reactome:R-HSA-1980233 "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen" +xref: RHEA:22872 is_a: GO:0019798 ! procollagen-proline dioxygenase activity is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity @@ -150870,6 +151064,7 @@ synonym: "TAT activity" EXACT [EC:2.3.1.108] synonym: "tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] xref: EC:2.3.1.108 xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN +xref: RHEA:15277 is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity [Term] @@ -151122,7 +151317,6 @@ subset: goslim_pir subset: goslim_plant synonym: "cytochrome P450" NARROW [] synonym: "cytochrome P450 activity" RELATED [] -is_a: GO:0008144 ! drug binding is_a: GO:0036094 ! small molecule binding [Term] @@ -151383,7 +151577,6 @@ synonym: "L-ascorbic acid metabolism" EXACT [] synonym: "vitamin C metabolic process" EXACT [] synonym: "vitamin C metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process @@ -151401,7 +151594,6 @@ synonym: "L-ascorbic acid synthesis" EXACT [] synonym: "vitamin C biosynthesis" EXACT [] synonym: "vitamin C biosynthetic process" EXACT [] xref: MetaCyc:PWY-882 -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0046364 ! monosaccharide biosynthetic process @@ -151420,7 +151612,6 @@ synonym: "L-ascorbic acid degradation" EXACT [] synonym: "vitamin C catabolic process" EXACT [] synonym: "vitamin C catabolism" EXACT [] xref: MetaCyc:PWY0-301 -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0046365 ! monosaccharide catabolic process @@ -151481,7 +151672,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] synonym: "uracil metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process -is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0019861 @@ -152410,8 +152600,8 @@ is_a: GO:0019961 ! interferon binding id: GO:0019964 name: interferon-gamma binding namespace: molecular_function -def: "Interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383, PR:000000017] -synonym: "IFN-gamma binding" EXACT [GOC:mah, PR:000000017] +def: "Interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383] +synonym: "IFN-gamma binding" EXACT [GOC:mah] synonym: "IFNG binding" EXACT [GOC:mah] synonym: "type II interferon binding" BROAD [PMID:15546383, PR:000024990] is_a: GO:0019961 ! interferon binding @@ -152897,7 +153087,6 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai] synonym: "haem binding" EXACT [] is_a: GO:0046906 ! tetrapyrrole binding -is_a: GO:0048037 ! cofactor binding [Term] id: GO:0020038 @@ -158401,7 +158590,8 @@ comment: Note that this term represents an activity and not a gene product. Cons synonym: "5-hydroxytryptamine-gated receptor-channel" NARROW [] synonym: "serotonin-activated cation-selective channel activity" EXACT [] synonym: "serotonin-gated cation channel activity" NARROW [] -xref: Reactome:R-HSA-975311 "HTR3 pentamer:5HT transports Na+,K+, and Ca2+" +xref: Reactome:R-HSA-9648983 "HTR3A pentamer:5HT transports Na+,K+,Ca2+" +xref: Reactome:R-HSA-975311 "HTR3 pentamers:5HT transport Na+,K+,Ca2+" is_a: GO:0022824 ! transmitter-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity relationship: part_of GO:0007210 ! serotonin receptor signaling pathway @@ -158620,6 +158810,7 @@ namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sucrose PTS transporter activity" EXACT [] xref: MetaCyc:SUCROSEPHOSPHO-RXN +xref: RHEA:49236 is_a: GO:0008515 ! sucrose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity @@ -159654,8 +159845,6 @@ synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59] synonym: "skin tryptase activity" NARROW [EC:3.4.21.59] synonym: "tryptase activity" EXACT [] synonym: "tryptase M" RELATED [EC:3.4.21.59] -xref: EC:3.4.21.59 -xref: MetaCyc:3.4.21.59-RXN is_obsolete: true replaced_by: GO:0004252 @@ -160004,6 +160193,7 @@ synonym: "dehydrogenase, arylamine (azurin) activity" EXACT [EC:1.4.9.2] synonym: "tyramine dehydrogenase (azurin) activity" NARROW [EC:1.4.9.2] xref: EC:1.4.9.2 xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN +xref: RHEA:47796 is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor [Term] @@ -160986,6 +161176,7 @@ synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" EXACT [EC xref: EC:2.4.2.26 xref: MetaCyc:2.4.2.26-RXN xref: Reactome:R-HSA-1878002 "XYLTs transfer Xyl to core protein" +xref: RHEA:50192 is_a: GO:0035252 ! UDP-xylosyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -160999,6 +161190,7 @@ synonym: "receptor signaling complex scaffold activity" EXACT [] synonym: "receptor signaling complex scaffold protein activity" EXACT [] synonym: "receptor signalling complex scaffold activity" EXACT [] is_a: GO:0035591 ! signaling adaptor activity +relationship: has_part GO:0005102 ! signaling receptor binding [Term] id: GO:0030160 @@ -161119,7 +161311,6 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] subset: goslim_metagenomics is_a: GO:0043168 ! anion binding -is_a: GO:0050662 ! coenzyme binding is_a: GO:0070279 ! vitamin B6 binding [Term] @@ -161292,7 +161483,6 @@ id: GO:0030184 name: nitric oxide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah] -is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity relationship: part_of GO:0030185 ! nitric oxide transport @@ -161301,8 +161491,6 @@ id: GO:0030185 name: nitric oxide transport namespace: biological_process def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] -is_a: GO:0006836 ! neurotransmitter transport -is_a: GO:0015893 ! drug transport is_a: GO:0071705 ! nitrogen compound transport [Term] @@ -161311,7 +161499,6 @@ name: melatonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] synonym: "melatonin metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process @@ -161552,7 +161739,6 @@ synonym: "dermatan sulfate metabolism" EXACT [] synonym: "dermatan sulphate metabolic process" EXACT [] synonym: "dermatan sulphate metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process @@ -161620,7 +161806,6 @@ synonym: "dermatan sulphate catabolic process" EXACT [] synonym: "dermatan sulphate catabolism" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030205 ! dermatan sulfate metabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process @@ -162274,8 +162459,6 @@ synonym: "SK protease activity" EXACT [EC:3.4.21.39] synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39] synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39] synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39] -xref: EC:3.4.21.39 -xref: MetaCyc:3.4.21.39-RXN is_obsolete: true replaced_by: GO:0004252 @@ -162587,8 +162770,6 @@ synonym: "MMP-10" EXACT [] synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22] synonym: "stromelysin 2 activity" EXACT [] synonym: "transin 2 activity" EXACT [EC:3.4.24.22] -xref: EC:3.4.24.22 -xref: MetaCyc:3.4.24.22-RXN is_obsolete: true replaced_by: GO:0004222 @@ -162743,12 +162924,18 @@ is_a: GO:0002573 ! myeloid leukocyte differentiation id: GO:0030317 name: flagellated sperm motility namespace: biological_process -def: "Any process involved in the controlled movement of a flagellated sperm cell." [GOC:cilia, GOC:jl, GOC:krc] +alt_id: GO:0097724 +alt_id: GO:1905419 +def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031] synonym: "flagellated sperm movement" EXACT [] +synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc] +synonym: "sperm flagellum movement involved in flagellated sperm motility" EXACT [] +synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie] synonym: "sperm motility" BROAD [] synonym: "sperm movement" BROAD [] xref: Wikipedia:Sperm_motility is_a: GO:0060285 ! cilium-dependent cell motility +is_a: GO:0060294 ! cilium movement involved in cell motility is_a: GO:0097722 ! sperm motility [Term] @@ -162953,6 +163140,7 @@ synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity synonym: "N-acetylneuraminic monooxygenase activity" EXACT [EC:1.14.18.2] xref: EC:1.14.18.2 xref: MetaCyc:1.14.13.45-RXN +xref: RHEA:16145 is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] @@ -162966,6 +163154,7 @@ synonym: "fatty-acyl ethyl ester synthase" EXACT [GOC:mah] synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" EXACT [EC:3.1.1.67] xref: EC:3.1.1.67 xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN +xref: RHEA:16641 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] @@ -162980,6 +163169,7 @@ synonym: "mucinase activity" EXACT [EC:4.2.2.1] synonym: "spreading factor activity" RELATED [EC:4.2.2.1] xref: EC:4.2.2.1 xref: MetaCyc:HYALURONATE-LYASE-RXN +xref: RHEA:50240 is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] @@ -163018,6 +163208,7 @@ synonym: "cholecalciferol 25-hydroxylase activity" EXACT [] xref: MetaCyc:RXN-9829 xref: Reactome:R-HSA-209845 "CYP2R1 25-hydroxylates VD3 to 25(OH)D" xref: Reactome:R-HSA-5602147 "Defective CYP2R1 does not 25-hydroxylate vitamin D" +xref: RHEA:32903 is_a: GO:0070643 ! vitamin D 25-hydroxylase activity relationship: part_of GO:0036378 ! calcitriol biosynthetic process from calciol @@ -163057,7 +163248,6 @@ id: GO:0030351 name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] -xref: EC:3.1.3 xref: Reactome:R-HSA-1855163 "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen" is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity @@ -163066,7 +163256,6 @@ id: GO:0030352 name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai] -xref: EC:3.1.3 is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity [Term] @@ -163153,6 +163342,7 @@ namespace: molecular_function def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783] xref: EC:2.8.1.12 xref: Reactome:R-HSA-947541 "Sulfhydrylation and ring cleavage of precursor Z" +xref: RHEA:26333 is_a: GO:0016783 ! sulfurtransferase activity [Term] @@ -163267,7 +163457,8 @@ namespace: molecular_function def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd] xref: EC:5.1.1.18 xref: MetaCyc:5.1.1.18-RXN -xref: Reactome:R-HSA-9014766 "SRR dimer:PXLP isomerises L-Ser to D-Ser" +xref: Reactome:R-HSA-9014766 "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser" +xref: RHEA:10980 is_a: GO:0047661 ! amino-acid racemase activity [Term] @@ -163477,7 +163668,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "matrilysin-2 activity" EXACT [] synonym: "matrix metalloproteinase 26" EXACT [] synonym: "MMP-26" EXACT [] -xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 @@ -163563,6 +163753,7 @@ synonym: "glutamate formiminotransferase activity" EXACT [] synonym: "glutamate formyltransferase activity" EXACT [EC:2.1.2.5] xref: EC:2.1.2.5 xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN +xref: RHEA:15097 is_a: GO:0030407 ! formimidoyltransferase activity [Term] @@ -163652,7 +163843,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] synonym: "nicotianamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -163682,7 +163872,6 @@ synonym: "nicotianamine catabolism" EXACT [] synonym: "nicotianamine degradation" EXACT [] is_a: GO:0030417 ! nicotianamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -164440,7 +164629,7 @@ id: GO:0030509 name: BMP signaling pathway namespace: biological_process alt_id: GO:0008101 -def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827, PR:000000034] +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827] synonym: "BMP receptor signaling pathway" RELATED [] synonym: "BMP signalling pathway" EXACT [] synonym: "bone morphogenetic protein signaling pathway" EXACT [] @@ -165104,6 +165293,7 @@ synonym: "bile acid catabolism" EXACT [] synonym: "bile acid degradation" EXACT [] synonym: "cholate catabolic process" NARROW [] xref: MetaCyc:7ALPHADEHYDROX-PWY +is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process @@ -165265,6 +165455,7 @@ synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ ox xref: EC:1.16.1.8 xref: MetaCyc:2.1.1.135-RXN xref: Reactome:R-HSA-3149518 "MTRR reduces cob(II)alamin to meCbl" +xref: RHEA:23908 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] @@ -165399,6 +165590,7 @@ synonym: "pectin pectylhydrolase activity" EXACT [EC:3.1.1.11] synonym: "pectinoesterase activity" EXACT [EC:3.1.1.11] xref: EC:3.1.1.11 xref: MetaCyc:PECTINESTERASE-RXN +xref: RHEA:22380 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] @@ -165432,8 +165624,6 @@ synonym: "arylamidase II" RELATED [EC:3.4.11.6] synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6] synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6] synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6] -xref: EC:3.4.11.6 -xref: MetaCyc:3.4.11.6-RXN is_obsolete: true replaced_by: GO:0004177 @@ -165446,8 +165636,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "chymosin activity" EXACT [] synonym: "rennin" RELATED [EC:3.4.23.4] synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4] -xref: EC:3.4.23.4 -xref: MetaCyc:3.4.23.4-RXN is_obsolete: true replaced_by: GO:0004190 @@ -165819,7 +166007,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] synonym: "aminoglycoside antibiotic metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process -is_a: GO:0016999 ! antibiotic metabolic process [Term] id: GO:0030648 @@ -165939,7 +166126,6 @@ def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the comment: This term was made obsolete because it was replaced by more specific terms. synonym: "regulation of coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true -consider: GO:0051196 consider: GO:0051199 [Term] @@ -166093,14 +166279,14 @@ relationship: part_of GO:0044304 ! main axon id: GO:0030674 name: protein-macromolecule adaptor activity namespace: molecular_function -def: "The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] +def: "The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "protein binding, bridging" EXACT [] synonym: "protein-protein adaptor" NARROW [] -is_a: GO:0005515 ! protein binding is_a: GO:0060090 ! molecular adaptor activity +relationship: has_part GO:0005515 ! protein binding property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18655 xsd:anyURI [Term] @@ -166372,6 +166558,7 @@ synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35] xref: EC:2.1.1.35 xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN +xref: RHEA:42712 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity @@ -166417,6 +166604,7 @@ synonym: "NAD-azoferredoxin (ADPribose)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.37 xref: MetaCyc:2.4.2.37-RXN +xref: RHEA:18077 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] @@ -166762,6 +166950,7 @@ synonym: "fatty-acid O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" EXACT [EC:2.1.1.15] xref: EC:2.1.1.15 xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN +xref: RHEA:23012 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -166945,6 +167134,7 @@ synonym: "isoflavone O-methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.46] xref: EC:2.1.1.46 xref: MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN +xref: RHEA:31739 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -167032,6 +167222,7 @@ synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" EXACT synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" EXACT [EC:2.1.1.69] xref: EC:2.1.1.69 xref: MetaCyc:2.1.1.69-RXN +xref: RHEA:11808 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -167330,6 +167521,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-gluc synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" EXACT [EC:2.1.1.112] xref: EC:2.1.1.112 xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN +xref: RHEA:20413 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -167453,6 +167645,7 @@ synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizin synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.127] xref: EC:2.1.1.127 xref: MetaCyc:2.1.1.127-RXN +xref: RHEA:50996 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -167518,6 +167711,7 @@ synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" synonym: "trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] xref: EC:2.1.1.136 xref: MetaCyc:2.1.1.136-RXN +xref: RHEA:18909 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -167533,6 +167727,7 @@ xref: EC:2.1.1.137 xref: MetaCyc:2.1.1.137-RXN xref: Reactome:R-HSA-5696213 "AS3MT transfers CH3 from AdoMet to methylarsonite" xref: Reactome:R-HSA-5696220 "AS3MT transfers CH3 from AdoMet to arsenite(3-)" +xref: RHEA:15293 xref: UM-BBD_reactionID:r0805 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity @@ -169680,7 +169875,6 @@ is_a: GO:0015695 ! organic cation transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0045117 ! azole transmembrane transport -is_a: GO:0051181 ! cofactor transport is_a: GO:0072348 ! sulfur compound transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport is_a: GO:0098655 ! cation transmembrane transport @@ -169693,7 +169887,6 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg] synonym: "thiamin binding" EXACT [] synonym: "vitamin B1 binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding @@ -169712,7 +169905,6 @@ synonym: "TPP binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0043168 ! anion binding is_a: GO:0043169 ! cation binding -is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding @@ -169940,16 +170132,14 @@ def: "The cell cycle process in which linear elements are assembled in associati synonym: "linear element formation" RELATED [GOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:1903046 ! meiotic cell cycle process -relationship: part_of GO:0007129 ! synapsis +relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis [Term] id: GO:0031000 name: response to caffeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:ef, GOC:mah] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014074 ! response to purine-containing compound -is_a: GO:0036270 ! response to diuretic is_a: GO:0043279 ! response to alkaloid [Term] @@ -170688,7 +170878,8 @@ synonym: "NIFS" RELATED [EC:2.8.1.7] synonym: "SufS" RELATED [EC:2.8.1.7] xref: EC:2.8.1.7 xref: Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster" -xref: Reactome:R-HSA-947514 "NFS1 transfers sulfur from cysteine onto MOCS3" +xref: Reactome:R-HSA-947514 "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3" +xref: RHEA:43892 is_a: GO:0016783 ! sulfurtransferase activity [Term] @@ -170764,7 +170955,6 @@ synonym: "protease 3C" RELATED [EC:3.4.22.28] synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28] synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28] -xref: EC:3.4.22.28 is_obsolete: true replaced_by: GO:0004197 @@ -171754,6 +171944,7 @@ namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O." [MetaCyc:RXN-11128, PMID:12828635] synonym: "L-ornithine 5-monooxygenase activity" EXACT [MetaCyc:RXN-11128] xref: MetaCyc:RXN-11128 +xref: RHEA:41508 is_a: GO:0004497 ! monooxygenase activity [Term] @@ -171816,7 +172007,6 @@ def: "Interacting selectively and non-covalently with phosphopantetheine, the vi is_a: GO:0019842 ! vitamin binding is_a: GO:0033218 ! amide binding is_a: GO:0043168 ! anion binding -is_a: GO:0048037 ! cofactor binding is_a: GO:0072341 ! modified amino acid binding [Term] @@ -171998,6 +172188,7 @@ namespace: molecular_function def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846] xref: MetaCyc:RXN-9025 xref: MetaCyc:RXN0-5182 +xref: RHEA:29691 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] @@ -174121,7 +174312,6 @@ name: lipoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732] is_a: GO:0005504 ! fatty acid binding -is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding @@ -174257,7 +174447,6 @@ synonym: "vitamin C binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0048029 ! monosaccharide binding -is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0031419 @@ -174265,10 +174454,8 @@ name: cobalamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] synonym: "vitamin B12 binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0046906 ! tetrapyrrole binding -is_a: GO:0048037 ! cofactor binding [Term] id: GO:0031420 @@ -174334,11 +174521,8 @@ id: GO:0031427 name: response to methotrexate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:ef, GOC:mah, ISBN:0198506732] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097327 ! response to antineoplastic agent -is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound [Term] @@ -174841,9 +175025,10 @@ is_a: GO:0043232 ! intracellular non-membrane-bounded organelle id: GO:0031470 name: carboxysome namespace: cellular_component -def: "An organelle consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708] +def: "An organelle consisting of a proteinaceous coat and enzymes for the fixation of CO(2). It augments the concentration of CO(2) in the vicinity of RuBisCO to increase the efficiency of CO(2) fixation under atmospheric conditions." [GOC:js, PMID:28934381, PMID:8157606, PMID:8491708] xref: Wikipedia:Carboxysome is_a: GO:0031469 ! polyhedral organelle +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19743 xsd:anyURI [Term] id: GO:0031471 @@ -175210,6 +175395,7 @@ synonym: "heterochromatic silencing at centromere" EXACT [] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0031055 ! chromatin remodeling at centromere is_a: GO:0031507 ! heterochromatin assembly +is_a: GO:0140462 ! pericentric heterochromatin organization relationship: part_of GO:0034508 ! centromere complex assembly property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18954 xsd:anyURI property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19112 xsd:anyURI @@ -175231,6 +175417,8 @@ synonym: "subtelomeric silencing" EXACT [GOC:mah] synonym: "telomeric heterochromatin assembly" RELATED [] synonym: "telomeric heterochromatin formation" RELATED [] is_a: GO:0031507 ! heterochromatin assembly +is_a: GO:0032202 ! telomere assembly +is_a: GO:0140461 ! subtelomeric heterochromatin organization relationship: part_of GO:0032200 ! telomere organization property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19188 xsd:anyURI property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19308 xsd:anyURI @@ -175360,7 +175548,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] synonym: "menthol metabolism" EXACT [] is_a: GO:0016098 ! monoterpenoid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] @@ -176612,6 +176799,7 @@ subset: goslim_pir synonym: "killing of cells of another organism" EXACT [GOC:bf] synonym: "killing of cells of another, non-host, organism" NARROW [] is_a: GO:0001906 ! cell killing +is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0031641 @@ -179022,7 +179210,6 @@ id: GO:0031919 name: vitamin B6 transport namespace: biological_process def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] -is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport @@ -179035,7 +179222,6 @@ def: "The directed movement of pyridoxal into, out of or within a cell, or betwe is_a: GO:0015695 ! organic cation transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport -is_a: GO:0051181 ! cofactor transport [Term] id: GO:0031921 @@ -179046,7 +179232,6 @@ is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport -is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0031922 @@ -179064,7 +179249,6 @@ namespace: biological_process def: "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport -is_a: GO:0051181 ! cofactor transport [Term] id: GO:0031924 @@ -179082,8 +179266,6 @@ namespace: molecular_function def: "Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxal transporter activity" BROAD [] is_a: GO:0015101 ! organic cation transmembrane transporter activity -is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:1903090 ! pyridoxal transmembrane transport @@ -179094,8 +179276,6 @@ namespace: molecular_function def: "Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity -is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity -is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] @@ -179104,7 +179284,6 @@ name: pyridoxamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0015101 ! organic cation transmembrane transporter activity -is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:1903091 ! pyridoxamine transmembrane transport @@ -179114,8 +179293,6 @@ name: pyridoxine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxine transporter activity" BROAD [] -is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:1903092 ! pyridoxine transmembrane transport @@ -180418,6 +180595,7 @@ id: GO:0032052 name: bile acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:rph] +is_a: GO:0005496 ! steroid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] @@ -182212,6 +182390,7 @@ namespace: molecular_function def: "Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] synonym: "riboflavin transporter activity" RELATED [] xref: Reactome:R-HSA-3165230 "SLC52A1,2,3 transport RIB from extracellular region to cytosol" +xref: RHEA:35015 is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0032218 ! riboflavin transport @@ -182222,7 +182401,6 @@ name: riboflavin transport namespace: biological_process def: "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] is_a: GO:0015711 ! organic anion transport -is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0071705 ! nitrogen compound transport @@ -182494,7 +182672,6 @@ name: adenosine transport namespace: biological_process def: "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015858 ! nucleoside transport -is_a: GO:0015893 ! drug transport [Term] id: GO:0032239 @@ -182629,7 +182806,6 @@ name: regulation of adenosine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032245 ! regulation of purine nucleoside transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032238 ! adenosine transport relationship: regulates GO:0032238 ! adenosine transport @@ -182645,7 +182821,6 @@ synonym: "downregulation of adenosine transport" EXACT [] synonym: "inhibition of adenosine transport" NARROW [] is_a: GO:0032247 ! negative regulation of purine nucleoside transport is_a: GO:0032249 ! regulation of adenosine transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032238 ! adenosine transport relationship: negatively_regulates GO:0032238 ! adenosine transport @@ -182662,7 +182837,6 @@ synonym: "up-regulation of adenosine transport" EXACT [] synonym: "upregulation of adenosine transport" EXACT [] is_a: GO:0032248 ! positive regulation of purine nucleoside transport is_a: GO:0032249 ! regulation of adenosine transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032238 ! adenosine transport relationship: positively_regulates GO:0032238 ! adenosine transport @@ -183312,7 +183486,7 @@ name: icosanoid secretion namespace: biological_process def: "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue." [GOC:mah] synonym: "eicosanoid secretion" EXACT [] -is_a: GO:0046717 ! acid secretion +is_a: GO:0046903 ! secretion is_a: GO:0071715 ! icosanoid transport [Term] @@ -183372,7 +183546,6 @@ synonym: "molybdopterin cofactor synthesis" EXACT [] xref: MetaCyc:Molybdenum-Cofactor-Biosynthesis is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043545 ! molybdopterin cofactor metabolic process -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process @@ -183390,7 +183563,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of the moly is_a: GO:0043545 ! molybdopterin cofactor metabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0046700 ! heterocycle catabolic process -is_a: GO:0051187 ! cofactor catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process @@ -183417,7 +183589,6 @@ synonym: "Moco catabolism" BROAD [] synonym: "W-molybdopterin cofactor breakdown" EXACT [] synonym: "W-molybdopterin cofactor catabolism" EXACT [] synonym: "W-molybdopterin cofactor degradation" EXACT [] -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0032325 ! molybdopterin cofactor catabolic process is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process @@ -183798,7 +183969,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123] synonym: "response to E2 stimulus" EXACT [] synonym: "response to estradiol stimulus" EXACT [GOC:dos] -is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound @@ -183844,7 +184014,6 @@ id: GO:0032361 name: pyridoxal phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042820 ! vitamin B6 catabolic process is_a: GO:0042822 ! pyridoxal phosphate metabolic process @@ -183869,7 +184038,6 @@ id: GO:0032363 name: FMN catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009261 ! ribonucleotide catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process @@ -185356,7 +185524,6 @@ id: GO:0032495 name: response to muramyl dipeptide namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add] -is_a: GO:0042493 ! response to drug is_a: GO:1901652 ! response to peptide [Term] @@ -185400,7 +185567,6 @@ id: GO:0032500 name: muramyl dipeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl] -is_a: GO:0008144 ! drug binding is_a: GO:0042277 ! peptide binding is_a: GO:0097367 ! carbohydrate derivative binding @@ -185635,7 +185801,6 @@ name: response to retinoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl] synonym: "response to vitamin A acid" EXACT [] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound @@ -185814,6 +185979,7 @@ synonym: "Srx1" RELATED [EC:1.8.98.2] synonym: "sulphiredoxin activity" EXACT [] xref: EC:1.8.98.2 xref: MetaCyc:1.8.98.2-RXN +xref: RHEA:17545 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors @@ -186044,7 +186210,6 @@ name: response to progesterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl] synonym: "response to progesterone stimulus" EXACT [GOC:dos] -is_a: GO:0042493 ! response to drug is_a: GO:0048545 ! response to steroid hormone is_a: GO:1901654 ! response to ketone @@ -186070,7 +186235,6 @@ name: response to phylloquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl] synonym: "response to vitamin K1" EXACT [] -is_a: GO:0033273 ! response to vitamin is_a: GO:1901654 ! response to ketone [Term] @@ -186082,6 +186246,7 @@ def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction driv synonym: "5' to 3' RNA helicase activity" EXACT [] synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT [] synonym: "ATP-dependent 5'-3' RNA helicase activity" EXACT [] +xref: Reactome:R-HSA-9682695 "nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template" is_a: GO:0003724 ! RNA helicase activity [Term] @@ -186333,8 +186498,21 @@ is_a: GO:0001816 ! cytokine production id: GO:0032603 name: fractalkine production namespace: biological_process -def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +alt_id: GO:0050751 +alt_id: GO:0050754 +def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:12729461] +synonym: "ABCD-3 production" EXACT [] +synonym: "CX3C membrane-anchored chemokine production" EXACT [] +synonym: "CX3CL1 production" EXACT [] +synonym: "fractalkine biosynthetic process" NARROW [] +synonym: "positive regulation of CX3CL1 biosynthesis" NARROW [] +synonym: "positive regulation of fractalkine biosynthesis" NARROW [] +synonym: "positive regulation of fractalkine biosynthetic process" NARROW [] +synonym: "positive regulation of fractalkine formation" NARROW [] +synonym: "positive regulation of fractalkine synthesis" NARROW [] +synonym: "stimulation of fractalkine biosynthetic process" NARROW [] is_a: GO:0032602 ! chemokine production +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19254 xsd:anyURI [Term] id: GO:0032604 @@ -186356,35 +186534,49 @@ is_a: GO:0001816 ! cytokine production id: GO:0032606 name: type I interferon production namespace: biological_process +alt_id: GO:0045351 def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon type I production" EXACT [] synonym: "type I IFN production" EXACT [] +synonym: "type I interferon biosynthetic process" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032607 name: interferon-alpha production namespace: biological_process -def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +alt_id: GO:0045349 +alt_id: GO:0072642 +def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383] synonym: "IFN-alpha production" EXACT [GOC:mah] synonym: "IFNA production" EXACT [GOC:mah] +synonym: "interferon-alpha biosynthetic process" NARROW [] +synonym: "interferon-alpha secretion" NARROW [] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0032608 name: interferon-beta production namespace: biological_process -def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +alt_id: GO:0035546 +alt_id: GO:0045350 +def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383] synonym: "IFN-beta production" EXACT [] synonym: "IFNB production" EXACT [GOC:mah] +synonym: "interferon-beta biosynthetic process" NARROW [] +synonym: "interferon-beta secretion" NARROW [] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0032609 name: interferon-gamma production namespace: biological_process -def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] +alt_id: GO:0042095 +alt_id: GO:0072643 +def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] synonym: "IFNG production" EXACT [GOC:mah] +synonym: "interferon-gamma biosynthetic process" NARROW [] +synonym: "interferon-gamma secretion" NARROW [] synonym: "type II IFN production" BROAD [GOC:mah] synonym: "type II interferon production" BROAD [] is_a: GO:0001816 ! cytokine production @@ -186393,232 +186585,378 @@ is_a: GO:0001816 ! cytokine production id: GO:0032610 name: interleukin-1 alpha production namespace: biological_process +alt_id: GO:0050703 +alt_id: GO:0050719 def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 alpha production" EXACT [] +synonym: "interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "interleukin-1 alpha secretion" NARROW [] is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032611 name: interleukin-1 beta production namespace: biological_process +alt_id: GO:0050702 +alt_id: GO:0050720 def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 beta production" EXACT [] +synonym: "interleukin-1 beta biosynthetic process" NARROW [] +synonym: "interleukin-1 beta secretion" NARROW [] is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032612 name: interleukin-1 production namespace: biological_process +alt_id: GO:0042222 +alt_id: GO:0050701 def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 production" EXACT [] +synonym: "interleukin-1 biosynthetic process" NARROW [] +synonym: "interleukin-1 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032613 name: interleukin-10 production namespace: biological_process +alt_id: GO:0042091 +alt_id: GO:0072608 def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-10 production" EXACT [] +synonym: "interleukin-10 biosynthetic process" NARROW [] +synonym: "interleukin-10 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032614 name: interleukin-11 production namespace: biological_process +alt_id: GO:0042230 +alt_id: GO:0072609 def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-11 production" EXACT [] +synonym: "interleukin-11 biosynthetic process" NARROW [] +synonym: "interleukin-11 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032615 name: interleukin-12 production namespace: biological_process +alt_id: GO:0042090 +alt_id: GO:0072610 def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "CLMF production" NARROW [GOC:BHF] synonym: "IL-12 production" EXACT [] +synonym: "interleukin-12 biosynthetic process" NARROW [] +synonym: "interleukin-12 secretion" NARROW [] +synonym: "NKSF production" NARROW [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032616 name: interleukin-13 production namespace: biological_process +alt_id: GO:0042231 +alt_id: GO:0072611 def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-13 production" EXACT [] +synonym: "interleukin-13 biosynthetic process" NARROW [] +synonym: "interleukin-13 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032617 name: interleukin-14 production namespace: biological_process +alt_id: GO:0042232 +alt_id: GO:0072612 def: "The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-14 production" EXACT [] +synonym: "interleukin-14 biosynthetic process" NARROW [] +synonym: "interleukin-14 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032618 name: interleukin-15 production namespace: biological_process +alt_id: GO:0042233 +alt_id: GO:0072613 def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-15 production" EXACT [] +synonym: "interleukin-15 biosynthetic process" NARROW [] +synonym: "interleukin-15 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032619 name: interleukin-16 production namespace: biological_process +alt_id: GO:0042234 +alt_id: GO:0072614 def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-16 production" EXACT [] +synonym: "interleukin-16 biosynthetic process" NARROW [] +synonym: "interleukin-16 secretion" NARROW [] +synonym: "LCF production" NARROW [GOC:BHF] +synonym: "pro-interleukin-16 production" EXACT [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032620 name: interleukin-17 production namespace: biological_process -def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, PR:000001092, Wikipedia:Interleukin_17] +alt_id: GO:0042235 +alt_id: GO:0072615 +def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, Wikipedia:Interleukin_17] +synonym: "CTLA-8 production" EXACT [GOC:BHF] +synonym: "Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:BHF] synonym: "IL-17 production" EXACT [] +synonym: "interleukin-17 biosynthetic process" NARROW [] +synonym: "interleukin-17 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032621 name: interleukin-18 production namespace: biological_process +alt_id: GO:0042241 +alt_id: GO:0072616 def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IGIF production" EXACT [GOC:BHF] synonym: "IL-18 production" EXACT [] +synonym: "IL1F4 production" NARROW [GOC:BHF] +synonym: "interleukin-18 biosynthetic process" NARROW [] +synonym: "interleukin-18 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032622 name: interleukin-19 production namespace: biological_process +alt_id: GO:0042236 +alt_id: GO:0072617 def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-19 production" EXACT [] +synonym: "IL-19 secretion" NARROW [GOC:BHF] +synonym: "interleukin-19 biosynthetic process" NARROW [] +synonym: "interleukin-19 secretion" NARROW [] +synonym: "ZMDA1 secretion" NARROW [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032623 name: interleukin-2 production namespace: biological_process +alt_id: GO:0042094 +alt_id: GO:0070970 def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-2 production" EXACT [] +synonym: "interleukin-2 biosynthetic process" NARROW [] +synonym: "interleukin-2 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032624 name: interleukin-20 production namespace: biological_process +alt_id: GO:0042237 +alt_id: GO:0072618 def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-20 production" EXACT [] +synonym: "interleukin-20 biosynthetic process" NARROW [] +synonym: "interleukin-20 secretion" NARROW [] +synonym: "ZCYTO10 production" EXACT [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032625 name: interleukin-21 production namespace: biological_process +alt_id: GO:0042238 +alt_id: GO:0072619 def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-21 production" EXACT [] +synonym: "interleukin-21 biosynthetic process" NARROW [] +synonym: "interleukin-21 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032626 name: interleukin-22 production namespace: biological_process +alt_id: GO:0042239 +alt_id: GO:0072620 def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-22 production" EXACT [] +synonym: "IL22 production" EXACT [GOC:BHF] +synonym: "ILTIF production" EXACT [GOC:BHF] +synonym: "interleukin-22 biosynthetic process" NARROW [] +synonym: "interleukin-22 secretion" NARROW [] +synonym: "ZCYTO18 production" NARROW [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032627 name: interleukin-23 production namespace: biological_process +alt_id: GO:0042240 +alt_id: GO:0072621 def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-23 production" EXACT [] +synonym: "interleukin-23 biosynthetic process" NARROW [] +synonym: "interleukin-23 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032628 name: interleukin-24 production namespace: biological_process +alt_id: GO:0045524 +alt_id: GO:0072622 def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-24 production" EXACT [] +synonym: "interleukin-24 biosynthetic process" NARROW [] +synonym: "interleukin-24 secretion" NARROW [] +synonym: "MDA7 production" NARROW [GOC:BHF] +synonym: "ST16 production" NARROW [GOC:BHF] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032629 name: interleukin-25 production namespace: biological_process +alt_id: GO:0045525 +alt_id: GO:0072623 def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-25 production" EXACT [] +synonym: "IL-25 secretion" NARROW [GOC:BHF] +synonym: "IL17E secretion" NARROW [GOC:BHF] +synonym: "interleukin-25 anabolism" NARROW [] +synonym: "interleukin-25 biosynthesis" NARROW [] +synonym: "interleukin-25 biosynthetic process" NARROW [] +synonym: "interleukin-25 formation" NARROW [] +synonym: "interleukin-25 secretion" NARROW [] +synonym: "interleukin-25 synthesis" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032630 name: interleukin-26 production namespace: biological_process +alt_id: GO:0045526 +alt_id: GO:0072624 def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "AK155 secretion" NARROW [GOC:BHF] synonym: "IL-26 production" EXACT [] +synonym: "interleukin-26 anabolism" NARROW [] +synonym: "interleukin-26 biosynthesis" NARROW [] +synonym: "interleukin-26 biosynthetic process" NARROW [] +synonym: "interleukin-26 formation" NARROW [] +synonym: "interleukin-26 secretion" NARROW [] +synonym: "interleukin-26 synthesis" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032631 name: interleukin-27 production namespace: biological_process +alt_id: GO:0045527 +alt_id: GO:0072625 def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-27 production" EXACT [] +synonym: "interleukin-27 biosynthetic process" NARROW [] +synonym: "interleukin-27 formation" NARROW [] +synonym: "interleukin-27 secretion" NARROW [] +synonym: "interleukin-27 synthesis" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032632 name: interleukin-3 production namespace: biological_process +alt_id: GO:0042223 +alt_id: GO:0072601 def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-3 production" EXACT [] +synonym: "interleukin-3 biosynthetic process" NARROW [] +synonym: "interleukin-3 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032633 name: interleukin-4 production namespace: biological_process +alt_id: GO:0042097 +alt_id: GO:0042224 +alt_id: GO:0072602 def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-4 production" EXACT [] +synonym: "interleukin-4 biosynthetic process" NARROW [] +synonym: "interleukin-4 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032634 name: interleukin-5 production namespace: biological_process +alt_id: GO:0042225 +alt_id: GO:0072603 def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-5 production" EXACT [] +synonym: "interleukin-5 biosynthetic process" NARROW [] +synonym: "interleukin-5 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032635 name: interleukin-6 production namespace: biological_process +alt_id: GO:0042226 +alt_id: GO:0072604 def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-6 production" EXACT [] +synonym: "interleukin-6 biosynthetic process" NARROW [] +synonym: "interleukin-6 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032636 name: interleukin-7 production namespace: biological_process +alt_id: GO:0042227 +alt_id: GO:0072605 def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-7 production" EXACT [] +synonym: "interleukin-7 biosynthetic process" NARROW [] +synonym: "interleukin-7 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032637 name: interleukin-8 production namespace: biological_process +alt_id: GO:0042228 +alt_id: GO:0072606 def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-8 production" EXACT [] +synonym: "interleukin-8 biosynthetic process" NARROW [] +synonym: "interleukin-8 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032638 name: interleukin-9 production namespace: biological_process +alt_id: GO:0042229 +alt_id: GO:0072607 def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-9 production" EXACT [] +synonym: "interleukin-9 biosynthetic process" NARROW [] +synonym: "interleukin-9 secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] @@ -186664,8 +187002,10 @@ relationship: regulates GO:0032602 ! chemokine production id: GO:0032643 name: regulation of connective tissue growth factor production namespace: biological_process +alt_id: GO:0045420 def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "regulation of CCN2 production" EXACT [] +synonym: "regulation of connective tissue growth factor biosynthetic process" NARROW [] synonym: "regulation of CTGF production" EXACT [] synonym: "regulation of Fisp12 production" EXACT [] synonym: "regulation of Hcs24 production" EXACT [] @@ -186680,11 +187020,16 @@ relationship: regulates GO:0032601 ! connective tissue growth factor production id: GO:0032644 name: regulation of fractalkine production namespace: biological_process +alt_id: GO:0050752 def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah] +synonym: "regulation of CX3CL1 biosynthesis" NARROW [] +synonym: "regulation of CX3CL1 production" NARROW [] +synonym: "regulation of fractalkine biosynthetic process" NARROW [] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032603 ! fractalkine production relationship: regulates GO:0032603 ! fractalkine production +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19254 xsd:anyURI [Term] id: GO:0032645 @@ -186712,7 +187057,11 @@ relationship: regulates GO:0032605 ! hepatocyte growth factor production id: GO:0032647 name: regulation of interferon-alpha production namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah] +alt_id: GO:0045354 +alt_id: GO:1902739 +def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383] +synonym: "regulation of interferon-alpha biosynthetic process" NARROW [] +synonym: "regulation of interferon-alpha secretion" NARROW [] is_a: GO:0032479 ! regulation of type I interferon production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032607 ! interferon-alpha production @@ -186722,8 +187071,12 @@ relationship: regulates GO:0032607 ! interferon-alpha production id: GO:0032648 name: regulation of interferon-beta production namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah] +alt_id: GO:0035547 +alt_id: GO:0045357 +def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383] synonym: "regulation of IFN-beta production" EXACT [] +synonym: "regulation of interferon-beta biosynthetic process" NARROW [] +synonym: "regulation of interferon-beta secretion" NARROW [] is_a: GO:0032479 ! regulation of type I interferon production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032608 ! interferon-beta production @@ -186733,7 +187086,11 @@ relationship: regulates GO:0032608 ! interferon-beta production id: GO:0032649 name: regulation of interferon-gamma production namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] +alt_id: GO:0045072 +alt_id: GO:1902713 +def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] +synonym: "regulation of interferon-gamma biosynthetic process" NARROW [] +synonym: "regulation of interferon-gamma secretion" NARROW [] synonym: "regulation of type II interferon production" BROAD [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process @@ -186744,8 +187101,12 @@ relationship: regulates GO:0032609 ! interferon-gamma production id: GO:0032650 name: regulation of interleukin-1 alpha production namespace: biological_process +alt_id: GO:0050705 +alt_id: GO:0050721 def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "regulation of IL-1 alpha production" EXACT [] +synonym: "regulation of interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "regulation of interleukin-1 alpha secretion" NARROW [] is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032610 ! interleukin-1 alpha production @@ -186755,8 +187116,12 @@ relationship: regulates GO:0032610 ! interleukin-1 alpha production id: GO:0032651 name: regulation of interleukin-1 beta production namespace: biological_process +alt_id: GO:0050706 +alt_id: GO:0050722 def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "regulation of IL-1 beta production" EXACT [] +synonym: "regulation of interleukin-1 beta biosynthetic process" NARROW [] +synonym: "regulation of interleukin-1 beta secretion" NARROW [] is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032611 ! interleukin-1 beta production @@ -186766,8 +187131,12 @@ relationship: regulates GO:0032611 ! interleukin-1 beta production id: GO:0032652 name: regulation of interleukin-1 production namespace: biological_process +alt_id: GO:0045360 +alt_id: GO:0050704 def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "regulation of IL-1 production" EXACT [] +synonym: "regulation of interleukin-1 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-1 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032612 ! interleukin-1 production @@ -186777,8 +187146,12 @@ relationship: regulates GO:0032612 ! interleukin-1 production id: GO:0032653 name: regulation of interleukin-10 production namespace: biological_process +alt_id: GO:0045074 +alt_id: GO:2001179 def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "regulation of IL-10 production" EXACT [] +synonym: "regulation of interleukin-10 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-10 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032613 ! interleukin-10 production @@ -186788,8 +187161,12 @@ relationship: regulates GO:0032613 ! interleukin-10 production id: GO:0032654 name: regulation of interleukin-11 production namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah] +alt_id: GO:0045363 +alt_id: GO:0150169 +def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah, PMID:29286137] synonym: "regulation of IL-11 production" EXACT [] +synonym: "regulation of interleukin-11 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-11 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032614 ! interleukin-11 production @@ -186799,8 +187176,14 @@ relationship: regulates GO:0032614 ! interleukin-11 production id: GO:0032655 name: regulation of interleukin-12 production namespace: biological_process +alt_id: GO:0045075 +alt_id: GO:2001182 def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah] +synonym: "regulation of CLMF production" RELATED [GOC:obol] synonym: "regulation of IL-12 production" EXACT [] +synonym: "regulation of interleukin-12 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-12 secretion" NARROW [] +synonym: "regulation of NKSF production" RELATED [GOC:obol] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032615 ! interleukin-12 production @@ -186810,8 +187193,12 @@ relationship: regulates GO:0032615 ! interleukin-12 production id: GO:0032656 name: regulation of interleukin-13 production namespace: biological_process +alt_id: GO:0045366 +alt_id: GO:2000665 def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "regulation of IL-13 production" EXACT [] +synonym: "regulation of interleukin-13 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-13 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032616 ! interleukin-13 production @@ -186821,8 +187208,10 @@ relationship: regulates GO:0032616 ! interleukin-13 production id: GO:0032657 name: regulation of interleukin-14 production namespace: biological_process +alt_id: GO:0045369 def: "Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "regulation of IL-14 production" EXACT [] +synonym: "regulation of interleukin-14 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032617 ! interleukin-14 production @@ -186832,8 +187221,10 @@ relationship: regulates GO:0032617 ! interleukin-14 production id: GO:0032658 name: regulation of interleukin-15 production namespace: biological_process +alt_id: GO:0045372 def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "regulation of IL-15 production" EXACT [] +synonym: "regulation of interleukin-15 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032618 ! interleukin-15 production @@ -186843,8 +187234,10 @@ relationship: regulates GO:0032618 ! interleukin-15 production id: GO:0032659 name: regulation of interleukin-16 production namespace: biological_process +alt_id: GO:0045375 def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "regulation of IL-16 production" EXACT [] +synonym: "regulation of interleukin-16 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032619 ! interleukin-16 production @@ -186854,8 +187247,14 @@ relationship: regulates GO:0032619 ! interleukin-16 production id: GO:0032660 name: regulation of interleukin-17 production namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah] +alt_id: GO:0045378 +alt_id: GO:1905076 +def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511] +synonym: "regulation of CTLA-8 production" EXACT [GOC:TermGenie] +synonym: "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [] synonym: "regulation of IL-17 production" EXACT [] +synonym: "regulation of interleukin-17 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-17 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032620 ! interleukin-17 production @@ -186865,8 +187264,12 @@ relationship: regulates GO:0032620 ! interleukin-17 production id: GO:0032661 name: regulation of interleukin-18 production namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah] +alt_id: GO:0045381 +alt_id: GO:0150120 +def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah, PMID:23710316] synonym: "regulation of IL-18 production" EXACT [] +synonym: "regulation of interleukin-18 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-18 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032621 ! interleukin-18 production @@ -186876,8 +187279,10 @@ relationship: regulates GO:0032621 ! interleukin-18 production id: GO:0032662 name: regulation of interleukin-19 production namespace: biological_process +alt_id: GO:0045384 def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "regulation of IL-19 production" EXACT [] +synonym: "regulation of interleukin-19 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032622 ! interleukin-19 production @@ -186887,8 +187292,12 @@ relationship: regulates GO:0032622 ! interleukin-19 production id: GO:0032663 name: regulation of interleukin-2 production namespace: biological_process +alt_id: GO:0045076 +alt_id: GO:1900040 def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "regulation of IL-2 production" EXACT [] +synonym: "regulation of interleukin-2 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-2 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032623 ! interleukin-2 production @@ -186898,8 +187307,10 @@ relationship: regulates GO:0032623 ! interleukin-2 production id: GO:0032664 name: regulation of interleukin-20 production namespace: biological_process +alt_id: GO:0045387 def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "regulation of IL-20 production" EXACT [] +synonym: "regulation of interleukin-20 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032624 ! interleukin-20 production @@ -186909,8 +187320,10 @@ relationship: regulates GO:0032624 ! interleukin-20 production id: GO:0032665 name: regulation of interleukin-21 production namespace: biological_process +alt_id: GO:0045390 def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "regulation of IL-21 production" EXACT [] +synonym: "regulation of interleukin-21 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032625 ! interleukin-21 production @@ -186920,8 +187333,10 @@ relationship: regulates GO:0032625 ! interleukin-21 production id: GO:0032666 name: regulation of interleukin-22 production namespace: biological_process +alt_id: GO:0045393 def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "regulation of IL-22 production" EXACT [] +synonym: "regulation of interleukin-22 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032626 ! interleukin-22 production @@ -186931,8 +187346,15 @@ relationship: regulates GO:0032626 ! interleukin-22 production id: GO:0032667 name: regulation of interleukin-23 production namespace: biological_process +alt_id: GO:0045396 def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah] +synonym: "regulation of IL-23 biosynthetic process" EXACT [] synonym: "regulation of IL-23 production" EXACT [] +synonym: "regulation of interleukin-23 anabolism" NARROW [] +synonym: "regulation of interleukin-23 biosynthesis" NARROW [] +synonym: "regulation of interleukin-23 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-23 formation" NARROW [] +synonym: "regulation of interleukin-23 synthesis" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032627 ! interleukin-23 production @@ -186942,8 +187364,10 @@ relationship: regulates GO:0032627 ! interleukin-23 production id: GO:0032668 name: regulation of interleukin-24 production namespace: biological_process +alt_id: GO:0045528 def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "regulation of IL-24 production" EXACT [] +synonym: "regulation of interleukin-24 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032628 ! interleukin-24 production @@ -186953,19 +187377,27 @@ relationship: regulates GO:0032628 ! interleukin-24 production id: GO:0032669 name: regulation of interleukin-25 production namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah] +alt_id: GO:0045529 +alt_id: GO:0150148 +def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah, PMID:27901018] synonym: "regulation of IL-25 production" EXACT [] +synonym: "regulation of interleukin-25 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-25 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032629 ! interleukin-25 production relationship: regulates GO:0032629 ! interleukin-25 production +created_by: bc +creation_date: 2019-12-09T16:51:07Z [Term] id: GO:0032670 name: regulation of interleukin-26 production namespace: biological_process +alt_id: GO:0045530 def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "regulation of IL-26 production" EXACT [] +synonym: "regulation of interleukin-26 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032630 ! interleukin-26 production @@ -186975,8 +187407,12 @@ relationship: regulates GO:0032630 ! interleukin-26 production id: GO:0032671 name: regulation of interleukin-27 production namespace: biological_process +alt_id: GO:0045531 def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "regulation of IL-27 production" EXACT [] +synonym: "regulation of interleukin-27 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-27 formation" NARROW [] +synonym: "regulation of interleukin-27 synthesis" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032631 ! interleukin-27 production @@ -186986,8 +187422,10 @@ relationship: regulates GO:0032631 ! interleukin-27 production id: GO:0032672 name: regulation of interleukin-3 production namespace: biological_process +alt_id: GO:0045399 def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "regulation of IL-3 production" EXACT [] +synonym: "regulation of interleukin-3 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032632 ! interleukin-3 production @@ -186997,8 +187435,12 @@ relationship: regulates GO:0032632 ! interleukin-3 production id: GO:0032673 name: regulation of interleukin-4 production namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah] +alt_id: GO:0045402 +alt_id: GO:0150133 +def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524] synonym: "regulation of IL-4 production" EXACT [] +synonym: "regulation of interleukin-4 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-4 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032633 ! interleukin-4 production @@ -187008,8 +187450,12 @@ relationship: regulates GO:0032633 ! interleukin-4 production id: GO:0032674 name: regulation of interleukin-5 production namespace: biological_process +alt_id: GO:0045405 +alt_id: GO:2000662 def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "regulation of IL-5 production" EXACT [] +synonym: "regulation of interleukin-5 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-5 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032634 ! interleukin-5 production @@ -187019,8 +187465,10 @@ relationship: regulates GO:0032634 ! interleukin-5 production id: GO:0032675 name: regulation of interleukin-6 production namespace: biological_process +alt_id: GO:0045408 def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "regulation of IL-6 production" EXACT [] +synonym: "regulation of interleukin-6 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032635 ! interleukin-6 production @@ -187030,8 +187478,12 @@ relationship: regulates GO:0032635 ! interleukin-6 production id: GO:0032676 name: regulation of interleukin-7 production namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah] +alt_id: GO:0045411 +alt_id: GO:0150112 +def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah, PMID:25962782] synonym: "regulation of IL-7 production" EXACT [] +synonym: "regulation of interleukin-7 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-7 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032636 ! interleukin-7 production @@ -187041,8 +187493,12 @@ relationship: regulates GO:0032636 ! interleukin-7 production id: GO:0032677 name: regulation of interleukin-8 production namespace: biological_process +alt_id: GO:0045414 +alt_id: GO:2000482 def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "regulation of IL-8 production" EXACT [] +synonym: "regulation of interleukin-8 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-8 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032637 ! interleukin-8 production @@ -187052,8 +187508,10 @@ relationship: regulates GO:0032637 ! interleukin-8 production id: GO:0032678 name: regulation of interleukin-9 production namespace: biological_process +alt_id: GO:0045417 def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "regulation of IL-9 production" EXACT [] +synonym: "regulation of interleukin-9 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0032638 ! interleukin-9 production @@ -187116,12 +187574,14 @@ relationship: negatively_regulates GO:0032602 ! chemokine production id: GO:0032683 name: negative regulation of connective tissue growth factor production namespace: biological_process +alt_id: GO:0045421 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "down regulation of connective tissue growth factor production" EXACT [] synonym: "down-regulation of connective tissue growth factor production" EXACT [] synonym: "downregulation of connective tissue growth factor production" EXACT [] synonym: "inhibition of connective tissue growth factor production" NARROW [] synonym: "negative regulation of CCN2 production" EXACT [] +synonym: "negative regulation of connective tissue growth factor biosynthetic process" NARROW [] synonym: "negative regulation of CTGF production" EXACT [] synonym: "negative regulation of Fisp12 production" EXACT [] synonym: "negative regulation of Hcs24 production" EXACT [] @@ -187137,16 +187597,21 @@ relationship: negatively_regulates GO:0032601 ! connective tissue growth factor id: GO:0032684 name: negative regulation of fractalkine production namespace: biological_process +alt_id: GO:0050753 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah] synonym: "down regulation of fractalkine production" EXACT [] synonym: "down-regulation of fractalkine production" EXACT [] synonym: "downregulation of fractalkine production" EXACT [] synonym: "inhibition of fractalkine production" NARROW [] +synonym: "negative regulation of CX3CL1 biosynthesis" NARROW [] +synonym: "negative regulation of CX3CL1 production" EXACT [] +synonym: "negative regulation of fractalkine biosynthetic process" NARROW [] is_a: GO:0032644 ! regulation of fractalkine production is_a: GO:0032682 ! negative regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0032603 ! fractalkine production relationship: negatively_regulates GO:0032603 ! fractalkine production +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19254 xsd:anyURI [Term] id: GO:0032685 @@ -187184,11 +187649,15 @@ relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor product id: GO:0032687 name: negative regulation of interferon-alpha production namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah] +alt_id: GO:0045355 +alt_id: GO:1902740 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383] synonym: "down regulation of interferon-alpha production" EXACT [] synonym: "down-regulation of interferon-alpha production" EXACT [] synonym: "downregulation of interferon-alpha production" EXACT [] synonym: "inhibition of interferon-alpha production" NARROW [] +synonym: "negative regulation of interferon-alpha biosynthetic process" NARROW [] +synonym: "negative regulation of interferon-alpha secretion" NARROW [] is_a: GO:0032480 ! negative regulation of type I interferon production is_a: GO:0032647 ! regulation of interferon-alpha production intersection_of: GO:0008150 ! biological_process @@ -187199,12 +187668,16 @@ relationship: negatively_regulates GO:0032607 ! interferon-alpha production id: GO:0032688 name: negative regulation of interferon-beta production namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah] +alt_id: GO:0035548 +alt_id: GO:0045358 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383] synonym: "down regulation of interferon-beta production" EXACT [] synonym: "down-regulation of interferon-beta production" EXACT [] synonym: "downregulation of interferon-beta production" EXACT [] synonym: "inhibition of interferon-beta production" NARROW [] synonym: "negative regulation of IFN-beta production" EXACT [] +synonym: "negative regulation of interferon-beta biosynthetic process" NARROW [] +synonym: "negative regulation of interferon-beta secretion" NARROW [] is_a: GO:0032480 ! negative regulation of type I interferon production is_a: GO:0032648 ! regulation of interferon-beta production intersection_of: GO:0008150 ! biological_process @@ -187215,11 +187688,15 @@ relationship: negatively_regulates GO:0032608 ! interferon-beta production id: GO:0032689 name: negative regulation of interferon-gamma production namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] +alt_id: GO:0045077 +alt_id: GO:1902714 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] synonym: "down regulation of interferon-gamma production" EXACT [] synonym: "down-regulation of interferon-gamma production" EXACT [] synonym: "downregulation of interferon-gamma production" EXACT [] synonym: "inhibition of interferon-gamma production" NARROW [] +synonym: "negative regulation of interferon-gamma biosynthetic process" NARROW [] +synonym: "negative regulation of interferon-gamma secretion" NARROW [] synonym: "negative regulation of type II interferon production" BROAD [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032649 ! regulation of interferon-gamma production @@ -187231,12 +187708,16 @@ relationship: negatively_regulates GO:0032609 ! interferon-gamma production id: GO:0032690 name: negative regulation of interleukin-1 alpha production namespace: biological_process +alt_id: GO:0050712 +alt_id: GO:0050723 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "down regulation of interleukin-1 alpha production" EXACT [] synonym: "down-regulation of interleukin-1 alpha production" EXACT [] synonym: "downregulation of interleukin-1 alpha production" EXACT [] synonym: "inhibition of interleukin-1 alpha production" NARROW [] synonym: "negative regulation of IL-1 alpha production" EXACT [] +synonym: "negative regulation of interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-1 alpha secretion" NARROW [] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0032692 ! negative regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process @@ -187247,12 +187728,16 @@ relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production id: GO:0032691 name: negative regulation of interleukin-1 beta production namespace: biological_process +alt_id: GO:0050713 +alt_id: GO:0050724 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "down regulation of interleukin-1 beta production" EXACT [] synonym: "down-regulation of interleukin-1 beta production" EXACT [] synonym: "downregulation of interleukin-1 beta production" EXACT [] synonym: "inhibition of interleukin-1 beta production" NARROW [] synonym: "negative regulation of IL-1 beta production" EXACT [] +synonym: "negative regulation of interleukin-1 beta biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-1 beta secretion" NARROW [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0032692 ! negative regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process @@ -187263,12 +187748,16 @@ relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production id: GO:0032692 name: negative regulation of interleukin-1 production namespace: biological_process +alt_id: GO:0045361 +alt_id: GO:0050711 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "down regulation of interleukin-1 production" EXACT [] synonym: "down-regulation of interleukin-1 production" EXACT [] synonym: "downregulation of interleukin-1 production" EXACT [] synonym: "inhibition of interleukin-1 production" NARROW [] synonym: "negative regulation of IL-1 production" EXACT [] +synonym: "negative regulation of interleukin-1 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-1 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032652 ! regulation of interleukin-1 production intersection_of: GO:0008150 ! biological_process @@ -187279,12 +187768,16 @@ relationship: negatively_regulates GO:0032612 ! interleukin-1 production id: GO:0032693 name: negative regulation of interleukin-10 production namespace: biological_process +alt_id: GO:0045081 +alt_id: GO:2001180 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "down regulation of interleukin-10 production" EXACT [] synonym: "down-regulation of interleukin-10 production" EXACT [] synonym: "downregulation of interleukin-10 production" EXACT [] synonym: "inhibition of interleukin-10 production" NARROW [] synonym: "negative regulation of IL-10 production" EXACT [] +synonym: "negative regulation of interleukin-10 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-10 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032653 ! regulation of interleukin-10 production intersection_of: GO:0008150 ! biological_process @@ -187295,12 +187788,16 @@ relationship: negatively_regulates GO:0032613 ! interleukin-10 production id: GO:0032694 name: negative regulation of interleukin-11 production namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah] +alt_id: GO:0045364 +alt_id: GO:0150170 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah, PMID:29286137] synonym: "down regulation of interleukin-11 production" EXACT [] synonym: "down-regulation of interleukin-11 production" EXACT [] synonym: "downregulation of interleukin-11 production" EXACT [] synonym: "inhibition of interleukin-11 production" NARROW [] synonym: "negative regulation of IL-11 production" EXACT [] +synonym: "negative regulation of interleukin-11 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-11 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032654 ! regulation of interleukin-11 production intersection_of: GO:0008150 ! biological_process @@ -187311,12 +187808,18 @@ relationship: negatively_regulates GO:0032614 ! interleukin-11 production id: GO:0032695 name: negative regulation of interleukin-12 production namespace: biological_process +alt_id: GO:0045083 +alt_id: GO:2001183 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "down regulation of interleukin-12 production" EXACT [] synonym: "down-regulation of interleukin-12 production" EXACT [] synonym: "downregulation of interleukin-12 production" EXACT [] synonym: "inhibition of interleukin-12 production" NARROW [] +synonym: "negative regulation of CLMF production" RELATED [GOC:obol] synonym: "negative regulation of IL-12 production" EXACT [] +synonym: "negative regulation of interleukin-12 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-12 secretion" NARROW [] +synonym: "negative regulation of NKSF production" RELATED [GOC:obol] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032655 ! regulation of interleukin-12 production intersection_of: GO:0008150 ! biological_process @@ -187327,12 +187830,16 @@ relationship: negatively_regulates GO:0032615 ! interleukin-12 production id: GO:0032696 name: negative regulation of interleukin-13 production namespace: biological_process +alt_id: GO:0045367 +alt_id: GO:2000666 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "down regulation of interleukin-13 production" EXACT [] synonym: "down-regulation of interleukin-13 production" EXACT [] synonym: "downregulation of interleukin-13 production" EXACT [] synonym: "inhibition of interleukin-13 production" NARROW [] synonym: "negative regulation of IL-13 production" EXACT [] +synonym: "negative regulation of interleukin-13 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-13 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032656 ! regulation of interleukin-13 production intersection_of: GO:0008150 ! biological_process @@ -187343,12 +187850,14 @@ relationship: negatively_regulates GO:0032616 ! interleukin-13 production id: GO:0032697 name: negative regulation of interleukin-14 production namespace: biological_process +alt_id: GO:0045370 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "down regulation of interleukin-14 production" EXACT [] synonym: "down-regulation of interleukin-14 production" EXACT [] synonym: "downregulation of interleukin-14 production" EXACT [] synonym: "inhibition of interleukin-14 production" NARROW [] synonym: "negative regulation of IL-14 production" EXACT [] +synonym: "negative regulation of interleukin-14 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032657 ! regulation of interleukin-14 production intersection_of: GO:0008150 ! biological_process @@ -187359,12 +187868,14 @@ relationship: negatively_regulates GO:0032617 ! interleukin-14 production id: GO:0032698 name: negative regulation of interleukin-15 production namespace: biological_process +alt_id: GO:0045373 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "down regulation of interleukin-15 production" EXACT [] synonym: "down-regulation of interleukin-15 production" EXACT [] synonym: "downregulation of interleukin-15 production" EXACT [] synonym: "inhibition of interleukin-15 production" NARROW [] synonym: "negative regulation of IL-15 production" EXACT [] +synonym: "negative regulation of interleukin-15 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032658 ! regulation of interleukin-15 production intersection_of: GO:0008150 ! biological_process @@ -187375,12 +187886,14 @@ relationship: negatively_regulates GO:0032618 ! interleukin-15 production id: GO:0032699 name: negative regulation of interleukin-16 production namespace: biological_process +alt_id: GO:0045376 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "down regulation of interleukin-16 production" EXACT [] synonym: "down-regulation of interleukin-16 production" EXACT [] synonym: "downregulation of interleukin-16 production" EXACT [] synonym: "inhibition of interleukin-16 production" NARROW [] synonym: "negative regulation of IL-16 production" EXACT [] +synonym: "negative regulation of interleukin-16 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032659 ! regulation of interleukin-16 production intersection_of: GO:0008150 ! biological_process @@ -187391,12 +187904,17 @@ relationship: negatively_regulates GO:0032619 ! interleukin-16 production id: GO:0032700 name: negative regulation of interleukin-17 production namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah] +alt_id: GO:0045379 +alt_id: GO:1905077 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511] synonym: "down regulation of interleukin-17 production" EXACT [] -synonym: "down-regulation of interleukin-17 production" EXACT [] synonym: "downregulation of interleukin-17 production" EXACT [] synonym: "inhibition of interleukin-17 production" NARROW [] +synonym: "negative regulation of CTLA-8 production" NARROW [GOC:TermGenie] +synonym: "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] synonym: "negative regulation of IL-17 production" EXACT [] +synonym: "negative regulation of interleukin-17 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-17 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032660 ! regulation of interleukin-17 production intersection_of: GO:0008150 ! biological_process @@ -187407,12 +187925,16 @@ relationship: negatively_regulates GO:0032620 ! interleukin-17 production id: GO:0032701 name: negative regulation of interleukin-18 production namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah] +alt_id: GO:0045382 +alt_id: GO:0150121 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah, PMID:23710316] synonym: "down regulation of interleukin-18 production" EXACT [] synonym: "down-regulation of interleukin-18 production" EXACT [] synonym: "downregulation of interleukin-18 production" EXACT [] synonym: "inhibition of interleukin-18 production" NARROW [] synonym: "negative regulation of IL-18 production" EXACT [] +synonym: "negative regulation of interleukin-18 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-18 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032661 ! regulation of interleukin-18 production intersection_of: GO:0008150 ! biological_process @@ -187423,12 +187945,14 @@ relationship: negatively_regulates GO:0032621 ! interleukin-18 production id: GO:0032702 name: negative regulation of interleukin-19 production namespace: biological_process +alt_id: GO:0045385 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "down regulation of interleukin-19 production" EXACT [] synonym: "down-regulation of interleukin-19 production" EXACT [] synonym: "downregulation of interleukin-19 production" EXACT [] synonym: "inhibition of interleukin-19 production" NARROW [] synonym: "negative regulation of IL-19 production" EXACT [] +synonym: "negative regulation of interleukin-19 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032662 ! regulation of interleukin-19 production intersection_of: GO:0008150 ! biological_process @@ -187439,12 +187963,16 @@ relationship: negatively_regulates GO:0032622 ! interleukin-19 production id: GO:0032703 name: negative regulation of interleukin-2 production namespace: biological_process +alt_id: GO:0045085 +alt_id: GO:1900041 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "down regulation of interleukin-2 production" EXACT [] synonym: "down-regulation of interleukin-2 production" EXACT [] synonym: "downregulation of interleukin-2 production" EXACT [] synonym: "inhibition of interleukin-2 production" NARROW [] synonym: "negative regulation of IL-2 production" EXACT [] +synonym: "negative regulation of interleukin-2 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-2 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032663 ! regulation of interleukin-2 production intersection_of: GO:0008150 ! biological_process @@ -187455,12 +187983,14 @@ relationship: negatively_regulates GO:0032623 ! interleukin-2 production id: GO:0032704 name: negative regulation of interleukin-20 production namespace: biological_process +alt_id: GO:0045388 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "down regulation of interleukin-20 production" EXACT [] synonym: "down-regulation of interleukin-20 production" EXACT [] synonym: "downregulation of interleukin-20 production" EXACT [] synonym: "inhibition of interleukin-20 production" NARROW [] synonym: "negative regulation of IL-20 production" EXACT [] +synonym: "negative regulation of interleukin-20 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032664 ! regulation of interleukin-20 production intersection_of: GO:0008150 ! biological_process @@ -187471,12 +188001,12 @@ relationship: negatively_regulates GO:0032624 ! interleukin-20 production id: GO:0032705 name: negative regulation of interleukin-21 production namespace: biological_process +alt_id: GO:0045391 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "down regulation of interleukin-21 production" EXACT [] synonym: "down-regulation of interleukin-21 production" EXACT [] synonym: "downregulation of interleukin-21 production" EXACT [] -synonym: "inhibition of interleukin-21 production" NARROW [] -synonym: "negative regulation of IL-21 production" EXACT [] +synonym: "negative regulation of interleukin-21 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032665 ! regulation of interleukin-21 production intersection_of: GO:0008150 ! biological_process @@ -187487,12 +188017,14 @@ relationship: negatively_regulates GO:0032625 ! interleukin-21 production id: GO:0032706 name: negative regulation of interleukin-22 production namespace: biological_process +alt_id: GO:0045394 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "down regulation of interleukin-22 production" EXACT [] synonym: "down-regulation of interleukin-22 production" EXACT [] synonym: "downregulation of interleukin-22 production" EXACT [] synonym: "inhibition of interleukin-22 production" NARROW [] synonym: "negative regulation of IL-22 production" EXACT [] +synonym: "negative regulation of interleukin-22 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032666 ! regulation of interleukin-22 production intersection_of: GO:0008150 ! biological_process @@ -187503,12 +188035,14 @@ relationship: negatively_regulates GO:0032626 ! interleukin-22 production id: GO:0032707 name: negative regulation of interleukin-23 production namespace: biological_process +alt_id: GO:0045397 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "down regulation of interleukin-23 production" EXACT [] synonym: "down-regulation of interleukin-23 production" EXACT [] synonym: "downregulation of interleukin-23 production" EXACT [] synonym: "inhibition of interleukin-23 production" NARROW [] synonym: "negative regulation of IL-23 production" EXACT [] +synonym: "negative regulation of interleukin-23 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032667 ! regulation of interleukin-23 production intersection_of: GO:0008150 ! biological_process @@ -187519,12 +188053,14 @@ relationship: negatively_regulates GO:0032627 ! interleukin-23 production id: GO:0032708 name: negative regulation of interleukin-24 production namespace: biological_process +alt_id: GO:0045532 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "down regulation of interleukin-24 production" EXACT [] synonym: "down-regulation of interleukin-24 production" EXACT [] synonym: "downregulation of interleukin-24 production" EXACT [] synonym: "inhibition of interleukin-24 production" NARROW [] synonym: "negative regulation of IL-24 production" EXACT [] +synonym: "negative regulation of interleukin-24 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032668 ! regulation of interleukin-24 production intersection_of: GO:0008150 ! biological_process @@ -187535,12 +188071,16 @@ relationship: negatively_regulates GO:0032628 ! interleukin-24 production id: GO:0032709 name: negative regulation of interleukin-25 production namespace: biological_process +alt_id: GO:0045533 +alt_id: GO:0150149 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "down regulation of interleukin-25 production" EXACT [] synonym: "down-regulation of interleukin-25 production" EXACT [] synonym: "downregulation of interleukin-25 production" EXACT [] synonym: "inhibition of interleukin-25 production" NARROW [] synonym: "negative regulation of IL-25 production" EXACT [] +synonym: "negative regulation of interleukin-25 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-25 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032669 ! regulation of interleukin-25 production intersection_of: GO:0008150 ! biological_process @@ -187551,12 +188091,14 @@ relationship: negatively_regulates GO:0032629 ! interleukin-25 production id: GO:0032710 name: negative regulation of interleukin-26 production namespace: biological_process +alt_id: GO:0045534 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "down regulation of interleukin-26 production" EXACT [] synonym: "down-regulation of interleukin-26 production" EXACT [] synonym: "downregulation of interleukin-26 production" EXACT [] synonym: "inhibition of interleukin-26 production" NARROW [] synonym: "negative regulation of IL-26 production" EXACT [] +synonym: "negative regulation of interleukin-26 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032670 ! regulation of interleukin-26 production intersection_of: GO:0008150 ! biological_process @@ -187567,12 +188109,14 @@ relationship: negatively_regulates GO:0032630 ! interleukin-26 production id: GO:0032711 name: negative regulation of interleukin-27 production namespace: biological_process +alt_id: GO:0045535 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "down regulation of interleukin-27 production" EXACT [] synonym: "down-regulation of interleukin-27 production" EXACT [] synonym: "downregulation of interleukin-27 production" EXACT [] synonym: "inhibition of interleukin-27 production" NARROW [] synonym: "negative regulation of IL-27 production" EXACT [] +synonym: "negative regulation of interleukin-27 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032671 ! regulation of interleukin-27 production intersection_of: GO:0008150 ! biological_process @@ -187583,12 +188127,14 @@ relationship: negatively_regulates GO:0032631 ! interleukin-27 production id: GO:0032712 name: negative regulation of interleukin-3 production namespace: biological_process +alt_id: GO:0045400 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "down regulation of interleukin-3 production" EXACT [] synonym: "down-regulation of interleukin-3 production" EXACT [] synonym: "downregulation of interleukin-3 production" EXACT [] synonym: "inhibition of interleukin-3 production" NARROW [] synonym: "negative regulation of IL-3 production" EXACT [] +synonym: "negative regulation of interleukin-3 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032672 ! regulation of interleukin-3 production intersection_of: GO:0008150 ! biological_process @@ -187599,28 +188145,37 @@ relationship: negatively_regulates GO:0032632 ! interleukin-3 production id: GO:0032713 name: negative regulation of interleukin-4 production namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah] +alt_id: GO:0045403 +alt_id: GO:0150134 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524] synonym: "down regulation of interleukin-4 production" EXACT [] synonym: "down-regulation of interleukin-4 production" EXACT [] synonym: "downregulation of interleukin-4 production" EXACT [] synonym: "inhibition of interleukin-4 production" NARROW [] synonym: "negative regulation of IL-4 production" EXACT [] +synonym: "negative regulation of interleukin-4 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-4 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032673 ! regulation of interleukin-4 production -intersection_of: GO:0008150 ! biological_process +intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032633 ! interleukin-4 production relationship: negatively_regulates GO:0032633 ! interleukin-4 production +created_by: bc [Term] id: GO:0032714 name: negative regulation of interleukin-5 production namespace: biological_process +alt_id: GO:0045406 +alt_id: GO:2000663 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "down regulation of interleukin-5 production" EXACT [] synonym: "down-regulation of interleukin-5 production" EXACT [] synonym: "downregulation of interleukin-5 production" EXACT [] synonym: "inhibition of interleukin-5 production" NARROW [] synonym: "negative regulation of IL-5 production" EXACT [] +synonym: "negative regulation of interleukin-5 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-5 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032674 ! regulation of interleukin-5 production intersection_of: GO:0008150 ! biological_process @@ -187631,12 +188186,16 @@ relationship: negatively_regulates GO:0032634 ! interleukin-5 production id: GO:0032715 name: negative regulation of interleukin-6 production namespace: biological_process +alt_id: GO:0045409 +alt_id: GO:1900165 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "down regulation of interleukin-6 production" EXACT [] synonym: "down-regulation of interleukin-6 production" EXACT [] synonym: "downregulation of interleukin-6 production" EXACT [] synonym: "inhibition of interleukin-6 production" NARROW [] synonym: "negative regulation of IL-6 production" EXACT [] +synonym: "negative regulation of interleukin-6 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-6 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032675 ! regulation of interleukin-6 production intersection_of: GO:0008150 ! biological_process @@ -187647,12 +188206,16 @@ relationship: negatively_regulates GO:0032635 ! interleukin-6 production id: GO:0032716 name: negative regulation of interleukin-7 production namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah] +alt_id: GO:0045412 +alt_id: GO:0150113 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah, PMID:25962782] synonym: "down regulation of interleukin-7 production" EXACT [] synonym: "down-regulation of interleukin-7 production" EXACT [] synonym: "downregulation of interleukin-7 production" EXACT [] synonym: "inhibition of interleukin-7 production" NARROW [] synonym: "negative regulation of IL-7 production" EXACT [] +synonym: "negative regulation of interleukin-7 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-7 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032676 ! regulation of interleukin-7 production intersection_of: GO:0008150 ! biological_process @@ -187663,12 +188226,16 @@ relationship: negatively_regulates GO:0032636 ! interleukin-7 production id: GO:0032717 name: negative regulation of interleukin-8 production namespace: biological_process +alt_id: GO:0045415 +alt_id: GO:2000483 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "down regulation of interleukin-8 production" EXACT [] synonym: "down-regulation of interleukin-8 production" EXACT [] synonym: "downregulation of interleukin-8 production" EXACT [] synonym: "inhibition of interleukin-8 production" NARROW [] synonym: "negative regulation of IL-8 production" EXACT [] +synonym: "negative regulation of interleukin-8 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-8 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032677 ! regulation of interleukin-8 production intersection_of: GO:0008150 ! biological_process @@ -187679,12 +188246,14 @@ relationship: negatively_regulates GO:0032637 ! interleukin-8 production id: GO:0032718 name: negative regulation of interleukin-9 production namespace: biological_process +alt_id: GO:0045418 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "down regulation of interleukin-9 production" EXACT [] synonym: "down-regulation of interleukin-9 production" EXACT [] synonym: "downregulation of interleukin-9 production" EXACT [] synonym: "inhibition of interleukin-9 production" NARROW [] synonym: "negative regulation of IL-9 production" EXACT [] +synonym: "negative regulation of interleukin-9 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032678 ! regulation of interleukin-9 production intersection_of: GO:0008150 ! biological_process @@ -187764,9 +188333,11 @@ relationship: positively_regulates GO:0032602 ! chemokine production id: GO:0032723 name: positive regulation of connective tissue growth factor production namespace: biological_process +alt_id: GO:0045422 def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "activation of connective tissue growth factor production" NARROW [] synonym: "positive regulation of CCN2 production" EXACT [] +synonym: "positive regulation of connective tissue growth factor biosynthetic process" NARROW [] synonym: "positive regulation of CTGF production" EXACT [] synonym: "positive regulation of Fisp12 production" EXACT [] synonym: "positive regulation of Hcs24 production" EXACT [] @@ -187836,8 +188407,12 @@ relationship: positively_regulates GO:0032605 ! hepatocyte growth factor product id: GO:0032727 name: positive regulation of interferon-alpha production namespace: biological_process -def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah] +alt_id: GO:0045356 +alt_id: GO:1902741 +def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383] synonym: "activation of interferon-alpha production" NARROW [] +synonym: "positive regulation of interferon-alpha biosynthetic process" NARROW [] +synonym: "positive regulation of interferon-alpha secretion" NARROW [] synonym: "stimulation of interferon-alpha production" NARROW [] synonym: "up regulation of interferon-alpha production" EXACT [] synonym: "up-regulation of interferon-alpha production" EXACT [] @@ -187852,9 +188427,13 @@ relationship: positively_regulates GO:0032607 ! interferon-alpha production id: GO:0032728 name: positive regulation of interferon-beta production namespace: biological_process -def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah] +alt_id: GO:0035549 +alt_id: GO:0045359 +def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383] synonym: "activation of interferon-beta production" NARROW [] synonym: "positive regulation of IFN-beta production" EXACT [] +synonym: "positive regulation of interferon-beta biosynthetic process" NARROW [] +synonym: "positive regulation of interferon-beta secretion" NARROW [] synonym: "stimulation of interferon-beta production" NARROW [] synonym: "up regulation of interferon-beta production" EXACT [] synonym: "up-regulation of interferon-beta production" EXACT [] @@ -187869,8 +188448,12 @@ relationship: positively_regulates GO:0032608 ! interferon-beta production id: GO:0032729 name: positive regulation of interferon-gamma production namespace: biological_process -def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] +alt_id: GO:0045078 +alt_id: GO:1902715 +def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] synonym: "activation of interferon-gamma production" NARROW [] +synonym: "positive regulation of interferon-gamma biosynthetic process" NARROW [] +synonym: "positive regulation of interferon-gamma secretion" NARROW [] synonym: "positive regulation of type II interferon production" BROAD [] synonym: "stimulation of interferon-gamma production" NARROW [] synonym: "up regulation of interferon-gamma production" EXACT [] @@ -187886,9 +188469,13 @@ relationship: positively_regulates GO:0032609 ! interferon-gamma production id: GO:0032730 name: positive regulation of interleukin-1 alpha production namespace: biological_process +alt_id: GO:0050717 +alt_id: GO:0050726 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "activation of interleukin-1 alpha production" NARROW [] synonym: "positive regulation of IL-1 alpha production" EXACT [] +synonym: "positive regulation of interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-1 alpha secretion" NARROW [] synonym: "stimulation of interleukin-1 alpha production" NARROW [] synonym: "up regulation of interleukin-1 alpha production" EXACT [] synonym: "up-regulation of interleukin-1 alpha production" EXACT [] @@ -187903,9 +188490,13 @@ relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production id: GO:0032731 name: positive regulation of interleukin-1 beta production namespace: biological_process +alt_id: GO:0050718 +alt_id: GO:0050725 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "activation of interleukin-1 beta production" NARROW [] synonym: "positive regulation of IL-1 beta production" EXACT [] +synonym: "positive regulation of interleukin-1 beta biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-1 beta secretion" NARROW [] synonym: "stimulation of interleukin-1 beta production" NARROW [] synonym: "up regulation of interleukin-1 beta production" EXACT [] synonym: "up-regulation of interleukin-1 beta production" EXACT [] @@ -187920,9 +188511,13 @@ relationship: positively_regulates GO:0032611 ! interleukin-1 beta production id: GO:0032732 name: positive regulation of interleukin-1 production namespace: biological_process +alt_id: GO:0045362 +alt_id: GO:0050716 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "activation of interleukin-1 production" NARROW [] synonym: "positive regulation of IL-1 production" EXACT [] +synonym: "positive regulation of interleukin-1 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-1 secretion" NARROW [] synonym: "stimulation of interleukin-1 production" NARROW [] synonym: "up regulation of interleukin-1 production" EXACT [] synonym: "up-regulation of interleukin-1 production" EXACT [] @@ -187937,9 +188532,13 @@ relationship: positively_regulates GO:0032612 ! interleukin-1 production id: GO:0032733 name: positive regulation of interleukin-10 production namespace: biological_process +alt_id: GO:0045082 +alt_id: GO:2001181 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "activation of interleukin-10 production" NARROW [] synonym: "positive regulation of IL-10 production" EXACT [] +synonym: "positive regulation of interleukin-10 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-10 secretion" NARROW [] synonym: "stimulation of interleukin-10 production" NARROW [] synonym: "up regulation of interleukin-10 production" EXACT [] synonym: "up-regulation of interleukin-10 production" EXACT [] @@ -187954,9 +188553,13 @@ relationship: positively_regulates GO:0032613 ! interleukin-10 production id: GO:0032734 name: positive regulation of interleukin-11 production namespace: biological_process +alt_id: GO:0045365 +alt_id: GO:0150171 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "activation of interleukin-11 production" NARROW [] synonym: "positive regulation of IL-11 production" EXACT [] +synonym: "positive regulation of interleukin-11 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-11 secretion" NARROW [] synonym: "stimulation of interleukin-11 production" NARROW [] synonym: "up regulation of interleukin-11 production" EXACT [] synonym: "up-regulation of interleukin-11 production" EXACT [] @@ -187971,9 +188574,15 @@ relationship: positively_regulates GO:0032614 ! interleukin-11 production id: GO:0032735 name: positive regulation of interleukin-12 production namespace: biological_process +alt_id: GO:0045084 +alt_id: GO:2001184 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "activation of interleukin-12 production" NARROW [] +synonym: "positive regulation of CLMF production" RELATED [GOC:obol] synonym: "positive regulation of IL-12 production" EXACT [] +synonym: "positive regulation of interleukin-12 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-12 secretion" NARROW [] +synonym: "positive regulation of NKSF production" RELATED [GOC:obol] synonym: "stimulation of interleukin-12 production" NARROW [] synonym: "up regulation of interleukin-12 production" EXACT [] synonym: "up-regulation of interleukin-12 production" EXACT [] @@ -187988,9 +188597,13 @@ relationship: positively_regulates GO:0032615 ! interleukin-12 production id: GO:0032736 name: positive regulation of interleukin-13 production namespace: biological_process +alt_id: GO:0045368 +alt_id: GO:2000667 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "activation of interleukin-13 production" NARROW [] synonym: "positive regulation of IL-13 production" EXACT [] +synonym: "positive regulation of interleukin-13 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-13 secretion" NARROW [] synonym: "stimulation of interleukin-13 production" NARROW [] synonym: "up regulation of interleukin-13 production" EXACT [] synonym: "up-regulation of interleukin-13 production" EXACT [] @@ -188005,9 +188618,11 @@ relationship: positively_regulates GO:0032616 ! interleukin-13 production id: GO:0032737 name: positive regulation of interleukin-14 production namespace: biological_process +alt_id: GO:0045371 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "activation of interleukin-14 production" NARROW [] synonym: "positive regulation of IL-14 production" EXACT [] +synonym: "positive regulation of interleukin-14 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-14 production" NARROW [] synonym: "up regulation of interleukin-14 production" EXACT [] synonym: "up-regulation of interleukin-14 production" EXACT [] @@ -188022,9 +188637,11 @@ relationship: positively_regulates GO:0032617 ! interleukin-14 production id: GO:0032738 name: positive regulation of interleukin-15 production namespace: biological_process +alt_id: GO:0045374 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "activation of interleukin-15 production" NARROW [] synonym: "positive regulation of IL-15 production" EXACT [] +synonym: "positive regulation of interleukin-15 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-15 production" NARROW [] synonym: "up regulation of interleukin-15 production" EXACT [] synonym: "up-regulation of interleukin-15 production" EXACT [] @@ -188039,9 +188656,11 @@ relationship: positively_regulates GO:0032618 ! interleukin-15 production id: GO:0032739 name: positive regulation of interleukin-16 production namespace: biological_process +alt_id: GO:0045377 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "activation of interleukin-16 production" NARROW [] synonym: "positive regulation of IL-16 production" EXACT [] +synonym: "positive regulation of interleukin-16 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-16 production" NARROW [] synonym: "up regulation of interleukin-16 production" EXACT [] synonym: "up-regulation of interleukin-16 production" EXACT [] @@ -188056,9 +188675,15 @@ relationship: positively_regulates GO:0032619 ! interleukin-16 production id: GO:0032740 name: positive regulation of interleukin-17 production namespace: biological_process -def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah] +alt_id: GO:0045380 +alt_id: GO:1905078 +def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511] synonym: "activation of interleukin-17 production" NARROW [] +synonym: "positive regulation of CTLA-8 production" EXACT [GOC:TermGenie] +synonym: "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:TermGenie] synonym: "positive regulation of IL-17 production" EXACT [] +synonym: "positive regulation of interleukin-17 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-17 secretion" NARROW [] synonym: "stimulation of interleukin-17 production" NARROW [] synonym: "up regulation of interleukin-17 production" EXACT [] synonym: "up-regulation of interleukin-17 production" EXACT [] @@ -188073,9 +188698,13 @@ relationship: positively_regulates GO:0032620 ! interleukin-17 production id: GO:0032741 name: positive regulation of interleukin-18 production namespace: biological_process +alt_id: GO:0045383 +alt_id: GO:0150122 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "activation of interleukin-18 production" NARROW [] synonym: "positive regulation of IL-18 production" EXACT [] +synonym: "positive regulation of interleukin-18 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-18 secretion" NARROW [] synonym: "stimulation of interleukin-18 production" NARROW [] synonym: "up regulation of interleukin-18 production" EXACT [] synonym: "up-regulation of interleukin-18 production" EXACT [] @@ -188090,9 +188719,11 @@ relationship: positively_regulates GO:0032621 ! interleukin-18 production id: GO:0032742 name: positive regulation of interleukin-19 production namespace: biological_process +alt_id: GO:0045386 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "activation of interleukin-19 production" NARROW [] synonym: "positive regulation of IL-19 production" EXACT [] +synonym: "positive regulation of interleukin-19 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-19 production" NARROW [] synonym: "up regulation of interleukin-19 production" EXACT [] synonym: "up-regulation of interleukin-19 production" EXACT [] @@ -188107,9 +188738,13 @@ relationship: positively_regulates GO:0032622 ! interleukin-19 production id: GO:0032743 name: positive regulation of interleukin-2 production namespace: biological_process +alt_id: GO:0045086 +alt_id: GO:1900042 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "activation of interleukin-2 production" NARROW [] synonym: "positive regulation of IL-2 production" EXACT [] +synonym: "positive regulation of interleukin-2 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-2 secretion" NARROW [] synonym: "stimulation of interleukin-2 production" NARROW [] synonym: "up regulation of interleukin-2 production" EXACT [] synonym: "up-regulation of interleukin-2 production" EXACT [] @@ -188124,9 +188759,11 @@ relationship: positively_regulates GO:0032623 ! interleukin-2 production id: GO:0032744 name: positive regulation of interleukin-20 production namespace: biological_process +alt_id: GO:0045389 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "activation of interleukin-20 production" NARROW [] synonym: "positive regulation of IL-20 production" EXACT [] +synonym: "positive regulation of interleukin-20 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-20 production" NARROW [] synonym: "up regulation of interleukin-20 production" EXACT [] synonym: "up-regulation of interleukin-20 production" EXACT [] @@ -188141,9 +188778,11 @@ relationship: positively_regulates GO:0032624 ! interleukin-20 production id: GO:0032745 name: positive regulation of interleukin-21 production namespace: biological_process +alt_id: GO:0045392 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "activation of interleukin-21 production" NARROW [] synonym: "positive regulation of IL-21 production" EXACT [] +synonym: "positive regulation of interleukin-21 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-21 production" NARROW [] synonym: "up regulation of interleukin-21 production" EXACT [] synonym: "up-regulation of interleukin-21 production" EXACT [] @@ -188158,9 +188797,11 @@ relationship: positively_regulates GO:0032625 ! interleukin-21 production id: GO:0032746 name: positive regulation of interleukin-22 production namespace: biological_process +alt_id: GO:0045395 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "activation of interleukin-22 production" NARROW [] synonym: "positive regulation of IL-22 production" EXACT [] +synonym: "positive regulation of interleukin-22 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-22 production" NARROW [] synonym: "up regulation of interleukin-22 production" EXACT [] synonym: "up-regulation of interleukin-22 production" EXACT [] @@ -188175,9 +188816,11 @@ relationship: positively_regulates GO:0032626 ! interleukin-22 production id: GO:0032747 name: positive regulation of interleukin-23 production namespace: biological_process +alt_id: GO:0045398 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "activation of interleukin-23 production" NARROW [] synonym: "positive regulation of IL-23 production" EXACT [] +synonym: "positive regulation of interleukin-23 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-23 production" NARROW [] synonym: "up regulation of interleukin-23 production" EXACT [] synonym: "up-regulation of interleukin-23 production" EXACT [] @@ -188192,9 +188835,11 @@ relationship: positively_regulates GO:0032627 ! interleukin-23 production id: GO:0032748 name: positive regulation of interleukin-24 production namespace: biological_process +alt_id: GO:0045536 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "activation of interleukin-24 production" NARROW [] synonym: "positive regulation of IL-24 production" EXACT [] +synonym: "positive regulation of interleukin-24 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-24 production" NARROW [] synonym: "up regulation of interleukin-24 production" EXACT [] synonym: "up-regulation of interleukin-24 production" EXACT [] @@ -188209,9 +188854,13 @@ relationship: positively_regulates GO:0032628 ! interleukin-24 production id: GO:0032749 name: positive regulation of interleukin-25 production namespace: biological_process +alt_id: GO:0045537 +alt_id: GO:0150150 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "activation of interleukin-25 production" NARROW [] synonym: "positive regulation of IL-25 production" EXACT [] +synonym: "positive regulation of interleukin-25 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-25 secretion" NARROW [] synonym: "stimulation of interleukin-25 production" NARROW [] synonym: "up regulation of interleukin-25 production" EXACT [] synonym: "up-regulation of interleukin-25 production" EXACT [] @@ -188221,14 +188870,18 @@ is_a: GO:0032669 ! regulation of interleukin-25 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0032629 ! interleukin-25 production relationship: positively_regulates GO:0032629 ! interleukin-25 production +created_by: bc +creation_date: 2019-12-09T16:51:44Z [Term] id: GO:0032750 name: positive regulation of interleukin-26 production namespace: biological_process +alt_id: GO:0045538 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "activation of interleukin-26 production" NARROW [] synonym: "positive regulation of IL-26 production" EXACT [] +synonym: "positive regulation of interleukin-26 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-26 production" NARROW [] synonym: "up regulation of interleukin-26 production" EXACT [] synonym: "up-regulation of interleukin-26 production" EXACT [] @@ -188243,9 +188896,12 @@ relationship: positively_regulates GO:0032630 ! interleukin-26 production id: GO:0032751 name: positive regulation of interleukin-27 production namespace: biological_process +alt_id: GO:0045539 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "activation of interleukin-27 production" NARROW [] synonym: "positive regulation of IL-27 production" EXACT [] +synonym: "positive regulation of interleukin-27 anabolism" NARROW [] +synonym: "positive regulation of interleukin-27 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-27 production" NARROW [] synonym: "up regulation of interleukin-27 production" EXACT [] synonym: "up-regulation of interleukin-27 production" EXACT [] @@ -188260,9 +188916,11 @@ relationship: positively_regulates GO:0032631 ! interleukin-27 production id: GO:0032752 name: positive regulation of interleukin-3 production namespace: biological_process +alt_id: GO:0045401 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "activation of interleukin-3 production" NARROW [] synonym: "positive regulation of IL-3 production" EXACT [] +synonym: "positive regulation of interleukin-3 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-3 production" NARROW [] synonym: "up regulation of interleukin-3 production" EXACT [] synonym: "up-regulation of interleukin-3 production" EXACT [] @@ -188277,9 +188935,13 @@ relationship: positively_regulates GO:0032632 ! interleukin-3 production id: GO:0032753 name: positive regulation of interleukin-4 production namespace: biological_process +alt_id: GO:0045404 +alt_id: GO:0150135 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "activation of interleukin-4 production" NARROW [] synonym: "positive regulation of IL-4 production" EXACT [] +synonym: "positive regulation of interleukin-4 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-4 secretion" NARROW [] synonym: "stimulation of interleukin-4 production" NARROW [] synonym: "up regulation of interleukin-4 production" EXACT [] synonym: "up-regulation of interleukin-4 production" EXACT [] @@ -188294,9 +188956,13 @@ relationship: positively_regulates GO:0032633 ! interleukin-4 production id: GO:0032754 name: positive regulation of interleukin-5 production namespace: biological_process +alt_id: GO:0045407 +alt_id: GO:2000664 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "activation of interleukin-5 production" NARROW [] synonym: "positive regulation of IL-5 production" EXACT [] +synonym: "positive regulation of interleukin-5 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-5 secretion" NARROW [] synonym: "stimulation of interleukin-5 production" NARROW [] synonym: "up regulation of interleukin-5 production" EXACT [] synonym: "up-regulation of interleukin-5 production" EXACT [] @@ -188311,9 +188977,13 @@ relationship: positively_regulates GO:0032634 ! interleukin-5 production id: GO:0032755 name: positive regulation of interleukin-6 production namespace: biological_process +alt_id: GO:0045410 +alt_id: GO:2000778 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "activation of interleukin-6 production" NARROW [] synonym: "positive regulation of IL-6 production" EXACT [] +synonym: "positive regulation of interleukin-6 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-6 secretion" NARROW [] synonym: "stimulation of interleukin-6 production" NARROW [] synonym: "up regulation of interleukin-6 production" EXACT [] synonym: "up-regulation of interleukin-6 production" EXACT [] @@ -188328,9 +188998,13 @@ relationship: positively_regulates GO:0032635 ! interleukin-6 production id: GO:0032756 name: positive regulation of interleukin-7 production namespace: biological_process +alt_id: GO:0045413 +alt_id: GO:0150114 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "activation of interleukin-7 production" NARROW [] synonym: "positive regulation of IL-7 production" EXACT [] +synonym: "positive regulation of interleukin-7 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-7 secretion" NARROW [] synonym: "stimulation of interleukin-7 production" NARROW [] synonym: "up regulation of interleukin-7 production" EXACT [] synonym: "up-regulation of interleukin-7 production" EXACT [] @@ -188345,9 +189019,13 @@ relationship: positively_regulates GO:0032636 ! interleukin-7 production id: GO:0032757 name: positive regulation of interleukin-8 production namespace: biological_process +alt_id: GO:0045416 +alt_id: GO:2000484 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "activation of interleukin-8 production" NARROW [] synonym: "positive regulation of IL-8 production" EXACT [] +synonym: "positive regulation of interleukin-8 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-8 secretion" NARROW [] synonym: "stimulation of interleukin-8 production" NARROW [] synonym: "up regulation of interleukin-8 production" EXACT [] synonym: "up-regulation of interleukin-8 production" EXACT [] @@ -188362,9 +189040,11 @@ relationship: positively_regulates GO:0032637 ! interleukin-8 production id: GO:0032758 name: positive regulation of interleukin-9 production namespace: biological_process +alt_id: GO:0045419 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "activation of interleukin-9 production" NARROW [] synonym: "positive regulation of IL-9 production" EXACT [] +synonym: "positive regulation of interleukin-9 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-9 production" NARROW [] synonym: "up regulation of interleukin-9 production" EXACT [] synonym: "up-regulation of interleukin-9 production" EXACT [] @@ -188669,6 +189349,7 @@ id: GO:0032782 name: bile acid secretion namespace: biological_process def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd] +is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0046717 ! acid secretion @@ -188833,8 +189514,8 @@ def: "A protein complex that contains the survival motor neuron (SMN) protein an comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'. synonym: "SMN core complex" EXACT [] synonym: "survival motor neuron complex" EXACT [] -is_a: GO:0032991 ! protein-containing complex -relationship: part_of GO:0005622 ! intracellular +is_a: GO:0120114 ! Sm-like protein family complex +relationship: part_of GO:0034719 ! SMN-Sm protein complex [Term] id: GO:0032798 @@ -189482,7 +190163,6 @@ id: GO:0032841 name: calcitonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd] -is_a: GO:0008144 ! drug binding is_a: GO:0097644 ! calcitonin family binding [Term] @@ -189557,7 +190237,7 @@ relationship: positively_regulates GO:0051452 ! intracellular pH reduction id: GO:0032865 name: ERMES complex namespace: cellular_component -def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth." [GOC:mcc, PMID:19556461] +def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles." [GOC:mcc, PMID:19556461, PMID:29279306] synonym: "ER-mitochondria encounter structure" EXACT [] synonym: "Mdm10/Mdm12/Mmm1 complex" EXACT [] synonym: "mitochore" EXACT [GOC:mcc] @@ -189790,7 +190470,6 @@ name: regulation of chitin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah] synonym: "regulation of chitin metabolism" EXACT [] -is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process @@ -191322,6 +192001,7 @@ id: GO:0033013 name: tetrapyrrole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] +subset: goslim_pombe synonym: "tetrapyrrole metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process @@ -191738,7 +192418,6 @@ name: clavulanic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [GOC:mah] synonym: "clavulanic acid metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process @@ -191755,7 +192434,6 @@ synonym: "clavulanic acid biosynthesis" EXACT [] synonym: "clavulanic acid formation" EXACT [] synonym: "clavulanic acid synthesis" EXACT [] xref: Wikipedia:Clavulanic_acid -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0033049 ! clavulanic acid metabolic process is_a: GO:0043604 ! amide biosynthetic process @@ -191767,8 +192445,9 @@ is_a: GO:1901566 ! organonitrogen compound biosynthetic process id: GO:0033051 name: aminophosphonate metabolic process namespace: biological_process -def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah, http://pages.unibas.ch/mdpi/ecsoc/a0045/a0045.htm, KEGG:map00440] +def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah] synonym: "aminophosphonate metabolism" EXACT [] +xref: KEGG_PATHWAY:map00440 is_a: GO:0019634 ! organic phosphonate metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process @@ -191847,7 +192526,7 @@ is_a: GO:0043473 ! pigmentation id: GO:0033061 name: DNA recombinase mediator complex namespace: cellular_component -def: "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA." [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992] +def: "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange." [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992, PMID:32414915] comment: Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly. subset: goslim_pir is_a: GO:0032991 ! protein-containing complex @@ -193296,9 +193975,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl] synonym: "response to adenosine 5'-triphosphate" EXACT [] synonym: "response to adenosine triphosphate" EXACT [] -is_a: GO:0007584 ! response to nutrient is_a: GO:0014074 ! response to purine-containing compound -is_a: GO:0042493 ! response to drug is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound @@ -193521,7 +194198,7 @@ namespace: biological_process def: "The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] synonym: "2-phosphonoethylamine transport" EXACT [] synonym: "ciliatine transport" EXACT [] -is_a: GO:0071702 ! organic substance transport +is_a: GO:0015695 ! organic cation transport is_a: GO:0071705 ! nitrogen compound transport [Term] @@ -193531,7 +194208,8 @@ namespace: molecular_function def: "Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other." [GOC:mlg] synonym: "2-phosphonoethylamine transmembrane transporter activity" EXACT [] synonym: "ciliatine transporter activity" EXACT [] -is_a: GO:0022804 ! active transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity relationship: part_of GO:0033223 ! 2-aminoethylphosphonate transport [Term] @@ -193546,7 +194224,7 @@ synonym: "ATP-dependent 2-aminoethylphosphonate transporter activity" EXACT [] synonym: "ciliatine transportingATPase activity" EXACT [] xref: RHEA:32775 is_a: GO:0033224 ! 2-aminoethylphosphonate transmembrane transporter activity -is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity +is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity [Term] id: GO:0033226 @@ -193555,7 +194233,7 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with 2-aminoethylphosphonate." [GOC:mlg] synonym: "2-phosphonoethylamine binding" EXACT [] synonym: "ciliatine binding" EXACT [] -is_a: GO:0005488 ! binding +is_a: GO:0043169 ! cation binding [Term] id: GO:0033227 @@ -193673,8 +194351,6 @@ synonym: "11-beta-hydroxysteroid dehydrogenase (NADP+) activity" EXACT [] synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146] -xref: EC:1.1.1.146 -xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN is_obsolete: true replaced_by: GO:0070524 @@ -194009,8 +194685,6 @@ comment: This term was made obsolete because it represents a gene product. synonym: "BoNT" RELATED [EC:3.4.24.69] synonym: "bontoxilysin activity" EXACT [] synonym: "botulinum neurotoxin activity" EXACT [] -xref: EC:3.4.24.69 -xref: MetaCyc:3.4.24.69-RXN is_obsolete: true replaced_by: GO:0004222 @@ -194019,7 +194693,6 @@ id: GO:0033265 name: choline binding namespace: molecular_function def: "Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [GOC:mlg] -is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043169 ! cation binding [Term] @@ -194090,7 +194763,6 @@ name: myo-inositol hexakisphosphate transport namespace: biological_process def: "The directed movement of myo-inositol hexakisphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "phytate transport" EXACT [] -is_a: GO:0015893 ! drug transport is_a: GO:0033271 ! myo-inositol phosphate transport [Term] @@ -194109,7 +194781,6 @@ synonym: "response to riboflavin" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin -is_a: GO:0042493 ! response to drug [Term] id: GO:0033275 @@ -194347,7 +195018,8 @@ namespace: molecular_function def: "Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other." [GOC:go_curators] synonym: "dehydroascorbate transporter activity" EXACT [] synonym: "dehydroascorbic acid transporter activity" RELATED [] -xref: Reactome:R-HSA-198818 "GLUT1/3 transports extracellular DHvitC to cytosol" +xref: Reactome:R-HSA-198818 "SLC2A1,3 transports DeHA from extracellular region to cytosol" +xref: RHEA:60380 is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:0070837 ! dehydroascorbic acid transport @@ -194410,7 +195082,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [GOC:mah] synonym: "phytol metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:1903173 ! fatty alcohol metabolic process @@ -194647,7 +195318,6 @@ name: kaempferol O-glucoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [GOC:mah, MetaCyc:PWY-5320] synonym: "kaempferol O-glucoside metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0051552 ! flavone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process is_a: GO:1901804 ! beta-glucoside metabolic process @@ -194662,7 +195332,6 @@ synonym: "kaempferol O-glucoside biosynthesis" EXACT [] synonym: "kaempferol O-glucoside formation" EXACT [] synonym: "kaempferol O-glucoside synthesit" EXACT [] xref: MetaCyc:PWY-5320 -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0033329 ! kaempferol O-glucoside metabolic process is_a: GO:0051553 ! flavone biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process @@ -196387,7 +197056,6 @@ name: ferulate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [GOC:mah] synonym: "ferulate metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process @@ -196563,7 +197231,6 @@ name: luteolin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [GOC:mah] synonym: "luteolin metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0051552 ! flavone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process @@ -196641,7 +197308,6 @@ def: "The chemical reactions and pathways involving phytic acid, myo-inositol he synonym: "myo-inositol hexakisphosphate metabolism" EXACT [] synonym: "phytate metabolic process" EXACT [] synonym: "phytate metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0043647 ! inositol phosphate metabolic process [Term] @@ -197083,6 +197749,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pde] xref: Reactome:R-HSA-197963 "Folate is reduced to dihydrofolate (DHF)" xref: Reactome:R-HSA-197972 "DHF is reduced to tetrahydrofolate (THF)" +xref: RHEA:31103 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] @@ -197208,7 +197875,6 @@ name: response to testosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl] synonym: "response to testosterone stimulus" EXACT [GOC:dos] -is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901654 ! response to ketone @@ -197379,7 +198045,6 @@ synonym: "response to vitamin B12" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin -is_a: GO:0042493 ! response to drug [Term] id: GO:0033591 @@ -197389,7 +198054,6 @@ def: "Any process that results in a change in state or activity of a cell or an synonym: "response to ascorbic acid" BROAD [] synonym: "response to L-ascorbate" EXACT [] synonym: "response to vitamin C" EXACT [] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0033273 ! response to vitamin is_a: GO:0034284 ! response to monosaccharide @@ -197423,9 +198087,7 @@ id: GO:0033595 name: response to genistein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah] -is_a: GO:0009725 ! response to hormone is_a: GO:0033594 ! response to hydroxyisoflavone -is_a: GO:0097327 ! response to antineoplastic agent [Term] id: GO:0033596 @@ -197515,7 +198177,6 @@ is_a: GO:0014059 ! regulation of dopamine secretion is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0033604 ! negative regulation of catecholamine secretion is_a: GO:0043271 ! negative regulation of ion transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014046 ! dopamine secretion relationship: negatively_regulates GO:0014046 ! dopamine secretion @@ -197535,7 +198196,6 @@ is_a: GO:0014059 ! regulation of dopamine secretion is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0033605 ! positive regulation of catecholamine secretion is_a: GO:0043270 ! positive regulation of ion transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014046 ! dopamine secretion relationship: positively_regulates GO:0014046 ! dopamine secretion @@ -197975,6 +198635,7 @@ is_a: GO:0018995 ! host cellular component intersection_of: GO:0018995 ! host cellular component intersection_of: part_of GO:0043657 ! host cell relationship: part_of GO:0043657 ! host cell +property_value: RO:0002161 NCBITaxon:7742 [Term] id: GO:0033644 @@ -198324,6 +198985,7 @@ def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction driv synonym: "5' to 3' DNA/RNA helicase activity" EXACT [] synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT [] synonym: "ATP-dependent 5'-3' DNA/RNA helicase activity" EXACT [] +xref: Reactome:R-HSA-163120 "Disassociation of Telomerase RNP and the Chromosome End" is_a: GO:0033677 ! DNA/RNA helicase activity [Term] @@ -198780,6 +199442,7 @@ synonym: "2-oxoacid reductase activity" EXACT [EC:1.1.99.30] synonym: "HVOR" RELATED [EC:1.1.99.30] xref: EC:1.1.99.30 xref: MetaCyc:1.1.99.30-RXN +xref: RHEA:23664 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] @@ -198841,6 +199504,7 @@ synonym: "AOR" RELATED [EC:1.2.7.5] synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5] xref: EC:1.2.7.5 xref: MetaCyc:1.2.7.5-RXN +xref: RHEA:16421 is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] @@ -198993,6 +199657,7 @@ synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1] synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" EXACT [EC:1.5.7.1] xref: EC:1.5.7.1 xref: MetaCyc:RXN-5061 +xref: RHEA:14229 is_a: GO:0033694 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor [Term] @@ -199197,6 +199862,7 @@ synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52] xref: EC:1.13.11.52 xref: MetaCyc:RXN-8664 xref: MetaCyc:RXN-8665 +xref: RHEA:14189 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] @@ -199252,6 +199918,7 @@ synonym: "clavaminic acid synthase activity" EXACT [EC:1.14.11.21] synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.21] xref: EC:1.14.11.21 xref: MetaCyc:1.14.11.21-RXN +xref: RHEA:20021 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] @@ -199523,6 +200190,7 @@ synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" EXACT [EC:1.14.1 synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" EXACT [EC:1.14.13.97] xref: EC:1.14.13.97 xref: MetaCyc:RXN-7977 +xref: RHEA:23644 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -199595,6 +200263,7 @@ def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-be synonym: "D-alpha,beta-D-heptose 7-phosphate 1-kinase activity" EXACT [] xref: EC:2.7.1 xref: MetaCyc:RXN0-4341 +xref: RHEA:27473 is_a: GO:0019200 ! carbohydrate kinase activity [Term] @@ -199605,6 +200274,7 @@ def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glyc synonym: "D-beta-D-heptose 1-phosphate adenylyltransferase activity" EXACT [] synonym: "heptose 1-phosphate adenyltransferase activity" EXACT [] xref: MetaCyc:RXN0-4342 +xref: RHEA:27465 is_a: GO:0070566 ! adenylyltransferase activity [Term] @@ -199726,6 +200396,7 @@ synonym: "sulphur reductase activity" EXACT [] xref: EC:1.12.98.4 xref: MetaCyc:1.97.1.3-RXN xref: MetaCyc:RXN-8269 +xref: RHEA:35591 is_a: GO:0016491 ! oxidoreductase activity [Term] @@ -199762,7 +200433,7 @@ id: GO:0033799 name: myricetin 3'-O-methyltransferase activity namespace: molecular_function alt_id: GO:0102437 -def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [MetaCyc:RXN-8451, RHEA:25629] +def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [RHEA:25629] comment: Note that this term represents one of two reactions that are grouped together in EC:2.1.1.267 synonym: "CrCOMT2" RELATED [] synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [] @@ -199796,6 +200467,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L- synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" EXACT [EC:2.1.1.153] xref: EC:2.1.1.153 xref: MetaCyc:RXN-4981 +xref: RHEA:11432 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity @@ -199907,6 +200579,7 @@ synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferas synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171] xref: EC:2.3.1.171 xref: MetaCyc:2.3.1.171-RXN +xref: RHEA:16025 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -200027,6 +200700,7 @@ synonym: "KAS II" RELATED [EC:2.3.1.179] synonym: "KASII" RELATED [EC:2.3.1.179] xref: EC:2.3.1.179 xref: MetaCyc:2.3.1.179-RXN +xref: RHEA:14565 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -200129,6 +200803,7 @@ synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" EXACT xref: EC:2.4.1.66 xref: MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-1981157 "Glucosylation of collagen propeptide hydroxylysines" +xref: RHEA:12576 is_a: GO:0046527 ! glucosyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -200223,6 +200898,7 @@ synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" EXACT [EC: synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" EXACT [EC:2.4.1.229] synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229] xref: EC:2.4.1.229 +xref: RHEA:17841 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -200246,6 +200922,7 @@ def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glu synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.231] synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231] xref: MetaCyc:RXN-4441 +xref: RHEA:16257 is_a: GO:0046527 ! glucosyltransferase activity [Term] @@ -200265,6 +200942,7 @@ synonym: "F3GalTase activity" EXACT [EC:2.4.1.234] synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.234] xref: EC:2.4.1.234 xref: MetaCyc:2.4.1.234-RXN +xref: RHEA:15709 is_a: GO:0008378 ! galactosyltransferase activity [Term] @@ -200281,6 +200959,7 @@ xref: MetaCyc:RXN-5002 xref: MetaCyc:RXN-5004 xref: MetaCyc:RXN-7759 xref: MetaCyc:RXN-9699 +xref: RHEA:15473 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -200305,6 +200984,7 @@ synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" EXAC synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" EXACT [EC:2.4.1.238] xref: EC:2.4.1.238 xref: MetaCyc:2.4.1.238-RXN +xref: RHEA:35627 is_a: GO:0046527 ! glucosyltransferase activity [Term] @@ -200347,6 +201027,7 @@ synonym: "starch synthase II activity" EXACT [EC:2.4.1.242] synonym: "waxy protein" RELATED [EC:2.4.1.242] xref: EC:2.4.1.242 xref: MetaCyc:2.4.1.242-RXN +xref: RHEA:15873 is_a: GO:0046527 ! glucosyltransferase activity [Term] @@ -200598,6 +201279,7 @@ synonym: "GK2" RELATED [EC:2.7.1.157] synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" EXACT [EC:2.7.1.157] xref: EC:2.7.1.157 xref: MetaCyc:2.7.1.157-RXN +xref: RHEA:12617 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity @@ -200928,6 +201610,7 @@ synonym: "vitamin B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74] synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74] xref: EC:3.1.3.74 xref: MetaCyc:3.1.3.74-RXN +xref: RHEA:20533 is_a: GO:0016791 ! phosphatase activity [Term] @@ -201377,6 +202060,7 @@ synonym: "exopolygalacturanosidase activity" EXACT [EC:3.2.1.82] synonym: "exopolygalacturonosidase activity" EXACT [EC:3.2.1.82] xref: EC:3.2.1.82 xref: MetaCyc:3.2.1.82-RXN +xref: RHEA:56232 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -201402,6 +202086,7 @@ xref: EC:3.2.1.84 xref: MetaCyc:3.2.1.84-RXN xref: Reactome:R-HSA-532667 "Removal of the second glucose by glucosidase II" xref: Reactome:R-HSA-548890 "Removal of the third glucose by glucosidase II and release from the chaperone" +xref: Reactome:R-HSA-9683663 "N-glycan trimming of Spike" is_a: GO:0090600 ! alpha-1,3-glucosidase activity [Term] @@ -201416,6 +202101,7 @@ synonym: "phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85] synonym: "phospho-beta-galactosidase activity" EXACT [EC:3.2.1.85] xref: EC:3.2.1.85 xref: MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN +xref: RHEA:24568 is_a: GO:0015925 ! galactosidase activity [Term] @@ -201871,6 +202557,7 @@ synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidas xref: EC:3.2.1.161 xref: MetaCyc:3.2.1.161-RXN xref: MetaCyc:RXN-9156 +xref: RHEA:21488 is_a: GO:0008422 ! beta-glucosidase activity [Term] @@ -202007,6 +202694,7 @@ def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine synonym: "N-benzylformamide amidohydrolase activity" EXACT [EC:3.5.1.91] synonym: "NfdA" RELATED [EC:3.5.1.91] xref: MetaCyc:3.5.1.91-RXN +xref: RHEA:12096 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -202155,6 +202843,7 @@ synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.11] synonym: "DL-DEXr" RELATED [EC:3.8.1.11] xref: EC:3.8.1.11 xref: MetaCyc:3.8.1.11-RXN +xref: RHEA:12072 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] @@ -202278,7 +202967,6 @@ id: GO:0033986 name: response to methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:sl] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0097305 ! response to alcohol [Term] @@ -202320,6 +203008,7 @@ xref: EC:4.2.1.107 xref: MetaCyc:4.2.1.107-RXN xref: Reactome:R-HSA-192331 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA" xref: Reactome:R-HSA-193535 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA" +xref: RHEA:18933 is_a: GO:0016836 ! hydro-lyase activity [Term] @@ -202350,6 +203039,7 @@ synonym: "AUDH" RELATED [EC:4.2.1.110] synonym: "pyranosone dehydratase activity" EXACT [EC:4.2.1.110] xref: EC:4.2.1.110 xref: MetaCyc:4.2.1.110-RXN +xref: RHEA:12100 is_a: GO:0016836 ! hydro-lyase activity [Term] @@ -202528,6 +203218,7 @@ synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)- xref: EC:4.2.3.22 xref: KEGG_REACTION:R07647 xref: MetaCyc:RXN-8648 +xref: RHEA:22436 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] @@ -202641,6 +203332,7 @@ synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" EXACT [EC:4.6.1.15] synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" EXACT [EC:4.6.1.15] synonym: "FMN cyclase activity" EXACT [EC:4.6.1.15] xref: EC:4.6.1.15 +xref: RHEA:13729 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity @@ -202654,6 +203346,7 @@ synonym: "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.99.1.5] synonym: "OxdA" RELATED [EC:4.99.1.5] xref: EC:4.99.1.5 xref: MetaCyc:4.99.1.5-RXN +xref: RHEA:11316 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] @@ -202711,6 +203404,7 @@ synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] synonym: "trans-2-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] xref: EC:5.3.3.14 xref: MetaCyc:5.3.3.14-RXN +xref: RHEA:23568 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] @@ -202823,6 +203517,7 @@ synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12] synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" EXACT [EC:6.3.1.12] xref: EC:6.3.1.12 xref: MetaCyc:6.3.1.12-RXN +xref: RHEA:10752 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] @@ -202987,6 +203682,7 @@ xref: EC:2.5.1.46 xref: MetaCyc:2.5.1.46-RXN xref: Reactome:R-HSA-204617 "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A" xref: Reactome:R-HSA-204647 "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine" +xref: RHEA:33299 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] @@ -203353,6 +204049,7 @@ name: marneral synthase activity namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581] xref: MetaCyc:RXN-9664 +xref: RHEA:31875 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] @@ -203362,6 +204059,7 @@ namespace: molecular_function def: "Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)." [GOC:cb, PMID:16774269, PMID:17474751] xref: EC:4.2.1.124 xref: MetaCyc:RXN-9684 +xref: RHEA:31035 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] @@ -204749,6 +205447,7 @@ name: D,D-heptose 1,7-bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate." [MetaCyc:RXN0-4361, PMID:11279237] xref: MetaCyc:RXN0-4361 +xref: RHEA:28518 is_a: GO:0016791 ! phosphatase activity [Term] @@ -204865,7 +205564,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of quinolin synonym: "quinolinate breakdown" EXACT [] synonym: "quinolinate catabolism" EXACT [] synonym: "quinolinate degradation" EXACT [] -is_a: GO:0042737 ! drug catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0046874 ! quinolinate metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process @@ -205022,6 +205720,8 @@ namespace: biological_process def: "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066] synonym: "tRNA sulfurtransferase activity" RELATED [GOC:mah] synonym: "tRNA thiolation" EXACT [PMID:24774365] +xref: EC:2.8.1.4 +xref: MetaCyc:TRNA-S-TRANSFERASE-RXN is_a: GO:0006400 ! tRNA modification [Term] @@ -205093,7 +205793,6 @@ def: "Any process that modulates the frequency, rate or extent of the chemical r synonym: "regulation of cell wall chitin breakdown" EXACT [] synonym: "regulation of cell wall chitin catabolism" EXACT [] synonym: "regulation of cell wall chitin degradation" EXACT [] -is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0034222 ! regulation of cell wall chitin metabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process intersection_of: GO:0008150 ! biological_process @@ -205244,7 +205943,7 @@ alt_id: GO:0000998 alt_id: GO:0001142 alt_id: GO:0001143 alt_id: GO:0001144 -def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by mitochondrial RNA polymerase." [GOC:txnOH-2018, PMID:18391175] +def: "Interacting selectively and non-covalently with a specific double-stranded mitochondrial DNA sequence in order to modulate transcription by mitochondrial RNA polymerase." [GOC:txnOH-2018, PMID:18391175] synonym: "mitochondrial polymerase transcription factor activity" EXACT [] synonym: "mitochondrial RNA polymerase binding promoter specificity activity" EXACT [] synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" EXACT [] @@ -205589,7 +206288,6 @@ def: "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyqui synonym: "4-hydroxyquinoline-2-carboxylic acid metabolic process" EXACT [] synonym: "kynurenic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -205628,7 +206326,7 @@ is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates id: GO:0034278 name: stemar-13-ene synthase activity namespace: molecular_function -def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." [MetaCyc:RXN-4882, RHEA:25552] +def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." [RHEA:25552] synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09115] xref: EC:4.2.3.33 xref: KEGG_REACTION:R09115 @@ -205640,7 +206338,7 @@ is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates id: GO:0034279 name: syn-pimara-7,15-diene synthase activity namespace: molecular_function -def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate." [MetaCyc:RXN-4883, RHEA:25560] +def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate." [RHEA:25560] synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09117] xref: EC:4.2.3.35 xref: KEGG_REACTION:R09117 @@ -205652,7 +206350,7 @@ is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates id: GO:0034280 name: ent-sandaracopimaradiene synthase activity namespace: molecular_function -def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate." [MetaCyc:RXN-4884, RHEA:25536] +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate." [RHEA:25536] synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09120] synonym: "ent-pimaradiene synthase activity" BROAD [] xref: EC:4.2.3.29 @@ -206261,9 +206959,11 @@ relationship: part_of GO:0045087 ! innate immune response id: GO:0034343 name: type III interferon production namespace: biological_process +alt_id: GO:0072644 def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. synonym: "type III IFN production" EXACT [] +synonym: "type III interferon secretion" NARROW [] is_a: GO:0001816 ! cytokine production [Term] @@ -206723,6 +207423,7 @@ def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semiald synonym: "gamma-aminobutyric acid pyruvate transaminase activity" EXACT [EC:2.6.1.96] xref: EC:2.6.1.96 xref: MetaCyc:RXN-6902 +xref: RHEA:32263 is_a: GO:0003867 ! 4-aminobutyrate transaminase activity [Term] @@ -206869,7 +207570,7 @@ relationship: part_of GO:0031981 ! nuclear lumen id: GO:0034400 name: gerontoplast namespace: cellular_component -def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:16151876] +def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:24668747] is_a: GO:0009536 ! plastid [Term] @@ -207283,7 +207984,6 @@ namespace: molecular_function def: "OBSOLETE. Enables the transfer of a glycoprotein from one side of a membrane to the other." [GOC:BHF, GOC:mah, GOC:rl] comment: This term was obsoleted because there is no transmembrane transporter specific for glycoproteins. synonym: "glycoprotein transporter activity" RELATED [] -xref: Reactome:R-HSA-1022127 "OS9:SEL1:ERAD E3 ligase:DERL2 transports Ub-unfolded protein:(GlcNAc)2 (Man)9-5 from ERQC to cytosol" property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17130 xsd:anyURI is_obsolete: true @@ -207528,9 +208228,7 @@ id: GO:0034465 name: response to carbon monoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:ecd] -is_a: GO:0009636 ! response to toxic substance is_a: GO:0010033 ! response to organic substance -is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound [Term] @@ -207707,6 +208405,7 @@ namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate." [GOC:pf] xref: MetaCyc:RXN-10036 xref: Reactome:R-HSA-1675949 "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane" +xref: RHEA:25528 is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity @@ -207969,7 +208668,6 @@ def: "Any process that results in a change in state or activity of a cell or an is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin -is_a: GO:0042493 ! response to drug [Term] id: GO:0034517 @@ -208216,6 +208914,7 @@ name: fumarylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+." [UM-BBD_reactionID:r0811] xref: EC:3.7.1.20 +xref: RHEA:26168 xref: UM-BBD_reactionID:r0811 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances @@ -208723,6 +209422,7 @@ xref: KEGG_REACTION:R08549 xref: MetaCyc:2OXOGLUTARATEDEH-RXN xref: Reactome:R-HSA-71037 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+" xref: Reactome:R-HSA-71401 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+" +xref: RHEA:27786 is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity [Term] @@ -208867,8 +209567,6 @@ def: "Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6 synonym: "BH4 binding" EXACT [] synonym: "H4biopterin binding" EXACT [] synonym: "sapropterin binding" EXACT [] -is_a: GO:0008144 ! drug binding -is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding @@ -208983,6 +209681,9 @@ namespace: molecular_function def: "Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk] synonym: "retinol transporter activity" RELATED [] synonym: "vitamin A1 transporter activity" EXACT [] +xref: Reactome:R-HSA-1467466 "ABCA4 mediates atRAL transport" +xref: Reactome:R-HSA-2466749 "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol" +xref: Reactome:R-HSA-2466802 "Defective ABCA4 does not transport NRPE from disc membranes" is_a: GO:0005319 ! lipid transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity @@ -209004,7 +209705,6 @@ namespace: molecular_function def: "Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other." [GOC:mah] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042937 ! tripeptide transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity relationship: part_of GO:0034775 ! glutathione transmembrane transport @@ -209016,7 +209716,6 @@ namespace: biological_process def: "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015711 ! organic anion transport is_a: GO:0042939 ! tripeptide transport -is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:0072348 ! sulfur compound transport @@ -209179,7 +209878,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [GOC:BHF, GOC:mah, GOC:rl] synonym: "cortisol metabolism" EXACT [] is_a: GO:0008211 ! glucocorticoid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process @@ -209664,6 +210362,7 @@ name: allulose 6-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate." [GOC:imk] xref: MetaCyc:RXN0-304 +xref: RHEA:28426 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] @@ -209866,6 +210565,8 @@ def: "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, synonym: "gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] xref: EC:3.4.19.9 xref: MetaCyc:3.4.19.9-RXN +xref: RHEA:56784 +is_a: GO:0008234 ! cysteine-type peptidase activity is_a: GO:0008242 ! omega peptidase activity [Term] @@ -210387,6 +211088,7 @@ namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate." [EC:4.2.3.106, PMID:12624761] xref: EC:4.2.3.106 xref: MetaCyc:RXN-5109 +xref: RHEA:32691 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] @@ -210546,6 +211248,7 @@ namespace: molecular_function def: "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+." [UM-BBD_reactionID:r1034] xref: EC:1.14.13 xref: MetaCyc:RXN-10446 +xref: RHEA:35307 xref: UM-BBD_reactionID:r1034 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -211603,6 +212306,7 @@ name: 6-hydroxypseudooxynicotine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine." [UM-BBD_reactionID:r1441] xref: EC:1.5.99.14 +xref: RHEA:34223 xref: UM-BBD_reactionID:r1441 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors @@ -212182,6 +212886,7 @@ xref: Reactome:R-HSA-5685953 "SIRT6 deacetylates RBBP8" xref: Reactome:R-HSA-5688289 "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2" xref: Reactome:R-HSA-5688294 "SIRT5 deacetylates Cytochrome C" xref: Reactome:R-HSA-9620532 "SIRT1,SIRT3 deacetylate FOXO3" +xref: Reactome:R-HSA-9667952 "ANKLE2 is deacetylated by SIRT2" is_a: GO:0033558 ! protein deacetylase activity [Term] @@ -212391,6 +213096,7 @@ synonym: "phosphoinositide 3-kinase activity" EXACT [] xref: Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K" xref: Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3" xref: Reactome:R-HSA-9028519 "NTRK2-activated PI3K generates PIP3" +xref: Reactome:R-HSA-9670433 "KIT mutants:PI3K catalyze synthesis of PIP3" xref: Wikipedia:Phosphoinositide_3-kinase is_a: GO:0016301 ! kinase activity relationship: part_of GO:0046854 ! phosphatidylinositol phosphorylation @@ -213064,7 +213770,6 @@ id: GO:0035075 name: response to ecdysone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] -is_a: GO:0009725 ! response to hormone is_a: GO:0036314 ! response to sterol is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone @@ -213200,8 +213905,7 @@ id: GO:0035094 name: response to nicotine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089] -is_a: GO:0009636 ! response to toxic substance -is_a: GO:0042493 ! response to drug +is_a: GO:0042221 ! response to chemical [Term] id: GO:0035095 @@ -213267,6 +213971,8 @@ namespace: cellular_component def: "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108] synonym: "Facilitates chromatin transcription complex" EXACT [] is_a: GO:0008023 ! transcription elongation factor complex +relationship: part_of GO:0000790 ! nuclear chromatin +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19572 xsd:anyURI [Term] id: GO:0035102 @@ -214563,7 +215269,6 @@ id: GO:0035240 name: dopamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732] -is_a: GO:0008144 ! drug binding is_a: GO:0043169 ! cation binding is_a: GO:1901338 ! catecholamine binding @@ -214589,7 +215294,7 @@ def: "Catalysis of the addition of a second methyl group to methylated peptidyl- comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'. synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming)" RELATED [EC:2.1.1.319] synonym: "type I PRMT activity" RELATED [] -synonym: "type I protein arginine methyltransferase activity" RELATED [2.1.1.319] +synonym: "type I protein arginine methyltransferase activity" RELATED [EC:2.1.1.319] xref: EC:2.1.1.319 xref: RESID:AA0068 xref: RESID:AA0069 @@ -214875,7 +215580,6 @@ name: diphenyl phthalate binding namespace: molecular_function def: "Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com] synonym: "DPP binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding [Term] @@ -214885,7 +215589,6 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com] synonym: "DBP binding" EXACT [] synonym: "phthalic acid dibutyl ester binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding [Term] @@ -214893,7 +215596,6 @@ id: GO:0035276 name: ethanol binding namespace: molecular_function def: "Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732] -is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding is_a: GO:0043178 ! alcohol binding @@ -215713,8 +216415,7 @@ namespace: biological_process def: "The process in which flavin-adenine dinucleotide (FAD) is transported across a membrane. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [GOC:bf, ISBN:0198506732] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "FAD membrane transport" EXACT [] -is_a: GO:0015711 ! organic anion transport -is_a: GO:0051181 ! cofactor transport +is_a: GO:0015883 ! FAD transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport created_by: bf @@ -216046,8 +216747,8 @@ namespace: biological_process def: "The process in which carbon dioxide (CO2) is transported across a membrane." [GOC:yaf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "carbon dioxide membrane transport" EXACT [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015670 ! carbon dioxide transport +is_a: GO:0055085 ! transmembrane transport created_by: bf creation_date: 2010-03-18T11:17:54Z @@ -216692,7 +217393,6 @@ def: "Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dime synonym: "3',5'-cyclic di-GMP binding" EXACT [] synonym: "c-di-GMP binding" EXACT [] synonym: "cyclic dinucleotide di-GMP binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0030551 ! cyclic nucleotide binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding @@ -216782,7 +217482,6 @@ def: "The process in which borate is transported across a membrane. Borate is th comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "borate membrane transport" EXACT [] synonym: "boron transmembrane transport" RELATED [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0046713 ! borate transport is_a: GO:0098661 ! inorganic anion transmembrane transport created_by: bf @@ -216931,7 +217630,7 @@ creation_date: 2010-04-16T10:57:16Z id: GO:0035456 name: response to interferon-beta namespace: biological_process -def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374, PR:000008924] +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374] synonym: "response to beta-1 interferon" RELATED [GOC:sl] synonym: "response to fiblaferon" EXACT [GOC:sl] synonym: "response to fibroblast interferon" EXACT [GOC:sl] @@ -216944,7 +217643,7 @@ creation_date: 2010-04-16T11:06:12Z id: GO:0035457 name: cellular response to interferon-alpha namespace: biological_process -def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl, PR:000024938] +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl] synonym: "cellular response to interferon alfa-n1" RELATED [GOC:sl] synonym: "cellular response to interferon alfa-n3" RELATED [GOC:sl] synonym: "cellular response to leukocyte interferon" EXACT [GOC:sl] @@ -216959,7 +217658,7 @@ creation_date: 2010-04-16T11:08:29Z id: GO:0035458 name: cellular response to interferon-beta namespace: biological_process -def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PR:000024939] +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl] synonym: "cellular response to beta-1 interferon" RELATED [GOC:sl] synonym: "cellular response to fiblaferon" EXACT [GOC:sl] synonym: "cellular response to fibroblast interferon" EXACT [GOC:sl] @@ -217406,7 +218105,6 @@ def: "The chemical reactions and pathways involving the dipeptide beta-alanyl-L- synonym: "carnosine metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process created_by: bf creation_date: 2010-04-29T01:19:52Z @@ -217796,8 +218494,12 @@ creation_date: 2010-05-07T10:21:15Z id: GO:0035531 name: regulation of chemokine (C-C motif) ligand 6 production namespace: biological_process +alt_id: GO:0035534 +alt_id: GO:0035535 def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] +synonym: "chemokine (C-C motif) ligand 6 secretion" NARROW [] synonym: "regulation of CCL6 production" EXACT [] +synonym: "regulation of chemokine (C-C motif) ligand 6 secretion" NARROW [] is_a: GO:0032642 ! regulation of chemokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production @@ -217809,8 +218511,10 @@ creation_date: 2010-05-07T10:22:51Z id: GO:0035532 name: negative regulation of chemokine (C-C motif) ligand 6 production namespace: biological_process +alt_id: GO:0035536 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] synonym: "negative regulation of CCL6 production" EXACT [] +synonym: "negative regulation of chemokine (C-C motif) ligand 6 secretion" NARROW [] is_a: GO:0032682 ! negative regulation of chemokine production is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production intersection_of: GO:0008150 ! biological_process @@ -217823,8 +218527,10 @@ creation_date: 2010-05-07T10:23:40Z id: GO:0035533 name: positive regulation of chemokine (C-C motif) ligand 6 production namespace: biological_process +alt_id: GO:0035537 def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] synonym: "positive regulation of CCL6 production" EXACT [] +synonym: "positive regulation of chemokine (C-C motif) ligand 6 secretion" NARROW [] is_a: GO:0032722 ! positive regulation of chemokine production is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production intersection_of: GO:0008150 ! biological_process @@ -217833,61 +218539,6 @@ relationship: positively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 p created_by: bf creation_date: 2010-05-07T10:24:21Z -[Term] -id: GO:0035534 -name: chemokine (C-C motif) ligand 6 secretion -namespace: biological_process -def: "The regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:amm] -synonym: "CCL6 secretion" EXACT [] -is_a: GO:0090195 ! chemokine secretion -relationship: part_of GO:0035530 ! chemokine (C-C motif) ligand 6 production -created_by: bf -creation_date: 2010-05-07T10:28:11Z - -[Term] -id: GO:0035535 -name: regulation of chemokine (C-C motif) ligand 6 secretion -namespace: biological_process -def: "Any process that modulates the rate, frequency or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf] -synonym: "regulation of CCL6 secretion" EXACT [] -is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production -is_a: GO:0090196 ! regulation of chemokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion -relationship: regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion -created_by: bf -creation_date: 2010-05-07T10:29:40Z - -[Term] -id: GO:0035536 -name: negative regulation of chemokine (C-C motif) ligand 6 secretion -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf] -synonym: "negative regulation of CCL6 secretion" EXACT [] -is_a: GO:0035532 ! negative regulation of chemokine (C-C motif) ligand 6 production -is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion -is_a: GO:0090198 ! negative regulation of chemokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion -relationship: negatively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion -created_by: bf -creation_date: 2010-05-07T10:30:14Z - -[Term] -id: GO:0035537 -name: positive regulation of chemokine (C-C motif) ligand 6 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." [GOC:add, GOC:bf] -synonym: "positive regulation of CCL6 secretion" EXACT [] -is_a: GO:0035533 ! positive regulation of chemokine (C-C motif) ligand 6 production -is_a: GO:0035535 ! regulation of chemokine (C-C motif) ligand 6 secretion -is_a: GO:0090197 ! positive regulation of chemokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion -relationship: positively_regulates GO:0035534 ! chemokine (C-C motif) ligand 6 secretion -created_by: bf -creation_date: 2010-05-07T10:31:19Z - [Term] id: GO:0035538 name: carbohydrate response element binding @@ -217995,71 +218646,6 @@ relationship: part_of GO:0007399 ! nervous system development created_by: bf creation_date: 2010-05-11T01:53:33Z -[Term] -id: GO:0035546 -name: interferon-beta secretion -namespace: biological_process -def: "The regulated release of interferon-beta from a cell." [GOC:add, GOC:bf] -synonym: "IFN-beta secretion" EXACT [] -synonym: "IFNB secretion" EXACT [GOC:mah] -is_a: GO:0072641 ! type I interferon secretion -relationship: part_of GO:0032608 ! interferon-beta production -created_by: bf -creation_date: 2010-05-12T10:04:11Z - -[Term] -id: GO:0035547 -name: regulation of interferon-beta secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf] -synonym: "regulation of IFN-beta secretion" EXACT [] -is_a: GO:0032648 ! regulation of interferon-beta production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0035546 ! interferon-beta secretion -relationship: regulates GO:0035546 ! interferon-beta secretion -created_by: bf -creation_date: 2010-05-12T10:06:03Z - -[Term] -id: GO:0035548 -name: negative regulation of interferon-beta secretion -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf] -synonym: "down regulation of interferon-beta secretion" EXACT [] -synonym: "down-regulation of interferon-beta secretion" EXACT [] -synonym: "downregulation of interferon-beta secretion" EXACT [] -synonym: "inhibition of interferon-beta secretion" NARROW [] -synonym: "negative regulation of IFN-beta secretion" EXACT [] -is_a: GO:0032688 ! negative regulation of interferon-beta production -is_a: GO:0035547 ! regulation of interferon-beta secretion -is_a: GO:0050710 ! negative regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0035546 ! interferon-beta secretion -relationship: negatively_regulates GO:0035546 ! interferon-beta secretion -created_by: bf -creation_date: 2010-05-12T10:06:28Z - -[Term] -id: GO:0035549 -name: positive regulation of interferon-beta secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion." [GOC:add, GOC:bf] -synonym: "activation of interferon-beta secretion" NARROW [] -synonym: "positive regulation of IFN-beta secretion" EXACT [] -synonym: "stimulation of interferon-beta secretion" NARROW [] -synonym: "up regulation of interferon-beta secretion" EXACT [] -synonym: "up-regulation of interferon-beta secretion" EXACT [] -synonym: "upregulation of interferon-beta secretion" EXACT [] -is_a: GO:0032728 ! positive regulation of interferon-beta production -is_a: GO:0035547 ! regulation of interferon-beta secretion -is_a: GO:0050715 ! positive regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0035546 ! interferon-beta secretion -relationship: positively_regulates GO:0035546 ! interferon-beta secretion -created_by: bf -creation_date: 2010-05-12T10:06:50Z - [Term] id: GO:0035550 name: urease complex @@ -220347,6 +220933,7 @@ namespace: biological_process def: "The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:10639460] synonym: "migration in host through an epithelial cell layer" EXACT [GOC:bf] synonym: "migration of symbiont within host by transepithelial trafficking" EXACT [GOC:bf] +synonym: "transmigration of symbiont in host" RELATED [] is_a: GO:0044001 ! migration in host created_by: bf creation_date: 2011-03-24T10:20:03Z @@ -220713,7 +221300,7 @@ creation_date: 2011-04-06T10:45:15Z id: GO:0035790 name: platelet-derived growth factor receptor-alpha signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:yaf, PMID:10372961, PR:000002030] +def: "A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:yaf, PMID:10372961] synonym: "alphaPDGF receptor signaling pathway" EXACT [PMID:10372961] synonym: "PDGF receptor-alpha signaling pathway" EXACT [GOC:bf] synonym: "PDGFR-alpha signaling pathway" RELATED [GOC:bf] @@ -220726,7 +221313,7 @@ creation_date: 2011-04-06T10:55:16Z id: GO:0035791 name: platelet-derived growth factor receptor-beta signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961, PR:000002035] +def: "A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961] synonym: "betaPDGF receptor signaling pathway" EXACT [PMID:10372961] synonym: "PDGF receptor-beta signaling pathway" EXACT [GOC:bf] synonym: "PDGFR-beta signaling pathway" EXACT [GOC:bf] @@ -221854,16 +222441,18 @@ name: exochitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293, PMID:16298970, PMID:21390509] xref: MetaCyc:RXN-12309 +xref: RHEA:50672 is_a: GO:0004568 ! chitinase activity created_by: bf creation_date: 2011-06-08T11:13:58Z [Term] id: GO:0035886 -name: vascular smooth muscle cell differentiation +name: vascular associated smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954] synonym: "vascular associated smooth muscle cell differentiation" EXACT [CL:0000359] +synonym: "vascular smooth muscle cell differentiation" EXACT [] synonym: "VSMC differentiation" EXACT [PMID:16151017] is_a: GO:0051145 ! smooth muscle cell differentiation relationship: part_of GO:0001944 ! vasculature development @@ -221875,7 +222464,7 @@ id: GO:0035887 name: aortic smooth muscle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl] -is_a: GO:0035886 ! vascular smooth muscle cell differentiation +is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation created_by: bf creation_date: 2011-06-08T11:34:26Z @@ -222000,7 +222589,7 @@ creation_date: 2011-06-15T03:00:27Z id: GO:0035898 name: parathyroid hormone secretion namespace: biological_process -def: "The regulated release of parathyroid hormone into the circulatory system." [GOC:cjm, PMID:12171519, PMID:21164021, PR:000013429] +def: "The regulated release of parathyroid hormone into the circulatory system." [GOC:cjm, PMID:12171519, PMID:21164021] synonym: "parathormone secretion" EXACT [PR:000013429] synonym: "parathyrin secretion" EXACT [PR:000013429] synonym: "PTH secretion" EXACT [PMID:12171519, PR:000013429] @@ -222283,7 +222872,6 @@ name: flurbiprofen binding namespace: molecular_function def: "Interacting selectively and non-covalently with flurbiprofen." [GOC:BHF, GOC:rl] synonym: "2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0097159 ! organic cyclic compound binding created_by: bf @@ -222313,17 +222901,6 @@ is_a: GO:0017091 ! AU-rich element binding created_by: bf creation_date: 2011-07-19T09:30:18Z -[Term] -id: GO:0035926 -name: chemokine (C-C motif) ligand 2 secretion -namespace: biological_process -def: "The regulated release of chemokine (C-C motif) ligand 2 (CCL2) from a cell." [PMID:21501162] -synonym: "CCL2 secretion" EXACT [GOC:bf] -is_a: GO:0090195 ! chemokine secretion -relationship: part_of GO:0072567 ! chemokine (C-X-C motif) ligand 2 production -created_by: bf -creation_date: 2011-07-19T09:33:54Z - [Term] id: GO:0035927 name: RNA import into mitochondrion @@ -222508,7 +223085,6 @@ def: "The regulated release of estrone into the circulatory system." [GOC:sl, PM synonym: "3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [] synonym: "folliculin secretion" EXACT [] is_a: GO:0015850 ! organic hydroxy compound transport -is_a: GO:0015893 ! drug transport is_a: GO:0046879 ! hormone secretion is_a: GO:0140353 ! lipid export from cell created_by: bf @@ -222518,7 +223094,7 @@ creation_date: 2011-07-25T02:18:40Z id: GO:0035944 name: perforin production namespace: biological_process -def: "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000003466] +def: "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] is_a: GO:0002440 ! production of molecular mediator of immune response created_by: bf creation_date: 2011-07-27T11:44:21Z @@ -223146,8 +223722,6 @@ name: nitric oxide sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)." [GOC:kmv, PMID:21491957] synonym: "NO sensor activity" EXACT [] -is_a: GO:0008144 ! drug binding -is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0070026 ! nitric oxide binding is_a: GO:0140299 ! small molecule sensor activity relationship: part_of GO:0071731 ! response to nitric oxide @@ -223230,7 +223804,6 @@ xref: UniPathway:UPA00848 is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0051066 ! dihydrobiopterin metabolic process -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process created_by: bf creation_date: 2011-09-02T01:15:35Z @@ -223419,7 +223992,7 @@ creation_date: 2011-10-10T02:12:28Z id: GO:0036015 name: response to interleukin-3 namespace: biological_process -def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387] +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf] synonym: "response to IL-3" EXACT [GOC:bf] is_a: GO:0034097 ! response to cytokine created_by: bf @@ -223429,7 +224002,7 @@ creation_date: 2011-10-12T10:08:26Z id: GO:0036016 name: cellular response to interleukin-3 namespace: biological_process -def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387] +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf] synonym: "cellular response to IL-3" EXACT [GOC:bf] is_a: GO:0036015 ! response to interleukin-3 is_a: GO:0071345 ! cellular response to cytokine stimulus @@ -223440,7 +224013,7 @@ creation_date: 2011-10-12T10:09:10Z id: GO:0036017 name: response to erythropoietin namespace: biological_process -def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis." [GOC:yaf, PR:000007141] +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis." [GOC:yaf] is_a: GO:0034097 ! response to cytokine created_by: bf creation_date: 2011-10-12T10:11:04Z @@ -223449,7 +224022,7 @@ creation_date: 2011-10-12T10:11:04Z id: GO:0036018 name: cellular response to erythropoietin namespace: biological_process -def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus." [GOC:yaf, PR:000007141] +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus." [GOC:yaf] is_a: GO:0036017 ! response to erythropoietin is_a: GO:0071345 ! cellular response to cytokine stimulus created_by: bf @@ -223716,7 +224289,6 @@ synonym: "diferuloylmethane metabolic process" EXACT [GOC:obol] synonym: "diferuloylmethane metabolism" EXACT [GOC:obol] synonym: "turmeric yellow metabolic process" EXACT [GOC:obol] synonym: "turmeric yellow metabolism" EXACT [GOC:obol] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042180 ! cellular ketone metabolic process @@ -223743,11 +224315,9 @@ synonym: "turmeric yellow breakdown" EXACT [GOC:obol] synonym: "turmeric yellow catabolic process" EXACT [GOC:obol] synonym: "turmeric yellow catabolism" EXACT [GOC:obol] synonym: "turmeric yellow degradation" EXACT [GOC:obol] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0036039 ! curcumin metabolic process is_a: GO:0042182 ! ketone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901502 ! ether catabolic process created_by: bf creation_date: 2011-11-22T02:01:05Z @@ -223766,7 +224336,8 @@ creation_date: 2011-11-24T02:54:39Z id: GO:0036042 name: long-chain fatty acyl-CoA binding namespace: molecular_function -def: "Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [GOC:pm] +def: "Interacting selectively and non-covalently with a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [GOC:krc, GOC:pm] +synonym: "long-chain fatty acyl-coenyme A binding" EXACT [] is_a: GO:0000062 ! fatty-acyl-CoA binding created_by: bf creation_date: 2011-11-24T04:31:09Z @@ -223801,7 +224372,6 @@ def: "OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine t comment: This term was made obsolete because it accidentally reused an exisiting id. See replacement term GO:0044392. synonym: "lysine malonylation" EXACT [PMID:21908771] synonym: "peptidyl-lysine malonylation" EXACT [] -xref: RESID:AA0568 is_obsolete: true replaced_by: GO:0044392 created_by: bf @@ -224268,7 +224838,6 @@ synonym: "D-serine catabolism" EXACT [GOC:bf] synonym: "D-serine degradation" EXACT [GOC:bf] is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0019478 ! D-amino acid catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0070178 ! D-serine metabolic process created_by: bf creation_date: 2012-01-06T10:58:51Z @@ -224539,7 +225108,6 @@ synonym: "ALA metabolism" EXACT [CHEBI:27432] synonym: "alpha-linolenic acid metabolism" EXACT [GOC:bf] xref: Wikipedia:Linoleic_acid is_a: GO:0001676 ! long-chain fatty acid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process created_by: bf creation_date: 2012-02-15T10:16:42Z @@ -224609,7 +225177,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of a fatty- synonym: "fatty-acyl-CoA breakdown" EXACT [GOC:bf] synonym: "fatty-acyl-CoA catabolism" EXACT [GOC:bf] synonym: "fatty-acyl-CoA degradation" EXACT [GOC:bf] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process @@ -224695,7 +225262,7 @@ creation_date: 2012-02-20T02:53:51Z id: GO:0036122 name: BMP binding namespace: molecular_function -def: "Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951, PR:000000034] +def: "Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951] synonym: "bone morphogenetic protein binding" EXACT [GOC:bf] is_a: GO:0019955 ! cytokine binding created_by: bf @@ -224787,6 +225354,7 @@ synonym: "PGH2 9,11-endoperoxidase" EXACT [PMID:12664595] synonym: "PGH2 9-,11-endoperoxide reductase" EXACT [PMID:12432932] xref: KEGG_REACTION:R02264 xref: Reactome:R-HSA-2161549 "PGH2 is reduced to PGF2a by AKR1C3" +xref: RHEA:45312 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor relationship: part_of GO:0006693 ! prostaglandin metabolic process created_by: bf @@ -224802,6 +225370,7 @@ synonym: "prostaglandin 11-keto reductase" EXACT [PMID:7248318] xref: EC:1.1.1.188 xref: KEGG_REACTION:R02799 xref: Reactome:R-HSA-2161614 "PGD2 is reduced to 11-epi-PGF2a by AKRIC3" +xref: RHEA:45316 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor relationship: part_of GO:0006693 ! prostaglandin metabolic process created_by: bf @@ -224837,6 +225406,7 @@ comment: Note that the KEGG_REACTION:R05060 reaction does not stipulate the acce synonym: "NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity" EXACT [PMID:1632314] xref: KEGG_REACTION:R05060 xref: Reactome:R-HSA-2161732 "TXB2 is converted to 11dh-TXB2 by TXDH" +xref: RHEA:52312 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor created_by: bf creation_date: 2012-03-05T11:05:09Z @@ -224848,6 +225418,7 @@ namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)." [GOC:mw, PMID:11297515] synonym: "prostaglandin H2 degradation activity" RELATED [GOC:mw] xref: Reactome:R-HSA-2161613 "PGH2 is degraded to 12S-HHT and MDA by TBXAS1" +xref: RHEA:48644 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor created_by: bf creation_date: 2012-03-05T11:17:34Z @@ -225094,8 +225665,7 @@ creation_date: 2012-03-26T01:16:55Z id: GO:0036161 name: calcitonin secretion namespace: biological_process -def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm, PR:000027222] -is_a: GO:0015893 ! drug transport +def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm] is_a: GO:0030072 ! peptide hormone secretion created_by: bf creation_date: 2012-03-26T01:30:32Z @@ -225105,7 +225675,6 @@ id: GO:0036162 name: oxytocin secretion namespace: biological_process def: "The regulated release of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain, from a cell. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior." [GOC:cjm, Wikipedia:Oxytocin] -is_a: GO:0015893 ! drug transport is_a: GO:0030072 ! peptide hormone secretion created_by: bf creation_date: 2012-03-26T01:43:46Z @@ -225116,6 +225685,7 @@ name: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2." [GOC:mw, KEGG_REACTION:R06866, PMID:620805, PMID:7028108] xref: KEGG_REACTION:R06866 +xref: RHEA:44768 is_a: GO:0016831 ! carboxy-lyase activity created_by: bf creation_date: 2012-03-26T01:49:54Z @@ -225725,7 +226295,7 @@ creation_date: 2012-04-26T02:58:50Z id: GO:0036215 name: response to stem cell factor namespace: biological_process -def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PR:000009345] +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh] synonym: "response to hematopoietic growth factor KL" EXACT [PR:000009345] synonym: "response to KIT ligand" EXACT [PR:000009345] synonym: "response to SCF" EXACT [PR:000009345] @@ -225738,7 +226308,7 @@ creation_date: 2012-04-27T10:26:37Z id: GO:0036216 name: cellular response to stem cell factor stimulus namespace: biological_process -def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PMID:18787413, PMID:7520444, PR:000009345] +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PMID:18787413, PMID:7520444] synonym: "cellular response to hematopoietic growth factor KL" EXACT [PR:000009345] synonym: "cellular response to KIT ligand" EXACT [PR:000009345] synonym: "cellular response to KITLG" EXACT [PMID:18787413] @@ -225987,7 +226557,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of glutamat comment: In the catabolism of glutamate in mammals, succinate semialdehyde is converted to succinate (see GO:0006540). Plants can utilize an alternative route, converting succinic semialdehyde to 4-hydroxybutyrate using gamma-hydroxybutyrate dehydrogenase. synonym: "glutamate degradation to 4-hydroxybutyrate" EXACT [MetaCyc:PWY-4321] is_a: GO:0006538 ! glutamate catabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046459 ! short-chain fatty acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process relationship: has_part GO:0047577 ! 4-hydroxybutyrate dehydrogenase activity @@ -226012,12 +226581,14 @@ creation_date: 2012-05-23T02:28:33Z id: GO:0036243 name: succinate-semialdehyde dehydrogenase (NADP+) activity namespace: molecular_function -def: "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+." [EC:1.2.1.79, GOC:bf] +def: "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+." [GOC:bf, RHEA:13213] comment: This function is similar to EC:1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC:1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. synonym: "NADP-dependent succinate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.79] synonym: "succinate semialdehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.79] synonym: "succinic semialdehyde dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.79] synonym: "succinyl semialdehyde dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.79] +xref: EC:1.2.1.79 +xref: RHEA:13213 is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity created_by: bf creation_date: 2012-05-23T02:47:52Z @@ -226038,7 +226609,6 @@ name: cellular response to menadione namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [GOC:al, Wikipedia:Menadione] synonym: "cellular response to vitamin K3" EXACT [GOC:al] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901655 ! cellular response to ketone created_by: bf @@ -226100,11 +226670,12 @@ creation_date: 2012-05-31T03:09:09Z [Term] id: GO:0036251 -name: positive regulation of transcription from RNA polymerase II promoter in response to salt stress +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to salt stress namespace: biological_process -def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:al] -is_a: GO:0061393 ! positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress -is_a: GO:0061416 ! regulation of transcription from RNA polymerase II promoter in response to salt stress +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:al] +comment: This term was obsoleted because it represents a GO-CAM model. +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI +is_obsolete: true created_by: bf creation_date: 2012-06-12T11:38:22Z @@ -226127,7 +226698,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0036270 ! response to diuretic created_by: bf creation_date: 2012-06-15T01:05:35Z @@ -226136,7 +226706,6 @@ id: GO:0036254 name: cellular response to amiloride namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0036253 ! response to amiloride is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound @@ -226228,7 +226797,7 @@ creation_date: 2012-06-15T02:21:39Z id: GO:0036262 name: granulysin production namespace: biological_process -def: "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000008119] +def: "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] is_a: GO:0002440 ! production of molecular mediator of immune response created_by: bf creation_date: 2012-06-18T02:11:15Z @@ -226323,7 +226892,6 @@ subset: gocheck_do_not_manually_annotate synonym: "response to MPD" EXACT [CHEBI:6887] synonym: "response to MPH" EXACT [CHEBI:6887] synonym: "response to ritalin" EXACT [CHEBI:6887] -is_a: GO:0042493 ! response to drug is_a: GO:1901698 ! response to nitrogen compound created_by: bf creation_date: 2012-07-09T01:30:57Z @@ -226337,12 +226905,8 @@ comment: Note that this term is in the subset of terms that should not be used f subset: gocheck_do_not_manually_annotate synonym: "response to 2',2'-difluorodeoxycytidine" EXACT [CHEBI:175901] synonym: "response to 2'-deoxy-2',2'-difluorocytidine" EXACT [CHEBI:175901] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097327 ! response to antineoplastic agent -is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: bf creation_date: 2012-07-09T01:36:03Z @@ -226357,7 +226921,6 @@ subset: gocheck_do_not_manually_annotate synonym: "response to HMG-CoA reductase inhibitor" RELATED [CHEBI:35664] synonym: "response to hydroxymethylglutaryl-CoA reductase inhibitor" RELATED [CHEBI:35664] is_a: GO:0010033 ! response to organic substance -is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: bf creation_date: 2012-07-09T01:54:01Z @@ -226371,7 +226934,6 @@ comment: Note that this term is in the subset of terms that should not be used f subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: bf creation_date: 2012-07-09T02:02:26Z @@ -226385,10 +226947,7 @@ comment: Note that this term is in the subset of terms that should not be used f subset: gocheck_do_not_manually_annotate synonym: "response to 5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT [CHEBI:46345] synonym: "response to fluorouracil" EXACT [GOC:hp] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097327 ! response to antineoplastic agent -is_a: GO:0097329 ! response to antimetabolite created_by: bf creation_date: 2012-07-09T02:08:23Z @@ -226442,7 +227001,6 @@ name: cellular response to L-canavanine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group." [GOC:al] is_a: GO:0071230 ! cellular response to amino acid stimulus -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901354 ! response to L-canavanine created_by: bf creation_date: 2012-07-11T11:09:37Z @@ -226514,7 +227072,6 @@ subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:0071867 ! response to monoamine -is_a: GO:0097332 ! response to antipsychotic drug is_a: GO:1901654 ! response to ketone created_by: bf creation_date: 2012-07-16T05:01:29Z @@ -226528,7 +227085,6 @@ comment: Note that this term is in the subset of terms that should not be used f subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0061476 ! response to anticoagulant is_a: GO:1901700 ! response to oxygen-containing compound created_by: bf creation_date: 2012-07-16T05:03:56Z @@ -226766,12 +227322,10 @@ def: "Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to synonym: "annealing activity" BROAD [GOC:bf] synonym: "ATP-dependent DNA annealing activity" RELATED [GOC:sp] synonym: "nucleoside-triphosphatase activity involved in DNA annealing" EXACT [GOC:bf] -is_a: GO:0017111 ! nucleoside-triphosphatase activity is_a: GO:0097617 ! annealing activity -is_a: GO:0140097 ! catalytic activity, acting on DNA -intersection_of: GO:0017111 ! nucleoside-triphosphatase activity -intersection_of: part_of GO:0000733 ! DNA strand renaturation +relationship: has_part GO:0016887 ! ATPase activity relationship: part_of GO:0000733 ! DNA strand renaturation +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19669 xsd:anyURI created_by: bf creation_date: 2012-08-14T15:24:29Z @@ -226886,8 +227440,8 @@ creation_date: 2012-08-30T16:51:12Z id: GO:0036320 name: mating-type P-factor pheromone receptor activity namespace: molecular_function -def: "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [GOC:al, PMID:8314086, PMID:886120] -synonym: "P-factor mating pheromone receptor activity" EXACT [2] +def: "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [GOC:al, PMID:8314086] +synonym: "P-factor mating pheromone receptor activity" EXACT [] synonym: "P-factor receptor activity" EXACT [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity is_a: GO:0036318 ! peptide pheromone receptor activity @@ -226900,7 +227454,6 @@ name: ghrelin secretion namespace: biological_process def: "The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone." [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin] synonym: "pancreatic ghrelin secretion" NARROW [GOC:cjm] -is_a: GO:0015893 ! drug transport is_a: GO:0030072 ! peptide hormone secretion created_by: bf creation_date: 2012-09-04T14:16:43Z @@ -226919,7 +227472,7 @@ creation_date: 2012-09-04T14:39:03Z id: GO:0036323 name: vascular endothelial growth factor receptor-1 signaling pathway namespace: biological_process -def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007563, Wikipedia:FLT1, Wikipedia:VEGF_receptors] +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, Wikipedia:FLT1, Wikipedia:VEGF_receptors] synonym: "FLT1 signaling pathway" EXACT [GOC:uh, PR:000007563] synonym: "VEGFR-1 signaling pathway" EXACT [PR:000007563, Reactome:R-HSA-194311, Wikipedia:VEGF_receptors] synonym: "VEGFR1 signaling pathway" EXACT [Reactome:R-HSA-194311] @@ -226931,7 +227484,7 @@ creation_date: 2012-09-04T15:11:21Z id: GO:0036324 name: vascular endothelial growth factor receptor-2 signaling pathway namespace: biological_process -def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:12967471, PR:000002112, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors] +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:12967471, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors] synonym: "FLK-1 signaling pathway" EXACT [PR:000002112] synonym: "KDR signaling pathway" EXACT [GOC:uh, PR:000002112, Wikipedia:Kinase_insert_domain_receptor] synonym: "VEGFR-2 signaling pathway" EXACT [PR:000002112, Reactome:R-HSA-194310, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors] @@ -226944,7 +227497,7 @@ creation_date: 2012-09-04T15:15:40Z id: GO:0036325 name: vascular endothelial growth factor receptor-3 signaling pathway namespace: biological_process -def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007565, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3] +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3] synonym: "FLT4 signaling pathway" EXACT [GOC:uh, PR:000007565] synonym: "VEGFR-3 signaling pathway" EXACT [Reactome:R-HSA-194308, Wikipedia:VEGF_receptors] synonym: "VEGFR3 signaling pathway" EXACT [Reactome:R-HSA-194310, Wikipedia:VEGFR3] @@ -226956,8 +227509,8 @@ creation_date: 2012-09-04T15:25:13Z id: GO:0036326 name: VEGF-A-activated receptor activity namespace: molecular_function -def: "Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017284, Wikipedia:VEGF-A] -synonym: "vascular endothelial growth factor A-activated receptor activity" EXACT [GOC:bf, PR:000017284] +def: "Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, Wikipedia:VEGF-A] +synonym: "vascular endothelial growth factor A-activated receptor activity" EXACT [GOC:bf] is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity created_by: bf creation_date: 2012-09-04T15:33:19Z @@ -226966,7 +227519,7 @@ creation_date: 2012-09-04T15:33:19Z id: GO:0036327 name: VEGF-B-activated receptor activity namespace: molecular_function -def: "Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000003096, Wikipedia:VEGF-B] +def: "Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, Wikipedia:VEGF-B] synonym: "vascular endothelial growth factor B-activated receptor activity" EXACT [GOC:bf, PR:000003096] is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity created_by: bf @@ -226976,7 +227529,7 @@ creation_date: 2012-09-04T15:36:05Z id: GO:0036328 name: VEGF-C-activated receptor activity namespace: molecular_function -def: "Combining with vascular endothelial growth factor C (VEGF-C) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017285, Wikipedia:VEGF-C] +def: "Combining with vascular endothelial growth factor C (VEGF-C) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, Wikipedia:VEGF-C] synonym: "vascular endothelial growth factor C-activated receptor activity" EXACT [GOC:bf, PR:000017285] synonym: "VEGFC-activated receptor activity" EXACT [PR:000017285] is_a: GO:0005021 ! vascular endothelial growth factor-activated receptor activity @@ -226987,7 +227540,7 @@ creation_date: 2012-09-04T15:37:17Z id: GO:0036329 name: VEGF-D-activated receptor activity namespace: molecular_function -def: "Combining with vascular endothelial growth factor D (VEGF-D) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000007520, Wikipedia:VEGF-D] +def: "Combining with vascular endothelial growth factor D (VEGF-D) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, Wikipedia:VEGF-D] synonym: "C-fos induced growth factor receptor activity" EXACT [PR:000007520, Wikipedia:VEGF-D] synonym: "vascular endothelial growth factor D-activated receptor activity" EXACT [GOC:bf, PR:000007520] synonym: "VEGFD-activated receptor activity" EXACT [PR:000017285] @@ -227020,7 +227573,7 @@ creation_date: 2012-09-05T09:07:14Z id: GO:0036332 name: placental growth factor-activated receptor activity namespace: molecular_function -def: "Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:uh, PMID:12871269, PMID:7929268, PR:000012605, Wikipedia:Placental_growth_factor] +def: "Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:uh, PMID:12871269, PMID:7929268, Wikipedia:Placental_growth_factor] synonym: "placental growth factor receptor activity" EXACT [GOC:bf] synonym: "PlGF receptor activity" RELATED [PMID:12871269] synonym: "PlGF-activated receptor activity" EXACT [GOC:uh, PMID:12871269] @@ -227177,6 +227730,7 @@ def: "Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstit xref: EC:5.1.99.5 xref: KEGG_REACTION:R09704 xref: MetaCyc:RXN-9781 +xref: RHEA:46624 is_a: GO:0016854 ! racemase and epimerase activity created_by: bf creation_date: 2012-09-19T10:47:56Z @@ -227241,6 +227795,7 @@ name: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+." [GOC:crds, InterPro:IPR005903, MetaCyc:RXN-8787, PMID:8437569] xref: MetaCyc:RXN-8787 +xref: RHEA:19733 is_a: GO:0016491 ! oxidoreductase activity relationship: part_of GO:0030494 ! bacteriochlorophyll biosynthetic process created_by: bf @@ -227507,6 +228062,7 @@ xref: Reactome:R-HSA-9026927 "GGT hydrolyses RCTR1 to RCTR2" xref: Reactome:R-HSA-9035966 "Defective GGT1 does not hydrolyse GSH" xref: RHEA:28807 is_a: GO:0008242 ! omega peptidase activity +is_a: GO:0070003 ! threonine-type peptidase activity created_by: bf creation_date: 2013-05-07T09:58:07Z @@ -227559,12 +228115,10 @@ synonym: "1alpha,25-dihydroxycholecalciferol biosynthesis" BROAD [CHEBI:17823] synonym: "1alpha,25-dihydroxyvitamin D3 biosynthesis" BROAD [CHEBI:17823] synonym: "calcitriol biosynthesis from calciol" EXACT [GOC:bf] synonym: "vitamin D3 activation" EXACT [GOC:bf, PMID:20506379] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0042368 ! vitamin D biosynthetic process is_a: GO:0044108 ! cellular alcohol biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0070640 ! vitamin D3 metabolic process -is_a: GO:0120178 ! steroid hormone biosynthetic process created_by: bf creation_date: 2013-05-15T11:46:08Z @@ -227622,6 +228176,7 @@ synonym: "NADH-dependent flavin reductase activity" EXACT [EC:1.5.1.36] xref: EC:1.5.1.36 xref: KEGG_REACTION:R09662 xref: MetaCyc:1.5.1.36-RXN +xref: RHEA:31303 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor created_by: bf creation_date: 2013-05-23T11:23:09Z @@ -228164,10 +228719,9 @@ creation_date: 2013-09-16T13:02:43Z id: GO:0036426 name: ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP." [RHEA:28118] +def: "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP." [GOC:curators] xref: KEGG_REACTION:R07257 xref: MetaCyc:2.4.1.54-RXN -xref: RHEA:28118 is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity created_by: bf creation_date: 2013-09-16T13:21:01Z @@ -228176,8 +228730,8 @@ creation_date: 2013-09-16T13:21:01Z id: GO:0036427 name: all-trans-undecaprenyl-phosphate mannosyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [RHEA:12784] -xref: RHEA:12784 +def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [RHEA:28118] +xref: RHEA:28118 is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity created_by: bf creation_date: 2013-09-16T13:23:06Z @@ -228488,71 +229042,12 @@ creation_date: 2013-12-09T13:04:09Z id: GO:0036458 name: hepatocyte growth factor binding namespace: molecular_function -def: "Interacting selectively and non-covalently with a hepatocyte growth factor." [PR:000008534] +def: "Interacting selectively and non-covalently with a hepatocyte growth factor." [GOC:curators] synonym: "HGF binding" EXACT [PR:000008534] is_a: GO:0019838 ! growth factor binding created_by: bf creation_date: 2013-12-09T14:07:20Z -[Term] -id: GO:0036459 -name: thiol-dependent ubiquitinyl hydrolase activity -namespace: molecular_function -def: "Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin." [EC:3.4.19.12, GOC:bf, GOC:ka] -comment: 20160208: Renamed to thiol-dependent ubiquitinyl hydrolase activity -synonym: "ubiquitin C-terminal hydrolase" EXACT [EC:3.4.19.12] -synonym: "ubiquitinyl hydrolase 1 activity" EXACT [EC:3.4.19.12] -synonym: "ubiquitinyl hydrolase activity" BROAD [] -xref: EC:3.4.19.12 -xref: Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2" -xref: Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains" -xref: Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2" -xref: Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN" -xref: Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4" -xref: Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53" -xref: Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B" -xref: Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin" -xref: Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A" -xref: Reactome:R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58" -xref: Reactome:R-HSA-5690196 "USP8 deubiquitinates RNF128" -xref: Reactome:R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts" -xref: Reactome:R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1" -xref: Reactome:R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex" -xref: Reactome:R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A" -xref: Reactome:R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1" -xref: Reactome:R-HSA-5696564 "USP25 deubiquitinates DDX58" -xref: Reactome:R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1" -xref: Reactome:R-HSA-5696605 "USP12, USP26 deubiquitinate AR" -xref: Reactome:R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG" -xref: Reactome:R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins" -xref: Reactome:R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC" -xref: Reactome:R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB" -xref: Reactome:R-HSA-5696947 "USP47 deubiquitinates POLB" -xref: Reactome:R-HSA-5696958 "USP44 deubiquitinates CDC20" -xref: Reactome:R-HSA-5696960 "USP49 deubiquitinates H2B" -xref: Reactome:R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2" -xref: Reactome:R-HSA-5696997 "USP24 deubiquitinates DDB2" -xref: Reactome:R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2" -xref: Reactome:R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1" -xref: Reactome:R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10" -xref: Reactome:R-HSA-6781814 "USP19 deubiquitinates RNF123" -xref: Reactome:R-HSA-6781897 "USP11 deubiquitinates NFKBIA" -xref: Reactome:R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR" -xref: Reactome:R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS" -xref: Reactome:R-HSA-6782820 "USP17 deubiquitinates SUDS3" -xref: Reactome:R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33" -xref: Reactome:R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4" -xref: Reactome:R-HSA-8862184 "USP48 cleaves polyubiquitin" -xref: Reactome:R-HSA-8865182 "OTUD7A hydrolyses K11diUb" -xref: Reactome:R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6" -xref: Reactome:R-HSA-8873946 "OTUD3 deubiquitinates PTEN" -xref: Reactome:R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin" -xref: Reactome:R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin" -is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity -is_a: GO:0101005 ! ubiquitinyl hydrolase activity -created_by: bf -creation_date: 2013-12-19T09:39:38Z - [Term] id: GO:0036460 name: cellular response to cell envelope stress @@ -229039,7 +229534,7 @@ creation_date: 2015-02-05T13:12:12Z id: GO:0036499 name: PERK-mediated unfolded protein response namespace: biological_process -def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210] +def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210, PMID:27629041] synonym: "EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255] synonym: "endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:bf] synonym: "eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response" RELATED [HGNC:3255] @@ -229050,6 +229545,7 @@ synonym: "PKR-like ER kinase signal transduction" EXACT [PMID:22013210] synonym: "UPR signaling by PERK stress sensor" EXACT [GOC:bf] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response +is_a: GO:0140467 ! integrated stress response signaling created_by: bf creation_date: 2015-02-05T13:17:43Z @@ -229129,7 +229625,7 @@ creation_date: 2015-05-21T10:05:06Z id: GO:0036505 name: prosaposin receptor activity namespace: molecular_function -def: "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)." [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493, PR:000031300] +def: "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)." [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493] synonym: "prosaposin-activated receptor activity" EXACT [GOC:bf] is_a: GO:0004930 ! G protein-coupled receptor activity created_by: bf @@ -229370,8 +229866,11 @@ creation_date: 2016-06-06T14:53:54Z id: GO:0036524 name: protein deglycase activity namespace: molecular_function -def: "Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein." [GOC:bf, GOC:PARL, MetaCyc:RXN-17630, MetaCyc:RXN-17632, MetaCyc:RXN-17634, PMID:14568004, PMID:25416785, PMID:26873906, RHEA:49548, RHEA:49552, RHEA:49556] +def: "Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785, PMID:26873906] synonym: "protein deglycating enzyme" RELATED [PMID:26873906] +xref: MetaCyc:RXN-17630 +xref: MetaCyc:RXN-17632 +xref: MetaCyc:RXN-17634 is_a: GO:0016836 ! hydro-lyase activity is_a: GO:0140096 ! catalytic activity, acting on a protein relationship: part_of GO:0036525 ! protein deglycation @@ -229763,6 +230262,8 @@ synonym: "endocytic receptor activity" NARROW [GOC:signaling, ISBN:0123645387, P synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in receptor-mediated endocytosis" NARROW [GOC:bf] synonym: "transport receptor activity" BROAD [GOC:signaling] +xref: Reactome:R-HSA-3000122 "CD320 transports extracellular TCII:Cbl to endosome" +xref: Reactome:R-HSA-350168 "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D" is_a: GO:0003674 ! molecular_function relationship: has_part GO:0060090 ! molecular adaptor activity relationship: part_of GO:0006897 ! endocytosis @@ -229773,7 +230274,7 @@ creation_date: 2011-08-01T02:50:45Z id: GO:0038025 name: reelin receptor activity namespace: molecular_function -def: "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879] +def: "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:12827279, PMID:20223215] synonym: "reeler receptor activity" EXACT [PR:000013879] is_a: GO:0004888 ! transmembrane signaling receptor activity relationship: part_of GO:0038026 ! reelin-mediated signaling pathway @@ -229784,7 +230285,7 @@ creation_date: 2011-08-02T12:01:25Z id: GO:0038026 name: reelin-mediated signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879] +def: "A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12827279, PMID:20223215] synonym: "reeler-mediated signaling pathway" EXACT [GOC:bf, PR:000013879] synonym: "reelin-mediated signal transduction pathway" EXACT [GOC:bf] synonym: "reelin-mediated signalling pathway" EXACT [GOC:bf] @@ -229991,7 +230492,7 @@ creation_date: 2011-11-02T04:52:24Z id: GO:0038043 name: interleukin-5-mediated signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:pg, GOC:signaling, PR:000001392] +def: "A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] synonym: "IL-5-mediated signaling pathway" EXACT [GOC:bf] synonym: "interleukin-5-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0019221 ! cytokine-mediated signaling pathway @@ -230078,7 +230579,7 @@ creation_date: 2011-11-29T04:29:42Z id: GO:0038055 name: BMP secretion namespace: biological_process -def: "The controlled release of a member of the BMP family of proteins from a cell." [GOC:sart, PR:000000034] +def: "The controlled release of a member of the BMP family of proteins from a cell." [GOC:sart] synonym: "BMP protein secretion" EXACT [GOC:bf] synonym: "bone morphogenetic protein secretion" EXACT [GOC:bf] is_a: GO:0009306 ! protein secretion @@ -230105,7 +230606,7 @@ creation_date: 2011-12-19T10:55:47Z id: GO:0038057 name: TNFSF11 binding namespace: molecular_function -def: "Interacting selectively and non-covalently with tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family." [GOC:cjm, PR:000002107] +def: "Interacting selectively and non-covalently with tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family." [GOC:cjm] synonym: "CD254 binding" EXACT [GOC:sl, PR:000002107] synonym: "ODF binding" EXACT [GOC:sl, PR:000002107] synonym: "OPGL binding" EXACT [GOC:sl, PR:000002107] @@ -230126,7 +230627,7 @@ creation_date: 2012-01-04T03:25:59Z id: GO:0038058 name: TNFSF11 receptor activity namespace: molecular_function -def: "Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function." [GOC:bf, GOC:cjm, PR:000002107] +def: "Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function." [GOC:bf, GOC:cjm] synonym: "RANKL receptor activity" EXACT [PR:000002107, Wikipedia:RANKL] synonym: "tumor necrosis factor ligand superfamily member 11 receptor activity" EXACT [PR:000002107, Wikipedia:RANKL] is_a: GO:0005031 ! tumor necrosis factor-activated receptor activity @@ -230456,7 +230957,7 @@ creation_date: 2012-02-01T02:14:18Z id: GO:0038084 name: vascular endothelial growth factor signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285] +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632] comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'. synonym: "vascular endothelial growth factor signalling pathway" EXACT [GOC:bf] synonym: "VEGF signaling" EXACT [GOC:bf] @@ -230470,7 +230971,7 @@ creation_date: 2012-02-01T02:27:32Z id: GO:0038085 name: vascular endothelial growth factor binding namespace: molecular_function -def: "Interacting selectively and non-covalently with a vascular endothelial growth factor." [PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285] +def: "Interacting selectively and non-covalently with a vascular endothelial growth factor." [PMID:17470632] synonym: "VEGF binding" EXACT [GOC:bf] is_a: GO:0019838 ! growth factor binding created_by: bf @@ -230526,7 +231027,7 @@ creation_date: 2012-02-01T03:10:16Z id: GO:0038089 name: positive regulation of cell migration by vascular endothelial growth factor signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PR:000003096, PR:000017284, PR:000017285] +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling] synonym: "positive regulation of cell migration by vascular endothelial growth factor signalling pathway" EXACT [GOC:mah] synonym: "positive regulation of cell migration by VEGF signaling pathway" EXACT [GOC:bf] synonym: "VEGF-A-induced cell migration" NARROW [PMID:17470632] @@ -230671,7 +231172,7 @@ creation_date: 2012-02-17T11:16:40Z id: GO:0038100 name: nodal binding namespace: molecular_function -def: "Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily." [GOC:bf, PMID:20629020, PR:000000105] +def: "Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily." [GOC:bf, PMID:20629020] is_a: GO:0005515 ! protein binding property_value: RO:0002161 NCBITaxon:4751 created_by: bf @@ -230857,9 +231358,9 @@ creation_date: 2012-03-22T10:21:01Z id: GO:0038115 name: chemokine (C-C motif) ligand 19 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001991] +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845] comment: The C-C chemokine CCL19 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL19-activated CCR7 signaling pathway ; GO:0038119'. -synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203] +synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845] synonym: "CCL19-mediated signaling pathway" EXACT [PMID:15059845] synonym: "chemokine (C-C motif) ligand 19 signalling pathway" EXACT [GOC:mah] is_a: GO:0070098 ! chemokine-mediated signaling pathway @@ -230870,7 +231371,7 @@ creation_date: 2012-03-22T11:28:32Z id: GO:0038116 name: chemokine (C-C motif) ligand 21 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001993] +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845] comment: The C-C chemokine CCL21 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203] synonym: "CCL21-mediated signaling pathway" EXACT [PMID:15059845] @@ -230883,7 +231384,7 @@ creation_date: 2012-03-22T11:30:47Z id: GO:0038117 name: C-C motif chemokine 19 receptor activity namespace: molecular_function -def: "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001991] +def: "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845] synonym: "CCL19 receptor activity" RELATED [PMID:15059845] is_a: GO:0016493 ! C-C chemokine receptor activity relationship: has_part GO:0035757 ! chemokine (C-C motif) ligand 19 binding @@ -230895,10 +231396,10 @@ creation_date: 2012-03-22T11:59:10Z id: GO:0038118 name: C-C chemokine receptor CCR7 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:15059845, PMID:15778365, PR:000001203] +def: "A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:15059845, PMID:15778365] comment: This term was created to show the binding of cytokines to multiple receptor types, and vice-versa. Known agonists of chemokine receptor type 7 (CCR7) are C-C chemokines CCL19 and CCL21. Consider instead annotating to one of the child terms 'CCL19-activated CCR7 signaling pathway ; GO:0038119' and/or 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. synonym: "C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:mah] -synonym: "CCR7 signaling pathway" RELATED [PR:000001203] +synonym: "CCR7 signaling pathway" RELATED [] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: bf creation_date: 2012-03-22T11:43:57Z @@ -230907,7 +231408,7 @@ creation_date: 2012-03-22T11:43:57Z id: GO:0038119 name: CCL19-activated CCR7 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203] +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845] synonym: "CCL19-activated CCR7 signalling pathway" EXACT [GOC:mah] is_a: GO:0038115 ! chemokine (C-C motif) ligand 19 signaling pathway is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway @@ -230918,7 +231419,7 @@ creation_date: 2012-03-22T11:47:24Z id: GO:0038120 name: CCL21-activated CCR7 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203] +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845] synonym: "CCL21-activated CCR7 signalling pathway" EXACT [GOC:mah] is_a: GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway @@ -230929,8 +231430,8 @@ creation_date: 2012-03-22T11:47:24Z id: GO:0038121 name: C-C motif chemokine 21 receptor activity namespace: molecular_function -def: "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001993] -synonym: "CCL21 receptor activity" RELATED [PMID:15059845, PR:000001993] +def: "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845] +synonym: "CCL21 receptor activity" RELATED [PMID:15059845] is_a: GO:0016493 ! C-C chemokine receptor activity relationship: has_part GO:0035758 ! chemokine (C-C motif) ligand 21 binding relationship: part_of GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway @@ -230941,7 +231442,7 @@ creation_date: 2012-03-22T01:28:06Z id: GO:0038122 name: C-C motif chemokine 5 receptor activity namespace: molecular_function -def: "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PR:000002094] +def: "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling] synonym: "CCL5 receptor activity" EXACT [PR:000002094] synonym: "RANTES receptor activity" EXACT [GOC:bf] synonym: "small inducible cytokine A5 receptor activity" EXACT [PR:000002094] @@ -230977,7 +231478,7 @@ creation_date: 2012-03-23T10:29:09Z id: GO:0038127 name: ERBB signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000001812, Wikipedia:ErbB] +def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, Wikipedia:ErbB] synonym: "EGF receptor family signaling pathway" EXACT [PMID:11597398] synonym: "EGFR family signaling pathway" RELATED [PMID:11597398] synonym: "ErbB signaling" EXACT [PMID:20933094, Wikipedia:ErbB] @@ -230990,7 +231491,7 @@ creation_date: 2012-03-30T09:23:01Z id: GO:0038128 name: ERBB2 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair." [GOC:jc, PMID:16460914, PR:000002082, Reactome:R-HSA-1227986] +def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair." [GOC:jc, PMID:16460914, Reactome:R-HSA-1227986] synonym: "ERBB2 signalling pathway" EXACT [GOC:mah] synonym: "HER2 signaling pathway" EXACT [PR:000002082] synonym: "NEU signaling" EXACT [Reactome:R-HSA-1227986] @@ -231003,7 +231504,7 @@ creation_date: 2012-03-30T10:05:12Z id: GO:0038129 name: ERBB3 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission." [GOC:jc, PMID:16460914, PR:000007159, Reactome:R-HSA-1247497] +def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission." [GOC:jc, PMID:16460914, Reactome:R-HSA-1247497] synonym: "ERBB3 signalling pathway" EXACT [GOC:mah] synonym: "HER3 signaling pathway" EXACT [PR:000007159] synonym: "receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [PR:000007159] @@ -231015,7 +231516,7 @@ creation_date: 2012-03-30T10:42:28Z id: GO:0038130 name: ERBB4 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000007160, Reactome:R-HSA-1236394] +def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, Reactome:R-HSA-1236394] synonym: "ERBB4 signalling pathway" EXACT [GOC:mah] synonym: "HER4 signaling pathway" EXACT [PR:000007160] synonym: "receptor tyrosine-protein kinase erbB-4 signaling pathway" EXACT [PR:000007160] @@ -231188,7 +231689,7 @@ creation_date: 2012-03-30T02:24:01Z id: GO:0038145 name: macrophage colony-stimulating factor signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, GOC:uh, PMID:12138890, PR:000005930, Wikipedia:Macrophage_colony-stimulating_factor] +def: "A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, GOC:uh, PMID:12138890, Wikipedia:Macrophage_colony-stimulating_factor] synonym: "M-CSF signaling pathway" EXACT [PMID:12138890] synonym: "macrophage colony-stimulating factor signalling pathway" EXACT [GOC:bf] is_a: GO:0019221 ! cytokine-mediated signaling pathway @@ -231200,7 +231701,7 @@ creation_date: 2012-04-27T11:04:18Z id: GO:0038146 name: chemokine (C-X-C motif) ligand 12 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000006066, Wikipedia:Stromal_cell-derived_factor-1] +def: "A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, Wikipedia:Stromal_cell-derived_factor-1] synonym: "CXCL12 signaling pathway" EXACT [GOC:bf] synonym: "CXCL12-activated CXCR7 signaling pathway" NARROW [GOC:bf] synonym: "SDF1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066] @@ -231228,7 +231729,7 @@ creation_date: 2012-05-11T11:32:53Z id: GO:0038148 name: chemokine (C-C motif) ligand 2 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000002122, Wikipedia:CCL2] +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, Wikipedia:CCL2] synonym: "CCL2 signaling pathway" EXACT [GOC:bf] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: bf @@ -231249,7 +231750,7 @@ creation_date: 2012-05-11T11:37:16Z id: GO:0038150 name: C-C chemokine receptor CCR2 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001199] +def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "C-C chemokine receptor type 2 signaling pathway" EXACT [PR:000001199] is_a: GO:0070098 ! chemokine-mediated signaling pathway created_by: bf @@ -231270,7 +231771,7 @@ creation_date: 2012-05-11T11:41:58Z id: GO:0038152 name: C-C chemokine receptor CCR4 signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001200] +def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] synonym: "C-C chemokine receptor type 4 signaling pathway" EXACT [PR:000001200] synonym: "chemokine receptor CCR4 signaling pathway" EXACT [GOC:bf] is_a: GO:0070098 ! chemokine-mediated signaling pathway @@ -231468,7 +231969,7 @@ creation_date: 2012-05-15T12:01:09Z id: GO:0038169 name: somatostatin receptor signaling pathway namespace: biological_process -def: "The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:18006219, PMID:8769369, PR:000001555] +def: "The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:18006219, PMID:8769369] comment: In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'. synonym: "SST receptor signaling pathway" EXACT [GOC:bf] synonym: "SSTR signaling pathway" RELATED [GOC:bf] @@ -231508,7 +232009,7 @@ creation_date: 2012-06-12T10:47:53Z id: GO:0038172 name: interleukin-33-mediated signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001389] +def: "A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling] synonym: "IL-33-mediated signaling pathway" EXACT [GOC:bf] synonym: "IL33 signaling pathway" EXACT [PR:000001389] synonym: "interleukin-33 signaling pathway" RELATED [GOC:jc] @@ -231521,7 +232022,7 @@ creation_date: 2012-06-12T10:57:35Z id: GO:0038173 name: interleukin-17A-mediated signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001138] +def: "A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling] synonym: "IL-17A-mediated signaling pathway" EXACT [GOC:bf] synonym: "IL17A signaling pathway" EXACT [PR:000001138, Wikipedia:IL17A] synonym: "IL17a signaling pathway" EXACT [GOC:jc] @@ -231535,7 +232036,7 @@ creation_date: 2012-06-12T10:59:01Z id: GO:0038174 name: interleukin-17A receptor activity namespace: molecular_function -def: "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:jc, GOC:signaling, PR:000001138] +def: "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:jc, GOC:signaling] is_a: GO:0030368 ! interleukin-17 receptor activity relationship: part_of GO:0038173 ! interleukin-17A-mediated signaling pathway created_by: bf @@ -231592,7 +232093,7 @@ creation_date: 2012-09-21T10:55:00Z id: GO:0038179 name: neurotrophin signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, PR:000021998, Wikipedia:Neurotrophin] +def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, Wikipedia:Neurotrophin] comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors. synonym: "neurotrophin receptor signaling pathway" EXACT [PMID:22333586] is_a: GO:0007166 ! cell surface receptor signaling pathway @@ -231604,7 +232105,7 @@ creation_date: 2013-03-27T17:22:44Z id: GO:0038180 name: nerve growth factor signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:11520933, PR:000011194, Wikipedia:Nerve_growth_factor] +def: "A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:11520933, Wikipedia:Nerve_growth_factor] comment: Nerve growth factor (NGF) binds at least two classes of receptors: the p75 LNGFR (low-affinity nerve growth factor receptor) and TrkA, a transmembrane tyrosine kinase. synonym: "nerve growth factor signalling pathway" EXACT [GOC:bf] synonym: "NGF signaling pathway" EXACT [PR:000011194, Wikipedia:Nerve_growth_factor] @@ -233244,12 +233745,16 @@ creation_date: 2012-05-02T03:04:55Z [Term] id: GO:0039585 -name: PKR signal transduction +name: PKR-mediated signaling namespace: biological_process -def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR, an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation." [PMID:21204021, PMID:22102852, PMID:9843495, VZ:1576] +def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK3), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation." [PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576] +synonym: "EIF2AK3 signal transduction" EXACT [] +synonym: "EIF2AK3/PERK signaling" EXACT [] +synonym: "PKR signal transduction" EXACT [] synonym: "PKR signaling pathway" EXACT [PMID:22102852] synonym: "signaling through PKR" EXACT [GOC:bf] is_a: GO:0035556 ! intracellular signal transduction +is_a: GO:0140467 ! integrated stress response signaling created_by: bf creation_date: 2012-05-02T04:15:10Z @@ -234671,7 +235176,7 @@ creation_date: 2013-12-19T13:21:45Z id: GO:0039713 name: viral factory namespace: cellular_component -def: "An intracellular compartment in a host cell which increases the efficiency of viral replication and/or assembly, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments." [PMID:22440839, VZ:1951] +def: "An intracellular compartment in a host cell which increases the efficiency of viral replication, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments." [PMID:22440839, VZ:1951] synonym: "virus factory" EXACT [PMID:22440839] xref: VZ:1951 "Viral factories" is_a: GO:0033643 ! host cell part @@ -234777,7 +235282,7 @@ creation_date: 2014-01-06T11:39:58Z id: GO:0039723 name: suppression by virus of host TBK1 activity namespace: biological_process -def: "Any process in which a virus stops, prevents, or reduces the activity of the host serine/threonine kinase TBK1." [PR:000001779, UniProtKB-KW:KW-1223] +def: "Any process in which a virus stops, prevents, or reduces the activity of the host serine/threonine kinase TBK1." [UniProtKB-KW:KW-1223] comment: When TBK1 acts as part of a TBK1-IKBKE-DDX3 complex, consider also annotating to: suppression by virus of host TBK1-IKBKE-DDX3 complex activity ; GO:0039659. synonym: "inhibition of host TBK1 by virus" EXACT [UniProtKB-KW:KW-1223] is_a: GO:0039503 ! suppression by virus of host innate immune response @@ -234789,7 +235294,7 @@ creation_date: 2014-01-06T12:04:44Z id: GO:0039724 name: suppression by virus of host IKBKE activity namespace: biological_process -def: "Any process in which a virus stops, prevents, or reduces the activity of the host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [PR:000001778, UniProtKB-KW:KW-1224] +def: "Any process in which a virus stops, prevents, or reduces the activity of the host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [UniProtKB-KW:KW-1224] comment: When IKBKE acts as part of a TBK1-IKBKE-DDX3 complex, consider also annotating to: suppression by virus of host TBK1-IKBKE-DDX3 complex activity ; GO:0039659. synonym: "inhibition of host IKBKE by virus" EXACT [UniProtKB-KW:KW-1224] is_a: GO:0039503 ! suppression by virus of host innate immune response @@ -235484,8 +235989,6 @@ synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [ synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [EC:3.4.24.72] synonym: "fibrinolytic proteinase activity" EXACT [EC:3.4.24.72] synonym: "fibrolase activity" EXACT [] -xref: EC:3.4.24.72 -xref: MetaCyc:3.4.24.72-RXN is_obsolete: true replaced_by: GO:0004222 @@ -235508,7 +236011,6 @@ comment: This term was made obsolete because it represents a regulator of a non- synonym: "ACE inhibitor" EXACT [] synonym: "angiotensin-converting enzyme inhibitor activity" EXACT [] synonym: "peptidyl dipeptidase A inhibitor" EXACT [] -xref: Wikipedia:ACE_inhibitor is_obsolete: true replaced_by: GO:0060422 @@ -235663,7 +236165,6 @@ synonym: "W-molybdopterin cofactor anabolism" EXACT [] synonym: "W-molybdopterin cofactor biosynthesis" EXACT [] synonym: "W-molybdopterin cofactor formation" EXACT [] synonym: "W-molybdopterin cofactor synthesis" EXACT [] -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process @@ -236084,35 +236585,6 @@ is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0042107 ! cytokine metabolic process relationship: part_of GO:0001816 ! cytokine production -[Term] -id: GO:0042090 -name: interleukin-12 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] -synonym: "IL-12 biosynthesis" EXACT [] -synonym: "IL-12 biosynthetic process" EXACT [] -synonym: "interleukin-12 anabolism" EXACT [] -synonym: "interleukin-12 biosynthesis" EXACT [] -synonym: "interleukin-12 formation" EXACT [] -synonym: "interleukin-12 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -relationship: part_of GO:0032615 ! interleukin-12 production - -[Term] -id: GO:0042091 -name: interleukin-10 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] -synonym: "IL-10 biosynthesis" EXACT [] -synonym: "IL-10 biosynthetic process" EXACT [] -synonym: "interleukin-10 anabolism" EXACT [] -synonym: "interleukin-10 biosynthesis" EXACT [] -synonym: "interleukin-10 formation" EXACT [] -synonym: "interleukin-10 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032613 ! interleukin-10 production - [Term] id: GO:0042092 name: type 2 immune response @@ -236131,37 +236603,6 @@ synonym: "helper T cell differentiation" EXACT [CL:0000912] synonym: "T-helper cell development" RELATED [GOC:add] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response -[Term] -id: GO:0042094 -name: interleukin-2 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] -synonym: "IL-2 biosynthesis" EXACT [] -synonym: "IL-2 biosynthetic process" EXACT [] -synonym: "interleukin-2 anabolism" EXACT [] -synonym: "interleukin-2 biosynthesis" EXACT [] -synonym: "interleukin-2 formation" EXACT [] -synonym: "interleukin-2 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032623 ! interleukin-2 production - -[Term] -id: GO:0042095 -name: interferon-gamma biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:go_curators, PR:000000017] -synonym: "IFN-gamma biosynthesis" EXACT [] -synonym: "IFN-gamma biosynthetic process" EXACT [] -synonym: "interferon type II biosynthesis" BROAD [] -synonym: "interferon type II biosynthetic process" BROAD [] -synonym: "interferon-gamma anabolism" EXACT [] -synonym: "interferon-gamma biosynthesis" EXACT [] -synonym: "interferon-gamma formation" EXACT [] -synonym: "interferon-gamma synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -relationship: part_of GO:0032609 ! interferon-gamma production - [Term] id: GO:0042096 name: obsolete alpha-beta T cell receptor activity @@ -236174,22 +236615,6 @@ consider: GO:0032394 consider: GO:0032395 consider: GO:0042605 -[Term] -id: GO:0042097 -name: interleukin-4 biosynthetic process -namespace: biological_process -alt_id: GO:0042224 -def: "The chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] -synonym: "IL-4 biosynthesis" EXACT [] -synonym: "IL-4 biosynthetic process" EXACT [] -synonym: "interleukin-4 anabolism" EXACT [] -synonym: "interleukin-4 biosynthesis" EXACT [] -synonym: "interleukin-4 formation" EXACT [] -synonym: "interleukin-4 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032633 ! interleukin-4 production - [Term] id: GO:0042098 name: T cell proliferation @@ -236430,7 +236855,6 @@ def: "The chemical reactions and pathways involving alginic acid, a hydrophilic synonym: "alginate metabolic process" EXACT [] synonym: "alginate metabolism" EXACT [] synonym: "alginic acid metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process @@ -236460,7 +236884,6 @@ synonym: "alginic acid breakdown" EXACT [] synonym: "alginic acid catabolism" EXACT [] synonym: "alginic acid degradation" EXACT [] is_a: GO:0042120 ! alginic acid metabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process @@ -236868,9 +237291,7 @@ id: GO:0042166 name: acetylcholine binding namespace: molecular_function def: "Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] -is_a: GO:0008144 ! drug binding is_a: GO:0042165 ! neurotransmitter binding -is_a: GO:0042562 ! hormone binding is_a: GO:0043169 ! cation binding [Term] @@ -237069,8 +237490,6 @@ synonym: "formate degradation" EXACT [] synonym: "formic acid catabolic process" EXACT [] synonym: "formic acid catabolism" EXACT [] is_a: GO:0015942 ! formate metabolic process -is_a: GO:0017001 ! antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] @@ -237139,7 +237558,6 @@ synonym: "DDT catabolism" EXACT [] is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046701 ! insecticide catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -237171,7 +237589,6 @@ synonym: "vanillin catabolism" EXACT [] synonym: "vanillin degradation" EXACT [] is_a: GO:0018982 ! vanillin metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:1901502 ! ether catabolic process @@ -237289,7 +237706,6 @@ def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a tri synonym: "cyromazine metabolic process" EXACT [] synonym: "cyromazine metabolism" EXACT [] synonym: "N-cyclopropylmelamine metabolism" EXACT [] -is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0018965 ! s-triazine compound metabolic process [Term] @@ -237305,8 +237721,6 @@ synonym: "N-cyclopropylmelamine degradation" EXACT [] xref: UM-BBD_pathwayID:cpm is_a: GO:0042201 ! N-cyclopropylmelamine metabolic process is_a: GO:0042204 ! s-triazine compound catabolic process -is_a: GO:0046701 ! insecticide catabolic process -is_a: GO:0051410 ! detoxification of nitrogen compound [Term] id: GO:0042203 @@ -237318,7 +237732,6 @@ synonym: "toluene catabolism" EXACT [] synonym: "toluene degradation" EXACT [] is_a: GO:0018970 ! toluene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] @@ -237441,7 +237854,6 @@ def: "The chemical reactions and pathways involving cresol, a mixture of the aro synonym: "cresol metabolism" EXACT [] synonym: "hydroxytoluene metabolic process" EXACT [] synonym: "hydroxytoluene metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process @@ -237491,7 +237903,6 @@ xref: UM-BBD_pathwayID:phe is_a: GO:0018955 ! phenanthrene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] @@ -237541,10 +237952,8 @@ id: GO:0042220 name: response to cocaine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:ef, GOC:jl] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid -is_a: GO:0072347 ! response to anesthetic is_a: GO:1901700 ! response to oxygen-containing compound [Term] @@ -237564,289 +237973,6 @@ synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] is_a: GO:0050896 ! response to stimulus -[Term] -id: GO:0042222 -name: interleukin-1 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen." [GOC:jl, ISBN:0198506732] -synonym: "IL-1 biosynthesis" EXACT [] -synonym: "IL-1 biosynthetic process" EXACT [] -synonym: "interleukin-1 anabolism" EXACT [] -synonym: "interleukin-1 biosynthesis" EXACT [] -synonym: "interleukin-1 formation" EXACT [] -synonym: "interleukin-1 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032612 ! interleukin-1 production - -[Term] -id: GO:0042223 -name: interleukin-3 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] -synonym: "IL-3 biosynthesis" EXACT [] -synonym: "IL-3 biosynthetic process" EXACT [] -synonym: "interleukin-3 anabolism" EXACT [] -synonym: "interleukin-3 biosynthesis" EXACT [] -synonym: "interleukin-3 formation" EXACT [] -synonym: "interleukin-3 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032632 ! interleukin-3 production - -[Term] -id: GO:0042225 -name: interleukin-5 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] -synonym: "IL-5 biosynthesis" EXACT [] -synonym: "IL-5 biosynthetic process" EXACT [] -synonym: "interleukin-5 anabolism" EXACT [] -synonym: "interleukin-5 biosynthesis" EXACT [] -synonym: "interleukin-5 formation" EXACT [] -synonym: "interleukin-5 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032634 ! interleukin-5 production - -[Term] -id: GO:0042226 -name: interleukin-6 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] -synonym: "IL-6 biosynthesis" EXACT [] -synonym: "IL-6 biosynthetic process" EXACT [] -synonym: "interleukin-6 anabolism" EXACT [] -synonym: "interleukin-6 biosynthesis" EXACT [] -synonym: "interleukin-6 formation" EXACT [] -synonym: "interleukin-6 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032635 ! interleukin-6 production - -[Term] -id: GO:0042227 -name: interleukin-7 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] -synonym: "IL-7 biosynthesis" EXACT [] -synonym: "IL-7 biosynthetic process" EXACT [] -synonym: "interleukin-7 anabolism" EXACT [] -synonym: "interleukin-7 biosynthesis" EXACT [] -synonym: "interleukin-7 formation" EXACT [] -synonym: "interleukin-7 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032636 ! interleukin-7 production - -[Term] -id: GO:0042228 -name: interleukin-8 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] -synonym: "IL-8 biosynthesis" EXACT [] -synonym: "IL-8 biosynthetic process" EXACT [] -synonym: "interleukin-8 anabolism" EXACT [] -synonym: "interleukin-8 biosynthesis" EXACT [] -synonym: "interleukin-8 formation" EXACT [] -synonym: "interleukin-8 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032637 ! interleukin-8 production - -[Term] -id: GO:0042229 -name: interleukin-9 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] -synonym: "IL-9 biosynthesis" EXACT [] -synonym: "IL-9 biosynthetic process" EXACT [] -synonym: "interleukin-9 anabolism" EXACT [] -synonym: "interleukin-9 biosynthesis" EXACT [] -synonym: "interleukin-9 formation" EXACT [] -synonym: "interleukin-9 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032638 ! interleukin-9 production - -[Term] -id: GO:0042230 -name: interleukin-11 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] -synonym: "IL-11 biosynthesis" EXACT [] -synonym: "IL-11 biosynthetic process" EXACT [] -synonym: "interleukin-11 anabolism" EXACT [] -synonym: "interleukin-11 biosynthesis" EXACT [] -synonym: "interleukin-11 formation" EXACT [] -synonym: "interleukin-11 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032614 ! interleukin-11 production - -[Term] -id: GO:0042231 -name: interleukin-13 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] -synonym: "IL-13 biosynthesis" EXACT [] -synonym: "IL-13 biosynthetic process" EXACT [] -synonym: "interleukin-13 anabolism" EXACT [] -synonym: "interleukin-13 biosynthesis" EXACT [] -synonym: "interleukin-13 formation" EXACT [] -synonym: "interleukin-13 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032616 ! interleukin-13 production - -[Term] -id: GO:0042232 -name: interleukin-14 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] -synonym: "IL-14 biosynthesis" EXACT [] -synonym: "IL-14 biosynthetic process" EXACT [] -synonym: "interleukin-14 anabolism" EXACT [] -synonym: "interleukin-14 biosynthesis" EXACT [] -synonym: "interleukin-14 formation" EXACT [] -synonym: "interleukin-14 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -relationship: part_of GO:0032617 ! interleukin-14 production - -[Term] -id: GO:0042233 -name: interleukin-15 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] -synonym: "IL-15 biosynthesis" EXACT [] -synonym: "IL-15 biosynthetic process" EXACT [] -synonym: "interleukin-15 anabolism" EXACT [] -synonym: "interleukin-15 biosynthesis" EXACT [] -synonym: "interleukin-15 formation" EXACT [] -synonym: "interleukin-15 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032618 ! interleukin-15 production - -[Term] -id: GO:0042234 -name: interleukin-16 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] -synonym: "IL-16 biosynthesis" EXACT [] -synonym: "IL-16 biosynthetic process" EXACT [] -synonym: "interleukin-16 anabolism" EXACT [] -synonym: "interleukin-16 biosynthesis" EXACT [] -synonym: "interleukin-16 formation" EXACT [] -synonym: "interleukin-16 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032619 ! interleukin-16 production - -[Term] -id: GO:0042235 -name: interleukin-17 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators] -synonym: "IL-17 biosynthesis" EXACT [] -synonym: "IL-17 biosynthetic process" EXACT [] -synonym: "interleukin-17 anabolism" EXACT [] -synonym: "interleukin-17 biosynthesis" EXACT [] -synonym: "interleukin-17 formation" EXACT [] -synonym: "interleukin-17 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032620 ! interleukin-17 production - -[Term] -id: GO:0042236 -name: interleukin-19 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] -synonym: "IL-19 biosynthesis" EXACT [] -synonym: "IL-19 biosynthetic process" EXACT [] -synonym: "interleukin-19 anabolism" EXACT [] -synonym: "interleukin-19 biosynthesis" EXACT [] -synonym: "interleukin-19 formation" EXACT [] -synonym: "interleukin-19 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032622 ! interleukin-19 production - -[Term] -id: GO:0042237 -name: interleukin-20 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] -synonym: "IL-20 biosynthesis" EXACT [] -synonym: "IL-20 biosynthetic process" EXACT [] -synonym: "interleukin-20 anabolism" EXACT [] -synonym: "interleukin-20 biosynthesis" EXACT [] -synonym: "interleukin-20 formation" EXACT [] -synonym: "interleukin-20 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032624 ! interleukin-20 production - -[Term] -id: GO:0042238 -name: interleukin-21 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] -synonym: "IL-21 biosynthesis" EXACT [] -synonym: "IL-21 biosynthetic process" EXACT [] -synonym: "interleukin-21 anabolism" EXACT [] -synonym: "interleukin-21 biosynthesis" EXACT [] -synonym: "interleukin-21 formation" EXACT [] -synonym: "interleukin-21 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032625 ! interleukin-21 production - -[Term] -id: GO:0042239 -name: interleukin-22 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] -synonym: "IL-22 biosynthesis" EXACT [] -synonym: "IL-22 biosynthetic process" EXACT [] -synonym: "interleukin-22 anabolism" EXACT [] -synonym: "interleukin-22 biosynthesis" EXACT [] -synonym: "interleukin-22 formation" EXACT [] -synonym: "interleukin-22 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032626 ! interleukin-22 production - -[Term] -id: GO:0042240 -name: interleukin-23 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] -synonym: "IL-23 biosynthesis" EXACT [] -synonym: "IL-23 biosynthetic process" EXACT [] -synonym: "interleukin-23 anabolism" EXACT [] -synonym: "interleukin-23 biosynthesis" EXACT [] -synonym: "interleukin-23 formation" EXACT [] -synonym: "interleukin-23 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -relationship: part_of GO:0032627 ! interleukin-23 production - -[Term] -id: GO:0042241 -name: interleukin-18 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] -synonym: "IL-18 biosynthesis" EXACT [] -synonym: "IL-18 biosynthetic process" EXACT [] -synonym: "interleukin-18 anabolism" EXACT [] -synonym: "interleukin-18 biosynthesis" EXACT [] -synonym: "interleukin-18 formation" EXACT [] -synonym: "interleukin-18 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032621 ! interleukin-18 production - [Term] id: GO:0042242 name: cobyrinic acid a,c-diamide synthase activity @@ -237899,7 +238025,6 @@ def: "The regrowth of lost or destroyed tissues." [GOC:curators] is_a: GO:0009888 ! tissue development is_a: GO:0031099 ! regeneration is_a: GO:0048589 ! developmental growth -relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0042247 @@ -238211,6 +238336,7 @@ synonym: "multiheme nitrite reductase activity" EXACT [] synonym: "nitrite reductase (cytochrome; ammonia-forming)" EXACT [EC:1.7.2.2] xref: EC:1.7.2.2 xref: MetaCyc:1.7.2.2-RXN +xref: RHEA:13089 xref: Wikipedia:Cytochrome_c_nitrite_reductase is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor is_a: GO:0098809 ! nitrite reductase activity @@ -238234,6 +238360,7 @@ def: "Catalysis of the addition of the first glucose residue to the lipid-linked synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: EC:2.4.1.267 xref: MetaCyc:RXN-5470 +xref: RHEA:30635 is_a: GO:0046527 ! glucosyltransferase activity relationship: part_of GO:0006490 ! oligosaccharide-lipid intermediate biosynthetic process @@ -238264,6 +238391,7 @@ def: "Catalysis of the addition of the second glucose residue to the lipid-linke synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] xref: EC:2.4.1.265 xref: MetaCyc:RXN-5471 +xref: RHEA:31307 is_a: GO:0046527 ! glucosyltransferase activity [Term] @@ -238397,6 +238525,7 @@ def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction i synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99 xref: MetaCyc:RXN-111 +xref: RHEA:31383 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] @@ -238591,8 +238720,6 @@ synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "prolinase activity" NARROW [EC:3.4.13.18] synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18] synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18] -xref: EC:3.4.13.18 -xref: MetaCyc:3.4.13.18-RXN is_obsolete: true replaced_by: GO:0016805 @@ -239053,7 +239180,6 @@ synonym: "thiamine pyrophosphate metabolism" EXACT [] synonym: "TPP metabolic process" EXACT [] synonym: "TPP metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process @@ -239075,7 +239201,6 @@ synonym: "thiamine pyrophosphate catabolic process" EXACT [] synonym: "thiamine pyrophosphate catabolism" EXACT [] synonym: "TPP catabolic process" EXACT [] synonym: "TPP catabolism" EXACT [] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042357 ! thiamine diphosphate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process @@ -239189,8 +239314,6 @@ synonym: "vitamin B12 catabolism" EXACT [] is_a: GO:0009235 ! cobalamin metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process -is_a: GO:0042737 ! drug catabolic process -is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0042367 @@ -239205,9 +239328,7 @@ synonym: "vitamin B7 catabolism" EXACT [] synonym: "vitamin H catabolic process" EXACT [] synonym: "vitamin H catabolism" EXACT [] is_a: GO:0006768 ! biotin metabolic process -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process @@ -239295,7 +239416,6 @@ synonym: "phytylmenaquinone biosynthetic process" EXACT [] synonym: "vitamin K1 biosynthesis" EXACT [] synonym: "vitamin K1 biosynthetic process" EXACT [] xref: MetaCyc:PWY-5027 -is_a: GO:0009110 ! vitamin biosynthetic process is_a: GO:0042374 ! phylloquinone metabolic process is_a: GO:1901663 ! quinone biosynthetic process @@ -239323,7 +239443,6 @@ synonym: "phytylmenaquinone metabolic process" EXACT [] synonym: "phytylmenaquinone metabolism" EXACT [] synonym: "vitamin K1 metabolic process" EXACT [] synonym: "vitamin K1 metabolism" EXACT [] -is_a: GO:0006766 ! vitamin metabolic process is_a: GO:1901661 ! quinone metabolic process [Term] @@ -239342,7 +239461,6 @@ synonym: "phytylmenaquinone catabolic process" EXACT [] synonym: "phytylmenaquinone catabolism" EXACT [] synonym: "vitamin K1 catabolic process" EXACT [] synonym: "vitamin K1 catabolism" EXACT [] -is_a: GO:0009111 ! vitamin catabolic process is_a: GO:0042374 ! phylloquinone metabolic process is_a: GO:1901662 ! quinone catabolic process @@ -239462,7 +239580,7 @@ is_a: GO:0065008 ! regulation of biological quality id: GO:0042392 name: sphingosine-1-phosphate phosphatase activity namespace: molecular_function -def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:11331102] +def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:8663293] synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT [] synonym: "SPP phosphatase activity" EXACT [] synonym: "SPPase activity" EXACT [] @@ -239470,6 +239588,7 @@ xref: MetaCyc:RXN3DJ-25 xref: Reactome:R-HSA-428690 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]" xref: Reactome:R-HSA-428696 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]" xref: Reactome:R-HSA-428701 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]" +xref: RHEA:27518 is_a: GO:0042577 ! lipid phosphatase activity [Term] @@ -239755,7 +239874,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] synonym: "dopamine metabolism" EXACT [] is_a: GO:0006584 ! catecholamine metabolic process -is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0042418 @@ -239794,7 +239912,6 @@ synonym: "dopamine catabolism" EXACT [] synonym: "dopamine degradation" EXACT [] is_a: GO:0042417 ! dopamine metabolic process is_a: GO:0042424 ! catecholamine catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0042421 @@ -239865,7 +239982,6 @@ synonym: "choline formation" EXACT [] synonym: "choline synthesis" EXACT [] xref: MetaCyc:PWY-4762 is_a: GO:0019695 ! choline metabolic process -is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] @@ -239877,7 +239993,6 @@ synonym: "choline breakdown" EXACT [] synonym: "choline catabolism" EXACT [] synonym: "choline degradation" EXACT [] is_a: GO:0019695 ! choline metabolic process -is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] @@ -239890,7 +240005,6 @@ synonym: "serotonin biosynthesis" EXACT [] synonym: "serotonin formation" EXACT [] synonym: "serotonin synthesis" EXACT [] xref: Wikipedia:Serotonin -is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process @@ -239903,7 +240017,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process -is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process @@ -239917,7 +240030,6 @@ synonym: "serotonin breakdown" EXACT [] synonym: "serotonin catabolism" EXACT [] synonym: "serotonin degradation" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process -is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042428 ! serotonin metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:1901161 ! primary amino compound catabolic process @@ -240078,7 +240190,6 @@ synonym: "melatonin degradation" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042436 ! indole-containing compound catabolic process is_a: GO:0042447 ! hormone catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0042443 @@ -240143,7 +240254,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone metabolism" EXACT [] is_a: GO:0008207 ! C21-steroid hormone metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] @@ -240224,7 +240334,6 @@ synonym: "ethylene breakdown" EXACT [] synonym: "ethylene catabolism" EXACT [] synonym: "ethylene degradation" EXACT [] is_a: GO:0009692 ! ethylene metabolic process -is_a: GO:0042447 ! hormone catabolic process is_a: GO:0043451 ! alkene catabolic process [Term] @@ -240651,7 +240760,6 @@ def: "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, comment: This term was made obsolete because it represents a gene product. synonym: "signal peptide peptidase activity" EXACT [] synonym: "SPP" EXACT [] -xref: EC:3.4.23 is_obsolete: true replaced_by: GO:0042500 @@ -240997,10 +241105,7 @@ name: response to hydrogen peroxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl] is_a: GO:0000302 ! response to reactive oxygen species -is_a: GO:0009636 ! response to toxic substance is_a: GO:0010035 ! response to inorganic substance -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic [Term] id: GO:0042543 @@ -241150,6 +241255,7 @@ id: GO:0042559 name: pteridine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] +subset: goslim_pombe synonym: "pteridine and derivative biosynthesis" EXACT [] synonym: "pteridine and derivative biosynthetic process" EXACT [] synonym: "pteridine-containing compound anabolism" EXACT [] @@ -241315,8 +241421,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21] comment: This term was made obsolete because it represents a gene product. synonym: "aspartyl aminopeptidase activity" EXACT [] -xref: EC:3.4.11.21 -xref: MetaCyc:3.4.11.21-RXN is_obsolete: true replaced_by: GO:0004177 @@ -241402,6 +241506,7 @@ synonym: "PDF activity" EXACT [EC:3.5.1.88] synonym: "polypeptide deformylase activity" EXACT [EC:3.5.1.88] xref: EC:3.5.1.88 xref: MetaCyc:3.5.1.88-RXN +xref: RHEA:24420 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -241673,7 +241778,6 @@ synonym: "paclitaxel metabolism" EXACT [] synonym: "taxol metabolic process" NARROW [] synonym: "taxol metabolism" NARROW [] is_a: GO:0016101 ! diterpenoid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] @@ -241694,7 +241798,7 @@ is_a: GO:0042616 ! paclitaxel metabolic process id: GO:0042618 name: poly-hydroxybutyrate metabolic process namespace: biological_process -def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl\,PMID\:18640095] +def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, PMID:18640095] synonym: "PHB metabolic process" EXACT [] synonym: "PHB metabolism" EXACT [] synonym: "poly-hydroxybutyrate metabolism" EXACT [] @@ -241780,11 +241884,6 @@ synonym: "hydrolase activity, acting on acid anhydrides, catalyzing transmembran synonym: "P-P-bond-hydrolysis-driven transmembrane transporter activity" BROAD [] synonym: "P-P-bond-hydrolysis-driven transporter" BROAD [] xref: EC:7.2.2 -xref: Reactome:R-HSA-266070 "LTC4 is exported from the cytosol by ABCC1" -xref: Reactome:R-HSA-5223313 "ABCD4 may transport Cbl from lysosomal lumen to cytosol" -xref: Reactome:R-HSA-5362459 "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol" -xref: Reactome:R-HSA-5387389 "Hh processing variants are translocated to the cytosol in a VCP-dependent manner" -xref: Reactome:R-HSA-5683325 "Defective ABCD4 does not transport Cbl from lysosomal lumen to cytosol" is_a: GO:0015399 ! primary active transmembrane transporter activity relationship: has_part GO:0016887 ! ATPase activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14642 xsd:anyURI @@ -241960,13 +242059,12 @@ relationship: part_of GO:0042641 ! actomyosin [Term] id: GO:0042643 -name: actomyosin, actin portion +name: obsolete actomyosin, actin portion namespace: cellular_component -def: "The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] -is_a: GO:0005884 ! actin filament -intersection_of: GO:0005884 ! actin filament -intersection_of: part_of GO:0042641 ! actomyosin -relationship: part_of GO:0042641 ! actomyosin +def: "OBSOLETE. The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] +comment: This term was obsoleted because it corresponds to a gene product, actin. +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19570 xsd:anyURI +is_obsolete: true [Term] id: GO:0042644 @@ -242524,7 +242622,6 @@ id: GO:0042701 name: progesterone secretion namespace: biological_process def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172] -is_a: GO:0015893 ! drug transport is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022602 ! ovulation cycle process is_a: GO:0035929 ! steroid hormone secretion @@ -242733,7 +242830,6 @@ synonym: "vitamin B1 and derivative metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] @@ -242776,7 +242872,6 @@ synonym: "vitamin B1 and derivative catabolism" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042723 ! thiamine-containing compound metabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process @@ -242987,8 +243082,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, PMID:21734470] synonym: "H2O2 metabolic process" EXACT [GOC:mah] synonym: "hydrogen peroxide metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process -is_a: GO:0051186 ! cofactor metabolic process is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] @@ -243005,10 +243098,8 @@ synonym: "hydrogen peroxide catabolism" EXACT [] synonym: "hydrogen peroxide degradation" EXACT [] synonym: "hydrogen peroxide removal" RELATED [] synonym: "hydrogen peroxide scavenging" RELATED [GOC:vw] -is_a: GO:0017001 ! antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0042743 ! hydrogen peroxide metabolic process -is_a: GO:0051187 ! cofactor catabolic process +is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0042745 @@ -243219,8 +243310,8 @@ namespace: cellular_component def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054] comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity. synonym: "GPIT complex" EXACT [] +is_a: GO:0008303 ! caspase complex is_a: GO:0098796 ! membrane protein complex -is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane @@ -243756,7 +243847,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "vitamin B6 metabolism" EXACT [] is_a: GO:0006767 ! water-soluble vitamin metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] @@ -243768,7 +243858,6 @@ synonym: "pyridoxal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0042816 ! vitamin B6 metabolic process -is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] @@ -243804,7 +243893,6 @@ synonym: "vitamin B6 breakdown" EXACT [] synonym: "vitamin B6 catabolism" EXACT [] synonym: "vitamin B6 degradation" EXACT [] is_a: GO:0042365 ! water-soluble vitamin catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process @@ -243821,20 +243909,18 @@ is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042817 ! pyridoxal metabolic process is_a: GO:0042819 ! vitamin B6 biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0042822 name: pyridoxal phosphate metabolic process namespace: biological_process -def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] +def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl] synonym: "active vitamin B6 metabolic process" EXACT [] synonym: "active vitamin B6 metabolism" EXACT [] synonym: "pyridoxal phosphate metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0042816 ! vitamin B6 metabolic process @@ -243844,7 +243930,7 @@ is_a: GO:1901615 ! organic hydroxy compound metabolic process id: GO:0042823 name: pyridoxal phosphate biosynthetic process namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] +def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl] synonym: "active vitamin B6 biosynthesis" EXACT [] synonym: "active vitamin B6 biosynthetic process" EXACT [] synonym: "pyridoxal phosphate anabolism" EXACT [] @@ -243852,7 +243938,6 @@ synonym: "pyridoxal phosphate biosynthesis" EXACT [] synonym: "pyridoxal phosphate formation" EXACT [] synonym: "pyridoxal phosphate synthesis" EXACT [] xref: MetaCyc:PWY0-845 -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042819 ! vitamin B6 biosynthetic process is_a: GO:0042822 ! pyridoxal phosphate metabolic process @@ -243893,7 +243978,7 @@ is_a: GO:0019899 ! enzyme binding id: GO:0042827 name: platelet dense granule namespace: cellular_component -def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682, PMID:11487378] +def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, PMID:10403682, PMID:11487378] synonym: "bull's eye body" EXACT [] synonym: "platelet dense body" EXACT [] is_a: GO:0030141 ! secretory granule @@ -243934,7 +244019,6 @@ def: "The chemical reactions and pathways involving D-glucarate, the D-enantiome synonym: "D-glucarate metabolism" EXACT [] synonym: "saccharate metabolic process" EXACT [] synonym: "saccharate metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0019392 ! glucarate metabolic process [Term] @@ -243962,7 +244046,6 @@ synonym: "D-glucarate degradation" EXACT [] synonym: "saccharate catabolic process" EXACT [] synonym: "saccharate catabolism" EXACT [] is_a: GO:0019394 ! glucarate catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0042836 ! D-glucarate metabolic process [Term] @@ -244372,7 +244455,6 @@ name: D-glucarate transmembrane transport namespace: biological_process def: "The process in which D-glucarate, the D-enantiomer of glucarate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "D-glucarate transport" RELATED [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0042869 ! aldarate transmembrane transport [Term] @@ -244535,9 +244617,9 @@ name: chloramphenicol transmembrane transport namespace: biological_process def: "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, across a lipid bilayer, from one side of a membrane to the other." [PMID:29150447] synonym: "chloramphenicol transport" BROAD [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015791 ! polyol transport is_a: GO:0042886 ! amide transport +is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0042893 @@ -244656,7 +244738,6 @@ name: 9-cis-retinoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029] synonym: "9-cis-retinoic acid metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0042573 ! retinoic acid metabolic process [Term] @@ -244782,7 +244863,6 @@ name: benzoate transport namespace: biological_process def: "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0721662544] is_a: GO:0015718 ! monocarboxylic acid transport -is_a: GO:0015893 ! drug transport is_a: GO:0042908 ! xenobiotic transport [Term] @@ -244880,7 +244960,7 @@ synonym: "enterochelin transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015891 ! siderophore transport -is_a: GO:0051181 ! cofactor transport +is_a: GO:0042969 ! lactone transport [Term] id: GO:0042931 @@ -244891,7 +244971,7 @@ synonym: "enterobactin transporter activity" RELATED [] synonym: "enterochelin transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015343 ! siderophore transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity +is_a: GO:0042971 ! lactone transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0042930 ! enterobactin transport @@ -244900,11 +244980,11 @@ id: GO:0042932 name: chrysobactin transport namespace: biological_process def: "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:8837459] +is_a: GO:0015695 ! organic cation transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015891 ! siderophore transport is_a: GO:0042938 ! dipeptide transport -is_a: GO:0051181 ! cofactor transport [Term] id: GO:0042933 @@ -244913,9 +244993,9 @@ namespace: molecular_function def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other." [GOC:jl, PMID:8837459] synonym: "chrysobactin transporter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0071916 ! dipeptide transmembrane transporter activity relationship: part_of GO:0042932 ! chrysobactin transport @@ -244928,7 +245008,6 @@ synonym: "achromobactin transporter activity" RELATED [] is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity -is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity relationship: part_of GO:0042935 ! achromobactin transport @@ -244941,7 +245020,6 @@ is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0015891 ! siderophore transport is_a: GO:0042886 ! amide transport is_a: GO:0046942 ! carboxylic acid transport -is_a: GO:0051181 ! cofactor transport [Term] id: GO:0042937 @@ -244986,7 +245064,6 @@ id: GO:0042942 name: D-serine transport namespace: biological_process def: "The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] -is_a: GO:0015893 ! drug transport is_a: GO:0032329 ! serine transport is_a: GO:0042940 ! D-amino acid transport @@ -245042,7 +245119,6 @@ namespace: biological_process def: "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0015759 ! beta-glucoside transport is_a: GO:0015850 ! organic hydroxy compound transport -is_a: GO:0015893 ! drug transport [Term] id: GO:0042949 @@ -245090,7 +245166,6 @@ name: obsolete lipoprotein transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732] comment: The reason for obsoletion is this term has been incorrectly used. -xref: Reactome:R-HSA-350168 "LRP2 transports CUBN:GC:25(OH)D from extracellular region to cytosol" property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17004 xsd:anyURI is_obsolete: true @@ -245098,21 +245173,21 @@ is_obsolete: true id: GO:0042955 name: dextrin transport namespace: biological_process -def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/] +def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0042956 name: maltodextrin transport namespace: biological_process -def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/] +def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0042957 name: dextrin transmembrane transporter activity namespace: molecular_function -def: "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other." [GOC:jl, GOC:vk, http://www.mercksource.com/] +def: "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other." [GOC:jl, GOC:vk] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity relationship: part_of GO:0042955 ! dextrin transport @@ -245120,7 +245195,7 @@ relationship: part_of GO:0042955 ! dextrin transport id: GO:0042958 name: maltodextrin transmembrane transporter activity namespace: molecular_function -def: "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other." [GOC:jl, http://www.mercksource.com/, PMID:15034926] +def: "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other." [GOC:jl, PMID:15034926] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity relationship: part_of GO:0042956 ! maltodextrin transport @@ -245755,6 +245830,7 @@ alt_id: GO:0001747 alt_id: GO:0031075 def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001654 ! eye development +property_value: RO:0002161 NCBITaxon:6656 [Term] id: GO:0043011 @@ -246835,7 +246911,7 @@ name: neurotrophin binding namespace: molecular_function alt_id: GO:0048404 alt_id: GO:0048405 -def: "Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl, http://www.mercksource.com/, PR:000021998] +def: "Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl] comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858]. synonym: "neurotrophic factor binding" EXACT [GOC:aruk, GOC:bc] synonym: "neurotrophin 3 binding" NARROW [] @@ -246995,7 +247071,6 @@ synonym: "oxidized nicotinamide adenine dinucleotide transport" EXACT [] synonym: "reduced NAD transport" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport -is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0043133 @@ -247052,6 +247127,14 @@ def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwindi synonym: "3' to 5' DNA helicase activity" EXACT [] synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT [] synonym: "ATP-dependent 3'-5' DNA helicase activity" EXACT [] +xref: Reactome:R-HSA-167097 "HIV Promoter Opening: First Transition" +xref: Reactome:R-HSA-174438 "Formation of the Flap Intermediate on the C-strand" +xref: Reactome:R-HSA-75949 "RNA Polymerase II Promoter Opening: First Transition" +xref: Reactome:R-HSA-9613490 "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition" +xref: Reactome:R-HSA-9613494 "Unwinding of DNA for the Nascent Transcript: Second Transition" +xref: Reactome:R-HSA-9613497 "Unwinding DNA for the nascent transcript" +xref: Reactome:R-HSA-9613498 "Unwinding of DNA for the nascent HIV-1 transcript" +xref: Reactome:R-HSA-9684118 "ERCC3-facilitated RNA Pol II backtracking in TC-NER" is_a: GO:0003678 ! DNA helicase activity [Term] @@ -247065,6 +247148,7 @@ synonym: "5' to 3' DNA helicase activity" EXACT [] synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT [] synonym: "ATP-dependent 5'-3' DNA helicase activity" EXACT [] synonym: "DNA helicase IV activity" NARROW [] +xref: Reactome:R-HSA-6782131 "ERCC2-facilitated RNA Pol II backtracking in TC-NER" is_a: GO:0003678 ! DNA helicase activity [Term] @@ -247489,15 +247573,6 @@ synonym: "polar granule" EXACT [] is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule relationship: part_of GO:0060293 ! germ plasm -[Term] -id: GO:0043187 -name: cell septum surface -namespace: cellular_component -def: "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators] -synonym: "septum surface" BROAD [] -is_a: GO:0110165 ! cellular anatomical entity -relationship: part_of GO:0030428 ! cell septum - [Term] id: GO:0043188 name: cell septum edging @@ -247712,6 +247787,7 @@ name: ATPase-coupled bacteriocin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate." [GOC:mlg] synonym: "bacteriocin ABC transporter" NARROW [] +is_a: GO:0008559 ! ATPase-coupled xenobiotic transmembrane transporter activity is_a: GO:0015440 ! ATPase-coupled peptide transmembrane transporter activity is_a: GO:0022885 ! bacteriocin transmembrane transporter activity @@ -247719,7 +247795,7 @@ is_a: GO:0022885 ! bacteriocin transmembrane transporter activity id: GO:0043215 name: daunorubicin transport namespace: biological_process -def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg, http://www.mercksource.com/] +def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg] is_a: GO:0015695 ! organic cation transport is_a: GO:0015893 ! drug transport is_a: GO:0071705 ! nitrogen compound transport @@ -248165,6 +248241,7 @@ synonym: "ADPase activity" EXACT [EC:3.6.1.5] synonym: "ATP diphosphohydrolase activity" EXACT [EC:3.6.1.5] synonym: "ATP-diphosphatase activity" EXACT [EC:3.6.1.5] xref: MetaCyc:APYRASE-RXN +xref: RHEA:20988 is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] @@ -248358,7 +248435,6 @@ synonym: "pteroylpolygammaglutamyl hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21] synonym: "pteroylpolyglutamic acid hydrolase activity" EXACT [EC:3.4.17.21] synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21] -xref: EC:3.4.17.21 is_obsolete: true replaced_by: GO:0004181 @@ -248388,9 +248464,7 @@ id: GO:0043278 name: response to morphine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:ef, GOC:jl] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014072 ! response to isoquinoline alkaloid -is_a: GO:0072347 ! response to anesthetic [Term] id: GO:0043279 @@ -248544,7 +248618,6 @@ name: glutathione binding namespace: molecular_function def: "Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732] is_a: GO:0043168 ! anion binding -is_a: GO:0048037 ! cofactor binding is_a: GO:0072341 ! modified amino acid binding is_a: GO:1900750 ! oligopeptide binding is_a: GO:1901681 ! sulfur compound binding @@ -248641,10 +248714,9 @@ synonym: "mast cell granule exocytosis" EXACT [] is_a: GO:0002279 ! mast cell activation involved in immune response is_a: GO:0032418 ! lysosome localization is_a: GO:0043299 ! leukocyte degranulation -is_a: GO:0046907 ! intracellular transport is_a: GO:0051656 ! establishment of organelle localization -relationship: occurs_in GO:0042629 ! mast cell granule relationship: part_of GO:0002448 ! mast cell mediated immunity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/15943 xsd:anyURI [Term] id: GO:0043304 @@ -248653,7 +248725,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149] synonym: "regulation of mast cell granule exocytosis" EXACT [] is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity -is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0033006 ! regulation of mast cell activation involved in immune response is_a: GO:0043300 ! regulation of leukocyte degranulation intersection_of: GO:0008150 ! biological_process @@ -248671,7 +248742,6 @@ synonym: "downregulation of mast cell degranulation" EXACT [] synonym: "inhibition of mast cell degranulation" NARROW [] synonym: "negative regulation of mast cell granule exocytosis" EXACT [] is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity -is_a: GO:0032387 ! negative regulation of intracellular transport is_a: GO:0033007 ! negative regulation of mast cell activation involved in immune response is_a: GO:0043301 ! negative regulation of leukocyte degranulation is_a: GO:0043304 ! regulation of mast cell degranulation @@ -248691,7 +248761,6 @@ synonym: "up regulation of mast cell degranulation" EXACT [] synonym: "up-regulation of mast cell degranulation" EXACT [] synonym: "upregulation of mast cell degranulation" EXACT [] is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity -is_a: GO:0032388 ! positive regulation of intracellular transport is_a: GO:0033008 ! positive regulation of mast cell activation involved in immune response is_a: GO:0043302 ! positive regulation of leukocyte degranulation is_a: GO:0043304 ! regulation of mast cell degranulation @@ -249141,6 +249210,7 @@ synonym: "cardiolipin synthase" BROAD [] synonym: "cardiolipin synthetase" BROAD [] xref: MetaCyc:RXN-8141 xref: Reactome:R-HSA-1483063 "PG and CDP-DAG are converted to CL by CRLS1" +xref: RHEA:32931 is_a: GO:0030572 ! phosphatidyltransferase activity [Term] @@ -249218,6 +249288,7 @@ synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizin synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4] xref: EC:1.97.1.4 xref: MetaCyc:TDCEACT-RXN +xref: RHEA:19225 is_a: GO:0043364 ! glycyl-radical enzyme activating activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14190 xsd:anyURI @@ -249635,7 +249706,6 @@ def: "The regulated release of corticotropin-releasing hormone (CRH), a polypept synonym: "corticotropin-releasing factor secretion" EXACT [] synonym: "CRF secretion" EXACT [] synonym: "CRH secretion" EXACT [] -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0030072 ! peptide hormone secretion [Term] @@ -249646,7 +249716,6 @@ def: "Any process that modulates the frequency, rate or extent of corticotropin- synonym: "regulation of corticotropin-releasing factor secretion" EXACT [] synonym: "regulation of CRF secretion" EXACT [] synonym: "regulation of CRH secretion" EXACT [] -is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:0090276 ! regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043396 ! corticotropin-releasing hormone secretion @@ -249675,7 +249744,6 @@ namespace: biological_process def: "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [PMID:11027914] synonym: "hydrocortisone secretion" EXACT [CHEBI:17650] is_a: GO:0015850 ! organic hydroxy compound transport -is_a: GO:0015893 ! drug transport is_a: GO:0035933 ! glucocorticoid secretion [Term] @@ -249887,7 +249955,6 @@ synonym: "up-regulation of skeletal muscle regeneration" EXACT [] synonym: "upregulation of skeletal muscle regeneration" EXACT [] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0048639 ! positive regulation of developmental growth -is_a: GO:0090303 ! positive regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration relationship: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration @@ -249899,7 +249966,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048638 ! regulation of developmental growth -is_a: GO:0061041 ! regulation of wound healing is_a: GO:2000026 ! regulation of multicellular organismal development intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043403 ! skeletal muscle tissue regeneration @@ -249916,7 +249982,6 @@ synonym: "downregulation of skeletal muscle regeneration" EXACT [] synonym: "inhibition of skeletal muscle regeneration" NARROW [] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0048640 ! negative regulation of developmental growth -is_a: GO:0061045 ! negative regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration relationship: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration @@ -249961,7 +250026,6 @@ synonym: "anthranilic acid metabolism" NARROW [] synonym: "ortho-aminobenzoic acid metabolic process" NARROW [] synonym: "ortho-aminobenzoic acid metabolism" NARROW [] xref: UM-BBD_pathwayID:abz2 -is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -249986,7 +250050,6 @@ synonym: "ortho-aminobenzoic acid catabolism" NARROW [] xref: MetaCyc:2AMINOBENZDEG-PWY is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0042178 ! xenobiotic catabolic process -is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0043420 ! anthranilate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process @@ -250058,6 +250121,7 @@ def: "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-ad comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: MetaCyc:RXN-9227 +xref: RHEA:44756 is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] @@ -250077,6 +250141,7 @@ def: "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-ade comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] xref: Reactome:R-HSA-2162188 "MDMQ10H2 is methylated to DMQ10H2 by COQ5" +xref: RHEA:44764 is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [Term] @@ -251016,7 +251081,7 @@ relationship: part_of GO:0005615 ! extracellular space id: GO:0043515 name: kinetochore binding namespace: molecular_function -def: "Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl, http://www.mercksource.com/] +def: "Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl] is_a: GO:0005488 ! binding [Term] @@ -251361,7 +251426,6 @@ def: "The chemical reactions and pathways involving the molybdopterin cofactor ( synonym: "Moco metabolic process" EXACT [] synonym: "Moco metabolism" EXACT [] synonym: "molybdopterin cofactor metabolism" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0046483 ! heterocycle metabolic process @@ -251375,7 +251439,6 @@ name: molybdopterin cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] synonym: "Moco binding" EXACT [] -is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding @@ -251806,7 +251869,7 @@ is_a: GO:0007423 ! sensory organ development id: GO:0043584 name: nose development namespace: biological_process -def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/] +def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl] synonym: "nasus development" EXACT [] is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0060541 ! respiratory system development @@ -251815,7 +251878,7 @@ relationship: part_of GO:0060541 ! respiratory system development id: GO:0043585 name: nose morphogenesis namespace: biological_process -def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/] +def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl] synonym: "nasus morphogenesis" EXACT [] is_a: GO:0090596 ! sensory organ morphogenesis relationship: part_of GO:0043584 ! nose development @@ -252038,7 +252101,7 @@ is_a: GO:1901566 ! organonitrogen compound biosynthetic process id: GO:0043608 name: formamide catabolic process namespace: biological_process -def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/] +def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl] is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0043606 ! formamide metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process @@ -252215,7 +252278,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732] synonym: "response to estrogen stimulus" EXACT [GOC:dos] synonym: "response to oestrogen stimulus" EXACT [] -is_a: GO:0050896 ! response to stimulus +is_a: GO:0009725 ! response to hormone [Term] id: GO:0043628 @@ -252305,8 +252368,6 @@ synonym: "bisphenol-A catabolic process" EXACT [] synonym: "bisphenol-A catabolism" EXACT [] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process -is_a: GO:0042447 ! hormone catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0043637 @@ -252334,10 +252395,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of benzoate synonym: "benzoate breakdown" EXACT [] synonym: "benzoate catabolism" EXACT [] synonym: "benzoate degradation" EXACT [] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018874 ! benzoate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -253077,6 +253136,7 @@ synonym: "2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity" EXA synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT [] xref: KEGG_REACTION:R07394 xref: MetaCyc:R83-RXN +xref: RHEA:14481 is_a: GO:0016791 ! phosphatase activity [Term] @@ -253086,6 +253146,7 @@ namespace: molecular_function def: "Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA." [MetaCyc:RXN-1083] synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT [] xref: MetaCyc:RXN-1083 +xref: RHEA:42448 is_a: GO:0016836 ! hydro-lyase activity [Term] @@ -253118,6 +253179,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [MetaCyc:R125-RXN, PMID:13064] synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT [] xref: MetaCyc:R125-RXN +xref: RHEA:31555 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -253177,8 +253239,8 @@ namespace: molecular_function alt_id: GO:0019173 def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl] synonym: "pyrimidine phosphatase activity" EXACT [GOC:mah] -xref: EC:3.1.3 xref: MetaCyc:RIBOPHOSPHAT-RXN +xref: RHEA:25197 is_a: GO:0016791 ! phosphatase activity [Term] @@ -253218,6 +253280,7 @@ namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591] xref: EC:1.14.13.114 xref: MetaCyc:RXN-7573 +xref: RHEA:27333 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -253339,6 +253402,7 @@ name: LPPG:FO 2-phospho-L-lactate transferase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [PMID:11888293] xref: EC:2.7.8.28 +xref: RHEA:27510 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] @@ -253450,6 +253514,7 @@ synonym: "dihydrolipoyl transacylase activity" EXACT [EC:2.3.1.168] synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT [] xref: EC:2.3.1.168 xref: MetaCyc:2.3.1.168-RXN +xref: RHEA:18865 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -253492,6 +253557,7 @@ synonym: "AdoCbi-P synthase activity" EXACT [EC:6.3.1.10] synonym: "CbiB" RELATED [] xref: EC:6.3.1.10 xref: MetaCyc:RXN-6261 +xref: RHEA:21896 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] @@ -253577,6 +253643,7 @@ synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT [] synonym: "SepCysS" RELATED [] xref: EC:2.5.1.73 xref: MetaCyc:RXN-10719 +xref: RHEA:25686 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA relationship: part_of GO:0071952 ! conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA @@ -253677,6 +253744,7 @@ synonym: "precorrin-6 methyltransferase activity" EXACT [] synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] synonym: "precorrin-6Y methylase" BROAD [] xref: MetaCyc:RXN-8766 +xref: RHEA:36067 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -253689,6 +253757,7 @@ synonym: "precorrin-6 methyltransferase" BROAD [] synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] synonym: "precorrin-6Y methylase" BROAD [] xref: MetaCyc:RXN-8767 +xref: RHEA:34591 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -253711,6 +253780,7 @@ namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde." [MetaCyc:RXN-8763] synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT [] xref: MetaCyc:RXN-8763 +xref: RHEA:26281 is_a: GO:0016829 ! lyase activity [Term] @@ -253720,6 +253790,7 @@ namespace: molecular_function def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [MetaCyc:RXN-8764] synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT [] xref: MetaCyc:RXN-8764 +xref: RHEA:26285 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -253746,6 +253817,7 @@ synonym: "cobalt-precorrin-3 methylase" BROAD [] synonym: "cobalt-precorrin-3 methyltransferase" BROAD [] synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT [] xref: MetaCyc:RXN-8761 +xref: RHEA:26273 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -253803,6 +253875,7 @@ synonym: "MT1" BROAD [] synonym: "mtbB1" RELATED [] xref: EC:2.1.1.249 xref: MetaCyc:RXN-8100 +xref: RHEA:41175 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -253850,6 +253923,7 @@ name: glyceraldehyde dehydrogenase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [EC:1.2.1.89] xref: EC:1.2.1.89 +xref: RHEA:40163 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -253875,6 +253949,7 @@ synonym: "D-glycerate 2-kinase activity" EXACT [] synonym: "glycerate kinase" BROAD [] xref: EC:2.7.1 xref: MetaCyc:GKI-RXN +xref: RHEA:27377 is_a: GO:0016301 ! kinase activity is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor @@ -253959,6 +254034,7 @@ synonym: "indolepyruvate oxidoreductase activity" EXACT [EC:1.2.7.8] synonym: "IOR" RELATED [] xref: EC:1.2.7.8 xref: MetaCyc:1.2.7.8-RXN +xref: RHEA:12645 is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] @@ -253990,6 +254066,7 @@ synonym: "ketoisovalerate oxidoreductase activity" EXACT [EC:1.2.7.7] synonym: "VOR" RELATED [] xref: EC:1.2.7.7 xref: MetaCyc:1.2.7.7-RXN +xref: RHEA:11712 is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] @@ -254023,7 +254100,6 @@ name: phosphatidylinositol-4-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [PMID:10224048] synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT [] -xref: EC:3.1.3 is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity @@ -254033,7 +254109,6 @@ name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [PMID:10806194, PMID:16607019] synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT [] -xref: EC:3.1.3 xref: Reactome:R-HSA-1675836 "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane" xref: Reactome:R-HSA-1676005 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane" xref: Reactome:R-HSA-1676020 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane" @@ -254049,6 +254124,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate." [PMID:18260642] xref: EC:2.7.7.68 xref: MetaCyc:RXN-8077 +xref: RHEA:30519 is_a: GO:0070568 ! guanylyltransferase activity [Term] @@ -254061,6 +254137,7 @@ synonym: "formate-dependent GAR transformylase activity" EXACT [] synonym: "GAR transformylase 2" RELATED [] synonym: "GART 2" RELATED [] xref: MetaCyc:GARTRANSFORMYL2-RXN +xref: RHEA:24829 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] @@ -254136,6 +254213,7 @@ def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + prop synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT [] synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT [] xref: MetaCyc:RXN0-268 +xref: RHEA:28010 is_a: GO:0008410 ! CoA-transferase activity [Term] @@ -254157,6 +254235,7 @@ namespace: molecular_function def: "Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O." [PMID:16086104, PMID:16158287] xref: EC:1.14.15.9 xref: MetaCyc:RXN-10670 +xref: RHEA:33027 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] @@ -254229,6 +254308,7 @@ synonym: "B0503" RELATED [] synonym: "SelU" RELATED [] synonym: "YbbB" RELATED [] xref: MetaCyc:RXN0-2281 +xref: RHEA:42716 is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -254299,6 +254379,7 @@ synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase a synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT [] xref: EC:2.1.1.250 xref: MetaCyc:RXN-8102 +xref: RHEA:39287 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -254332,6 +254413,7 @@ namespace: molecular_function def: "Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH." [PMID:10612726, PMID:2803248] synonym: "ValDH" RELATED [] xref: EC:1.4.1.23 +xref: RHEA:30763 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] @@ -254508,6 +254590,7 @@ synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT [] synonym: "MtmB" RELATED [] xref: EC:2.1.1.248 xref: MetaCyc:RXN-8098 +xref: RHEA:26059 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -254590,7 +254673,6 @@ namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200] comment: This term was made obsolete because it represents a gene product. synonym: "cyanophycinase activity" EXACT [] -xref: EC:3 is_obsolete: true replaced_by: GO:0008236 @@ -254636,6 +254718,7 @@ synonym: "HHED aldolase activity" EXACT [] synonym: "HpaI" RELATED [] synonym: "HpcH" RELATED [] xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN +xref: RHEA:25788 is_a: GO:0016832 ! aldehyde-lyase activity [Term] @@ -254650,6 +254733,7 @@ synonym: "indole-3-acetamide hydrolase activity" EXACT [] synonym: "Tms2" RELATED [] xref: EC:3.5.1.4 xref: MetaCyc:G-5841 +xref: RHEA:45048 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -254703,6 +254787,7 @@ synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT [] synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT [] synonym: "NAGSA dehydrogenase activity" BROAD [] xref: MetaCyc:RXN-5183 +xref: RHEA:41948 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -254714,6 +254799,7 @@ comment: This function is part of the pipecolate pathway of lysine catabolism. synonym: "AmaB" RELATED [] synonym: "PIPOX" RELATED [] xref: MetaCyc:RXN-8162 +xref: RHEA:49476 is_a: GO:0016491 ! oxidoreductase activity [Term] @@ -254739,6 +254825,7 @@ def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-C synonym: "NifJ" RELATED [] synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT [] xref: MetaCyc:PYFLAVOXRE-RXN +xref: RHEA:44140 is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] @@ -254780,6 +254867,7 @@ synonym: "DtaAS" RELATED [] synonym: "low-specificity D-threonine aldolase" NARROW [] xref: EC:4.1.2.42 xref: MetaCyc:4.1.2.42-RXN +xref: RHEA:15257 is_a: GO:0016832 ! aldehyde-lyase activity [Term] @@ -254803,6 +254891,7 @@ synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXAC synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT [] xref: EC:1.2.1.3 xref: MetaCyc:RXN-3443 +xref: RHEA:25294 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -254877,6 +254966,7 @@ synonym: "ACS" RELATED [EC:2.3.1.169] synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT [] xref: EC:2.3.1.169 xref: MetaCyc:ACETYLSYNCLTH-RXN +xref: RHEA:45212 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -254901,11 +254991,12 @@ is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group id: GO:0043886 name: structural constituent of carboxysome namespace: molecular_function -def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide." [GOC:jl] +def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO(2)." [GOC:jl, PMID:28934381] is_a: GO:0005198 ! structural molecule activity intersection_of: GO:0005198 ! structural molecule activity intersection_of: occurs_in GO:0031470 ! carboxysome relationship: occurs_in GO:0031470 ! carboxysome +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19743 xsd:anyURI [Term] id: GO:0043887 @@ -255133,15 +255224,17 @@ relationship: positively_regulates GO:0051704 ! multi-organism process [Term] id: GO:0043903 -name: regulation of interspecies interactions between organisms +name: regulation of symbiotic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl] +comment: regulation of interspecies interactions between organisms +synonym: "regulation of interspecies interactions between organisms" BROAD [] synonym: "regulation of symbiosis, encompassing mutualism through parasitism" RELATED [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044403 ! symbiotic process relationship: regulates GO:0044403 ! symbiotic process -property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19222 xsd:anyURI +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19028 xsd:anyURI [Term] id: GO:0043904 @@ -255152,6 +255245,7 @@ synonym: "IPL" EXACT [] synonym: "isochorismate-pyruvate lyase activity" EXACT [] xref: EC:4.2.99.21 xref: MetaCyc:RXN-1981 +xref: RHEA:27874 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] @@ -255354,7 +255448,7 @@ name: suramin binding namespace: molecular_function def: "Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [GOC:jl, Wikipedia:Suramin] synonym: "Germanin binding" EXACT [] -is_a: GO:0008144 ! drug binding +is_a: GO:0033218 ! amide binding is_a: GO:0043168 ! anion binding is_a: GO:0043177 ! organic acid binding is_a: GO:0097159 ! organic cyclic compound binding @@ -255707,6 +255801,7 @@ synonym: "AMP-dependent synthetase and ligase" BROAD [] synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD [] synonym: "enoyl-CoA hydratase/isomerase" BROAD [] xref: EC:6.2.1.36 +xref: RHEA:26534 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity @@ -255724,6 +255819,7 @@ synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BRO synonym: "enoyl-CoA hydratase/isomerase" BROAD [] xref: EC:4.2.1.116 xref: MetaCyc:RXN-6383 +xref: RHEA:26518 is_a: GO:0016836 ! hydro-lyase activity [Term] @@ -255756,6 +255852,7 @@ synonym: "acrylyl-CoA reductase (NADH)" EXACT [] synonym: "propionyl-CoA dehydrogenase" EXACT [] xref: EC:1.3.99.3 xref: MetaCyc:RXN-8568 +xref: RHEA:34471 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -255784,6 +255881,7 @@ synonym: "succinyl-CoA:(R)-citramalate CoA transferase activity" EXACT [] synonym: "succinyl-CoA:R-citramalate CoA transferase" EXACT [] xref: EC:2.8.3.20 xref: MetaCyc:RXN-8966 +xref: RHEA:38279 is_a: GO:0008410 ! CoA-transferase activity [Term] @@ -257358,11 +257456,11 @@ creation_date: 2009-08-04T03:36:02Z [Term] id: GO:0044133 -name: growth of symbiont on or near host +name: obsolete growth of symbiont on or near host namespace: biological_process -def: "The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators] -comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'development of symbiont on or near host ; GO:0044132'. -is_a: GO:0044110 ! growth involved in symbiotic interaction +def: "OBSOLETE. The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +is_obsolete: true created_by: jl creation_date: 2009-08-04T03:36:49Z @@ -257489,7 +257587,7 @@ def: "Any process that modulates the frequency, rate or extent of the progressio comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'. synonym: "modulation of development of symbiont during interaction with host" RELATED [GOC:dph] is_a: GO:0043900 ! regulation of multi-organism process -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0044115 ! development of symbiont involved in interaction with host created_by: jl @@ -260732,10 +260830,9 @@ creation_date: 2012-01-12T03:14:19Z id: GO:0044466 name: glutaryl-CoA hydrolase activity namespace: molecular_function -def: "Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate." [GOC:pm, PMID:16141203, RHEA:13389] +def: "Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate." [GOC:pm, PMID:16141203] synonym: "glutaryl-CoA thioesterase activity" EXACT [] -xref: EC:1.3.8.6 -xref: RHEA:13389 +xref: EC:3.1.2.3 is_a: GO:0047617 ! acyl-CoA hydrolase activity created_by: jl creation_date: 2012-01-17T04:16:43Z @@ -262010,7 +262107,6 @@ id: GO:0044589 name: pectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with pectin." [GOC:mengo_curators, GOC:tt] -is_a: GO:0008144 ! drug binding is_a: GO:0048028 ! galacturonan binding created_by: jl creation_date: 2012-04-26T01:26:56Z @@ -262022,7 +262118,7 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691] synonym: "FeMo co binding" EXACT [] synonym: "FeMoco binding" EXACT [] -is_a: GO:0048037 ! cofactor binding +is_a: GO:0005488 ! binding created_by: jl creation_date: 2012-04-26T02:27:39Z @@ -262055,7 +262151,7 @@ synonym: "FeMoco biosynthetic process" EXACT [] synonym: "iron molybdenum cofactor assembly" EXACT [] synonym: "iron molybdenum cofactor biosynthesis" EXACT [] synonym: "iron molybdenum cofactor biosynthetic process" EXACT [] -is_a: GO:0051188 ! cofactor biosynthetic process +is_a: GO:0016226 ! iron-sulfur cluster assembly created_by: jl creation_date: 2012-04-26T04:01:53Z @@ -262088,6 +262184,7 @@ namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-10 = S-adenosyl-L-homocysteine + ubiquinol-10." [PMID:10777520] xref: MetaCyc:RXN-9237 xref: Reactome:R-HSA-2162186 "DeMQ10H2 is methylated to Q10H2 by COQ3" +xref: RHEA:44412 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0061542 ! 3-demethylubiquinol-n 3-O-methyltransferase activity created_by: jl @@ -262115,7 +262212,6 @@ def: "The chemical reactions and pathways involving doxorubicin, an anthracyclin is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0016137 ! glycoside metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -262255,7 +262351,6 @@ def: "Enables the directed movement of flavine mononucleotide (FMN) from one sid synonym: "flavine mononucleotide transmembrane transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015215 ! nucleotide transmembrane transporter activity -is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity created_by: jl creation_date: 2012-05-30T03:09:19Z @@ -263033,6 +263128,7 @@ name: dihydromethanopterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP." [GOC:mengo_curators, PMID:15028691] xref: EC:1.5.99.15 +xref: RHEA:42804 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor relationship: part_of GO:2001118 ! tetrahydromethanopterin biosynthetic process created_by: jl @@ -263455,7 +263551,7 @@ name: acid-sensing ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex." [GOC:jl] synonym: "ASIC activity" EXACT [] -xref: Reactome:R-HSA-2671885 "ASICs transport extracellular Na+ to cytosol" +xref: Reactome:R-HSA-2671885 "ASIC trimers:H+ transport extracellular Na+ to cytosol" xref: Wikipedia:Acid-sensing_ion_channel is_a: GO:0015280 ! ligand-gated sodium channel activity created_by: jl @@ -264819,12 +264915,16 @@ creation_date: 2014-11-25T16:30:30Z [Term] id: GO:0044875 -name: gamma-glutamyl hercynylcysteine sulfoxide synthase +name: gamma-glutamyl hercynylcysteine sulfoxide synthase activity namespace: molecular_function -def: "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O." [GOC:jl, PMID:24828577] +def: "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O." [GOC:jl, PMID:24828577, RHEA:42672] synonym: "gamma-glutamyl hercynylcysteine S-oxide synthase" EXACT [GOC:dph] -xref: EC:1.14.99 +synonym: "gamma-glutamyl hercynylcysteine sulfoxide synthase" EXACT [] +xref: EC:1.14.99.50 +xref: RHEA:42672 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +relationship: part_of GO:0052704 ! ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/11163 xsd:anyURI created_by: jl creation_date: 2014-12-15T11:44:54Z @@ -265095,7 +265195,7 @@ def: "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and comment: This term was made obsolete because it represents a gene product. synonym: "peptidyl-glutamyl peptide hydrolyzing enzyme activity" EXACT [] is_obsolete: true -replaced_by: GO:0070011 +replaced_by: GO:0008233 [Term] id: GO:0045025 @@ -265601,21 +265701,6 @@ intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019079 ! viral genome replication relationship: negatively_regulates GO:0019079 ! viral genome replication -[Term] -id: GO:0045072 -name: regulation of interferon-gamma biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] -synonym: "regulation of interferon-gamma anabolism" EXACT [] -synonym: "regulation of interferon-gamma biosynthesis" EXACT [] -synonym: "regulation of interferon-gamma formation" EXACT [] -synonym: "regulation of interferon-gamma synthesis" EXACT [] -is_a: GO:0032649 ! regulation of interferon-gamma production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042095 ! interferon-gamma biosynthetic process -relationship: regulates GO:0042095 ! interferon-gamma biosynthetic process - [Term] id: GO:0045073 name: regulation of chemokine biosynthetic process @@ -265631,98 +265716,6 @@ intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042033 ! chemokine biosynthetic process relationship: regulates GO:0042033 ! chemokine biosynthetic process -[Term] -id: GO:0045074 -name: regulation of interleukin-10 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] -synonym: "regulation of IL-10 biosynthesis" EXACT [] -synonym: "regulation of IL-10 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-10 anabolism" EXACT [] -synonym: "regulation of interleukin-10 biosynthesis" EXACT [] -synonym: "regulation of interleukin-10 formation" EXACT [] -synonym: "regulation of interleukin-10 synthesis" EXACT [] -is_a: GO:0032653 ! regulation of interleukin-10 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042091 ! interleukin-10 biosynthetic process -relationship: regulates GO:0042091 ! interleukin-10 biosynthetic process - -[Term] -id: GO:0045075 -name: regulation of interleukin-12 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] -synonym: "regulation of IL-12 biosynthesis" EXACT [] -synonym: "regulation of IL-12 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-12 anabolism" EXACT [] -synonym: "regulation of interleukin-12 biosynthesis" EXACT [] -synonym: "regulation of interleukin-12 formation" EXACT [] -synonym: "regulation of interleukin-12 synthesis" EXACT [] -is_a: GO:0032655 ! regulation of interleukin-12 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042090 ! interleukin-12 biosynthetic process -relationship: regulates GO:0042090 ! interleukin-12 biosynthetic process - -[Term] -id: GO:0045076 -name: regulation of interleukin-2 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] -synonym: "regulation of IL-2 biosynthesis" EXACT [] -synonym: "regulation of IL-2 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-2 anabolism" EXACT [] -synonym: "regulation of interleukin-2 biosynthesis" EXACT [] -synonym: "regulation of interleukin-2 formation" EXACT [] -synonym: "regulation of interleukin-2 synthesis" EXACT [] -is_a: GO:0032663 ! regulation of interleukin-2 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042094 ! interleukin-2 biosynthetic process -relationship: regulates GO:0042094 ! interleukin-2 biosynthetic process - -[Term] -id: GO:0045077 -name: negative regulation of interferon-gamma biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] -synonym: "down regulation of interferon-gamma biosynthetic process" EXACT [] -synonym: "down-regulation of interferon-gamma biosynthetic process" EXACT [] -synonym: "downregulation of interferon-gamma biosynthetic process" EXACT [] -synonym: "inhibition of interferon-gamma biosynthetic process" NARROW [] -synonym: "negative regulation of interferon-gamma anabolism" EXACT [] -synonym: "negative regulation of interferon-gamma biosynthesis" EXACT [] -synonym: "negative regulation of interferon-gamma formation" EXACT [] -synonym: "negative regulation of interferon-gamma synthesis" EXACT [] -is_a: GO:0032689 ! negative regulation of interferon-gamma production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process -relationship: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process - -[Term] -id: GO:0045078 -name: positive regulation of interferon-gamma biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] -synonym: "activation of interferon-gamma biosynthetic process" NARROW [] -synonym: "positive regulation of interferon-gamma anabolism" EXACT [] -synonym: "positive regulation of interferon-gamma biosynthesis" EXACT [] -synonym: "positive regulation of interferon-gamma formation" EXACT [] -synonym: "positive regulation of interferon-gamma synthesis" EXACT [] -synonym: "stimulation of interferon-gamma biosynthetic process" NARROW [] -synonym: "up regulation of interferon-gamma biosynthetic process" EXACT [] -synonym: "up-regulation of interferon-gamma biosynthetic process" EXACT [] -synonym: "upregulation of interferon-gamma biosynthetic process" EXACT [] -is_a: GO:0032729 ! positive regulation of interferon-gamma production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process -relationship: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process - [Term] id: GO:0045079 name: negative regulation of chemokine biosynthetic process @@ -265764,141 +265757,6 @@ intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042033 ! chemokine biosynthetic process relationship: positively_regulates GO:0042033 ! chemokine biosynthetic process -[Term] -id: GO:0045081 -name: negative regulation of interleukin-10 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] -synonym: "down regulation of interleukin-10 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-10 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-10 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-10 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-10 biosynthesis" EXACT [] -synonym: "negative regulation of IL-10 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-10 anabolism" EXACT [] -synonym: "negative regulation of interleukin-10 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-10 formation" EXACT [] -synonym: "negative regulation of interleukin-10 synthesis" EXACT [] -is_a: GO:0032693 ! negative regulation of interleukin-10 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process -relationship: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process - -[Term] -id: GO:0045082 -name: positive regulation of interleukin-10 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] -synonym: "activation of interleukin-10 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-10 biosynthesis" EXACT [] -synonym: "positive regulation of IL-10 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-10 anabolism" EXACT [] -synonym: "positive regulation of interleukin-10 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-10 formation" EXACT [] -synonym: "positive regulation of interleukin-10 synthesis" EXACT [] -synonym: "stimulation of interleukin-10 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-10 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-10 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-10 biosynthetic process" EXACT [] -is_a: GO:0032733 ! positive regulation of interleukin-10 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process -relationship: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process - -[Term] -id: GO:0045083 -name: negative regulation of interleukin-12 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] -synonym: "down regulation of interleukin-12 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-12 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-12 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-12 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-12 biosynthesis" EXACT [] -synonym: "negative regulation of IL-12 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-12 anabolism" EXACT [] -synonym: "negative regulation of interleukin-12 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-12 formation" EXACT [] -synonym: "negative regulation of interleukin-12 synthesis" EXACT [] -is_a: GO:0032695 ! negative regulation of interleukin-12 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process -relationship: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process - -[Term] -id: GO:0045084 -name: positive regulation of interleukin-12 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] -synonym: "activation of interleukin-12 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-12 biosynthesis" EXACT [] -synonym: "positive regulation of IL-12 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-12 anabolism" EXACT [] -synonym: "positive regulation of interleukin-12 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-12 formation" EXACT [] -synonym: "positive regulation of interleukin-12 synthesis" EXACT [] -synonym: "stimulation of interleukin-12 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-12 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-12 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-12 biosynthetic process" EXACT [] -is_a: GO:0032735 ! positive regulation of interleukin-12 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process -relationship: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process - -[Term] -id: GO:0045085 -name: negative regulation of interleukin-2 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] -synonym: "down regulation of interleukin-2 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-2 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-2 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-2 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-2 biosynthesis" EXACT [] -synonym: "negative regulation of IL-2 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-2 anabolism" EXACT [] -synonym: "negative regulation of interleukin-2 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-2 formation" EXACT [] -synonym: "negative regulation of interleukin-2 synthesis" EXACT [] -is_a: GO:0032703 ! negative regulation of interleukin-2 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process -relationship: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process - -[Term] -id: GO:0045086 -name: positive regulation of interleukin-2 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] -synonym: "activation of interleukin-2 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-2 biosynthesis" EXACT [] -synonym: "positive regulation of IL-2 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-2 anabolism" EXACT [] -synonym: "positive regulation of interleukin-2 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-2 formation" EXACT [] -synonym: "positive regulation of interleukin-2 synthesis" EXACT [] -synonym: "stimulation of interleukin-2 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-2 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-2 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-2 biosynthetic process" EXACT [] -is_a: GO:0032743 ! positive regulation of interleukin-2 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process -relationship: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process - [Term] id: GO:0045087 name: innate immune response @@ -266458,8 +266316,9 @@ replaced_by: GO:0046688 id: GO:0045140 name: inositol phosphoceramide synthase activity namespace: molecular_function -def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [MetaCyc:RXN3O-581, PMID:9405490, PMID:9614099] +def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol." [PMID:9405490, PMID:9614099] synonym: "IPC synthase activity" EXACT [] +xref: EC:2.7.1.227 xref: MetaCyc:RXN3O-581 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -266809,7 +266668,7 @@ synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" EXACT [EC:1. xref: EC:1.8.5.1 xref: KEGG_REACTION:R01108 xref: MetaCyc:1.8.5.1-RXN -xref: Reactome:R-HSA-198813 "2xGSTOs reduce DHvitC to VitC" +xref: Reactome:R-HSA-198813 "GSTO dimers reduce DeHA to AscH-" xref: RHEA:24424 is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity @@ -266959,17 +266818,16 @@ relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep [Term] id: GO:0045189 -name: connective tissue growth factor biosynthetic process +name: obsolete connective tissue growth factor biosynthetic process namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [http://www.copewithcytokines.de] +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [GOC:curators] +comment: This term was obsoleted because it represent translation of a gene product, not a specific process. synonym: "connective tissue growth factor anabolism" EXACT [] synonym: "connective tissue growth factor biosynthesis" EXACT [] synonym: "connective tissue growth factor formation" EXACT [] synonym: "connective tissue growth factor synthesis" EXACT [] synonym: "CTGF biosynthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032601 ! connective tissue growth factor production +is_obsolete: true [Term] id: GO:0045190 @@ -267289,7 +267147,7 @@ is_a: GO:0034334 ! adherens junction maintenance [Term] id: GO:0045219 -name: regulation of FasL biosynthetic process +name: regulation of FasL production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] synonym: "regulation of FasL anabolism" EXACT [] @@ -267303,12 +267161,13 @@ relationship: regulates GO:0045210 ! FasL biosynthetic process [Term] id: GO:0045220 -name: positive regulation of FasL biosynthetic process +name: positive regulation of FasL production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] synonym: "activation of FasL biosynthetic process" NARROW [] synonym: "positive regulation of FasL anabolism" EXACT [] synonym: "positive regulation of FasL biosynthesis" EXACT [] +synonym: "positive regulation of FasL biosynthetic process" EXACT [] synonym: "positive regulation of FasL formation" EXACT [] synonym: "positive regulation of FasL synthesis" EXACT [] synonym: "stimulation of FasL biosynthetic process" NARROW [] @@ -267316,14 +267175,14 @@ synonym: "up regulation of FasL biosynthetic process" EXACT [] synonym: "up-regulation of FasL biosynthetic process" EXACT [] synonym: "upregulation of FasL biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process -is_a: GO:0045219 ! regulation of FasL biosynthetic process +is_a: GO:0045219 ! regulation of FasL production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045210 ! FasL biosynthetic process relationship: positively_regulates GO:0045210 ! FasL biosynthetic process [Term] id: GO:0045221 -name: negative regulation of FasL biosynthetic process +name: negative regulation of FasL production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] synonym: "down regulation of FasL biosynthetic process" EXACT [] @@ -267332,10 +267191,11 @@ synonym: "downregulation of FasL biosynthetic process" EXACT [] synonym: "inhibition of FasL biosynthetic process" NARROW [] synonym: "negative regulation of FasL anabolism" EXACT [] synonym: "negative regulation of FasL biosynthesis" EXACT [] +synonym: "negative regulation of FasL biosynthetic process" EXACT [] synonym: "negative regulation of FasL formation" EXACT [] synonym: "negative regulation of FasL synthesis" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process -is_a: GO:0045219 ! regulation of FasL biosynthetic process +is_a: GO:0045219 ! regulation of FasL production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045210 ! FasL biosynthetic process relationship: negatively_regulates GO:0045210 ! FasL biosynthetic process @@ -267353,11 +267213,12 @@ is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0045223 -name: regulation of CD4 biosynthetic process +name: regulation of CD4 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] synonym: "regulation of CD4 anabolism" EXACT [] synonym: "regulation of CD4 biosynthesis" EXACT [] +synonym: "regulation of CD4 biosynthetic process" EXACT [] synonym: "regulation of CD4 formation" EXACT [] synonym: "regulation of CD4 synthesis" EXACT [] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process @@ -267367,12 +267228,13 @@ relationship: regulates GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0045224 -name: positive regulation of CD4 biosynthetic process +name: positive regulation of CD4 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] synonym: "activation of CD4 biosynthetic process" NARROW [] synonym: "positive regulation of CD4 anabolism" EXACT [] synonym: "positive regulation of CD4 biosynthesis" EXACT [] +synonym: "positive regulation of CD4 biosynthetic process" EXACT [] synonym: "positive regulation of CD4 formation" EXACT [] synonym: "positive regulation of CD4 synthesis" EXACT [] synonym: "stimulation of CD4 biosynthetic process" NARROW [] @@ -267380,14 +267242,14 @@ synonym: "up regulation of CD4 biosynthetic process" EXACT [] synonym: "up-regulation of CD4 biosynthetic process" EXACT [] synonym: "upregulation of CD4 biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process -is_a: GO:0045223 ! regulation of CD4 biosynthetic process +is_a: GO:0045223 ! regulation of CD4 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045222 ! CD4 biosynthetic process relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process [Term] id: GO:0045225 -name: negative regulation of CD4 biosynthetic process +name: negative regulation of CD4 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] synonym: "down regulation of CD4 biosynthetic process" EXACT [] @@ -267396,10 +267258,11 @@ synonym: "downregulation of CD4 biosynthetic process" EXACT [] synonym: "inhibition of CD4 biosynthetic process" NARROW [] synonym: "negative regulation of CD4 anabolism" EXACT [] synonym: "negative regulation of CD4 biosynthesis" EXACT [] +synonym: "negative regulation of CD4 biosynthetic process" EXACT [] synonym: "negative regulation of CD4 formation" EXACT [] synonym: "negative regulation of CD4 synthesis" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process -is_a: GO:0045223 ! regulation of CD4 biosynthetic process +is_a: GO:0045223 ! regulation of CD4 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045222 ! CD4 biosynthetic process relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process @@ -268686,49 +268549,6 @@ intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045342 ! MHC class II biosynthetic process relationship: positively_regulates GO:0045342 ! MHC class II biosynthetic process -[Term] -id: GO:0045349 -name: interferon-alpha biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] -synonym: "IFN-alpha biosynthesis" EXACT [] -synonym: "IFN-alpha biosynthetic process" EXACT [] -synonym: "interferon-alpha anabolism" EXACT [] -synonym: "interferon-alpha biosynthesis" EXACT [] -synonym: "interferon-alpha formation" EXACT [] -synonym: "interferon-alpha synthesis" EXACT [] -is_a: GO:0045351 ! type I interferon biosynthetic process -relationship: part_of GO:0032607 ! interferon-alpha production - -[Term] -id: GO:0045350 -name: interferon-beta biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] -synonym: "IFN-beta biosynthesis" EXACT [] -synonym: "IFN-beta biosynthetic process" EXACT [] -synonym: "IFNB biosynthetic process" EXACT [GOC:mah] -synonym: "interferon-beta anabolism" EXACT [] -synonym: "interferon-beta biosynthesis" EXACT [] -synonym: "interferon-beta formation" EXACT [] -synonym: "interferon-beta synthesis" EXACT [] -is_a: GO:0045351 ! type I interferon biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032608 ! interferon-beta production - -[Term] -id: GO:0045351 -name: type I interferon biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add] -synonym: "interferon type I biosynthetic process" EXACT [] -synonym: "type I interferon anabolism" EXACT [] -synonym: "type I interferon biosynthesis" EXACT [] -synonym: "type I interferon formation" EXACT [] -synonym: "type I interferon synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -relationship: part_of GO:0032606 ! type I interferon production - [Term] id: GO:0045352 name: interleukin-1 type I receptor antagonist activity @@ -268745,1414 +268565,6 @@ def: "Blocks the binding of interleukin-1 to interleukin-1 type II receptors." [ synonym: "IL-1ra type II" EXACT [] is_a: GO:0005152 ! interleukin-1 receptor antagonist activity -[Term] -id: GO:0045354 -name: regulation of interferon-alpha biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] -synonym: "regulation of interferon-alpha anabolism" EXACT [] -synonym: "regulation of interferon-alpha biosynthesis" EXACT [] -synonym: "regulation of interferon-alpha formation" EXACT [] -synonym: "regulation of interferon-alpha synthesis" EXACT [] -is_a: GO:0032647 ! regulation of interferon-alpha production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0045349 ! interferon-alpha biosynthetic process -relationship: regulates GO:0045349 ! interferon-alpha biosynthetic process - -[Term] -id: GO:0045355 -name: negative regulation of interferon-alpha biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] -synonym: "down regulation of interferon-alpha biosynthetic process" EXACT [] -synonym: "down-regulation of interferon-alpha biosynthetic process" EXACT [] -synonym: "downregulation of interferon-alpha biosynthetic process" EXACT [] -synonym: "inhibition of interferon-alpha biosynthetic process" NARROW [] -synonym: "negative regulation of interferon-alpha anabolism" EXACT [] -synonym: "negative regulation of interferon-alpha biosynthesis" EXACT [] -synonym: "negative regulation of interferon-alpha formation" EXACT [] -synonym: "negative regulation of interferon-alpha synthesis" EXACT [] -is_a: GO:0032687 ! negative regulation of interferon-alpha production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process -relationship: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process - -[Term] -id: GO:0045356 -name: positive regulation of interferon-alpha biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] -synonym: "activation of interferon-alpha biosynthetic process" NARROW [] -synonym: "positive regulation of interferon-alpha anabolism" EXACT [] -synonym: "positive regulation of interferon-alpha biosynthesis" EXACT [] -synonym: "positive regulation of interferon-alpha formation" EXACT [] -synonym: "positive regulation of interferon-alpha synthesis" EXACT [] -synonym: "stimulation of interferon-alpha biosynthetic process" NARROW [] -synonym: "up regulation of interferon-alpha biosynthetic process" EXACT [] -synonym: "up-regulation of interferon-alpha biosynthetic process" EXACT [] -synonym: "upregulation of interferon-alpha biosynthetic process" EXACT [] -is_a: GO:0032727 ! positive regulation of interferon-alpha production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process -relationship: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process - -[Term] -id: GO:0045357 -name: regulation of interferon-beta biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] -synonym: "regulation of interferon-beta anabolism" EXACT [] -synonym: "regulation of interferon-beta biosynthesis" EXACT [] -synonym: "regulation of interferon-beta formation" EXACT [] -synonym: "regulation of interferon-beta synthesis" EXACT [] -is_a: GO:0032648 ! regulation of interferon-beta production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0045350 ! interferon-beta biosynthetic process -relationship: regulates GO:0045350 ! interferon-beta biosynthetic process - -[Term] -id: GO:0045358 -name: negative regulation of interferon-beta biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] -synonym: "down regulation of interferon-beta biosynthetic process" EXACT [] -synonym: "down-regulation of interferon-beta biosynthetic process" EXACT [] -synonym: "downregulation of interferon-beta biosynthetic process" EXACT [] -synonym: "inhibition of interferon-beta biosynthetic process" NARROW [] -synonym: "negative regulation of interferon-beta anabolism" EXACT [] -synonym: "negative regulation of interferon-beta biosynthesis" EXACT [] -synonym: "negative regulation of interferon-beta formation" EXACT [] -synonym: "negative regulation of interferon-beta synthesis" EXACT [] -is_a: GO:0032688 ! negative regulation of interferon-beta production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process -relationship: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process - -[Term] -id: GO:0045359 -name: positive regulation of interferon-beta biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] -synonym: "activation of interferon-beta biosynthetic process" NARROW [] -synonym: "positive regulation of interferon-beta anabolism" EXACT [] -synonym: "positive regulation of interferon-beta biosynthesis" EXACT [] -synonym: "positive regulation of interferon-beta formation" EXACT [] -synonym: "positive regulation of interferon-beta synthesis" EXACT [] -synonym: "stimulation of interferon-beta biosynthetic process" NARROW [] -synonym: "up regulation of interferon-beta biosynthetic process" EXACT [] -synonym: "up-regulation of interferon-beta biosynthetic process" EXACT [] -synonym: "upregulation of interferon-beta biosynthetic process" EXACT [] -is_a: GO:0032728 ! positive regulation of interferon-beta production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0045350 ! interferon-beta biosynthetic process -relationship: positively_regulates GO:0045350 ! interferon-beta biosynthetic process - -[Term] -id: GO:0045360 -name: regulation of interleukin-1 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] -synonym: "regulation of IL-1 biosynthesis" EXACT [] -synonym: "regulation of IL-1 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-1 anabolism" EXACT [] -synonym: "regulation of interleukin-1 biosynthesis" EXACT [] -synonym: "regulation of interleukin-1 formation" EXACT [] -synonym: "regulation of interleukin-1 synthesis" EXACT [] -is_a: GO:0032652 ! regulation of interleukin-1 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042222 ! interleukin-1 biosynthetic process -relationship: regulates GO:0042222 ! interleukin-1 biosynthetic process - -[Term] -id: GO:0045361 -name: negative regulation of interleukin-1 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] -synonym: "down regulation of interleukin-1 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-1 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-1 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-1 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-1 biosynthesis" EXACT [] -synonym: "negative regulation of IL-1 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-1 anabolism" EXACT [] -synonym: "negative regulation of interleukin-1 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-1 formation" EXACT [] -synonym: "negative regulation of interleukin-1 synthesis" EXACT [] -is_a: GO:0032692 ! negative regulation of interleukin-1 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process -relationship: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process - -[Term] -id: GO:0045362 -name: positive regulation of interleukin-1 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] -synonym: "activation of interleukin-1 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-1 biosynthesis" EXACT [] -synonym: "positive regulation of IL-1 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-1 anabolism" EXACT [] -synonym: "positive regulation of interleukin-1 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-1 formation" EXACT [] -synonym: "positive regulation of interleukin-1 synthesis" EXACT [] -synonym: "stimulation of interleukin-1 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-1 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-1 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-1 biosynthetic process" EXACT [] -is_a: GO:0032732 ! positive regulation of interleukin-1 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process -relationship: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process - -[Term] -id: GO:0045363 -name: regulation of interleukin-11 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] -synonym: "regulation of IL-11 biosynthesis" EXACT [] -synonym: "regulation of IL-11 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-11 anabolism" EXACT [] -synonym: "regulation of interleukin-11 biosynthesis" EXACT [] -synonym: "regulation of interleukin-11 formation" EXACT [] -synonym: "regulation of interleukin-11 synthesis" EXACT [] -is_a: GO:0032654 ! regulation of interleukin-11 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042230 ! interleukin-11 biosynthetic process -relationship: regulates GO:0042230 ! interleukin-11 biosynthetic process - -[Term] -id: GO:0045364 -name: negative regulation of interleukin-11 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] -synonym: "down regulation of interleukin-11 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-11 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-11 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-11 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-11 biosynthesis" EXACT [] -synonym: "negative regulation of IL-11 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-11 anabolism" EXACT [] -synonym: "negative regulation of interleukin-11 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-11 formation" EXACT [] -synonym: "negative regulation of interleukin-11 synthesis" EXACT [] -is_a: GO:0032694 ! negative regulation of interleukin-11 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process -relationship: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process - -[Term] -id: GO:0045365 -name: positive regulation of interleukin-11 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] -synonym: "activation of interleukin-11 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-11 biosynthesis" EXACT [] -synonym: "positive regulation of IL-11 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-11 anabolism" EXACT [] -synonym: "positive regulation of interleukin-11 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-11 formation" EXACT [] -synonym: "positive regulation of interleukin-11 synthesis" EXACT [] -synonym: "stimulation of interleukin-11 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-11 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-11 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-11 biosynthetic process" EXACT [] -is_a: GO:0032734 ! positive regulation of interleukin-11 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process -relationship: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process - -[Term] -id: GO:0045366 -name: regulation of interleukin-13 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] -synonym: "regulation of IL-13 biosynthesis" EXACT [] -synonym: "regulation of IL-13 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-13 anabolism" EXACT [] -synonym: "regulation of interleukin-13 biosynthesis" EXACT [] -synonym: "regulation of interleukin-13 formation" EXACT [] -synonym: "regulation of interleukin-13 synthesis" EXACT [] -is_a: GO:0032656 ! regulation of interleukin-13 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042231 ! interleukin-13 biosynthetic process -relationship: regulates GO:0042231 ! interleukin-13 biosynthetic process - -[Term] -id: GO:0045367 -name: negative regulation of interleukin-13 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] -synonym: "down regulation of interleukin-13 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-13 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-13 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-13 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-13 biosynthesis" EXACT [] -synonym: "negative regulation of IL-13 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-13 anabolism" EXACT [] -synonym: "negative regulation of interleukin-13 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-13 formation" EXACT [] -synonym: "negative regulation of interleukin-13 synthesis" EXACT [] -is_a: GO:0032696 ! negative regulation of interleukin-13 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process -relationship: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process - -[Term] -id: GO:0045368 -name: positive regulation of interleukin-13 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] -synonym: "activation of interleukin-13 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-13 biosynthesis" EXACT [] -synonym: "positive regulation of IL-13 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-13 anabolism" EXACT [] -synonym: "positive regulation of interleukin-13 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-13 formation" EXACT [] -synonym: "positive regulation of interleukin-13 synthesis" EXACT [] -synonym: "stimulation of interleukin-13 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-13 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-13 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-13 biosynthetic process" EXACT [] -is_a: GO:0032736 ! positive regulation of interleukin-13 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process -relationship: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process - -[Term] -id: GO:0045369 -name: regulation of interleukin-14 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] -synonym: "regulation of IL-14 biosynthesis" EXACT [] -synonym: "regulation of IL-14 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-14 anabolism" EXACT [] -synonym: "regulation of interleukin-14 biosynthesis" EXACT [] -synonym: "regulation of interleukin-14 formation" EXACT [] -synonym: "regulation of interleukin-14 synthesis" EXACT [] -is_a: GO:0032657 ! regulation of interleukin-14 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042232 ! interleukin-14 biosynthetic process -relationship: regulates GO:0042232 ! interleukin-14 biosynthetic process - -[Term] -id: GO:0045370 -name: negative regulation of interleukin-14 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] -synonym: "down regulation of interleukin-14 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-14 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-14 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-14 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-14 biosynthesis" EXACT [] -synonym: "negative regulation of IL-14 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-14 anabolism" EXACT [] -synonym: "negative regulation of interleukin-14 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-14 formation" EXACT [] -synonym: "negative regulation of interleukin-14 synthesis" EXACT [] -is_a: GO:0032697 ! negative regulation of interleukin-14 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process -relationship: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process - -[Term] -id: GO:0045371 -name: positive regulation of interleukin-14 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] -synonym: "activation of interleukin-14 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-14 biosynthesis" EXACT [] -synonym: "positive regulation of IL-14 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-14 anabolism" EXACT [] -synonym: "positive regulation of interleukin-14 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-14 formation" EXACT [] -synonym: "positive regulation of interleukin-14 synthesis" EXACT [] -synonym: "stimulation of interleukin-14 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-14 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-14 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-14 biosynthetic process" EXACT [] -is_a: GO:0032737 ! positive regulation of interleukin-14 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process -relationship: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process - -[Term] -id: GO:0045372 -name: regulation of interleukin-15 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] -synonym: "regulation of IL-15 biosynthesis" EXACT [] -synonym: "regulation of IL-15 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-15 anabolism" EXACT [] -synonym: "regulation of interleukin-15 biosynthesis" EXACT [] -synonym: "regulation of interleukin-15 formation" EXACT [] -synonym: "regulation of interleukin-15 synthesis" EXACT [] -is_a: GO:0032658 ! regulation of interleukin-15 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042233 ! interleukin-15 biosynthetic process -relationship: regulates GO:0042233 ! interleukin-15 biosynthetic process - -[Term] -id: GO:0045373 -name: negative regulation of interleukin-15 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] -synonym: "down regulation of interleukin-15 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-15 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-15 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-15 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-15 biosynthesis" EXACT [] -synonym: "negative regulation of IL-15 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-15 anabolism" EXACT [] -synonym: "negative regulation of interleukin-15 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-15 formation" EXACT [] -synonym: "negative regulation of interleukin-15 synthesis" EXACT [] -is_a: GO:0032698 ! negative regulation of interleukin-15 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process -relationship: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process - -[Term] -id: GO:0045374 -name: positive regulation of interleukin-15 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] -synonym: "activation of interleukin-15 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-15 biosynthesis" EXACT [] -synonym: "positive regulation of IL-15 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-15 anabolism" EXACT [] -synonym: "positive regulation of interleukin-15 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-15 formation" EXACT [] -synonym: "positive regulation of interleukin-15 synthesis" EXACT [] -synonym: "stimulation of interleukin-15 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-15 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-15 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-15 biosynthetic process" EXACT [] -is_a: GO:0032738 ! positive regulation of interleukin-15 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process -relationship: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process - -[Term] -id: GO:0045375 -name: regulation of interleukin-16 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] -synonym: "regulation of IL-16 biosynthesis" EXACT [] -synonym: "regulation of IL-16 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-16 anabolism" EXACT [] -synonym: "regulation of interleukin-16 biosynthesis" EXACT [] -synonym: "regulation of interleukin-16 formation" EXACT [] -synonym: "regulation of interleukin-16 synthesis" EXACT [] -is_a: GO:0032659 ! regulation of interleukin-16 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042234 ! interleukin-16 biosynthetic process -relationship: regulates GO:0042234 ! interleukin-16 biosynthetic process - -[Term] -id: GO:0045376 -name: negative regulation of interleukin-16 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] -synonym: "down regulation of interleukin-16 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-16 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-16 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-16 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-16 biosynthesis" EXACT [] -synonym: "negative regulation of IL-16 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-16 anabolism" EXACT [] -synonym: "negative regulation of interleukin-16 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-16 formation" EXACT [] -synonym: "negative regulation of interleukin-16 synthesis" EXACT [] -is_a: GO:0032699 ! negative regulation of interleukin-16 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process -relationship: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process - -[Term] -id: GO:0045377 -name: positive regulation of interleukin-16 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] -synonym: "activation of interleukin-16 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-16 biosynthesis" EXACT [] -synonym: "positive regulation of IL-16 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-16 anabolism" EXACT [] -synonym: "positive regulation of interleukin-16 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-16 formation" EXACT [] -synonym: "positive regulation of interleukin-16 synthesis" EXACT [] -synonym: "stimulation of interleukin-16 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-16 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-16 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-16 biosynthetic process" EXACT [] -is_a: GO:0032739 ! positive regulation of interleukin-16 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process -relationship: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process - -[Term] -id: GO:0045378 -name: regulation of interleukin-17 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators] -synonym: "regulation of IL-17 biosynthesis" EXACT [] -synonym: "regulation of IL-17 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-17 anabolism" EXACT [] -synonym: "regulation of interleukin-17 biosynthesis" EXACT [] -synonym: "regulation of interleukin-17 formation" EXACT [] -synonym: "regulation of interleukin-17 synthesis" EXACT [] -is_a: GO:0032660 ! regulation of interleukin-17 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042235 ! interleukin-17 biosynthetic process -relationship: regulates GO:0042235 ! interleukin-17 biosynthetic process - -[Term] -id: GO:0045379 -name: negative regulation of interleukin-17 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators] -synonym: "down regulation of interleukin-17 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-17 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-17 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-17 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-17 biosynthesis" EXACT [] -synonym: "negative regulation of IL-17 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-17 anabolism" EXACT [] -synonym: "negative regulation of interleukin-17 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-17 formation" EXACT [] -synonym: "negative regulation of interleukin-17 synthesis" EXACT [] -is_a: GO:0032700 ! negative regulation of interleukin-17 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process -relationship: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process - -[Term] -id: GO:0045380 -name: positive regulation of interleukin-17 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators] -synonym: "activation of interleukin-17 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-17 biosynthesis" EXACT [] -synonym: "positive regulation of IL-17 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-17 anabolism" EXACT [] -synonym: "positive regulation of interleukin-17 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-17 formation" EXACT [] -synonym: "positive regulation of interleukin-17 synthesis" EXACT [] -synonym: "stimulation of interleukin-17 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-17 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-17 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-17 biosynthetic process" EXACT [] -is_a: GO:0032740 ! positive regulation of interleukin-17 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process -relationship: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process - -[Term] -id: GO:0045381 -name: regulation of interleukin-18 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] -synonym: "regulation of IL-18 biosynthesis" EXACT [] -synonym: "regulation of IL-18 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-18 anabolism" EXACT [] -synonym: "regulation of interleukin-18 biosynthesis" EXACT [] -synonym: "regulation of interleukin-18 formation" EXACT [] -synonym: "regulation of interleukin-18 synthesis" EXACT [] -is_a: GO:0032661 ! regulation of interleukin-18 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042241 ! interleukin-18 biosynthetic process -relationship: regulates GO:0042241 ! interleukin-18 biosynthetic process - -[Term] -id: GO:0045382 -name: negative regulation of interleukin-18 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] -synonym: "down regulation of interleukin-18 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-18 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-18 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-18 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-18 biosynthesis" EXACT [] -synonym: "negative regulation of IL-18 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-18 anabolism" EXACT [] -synonym: "negative regulation of interleukin-18 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-18 formation" EXACT [] -synonym: "negative regulation of interleukin-18 synthesis" EXACT [] -is_a: GO:0032701 ! negative regulation of interleukin-18 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process -relationship: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process - -[Term] -id: GO:0045383 -name: positive regulation of interleukin-18 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] -synonym: "activation of interleukin-18 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-18 biosynthesis" EXACT [] -synonym: "positive regulation of IL-18 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-18 anabolism" EXACT [] -synonym: "positive regulation of interleukin-18 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-18 formation" EXACT [] -synonym: "positive regulation of interleukin-18 synthesis" EXACT [] -synonym: "stimulation of interleukin-18 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-18 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-18 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-18 biosynthetic process" EXACT [] -is_a: GO:0032741 ! positive regulation of interleukin-18 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process -relationship: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process - -[Term] -id: GO:0045384 -name: regulation of interleukin-19 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] -synonym: "regulation of IL-19 biosynthesis" EXACT [] -synonym: "regulation of IL-19 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-19 anabolism" EXACT [] -synonym: "regulation of interleukin-19 biosynthesis" EXACT [] -synonym: "regulation of interleukin-19 formation" EXACT [] -synonym: "regulation of interleukin-19 synthesis" EXACT [] -is_a: GO:0032662 ! regulation of interleukin-19 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042236 ! interleukin-19 biosynthetic process -relationship: regulates GO:0042236 ! interleukin-19 biosynthetic process - -[Term] -id: GO:0045385 -name: negative regulation of interleukin-19 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] -synonym: "down regulation of interleukin-19 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-19 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-19 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-19 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-19 biosynthesis" EXACT [] -synonym: "negative regulation of IL-19 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-19 anabolism" EXACT [] -synonym: "negative regulation of interleukin-19 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-19 formation" EXACT [] -synonym: "negative regulation of interleukin-19 synthesis" EXACT [] -is_a: GO:0032702 ! negative regulation of interleukin-19 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process -relationship: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process - -[Term] -id: GO:0045386 -name: positive regulation of interleukin-19 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] -synonym: "activation of interleukin-19 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-19 biosynthesis" EXACT [] -synonym: "positive regulation of IL-19 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-19 anabolism" EXACT [] -synonym: "positive regulation of interleukin-19 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-19 formation" EXACT [] -synonym: "positive regulation of interleukin-19 synthesis" EXACT [] -synonym: "stimulation of interleukin-19 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-19 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-19 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-19 biosynthetic process" EXACT [] -is_a: GO:0032742 ! positive regulation of interleukin-19 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process -relationship: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process - -[Term] -id: GO:0045387 -name: regulation of interleukin-20 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] -synonym: "regulation of IL-20 biosynthesis" EXACT [] -synonym: "regulation of IL-20 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-20 anabolism" EXACT [] -synonym: "regulation of interleukin-20 biosynthesis" EXACT [] -synonym: "regulation of interleukin-20 formation" EXACT [] -synonym: "regulation of interleukin-20 synthesis" EXACT [] -is_a: GO:0032664 ! regulation of interleukin-20 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042237 ! interleukin-20 biosynthetic process -relationship: regulates GO:0042237 ! interleukin-20 biosynthetic process - -[Term] -id: GO:0045388 -name: negative regulation of interleukin-20 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] -synonym: "down regulation of interleukin-20 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-20 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-20 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-20 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-20 biosynthesis" EXACT [] -synonym: "negative regulation of IL-20 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-20 anabolism" EXACT [] -synonym: "negative regulation of interleukin-20 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-20 formation" EXACT [] -synonym: "negative regulation of interleukin-20 synthesis" EXACT [] -is_a: GO:0032704 ! negative regulation of interleukin-20 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process -relationship: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process - -[Term] -id: GO:0045389 -name: positive regulation of interleukin-20 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] -synonym: "activation of interleukin-20 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-20 biosynthesis" EXACT [] -synonym: "positive regulation of IL-20 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-20 anabolism" EXACT [] -synonym: "positive regulation of interleukin-20 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-20 formation" EXACT [] -synonym: "positive regulation of interleukin-20 synthesis" EXACT [] -synonym: "stimulation of interleukin-20 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-20 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-20 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-20 biosynthetic process" EXACT [] -is_a: GO:0032744 ! positive regulation of interleukin-20 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process -relationship: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process - -[Term] -id: GO:0045390 -name: regulation of interleukin-21 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] -synonym: "regulation of IL-21 biosynthesis" EXACT [] -synonym: "regulation of IL-21 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-21 anabolism" EXACT [] -synonym: "regulation of interleukin-21 biosynthesis" EXACT [] -synonym: "regulation of interleukin-21 formation" EXACT [] -synonym: "regulation of interleukin-21 synthesis" EXACT [] -is_a: GO:0032665 ! regulation of interleukin-21 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042238 ! interleukin-21 biosynthetic process -relationship: regulates GO:0042238 ! interleukin-21 biosynthetic process - -[Term] -id: GO:0045391 -name: negative regulation of interleukin-21 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] -synonym: "down regulation of interleukin-21 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-21 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-21 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-21 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-21 biosynthesis" EXACT [] -synonym: "negative regulation of IL-21 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-21 anabolism" EXACT [] -synonym: "negative regulation of interleukin-21 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-21 formation" EXACT [] -synonym: "negative regulation of interleukin-21 synthesis" EXACT [] -is_a: GO:0032705 ! negative regulation of interleukin-21 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process -relationship: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process - -[Term] -id: GO:0045392 -name: positive regulation of interleukin-21 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] -synonym: "activation of interleukin-21 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-21 biosynthesis" EXACT [] -synonym: "positive regulation of IL-21 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-21 anabolism" EXACT [] -synonym: "positive regulation of interleukin-21 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-21 formation" EXACT [] -synonym: "positive regulation of interleukin-21 synthesis" EXACT [] -synonym: "stimulation of interleukin-21 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-21 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-21 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-21 biosynthetic process" EXACT [] -is_a: GO:0032745 ! positive regulation of interleukin-21 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process -relationship: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process - -[Term] -id: GO:0045393 -name: regulation of interleukin-22 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] -synonym: "regulation of IL-22 biosynthesis" EXACT [] -synonym: "regulation of IL-22 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-22 anabolism" EXACT [] -synonym: "regulation of interleukin-22 biosynthesis" EXACT [] -synonym: "regulation of interleukin-22 formation" EXACT [] -synonym: "regulation of interleukin-22 synthesis" EXACT [] -is_a: GO:0032666 ! regulation of interleukin-22 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042239 ! interleukin-22 biosynthetic process -relationship: regulates GO:0042239 ! interleukin-22 biosynthetic process - -[Term] -id: GO:0045394 -name: negative regulation of interleukin-22 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] -synonym: "down regulation of interleukin-22 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-22 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-22 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-22 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-22 biosynthesis" EXACT [] -synonym: "negative regulation of IL-22 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-22 anabolism" EXACT [] -synonym: "negative regulation of interleukin-22 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-22 formation" EXACT [] -synonym: "negative regulation of interleukin-22 synthesis" EXACT [] -is_a: GO:0032706 ! negative regulation of interleukin-22 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process -relationship: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process - -[Term] -id: GO:0045395 -name: positive regulation of interleukin-22 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] -synonym: "activation of interleukin-22 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-22 biosynthesis" EXACT [] -synonym: "positive regulation of IL-22 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-22 anabolism" EXACT [] -synonym: "positive regulation of interleukin-22 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-22 formation" EXACT [] -synonym: "positive regulation of interleukin-22 synthesis" EXACT [] -synonym: "stimulation of interleukin-22 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-22 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-22 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-22 biosynthetic process" EXACT [] -is_a: GO:0032746 ! positive regulation of interleukin-22 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process -relationship: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process - -[Term] -id: GO:0045396 -name: regulation of interleukin-23 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] -synonym: "regulation of IL-23 biosynthesis" EXACT [] -synonym: "regulation of IL-23 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-23 anabolism" EXACT [] -synonym: "regulation of interleukin-23 biosynthesis" EXACT [] -synonym: "regulation of interleukin-23 formation" EXACT [] -synonym: "regulation of interleukin-23 synthesis" EXACT [] -is_a: GO:0032667 ! regulation of interleukin-23 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042240 ! interleukin-23 biosynthetic process -relationship: regulates GO:0042240 ! interleukin-23 biosynthetic process - -[Term] -id: GO:0045397 -name: negative regulation of interleukin-23 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] -synonym: "down regulation of interleukin-23 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-23 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-23 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-23 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-23 biosynthesis" EXACT [] -synonym: "negative regulation of IL-23 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-23 anabolism" EXACT [] -synonym: "negative regulation of interleukin-23 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-23 formation" EXACT [] -synonym: "negative regulation of interleukin-23 synthesis" EXACT [] -is_a: GO:0032707 ! negative regulation of interleukin-23 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process -relationship: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process - -[Term] -id: GO:0045398 -name: positive regulation of interleukin-23 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] -synonym: "activation of interleukin-23 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-23 biosynthesis" EXACT [] -synonym: "positive regulation of IL-23 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-23 anabolism" EXACT [] -synonym: "positive regulation of interleukin-23 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-23 formation" EXACT [] -synonym: "positive regulation of interleukin-23 synthesis" EXACT [] -synonym: "stimulation of interleukin-23 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-23 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-23 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-23 biosynthetic process" EXACT [] -is_a: GO:0032747 ! positive regulation of interleukin-23 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process -relationship: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process - -[Term] -id: GO:0045399 -name: regulation of interleukin-3 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] -synonym: "regulation of IL-3 biosynthesis" EXACT [] -synonym: "regulation of IL-3 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-3 anabolism" EXACT [] -synonym: "regulation of interleukin-3 biosynthesis" EXACT [] -synonym: "regulation of interleukin-3 formation" EXACT [] -synonym: "regulation of interleukin-3 synthesis" EXACT [] -is_a: GO:0032672 ! regulation of interleukin-3 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042223 ! interleukin-3 biosynthetic process -relationship: regulates GO:0042223 ! interleukin-3 biosynthetic process - -[Term] -id: GO:0045400 -name: negative regulation of interleukin-3 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] -synonym: "down regulation of interleukin-3 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-3 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-3 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-3 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-3 biosynthesis" EXACT [] -synonym: "negative regulation of IL-3 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-3 anabolism" EXACT [] -synonym: "negative regulation of interleukin-3 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-3 formation" EXACT [] -synonym: "negative regulation of interleukin-3 synthesis" EXACT [] -is_a: GO:0032712 ! negative regulation of interleukin-3 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process -relationship: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process - -[Term] -id: GO:0045401 -name: positive regulation of interleukin-3 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] -synonym: "activation of interleukin-3 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-3 biosynthesis" EXACT [] -synonym: "positive regulation of IL-3 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-3 anabolism" EXACT [] -synonym: "positive regulation of interleukin-3 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-3 formation" EXACT [] -synonym: "positive regulation of interleukin-3 synthesis" EXACT [] -synonym: "stimulation of interleukin-3 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-3 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-3 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-3 biosynthetic process" EXACT [] -is_a: GO:0032752 ! positive regulation of interleukin-3 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process -relationship: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process - -[Term] -id: GO:0045402 -name: regulation of interleukin-4 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] -synonym: "regulation of IL-4 biosynthesis" EXACT [] -synonym: "regulation of IL-4 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-4 anabolism" EXACT [] -synonym: "regulation of interleukin-4 biosynthesis" EXACT [] -synonym: "regulation of interleukin-4 formation" EXACT [] -synonym: "regulation of interleukin-4 synthesis" EXACT [] -is_a: GO:0032673 ! regulation of interleukin-4 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042097 ! interleukin-4 biosynthetic process -relationship: regulates GO:0042097 ! interleukin-4 biosynthetic process - -[Term] -id: GO:0045403 -name: negative regulation of interleukin-4 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] -synonym: "down regulation of interleukin-4 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-4 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-4 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-4 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-4 biosynthesis" EXACT [] -synonym: "negative regulation of IL-4 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-4 anabolism" EXACT [] -synonym: "negative regulation of interleukin-4 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-4 formation" EXACT [] -synonym: "negative regulation of interleukin-4 synthesis" EXACT [] -is_a: GO:0032713 ! negative regulation of interleukin-4 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process -relationship: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process - -[Term] -id: GO:0045404 -name: positive regulation of interleukin-4 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] -synonym: "activation of interleukin-4 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-4 biosynthesis" EXACT [] -synonym: "positive regulation of IL-4 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-4 anabolism" EXACT [] -synonym: "positive regulation of interleukin-4 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-4 formation" EXACT [] -synonym: "positive regulation of interleukin-4 synthesis" EXACT [] -synonym: "stimulation of interleukin-4 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-4 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-4 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-4 biosynthetic process" EXACT [] -is_a: GO:0032753 ! positive regulation of interleukin-4 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process -relationship: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process - -[Term] -id: GO:0045405 -name: regulation of interleukin-5 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] -synonym: "regulation of IL-5 biosynthesis" EXACT [] -synonym: "regulation of IL-5 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-5 anabolism" EXACT [] -synonym: "regulation of interleukin-5 biosynthesis" EXACT [] -synonym: "regulation of interleukin-5 formation" EXACT [] -synonym: "regulation of interleukin-5 synthesis" EXACT [] -is_a: GO:0032674 ! regulation of interleukin-5 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042225 ! interleukin-5 biosynthetic process -relationship: regulates GO:0042225 ! interleukin-5 biosynthetic process - -[Term] -id: GO:0045406 -name: negative regulation of interleukin-5 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] -synonym: "down regulation of interleukin-5 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-5 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-5 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-5 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-5 biosynthesis" EXACT [] -synonym: "negative regulation of IL-5 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-5 anabolism" EXACT [] -synonym: "negative regulation of interleukin-5 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-5 formation" EXACT [] -synonym: "negative regulation of interleukin-5 synthesis" EXACT [] -is_a: GO:0032714 ! negative regulation of interleukin-5 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process -relationship: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process - -[Term] -id: GO:0045407 -name: positive regulation of interleukin-5 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] -synonym: "activation of interleukin-5 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-5 biosynthesis" EXACT [] -synonym: "positive regulation of IL-5 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-5 anabolism" EXACT [] -synonym: "positive regulation of interleukin-5 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-5 formation" EXACT [] -synonym: "positive regulation of interleukin-5 synthesis" EXACT [] -synonym: "stimulation of interleukin-5 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-5 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-5 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-5 biosynthetic process" EXACT [] -is_a: GO:0032754 ! positive regulation of interleukin-5 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process -relationship: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process - -[Term] -id: GO:0045408 -name: regulation of interleukin-6 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] -synonym: "regulation of IL-6 biosynthesis" EXACT [] -synonym: "regulation of IL-6 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-6 anabolism" EXACT [] -synonym: "regulation of interleukin-6 biosynthesis" EXACT [] -synonym: "regulation of interleukin-6 formation" EXACT [] -synonym: "regulation of interleukin-6 synthesis" EXACT [] -is_a: GO:0032675 ! regulation of interleukin-6 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042226 ! interleukin-6 biosynthetic process -relationship: regulates GO:0042226 ! interleukin-6 biosynthetic process - -[Term] -id: GO:0045409 -name: negative regulation of interleukin-6 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] -synonym: "down regulation of interleukin-6 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-6 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-6 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-6 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-6 biosynthesis" EXACT [] -synonym: "negative regulation of IL-6 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-6 anabolism" EXACT [] -synonym: "negative regulation of interleukin-6 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-6 formation" EXACT [] -synonym: "negative regulation of interleukin-6 synthesis" EXACT [] -is_a: GO:0032715 ! negative regulation of interleukin-6 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process -relationship: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process - -[Term] -id: GO:0045410 -name: positive regulation of interleukin-6 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] -synonym: "activation of interleukin-6 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-6 biosynthesis" EXACT [] -synonym: "positive regulation of IL-6 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-6 anabolism" EXACT [] -synonym: "positive regulation of interleukin-6 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-6 formation" EXACT [] -synonym: "positive regulation of interleukin-6 synthesis" EXACT [] -synonym: "stimulation of interleukin-6 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-6 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-6 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-6 biosynthetic process" EXACT [] -is_a: GO:0032755 ! positive regulation of interleukin-6 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process -relationship: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process - -[Term] -id: GO:0045411 -name: regulation of interleukin-7 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] -synonym: "regulation of IL-7 biosynthesis" EXACT [] -synonym: "regulation of IL-7 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-7 anabolism" EXACT [] -synonym: "regulation of interleukin-7 biosynthesis" EXACT [] -synonym: "regulation of interleukin-7 formation" EXACT [] -synonym: "regulation of interleukin-7 synthesis" EXACT [] -is_a: GO:0032676 ! regulation of interleukin-7 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042227 ! interleukin-7 biosynthetic process -relationship: regulates GO:0042227 ! interleukin-7 biosynthetic process - -[Term] -id: GO:0045412 -name: negative regulation of interleukin-7 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] -synonym: "down regulation of interleukin-7 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-7 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-7 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-7 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-7 biosynthesis" EXACT [] -synonym: "negative regulation of IL-7 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-7 anabolism" EXACT [] -synonym: "negative regulation of interleukin-7 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-7 formation" EXACT [] -synonym: "negative regulation of interleukin-7 synthesis" EXACT [] -is_a: GO:0032716 ! negative regulation of interleukin-7 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process -relationship: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process - -[Term] -id: GO:0045413 -name: positive regulation of interleukin-7 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] -synonym: "activation of interleukin-7 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-7 biosynthesis" EXACT [] -synonym: "positive regulation of IL-7 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-7 anabolism" EXACT [] -synonym: "positive regulation of interleukin-7 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-7 formation" EXACT [] -synonym: "positive regulation of interleukin-7 synthesis" EXACT [] -synonym: "stimulation of interleukin-7 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-7 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-7 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-7 biosynthetic process" EXACT [] -is_a: GO:0032756 ! positive regulation of interleukin-7 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process -relationship: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process - -[Term] -id: GO:0045414 -name: regulation of interleukin-8 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] -synonym: "regulation of IL-8 biosynthesis" EXACT [] -synonym: "regulation of IL-8 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-8 anabolism" EXACT [] -synonym: "regulation of interleukin-8 biosynthesis" EXACT [] -synonym: "regulation of interleukin-8 formation" EXACT [] -synonym: "regulation of interleukin-8 synthesis" EXACT [] -is_a: GO:0032677 ! regulation of interleukin-8 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042228 ! interleukin-8 biosynthetic process -relationship: regulates GO:0042228 ! interleukin-8 biosynthetic process - -[Term] -id: GO:0045415 -name: negative regulation of interleukin-8 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] -synonym: "down regulation of interleukin-8 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-8 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-8 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-8 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-8 biosynthesis" EXACT [] -synonym: "negative regulation of IL-8 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-8 anabolism" EXACT [] -synonym: "negative regulation of interleukin-8 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-8 formation" EXACT [] -synonym: "negative regulation of interleukin-8 synthesis" EXACT [] -is_a: GO:0032717 ! negative regulation of interleukin-8 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process -relationship: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process - -[Term] -id: GO:0045416 -name: positive regulation of interleukin-8 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] -synonym: "activation of interleukin-8 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-8 biosynthesis" EXACT [] -synonym: "positive regulation of IL-8 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-8 anabolism" EXACT [] -synonym: "positive regulation of interleukin-8 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-8 formation" EXACT [] -synonym: "positive regulation of interleukin-8 synthesis" EXACT [] -synonym: "stimulation of interleukin-8 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-8 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-8 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-8 biosynthetic process" EXACT [] -is_a: GO:0032757 ! positive regulation of interleukin-8 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process -relationship: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process - -[Term] -id: GO:0045417 -name: regulation of interleukin-9 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] -synonym: "regulation of IL-9 biosynthesis" EXACT [] -synonym: "regulation of IL-9 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-9 anabolism" EXACT [] -synonym: "regulation of interleukin-9 biosynthesis" EXACT [] -synonym: "regulation of interleukin-9 formation" EXACT [] -synonym: "regulation of interleukin-9 synthesis" EXACT [] -is_a: GO:0032678 ! regulation of interleukin-9 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0042229 ! interleukin-9 biosynthetic process -relationship: regulates GO:0042229 ! interleukin-9 biosynthetic process - -[Term] -id: GO:0045418 -name: negative regulation of interleukin-9 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] -synonym: "down regulation of interleukin-9 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-9 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-9 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-9 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-9 biosynthesis" EXACT [] -synonym: "negative regulation of IL-9 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-9 anabolism" EXACT [] -synonym: "negative regulation of interleukin-9 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-9 formation" EXACT [] -synonym: "negative regulation of interleukin-9 synthesis" EXACT [] -is_a: GO:0032718 ! negative regulation of interleukin-9 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process -relationship: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process - -[Term] -id: GO:0045419 -name: positive regulation of interleukin-9 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] -synonym: "activation of interleukin-9 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-9 biosynthesis" EXACT [] -synonym: "positive regulation of IL-9 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-9 anabolism" EXACT [] -synonym: "positive regulation of interleukin-9 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-9 formation" EXACT [] -synonym: "positive regulation of interleukin-9 synthesis" EXACT [] -synonym: "stimulation of interleukin-9 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-9 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-9 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-9 biosynthetic process" EXACT [] -is_a: GO:0032758 ! positive regulation of interleukin-9 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process -relationship: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process - -[Term] -id: GO:0045420 -name: regulation of connective tissue growth factor biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] -synonym: "regulation of connective tissue growth factor anabolism" EXACT [] -synonym: "regulation of connective tissue growth factor biosynthesis" EXACT [] -synonym: "regulation of connective tissue growth factor formation" EXACT [] -synonym: "regulation of connective tissue growth factor synthesis" EXACT [] -is_a: GO:0032643 ! regulation of connective tissue growth factor production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0045189 ! connective tissue growth factor biosynthetic process -relationship: regulates GO:0045189 ! connective tissue growth factor biosynthetic process - -[Term] -id: GO:0045421 -name: negative regulation of connective tissue growth factor biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] -synonym: "down regulation of connective tissue growth factor biosynthetic process" EXACT [] -synonym: "down-regulation of connective tissue growth factor biosynthetic process" EXACT [] -synonym: "downregulation of connective tissue growth factor biosynthetic process" EXACT [] -synonym: "inhibition of connective tissue growth factor biosynthetic process" NARROW [] -synonym: "negative regulation of connective tissue growth factor anabolism" EXACT [] -synonym: "negative regulation of connective tissue growth factor biosynthesis" EXACT [] -synonym: "negative regulation of connective tissue growth factor formation" EXACT [] -synonym: "negative regulation of connective tissue growth factor synthesis" EXACT [] -is_a: GO:0032683 ! negative regulation of connective tissue growth factor production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process -relationship: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process - -[Term] -id: GO:0045422 -name: positive regulation of connective tissue growth factor biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] -synonym: "activation of connective tissue growth factor biosynthetic process" NARROW [] -synonym: "positive regulation of connective tissue growth factor anabolism" EXACT [] -synonym: "positive regulation of connective tissue growth factor biosynthesis" EXACT [] -synonym: "positive regulation of connective tissue growth factor formation" EXACT [] -synonym: "positive regulation of connective tissue growth factor synthesis" EXACT [] -synonym: "stimulation of connective tissue growth factor biosynthetic process" NARROW [] -synonym: "up regulation of connective tissue growth factor biosynthetic process" EXACT [] -synonym: "up-regulation of connective tissue growth factor biosynthetic process" EXACT [] -synonym: "upregulation of connective tissue growth factor biosynthetic process" EXACT [] -is_a: GO:0032723 ! positive regulation of connective tissue growth factor production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process -relationship: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process - [Term] id: GO:0045423 name: regulation of granulocyte macrophage colony-stimulating factor biosynthetic process @@ -270232,7 +268644,6 @@ synonym: "regulation of nitric oxide anabolism" EXACT [] synonym: "regulation of nitric oxide biosynthesis" EXACT [] synonym: "regulation of nitric oxide formation" EXACT [] synonym: "regulation of nitric oxide synthesis" EXACT [] -is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process @@ -270327,6 +268738,7 @@ def: "Catalysis of the cyclization of beta rings at one or both ends of the lyco synonym: "crtL" RELATED [] synonym: "lycopene cyclase" BROAD [] xref: MetaCyc:RXN1F-150 +xref: RHEA:32219 is_a: GO:0009975 ! cyclase activity is_a: GO:0016860 ! intramolecular oxidoreductase activity @@ -270530,7 +268942,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [PMID:10618248] synonym: "sterigmatocystin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0043385 ! mycotoxin metabolic process +is_a: GO:0009404 ! toxin metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process [Term] @@ -270542,8 +268954,8 @@ synonym: "sterigmatocystin anabolism" EXACT [] synonym: "sterigmatocystin biosynthesis" EXACT [] synonym: "sterigmatocystin formation" EXACT [] synonym: "sterigmatocystin synthesis" EXACT [] +is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process -is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0045460 ! sterigmatocystin metabolic process is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process @@ -270629,9 +269041,6 @@ name: response to ethanol namespace: biological_process alt_id: GO:0017036 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] -is_a: GO:0009636 ! response to toxic substance -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol [Term] @@ -270819,6 +269228,7 @@ synonym: "naringenin 3-hydroxylase activity" EXACT [EC:1.14.11.9] synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.9] xref: EC:1.14.11.9 xref: MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN +xref: RHEA:18621 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] @@ -270833,7 +269243,6 @@ synonym: "gibberellic acid degradation" NARROW [] synonym: "gibberellin catabolism" EXACT [] is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0016103 ! diterpenoid catabolic process -is_a: GO:0042447 ! hormone catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] @@ -270843,7 +269252,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge." [GOC:tair_curators] synonym: "pectin metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process -is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0045489 @@ -270866,7 +269274,6 @@ synonym: "pectin breakdown" EXACT [] synonym: "pectin catabolism" EXACT [] synonym: "pectin degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0045488 ! pectin metabolic process [Term] @@ -271158,312 +269565,6 @@ synonym: "IL-27" NARROW [] synonym: "interleukin-27 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding -[Term] -id: GO:0045524 -name: interleukin-24 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] -synonym: "IL-24 biosynthesis" EXACT [] -synonym: "IL-24 biosynthetic process" EXACT [] -synonym: "interleukin-24 anabolism" EXACT [] -synonym: "interleukin-24 biosynthesis" EXACT [] -synonym: "interleukin-24 formation" EXACT [] -synonym: "interleukin-24 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032628 ! interleukin-24 production - -[Term] -id: GO:0045525 -name: interleukin-25 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] -synonym: "IL-25 biosynthesis" EXACT [] -synonym: "IL-25 biosynthetic process" EXACT [] -synonym: "interleukin-25 anabolism" EXACT [] -synonym: "interleukin-25 biosynthesis" EXACT [] -synonym: "interleukin-25 formation" EXACT [] -synonym: "interleukin-25 synthesis" EXACT [] -is_a: GO:0042235 ! interleukin-17 biosynthetic process -relationship: part_of GO:0032629 ! interleukin-25 production - -[Term] -id: GO:0045526 -name: interleukin-26 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] -synonym: "IL-26 biosynthesis" EXACT [] -synonym: "IL-26 biosynthetic process" EXACT [] -synonym: "interleukin-26 anabolism" EXACT [] -synonym: "interleukin-26 biosynthesis" EXACT [] -synonym: "interleukin-26 formation" EXACT [] -synonym: "interleukin-26 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032630 ! interleukin-26 production - -[Term] -id: GO:0045527 -name: interleukin-27 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] -synonym: "IL-27 biosynthesis" EXACT [] -synonym: "IL-27 biosynthetic process" EXACT [] -synonym: "interleukin-27 anabolism" EXACT [] -synonym: "interleukin-27 biosynthesis" EXACT [] -synonym: "interleukin-27 formation" EXACT [] -synonym: "interleukin-27 synthesis" EXACT [] -is_a: GO:0042089 ! cytokine biosynthetic process -relationship: part_of GO:0032631 ! interleukin-27 production - -[Term] -id: GO:0045528 -name: regulation of interleukin-24 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] -synonym: "regulation of IL-24 biosynthesis" EXACT [] -synonym: "regulation of IL-24 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-24 anabolism" EXACT [] -synonym: "regulation of interleukin-24 biosynthesis" EXACT [] -synonym: "regulation of interleukin-24 formation" EXACT [] -synonym: "regulation of interleukin-24 synthesis" EXACT [] -is_a: GO:0032668 ! regulation of interleukin-24 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0045524 ! interleukin-24 biosynthetic process -relationship: regulates GO:0045524 ! interleukin-24 biosynthetic process - -[Term] -id: GO:0045529 -name: regulation of interleukin-25 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] -synonym: "regulation of IL-25 biosynthesis" EXACT [] -synonym: "regulation of IL-25 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-25 anabolism" EXACT [] -synonym: "regulation of interleukin-25 biosynthesis" EXACT [] -synonym: "regulation of interleukin-25 formation" EXACT [] -synonym: "regulation of interleukin-25 synthesis" EXACT [] -is_a: GO:0032669 ! regulation of interleukin-25 production -is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0045525 ! interleukin-25 biosynthetic process -relationship: regulates GO:0045525 ! interleukin-25 biosynthetic process - -[Term] -id: GO:0045530 -name: regulation of interleukin-26 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] -synonym: "regulation of IL-26 biosynthesis" EXACT [] -synonym: "regulation of IL-26 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-26 anabolism" EXACT [] -synonym: "regulation of interleukin-26 biosynthesis" EXACT [] -synonym: "regulation of interleukin-26 formation" EXACT [] -synonym: "regulation of interleukin-26 synthesis" EXACT [] -is_a: GO:0032670 ! regulation of interleukin-26 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0045526 ! interleukin-26 biosynthetic process -relationship: regulates GO:0045526 ! interleukin-26 biosynthetic process - -[Term] -id: GO:0045531 -name: regulation of interleukin-27 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] -synonym: "regulation of IL-27 biosynthesis" EXACT [] -synonym: "regulation of IL-27 biosynthetic process" EXACT [] -synonym: "regulation of interleukin-27 anabolism" EXACT [] -synonym: "regulation of interleukin-27 biosynthesis" EXACT [] -synonym: "regulation of interleukin-27 formation" EXACT [] -synonym: "regulation of interleukin-27 synthesis" EXACT [] -is_a: GO:0032671 ! regulation of interleukin-27 production -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0045527 ! interleukin-27 biosynthetic process -relationship: regulates GO:0045527 ! interleukin-27 biosynthetic process - -[Term] -id: GO:0045532 -name: negative regulation of interleukin-24 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] -synonym: "down regulation of interleukin-24 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-24 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-24 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-24 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-24 biosynthesis" EXACT [] -synonym: "negative regulation of IL-24 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-24 anabolism" EXACT [] -synonym: "negative regulation of interleukin-24 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-24 formation" EXACT [] -synonym: "negative regulation of interleukin-24 synthesis" EXACT [] -is_a: GO:0032708 ! negative regulation of interleukin-24 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process -relationship: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process - -[Term] -id: GO:0045533 -name: negative regulation of interleukin-25 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] -synonym: "down regulation of interleukin-25 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-25 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-25 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-25 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-25 biosynthesis" EXACT [] -synonym: "negative regulation of IL-25 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-25 anabolism" EXACT [] -synonym: "negative regulation of interleukin-25 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-25 formation" EXACT [] -synonym: "negative regulation of interleukin-25 synthesis" EXACT [] -is_a: GO:0032709 ! negative regulation of interleukin-25 production -is_a: GO:0045379 ! negative regulation of interleukin-17 biosynthetic process -is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process -relationship: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process - -[Term] -id: GO:0045534 -name: negative regulation of interleukin-26 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] -synonym: "down regulation of interleukin-26 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-26 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-26 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-26 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-26 biosynthesis" EXACT [] -synonym: "negative regulation of IL-26 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-26 anabolism" EXACT [] -synonym: "negative regulation of interleukin-26 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-26 formation" EXACT [] -synonym: "negative regulation of interleukin-26 synthesis" EXACT [] -is_a: GO:0032710 ! negative regulation of interleukin-26 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process -relationship: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process - -[Term] -id: GO:0045535 -name: negative regulation of interleukin-27 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] -synonym: "down regulation of interleukin-27 biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-27 biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-27 biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-27 biosynthetic process" NARROW [] -synonym: "negative regulation of IL-27 biosynthesis" EXACT [] -synonym: "negative regulation of IL-27 biosynthetic process" EXACT [] -synonym: "negative regulation of interleukin-27 anabolism" EXACT [] -synonym: "negative regulation of interleukin-27 biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-27 formation" EXACT [] -synonym: "negative regulation of interleukin-27 synthesis" EXACT [] -is_a: GO:0032711 ! negative regulation of interleukin-27 production -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process -relationship: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process - -[Term] -id: GO:0045536 -name: positive regulation of interleukin-24 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] -synonym: "activation of interleukin-24 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-24 biosynthesis" EXACT [] -synonym: "positive regulation of IL-24 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-24 anabolism" EXACT [] -synonym: "positive regulation of interleukin-24 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-24 formation" EXACT [] -synonym: "positive regulation of interleukin-24 synthesis" EXACT [] -synonym: "stimulation of interleukin-24 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-24 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-24 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-24 biosynthetic process" EXACT [] -is_a: GO:0032748 ! positive regulation of interleukin-24 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process -relationship: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process - -[Term] -id: GO:0045537 -name: positive regulation of interleukin-25 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] -synonym: "activation of interleukin-25 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-25 biosynthesis" EXACT [] -synonym: "positive regulation of IL-25 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-25 anabolism" EXACT [] -synonym: "positive regulation of interleukin-25 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-25 formation" EXACT [] -synonym: "positive regulation of interleukin-25 synthesis" EXACT [] -synonym: "stimulation of interleukin-25 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-25 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-25 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-25 biosynthetic process" EXACT [] -is_a: GO:0032749 ! positive regulation of interleukin-25 production -is_a: GO:0045380 ! positive regulation of interleukin-17 biosynthetic process -is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process -relationship: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process - -[Term] -id: GO:0045538 -name: positive regulation of interleukin-26 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] -synonym: "activation of interleukin-26 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-26 biosynthesis" EXACT [] -synonym: "positive regulation of IL-26 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-26 anabolism" EXACT [] -synonym: "positive regulation of interleukin-26 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-26 formation" EXACT [] -synonym: "positive regulation of interleukin-26 synthesis" EXACT [] -synonym: "stimulation of interleukin-26 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-26 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-26 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-26 biosynthetic process" EXACT [] -is_a: GO:0032750 ! positive regulation of interleukin-26 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process -relationship: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process - -[Term] -id: GO:0045539 -name: positive regulation of interleukin-27 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] -synonym: "activation of interleukin-27 biosynthetic process" NARROW [] -synonym: "positive regulation of IL-27 biosynthesis" EXACT [] -synonym: "positive regulation of IL-27 biosynthetic process" EXACT [] -synonym: "positive regulation of interleukin-27 anabolism" EXACT [] -synonym: "positive regulation of interleukin-27 biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-27 formation" EXACT [] -synonym: "positive regulation of interleukin-27 synthesis" EXACT [] -synonym: "stimulation of interleukin-27 biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-27 biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-27 biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-27 biosynthetic process" EXACT [] -is_a: GO:0032751 ! positive regulation of interleukin-27 production -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process -relationship: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process - [Term] id: GO:0045540 name: regulation of cholesterol biosynthetic process @@ -271957,8 +270058,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of sterigma synonym: "sterigmatocystin breakdown" EXACT [] synonym: "sterigmatocystin catabolism" EXACT [] synonym: "sterigmatocystin degradation" EXACT [] +is_a: GO:0009407 ! toxin catabolic process is_a: GO:0019439 ! aromatic compound catabolic process -is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0045460 ! sterigmatocystin metabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process @@ -274412,7 +272513,6 @@ synonym: "acetate catabolism" EXACT [] synonym: "acetate degradation" EXACT [] synonym: "homoacetate catabolic process" RELATED [] is_a: GO:0006083 ! acetate metabolic process -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] @@ -278836,6 +276936,7 @@ synonym: "PDAT activity" EXACT [EC:2.3.1.158] synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.158] xref: EC:2.3.1.158 xref: MetaCyc:2.3.1.158-RXN +xref: RHEA:14057 is_a: GO:0008080 ! N-acetyltransferase activity [Term] @@ -278901,7 +277002,6 @@ synonym: "adenylate forming enzyme activity" RELATED [] synonym: "AMP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process -is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0046034 @@ -279446,7 +277546,6 @@ name: adenosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] synonym: "adenosine metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] @@ -280045,7 +278144,6 @@ synonym: "coenzyme and prosthetic group biosynthetic process" EXACT [] synonym: "coenzyme and prosthetic group formation" EXACT [] synonym: "coenzyme and prosthetic group synthesis" EXACT [] is_obsolete: true -consider: GO:0009108 consider: GO:0051191 [Term] @@ -280059,7 +278157,6 @@ synonym: "coenzyme and prosthetic group catabolic process" EXACT [] synonym: "coenzyme and prosthetic group catabolism" EXACT [] synonym: "coenzyme and prosthetic group degradation" EXACT [] is_obsolete: true -consider: GO:0009109 consider: GO:0051190 [Term] @@ -280073,7 +278170,6 @@ synonym: "corrin formation" EXACT [] synonym: "corrin synthesis" EXACT [] is_a: GO:0015009 ! corrin metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0046141 @@ -280085,7 +278181,6 @@ synonym: "corrin catabolism" EXACT [] synonym: "corrin degradation" EXACT [] is_a: GO:0015009 ! corrin metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process -is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0046142 @@ -280095,7 +278190,6 @@ def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate comment: This term was made obsolete because it was replaced by more specific terms. synonym: "negative regulation of coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true -consider: GO:0051198 consider: GO:0051201 [Term] @@ -280106,7 +278200,6 @@ def: "OBSOLETE. Any process that activates or increases the frequency, rate or e comment: This term was made obsolete because it was replaced by more specific terms. synonym: "positive regulation of coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true -consider: GO:0051197 consider: GO:0051200 [Term] @@ -280136,8 +278229,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [PMID:21871890] synonym: "5,6,7,8-tetrahydrobiopterin metabolic process" EXACT [GOC:curators] synonym: "tetrahydrobiopterin metabolism" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0034311 ! diol metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process @@ -280150,10 +278241,8 @@ synonym: "5,6,7,8-tetrahydrobiopterin catabolic process" EXACT [Wikipedia:Tetrah synonym: "tetrahydrobiopterin breakdown" EXACT [] synonym: "tetrahydrobiopterin catabolism" EXACT [] synonym: "tetrahydrobiopterin degradation" EXACT [] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0034313 ! diol catabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046146 ! tetrahydrobiopterin metabolic process [Term] @@ -280778,7 +278867,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of cresol, synonym: "cresol breakdown" EXACT [] synonym: "cresol catabolism" EXACT [] synonym: "cresol degradation" EXACT [] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042212 ! cresol metabolic process @@ -280883,7 +278971,6 @@ synonym: "spermine catabolism" EXACT [] synonym: "spermine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0008215 ! spermine metabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0046209 @@ -280891,8 +278978,6 @@ name: nitric oxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] synonym: "nitric oxide metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process -is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0072593 ! reactive oxygen species metabolic process is_a: GO:2001057 ! reactive nitrogen species metabolic process @@ -280904,8 +278989,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of nitric o synonym: "nitric oxide breakdown" EXACT [] synonym: "nitric oxide catabolism" EXACT [] synonym: "nitric oxide degradation" EXACT [] -is_a: GO:0042135 ! neurotransmitter catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046209 ! nitric oxide metabolic process @@ -280958,8 +279041,9 @@ synonym: "enterobactin catabolism" EXACT [] synonym: "enterobactin degradation" EXACT [] is_a: GO:0009238 ! enterobactin metabolic process is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0046215 ! siderophore catabolic process -is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901335 ! lactone catabolic process [Term] id: GO:0046215 @@ -280971,7 +279055,6 @@ synonym: "siderophore breakdown" EXACT [] synonym: "siderophore catabolism" EXACT [] synonym: "siderophore degradation" EXACT [] is_a: GO:0009237 ! siderophore metabolic process -is_a: GO:0051187 ! cofactor catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process [Term] @@ -281132,10 +279215,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of 2,4,5-tr synonym: "2,4,5-trichlorophenoxyacetic acid breakdown" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid catabolism" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid degradation" EXACT [] -is_a: GO:0009852 ! auxin catabolic process is_a: GO:0018980 ! 2,4,5-trichlorophenoxyacetic acid metabolic process is_a: GO:0019439 ! aromatic compound catabolic process -is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process @@ -281256,7 +279337,6 @@ synonym: "mandelate anabolism" EXACT [] synonym: "mandelate biosynthesis" EXACT [] synonym: "mandelate formation" EXACT [] synonym: "mandelate synthesis" EXACT [] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018924 ! mandelate metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process @@ -281376,10 +279456,7 @@ synonym: "salicylic acid breakdown" EXACT [] synonym: "salicylic acid catabolism" EXACT [] synonym: "salicylic acid degradation" EXACT [] is_a: GO:0009696 ! salicylic acid metabolic process -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process -is_a: GO:0042447 ! hormone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] @@ -281817,7 +279894,6 @@ def: "The chemical reactions and pathways involving protocatechuate, the anion o synonym: "protocatechuate metabolic process" EXACT [PMID:25072253] synonym: "protocatechuate metabolism" EXACT [] is_a: GO:0009712 ! catechol-containing compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process @@ -281905,7 +279981,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732] synonym: "flavonoid phytoalexin metabolism" EXACT [] is_a: GO:0009812 ! flavonoid metabolic process -is_a: GO:0052314 ! phytoalexin metabolic process [Term] id: GO:0046286 @@ -281988,7 +280063,6 @@ synonym: "formaldehyde metabolism" EXACT [] synonym: "methanal metabolic process" EXACT [] synonym: "methanal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] @@ -282002,7 +280076,6 @@ synonym: "formaldehyde formation" EXACT [] synonym: "formaldehyde synthesis" EXACT [] synonym: "methanal biosynthesis" EXACT [] synonym: "methanal biosynthetic process" EXACT [] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0046292 ! formaldehyde metabolic process @@ -282017,7 +280090,6 @@ synonym: "formaldehyde catabolism" EXACT [] synonym: "formaldehyde degradation" EXACT [] synonym: "methanal catabolic process" EXACT [] synonym: "methanal catabolism" EXACT [] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046292 ! formaldehyde metabolic process @@ -282046,7 +280118,6 @@ synonym: "glycolate catabolism" EXACT [] synonym: "glycolate degradation" EXACT [] is_a: GO:0009441 ! glycolate metabolic process is_a: GO:0034310 ! primary alcohol catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] @@ -282098,10 +280169,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dich synonym: "2,4-dichlorophenoxyacetic acid breakdown" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid catabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid degradation" EXACT [] -is_a: GO:0009852 ! auxin catabolic process is_a: GO:0018901 ! 2,4-dichlorophenoxyacetic acid metabolic process is_a: GO:0019439 ! aromatic compound catabolic process -is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process @@ -282130,7 +280199,6 @@ synonym: "2-chloro-N-isopropylacetanilide catabolism" EXACT [] synonym: "2-chloro-N-isopropylacetanilide degradation" EXACT [] is_a: GO:0018889 ! 2-chloro-N-isopropylacetanilide metabolic process is_a: GO:0019439 ! aromatic compound catabolic process -is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process @@ -282628,7 +280696,6 @@ name: CDP-diacylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis." [PMID:24533860] synonym: "CDP-diacylglycerol metabolism" EXACT [] -is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] @@ -282639,7 +280706,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of CDP-diac synonym: "CDP-diacylglycerol breakdown" EXACT [] synonym: "CDP-diacylglycerol catabolism" EXACT [] synonym: "CDP-diacylglycerol degradation" EXACT [] -is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0046341 ! CDP-diacylglycerol metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process @@ -282818,7 +280884,6 @@ synonym: "acetyl-CoA breakdown" EXACT [] synonym: "acetyl-CoA catabolism" EXACT [] synonym: "acetyl-CoA degradation" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process @@ -283093,9 +281158,10 @@ synonym: "N-acetylneuraminate biosynthesis" EXACT [] synonym: "N-acetylneuraminate formation" EXACT [] synonym: "N-acetylneuraminate synthesis" EXACT [] is_a: GO:0006054 ! N-acetylneuraminate metabolic process -is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0046349 ! amino sugar biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0046381 @@ -283325,6 +281391,7 @@ synonym: "polynucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.32] xref: EC:3.1.3.32 xref: MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN xref: Reactome:R-HSA-5649705 "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)" +xref: RHEA:14113 is_a: GO:0098518 ! polynucleotide phosphatase activity relationship: part_of GO:0098506 ! polynucleotide 3' dephosphorylation @@ -283340,6 +281407,7 @@ synonym: "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity xref: EC:2.7.1.78 xref: KEGG_REACTION:R03840 xref: MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN +xref: RHEA:15669 is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity @@ -283606,6 +281674,7 @@ def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophos synonym: "1,4-Dihydroxy-2-naphtoate prenyltransferase activity" EXACT [] xref: EC:2.5.1 xref: MetaCyc:DMK-RXN +xref: RHEA:30099 is_a: GO:0002094 ! polyprenyltransferase activity [Term] @@ -283620,6 +281689,7 @@ synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" EXACT [M xref: EC:1.17.7.1 xref: KEGG_REACTION:R08689 xref: MetaCyc:RXN0-882 +xref: RHEA:26119 is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor [Term] @@ -283645,7 +281715,6 @@ name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process [Term] @@ -283728,7 +281797,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-lysine metabolism" EXACT [] is_a: GO:0006553 ! lysine metabolic process -is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0046441 @@ -283746,7 +281814,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] synonym: "aerobactin metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process -is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] @@ -283767,7 +281834,6 @@ name: FMN metabolic process namespace: biological_process def: "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, PMID:20822113] synonym: "FMN metabolism" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process @@ -284040,7 +282106,7 @@ synonym: "PAF metabolic process" EXACT [] synonym: "PAF metabolism" EXACT [] synonym: "platelet activating factor metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process -is_a: GO:0017144 ! drug metabolic process +is_a: GO:0046485 ! ether lipid metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] @@ -284344,7 +282410,6 @@ synonym: "S-adenosylhomocysteine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process -is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] @@ -284365,9 +282430,7 @@ synonym: "S-adenosyl methionine metabolic process" EXACT [] synonym: "S-adenosyl methionine metabolism" EXACT [] synonym: "S-adenosylmethionine metabolism" EXACT [] synonym: "SAM metabolic process" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] @@ -284492,6 +282555,7 @@ def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfo synonym: "sulfolipid synthase" BROAD [] synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT [] xref: MetaCyc:RXN-1224 +xref: RHEA:49468 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -284689,6 +282753,7 @@ xref: EC:2.4.1.133 xref: MetaCyc:2.4.1.133-RXN xref: Reactome:R-HSA-1889981 "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker" xref: Reactome:R-HSA-3560804 "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker" +xref: RHEA:15297 is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein @@ -285082,6 +283147,7 @@ synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" EXACT [EC:3.2.1.1 synonym: "alpha-glucosiduronase activity" EXACT [EC:3.2.1.139] xref: EC:3.2.1.139 xref: MetaCyc:3.2.1.139-RXN +xref: RHEA:20005 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -285096,8 +283162,6 @@ synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32] synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32] synonym: "scytalidopepsin B activity" EXACT [] synonym: "SLB" RELATED [EC:3.4.23.32] -xref: EC:3.4.23.32 -xref: MetaCyc:3.4.23.32-RXN is_obsolete: true replaced_by: GO:0004190 @@ -285122,8 +283186,6 @@ synonym: "Penicillium janthinellum aspartic proteinase activity" EXACT [EC:3.4.2 synonym: "Penicillium roqueforti acid proteinase activity" EXACT [EC:3.4.23.20] synonym: "penicillopepsin activity" EXACT [] synonym: "peptidase A activity" BROAD [EC:3.4.23.20] -xref: EC:3.4.23.20 -xref: MetaCyc:3.4.23.20-RXN is_obsolete: true replaced_by: GO:0004190 @@ -285303,6 +283365,7 @@ synonym: "long-chain fatty alcohol oxidase activity" EXACT [] synonym: "long-chain-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20] xref: EC:1.1.3.20 xref: MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN +xref: RHEA:22756 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] @@ -285369,7 +283432,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732] synonym: "enniatin metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process -is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:0050761 ! depsipeptide metabolic process is_a: GO:1901334 ! lactone metabolic process @@ -285383,7 +283445,6 @@ synonym: "enniatin biosynthesis" EXACT [] synonym: "enniatin formation" EXACT [] synonym: "enniatin synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process -is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0046584 ! enniatin metabolic process is_a: GO:0050763 ! depsipeptide biosynthetic process is_a: GO:1901336 ! lactone biosynthetic process @@ -286278,7 +284339,6 @@ synonym: "vitamin M metabolic process" EXACT [] synonym: "vitamin M metabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] @@ -286319,7 +284379,6 @@ synonym: "vitamin M catabolic process" EXACT [] synonym: "vitamin M catabolism" EXACT [] is_a: GO:0009397 ! folic acid-containing compound catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0046655 ! folic acid metabolic process @@ -286556,8 +284615,7 @@ name: response to streptomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:curators] synonym: "streptomycin susceptibility/resistance" RELATED [] -is_a: GO:0042493 ! response to drug -is_a: GO:0060992 ! response to fungicide +is_a: GO:0046677 ! response to antibiotic is_a: GO:1903416 ! response to glycoside [Term] @@ -286569,7 +284627,6 @@ synonym: "DDT resistance" RELATED [] synonym: "DDT susceptibility/resistance" RELATED [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0017085 ! response to insecticide -is_a: GO:0042493 ! response to drug [Term] id: GO:0046681 @@ -286891,7 +284948,6 @@ namespace: biological_process def: "The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [PMID:21710975] synonym: "boron transport" RELATED [] is_a: GO:0015698 ! inorganic anion transport -is_a: GO:0015893 ! drug transport [Term] id: GO:0046714 @@ -286899,7 +284955,6 @@ name: borate binding namespace: molecular_function def: "Interacting selectively and non-covalently with borate, the anion (BO3)3-." [GOC:curators] synonym: "boron binding" RELATED [] -is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding [Term] @@ -288379,7 +286434,6 @@ name: quinolinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] synonym: "quinolinate metabolism" EXACT [] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process @@ -288694,8 +286748,6 @@ def: "Any process that results in a change in state or activity of a cell or an synonym: "response to actidione" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug -is_a: GO:0060992 ! response to fungicide is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone @@ -289053,28 +287105,35 @@ is_a: GO:0065003 ! protein-containing complex assembly id: GO:0046932 name: sodium-transporting ATP synthase activity, rotational mechanism namespace: molecular_function -def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism." [EC:7.2.2.1, RHEA:58158, TC:3.A.2.1.2] +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism." [RHEA:58158] synonym: "sodium-translocating F-type ATPase activity" EXACT [] synonym: "sodium-transporting two-sector ATPase activity" EXACT [] xref: EC:7.2.2.1 xref: MetaCyc:3.6.3.15-RXN xref: RHEA:58158 +xref: TC:3.A.2.1.2 is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0016874 ! ligase activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19380 xsd:anyURI [Term] id: GO:0046933 name: proton-transporting ATP synthase activity, rotational mechanism namespace: molecular_function -def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:7.1.2.2, TC:3.A.2.1.1] +def: "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out)." [RHEA:57722] synonym: "H+-transporting ATP synthase activity" EXACT [EC:7.1.2.2] synonym: "hydrogen ion translocating F-type ATPase activity" EXACT [] synonym: "hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [] synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT [] +xref: EC:7.1.2.2 xref: MetaCyc:ATPSYN-RXN xref: Reactome:R-HSA-164832 "ATPase synthesizes ATP" xref: RHEA:57722 +xref: TC:3.A.2.1.1 is_a: GO:0015252 ! proton channel activity -is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0016874 ! ligase activity +relationship: part_of GO:0015986 ! ATP synthesis coupled proton transport +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19380 xsd:anyURI [Term] id: GO:0046934 @@ -289128,6 +287187,11 @@ xref: Reactome:R-HSA-8852019 "MET bound PI3K generates PIP3" xref: Reactome:R-HSA-8853323 "Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-9021627 "EPOR-associated PI3K phosphorylates PIP2 to PIP3" xref: Reactome:R-HSA-9603445 "Activated NTRK3 stimulates PI3K activity" +xref: Reactome:R-HSA-9664664 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3" +xref: Reactome:R-HSA-9664940 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3" +xref: Reactome:R-HSA-9665407 "PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3" +xref: Reactome:R-HSA-9672162 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers" +xref: Reactome:R-HSA-9672177 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR" xref: RHEA:21292 is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity is_a: GO:0052813 ! phosphatidylinositol bisphosphate kinase activity @@ -289150,6 +287214,7 @@ namespace: molecular_function def: "Catalysis of the reaction: deoxyadenosine + H2O = deoxyinosine + NH3." [EC:3.5.4.4, GOC:ai] synonym: "deoxyadenosine deaminase reaction" EXACT [] xref: MetaCyc:ADDALT-RXN +xref: RHEA:28190 is_a: GO:0019239 ! deaminase activity [Term] @@ -289322,7 +287387,7 @@ synonym: "ketone body degradation" EXACT [] synonym: "utilization of ketone bodies" EXACT [Reactome:R-HSA-77108] xref: MetaCyc:PWY66-368 xref: Reactome:R-HSA-77108 -is_a: GO:0042737 ! drug catabolic process +is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046950 ! cellular ketone body metabolic process is_a: GO:1901569 ! fatty acid derivative catabolic process @@ -289380,28 +287445,25 @@ is_a: GO:0046958 ! nonassociative learning id: GO:0046961 name: proton-transporting ATPase activity, rotational mechanism namespace: molecular_function -def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14] -synonym: "ATP phosphohydrolase (H+-transporting) activity" EXACT [EC:3.6.3.14] -synonym: "ATP synthase activity" BROAD [EC:3.6.3.14] -synonym: "bacterial Ca2+/Mg2+ ATPase" NARROW [EC:3.6.3.14] -synonym: "chloroplast ATPase activity" NARROW [EC:3.6.3.14] -synonym: "coupling factors (Fo, F1 and CF1)" RELATED [EC:3.6.3.14] -synonym: "F(0)F(1)-ATPase activity" NARROW [EC:3.6.3.14] -synonym: "F(1)-ATPase activity" NARROW [EC:3.6.3.14] -synonym: "F(o)F(1)-ATPase activity" NARROW [EC:3.6.3.14] -synonym: "F0F1-ATPase" NARROW [EC:3.6.3.14] -synonym: "F1-ATPase" NARROW [EC:3.6.3.14] -synonym: "FoF1-ATPase" NARROW [EC:3.6.3.14] -synonym: "H(+)-transporting ATP synthase activity" EXACT [EC:3.6.3.14] -synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.14] -synonym: "H+-transporting ATPase activity" EXACT [EC:3.6.3.14] -synonym: "H+-transporting two-sector ATPase" NARROW [EC:3.6.3.14] +def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721] +synonym: "ATP phosphohydrolase (H+-transporting) activity" RELATED [] +synonym: "ATP synthase activity" BROAD [EC:7.1.2.2] +synonym: "chloroplast ATPase activity" NARROW [EC:7.1.2.2] +synonym: "F(0)F(1)-ATPase activity" NARROW [EC:7.1.2.2] +synonym: "F(1)-ATPase activity" NARROW [EC:7.1.2.2] +synonym: "F(o)F(1)-ATPase activity" NARROW [EC:7.1.2.2] +synonym: "F0F1-ATPase" NARROW [EC:7.1.2.2] +synonym: "F1-ATPase" NARROW [] +synonym: "FoF1-ATPase" NARROW [EC:7.1.2.2] +synonym: "H(+)-transporting ATP synthase activity" RELATED [EC:7.1.2.2] +synonym: "H+-transporting ATPase activity" RELATED [EC:7.1.2.2] synonym: "hydrogen ion translocating A-type ATPase activity" NARROW [] synonym: "hydrogen ion translocating F-type ATPase activity" NARROW [] synonym: "hydrogen ion translocating V-type ATPase activity" NARROW [] synonym: "hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [] synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW [] -synonym: "mitochondrial ATPase activity" NARROW [EC:3.6.3.14] +synonym: "mitochondrial ATPase activity" NARROW [EC:7.1.2.2] +xref: EC:7.1.2.2 xref: MetaCyc:ATPSYN-RXN xref: RHEA:57721 is_a: GO:0009678 ! pyrophosphate hydrolysis-driven proton transmembrane transporter activity @@ -289412,7 +287474,7 @@ is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, r id: GO:0046962 name: sodium-transporting ATPase activity, rotational mechanism namespace: molecular_function -def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) => ADP + phosphate + Na+(out), by a rotational mechanism." [EC:7.2.2.1, RHEA:58157] +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) => ADP + phosphate + Na+(out), by a rotational mechanism." [RHEA:58157] synonym: "ATP phosphohydrolase (Na+-transporting) activity" RELATED [] synonym: "ATP synthase, sodium ion specific activity" EXACT [EC:7.2.2.1] synonym: "Na(+)-translocating ATPase activity" BROAD [] @@ -289715,6 +287777,7 @@ synonym: "arylhydroxamate N,O-acetyltransferase activity" EXACT [EC:2.3.1.118] synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" EXACT [EC:2.3.1.118] xref: EC:2.3.1.118 xref: MetaCyc:2.3.1.118-RXN +xref: RHEA:20277 is_a: GO:0016413 ! O-acetyltransferase activity [Term] @@ -290145,6 +288208,7 @@ synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" EXACT [EC synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201] xref: EC:1.1.1.201 xref: MetaCyc:1.1.1.201-RXN +xref: RHEA:20233 xref: Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+) is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -290191,6 +288255,7 @@ synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleot synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.1.1.212] xref: EC:1.1.1.212 xref: MetaCyc:1.1.1.212-RXN +xref: RHEA:19913 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -290571,6 +288636,7 @@ def: "Catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocy synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" EXACT [EC:1.1.2.5] xref: EC:1.1.2.5 xref: MetaCyc:1.1.2.5-RXN +xref: RHEA:16465 is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] @@ -290677,6 +288743,7 @@ synonym: "PVA dehydrogenase activity" BROAD [EC:1.1.99.23] xref: EC:1.1.2.6 xref: KEGG_REACTION:R03136 xref: MetaCyc:RXN-11316 +xref: RHEA:20157 is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] @@ -290728,6 +288795,7 @@ synonym: "ascorbate-cytochrome b5 reductase activity" EXACT [EC:1.10.2.1] synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.10.2.1] xref: EC:1.10.2.1 xref: MetaCyc:1.10.2.1-RXN +xref: RHEA:18677 is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor [Term] @@ -290773,6 +288841,7 @@ xref: Reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE" xref: Reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE" xref: Reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA" xref: Reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA" +xref: RHEA:19057 is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor [Term] @@ -290840,6 +288909,7 @@ synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizi synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.16] xref: EC:1.13.11.16 xref: MetaCyc:1.13.11.16-RXN +xref: RHEA:23840 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] @@ -290891,6 +288961,7 @@ namespace: molecular_function def: "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." [EC:1.13.11.-, MetaCyc:R308-RXN] xref: EC:1.13.11 xref: MetaCyc:RXN-10137 +xref: RHEA:35595 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] @@ -291133,7 +289204,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0047092 name: 27-hydroxycholesterol 7-alpha-monooxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [EC:1.14.14.29, MetaCyc:1.14.13.60-RXN, RHEA:24308] +def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [RHEA:24308] synonym: "27-hydroxycholesterol 7-alpha-hydroxylase activity" EXACT [EC:1.14.14.29] synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT [] synonym: "27-hydroxycholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.14.29] @@ -291274,6 +289345,7 @@ synonym: "2-oxoisovalerate dehydrogenase activity" EXACT [EC:1.2.1.25] synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" EXACT [EC:1.2.1.25] xref: EC:1.2.1.25 xref: MetaCyc:1.2.1.25-RXN +xref: RHEA:13997 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -291444,6 +289516,7 @@ synonym: "aldehyde dehydrogenase (pyrroloquinoline-quinone)" RELATED [] synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" EXACT [EC:1.2.99.3] xref: EC:1.2.5.2 xref: MetaCyc:1.2.99.3-RXN +xref: RHEA:13881 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] @@ -291712,6 +289785,7 @@ def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine. synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.12] xref: EC:1.5.3.12 xref: MetaCyc:1.5.3.12-RXN +xref: RHEA:16621 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] @@ -291723,6 +289797,7 @@ synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activi synonym: "DMADh activity" RELATED [EC:1.5.8.1] xref: EC:1.5.8.1 xref: MetaCyc:1.5.8.1-RXN +xref: RHEA:10204 xref: UM-BBD_reactionID:r1380 is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor @@ -291886,7 +289961,7 @@ is_a: GO:0016491 ! oxidoreductase activity id: GO:0047144 name: 2-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [EC:2.3.1.52, GOC:ab, MetaCyc:2-ACYL2.3.1.15-RXN, RHEA:14233] +def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [GOC:ab, RHEA:14233] synonym: "2-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.52] synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.52] xref: EC:2.3.1.52 @@ -291897,6 +289972,7 @@ xref: Reactome:R-HSA-1482626 "2-acyl LPI is acylated to PI by MBOAT7" xref: Reactome:R-HSA-1482635 "2-acyl LPG is acylated to PG by LPGAT" xref: Reactome:R-HSA-1482646 "2-acyl LPE is acylated to PE by LPEAT" xref: Reactome:R-HSA-1482691 "2-acyl LPS is acylated to PS by LPSAT" +xref: RHEA:14233 is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity @@ -291998,6 +290074,7 @@ synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxi xref: EC:2.1.1.74 xref: KEGG_REACTION:R03704 xref: MetaCyc:2.1.1.74-RXN +xref: RHEA:16873 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -292097,6 +290174,7 @@ synonym: "myelin PLP acyltransferase activity" EXACT [EC:2.3.1.100] synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100] xref: EC:2.3.1.100 xref: MetaCyc:2.3.1.100-RXN +xref: RHEA:14869 is_a: GO:0016416 ! O-palmitoyltransferase activity [Term] @@ -292235,6 +290313,7 @@ synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" EXACT [EC:2.3.1 synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.125] xref: EC:2.3.1.125 xref: MetaCyc:2.3.1.125-RXN +xref: RHEA:21996 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -292308,6 +290387,7 @@ synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acylt xref: EC:2.3.1.135 xref: MetaCyc:2.3.1.135-RXN xref: Reactome:R-HSA-975608 "LRAT esterifies RBP2:atROL and FACYLs to atREs" +xref: RHEA:17469 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -292338,6 +290418,7 @@ synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransf synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.141] xref: EC:2.3.1.141 xref: MetaCyc:2.3.1.141-RXN +xref: RHEA:17057 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -292364,6 +290445,7 @@ synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso- synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147] xref: EC:2.3.1.147 xref: MetaCyc:2.3.1.147-RXN +xref: RHEA:15409 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -292374,6 +290456,7 @@ def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" EXACT [EC:2.3.1.148] xref: EC:2.3.1.148 xref: MetaCyc:2.3.1.148-RXN +xref: RHEA:20972 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -292385,6 +290468,7 @@ synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero synonym: "PAF acetyltransferase activity" EXACT [] xref: EC:2.3.1.149 xref: MetaCyc:2.3.1.149-RXN +xref: RHEA:11048 is_a: GO:0016407 ! acetyltransferase activity [Term] @@ -292429,6 +290513,7 @@ def: "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoy synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.153] xref: EC:2.3.1.153 xref: MetaCyc:RXN-7945 +xref: RHEA:15661 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -292480,6 +290565,7 @@ synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" EXACT [EC:2 synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45] xref: EC:2.3.1.45 xref: MetaCyc:2.3.1.45-RXN +xref: RHEA:20808 is_a: GO:0016413 ! O-acetyltransferase activity [Term] @@ -292493,6 +290579,7 @@ synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" EXACT [EC:2.3.1.49] xref: EC:2.3.1.49 xref: MetaCyc:2.3.1.49-RXN +xref: RHEA:20393 is_a: GO:0016418 ! S-acetyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -292552,6 +290639,7 @@ def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.63] xref: EC:2.3.1.63 xref: MetaCyc:2.3.1.63-RXN +xref: RHEA:23992 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -292575,6 +290663,7 @@ synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67] synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67] xref: EC:2.3.1.67 xref: MetaCyc:2.3.1.67-RXN +xref: RHEA:18461 is_a: GO:0016413 ! O-acetyltransferase activity [Term] @@ -292614,6 +290703,7 @@ synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" EXACT [EC:2.3 synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" EXACT [EC:2.3.1.73] xref: EC:2.3.1.73 xref: MetaCyc:2.3.1.73-RXN +xref: RHEA:13301 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -292644,6 +290734,7 @@ synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" EXACT synonym: "triacylglycerol:sterol acyltransferase activity" EXACT [EC:2.3.1.77] xref: EC:2.3.1.77 xref: MetaCyc:2.3.1.77-RXN +xref: RHEA:16897 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -292859,6 +290950,7 @@ synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" EXACT [EC:2.4.1 synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] xref: EC:2.4.1.115 xref: MetaCyc:2.4.1.115-RXN +xref: RHEA:20093 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -292872,6 +290964,7 @@ synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltra synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116] xref: EC:2.4.1.116 xref: MetaCyc:2.4.1.116-RXN +xref: RHEA:12144 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -292971,6 +291064,7 @@ xref: EC:2.4.1.134 xref: MetaCyc:2.4.1.134-RXN xref: Reactome:R-HSA-1889978 "B3GALT6 transfers Gal to the tetrasaccharide linker" xref: Reactome:R-HSA-4420365 "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker" +xref: RHEA:11780 is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein @@ -293020,7 +291114,6 @@ xref: EC:2.4.1.146 xref: MetaCyc:2.4.1.146-RXN xref: Reactome:R-HSA-5617037 "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1" xref: Reactome:R-HSA-5617096 "Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1" -xref: RHEA:12227 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein @@ -293215,6 +291308,7 @@ synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminylt synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" EXACT [EC:2.4.1.174] xref: EC:2.4.1.174 xref: MetaCyc:2.4.1.174-RXN +xref: RHEA:23464 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] @@ -293463,6 +291557,7 @@ synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucos synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201] xref: EC:2.4.1.201 xref: MetaCyc:2.4.1.201-RXN +xref: RHEA:19945 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein @@ -293521,6 +291616,7 @@ synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" EXACT synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] xref: EC:2.4.1.208 xref: MetaCyc:2.4.1.208-RXN +xref: RHEA:19165 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -293597,6 +291693,7 @@ synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturo synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] xref: EC:2.4.1.43 xref: MetaCyc:2.4.1.43-RXN +xref: RHEA:13573 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -293638,6 +291735,7 @@ synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activi synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52] xref: EC:2.4.1.52 xref: MetaCyc:2.4.1.52-RXN +xref: RHEA:15845 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -293653,6 +291751,7 @@ synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53] xref: EC:2.4.1.53 xref: MetaCyc:2.4.1.53-RXN +xref: RHEA:10068 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -293689,6 +291788,7 @@ synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosam synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70] xref: EC:2.4.1.70 xref: MetaCyc:2.4.1.70-RXN +xref: RHEA:21012 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] @@ -293865,7 +291965,7 @@ is_a: GO:0035250 ! UDP-galactosyltransferase activity id: GO:0047280 name: nicotinamide phosphoribosyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide." [EC:2.4.2.12, RHEA:16149] +def: "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide." [RHEA:16149] synonym: "nicotinamide mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.12] synonym: "nicotinamide mononucleotide synthetase activity" EXACT [EC:2.4.2.12] synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.12] @@ -293891,6 +291991,7 @@ synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" EXA synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20] xref: EC:2.4.2.20 xref: MetaCyc:2.4.2.20-RXN +xref: RHEA:10232 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] @@ -293926,6 +292027,7 @@ def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolich synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" EXACT [EC:2.4.2.33] xref: EC:2.4.2.33 xref: MetaCyc:2.4.2.33-RXN +xref: RHEA:18361 is_a: GO:0042285 ! xylosyltransferase activity [Term] @@ -293951,6 +292053,7 @@ synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.36 xref: MetaCyc:RXN-11372 xref: Reactome:R-HSA-5336421 "DT fragment A ADP-ribosylates target cell EEF" +xref: RHEA:11820 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] @@ -294061,6 +292164,7 @@ synonym: "p-hydroxybenzoic-polyprenyl transferase activity" EXACT [EC:2.5.1.39] synonym: "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity" EXACT [EC:2.5.1.39] xref: EC:2.5.1.39 xref: MetaCyc:2.5.1.39-RXN +xref: RHEA:17709 is_a: GO:0002094 ! polyprenyltransferase activity [Term] @@ -294099,6 +292203,7 @@ def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2 synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" EXACT [EC:2.5.1.44] xref: EC:2.5.1.44 xref: MetaCyc:2.5.1.44-RXN +xref: RHEA:18645 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] @@ -294112,6 +292217,7 @@ synonym: "asparagine-oxo-acid aminotransferase activity" EXACT [] synonym: "L-asparagine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14] xref: EC:2.6.1.14 xref: MetaCyc:2.6.1.14-RXN +xref: RHEA:19813 is_a: GO:0008483 ! transaminase activity [Term] @@ -294375,6 +292481,7 @@ xref: EC:2.6.1.58 xref: KEGG_REACTION:R00692 xref: MetaCyc:2.6.1.58-RXN xref: Reactome:R-HSA-893593 "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine" +xref: RHEA:13053 is_a: GO:0070546 ! L-phenylalanine aminotransferase activity [Term] @@ -294387,6 +292494,7 @@ synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60] xref: EC:2.6.1.60 xref: MetaCyc:2.6.1.60-RXN +xref: RHEA:10900 is_a: GO:0008483 ! transaminase activity [Term] @@ -294496,6 +292604,7 @@ synonym: "reductase kinase activity" BROAD [EC:2.7.11.31] synonym: "STK29" RELATED [EC:2.7.11.31] xref: EC:2.7.11.31 xref: MetaCyc:2.7.1.109-RXN +xref: RHEA:23172 is_a: GO:0004672 ! protein kinase activity [Term] @@ -294517,6 +292626,7 @@ synonym: "STK2" RELATED [EC:2.7.11.4] xref: EC:2.7.11.4 xref: MetaCyc:2.7.11.4-RXN xref: Reactome:R-HSA-5693148 "BCKDK phosphorylates BCKDH" +xref: RHEA:17301 is_a: GO:0004672 ! protein kinase activity [Term] @@ -294589,6 +292699,7 @@ synonym: "acyl-phosphate:D-hexose phosphotransferase activity" EXACT [EC:2.7.1.6 synonym: "hexose phosphate:hexose phosphotransferase activity" EXACT [EC:2.7.1.61] xref: EC:2.7.1.61 xref: MetaCyc:2.7.1.61-RXN +xref: RHEA:13077 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor @@ -294617,6 +292728,7 @@ synonym: "polyphosphate-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.6 synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63] xref: EC:2.7.1.63 xref: MetaCyc:2.7.1.63-RXN +xref: RHEA:22036 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor @@ -294695,6 +292807,7 @@ synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activ synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] xref: EC:2.7.4.17 xref: MetaCyc:2.7.4.17-RXN +xref: RHEA:18665 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] @@ -294719,6 +292832,7 @@ synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" EXACT synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20] xref: EC:2.7.4.20 xref: MetaCyc:2.7.4.20-RXN +xref: RHEA:19417 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] @@ -295019,6 +293133,7 @@ synonym: "teichoic acid glycerol transferase activity" EXACT [EC:2.7.8.12] synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12] xref: EC:2.7.8.12 xref: MetaCyc:2.7.8.12-RXN +xref: RHEA:13565 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] @@ -295036,6 +293151,7 @@ synonym: "teichoate synthetase activity" EXACT [EC:2.7.8.14] synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14] xref: EC:2.7.8.14 xref: MetaCyc:2.7.8.14-RXN +xref: RHEA:13353 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] @@ -295069,6 +293185,7 @@ synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity" synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19] xref: EC:2.7.8.19 xref: MetaCyc:2.7.8.19-RXN +xref: RHEA:20181 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] @@ -295080,6 +293197,7 @@ synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activi synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.22] xref: EC:2.7.8.22 xref: MetaCyc:2.7.8.22-RXN +xref: RHEA:21072 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] @@ -295132,6 +293250,7 @@ synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT [] synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" EXACT [EC:2.8.2.19] xref: EC:2.8.2.19 xref: MetaCyc:2.8.2.19-RXN +xref: RHEA:13273 is_a: GO:0008146 ! sulfotransferase activity [Term] @@ -295220,6 +293339,7 @@ synonym: "hydroxymethylglutarate coenzyme A-transferase activity" EXACT [EC:2.8. synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" EXACT [EC:2.8.3.13] xref: EC:2.8.3.13 xref: MetaCyc:2.8.3.13-RXN +xref: RHEA:12284 is_a: GO:0008410 ! CoA-transferase activity [Term] @@ -295276,6 +293396,7 @@ xref: Reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular panc xref: Reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG" xref: Reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL" xref: Reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG" +xref: RHEA:34019 is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity @@ -295326,7 +293447,7 @@ is_a: GO:0052689 ! carboxylic ester hydrolase activity id: GO:0047376 name: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity namespace: molecular_function -def: "Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate." [MetaCyc:3.1.1.64-RXN, RHEA:13933] +def: "Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate." [RHEA:13933] synonym: "all-trans-retinyl-palmitate acylhydrolase activity" BROAD [EC:3.1.1.64] synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD [EC:3.1.1.64] synonym: "retinyl-palmitate palmitohydrolase activity" BROAD [KEGG_REACTION:R02368] @@ -295416,6 +293537,7 @@ synonym: "lauryl-acyl-carrier protein hydrolase activity" EXACT [EC:3.1.2.21] synonym: "lauryl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21] xref: EC:3.1.2.21 xref: MetaCyc:3.1.2.21-RXN +xref: RHEA:30119 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] @@ -295514,6 +293636,7 @@ synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase ac xref: EC:2.7.7.89 xref: KEGG_REACTION:R03474 xref: MetaCyc:3.1.4.15-RXN +xref: RHEA:43716 is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -295557,6 +293680,7 @@ synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activit synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39] xref: EC:3.1.4.39 xref: MetaCyc:3.1.4.39-RXN +xref: RHEA:15965 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] @@ -295665,6 +293789,7 @@ synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity" synonym: "mannosylphosphodolichol phosphodiesterase activity" EXACT [EC:3.1.4.49] xref: EC:3.1.4.49 xref: MetaCyc:3.1.4.49-RXN +xref: RHEA:12989 is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] @@ -295676,6 +293801,7 @@ synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrol synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.51] xref: EC:3.1.4.51 xref: MetaCyc:3.1.4.51-RXN +xref: RHEA:18045 is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein @@ -295712,6 +293838,7 @@ synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysin synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" EXACT [EC:3.2.1.107] xref: EC:3.2.1.107 xref: MetaCyc:3.2.1.107-RXN +xref: RHEA:11068 is_a: GO:0015926 ! glucosidase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -295748,6 +293875,7 @@ synonym: "pyrimidine nucleotide N-ribosidase activity" EXACT [EC:3.2.2.10] synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" EXACT [EC:3.2.2.10] xref: EC:3.2.2.10 xref: MetaCyc:3.2.2.10-RXN +xref: RHEA:13425 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] @@ -295777,6 +293905,7 @@ synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [E synonym: "dinitrogenase reductase-activating glycohydrolase activity" EXACT [EC:3.2.2.24] xref: EC:3.2.2.24 xref: MetaCyc:3.2.2.24-RXN +xref: RHEA:14493 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] @@ -295788,6 +293917,7 @@ synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity" synonym: "lysoplasmalogenase activity" EXACT [EC:3.3.2.2] xref: EC:3.3.2.2 xref: MetaCyc:3.3.2.2-RXN +xref: RHEA:22544 is_a: GO:0016803 ! ether hydrolase activity [Term] @@ -295798,6 +293928,7 @@ def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanol synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" EXACT [EC:3.3.2.5] xref: EC:3.3.2.5 xref: MetaCyc:3.3.2.5-RXN +xref: RHEA:16905 is_a: GO:0016803 ! ether hydrolase activity [Term] @@ -295831,6 +293962,7 @@ synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT [] synonym: "N-acylethanolamine amidohydrolase activity" EXACT [] xref: EC:3.5.1.60 xref: MetaCyc:3.5.1.60-RXN +xref: RHEA:17505 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -295887,6 +294019,7 @@ synonym: "aralkyl acylamidase activity" EXACT [EC:3.5.1.76] synonym: "N-acetylarylalkylamine amidohydrolase activity" EXACT [EC:3.5.1.76] xref: EC:3.5.1.76 xref: MetaCyc:3.5.1.76-RXN +xref: RHEA:10352 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -295897,6 +294030,7 @@ def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D- synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.77] xref: EC:3.5.1.77 xref: MetaCyc:3.5.1.77-RXN +xref: RHEA:11000 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -295908,6 +294042,7 @@ synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79] synonym: "phthalyl-amide amidohydrolase activity" EXACT [EC:3.5.1.79] xref: EC:3.5.1.79 xref: MetaCyc:3.5.1.79-RXN +xref: RHEA:18297 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -295917,6 +294052,7 @@ namespace: molecular_function def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [EC:3.5.1.25, MetaCyc:3.5.1.80-RXN] xref: EC:3.5.1.25 xref: MetaCyc:3.5.1.80-RXN +xref: RHEA:18149 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity @@ -296056,6 +294192,7 @@ synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" EX synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT [] xref: EC:3.6.1.44 xref: MetaCyc:3.6.1.44-RXN +xref: RHEA:15205 is_a: GO:0016462 ! pyrophosphatase activity [Term] @@ -296380,7 +294517,7 @@ is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity id: GO:0047451 name: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function -def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN, PMID:8910376, RHEA:41844] +def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [PMID:8910376, RHEA:41844] synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.59] synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.59] synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.59] @@ -296674,6 +294811,7 @@ synonym: "malto-oligosyltrehalose synthase activity" EXACT [EC:5.4.99.15] synonym: "maltodextrin alpha-D-glucosyltransferase activity" EXACT [EC:5.4.99.15] xref: EC:5.4.99.15 xref: MetaCyc:5.4.99.15-RXN +xref: RHEA:13621 is_a: GO:0016866 ! intramolecular transferase activity [Term] @@ -296730,6 +294868,7 @@ synonym: "long-chain-fatty-acid-luciferin-component ligase activity" EXACT [] synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" EXACT [EC:6.2.1.19] xref: EC:6.2.1.19 xref: MetaCyc:6.2.1.19-RXN +xref: RHEA:20101 is_a: GO:0016878 ! acid-thiol ligase activity [Term] @@ -296932,6 +295071,7 @@ synonym: "PATE activity" EXACT [EC:4.2.2.9] synonym: "pectate exo-lyase activity" EXACT [EC:4.2.2.9] xref: EC:4.2.2.9 xref: MetaCyc:4.2.2.9-RXN +xref: RHEA:57104 is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] @@ -297279,6 +295419,7 @@ synonym: "beta-1,3-oligoglucan phosphorylase activity" EXACT [EC:2.4.1.30] synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" EXACT [EC:2.4.1.30] xref: EC:2.4.1.30 xref: MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN +xref: RHEA:16041 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -297308,6 +295449,7 @@ synonym: "xylan synthase activity" EXACT [EC:2.4.2.24] synonym: "xylan synthetase activity" EXACT [EC:2.4.2.24] xref: EC:2.4.2.24 xref: MetaCyc:RXN-9104 +xref: RHEA:15289 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016763 ! transferase activity, transferring pentosyl groups @@ -297390,6 +295532,7 @@ def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroi synonym: "16-hydroxysteroid 16-epimerase activity" EXACT [EC:5.1.99.2] xref: EC:5.1.99.2 xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN +xref: RHEA:15829 is_a: GO:0016854 ! racemase and epimerase activity [Term] @@ -297431,6 +295574,7 @@ synonym: "2,3-dihydroxybenzoylserine synthetase activity" EXACT [EC:6.3.2.14] synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" EXACT [EC:6.3.2.14] xref: EC:6.3.2.14 xref: MetaCyc:23-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN +xref: RHEA:30571 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] @@ -297523,6 +295667,7 @@ synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3] synonym: "acetolactate mutase activity" EXACT [EC:5.4.99.3] xref: EC:5.4.99.3 xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN +xref: RHEA:16361 is_a: GO:0016866 ! intramolecular transferase activity [Term] @@ -297596,6 +295741,7 @@ synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" EXACT [EC:3.2. synonym: "2-deoxy-alpha-glucosidase activity" EXACT [EC:3.2.1.112] xref: EC:3.2.1.112 xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN +xref: RHEA:15317 is_a: GO:0015926 ! glucosidase activity [Term] @@ -297657,7 +295803,7 @@ is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, id: GO:0047544 name: 2-hydroxybiphenyl 3-monooxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+)." [EC:1.14.13.44, RHEA:11996] +def: "Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+)." [RHEA:11996] synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.44] xref: EC:1.14.13.44 xref: KEGG_REACTION:R03964 @@ -297805,6 +295951,7 @@ synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" EXACT [EC:1.2. synonym: "KGOR activity" EXACT [EC:1.2.7.3] xref: EC:1.2.7.3 xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN +xref: RHEA:17297 is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] @@ -298030,6 +296177,7 @@ synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC synonym: "delta4-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.99.6] xref: EC:1.3.99.6 xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN +xref: RHEA:24172 is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] @@ -298080,6 +296228,7 @@ synonym: "delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] synonym: "delta1-steroid reductase activity" EXACT [EC:1.3.99.4] xref: EC:1.3.99.4 xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN +xref: RHEA:13329 xref: UM-BBD_enzymeID:e0712 is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors @@ -298411,6 +296560,7 @@ synonym: "6-oxotetrahydronicotinate dehydrogenase activity" EXACT [EC:1.3.7.1] synonym: "HNA reductase activity" EXACT [EC:1.3.7.1] xref: EC:1.3.7.1 xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN +xref: RHEA:17225 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] @@ -298479,6 +296629,7 @@ synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abe synonym: "trihexose diphospholipid abequosyltransferase activity" EXACT [EC:2.4.1.60] xref: EC:2.4.1.60 xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN +xref: RHEA:34183 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -298698,6 +296849,7 @@ synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phos synonym: "enoyl coenzyme A reductase activity" EXACT [EC:1.3.1.8] xref: EC:1.3.1.8 xref: MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN +xref: RHEA:22460 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -298707,7 +296859,7 @@ namespace: molecular_function alt_id: GO:0008778 alt_id: GO:0016291 alt_id: GO:0016292 -def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN] +def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [RHEA:16781] synonym: "acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.20] synonym: "acyl coenzyme A thioesterase activity" EXACT [EC:3.1.2.20] synonym: "acyl-CoA thioesterase activity" EXACT [] @@ -298716,7 +296868,6 @@ synonym: "acyl-CoA thioesterase II activity" NARROW [] synonym: "acyl-CoA thiolesterase activity" EXACT [] synonym: "thioesterase B" RELATED [EC:3.1.2.20] synonym: "thioesterase II" RELATED [EC:3.1.2.20] -xref: EC:3.1.2 xref: EC:3.1.2.20 xref: MetaCyc:ACYL-COA-HYDROLASE-RXN xref: Reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA" @@ -298755,6 +296906,7 @@ synonym: "palmitoyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28] synonym: "palmitoylcarnitine hydrolase activity" EXACT [EC:3.1.1.28] xref: EC:3.1.1.28 xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN +xref: RHEA:17101 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] @@ -298772,6 +296924,7 @@ synonym: "sn-2-monoacylglycerol kinase activity" EXACT [EC:2.7.1.94] xref: EC:2.7.1.94 xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN xref: Reactome:R-HSA-5696074 "AGK:Mg2+ phosphorylates MAG, DAG" +xref: RHEA:19293 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor @@ -298783,6 +296936,7 @@ def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruva synonym: "3-acylpyruvate acylhydrolase activity" EXACT [EC:3.7.1.5] xref: EC:3.7.1.5 xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN +xref: RHEA:19009 xref: UM-BBD_reactionID:r1401 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances @@ -298880,6 +297034,7 @@ synonym: "ADP:dThd phosphotransferase activity" EXACT [EC:2.7.1.118] synonym: "ADP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.118] xref: EC:2.7.1.118 xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN +xref: RHEA:13413 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor @@ -298986,6 +297141,7 @@ synonym: "L-alanine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12] synonym: "leucine-alanine transaminase activity" EXACT [EC:2.6.1.12] xref: EC:2.6.1.12 xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN +xref: RHEA:19953 is_a: GO:0008483 ! transaminase activity [Term] @@ -299016,6 +297172,7 @@ synonym: "L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity" EXACT [ synonym: "O-alanylphosphatidylglycerol synthase activity" EXACT [EC:2.3.2.11] xref: EC:2.3.2.11 xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN +xref: RHEA:20489 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] @@ -299056,6 +297213,7 @@ synonym: "D-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.121] synonym: "dehydrogenase, D-aldohexose" EXACT [EC:1.1.1.121] xref: EC:1.1.1.121 xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN +xref: RHEA:15917 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -299097,6 +297255,7 @@ synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" EXACT [EC synonym: "mannuronosyl transferase activity" EXACT [EC:2.4.1.33] xref: EC:2.4.1.33 xref: MetaCyc:ALGINATE-SYNTHASE-RXN +xref: RHEA:46876 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -299138,6 +297297,7 @@ synonym: "bacterial luciferase activity" EXACT [EC:1.14.14.3] synonym: "vibrio fischeri luciferase activity" EXACT [EC:1.14.14.3] xref: EC:1.14.14.3 xref: MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN +xref: RHEA:17181 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] @@ -299250,6 +297410,7 @@ synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-form synonym: "S-alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] xref: EC:4.4.1.4 xref: MetaCyc:ALLIIN-LYASE-RXN +xref: RHEA:20141 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] @@ -299290,6 +297451,7 @@ synonym: "UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activit synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.183] xref: EC:2.4.1.183 xref: MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN +xref: RHEA:19749 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -299305,6 +297467,7 @@ synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" EXACT [EC:3.1.1.43 xref: EC:3.1.1.43 xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN xref: Reactome:R-HSA-6784959 "BPHL hydrolyses VACV to ACV" +xref: RHEA:17241 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] @@ -299351,6 +297514,7 @@ synonym: "aminobenzoate carboxy-lyase (aniline-forming)" EXACT [EC:4.1.1.24] synonym: "aminobenzoate carboxy-lyase activity" EXACT [EC:4.1.1.24] xref: EC:4.1.1.24 xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN +xref: RHEA:24200 is_a: GO:0016831 ! carboxy-lyase activity [Term] @@ -299375,7 +297539,7 @@ is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity id: GO:0047664 name: aminoimidazolase activity namespace: molecular_function -def: "Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH(3)." [EC:3.5.4.8, MetaCyc:AMINOIMIDAZOLASE-RXN, RHEA:22348] +def: "Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH(3)." [RHEA:22348] synonym: "4-aminoimidazole aminohydrolase activity" EXACT [EC:3.5.4.8] synonym: "4-aminoimidazole hydrolase activity" EXACT [EC:3.5.4.8] xref: EC:3.5.4.8 @@ -299441,6 +297605,7 @@ synonym: "AMP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] synonym: "thymidine phosphotransferase activity" EXACT [EC:2.7.1.114] xref: EC:2.7.1.114 xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN +xref: RHEA:14913 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor @@ -299472,6 +297637,7 @@ synonym: "sucrose-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4] synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.4] xref: EC:2.4.1.4 xref: MetaCyc:AMYLOSUCRASE-RXN +xref: RHEA:24572 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -299634,6 +297800,7 @@ synonym: "aryl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.91] synonym: "NADPH-linked benzaldehyde reductase activity" EXACT [EC:1.1.1.91] xref: EC:1.1.1.91 xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN +xref: RHEA:17761 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -299647,6 +297814,7 @@ synonym: "aryl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.7] synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7] xref: EC:1.1.3.7 xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN +xref: RHEA:17541 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] @@ -299658,6 +297826,7 @@ synonym: "aromatic acid reductase activity" EXACT [EC:1.2.1.30] synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" EXACT [EC:1.2.1.30] xref: EC:1.2.1.30 xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:19229 is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity [Term] @@ -299684,6 +297853,7 @@ synonym: "amine sulphotransferase activity" EXACT [] synonym: "arylamine sulfotransferase activity" EXACT [] xref: EC:2.8.2.3 xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN +xref: RHEA:24136 is_a: GO:0008146 ! sulfotransferase activity [Term] @@ -299698,6 +297868,7 @@ synonym: "arylsulphate sulphotransferase activity" EXACT [] synonym: "ASST" RELATED [EC:2.8.2.22] xref: EC:2.8.2.22 xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN +xref: RHEA:51072 is_a: GO:0008146 ! sulfotransferase activity [Term] @@ -299856,6 +298027,7 @@ synonym: "STK15" RELATED [EC:2.7.11.15] xref: EC:2.7.11.15 xref: Reactome:R-HSA-8851797 "ADRB2 in ADRB2:GRK complex is phosphorylated" xref: Reactome:R-HSA-8866268 "ADBRK1,2 phosphorylate AVPR2" +xref: RHEA:19429 is_a: GO:0004672 ! protein kinase activity [Term] @@ -299967,6 +298139,7 @@ synonym: "bile-salt sulphotransferase activity" EXACT [] synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14] xref: EC:2.8.2.14 xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN +xref: RHEA:14013 is_a: GO:0008146 ! sulfotransferase activity [Term] @@ -300264,6 +298437,7 @@ synonym: "sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.9] synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.9] xref: EC:2.4.1.9 xref: MetaCyc:INULOSUCRASE-RXN +xref: RHEA:15745 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -300583,7 +298757,7 @@ is_a: GO:0016878 ! acid-thiol ligase activity id: GO:0047748 name: cholestanetetraol 26-dehydrogenase activity namespace: molecular_function -def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN, RHEA:34631] +def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [RHEA:34631] synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT [] synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT [] synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT [] @@ -300702,6 +298876,7 @@ synonym: "chondroitin 4-sulphotransferase activity" EXACT [] xref: EC:2.8.2.5 xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN xref: Reactome:R-HSA-1971483 "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13" +xref: RHEA:16101 is_a: GO:0034481 ! chondroitin sulfotransferase activity [Term] @@ -301001,6 +299176,7 @@ synonym: "citrate-(pro-3S)-lyase thiolesterase activity" EXACT [EC:3.1.2.16] synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" EXACT [EC:3.1.2.16] xref: EC:3.1.2.16 xref: MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN +xref: RHEA:13657 is_a: GO:0016790 ! thiolester hydrolase activity [Term] @@ -301074,6 +299250,7 @@ synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5] synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" EXACT [EC:1.14.15.5] xref: EC:1.14.15.5 xref: MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN +xref: RHEA:11872 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] @@ -301314,6 +299491,7 @@ synonym: "cyclohexaglucanase activity" EXACT [EC:3.2.1.54] synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" EXACT [EC:3.2.1.54] xref: EC:3.2.1.54 xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN +xref: RHEA:23980 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -301400,6 +299578,7 @@ synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" EXACT [EC:4 synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.13] xref: EC:4.4.1.13 xref: MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN +xref: RHEA:18121 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] @@ -301433,6 +299612,7 @@ synonym: "H2:ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1] synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" EXACT [EC:1.12.2.1] xref: EC:1.12.2.1 xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN +xref: RHEA:20625 xref: UM-BBD_enzymeID:e0481 is_a: GO:0016697 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor @@ -301563,7 +299743,7 @@ is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0047816 -name: D-arabinose 1-dehydrogenase (NAD) activity +name: D-arabinose 1-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN] synonym: "arabinose(fucose)dehydrogenase activity" EXACT [EC:1.1.1.116] @@ -301664,6 +299844,7 @@ synonym: "D-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1] synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" EXACT [EC:2.3.2.1] xref: EC:2.3.2.1 xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN +xref: RHEA:35623 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] @@ -301816,6 +299997,7 @@ synonym: "L-fucose (D-arabinose) dehydrogenase activity" EXACT [EC:1.1.1.122] synonym: "L-fucose dehydrogenase activity" EXACT [EC:1.1.1.122] xref: EC:1.1.1.122 xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN +xref: RHEA:19645 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -301987,6 +300169,7 @@ synonym: "3'-deoxyribonucleotidase activity" EXACT [EC:3.1.3.34] synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.34] xref: EC:3.1.3.34 xref: MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN +xref: RHEA:10092 is_a: GO:0016791 ! phosphatase activity [Term] @@ -302058,6 +300241,7 @@ synonym: "carboxylyl-CoA synthetase activity" EXACT [EC:6.2.1.23] synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.23] xref: EC:6.2.1.23 xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN +xref: RHEA:14289 is_a: GO:0016878 ! acid-thiol ligase activity [Term] @@ -302071,6 +300255,7 @@ synonym: "transferrin reductase activity" EXACT [EC:1.16.1.2] synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.2] xref: EC:1.16.1.2 xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN +xref: RHEA:13841 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] @@ -302349,6 +300534,7 @@ synonym: "acyl-CoA:dolichol acyltransferase activity" EXACT [EC:2.3.1.123] synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" EXACT [EC:2.3.1.123] xref: EC:2.3.1.123 xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN +xref: RHEA:16685 is_a: GO:0008374 ! O-acyltransferase activity [Term] @@ -302412,6 +300598,7 @@ synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" EX synonym: "oligoglycosylglucosylceramide glycohydrolase activity" EXACT [EC:3.2.1.123] xref: EC:3.2.1.123 xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN +xref: RHEA:22288 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -302595,6 +300782,7 @@ synonym: "nitrate (ferredoxin) reductase activity" EXACT [EC:1.7.7.2] synonym: "nitrite:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.2] xref: EC:1.7.7.2 xref: MetaCyc:1.7.7.2-RXN +xref: RHEA:21828 is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor [Term] @@ -302638,6 +300826,7 @@ synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity" synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25] xref: EC:2.4.2.25 xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN +xref: RHEA:19153 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016763 ! transferase activity, transferring pentosyl groups @@ -302723,6 +300912,7 @@ synonym: "formate:cytochrome b1 oxidoreductase activity" EXACT [EC:1.2.2.1] synonym: "formate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.1] xref: EC:1.2.2.1 xref: MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:21520 is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] @@ -302854,6 +301044,7 @@ synonym: "N5-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48] synonym: "ornithine esterase activity" EXACT [EC:3.1.1.48] xref: EC:3.1.1.48 xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN +xref: RHEA:20165 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] @@ -302894,6 +301085,7 @@ synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" EXACT [ synonym: "poly(galacturonate) hydrolase activity" EXACT [EC:3.2.1.67] xref: EC:3.2.1.67 xref: MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN +xref: RHEA:14117 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -302939,6 +301131,7 @@ synonym: "gamma-glutaminylhistamine synthetase activity" EXACT [EC:6.3.2.18] synonym: "L-glutamate:histamine ligase activity" EXACT [EC:6.3.2.18] xref: EC:6.3.2.18 xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN +xref: RHEA:18881 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] @@ -303416,6 +301609,7 @@ def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutami synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" EXACT [EC:2.3.1.68] xref: EC:2.3.1.68 xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN +xref: RHEA:18469 is_a: GO:0016410 ! N-acyltransferase activity [Term] @@ -303488,7 +301682,7 @@ id: GO:0047952 name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity namespace: molecular_function alt_id: GO:0036439 -def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN, RHEA:11096] +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [RHEA:11096] synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.1.1.94] synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT [] synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.94] @@ -303596,6 +301790,7 @@ synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" EXACT [EC:1.4. synonym: "reductase, glycine-cytochrome c" EXACT [EC:1.4.2.1] xref: EC:1.4.2.1 xref: MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:16909 is_a: GO:0016640 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor [Term] @@ -303620,6 +301815,7 @@ synonym: "glycine-N-acylase activity" EXACT [EC:2.3.1.13] xref: EC:2.3.1.13 xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN xref: Reactome:R-HSA-2534040 "Unknown NAT N-acylates Gly in GNAT1" +xref: RHEA:19869 is_a: GO:0016410 ! N-acyltransferase activity [Term] @@ -304233,7 +302429,7 @@ is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling path id: GO:0048010 name: vascular endothelial growth factor receptor signaling pathway namespace: biological_process -def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling, PR:000001971] +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'. synonym: "VEGF receptor signaling pathway" EXACT [] synonym: "VEGF receptor signalling pathway" EXACT [] @@ -304568,18 +302764,18 @@ relationship: part_of GO:0007420 ! brain development [Term] id: GO:0048037 -name: cofactor binding +name: obsolete cofactor binding namespace: molecular_function -def: "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] -subset: goslim_pir -is_a: GO:0005488 ! binding +def: "OBSOLETE. Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a cofactor. +is_obsolete: true [Term] id: GO:0048038 name: quinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732] -is_a: GO:0048037 ! cofactor binding +is_a: GO:0005488 ! binding [Term] id: GO:0048039 @@ -305560,7 +303756,7 @@ is_a: GO:0022605 ! mammalian oogenesis stage id: GO:0048167 name: regulation of synaptic plasticity namespace: biological_process -def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, http://www.mercksource.com, PMID:11891290] +def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0050804 ! modulation of chemical synaptic transmission is_a: GO:0065008 ! regulation of biological quality @@ -305569,7 +303765,7 @@ is_a: GO:0065008 ! regulation of biological quality id: GO:0048168 name: regulation of neuronal synaptic plasticity namespace: biological_process -def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] +def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0048167 ! regulation of synaptic plasticity @@ -305577,7 +303773,7 @@ is_a: GO:0048167 ! regulation of synaptic plasticity id: GO:0048169 name: regulation of long-term neuronal synaptic plasticity namespace: biological_process -def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] +def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0048168 ! regulation of neuronal synaptic plasticity @@ -305585,7 +303781,7 @@ is_a: GO:0048168 ! regulation of neuronal synaptic plasticity id: GO:0048170 name: positive regulation of long-term neuronal synaptic plasticity namespace: biological_process -def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] +def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "activation of long-term neuronal synaptic plasticity" NARROW [] synonym: "stimulation of long-term neuronal synaptic plasticity" NARROW [] @@ -305599,7 +303795,7 @@ is_a: GO:0050769 ! positive regulation of neurogenesis id: GO:0048171 name: negative regulation of long-term neuronal synaptic plasticity namespace: biological_process -def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, http://www.mercksource.com, PMID:11891290] +def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "down regulation of long-term neuronal synaptic plasticity" EXACT [] synonym: "down-regulation of long-term neuronal synaptic plasticity" EXACT [] @@ -305612,7 +303808,7 @@ is_a: GO:0050768 ! negative regulation of neurogenesis id: GO:0048172 name: regulation of short-term neuronal synaptic plasticity namespace: biological_process -def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] +def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0048168 ! regulation of neuronal synaptic plasticity @@ -305620,7 +303816,7 @@ is_a: GO:0048168 ! regulation of neuronal synaptic plasticity id: GO:0048173 name: positive regulation of short-term neuronal synaptic plasticity namespace: biological_process -def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] +def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "activation of short-term neuronal synaptic plasticity" NARROW [] synonym: "stimulation of short-term neuronal synaptic plasticity" NARROW [] @@ -305634,7 +303830,7 @@ is_a: GO:0050769 ! positive regulation of neurogenesis id: GO:0048174 name: negative regulation of short-term neuronal synaptic plasticity namespace: biological_process -def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, http://www.mercksource.com, PMID:11891290] +def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. synonym: "down regulation of short-term neuronal synaptic plasticity" EXACT [] synonym: "down-regulation of short-term neuronal synaptic plasticity" EXACT [] @@ -305741,7 +303937,7 @@ relationship: part_of GO:0005887 ! integral component of plasma membrane id: GO:0048180 name: activin complex namespace: cellular_component -def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. subset: goslim_pir is_a: GO:0032991 ! protein-containing complex @@ -305751,7 +303947,7 @@ relationship: part_of GO:0005615 ! extracellular space id: GO:0048183 name: activin AB complex namespace: cellular_component -def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators] comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. synonym: "inhibin beta-A" NARROW [] synonym: "inhibin beta-B" NARROW [] @@ -306372,7 +304568,6 @@ def: "The chemical reactions and pathways involving lauric acid, a fatty acid wi synonym: "lauric acid metabolism" EXACT [] synonym: "n-dodecanoic acid metabolic process" EXACT [] synonym: "n-dodecanoic acid metabolism" EXACT [] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0051791 ! medium-chain fatty acid metabolic process [Term] @@ -306917,6 +305112,7 @@ def: "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + synonym: "ammonia:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.1] xref: EC:1.7.7.1 xref: MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN +xref: RHEA:18041 is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor is_a: GO:0098809 ! nitrite reductase activity @@ -312991,6 +311187,7 @@ synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4. synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] xref: EC:2.4.1.170 xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:56344 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -313579,6 +311776,7 @@ synonym: "delta7-sterol-C5(6)-desaturase activity" EXACT [EC:1.14.21.6] synonym: "lathosterol 5-desaturase activity" EXACT [EC:1.14.21.6] xref: EC:1.14.21.6 xref: MetaCyc:1.14.21.6-RXN +xref: RHEA:46556 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated is_a: GO:0070704 ! sterol desaturase activity @@ -313681,6 +311879,7 @@ synonym: "sucrose 6-fructosyltransferase activity" EXACT [EC:2.4.1.10] synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.10] xref: EC:2.4.1.10 xref: MetaCyc:LEVANSUCRASE-RXN +xref: RHEA:13653 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -313776,6 +311975,7 @@ synonym: "long-chain alcohol dehydrogenase activity" EXACT [EC:1.1.1.192] synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.192] xref: EC:1.1.1.192 xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN +xref: RHEA:17977 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -313789,6 +311989,7 @@ synonym: "long-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] xref: EC:1.2.1.48 xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN +xref: RHEA:10652 xref: UM-BBD_reactionID:r1404 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity @@ -313803,6 +312004,7 @@ synonym: "long-chain fatty acyl-CoA reductase activity" EXACT [GOC:mah] synonym: "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)" EXACT [EC:1.2.1.50] xref: EC:1.2.1.50 xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN +xref: RHEA:15437 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -313929,6 +312131,7 @@ synonym: "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity" EXACT synonym: "L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity" EXACT [EC:2.3.2.3] xref: EC:2.3.2.3 xref: MetaCyc:LYSYLTRANSFERASE-RXN +xref: RHEA:10668 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -313969,6 +312172,7 @@ synonym: "malyl coenzyme A synthetase activity" EXACT [EC:6.2.1.9] synonym: "malyl-CoA synthetase activity" EXACT [EC:6.2.1.9] xref: EC:6.2.1.9 xref: MetaCyc:MALATE--COA-LIGASE-RXN +xref: RHEA:26193 is_a: GO:0016878 ! acid-thiol ligase activity [Term] @@ -314140,6 +312344,7 @@ synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1. synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2] xref: EC:1.1.2.2 xref: MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:17597 is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] @@ -314354,6 +312559,7 @@ synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activi synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.49] xref: EC:2.4.1.49 xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN +xref: RHEA:23024 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -314366,6 +312572,7 @@ synonym: "dextran dextrinase activity" EXACT [EC:2.4.1.2] synonym: "dextrin 6-glucosyltransferase activity" EXACT [EC:2.4.1.2] xref: EC:2.4.1.2 xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN +xref: RHEA:14625 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -314768,6 +312975,7 @@ synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" EXACT [EC synonym: "N-methylamino acid oxidase activity" EXACT [EC:1.5.3.2] xref: EC:1.5.3.2 xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN +xref: RHEA:11472 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] @@ -314905,6 +313113,7 @@ synonym: "benzyl viologen-nitrate reductase activity" EXACT [EC:1.9.6.1] synonym: "ferrocytochrome:nitrate oxidoreductase activity" EXACT [EC:1.9.6.1] xref: EC:1.9.6.1 xref: MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN +xref: RHEA:12909 is_a: GO:0016677 ! oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor [Term] @@ -314926,6 +313135,7 @@ def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 ox synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" EXACT [EC:1.19.6.1] xref: EC:1.19.6.1 xref: MetaCyc:NITROGENASE-FLAVODOXIN-RXN +xref: RHEA:15645 is_a: GO:0016738 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor [Term] @@ -314995,6 +313205,7 @@ synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1. xref: EC:2.7.1.77 xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN xref: Reactome:R-HSA-2162066 "carbovir + IMP => carbovir monophosphate + inosine" +xref: RHEA:19961 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019205 ! nucleobase-containing compound kinase activity @@ -315021,6 +313232,7 @@ synonym: "nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4] synonym: "nucleotide pyrophosphokinase activity" EXACT [] xref: EC:2.7.6.4 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN +xref: RHEA:12713 is_a: GO:0016778 ! diphosphotransferase activity [Term] @@ -315035,6 +313247,7 @@ synonym: "isophenoxazine synthase activity" EXACT [EC:1.10.3.4] synonym: "o-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4] xref: EC:1.10.3.4 xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN +xref: RHEA:40963 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] @@ -315078,6 +313291,7 @@ synonym: "omega-amidodicarboxylate amidohydrolase activity" EXACT [EC:3.5.1.3] synonym: "w-amidase activity" EXACT [] xref: EC:3.5.1.3 xref: MetaCyc:OMEGA-AMIDASE-RXN +xref: RHEA:11716 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -315110,14 +313324,13 @@ is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor id: GO:0050155 name: ornithine(lysine) transaminase activity namespace: molecular_function -def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN, RHEA:23792] +def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN] synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT [] synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT [] synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT [] synonym: "ornithine(lysine) aminotransferase activity" EXACT [] xref: EC:2.6.1.13 xref: MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN -xref: RHEA:23792 is_a: GO:0008483 ! transaminase activity [Term] @@ -315319,6 +313532,7 @@ synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43] synonym: "peptidyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.43] xref: EC:3.5.1.43 xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN +xref: RHEA:10032 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -315373,8 +313587,8 @@ id: GO:0050174 name: phenylalanine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN] -synonym: "aromatic L-amino acid decarboxylase activity" EXACT [EC:4.1.1.53] -synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [EC:4.1.1.53] +synonym: "aromatic L-amino acid decarboxylase activity" BROAD [] +synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [] synonym: "L-phenylalanine carboxy-lyase activity" EXACT [EC:4.1.1.53] synonym: "L-phenylalanine decarboxylase activity" EXACT [EC:4.1.1.53] xref: EC:4.1.1.53 @@ -315862,13 +314076,10 @@ id: GO:0050208 name: polysialic-acid O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN] -synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [EC:2.3.1.136] -synonym: "lecithin retinol acyl transferase activity" EXACT [EC:2.3.1.136] -synonym: "lecithin:retinol acyltransferase activity" EXACT [EC:2.3.1.136] -synonym: "LRAT" RELATED [EC:2.3.1.136] -synonym: "retinyl ester synthase activity" EXACT [EC:2.3.1.136] +synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [] xref: EC:2.3.1.136 xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN +xref: RHEA:11604 is_a: GO:0016413 ! O-acetyltransferase activity [Term] @@ -315881,6 +314092,7 @@ synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.30] synonym: "PVA oxidase activity" EXACT [EC:1.1.3.30] xref: EC:1.1.3.30 xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN +xref: RHEA:21688 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] @@ -315914,6 +314126,7 @@ xref: EC:2.4.1.50 xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN xref: Reactome:R-HSA-1981120 "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2." xref: Reactome:R-HSA-1981128 "Galactosylation of collagen propeptide hydroxylysines by PLOD3" +xref: RHEA:12637 is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -316142,6 +314355,7 @@ synonym: "PAPS:psychosine sulphotransferase activity" EXACT [EC:2.8.2.13] synonym: "psychosine sulphotransferase activity" EXACT [] xref: EC:2.8.2.13 xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN +xref: RHEA:14137 is_a: GO:0008146 ! sulfotransferase activity [Term] @@ -316152,6 +314366,7 @@ def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-d synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.17.3.1] xref: EC:1.17.3.1 xref: MetaCyc:PTERIDINE-OXIDASE-RXN +xref: RHEA:12777 is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] @@ -316542,6 +314757,7 @@ synonym: "STK14" RELATED [EC:2.7.11.14] xref: EC:2.7.11.14 xref: MetaCyc:2.7.11.14-RXN xref: Reactome:R-HSA-2581474 "GRK1,4,7 phosphorylate MII to p-MII" +xref: RHEA:23356 is_a: GO:0004672 ! protein kinase activity [Term] @@ -316674,6 +314890,7 @@ synonym: "RihB" RELATED [EC:3.2.2.8] synonym: "YeiK" RELATED [EC:3.2.2.8] xref: EC:3.2.2.8 xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN +xref: RHEA:56816 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] @@ -316703,6 +314920,7 @@ synonym: "UTP:RNA uridylyltransferase activity" EXACT [] xref: EC:2.7.7.52 xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN xref: Reactome:R-HSA-8941312 "ZCCHC6, ZCCHC11 are mRNA uridyltransferases" +xref: RHEA:14785 is_a: GO:0070569 ! uridylyltransferase activity is_a: GO:0140098 ! catalytic activity, acting on RNA @@ -316734,6 +314952,7 @@ synonym: "rubber prenyltransferase activity" EXACT [EC:2.5.1.20] synonym: "rubber transferase activity" BROAD [EC:2.5.1.20] xref: EC:2.5.1.20 xref: MetaCyc:2.5.1.20-RXN +xref: RHEA:18801 is_a: GO:0002094 ! polyprenyltransferase activity [Term] @@ -317235,7 +315454,7 @@ is_a: GO:0018488 ! aryl-aldehyde oxidase activity id: GO:0050303 name: lysine 6-dehydrogenase activity namespace: molecular_function -def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN, RHEA:25117] +def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN, RHEA:12408] synonym: "L-lysine 6-dehydrogenase activity" EXACT [EC:1.4.1.18] synonym: "L-lysine epsilon-dehydrogenase activity" EXACT [EC:1.4.1.18] synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" EXACT [EC:1.4.1.18] @@ -317243,7 +315462,7 @@ synonym: "LysDH activity" EXACT [EC:1.4.1.18] xref: EC:1.4.1.18 xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN xref: MetaCyc:PWY-5314 -xref: RHEA:25125 +xref: RHEA:12408 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] @@ -317258,6 +315477,7 @@ synonym: "nitrous oxide reductase activity" EXACT [EC:1.7.2.4] xref: EC:1.7.2.4 xref: KEGG_REACTION:R02804 xref: MetaCyc:RXN-12130 +xref: RHEA:43108 is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] @@ -317339,6 +315559,7 @@ synonym: "sulfite:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.1] synonym: "sulphite dehydrogenase activity" EXACT [] xref: EC:1.8.2.1 xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN +xref: RHEA:14281 is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor [Term] @@ -317351,6 +315572,7 @@ synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" EXACT [EC:1.8.7.1 synonym: "sulphite reductase (ferredoxin) activity" EXACT [] xref: EC:1.8.7.1 xref: MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN +xref: RHEA:23132 is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor [Term] @@ -317375,6 +315597,7 @@ synonym: "sulphur dioxygenase activity" EXACT [] xref: EC:1.13.11.18 xref: MetaCyc:FESGSHTHIO-RXN xref: Reactome:R-HSA-1614605 "Persulfide sulfur is dioxygenated" +xref: RHEA:12981 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] @@ -317409,6 +315632,7 @@ def: "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP synonym: "ATP:(d)NMP phosphotransferase activity" EXACT [EC:2.7.4.12] xref: EC:2.7.4.12 xref: MetaCyc:GMKALT-RXN +xref: RHEA:12697 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor @@ -317725,6 +315949,7 @@ synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2 synonym: "thiosulphate dehydrogenase activity" EXACT [] xref: EC:1.8.2.2 xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN +xref: RHEA:20549 is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor [Term] @@ -317794,6 +316019,7 @@ def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NAD synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.44] xref: EC:1.3.1.44 xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN +xref: RHEA:18177 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -318192,6 +316418,7 @@ synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" EXACT [EC: synonym: "tyrosine 3-monooxygenase kinase activity" EXACT [] xref: EC:2.7.11.6 xref: MetaCyc:2.7.11.6-RXN +xref: RHEA:17133 is_a: GO:0004672 ! protein kinase activity [Term] @@ -318203,6 +316430,7 @@ synonym: "CYP79A1 activity" NARROW [] synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT [] synonym: "tyrosine N-hydroxylase activity" EXACT [] xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN +xref: RHEA:22464 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -318371,6 +316599,7 @@ namespace: molecular_function def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [EC:1.17.99.4, MetaCyc:URACIL-DEHYDROGENASE-RXN] xref: EC:1.17.99.4 xref: MetaCyc:URACIL-DEHYDROGENASE-RXN +xref: RHEA:22752 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] @@ -318578,6 +316807,7 @@ synonym: "wax-ester acylhydrolase activity" EXACT [EC:3.1.1.50] synonym: "WEH" RELATED [EC:3.1.1.50] xref: EC:3.1.1.50 xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN +xref: RHEA:13577 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] @@ -318689,6 +316919,7 @@ synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27] synonym: "STK5" RELATED [EC:2.7.11.27] xref: EC:2.7.11.27 xref: MetaCyc:2.7.11.27-RXN +xref: RHEA:20333 is_a: GO:0004672 ! protein kinase activity [Term] @@ -318700,6 +316931,7 @@ synonym: "acetyl-CoA carboxylase-phosphatase activity" EXACT [EC:3.1.3.44] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.44] xref: EC:3.1.3.44 xref: MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN +xref: RHEA:17125 is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] @@ -318922,6 +317154,7 @@ synonym: "NO-forming nitrite reductase activity" EXACT [] synonym: "Pseudomonas cytochrome oxidase activity" NARROW [EC:1.7.2.1] xref: EC:1.7.2.1 xref: MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN +xref: RHEA:15233 is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor is_a: GO:0098809 ! nitrite reductase activity @@ -318961,8 +317194,6 @@ def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine comment: This term was made obsolete because it represents a gene product. synonym: "alanine carboxypeptidase activity" EXACT [] synonym: "N-benzoyl-L-alanine-amidohydrolase activity" EXACT [EC:3.4.17.6] -xref: EC:3.4.17.6 -xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 @@ -318977,8 +317208,6 @@ synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2] synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" EXACT [EC:3.4.17.2] synonym: "protaminase activity" RELATED [EC:3.4.17.2] synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2] -xref: EC:3.4.17.2 -xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN is_obsolete: true replaced_by: GO:0004181 @@ -318994,8 +317223,6 @@ synonym: "peptidyl amino acid amide hydrolase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl carboxy-amidase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl carboxyamidase activity" EXACT [EC:3.4.19.2] synonym: "peptidyl-glycinamidase activity" EXACT [] -xref: EC:3.4.19.2 -xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN is_obsolete: true replaced_by: GO:0008242 @@ -319358,6 +317585,7 @@ synonym: "NADH2:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] synonym: "NADH:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] xref: EC:1.8.1.14 xref: MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN +xref: RHEA:14705 is_a: GO:0015036 ! disulfide oxidoreductase activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor @@ -319487,7 +317715,7 @@ synonym: "O-phosphorylethanol-amine phospho-lyase activity" EXACT [EC:4.2.3.2] xref: EC:4.2.3.2 xref: KEGG_REACTION:R00748 xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN -xref: Reactome:R-HSA-5696415 "ETNPPL tetramer hydrolyses PETA" +xref: Reactome:R-HSA-5696415 "PXLP-K278-ETNPPL tetramer hydrolyses PETA" xref: RHEA:17889 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates @@ -319653,6 +317881,7 @@ synonym: "TMADh activity" RELATED [EC:1.5.8.2] synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" EXACT [EC:1.5.8.2] xref: EC:1.5.8.2 xref: MetaCyc:1.5.8.2-RXN +xref: RHEA:11864 xref: UM-BBD_enzymeID:e0854 is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor @@ -319785,6 +318014,7 @@ synonym: "O-alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5] xref: EC:1.14.16.5 xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN xref: Reactome:R-HSA-5696119 "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol" +xref: RHEA:36255 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] @@ -319833,6 +318063,7 @@ def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai] synonym: "IMP 5' nucleotidase activity" EXACT [] synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED [] xref: MetaCyc:RXN-7607 +xref: RHEA:27718 is_a: GO:0008253 ! 5'-nucleotidase activity [Term] @@ -319843,6 +318074,7 @@ def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai] synonym: "GMP 5' nucleotidase activity" EXACT [] synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED [] xref: MetaCyc:RXN-7609 +xref: RHEA:27714 is_a: GO:0008253 ! 5'-nucleotidase activity [Term] @@ -319894,6 +318126,7 @@ synonym: "1,4-lactone hydroxyacylhydrolase activity" EXACT [EC:3.1.1.25] synonym: "gamma-lactonase activity" EXACT [EC:3.1.1.25] xref: EC:3.1.1.25 xref: MetaCyc:14-LACTONASE-RXN +xref: RHEA:12745 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] @@ -319916,6 +318149,7 @@ def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.261] xref: EC:1.1.1.261 xref: MetaCyc:1.1.1.261-RXN +xref: RHEA:21412 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -320014,6 +318248,7 @@ synonym: "spHAS" RELATED [EC:2.4.1.212] xref: EC:2.4.1.212 xref: MetaCyc:2.4.1.212-RXN xref: Reactome:R-HSA-2160851 "HAS1,2,3 mediate the polymerisation of HA" +xref: RHEA:12528 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -320115,6 +318350,7 @@ xref: Reactome:R-HSA-3656254 "Defective EXT2 (in EXT1:EXT2) does not transfer Gl xref: Reactome:R-HSA-3656261 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain" xref: Reactome:R-HSA-9036283 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue" xref: Reactome:R-HSA-9036290 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan" +xref: RHEA:16213 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] @@ -320134,6 +318370,7 @@ xref: Reactome:R-HSA-3656257 "Defective EXT1 (in EXT1:EXT2) does not transfer Gl xref: Reactome:R-HSA-3656267 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan" xref: Reactome:R-HSA-9036285 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan" xref: Reactome:R-HSA-9036289 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan" +xref: RHEA:20908 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] @@ -320164,6 +318401,7 @@ synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activ synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT [] xref: EC:2.4.1.227 xref: MetaCyc:RXN-8976 +xref: RHEA:23192 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] @@ -320292,6 +318530,7 @@ synonym: "CitX" RELATED [EC:2.7.7.61] synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61] xref: EC:2.7.7.61 xref: MetaCyc:2.7.7.61-RXN +xref: RHEA:16333 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] @@ -320321,6 +318560,7 @@ synonym: "GWD" RELATED [EC:2.7.9.4] synonym: "starch-related R1 protein activity" EXACT [EC:2.7.9.4] xref: EC:2.7.9.4 xref: MetaCyc:2.7.9.4-RXN +xref: RHEA:11668 is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors @@ -320385,6 +318625,7 @@ synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" EXACT [EC:3.1.1.75] synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75] xref: EC:3.1.1.75 xref: MetaCyc:3.1.1.75-RXN +xref: RHEA:11248 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] @@ -320414,6 +318655,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN] xref: EC:3.1.1.77 xref: MetaCyc:3.1.1.77-RXN +xref: RHEA:12032 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] @@ -320502,6 +318744,7 @@ synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl) synonym: "b-primeverosidase activity" EXACT [] xref: EC:3.2.1.149 xref: MetaCyc:3.2.1.149-RXN +xref: RHEA:24480 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -320539,6 +318782,7 @@ synonym: "L-carbamoylase activity" EXACT [EC:3.5.1.87] synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" EXACT [EC:3.5.1.87] xref: EC:3.5.1.87 xref: MetaCyc:3.5.1.87-RXN +xref: RHEA:17581 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -320756,6 +319000,7 @@ synonym: "epoxypropane:coenzyme M transferase activity" EXACT [EC:4.4.1.23] synonym: "epoxypropyl:CoM transferase activity" EXACT [EC:4.4.1.23] xref: EC:4.4.1.23 xref: MetaCyc:4.2.99.19-RXN +xref: RHEA:19421 xref: UM-BBD_enzymeID:e0538 is_a: GO:0016846 ! carbon-sulfur lyase activity @@ -320820,6 +319065,7 @@ synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" EXACT [EC:6.1.1.23] synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23] xref: EC:6.1.1.23 xref: MetaCyc:6.1.1.23-RXN +xref: RHEA:18349 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] @@ -320854,6 +319100,7 @@ synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" EXACT [EC:6.2.1.34] synonym: "trans-feruloyl-CoA synthetase activity" EXACT [EC:6.2.1.34] xref: EC:6.2.1.34 xref: MetaCyc:6.2.1.34-RXN +xref: RHEA:19389 is_a: GO:0016878 ! acid-thiol ligase activity [Term] @@ -320997,13 +319244,13 @@ is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, id: GO:0050573 name: dTDP-4-dehydro-6-deoxyglucose reductase activity namespace: molecular_function -def: "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH." [EC:1.1.1.266, RHEA:21903] +def: "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH." [EC:1.1.1.266, RHEA:36586] synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.1.1.266] synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.266] xref: EC:1.1.1.266 xref: KEGG_REACTION:R05687 xref: MetaCyc:1.1.1.266-RXN -xref: RHEA:21903 +xref: RHEA:36586 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -321060,6 +319307,7 @@ synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272] synonym: "L-sulfolactate dehydrogenase activity" EXACT [EC:1.1.1.272] xref: EC:1.1.1.272 xref: MetaCyc:1.1.1.272-RXN +xref: RHEA:35735 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -321431,6 +319679,7 @@ synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2] synonym: "rubredoxin:superoxide oxidoreductase activity" EXACT [EC:1.15.1.2] xref: EC:1.15.1.2 xref: MetaCyc:1.15.1.2-RXN +xref: RHEA:21324 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor @@ -321514,6 +319763,7 @@ synonym: "arsenite oxidase activity" EXACT [EC:1.20.9.1] synonym: "arsenite:azurin oxidoreductase activity" EXACT [EC:1.20.9.1] xref: EC:1.20.9.1 xref: MetaCyc:1.20.98.1-RXN +xref: RHEA:18701 xref: UM-BBD_reactionID:r0634 is_a: GO:0052882 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor @@ -321596,6 +319846,7 @@ def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = synonym: "PebA" RELATED [EC:1.3.7.2] xref: EC:1.3.7.2 xref: MetaCyc:1.3.7.2-RXN +xref: RHEA:10168 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] @@ -321607,6 +319858,7 @@ synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" EXACT [EC:1 synonym: "PebB" RELATED [EC:1.3.7.3] xref: EC:1.3.7.3 xref: MetaCyc:1.3.7.3-RXN +xref: RHEA:22092 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] @@ -321622,6 +319874,7 @@ synonym: "phytochromobilin synthase activity" EXACT [EC:1.3.7.4] synonym: "PPhiB synthase activity" EXACT [EC:1.3.7.4] xref: EC:1.3.7.4 xref: MetaCyc:1.3.7.4-RXN +xref: RHEA:16377 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] @@ -321632,6 +319885,7 @@ def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = bi synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.5] xref: EC:1.3.7.5 xref: MetaCyc:1.3.7.5-RXN +xref: RHEA:15309 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] @@ -321716,6 +319970,7 @@ synonym: "TOR activity" EXACT [EC:1.7.2.3] synonym: "trimethylamine:cytochrome c oxidoreductase activity" EXACT [EC:1.7.2.3] xref: EC:1.7.2.3 xref: MetaCyc:1.7.2.3-RXN +xref: RHEA:24236 xref: Wikipedia:Trimethylamine_N-oxide_reductase is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor @@ -321996,7 +320251,6 @@ name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0036041 ! long-chain fatty acid binding is_a: GO:0050542 ! icosanoid binding @@ -322166,7 +320420,6 @@ synonym: "FAD or FADH2 binding" EXACT [] synonym: "flavine-adenine dinucleotide binding" EXACT [] is_a: GO:0000166 ! nucleotide binding is_a: GO:0043168 ! anion binding -is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0050661 @@ -322177,15 +320430,14 @@ synonym: "NADP or NADPH binding" RELATED [GOC:mah] synonym: "NADP+ or NADPH binding" RELATED [] synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT [] is_a: GO:0000166 ! nucleotide binding -is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0050662 -name: coenzyme binding +name: obsolete coenzyme binding namespace: molecular_function -def: "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] -subset: goslim_metagenomics -is_a: GO:0048037 ! cofactor binding +def: "OBSOLETE. Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a coenzyme. +is_obsolete: true [Term] id: GO:0050663 @@ -322218,9 +320470,8 @@ synonym: "hydrogen peroxide biosynthesis" EXACT [] synonym: "hydrogen peroxide formation" EXACT [] synonym: "hydrogen peroxide generation" EXACT [] synonym: "hydrogen peroxide synthesis" EXACT [] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0042743 ! hydrogen peroxide metabolic process -is_a: GO:0051188 ! cofactor biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1903409 ! reactive oxygen species biosynthetic process [Term] @@ -322609,7 +320860,6 @@ synonym: "trichloroethylene catabolism" EXACT [] synonym: "trichloroethylene degradation" EXACT [] is_a: GO:0018979 ! trichloroethylene metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process -is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0050697 @@ -322645,66 +320895,6 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670] is_a: GO:0019904 ! protein domain specific binding -[Term] -id: GO:0050701 -name: interleukin-1 secretion -namespace: biological_process -def: "The regulated release of interleukin-1 from a cell. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response." [GOC:ai, ISBN:0198506732] -synonym: "IL-1 secretion" EXACT [] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032612 ! interleukin-1 production - -[Term] -id: GO:0050702 -name: interleukin-1 beta secretion -namespace: biological_process -def: "The regulated release of interleukin 1 beta from a cell." [GOC:ai] -synonym: "IL-1b secretion" EXACT [] -is_a: GO:0050701 ! interleukin-1 secretion -relationship: part_of GO:0032611 ! interleukin-1 beta production - -[Term] -id: GO:0050703 -name: interleukin-1 alpha secretion -namespace: biological_process -def: "The regulated release of interleukin-1 alpha from a cell." [GOC:ai] -synonym: "IL-1a secretion" EXACT [] -is_a: GO:0050701 ! interleukin-1 secretion -relationship: part_of GO:0032610 ! interleukin-1 alpha production - -[Term] -id: GO:0050704 -name: regulation of interleukin-1 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai] -is_a: GO:0032652 ! regulation of interleukin-1 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0050701 ! interleukin-1 secretion -relationship: regulates GO:0050701 ! interleukin-1 secretion - -[Term] -id: GO:0050705 -name: regulation of interleukin-1 alpha secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai] -is_a: GO:0032650 ! regulation of interleukin-1 alpha production -is_a: GO:0050704 ! regulation of interleukin-1 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0050703 ! interleukin-1 alpha secretion -relationship: regulates GO:0050703 ! interleukin-1 alpha secretion - -[Term] -id: GO:0050706 -name: regulation of interleukin-1 beta secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai] -is_a: GO:0032651 ! regulation of interleukin-1 beta production -is_a: GO:0050704 ! regulation of interleukin-1 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0050702 ! interleukin-1 beta secretion -relationship: regulates GO:0050702 ! interleukin-1 beta secretion - [Term] id: GO:0050707 name: regulation of cytokine secretion @@ -322765,54 +320955,6 @@ intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0050663 ! cytokine secretion relationship: negatively_regulates GO:0050663 ! cytokine secretion -[Term] -id: GO:0050711 -name: negative regulation of interleukin-1 secretion -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai] -synonym: "down regulation of interleukin-1 secretion" EXACT [] -synonym: "down-regulation of interleukin-1 secretion" EXACT [] -synonym: "downregulation of interleukin-1 secretion" EXACT [] -synonym: "inhibition of interleukin-1 secretion" NARROW [] -is_a: GO:0032692 ! negative regulation of interleukin-1 production -is_a: GO:0050704 ! regulation of interleukin-1 secretion -is_a: GO:0050710 ! negative regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0050701 ! interleukin-1 secretion -relationship: negatively_regulates GO:0050701 ! interleukin-1 secretion - -[Term] -id: GO:0050712 -name: negative regulation of interleukin-1 alpha secretion -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai] -synonym: "down regulation of interleukin-1 alpha secretion" EXACT [] -synonym: "down-regulation of interleukin-1 alpha secretion" EXACT [] -synonym: "downregulation of interleukin-1 alpha secretion" EXACT [] -synonym: "inhibition of interleukin-1 alpha secretion" NARROW [] -is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production -is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion -is_a: GO:0050711 ! negative regulation of interleukin-1 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion -relationship: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion - -[Term] -id: GO:0050713 -name: negative regulation of interleukin-1 beta secretion -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai] -synonym: "down regulation of interleukin-1 beta secretion" EXACT [] -synonym: "down-regulation of interleukin-1 beta secretion" EXACT [] -synonym: "downregulation of interleukin-1 beta secretion" EXACT [] -synonym: "inhibition of interleukin-1 beta secretion" NARROW [] -is_a: GO:0032691 ! negative regulation of interleukin-1 beta production -is_a: GO:0050706 ! regulation of interleukin-1 beta secretion -is_a: GO:0050711 ! negative regulation of interleukin-1 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0050702 ! interleukin-1 beta secretion -relationship: negatively_regulates GO:0050702 ! interleukin-1 beta secretion - [Term] id: GO:0050714 name: positive regulation of protein secretion @@ -322850,193 +320992,6 @@ intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0050663 ! cytokine secretion relationship: positively_regulates GO:0050663 ! cytokine secretion -[Term] -id: GO:0050716 -name: positive regulation of interleukin-1 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai] -synonym: "activation of interleukin-1 secretion" NARROW [] -synonym: "stimulation of interleukin-1 secretion" NARROW [] -synonym: "up regulation of interleukin-1 secretion" EXACT [] -synonym: "up-regulation of interleukin-1 secretion" EXACT [] -synonym: "upregulation of interleukin-1 secretion" EXACT [] -is_a: GO:0032732 ! positive regulation of interleukin-1 production -is_a: GO:0050704 ! regulation of interleukin-1 secretion -is_a: GO:0050715 ! positive regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0050701 ! interleukin-1 secretion -relationship: positively_regulates GO:0050701 ! interleukin-1 secretion - -[Term] -id: GO:0050717 -name: positive regulation of interleukin-1 alpha secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai] -synonym: "activation of interleukin-1 alpha secretion" NARROW [] -synonym: "stimulation of interleukin-1 alpha secretion" NARROW [] -synonym: "up regulation of interleukin-1 alpha secretion" EXACT [] -synonym: "up-regulation of interleukin-1 alpha secretion" EXACT [] -synonym: "upregulation of interleukin-1 alpha secretion" EXACT [] -is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production -is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion -is_a: GO:0050716 ! positive regulation of interleukin-1 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0050703 ! interleukin-1 alpha secretion -relationship: positively_regulates GO:0050703 ! interleukin-1 alpha secretion - -[Term] -id: GO:0050718 -name: positive regulation of interleukin-1 beta secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai] -synonym: "activation of interleukin-1 beta secretion" NARROW [] -synonym: "stimulation of interleukin-1 beta secretion" NARROW [] -synonym: "up regulation of interleukin-1 beta secretion" EXACT [] -synonym: "up-regulation of interleukin-1 beta secretion" EXACT [] -synonym: "upregulation of interleukin-1 beta secretion" EXACT [] -is_a: GO:0032731 ! positive regulation of interleukin-1 beta production -is_a: GO:0050706 ! regulation of interleukin-1 beta secretion -is_a: GO:0050716 ! positive regulation of interleukin-1 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0050702 ! interleukin-1 beta secretion -relationship: positively_regulates GO:0050702 ! interleukin-1 beta secretion - -[Term] -id: GO:0050719 -name: interleukin-1 alpha biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] -synonym: "interleukin-1 alpha anabolism" EXACT [] -synonym: "interleukin-1 alpha biosynthesis" EXACT [] -synonym: "interleukin-1 alpha formation" EXACT [] -synonym: "interleukin-1 alpha synthesis" EXACT [] -is_a: GO:0042222 ! interleukin-1 biosynthetic process -relationship: part_of GO:0032610 ! interleukin-1 alpha production - -[Term] -id: GO:0050720 -name: interleukin-1 beta biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] -synonym: "interleukin-1 beta anabolism" EXACT [] -synonym: "interleukin-1 beta biosynthesis" EXACT [] -synonym: "interleukin-1 beta formation" EXACT [] -synonym: "interleukin-1 beta synthesis" EXACT [] -is_a: GO:0042222 ! interleukin-1 biosynthetic process -relationship: part_of GO:0032611 ! interleukin-1 beta production - -[Term] -id: GO:0050721 -name: regulation of interleukin-1 alpha biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] -synonym: "regulation of interleukin-1 alpha anabolism" EXACT [] -synonym: "regulation of interleukin-1 alpha biosynthesis" EXACT [] -synonym: "regulation of interleukin-1 alpha formation" EXACT [] -synonym: "regulation of interleukin-1 alpha synthesis" EXACT [] -is_a: GO:0032650 ! regulation of interleukin-1 alpha production -is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process -relationship: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process - -[Term] -id: GO:0050722 -name: regulation of interleukin-1 beta biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] -synonym: "regulation of interleukin-1 beta anabolism" EXACT [] -synonym: "regulation of interleukin-1 beta biosynthesis" EXACT [] -synonym: "regulation of interleukin-1 beta formation" EXACT [] -synonym: "regulation of interleukin-1 beta synthesis" EXACT [] -is_a: GO:0032651 ! regulation of interleukin-1 beta production -is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0050720 ! interleukin-1 beta biosynthetic process -relationship: regulates GO:0050720 ! interleukin-1 beta biosynthetic process - -[Term] -id: GO:0050723 -name: negative regulation of interleukin-1 alpha biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] -synonym: "down regulation of interleukin-1 alpha biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-1 alpha biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-1 alpha biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-1 alpha biosynthetic process" NARROW [] -synonym: "negative regulation of interleukin-1 alpha anabolism" EXACT [] -synonym: "negative regulation of interleukin-1 alpha biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-1 alpha formation" EXACT [] -synonym: "negative regulation of interleukin-1 alpha synthesis" EXACT [] -is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production -is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process -is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process -relationship: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process - -[Term] -id: GO:0050724 -name: negative regulation of interleukin-1 beta biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] -synonym: "down regulation of interleukin-1 beta biosynthetic process" EXACT [] -synonym: "down-regulation of interleukin-1 beta biosynthetic process" EXACT [] -synonym: "downregulation of interleukin-1 beta biosynthetic process" EXACT [] -synonym: "inhibition of interleukin-1 beta biosynthetic process" NARROW [] -synonym: "negative regulation of interleukin-1 beta anabolism" EXACT [] -synonym: "negative regulation of interleukin-1 beta biosynthesis" EXACT [] -synonym: "negative regulation of interleukin-1 beta formation" EXACT [] -synonym: "negative regulation of interleukin-1 beta synthesis" EXACT [] -is_a: GO:0032691 ! negative regulation of interleukin-1 beta production -is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process -is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process -relationship: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process - -[Term] -id: GO:0050725 -name: positive regulation of interleukin-1 beta biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] -synonym: "activation of interleukin-1 beta biosynthetic process" NARROW [] -synonym: "positive regulation of interleukin-1 beta anabolism" EXACT [] -synonym: "positive regulation of interleukin-1 beta biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-1 beta formation" EXACT [] -synonym: "positive regulation of interleukin-1 beta synthesis" EXACT [] -synonym: "stimulation of interleukin-1 beta biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-1 beta biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-1 beta biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-1 beta biosynthetic process" EXACT [] -is_a: GO:0032731 ! positive regulation of interleukin-1 beta production -is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process -is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process -relationship: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process - -[Term] -id: GO:0050726 -name: positive regulation of interleukin-1 alpha biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] -synonym: "activation of interleukin-1 alpha biosynthetic process" NARROW [] -synonym: "positive regulation of interleukin-1 alpha anabolism" EXACT [] -synonym: "positive regulation of interleukin-1 alpha biosynthesis" EXACT [] -synonym: "positive regulation of interleukin-1 alpha formation" EXACT [] -synonym: "positive regulation of interleukin-1 alpha synthesis" EXACT [] -synonym: "stimulation of interleukin-1 alpha biosynthetic process" NARROW [] -synonym: "up regulation of interleukin-1 alpha biosynthetic process" EXACT [] -synonym: "up-regulation of interleukin-1 alpha biosynthetic process" EXACT [] -synonym: "upregulation of interleukin-1 alpha biosynthetic process" EXACT [] -is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production -is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process -is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process -relationship: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process - [Term] id: GO:0050727 name: regulation of inflammatory response @@ -323295,96 +321250,6 @@ synonym: "LDL receptor binding" EXACT [] synonym: "low-density lipoprotein receptor binding" EXACT [GOC:dph] is_a: GO:0070325 ! lipoprotein particle receptor binding -[Term] -id: GO:0050751 -name: fractalkine biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de] -synonym: "ABCD-3 biosynthesis" EXACT [] -synonym: "ABCD-3 biosynthetic process" EXACT [] -synonym: "CX3C membrane-anchored chemokine biosynthesis" EXACT [] -synonym: "CX3C membrane-anchored chemokine biosynthetic process" EXACT [] -synonym: "CX3CL1 biosynthesis" EXACT [] -synonym: "CX3CL1 biosynthetic process" EXACT [] -synonym: "fractalkine anabolism" EXACT [] -synonym: "fractalkine biosynthesis" EXACT [] -synonym: "fractalkine formation" EXACT [] -synonym: "fractalkine synthesis" EXACT [] -synonym: "neurotactin biosynthesis" EXACT [] -synonym: "neurotactin biosynthetic process" EXACT [] -is_a: GO:0042033 ! chemokine biosynthetic process -is_a: GO:0050756 ! fractalkine metabolic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0032603 ! fractalkine production - -[Term] -id: GO:0050752 -name: regulation of fractalkine biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] -synonym: "regulation of CX3CL1 biosynthesis" EXACT [] -synonym: "regulation of CX3CL1 biosynthetic process" EXACT [] -synonym: "regulation of fractalkine anabolism" EXACT [] -synonym: "regulation of fractalkine biosynthesis" EXACT [] -synonym: "regulation of fractalkine formation" EXACT [] -synonym: "regulation of fractalkine synthesis" EXACT [] -synonym: "regulation of neurotactin biosynthesis" EXACT [] -synonym: "regulation of neurotactin biosynthetic process" EXACT [] -is_a: GO:0032644 ! regulation of fractalkine production -is_a: GO:0045073 ! regulation of chemokine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0050751 ! fractalkine biosynthetic process -relationship: regulates GO:0050751 ! fractalkine biosynthetic process - -[Term] -id: GO:0050753 -name: negative regulation of fractalkine biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] -synonym: "down regulation of fractalkine biosynthetic process" EXACT [] -synonym: "down-regulation of fractalkine biosynthetic process" EXACT [] -synonym: "downregulation of fractalkine biosynthetic process" EXACT [] -synonym: "inhibition of fractalkine biosynthetic process" NARROW [] -synonym: "negative regulation of CX3CL1 biosynthesis" EXACT [] -synonym: "negative regulation of CX3CL1 biosynthetic process" EXACT [] -synonym: "negative regulation of fractalkine anabolism" EXACT [] -synonym: "negative regulation of fractalkine biosynthesis" EXACT [] -synonym: "negative regulation of fractalkine formation" EXACT [] -synonym: "negative regulation of fractalkine synthesis" EXACT [] -synonym: "negative regulation of neurotactin biosynthesis" EXACT [] -synonym: "negative regulation of neurotactin biosynthetic process" EXACT [] -is_a: GO:0032684 ! negative regulation of fractalkine production -is_a: GO:0045079 ! negative regulation of chemokine biosynthetic process -is_a: GO:0050752 ! regulation of fractalkine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0050751 ! fractalkine biosynthetic process -relationship: negatively_regulates GO:0050751 ! fractalkine biosynthetic process - -[Term] -id: GO:0050754 -name: positive regulation of fractalkine biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] -synonym: "activation of fractalkine biosynthetic process" NARROW [] -synonym: "positive regulation of CX3CL1 biosynthesis" EXACT [] -synonym: "positive regulation of CX3CL1 biosynthetic process" EXACT [] -synonym: "positive regulation of fractalkine anabolism" EXACT [] -synonym: "positive regulation of fractalkine biosynthesis" EXACT [] -synonym: "positive regulation of fractalkine formation" EXACT [] -synonym: "positive regulation of fractalkine synthesis" EXACT [] -synonym: "positive regulation of neurotactin biosynthesis" EXACT [] -synonym: "positive regulation of neurotactin biosynthetic process" EXACT [] -synonym: "stimulation of fractalkine biosynthetic process" NARROW [] -synonym: "up regulation of fractalkine biosynthetic process" EXACT [] -synonym: "up-regulation of fractalkine biosynthetic process" EXACT [] -synonym: "upregulation of fractalkine biosynthetic process" EXACT [] -is_a: GO:0032724 ! positive regulation of fractalkine production -is_a: GO:0045080 ! positive regulation of chemokine biosynthetic process -is_a: GO:0050752 ! regulation of fractalkine biosynthetic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0050751 ! fractalkine biosynthetic process -relationship: positively_regulates GO:0050751 ! fractalkine biosynthetic process - [Term] id: GO:0050755 name: chemokine metabolic process @@ -323771,7 +321636,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732] synonym: "cocaine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046448 ! tropane alkaloid metabolic process @@ -323785,7 +321649,6 @@ synonym: "cocaine catabolism" EXACT [] synonym: "cocaine degradation" EXACT [] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0019439 ! aromatic compound catabolic process -is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0050783 ! cocaine metabolic process @@ -323873,7 +321736,7 @@ namespace: biological_process def: "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb] synonym: "regulation of viral process" BROAD [] synonym: "regulation of viral reproduction" NARROW [GOC:bf, GOC:jl] -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016032 ! viral process relationship: regulates GO:0016032 ! viral process @@ -324127,7 +321990,6 @@ synonym: "regulation of acyl-CoA synthesis" EXACT [] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0071616 ! acyl-CoA biosynthetic process @@ -324456,8 +322318,6 @@ synonym: "S-adenosylmethionine breakdown" EXACT [] synonym: "S-adenosylmethionine catabolism" EXACT [] synonym: "S-adenosylmethionine degradation" EXACT [] synonym: "SAM catabolic process" EXACT [] -is_a: GO:0009109 ! coenzyme catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046500 ! S-adenosylmethionine metabolic process is_a: GO:1901575 ! organic substance catabolic process @@ -326472,6 +324332,7 @@ synonym: "squalene mutase (cyclizing)" EXACT [EC:5.4.99.17] synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581] xref: EC:5.4.99.17 xref: MetaCyc:5.4.99.17-RXN +xref: RHEA:17637 is_a: GO:0016866 ! intramolecular transferase activity is_a: GO:0034072 ! squalene cyclase activity @@ -326488,6 +324349,7 @@ name: O-acetylhomoserine sulfhydrylase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN, RHEA:27822] xref: MetaCyc:ACETYLHOMOSER-CYS-RXN +xref: RHEA:27822 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] @@ -326660,7 +324522,7 @@ namespace: biological_process def: "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [PMID:23396135] is_a: GO:0022607 ! cellular component assembly is_a: GO:1903046 ! meiotic cell cycle process -relationship: part_of GO:0007129 ! synapsis +relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] @@ -327103,6 +324965,7 @@ namespace: molecular_function def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN] synonym: "ADP reduction" RELATED [] xref: MetaCyc:ADPREDUCT-RXN +xref: RHEA:28034 is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Term] @@ -327112,6 +324975,7 @@ namespace: molecular_function def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN] synonym: "UDP reduction" RELATED [] xref: MetaCyc:UDPREDUCT-RXN +xref: RHEA:28026 is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [Term] @@ -327174,7 +325038,6 @@ synonym: "dihydrothioctamide metabolic process" EXACT [] synonym: "dihydrothioctamide metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process -is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] @@ -327236,6 +325099,7 @@ synonym: "cobalamin-5'-phosphate synthase activity" EXACT [EC:2.7.8.26] synonym: "CobS" RELATED [EC:2.7.8.26] xref: EC:2.7.8.26 xref: MetaCyc:COBALAMINSYN-RXN +xref: RHEA:16049 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] @@ -327332,6 +325196,7 @@ synonym: "glycoprotein-specific chaperone activity" NARROW [] synonym: "histone-specific chaperone activity" NARROW [] synonym: "ribosomal chaperone activity" NARROW [] synonym: "tubulin-specific chaperone activity" NARROW [] +xref: Reactome:R-HSA-9683772 "Trimmed spike protein binds to calnexin" is_a: GO:0005515 ! protein binding [Term] @@ -328627,75 +326492,71 @@ is_a: GO:0006810 ! transport [Term] id: GO:0051181 -name: cofactor transport +name: obsolete cofactor transport namespace: biological_process -def: "The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] -subset: goslim_pir +def: "OBSOLETE. The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a cofactor. synonym: "vitamin or cofactor transport" BROAD [] -is_a: GO:0006810 ! transport +is_obsolete: true [Term] id: GO:0051182 -name: coenzyme transport +name: obsolete coenzyme transport namespace: biological_process -def: "The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] -is_a: GO:0051181 ! cofactor transport +def: "OBSOLETE. The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a coenzyme. +is_obsolete: true [Term] id: GO:0051184 -name: cofactor transmembrane transporter activity +name: obsolete cofactor transmembrane transporter activity namespace: molecular_function -def: "Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +def: "OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a cofactor. synonym: "cofactor transporter activity" RELATED [] synonym: "vitamin or cofactor transporter activity" BROAD [] -is_a: GO:0022857 ! transmembrane transporter activity -relationship: part_of GO:0051181 ! cofactor transport +is_obsolete: true [Term] id: GO:0051185 -name: coenzyme transmembrane transporter activity +name: obsolete coenzyme transmembrane transporter activity namespace: molecular_function -def: "Enables the transfer of a coenzyme from one side of a membrane to the other. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +def: "OBSOLETE. Enables the transfer of a coenzyme from one side of a membrane to the other. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a coenzyme. synonym: "coenzyme transporter activity" RELATED [] -is_a: GO:0051184 ! cofactor transmembrane transporter activity -relationship: part_of GO:0051182 ! coenzyme transport +is_obsolete: true [Term] id: GO:0051186 -name: cofactor metabolic process +name: obsolete cofactor metabolic process namespace: biological_process -def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] -subset: goslim_chembl -subset: goslim_drosophila -subset: goslim_generic -subset: goslim_pir -subset: goslim_pombe -subset: goslim_yeast +def: "OBSOLETE. The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. synonym: "cofactor metabolism" EXACT [] -is_a: GO:0044237 ! cellular metabolic process +is_obsolete: true [Term] id: GO:0051187 -name: cofactor catabolic process +name: obsolete cofactor catabolic process namespace: biological_process -def: "The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. synonym: "cofactor breakdown" EXACT [] synonym: "cofactor catabolism" EXACT [] synonym: "cofactor degradation" EXACT [] -is_a: GO:0044248 ! cellular catabolic process -is_a: GO:0051186 ! cofactor metabolic process +is_obsolete: true [Term] id: GO:0051188 -name: cofactor biosynthetic process +name: obsolete cofactor biosynthetic process namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. synonym: "cofactor anabolism" EXACT [] synonym: "cofactor biosynthesis" EXACT [] synonym: "cofactor formation" EXACT [] synonym: "cofactor synthesis" EXACT [] -is_a: GO:0044249 ! cellular biosynthetic process -is_a: GO:0051186 ! cofactor metabolic process +is_obsolete: true [Term] id: GO:0051189 @@ -328706,7 +326567,7 @@ subset: goslim_pir synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "prosthetic group metabolism" EXACT [] -is_a: GO:0051186 ! cofactor metabolic process +is_a: GO:0008152 ! metabolic process relationship: part_of GO:0044267 ! cellular protein metabolic process [Term] @@ -328719,7 +326580,7 @@ synonym: "coenzyme and prosthetic group catabolism" BROAD [] synonym: "prosthetic group breakdown" EXACT [] synonym: "prosthetic group catabolism" EXACT [] synonym: "prosthetic group degradation" EXACT [] -is_a: GO:0051187 ! cofactor catabolic process +is_a: GO:0009056 ! catabolic process is_a: GO:0051189 ! prosthetic group metabolic process relationship: part_of GO:0044257 ! cellular protein catabolic process @@ -328734,7 +326595,7 @@ synonym: "prosthetic group anabolism" EXACT [] synonym: "prosthetic group biosynthesis" EXACT [] synonym: "prosthetic group formation" EXACT [] synonym: "prosthetic group synthesis" EXACT [] -is_a: GO:0051188 ! cofactor biosynthetic process +is_a: GO:0009058 ! biosynthetic process is_a: GO:0051189 ! prosthetic group metabolic process relationship: part_of GO:0009059 ! macromolecule biosynthetic process @@ -328743,70 +326604,61 @@ id: GO:0051192 name: prosthetic group binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai, GOC:vw] -is_a: GO:0048037 ! cofactor binding +is_a: GO:0005488 ! binding [Term] id: GO:0051193 -name: regulation of cofactor metabolic process +name: obsolete regulation of cofactor metabolic process namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. synonym: "regulation of cofactor metabolism" EXACT [] -is_a: GO:0031323 ! regulation of cellular metabolic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0051186 ! cofactor metabolic process -relationship: regulates GO:0051186 ! cofactor metabolic process +is_obsolete: true [Term] id: GO:0051194 -name: positive regulation of cofactor metabolic process +name: obsolete positive regulation of cofactor metabolic process namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. synonym: "activation of cofactor metabolic process" NARROW [] synonym: "positive regulation of cofactor metabolism" EXACT [] synonym: "stimulation of cofactor metabolic process" NARROW [] synonym: "up regulation of cofactor metabolic process" EXACT [] synonym: "up-regulation of cofactor metabolic process" EXACT [] synonym: "upregulation of cofactor metabolic process" EXACT [] -is_a: GO:0031325 ! positive regulation of cellular metabolic process -is_a: GO:0051193 ! regulation of cofactor metabolic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0051186 ! cofactor metabolic process -relationship: positively_regulates GO:0051186 ! cofactor metabolic process +is_obsolete: true [Term] id: GO:0051195 -name: negative regulation of cofactor metabolic process +name: obsolete negative regulation of cofactor metabolic process namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. synonym: "down regulation of cofactor metabolic process" EXACT [] synonym: "down-regulation of cofactor metabolic process" EXACT [] synonym: "downregulation of cofactor metabolic process" EXACT [] synonym: "inhibition of cofactor metabolic process" NARROW [] synonym: "negative regulation of cofactor metabolism" EXACT [] -is_a: GO:0031324 ! negative regulation of cellular metabolic process -is_a: GO:0051193 ! regulation of cofactor metabolic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0051186 ! cofactor metabolic process -relationship: negatively_regulates GO:0051186 ! cofactor metabolic process +is_obsolete: true [Term] id: GO:0051196 -name: regulation of coenzyme metabolic process +name: obsolete regulation of coenzyme metabolic process namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "regulation of coenzyme metabolism" EXACT [] -is_a: GO:0051193 ! regulation of cofactor metabolic process -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0006732 ! coenzyme metabolic process -relationship: regulates GO:0006732 ! coenzyme metabolic process +is_obsolete: true [Term] id: GO:0051197 -name: positive regulation of coenzyme metabolic process +name: obsolete positive regulation of coenzyme metabolic process namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. synonym: "activation of coenzyme metabolic process" NARROW [] synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] @@ -328815,17 +326667,14 @@ synonym: "stimulation of coenzyme metabolic process" NARROW [] synonym: "up regulation of coenzyme metabolic process" EXACT [] synonym: "up-regulation of coenzyme metabolic process" EXACT [] synonym: "upregulation of coenzyme metabolic process" EXACT [] -is_a: GO:0051194 ! positive regulation of cofactor metabolic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0006732 ! coenzyme metabolic process -relationship: positively_regulates GO:0006732 ! coenzyme metabolic process +is_obsolete: true [Term] id: GO:0051198 -name: negative regulation of coenzyme metabolic process +name: obsolete negative regulation of coenzyme metabolic process namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. synonym: "down regulation of coenzyme metabolic process" EXACT [] synonym: "down-regulation of coenzyme metabolic process" EXACT [] synonym: "downregulation of coenzyme metabolic process" EXACT [] @@ -328833,11 +326682,7 @@ synonym: "inhibition of coenzyme metabolic process" NARROW [] synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "negative regulation of coenzyme metabolism" EXACT [] -is_a: GO:0051195 ! negative regulation of cofactor metabolic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0006732 ! coenzyme metabolic process -relationship: negatively_regulates GO:0006732 ! coenzyme metabolic process +is_obsolete: true [Term] id: GO:0051199 @@ -328848,7 +326693,6 @@ synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [ synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "regulation of prosthetic group metabolism" EXACT [] is_a: GO:0032268 ! regulation of cellular protein metabolic process -is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051189 ! prosthetic group metabolic process relationship: regulates GO:0051189 ! prosthetic group metabolic process @@ -328867,7 +326711,6 @@ synonym: "up regulation of prosthetic group metabolic process" EXACT [] synonym: "up-regulation of prosthetic group metabolic process" EXACT [] synonym: "upregulation of prosthetic group metabolic process" EXACT [] is_a: GO:0032270 ! positive regulation of cellular protein metabolic process -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0051199 ! regulation of prosthetic group metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051189 ! prosthetic group metabolic process @@ -328886,7 +326729,6 @@ synonym: "negative regulation of coenzyme and prosthetic group metabolic process synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] synonym: "negative regulation of prosthetic group metabolism" EXACT [] is_a: GO:0032269 ! negative regulation of cellular protein metabolic process -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0051199 ! regulation of prosthetic group metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051189 ! prosthetic group metabolic process @@ -328899,7 +326741,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553] synonym: "phytochromobilin metabolism" EXACT [] is_a: GO:0033013 ! tetrapyrrole metabolic process -is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0051203 @@ -329959,7 +327800,6 @@ synonym: "NAD or NADH binding" RELATED [GOC:mah] synonym: "NAD+ or NADH binding" RELATED [] synonym: "nicotinamide adenine dinucleotide binding" EXACT [] is_a: GO:0000166 ! nucleotide binding -is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0051289 @@ -331010,7 +328850,6 @@ name: serotonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai] synonym: "5-hydroxytryptamine binding" EXACT [] -is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043169 ! cation binding is_a: GO:0043176 ! amine binding is_a: GO:0097159 ! organic cyclic compound binding @@ -331037,7 +328876,6 @@ id: GO:0051381 name: histamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] -is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043169 ! cation binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding @@ -331338,7 +329176,6 @@ synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8] synonym: "clostridiopeptidase B activity" EXACT [] synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8] synonym: "clostripain activity" EXACT [] -xref: EC:3.4.22.8 is_obsolete: true replaced_by: GO:0004197 @@ -331371,7 +329208,6 @@ synonym: "metalloproteinase-1" RELATED [EC:3.4.24.3] synonym: "microbial collagenase activity" EXACT [] synonym: "nucleolysin" RELATED [EC:3.4.24.3] synonym: "soycollagestin" RELATED [EC:3.4.24.3] -xref: EC:3.4.24.3 is_obsolete: true replaced_by: GO:0004252 @@ -331453,7 +329289,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [ISBN:0721662544, PMID:11276391] synonym: "response to cortisol stimulus" EXACT [GOC:dos] synonym: "response to hydrocortisone stimulus" EXACT [] -is_a: GO:0042493 ! response to drug is_a: GO:0051384 ! response to glucocorticoid is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone @@ -331580,7 +329415,6 @@ synonym: "corticotropin-releasing factor binding" EXACT [] synonym: "CRF binding" EXACT [GOC:bf] synonym: "CRH binding" EXACT [] is_a: GO:0017046 ! peptide hormone binding -is_a: GO:0042165 ! neurotransmitter binding [Term] id: GO:0051425 @@ -332130,7 +329964,6 @@ name: regulation of cortisol secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai] is_a: GO:2000849 ! regulation of glucocorticoid secretion -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0043400 ! cortisol secretion relationship: regulates GO:0043400 ! cortisol secretion @@ -332146,7 +329979,6 @@ synonym: "downregulation of cortisol secretion" EXACT [] synonym: "inhibition of cortisol secretion" NARROW [] is_a: GO:0051462 ! regulation of cortisol secretion is_a: GO:2000850 ! negative regulation of glucocorticoid secretion -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043400 ! cortisol secretion relationship: negatively_regulates GO:0043400 ! cortisol secretion @@ -332163,7 +329995,6 @@ synonym: "up-regulation of cortisol secretion" EXACT [] synonym: "upregulation of cortisol secretion" EXACT [] is_a: GO:0051462 ! regulation of cortisol secretion is_a: GO:2000851 ! positive regulation of glucocorticoid secretion -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043400 ! cortisol secretion relationship: positively_regulates GO:0043400 ! cortisol secretion @@ -332181,7 +330012,6 @@ synonym: "negative regulation of corticotropin-releasing factor secretion" EXACT synonym: "negative regulation of CRF secretion" EXACT [] synonym: "negative regulation of CRH secretion" EXACT [] is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion -is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:0090278 ! negative regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion @@ -332201,7 +330031,6 @@ synonym: "up regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "up-regulation of corticotropin-releasing hormone secretion" EXACT [] synonym: "upregulation of corticotropin-releasing hormone secretion" EXACT [] is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion -is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:0090277 ! positive regulation of peptide hormone secretion intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion @@ -332249,6 +330078,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai] synonym: "glucosylglycerol metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process +is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0019400 ! alditol metabolic process [Term] @@ -332260,6 +330090,7 @@ synonym: "glucosylglycerol anabolism" EXACT [] synonym: "glucosylglycerol biosynthesis" EXACT [] synonym: "glucosylglycerol formation" EXACT [] synonym: "glucosylglycerol synthesis" EXACT [] +is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0019401 ! alditol biosynthetic process is_a: GO:0051472 ! glucosylglycerol metabolic process @@ -332270,6 +330101,7 @@ namespace: molecular_function def: "Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity relationship: part_of GO:0051475 ! glucosylglycerol transport [Term] @@ -332279,6 +330111,7 @@ namespace: biological_process def: "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport +is_a: GO:1901656 ! glycoside transport [Term] id: GO:0051476 @@ -332593,6 +330426,7 @@ namespace: molecular_function def: "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667] xref: EC:3.1.1.96 xref: MetaCyc:RXN-15041 +xref: RHEA:13953 is_a: GO:0002161 ! aminoacyl-tRNA editing activity [Term] @@ -332895,7 +330729,6 @@ synonym: "Fe/S binding" EXACT [] synonym: "iron sulfur cluster binding" EXACT [] synonym: "iron sulphur cluster binding" EXACT [] synonym: "iron-sulphur cluster binding" EXACT [] -is_a: GO:0048037 ! cofactor binding is_a: GO:0051540 ! metal cluster binding [Term] @@ -333438,7 +331271,6 @@ synonym: "regulation of dopamine import involved in synaptic transmission" EXACT is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission relationship: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission @@ -333456,7 +331288,6 @@ is_a: GO:0032227 ! negative regulation of synaptic transmission, dopaminergic is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission relationship: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission @@ -333476,7 +331307,6 @@ is_a: GO:0032226 ! positive regulation of synaptic transmission, dopaminergic is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission relationship: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission @@ -333559,11 +331389,9 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:ai] synonym: "cellular response to folate" EXACT [GOC:mah] synonym: "cellular response to vitamin B9" EXACT [GOC:mah] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin -is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound [Term] @@ -333718,7 +331546,6 @@ name: histamine transport namespace: biological_process def: "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0006812 ! cation transport -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport @@ -334034,9 +331861,7 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai] synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of ion transport -is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:0051952 ! regulation of amine transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051630 ! acetylcholine uptake relationship: regulates GO:0051630 ! acetylcholine uptake @@ -334051,10 +331876,8 @@ synonym: "down-regulation of acetylcholine uptake" EXACT [] synonym: "downregulation of acetylcholine uptake" EXACT [] synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] is_a: GO:0043271 ! negative regulation of ion transport -is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051953 ! negative regulation of amine transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0051630 ! acetylcholine uptake relationship: negatively_regulates GO:0051630 ! acetylcholine uptake @@ -334071,10 +331894,8 @@ synonym: "up regulation of acetylcholine uptake" EXACT [] synonym: "up-regulation of acetylcholine uptake" EXACT [] synonym: "upregulation of acetylcholine uptake" EXACT [] is_a: GO:0043270 ! positive regulation of ion transport -is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:0051631 ! regulation of acetylcholine uptake is_a: GO:0051954 ! positive regulation of amine transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0051630 ! acetylcholine uptake relationship: positively_regulates GO:0051630 ! acetylcholine uptake @@ -334790,6 +332611,7 @@ name: proline oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [MetaCyc:RXN-821] xref: MetaCyc:RXN-821 +xref: RHEA:26124 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] @@ -335070,7 +332892,6 @@ synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter a synonym: "reduced NAD transporter activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] is_a: GO:0015215 ! nucleotide transmembrane transporter activity -is_a: GO:0051185 ! coenzyme transmembrane transporter activity relationship: part_of GO:0035352 ! NAD transmembrane transport created_by: jl creation_date: 2012-09-19T13:21:08Z @@ -335215,6 +333036,7 @@ synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphatase activity" EXACT [EC:2.7.1.78] synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] xref: EC:2.7.1.78 +xref: RHEA:54580 is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity [Term] @@ -335266,7 +333088,6 @@ name: ethylene binding namespace: molecular_function def: "Interacting selectively and non-covalently with ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai] synonym: "ethene binding" EXACT [] -is_a: GO:0042562 ! hormone binding is_a: GO:0072328 ! alkene binding [Term] @@ -335276,6 +333097,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542] synonym: "MPBQ methyltransferase activity" EXACT [] xref: MetaCyc:RXN-2542 +xref: RHEA:37979 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -335285,6 +333107,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762] synonym: "MSBQ methyltransferase activity" EXACT [] xref: MetaCyc:RXN-2762 +xref: RHEA:37999 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] @@ -335294,6 +333117,7 @@ namespace: molecular_function def: "Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence." [PMID:10743659] synonym: "RCC reductase activity" EXACT [] xref: MetaCyc:RXN-7741 +xref: RHEA:24752 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] @@ -335302,6 +333126,7 @@ name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity namespace: molecular_function def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72] xref: MetaCyc:RXN1F-72 +xref: RHEA:48884 is_a: GO:0016491 ! oxidoreductase activity [Term] @@ -335347,6 +333172,7 @@ synonym: "UDP-sugar pyrophosphorylase activity" EXACT [EC:2.7.7.64] synonym: "USP" RELATED [EC:2.7.7.64] xref: EC:2.7.7.64 xref: MetaCyc:2.7.7.64-RXN +xref: RHEA:13205 is_a: GO:0070569 ! uridylyltransferase activity [Term] @@ -335657,6 +333483,7 @@ comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reaction synonym: "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [EC:1.14.13.79] synonym: "ent-kaurenoic acid oxidase activity" EXACT [] xref: MetaCyc:1.14.13.79-RXN +xref: RHEA:19241 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -335666,6 +333493,7 @@ namespace: molecular_function def: "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160] comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. xref: MetaCyc:RXN1F-160 +xref: RHEA:22904 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -335676,6 +333504,7 @@ def: "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gib comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'. synonym: "GA12-aldehyde oxidase activity" EXACT [] xref: MetaCyc:RXN1F-161 +xref: RHEA:22700 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -336175,7 +334004,7 @@ def: "Any process in which an organism modulates the frequency, rate or extent o is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction relationship: regulates GO:0051838 ! cytolysis by host of symbiont cells @@ -336403,6 +334232,7 @@ synonym: "protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase a xref: EC:1.14.11.27 xref: MetaCyc:RXN-8660 xref: MetaCyc:RXN-8661 +xref: RHEA:42032 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0032452 ! histone demethylase activity relationship: part_of GO:0070544 ! histone H3-K36 demethylation @@ -336591,7 +334421,6 @@ namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] synonym: "killing of cells in other organism during symbiotic interaction" RELATED [GOC:tb] is_a: GO:0031640 ! killing of cells of other organism -is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0051884 @@ -337336,10 +335165,8 @@ namespace: biological_process def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0006835 ! dicarboxylic acid transport -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0015807 ! L-amino acid transport -is_a: GO:0015893 ! drug transport is_a: GO:0043090 ! amino acid import [Term] @@ -338106,6 +335933,7 @@ synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT [] xref: EC:1.1.99.39 xref: Reactome:R-HSA-880007 "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2" xref: Reactome:R-HSA-880053 "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]" +xref: RHEA:38295 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] @@ -338116,6 +335944,7 @@ def: "Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-d comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227. xref: EC:2.4.1.227 xref: MetaCyc:NACGLCTRANS-RXN +xref: RHEA:31227 is_a: GO:0008375 ! acetylglucosaminyltransferase activity created_by: ai creation_date: 2010-07-06T11:53:19Z @@ -338129,6 +335958,7 @@ comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso- subset: goslim_chembl xref: EC:2.7.8.13 xref: MetaCyc:PHOSNACMURPENTATRANS-RXN +xref: RHEA:28386 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups created_by: ai creation_date: 2010-07-06T12:10:01Z @@ -338141,6 +335971,7 @@ def: "Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic ac synonym: "ABA-GE beta-glucosidase activity" EXACT [] xref: EC:3.2.1.175 xref: MetaCyc:RXN-11469 +xref: RHEA:31347 is_a: GO:0008422 ! beta-glucosidase activity created_by: ai creation_date: 2010-07-16T02:16:59Z @@ -338186,6 +336017,7 @@ synonym: "4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxyl synonym: "OHCU decarboxylase activity" EXACT [] xref: KEGG_REACTION:R06604 xref: MetaCyc:RXN-6201 +xref: RHEA:26301 is_a: GO:0016831 ! carboxy-lyase activity created_by: ai creation_date: 2010-07-19T10:47:15Z @@ -338266,7 +336098,6 @@ is_a: GO:0044414 ! suppression of host defenses by symbiont is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response -is_a: GO:2001039 ! negative regulation of cellular response to drug relationship: negatively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway [Term] @@ -339011,7 +336842,6 @@ is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0044416 ! induction by symbiont of host defense response is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response is_a: GO:1901672 ! positive regulation of systemic acquired resistance -is_a: GO:2001040 ! positive regulation of cellular response to drug relationship: positively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway [Term] @@ -341144,7 +338974,7 @@ synonym: "stimulation by organism of programmed cell death in other organism dur synonym: "upregulation by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "upregulation by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT [] is_a: GO:0043068 ! positive regulation of programmed cell death -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process is_a: GO:0051712 ! positive regulation of killing of cells of other organism is_a: GO:0052248 ! modulation of programmed cell death in other organism involved in symbiotic interaction relationship: positively_regulates GO:0051883 ! killing of cells in other organism involved in symbiotic interaction @@ -341525,7 +339355,7 @@ synonym: "modulation by organism of entry into other organism during symbiotic i synonym: "modulation by symbiont of entry into host" RELATED [] synonym: "regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] synonym: "regulation by organism of entry into other organism involved in symbiotic interaction" RELATED [] -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044409 ! entry into host relationship: regulates GO:0044409 ! entry into host @@ -341609,6 +339439,7 @@ xref: EC:2.5.1.75 xref: MetaCyc:RXN0-6274 xref: Reactome:R-HSA-6784462 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs" xref: Reactome:R-HSA-6787567 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser)" +xref: RHEA:26482 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA creation_date: 2010-07-23T03:07:33Z @@ -343318,6 +341149,7 @@ synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene xref: EC:4.2.3.22 xref: KEGG_REACTION:R07648 xref: MetaCyc:RXN-8562 +xref: RHEA:12016 is_a: GO:0010334 ! sesquiterpene synthase activity created_by: ai creation_date: 2010-08-09T01:39:02Z @@ -343329,6 +341161,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate." [MetaCyc:RXN-8574] synonym: "(E,E)-alpha-farnesene synthase activity" EXACT [MetaCyc:RXN-8574] xref: MetaCyc:RXN-8574 +xref: RHEA:27421 is_a: GO:0010334 ! sesquiterpene synthase activity created_by: ai creation_date: 2010-08-09T01:39:42Z @@ -343481,6 +341314,7 @@ def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycer comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. xref: EC:1.1.5.3 xref: MetaCyc:GLYC3PDEHYDROG-RXN +xref: RHEA:28751 is_a: GO:0052590 ! sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity [Term] @@ -343510,6 +341344,7 @@ def: "Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + xref: EC:1.4.3.21 xref: KEGG_REACTION:R02529 xref: MetaCyc:AMACETOXID-RXN +xref: RHEA:28186 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] @@ -343581,6 +341416,7 @@ synonym: "trimethylenediamine oxidase activity" EXACT [CHEBI:15725] xref: EC:1.4.3.22 xref: KEGG_REACTION:R03139 xref: MetaCyc:RXN-6381 +xref: RHEA:30895 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] @@ -343624,6 +341460,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol." [MetaCyc:RXN-2561, PMID:12213958] xref: KEGG_REACTION:R07503 xref: MetaCyc:RXN-2561 +xref: RHEA:37987 is_a: GO:0009975 ! cyclase activity [Term] @@ -343633,6 +341470,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol." [MetaCyc:RXN-2543, PMID:12213958] xref: KEGG_REACTION:R07502 xref: MetaCyc:RXN-2543 +xref: RHEA:37983 is_a: GO:0009975 ! cyclase activity [Term] @@ -343700,6 +341538,7 @@ synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12 synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99 xref: MetaCyc:RXN-8026 +xref: RHEA:30327 is_a: GO:0004497 ! monooxygenase activity [Term] @@ -343712,6 +341551,7 @@ synonym: "beta-carotene hydroxylase activity" BROAD [] synonym: "carotene beta-ring hydroxylase activity" BROAD [] xref: EC:1.14.99 xref: MetaCyc:RXN-8025 +xref: RHEA:30323 is_a: GO:0004497 ! monooxygenase activity [Term] @@ -343745,6 +341585,7 @@ namespace: molecular_function def: "Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate." [MetaCyc:RXN0-6444, PMID:20369853, PMID:20400551] synonym: "pyrimidine oxygenase activity" BROAD [MetaCyc:RXN0-6444] xref: MetaCyc:RXN0-6444 +xref: RHEA:31587 is_a: GO:0016491 ! oxidoreductase activity creation_date: 2010-08-26T10:11:11Z @@ -343765,6 +341606,7 @@ namespace: molecular_function def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al." [MetaCyc:RXN-5242] xref: EC:1.14.14.86 xref: MetaCyc:RXN-5242 +xref: RHEA:21304 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -343774,6 +341616,7 @@ namespace: molecular_function def: "Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate." [MetaCyc:RXN-7580] xref: EC:1.14.14.86 xref: MetaCyc:RXN-7580 +xref: RHEA:10928 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -343803,6 +341646,7 @@ namespace: molecular_function def: "Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2." [MetaCyc:RXN-8646] xref: EC:1.17.99.4 xref: MetaCyc:RXN-8646 +xref: RHEA:13469 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] @@ -343911,8 +341755,8 @@ is_a: GO:0016881 ! acid-amino acid ligase activity id: GO:0052629 name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity namespace: molecular_function -def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [MetaCyc:RXN-10958, PMID:19901554] -xref: EC:3.1.3 +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [PMID:19901554, RHEA:39019] +xref: EC:3.1.3.95 xref: MetaCyc:RXN-10958 xref: Reactome:R-HSA-1676065 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane" xref: Reactome:R-HSA-1676105 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane" @@ -343920,6 +341764,7 @@ xref: Reactome:R-HSA-1676203 "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs xref: Reactome:R-HSA-6809320 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane" xref: Reactome:R-HSA-6809778 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1" xref: Reactome:R-HSA-6809944 "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane" +xref: RHEA:39019 is_a: GO:0106018 ! phosphatidylinositol-3,5-bisphosphate phosphatase activity [Term] @@ -343947,6 +341792,7 @@ name: sphingolipid delta-8 desaturase activity namespace: molecular_function def: "Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8)." [PMID:17600137, PMID:9786850] xref: MetaCyc:RXN-7798 +xref: RHEA:46268 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] @@ -344013,7 +341859,7 @@ is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0052638 name: indole-3-butyrate beta-glucosyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP." [MetaCyc:RXN-11655] +def: "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP." [MetaCyc:RXN-11655, RHEA:62708] synonym: "IBA-Glc synthetase activity" EXACT [] synonym: "IBA-glucose synthase activity" EXACT [] synonym: "IBAGlu synthase activity" EXACT [] @@ -344026,32 +341872,35 @@ synonym: "UDPG-indol-3-ylbutyryl glucosyl transferase activity" EXACT [] synonym: "UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity" EXACT [] synonym: "uridine diphosphoglucose-indolebutyrate glucosyltransferase activity" EXACT [] xref: MetaCyc:RXN-11655 +xref: RHEA:62708 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052639 name: salicylic acid glucosyltransferase (ester-forming) activity namespace: molecular_function -def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP." [MetaCyc:RXN-11659] +def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP." [MetaCyc:RXN-11659, RHEA:62316] synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11659] synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] synonym: "UDP:glucose:SA glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] synonym: "UDP:glucose:salicylate glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] synonym: "UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] xref: MetaCyc:RXN-11659 +xref: RHEA:62316 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0052640 name: salicylic acid glucosyltransferase (glucoside-forming) activity namespace: molecular_function -def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP." [MetaCyc:RXN-11658] +def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP." [MetaCyc:RXN-11658, RHEA:62312] synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11658] synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] synonym: "UDP:glucose:SA glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] synonym: "UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] synonym: "UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] xref: MetaCyc:RXN-11658 +xref: RHEA:62312 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] @@ -344152,7 +342001,6 @@ synonym: "coenzyme F420 metabolism" EXACT [CHEBI:16848] synonym: "coenzyme gamma-F420-2 metabolism" EXACT [] synonym: "F420-2 metabolic process" EXACT [CHEBI:16848] synonym: "F420-2 metabolism" EXACT [CHEBI:16848] -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0052648 ! ribitol phosphate metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process @@ -344221,7 +342069,6 @@ synonym: "cdiGMP metabolism" EXACT [] synonym: "cyclic diguanylate metabolic process" EXACT [] synonym: "cyclic diguanylate metabolism" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0052652 ! cyclic purine nucleotide metabolic process created_by: ai creation_date: 2010-09-23T11:16:56Z @@ -344248,6 +342095,7 @@ synonym: "L-valine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG_REACTION:R01214 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN +xref: RHEA:24813 is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity [Term] @@ -344260,6 +342108,7 @@ synonym: "L-isoleucine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG_REACTION:R02199 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN +xref: RHEA:24801 is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity [Term] @@ -344282,6 +342131,7 @@ synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8] xref: EC:2.4.2.8 xref: KEGG_REACTION:R01229 xref: MetaCyc:GUANPRIBOSYLTRAN-RXN +xref: RHEA:25424 is_a: GO:0106130 ! purine phosphoribosyltransferase activity [Term] @@ -344377,14 +342227,13 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0052663 name: antheraxanthin epoxidase activity namespace: molecular_function -def: "Catalysis of the reaction: antheraxanthin + NAD(P)H + H+ + O2 = all-trans-violaxanthin + NAD(P)+ + H2O." [MetaCyc:RXN-7979] +def: "Catalysis of the reaction: antheraxanthin + NAD(P)H + H+ + O2 = all-trans-violaxanthin + NAD(P)+ + H2O." [MetaCyc:RXN-7979, RHEA:14937] synonym: "antheraxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90] xref: EC:1.14.13.90 xref: KEGG_REACTION:R06947 "antheraxanthin,NADH:oxygen oxidoreductase activity" xref: KEGG_REACTION:R07200 "antheraxanthin,NADPH:oxygen oxidoreductase activity" xref: MetaCyc:RXN-7979 xref: RHEA:14937 -xref: RHEA:14944 "antheraxanthin,NADH:oxygen oxidoreductase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -344473,6 +342322,7 @@ def: "Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-tr synonym: "CTP:2-trans,-6-trans-farnesol phosphotransferase activity" EXACT [] xref: EC:2.7.1.216 xref: MetaCyc:RXN-11625 +xref: RHEA:51680 is_a: GO:0052668 ! farnesol kinase activity created_by: ai creation_date: 2011-04-11T01:32:05Z @@ -344742,6 +342592,7 @@ xref: MetaCyc:CARBOXYLESTERASE-RXN xref: Reactome:R-HSA-5693691 "CES1 trimer.CES2 hydrolyse COCN to BEG" xref: Reactome:R-HSA-8937442 "CES3 hydrolyses CHEST to CHOL and LCFA(-)" xref: Reactome:R-HSA-9619024 "CES1trimer hydrolyses ACEI pro-drugs to ACEIs" +xref: RHEA:21164 xref: UM-BBD_reactionID:r1025 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds @@ -344749,14 +342600,12 @@ is_a: GO:0016788 ! hydrolase activity, acting on ester bonds id: GO:0052690 name: trichloro-p-hydroquinone reductive dehalogenase activity namespace: molecular_function -def: "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0031, UM-BBD_reactionID:r0315] +def: "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl." [PMID:1459949, RHEA:56832, UM-BBD_reactionID:r0315] synonym: "pentaerythritol tetranitrate reductase activity" RELATED [UM-BBD_enzymeID:e0028] synonym: "tetrachlorohydroquinone reductive dehalogenase activity" RELATED [UM-BBD_enzymeID:e0251] synonym: "trichlorohydroquinone reductive dehalogenase activity" EXACT [] synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028] -xref: EC:1.6.99.1 -xref: EC:1.8.99 -xref: UM-BBD_reactionID:r0031 +xref: RHEA:56832 xref: UM-BBD_reactionID:r0315 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors @@ -344804,6 +342653,7 @@ name: jasmonoyl-isoleucine-12-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O." [MetaCyc:RXN-12421, PMID:21576464] xref: MetaCyc:RXN-12421 +xref: RHEA:54808 is_a: GO:0004497 ! monooxygenase activity [Term] @@ -344959,14 +342809,14 @@ creation_date: 2011-08-01T03:49:39Z [Term] id: GO:0052704 -name: ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine +name: ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide namespace: biological_process -def: "The pathway resulting in the formation of ergothioneine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). N-alpha,N-alpha,N-alpha-trimethyl-L-histidine is modified by the ligation of gamma-glutamyl-cysteine and oxygen; this intermediate undergoes further modification by the removal of glutamate to produce hercynylcysteine sulfoxide. Finally, a beta-lyase acts on this compound, removing pyruvate, ammonia and oxygen to produce ergothioneine." [DOI:10.1021/ja101721e, EC:2.1.1.44, PMID:4276459, PMID:5484456, Wikipedia:Ergothioneine] -is_a: GO:0006548 ! histidine catabolic process +def: "The pathway resulting in the formation of ergothioneine from histidine via a set of steps in which gamma-glutamyl-hercynylcysteine sulfoxide is formed as an intermediate." [PMID:4276459, PMID:5484456] +synonym: "ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine" BROAD [] +xref: Wikipedia:Ergothioneine is_a: GO:0052699 ! ergothioneine biosynthetic process -is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process relationship: has_part GO:0052707 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine -relationship: has_part GO:0052711 ! ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/11163 xsd:anyURI creation_date: 2011-08-05T11:31:52Z [Term] @@ -345078,17 +342928,18 @@ creation_date: 2011-08-05T02:22:54Z [Term] id: GO:0052711 -name: ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine +name: obsolete ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine namespace: biological_process -def: "The pathway resulting in the formation of ergothioneine from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [KEGG_REACTION:R04878] +def: "OBSOLETE. The pathway resulting in the formation of ergothioneine from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [KEGG_REACTION:R04878] +comment: The reason for obsoletion is that this term does not provide a useful distinction from its parent, GO:0052704 (because that trimethyl-His yada is present in both pathways) synonym: "ergothioneine biosynthesis from hercynine" EXACT [] synonym: "ergothioneine biosynthesis from histidine betaine" EXACT [] synonym: "hercynine catabolism to ergothioneine" EXACT [] synonym: "histidine betaine catabolism to ergothioneine" EXACT [] synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism to ergothioneine" EXACT [] xref: KEGG_REACTION:R04878 -is_a: GO:0052699 ! ergothioneine biosynthetic process -is_a: GO:0052710 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/11163 xsd:anyURI +is_obsolete: true creation_date: 2011-08-05T04:06:16Z [Term] @@ -345138,6 +342989,7 @@ synonym: "p-diphenol:oxygen oxidoreductase activity" EXACT [] xref: EC:1.10.3.2 xref: KEGG_REACTION:R00083 xref: MetaCyc:LACCASE-RXN +xref: RHEA:11276 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor created_by: ai creation_date: 2011-08-11T03:18:19Z @@ -345206,6 +343058,7 @@ name: fatty acid in-chain hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O." [MetaCyc:RXN-12186] xref: MetaCyc:RXN-12186 +xref: RHEA:45084 is_a: GO:0004497 ! monooxygenase activity created_by: ai creation_date: 2011-08-15T01:41:07Z @@ -345249,6 +343102,7 @@ xref: EC:2.7.1.159 xref: MetaCyc:2.7.1.133-RXN xref: Reactome:R-HSA-1855197 "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol" xref: Reactome:R-HSA-2267372 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4" +xref: RHEA:20940 is_a: GO:0051766 ! inositol trisphosphate kinase activity created_by: ai creation_date: 2011-08-16T12:42:59Z @@ -345270,6 +343124,7 @@ xref: KEGG_REACTION:R03428 xref: MetaCyc:2.7.1.139-RXN xref: Reactome:R-HSA-1855172 "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol" xref: Reactome:R-HSA-994140 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4" +xref: RHEA:13253 is_a: GO:0051766 ! inositol trisphosphate kinase activity created_by: ai creation_date: 2011-08-16T12:43:11Z @@ -345284,6 +343139,7 @@ synonym: "CCS" RELATED [EC:5.3.99.8] synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8] xref: EC:5.3.99.8 xref: MetaCyc:RXN-7947 +xref: RHEA:17373 is_a: GO:0016860 ! intramolecular oxidoreductase activity created_by: ai creation_date: 2011-08-16T03:09:21Z @@ -345299,6 +343155,7 @@ synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8] synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" EXACT [EC:5.3.99.8] xref: EC:5.3.99.8 xref: MetaCyc:RXN-7946 +xref: RHEA:21752 is_a: GO:0016860 ! intramolecular oxidoreductase activity created_by: ai creation_date: 2011-08-16T03:09:26Z @@ -345552,6 +343409,7 @@ synonym: "sinapyl-alcohol:NADP+ oxidoreductase activity" EXACT systematic_synony xref: EC:1.1.1.195 xref: KEGG_REACTION:R03918 xref: MetaCyc:RXN-1125 +xref: RHEA:45704 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor creation_date: 2011-09-21T12:42:06Z @@ -345595,6 +343453,7 @@ synonym: "versatile peroxidase activity" BROAD [EC:1.11.1.16] xref: EC:1.11.1.16 xref: KEGG_REACTION:R07612 xref: MetaCyc:RXN-8666 +xref: RHEA:22396 is_a: GO:0004601 ! peroxidase activity created_by: ai creation_date: 2011-09-21T02:33:34Z @@ -346436,7 +344295,6 @@ id: GO:0052825 name: inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] -xref: EC:3.1.3 xref: Reactome:R-HSA-1855219 "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol" is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity creation_date: 2011-11-29T09:49:22Z @@ -346468,6 +344326,7 @@ name: inositol-3,4-bisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate." [GOC:mah] xref: Reactome:R-HSA-1855202 "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol" +xref: RHEA:43388 is_a: GO:0016312 ! inositol bisphosphate phosphatase activity created_by: ai creation_date: 2011-11-29T09:57:00Z @@ -346477,7 +344336,6 @@ id: GO:0052829 name: inositol-1,3,4-trisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [GOC:ai] -xref: EC:3.1.3 xref: Reactome:R-HSA-1855232 "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol" is_a: GO:0046030 ! inositol trisphosphate phosphatase activity created_by: ai @@ -346488,7 +344346,6 @@ id: GO:0052830 name: inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate." [GOC:ai] -xref: EC:3.1.3 xref: Reactome:R-HSA-1855171 "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol" is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity created_by: ai @@ -346499,7 +344356,6 @@ id: GO:0052831 name: inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate." [GOC:ai] -xref: EC:3.1.3 xref: Reactome:R-HSA-1855159 "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol" is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity created_by: ai @@ -346513,6 +344369,7 @@ def: "Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + xref: EC:3.1.3.25 xref: MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN xref: Reactome:R-HSA-1855210 "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol" +xref: RHEA:30739 is_a: GO:0052834 ! inositol monophosphate phosphatase activity created_by: ai creation_date: 2011-11-29T11:00:09Z @@ -346528,6 +344385,7 @@ synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [] xref: EC:3.1.3.25 xref: MetaCyc:RXN-10952 xref: Reactome:R-HSA-1855211 "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol" +xref: RHEA:30735 is_a: GO:0052834 ! inositol monophosphate phosphatase activity created_by: ai creation_date: 2011-11-29T11:02:15Z @@ -346548,6 +344406,7 @@ synonym: "myo-inositol-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] xref: EC:3.1.3.25 xref: MetaCyc:RXN-10949 +xref: RHEA:24056 is_a: GO:0052745 ! inositol phosphate phosphatase activity created_by: ai creation_date: 2011-11-29T11:15:58Z @@ -346658,6 +344517,7 @@ xref: EC:3.6.1.52 xref: KEGG_REACTION:R05779 xref: Reactome:R-HSA-1855198 "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol" xref: Reactome:R-HSA-2023971 "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol" +xref: RHEA:22384 is_a: GO:0016462 ! pyrophosphatase activity created_by: ai creation_date: 2011-11-29T04:14:22Z @@ -346978,15 +344838,14 @@ creation_date: 2011-12-13T01:20:17Z id: GO:0052867 name: phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity namespace: molecular_function -def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.-] -synonym: "phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.-] -synonym: "phosphatidylinositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.-] -synonym: "phosphatidylinositol-trisphosphatase activity" BROAD [EC:3.1.3.-] -synonym: "PtdIns(1,4,5)P(3) phosphatase activity" BROAD [EC:3.1.3.-] -synonym: "PtdIns(1,4,5)P3 phosphatase activity" BROAD [EC:3.1.3.-] -synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.-] -synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.-] -xref: EC:3.1.3 +def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate." [GOC:curators] +synonym: "phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity" BROAD [] +synonym: "phosphatidylinositol 1,4,5-trisphosphate phosphatase activity" BROAD [] +synonym: "phosphatidylinositol-trisphosphatase activity" BROAD [] +synonym: "PtdIns(1,4,5)P(3) phosphatase activity" BROAD [] +synonym: "PtdIns(1,4,5)P3 phosphatase activity" BROAD [] +synonym: "triphosphoinositide phosphatase activity" BROAD [] +synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [] is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity creation_date: 2012-01-11T12:07:50Z @@ -347350,6 +345209,7 @@ synonym: "oxynitrilase activity" BROAD [EC:4.1.2.47] xref: EC:4.1.2.47 xref: KEGG_REACTION:R09359 xref: MetaCyc:RXN-11732 +xref: RHEA:54660 is_a: GO:0016832 ! aldehyde-lyase activity [Term] @@ -347360,6 +345220,7 @@ def: "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetami synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14] xref: EC:1.5.3.14 xref: MetaCyc:RXN-10465 +xref: RHEA:25996 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] @@ -347520,6 +345381,7 @@ synonym: "tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity" EXACT [EC:2.1.1.22 synonym: "tRNA(m(1)G(9)/m(1)A(9))Mtase activity" EXACT [EC:2.1.1.221] xref: EC:2.1.1.221 xref: MetaCyc:RXN-12459 +xref: RHEA:43156 is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity [Term] @@ -347532,6 +345394,7 @@ synonym: "tRNA (m(1)G(37)) methyltransferase activity" EXACT [EC:2.1.1.228] synonym: "tRNA-(N(1)G37) methyltransferase activity" EXACT [EC:2.1.1.228] xref: EC:2.1.1.228 xref: MetaCyc:RXN-12458 +xref: RHEA:36899 is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity [Term] @@ -347544,6 +345407,7 @@ synonym: "rRNA large subunit methyltransferase F activity" RELATED [EC:2.1.1.181 xref: EC:2.1.1.181 xref: KEGG_REACTION:R07232 xref: MetaCyc:RXN-11596 +xref: RHEA:16497 is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity [Term] @@ -347554,6 +345418,7 @@ def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adeni synonym: "S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity" EXACT [EC:2.1.1.182] xref: EC:2.1.1.182 xref: MetaCyc:RXN-11633 +xref: RHEA:19609 is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity [Term] @@ -347564,6 +345429,7 @@ def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adeni synonym: "M(6)(2)A dimethylase activity" BROAD [EC:2.1.1.183] xref: EC:2.1.1.183 xref: MetaCyc:RXN-11634 +xref: RHEA:42780 is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity [Term] @@ -347576,6 +345442,7 @@ synonym: "rRNA methyltransferase ermC' activity" RELATED [EC:2.1.1.184] synonym: "rRNA:m(6)A methyltransferase ermC' activity" RELATED [EC:2.1.1.184] xref: EC:2.1.1.184 xref: MetaCyc:RXN-11597 +xref: RHEA:42784 is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity [Term] @@ -347615,6 +345482,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S xref: EC:2.1.1.171 xref: KEGG_REACTION:R07234 xref: MetaCyc:RXN0-6515 +xref: RHEA:23548 is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity [Term] @@ -347626,6 +345494,7 @@ synonym: "M(2)G1207 methyltransferase activity" EXACT [EC:2.1.1.172] xref: EC:2.1.1.172 xref: KEGG_REACTION:R07234 xref: MetaCyc:RXN-11576 +xref: RHEA:42736 is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity [Term] @@ -347636,6 +345505,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23 xref: EC:2.1.1.173 xref: KEGG_REACTION:R07234 xref: MetaCyc:RXN-11574 +xref: RHEA:42740 is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity [Term] @@ -347646,6 +345516,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23 xref: EC:2.1.1.174 xref: KEGG_REACTION:R07234 xref: MetaCyc:RXN-11635 +xref: RHEA:42744 is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity [Term] @@ -347702,6 +345573,7 @@ def: "Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + aceton xref: EC:4.1.2.46 xref: KEGG_REACTION:R01553 xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN +xref: RHEA:11932 is_a: GO:0052919 ! aliphatic (R)-hydroxynitrile lyase activity [Term] @@ -347816,6 +345688,7 @@ synonym: "methanol dehydrogenase activity" BROAD [EC:1.1.2.7] xref: EC:1.1.2.7 xref: KEGG_REACTION:R01146 xref: MetaCyc:RXN-2861 +xref: RHEA:51008 is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] @@ -347848,6 +345721,7 @@ def: "Catalysis of the reaction: primary alcohol + 2 cytochrome c(L) = 2 reduced synonym: "alcohol:cytochrome c(L) oxidoreductase activity" EXACT systematic_synonym [EC:1.1.2.7] xref: EC:1.1.2.7 xref: MetaCyc:RXN-11332 +xref: RHEA:51004 is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] @@ -349063,7 +346937,6 @@ namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd] synonym: "pyrrolidine-2-carboxylic acid biosynthetic process" BROAD [] is_a: GO:0006561 ! proline biosynthetic process -is_a: GO:0017144 ! drug metabolic process created_by: jid creation_date: 2009-10-22T01:59:56Z @@ -349909,7 +347782,7 @@ is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0060087 -name: relaxation of vascular smooth muscle +name: relaxation of vascular associated smooth muscle namespace: biological_process alt_id: GO:1905657 alt_id: GO:1905658 @@ -349918,6 +347791,7 @@ def: "A negative regulation of smooth muscle contraction resulting in relaxation synonym: "negative regulation of relaxation of vascular smooth muscle" RELATED [] synonym: "positive regulation of relaxation of vascular smooth muscle" RELATED [] synonym: "regulation of relaxation of vascular smooth muscle" RELATED [] +synonym: "relaxation of vascular smooth muscle" EXACT [] synonym: "vascular smooth muscle relaxation" EXACT [] is_a: GO:0044557 ! relaxation of smooth muscle is_a: GO:0045986 ! negative regulation of smooth muscle contraction @@ -349953,7 +347827,8 @@ subset: goslim_pir synonym: "binding, bridging" EXACT [] synonym: "protein complex scaffold activity" RELATED [] synonym: "protein-containing complex scaffold activity" RELATED [] -is_a: GO:0005488 ! binding +is_a: GO:0003674 ! molecular_function +relationship: has_part GO:0005488 ! binding [Term] id: GO:0060091 @@ -350547,7 +348422,7 @@ id: GO:0060147 name: regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] -is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0060968 ! regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016441 ! posttranscriptional gene silencing relationship: regulates GO:0016441 ! posttranscriptional gene silencing @@ -350557,7 +348432,7 @@ id: GO:0060148 name: positive regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] -is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0060147 ! regulation of posttranscriptional gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016441 ! posttranscriptional gene silencing @@ -350568,8 +348443,8 @@ id: GO:0060149 name: negative regulation of posttranscriptional gene silencing namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] -is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0060147 ! regulation of posttranscriptional gene silencing +is_a: GO:0060969 ! negative regulation of gene silencing intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016441 ! posttranscriptional gene silencing relationship: negatively_regulates GO:0016441 ! posttranscriptional gene silencing @@ -350668,7 +348543,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction -is_a: GO:2001038 ! regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0007212 ! dopamine receptor signaling pathway relationship: regulates GO:0007212 ! dopamine receptor signaling pathway @@ -350681,7 +348555,6 @@ def: "Any process that stops, prevents, or reduces the frequency, rate or extent synonym: "negative regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway -is_a: GO:2001039 ! negative regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway relationship: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway @@ -350694,7 +348567,6 @@ def: "Any process that activates or increases the frequency, rate or extent of t synonym: "positive regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway -is_a: GO:2001040 ! positive regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0007212 ! dopamine receptor signaling pathway relationship: positively_regulates GO:0007212 ! dopamine receptor signaling pathway @@ -352481,7 +350353,7 @@ relationship: positively_regulates GO:0034341 ! response to interferon-gamma id: GO:0060333 name: interferon-gamma-mediated signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:dph, GOC:signaling, PR:000000017] +def: "A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:dph, GOC:signaling] synonym: "gamma-interferon-mediated signaling pathway" EXACT [GOC:dph] synonym: "immune interferon signaling pathway" EXACT [GOC:dph] synonym: "interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] @@ -352544,7 +350416,7 @@ relationship: negatively_regulates GO:0060333 ! interferon-gamma-mediated signal id: GO:0060337 name: type I interferon signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph, GOC:signaling, PR:000025848] +def: "A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph, GOC:signaling] synonym: "type I interferon-activated signaling pathway" EXACT [GOC:signaling] synonym: "type I interferon-mediated signaling pathway" RELATED [GOC:signaling] synonym: "type I interferon-mediated signalling pathway" EXACT [GOC:mah] @@ -352768,7 +350640,9 @@ relationship: negatively_regulates GO:1903801 ! L-leucine import across plasma m id: GO:0060359 name: response to ammonium ion namespace: biological_process -def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:dph, GOC:tb] +alt_id: GO:1903717 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] +synonym: "response to ammonia" EXACT [] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound @@ -353262,7 +351136,6 @@ name: regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] is_a: GO:0001505 ! regulation of neurotransmitter levels -is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0008150 ! biological_process @@ -353274,7 +351147,6 @@ id: GO:0060409 name: positive regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] -is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0033240 ! positive regulation of cellular amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0008150 ! biological_process @@ -353286,7 +351158,6 @@ id: GO:0060410 name: negative regulation of acetylcholine metabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] -is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0033239 ! negative regulation of cellular amine metabolic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0008150 ! biological_process @@ -353400,6 +351271,7 @@ id: GO:0060422 name: peptidyl-dipeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain." [GOC:dph, GOC:tb] +xref: Wikipedia:ACE_inhibitor is_a: GO:0030414 ! peptidase inhibitor activity [Term] @@ -354775,7 +352647,6 @@ name: regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032768 ! regulation of monooxygenase activity -is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0060556 ! regulation of vitamin D biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -354790,7 +352661,6 @@ name: positive regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032770 ! positive regulation of monooxygenase activity -is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0060557 ! positive regulation of vitamin D biosynthetic process is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process @@ -359334,7 +357204,7 @@ namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart] synonym: "heart vascular smooth muscle cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation -is_a: GO:0035886 ! vascular smooth muscle cell differentiation +is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation relationship: part_of GO:0060976 ! coronary vasculature development created_by: dph creation_date: 2009-09-29T02:56:08Z @@ -359346,7 +357216,7 @@ namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state." [GOC:mtg_heart] synonym: "heart vascular smooth muscle cell development" EXACT [GOC:mtg_heart] is_a: GO:0055006 ! cardiac cell development -is_a: GO:0097084 ! vascular smooth muscle cell development +is_a: GO:0097084 ! vascular associated smooth muscle cell development relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation created_by: dph creation_date: 2009-09-29T03:00:24Z @@ -359358,7 +357228,7 @@ namespace: biological_process def: "The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart] synonym: "heart vascular smooth muscle cell fate commitment" EXACT [GOC:mtg_heart] is_a: GO:0060911 ! cardiac cell fate commitment -is_a: GO:0097081 ! vascular smooth muscle cell fate commitment +is_a: GO:0097081 ! vascular associated smooth muscle cell fate commitment relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation created_by: dph creation_date: 2009-09-29T03:02:45Z @@ -364155,8 +362025,8 @@ id: GO:0061370 name: testosterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5." [GOC:dph, GOC:yaf] +is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process -is_a: GO:0120178 ! steroid hormone biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process created_by: dph creation_date: 2010-10-27T02:50:48Z @@ -364378,21 +362248,23 @@ creation_date: 2011-07-14T10:25:55Z [Term] id: GO:0061392 -name: regulation of transcription from RNA polymerase II promoter in response to osmotic stress +name: obsolete regulation of transcription from RNA polymerase II promoter in response to osmotic stress namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577] -is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress -is_a: GO:0071470 ! cellular response to osmotic stress +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577] +comment: This term was obsoleted because it represents a GO-CAM model. +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI +is_obsolete: true created_by: dph creation_date: 2011-12-13T08:52:04Z [Term] id: GO:0061393 -name: positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress namespace: biological_process -def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577] -is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress -is_a: GO:0061392 ! regulation of transcription from RNA polymerase II promoter in response to osmotic stress +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577] +comment: This term was obsoleted because it represents a GO-CAM model. +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI +is_obsolete: true created_by: dph creation_date: 2011-12-13T08:58:20Z @@ -364469,11 +362341,12 @@ creation_date: 2012-01-10T09:36:02Z [Term] id: GO:0061401 -name: positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment namespace: biological_process -def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph] -is_a: GO:0061393 ! positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress -is_a: GO:0071476 ! cellular hypotonic response +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph] +comment: This term was obsoleted because it represents a GO-CAM model. +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI +is_obsolete: true created_by: dph creation_date: 2012-01-10T09:43:08Z @@ -364500,11 +362373,12 @@ creation_date: 2012-01-10T03:15:30Z [Term] id: GO:0061404 -name: positive regulation of transcription from RNA polymerase II promoter in response to increased salt +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to increased salt namespace: biological_process -def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph] -is_a: GO:0036251 ! positive regulation of transcription from RNA polymerase II promoter in response to salt stress -is_a: GO:0071475 ! cellular hyperosmotic salinity response +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph] +comment: This term was obsoleted because it represents a GO-CAM model. +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI +is_obsolete: true created_by: dph creation_date: 2012-01-10T03:20:40Z @@ -364620,11 +362494,12 @@ creation_date: 2012-01-23T11:33:08Z [Term] id: GO:0061416 -name: regulation of transcription from RNA polymerase II promoter in response to salt stress +name: obsolete regulation of transcription from RNA polymerase II promoter in response to salt stress namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph, PMID:18667581] -is_a: GO:0061392 ! regulation of transcription from RNA polymerase II promoter in response to osmotic stress -is_a: GO:0071472 ! cellular response to salt stress +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph, PMID:18667581] +comment: This term was obsoleted because it represents a GO-CAM model. +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI +is_obsolete: true created_by: dph creation_date: 2012-01-23T12:56:36Z @@ -365340,7 +363215,7 @@ creation_date: 2012-12-06T15:23:15Z id: GO:0061493 name: central plaque of mitotic spindle pole body namespace: cellular_component -def: "One of three laminate structures that form the mitotic spindle pole body; the central plaque is embedded in the nuclear envelope." [GOC:dph] +def: "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body." [GOC:dph] is_a: GO:0005823 ! central plaque of spindle pole body relationship: part_of GO:0044732 ! mitotic spindle pole body created_by: dph @@ -365429,6 +363304,7 @@ name: cyclic-GMP-AMP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP." [GOC:dph, PMID:23258413] xref: Reactome:R-HSA-3244614 "cGAS produces cyclic GMP-AMP" +xref: RHEA:35647 is_a: GO:0016779 ! nucleotidyltransferase activity created_by: dph creation_date: 2013-01-04T07:17:57Z @@ -365698,7 +363574,6 @@ def: "The regulated release of aspartate by a cell." [GOC:dph] is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032940 ! secretion by cell -is_a: GO:0046717 ! acid secretion created_by: dph creation_date: 2013-06-21T15:45:37Z @@ -365783,7 +363658,6 @@ namespace: biological_process def: "The controlled release of glycine by a cell." [GOC:dph] is_a: GO:0015816 ! glycine transport is_a: GO:0032940 ! secretion by cell -is_a: GO:0046717 ! acid secretion created_by: dph creation_date: 2013-06-21T16:18:23Z @@ -365813,7 +363687,6 @@ id: GO:0061539 name: octopamine secretion namespace: biological_process def: "The controlled release of octopamine by a cell." [GOC:dph] -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015695 ! organic cation transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0032940 ! secretion by cell @@ -365880,7 +363753,6 @@ id: GO:0061545 name: tyramine secretion namespace: biological_process def: "The regulated release of a tyramine by a cell." [GOC:dph] -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0061531 ! primary amine secretion @@ -366254,6 +364126,7 @@ namespace: molecular_function def: "Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone." [GOC:dph] synonym: "autoinducer-1 synthase" RELATED [GOC:dph] xref: EC:2.3.1.184 +xref: RHEA:10096 is_a: GO:0016410 ! N-acyltransferase activity created_by: dph creation_date: 2013-11-15T19:48:23Z @@ -366403,6 +364276,7 @@ namespace: molecular_function def: "Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP." [PMID:24463506] xref: EC:2.7.1.184 xref: MetaCyc:RXN-15297 +xref: RHEA:40443 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor created_by: dph creation_date: 2014-02-10T09:59:26Z @@ -366423,6 +364297,7 @@ namespace: molecular_function def: "Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+." [EC:1.1.1.373, GOC:dph, PMID:24463506] xref: EC:1.1.1.373 xref: MetaCyc:RXN-15299 +xref: RHEA:40511 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor created_by: dph creation_date: 2014-02-10T10:09:43Z @@ -366455,6 +364330,7 @@ namespace: molecular_function def: "Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP." [EC:2.10.1.1, GOC:dph] xref: EC:2.10.1.1 xref: Reactome:R-HSA-947531 "Molybdenum ion transfer onto molybdopterin" +xref: RHEA:35047 is_a: GO:0016740 ! transferase activity created_by: dph creation_date: 2014-02-10T14:30:31Z @@ -366465,6 +364341,7 @@ name: molybdenum cofactor cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor." [EC:2.7.7.76, GOC:dph] xref: EC:2.7.7.76 +xref: RHEA:31335 is_a: GO:0070567 ! cytidylyltransferase activity created_by: dph creation_date: 2014-02-10T14:46:38Z @@ -366475,6 +364352,7 @@ name: molybdenum cofactor guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor." [EC:2.7.7.77, GOC:dph] xref: EC:2.7.7.77 +xref: RHEA:34243 is_a: GO:0070568 ! guanylyltransferase activity created_by: dph creation_date: 2014-02-10T14:54:36Z @@ -366485,6 +364363,7 @@ name: molybdopterin-synthase sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase." [EC:2.8.1.11, GOC:dph, PMID:18154309, PMID:22370186] xref: EC:2.8.1.11 +xref: RHEA:48612 is_a: GO:0016783 ! sulfurtransferase activity created_by: dph creation_date: 2014-02-11T11:56:16Z @@ -366495,6 +364374,7 @@ name: molybdopterin-synthase adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP." [EC:2.7.7.80, GOC:dph, PMID:18154309, PMID:22370186] xref: EC:2.7.7.80 +xref: RHEA:43616 is_a: GO:0070566 ! adenylyltransferase activity created_by: dph creation_date: 2014-02-11T12:01:32Z @@ -366886,6 +364766,7 @@ xref: Reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL" xref: Reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation" xref: Reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216" xref: Reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4" +xref: Reactome:R-HSA-9686969 "APC/C:Cdh1 polyubiquitinates SKP2" xref: Reactome:R-HSA-990526 "Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1" is_a: GO:0004842 ! ubiquitin-protein transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity @@ -367478,12 +365359,16 @@ creation_date: 2015-03-04T16:00:21Z [Term] id: GO:0061686 -name: hercynylcysteine sulfoxide synthase +name: hercynylcysteine sulfoxide synthase activity namespace: molecular_function -def: "Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine + O2 <=> hercynylcysteine sulfoxide + H2O." [GOC:dph, PMID:28577] +def: "Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 <=> hercynylcysteine sulfoxide + H2O." [GOC:dph, PMID:24828577, PMID:4276459, RHEA:42704] synonym: "hercynylcysteine S-oxide synthase" EXACT [GOC:dph] +synonym: "hercynylcysteine sulfoxide synthase" EXACT [] +xref: EC:1.14.99.51 +xref: RHEA:42704 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -relationship: part_of GO:0052699 ! ergothioneine biosynthetic process +relationship: part_of GO:0140479 ! ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/11163 xsd:anyURI created_by: dph creation_date: 2015-03-06T15:08:51Z @@ -367708,6 +365593,7 @@ namespace: molecular_function def: "Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+." [GOC:dph, PMID:15509579] xref: MetaCyc:RXN-16821 xref: Reactome:R-HSA-6787447 "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA" +xref: RHEA:47040 is_a: GO:0016783 ! sulfurtransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA created_by: dph @@ -368681,6 +366567,7 @@ namespace: molecular_function def: "Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate." [GOC:dph, GOC:ik, PMID:25896388] xref: EC:4.1.99.22 xref: MetaCyc:RXN-8340 +xref: RHEA:49576 is_a: GO:0016830 ! carbon-carbon lyase activity created_by: dph creation_date: 2016-10-06T14:26:11Z @@ -368692,6 +366579,7 @@ namespace: molecular_function def: "Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate." [GOC:dph, GOC:ik, PMID:25896388] xref: EC:4.6.1.17 xref: MetaCyc:RXN-17809 +xref: RHEA:49580 is_a: GO:0016849 ! phosphorus-oxygen lyase activity created_by: dph creation_date: 2016-10-06T14:36:56Z @@ -368820,6 +366708,7 @@ name: NAD glycohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528] xref: EC:3.2.2.5 +xref: Reactome:R-HSA-9637699 "CpnT hydrolyses NAD+" is_a: GO:0003953 ! NAD+ nucleosidase activity created_by: dph creation_date: 2016-11-11T13:18:54Z @@ -369950,6 +367839,7 @@ name: glutathione specific gamma-glutamylcyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine." [PMID:23070364, PMID:27913623] xref: EC:4.3.2.7 +xref: RHEA:47724 is_a: GO:0016842 ! amidine-lyase activity created_by: dph creation_date: 2017-08-29T14:55:30Z @@ -369960,6 +367850,7 @@ name: gamma-glutamylaminecyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline." [PMID:20110353, PMID:6107907] xref: EC:4.3.2.8 +xref: RHEA:16961 is_a: GO:0016842 ! amidine-lyase activity created_by: dph creation_date: 2017-08-29T14:57:39Z @@ -370256,8 +368147,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an (R)-carnitine stimulus." [PMID:28102299] synonym: "response to L-carnitine" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound -is_a: GO:0033273 ! response to vitamin -is_a: GO:0042493 ! response to drug created_by: dph creation_date: 2018-01-19T13:31:39Z @@ -370570,6 +368459,7 @@ name: beta-ketodecanoyl-[acyl-carrier-protein] synthase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2." [EC:2.3.1.207, PMID:22753057] xref: MetaCyc:RXN-13613 +xref: RHEA:42264 is_a: GO:0016415 ! octanoyltransferase activity created_by: dph creation_date: 2018-02-15T22:29:03Z @@ -371429,7 +369319,7 @@ id: GO:0062086 name: regulation of vein smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203] -is_a: GO:0003056 ! regulation of vascular smooth muscle contraction +is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014826 ! vein smooth muscle contraction relationship: regulates GO:0014826 ! vein smooth muscle contraction @@ -371442,7 +369332,7 @@ name: positive regulation of vein smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203] is_a: GO:0062086 ! regulation of vein smooth muscle contraction -is_a: GO:1904695 ! positive regulation of vascular smooth muscle contraction +is_a: GO:1904695 ! positive regulation of vascular associated smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014826 ! vein smooth muscle contraction relationship: positively_regulates GO:0014826 ! vein smooth muscle contraction @@ -371455,7 +369345,7 @@ name: negative regulation of vein smooth muscle contraction namespace: biological_process def: "Any process that decreases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203] is_a: GO:0062086 ! regulation of vein smooth muscle contraction -is_a: GO:1904694 ! negative regulation of vascular smooth muscle contraction +is_a: GO:1904694 ! negative regulation of vascular associated smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014826 ! vein smooth muscle contraction relationship: negatively_regulates GO:0014826 ! vein smooth muscle contraction @@ -371469,7 +369359,6 @@ namespace: biological_process def: "Any process that modulates the rate, frequency or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process -is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process @@ -371484,7 +369373,6 @@ name: positive regulation of taurine biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process -is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process @@ -371999,8 +369887,8 @@ id: GO:0062142 name: L-beta-ethynylserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-beta-ethynylserine. L-beta-ethynylserine is an antibiotic produced by Streptomyces bacteria." [PMID:3082841, PMID:30867596] -is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0043453 ! alkyne biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process created_by: dph creation_date: 2019-09-02T16:39:59Z @@ -372009,8 +369897,8 @@ id: GO:0062143 name: L-propargylglycine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-propargylglycine (Pra). L-propargylglycine is an antibiotic produced by Streptomyces bacteria." [PMID:30867596] -is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0043453 ! alkyne biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process created_by: dph creation_date: 2019-09-02T16:45:12Z @@ -372198,7 +370086,6 @@ def: "Any process that modulates the frequency, rate or extent of a pyocyanine b synonym: "regulation of pyocyanin biosynthetic process" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process -is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0106220 ! pyocyanine biosynthetic process relationship: regulates GO:0106220 ! pyocyanine biosynthetic process @@ -372214,7 +370101,6 @@ synonym: "positive regulation of pyocyanin biosynthetic process" EXACT [] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:0062161 ! regulation of pyocyanine biosynthetic process -is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0106220 ! pyocyanine biosynthetic process relationship: positively_regulates GO:0106220 ! pyocyanine biosynthetic process @@ -372358,7 +370244,6 @@ synonym: "allotetrahydroprogesterone metabolic process" EXACT [] synonym: "allotetrahydroprogesterone metabolism" EXACT [] synonym: "brexanolone metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: dph @@ -372405,7 +370290,6 @@ synonym: "brexanolone catabolism" EXACT [] synonym: "brexanolone degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0042182 ! ketone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0062173 ! brexanolone metabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process created_by: dph @@ -372935,7 +370819,7 @@ namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of platelet activating factor, 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine." [PMID:16371369] synonym: "2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine catabolic process" EXACT [] synonym: "PAF catabolic process" RELATED [] -is_a: GO:0042737 ! drug catabolic process +is_a: GO:0044269 ! glycerol ether catabolic process is_a: GO:0046469 ! platelet activating factor metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process @@ -372989,6 +370873,9 @@ id: GO:0062239 name: heterochromatin-nuclear membrane anchor activity namespace: molecular_function def: "Interacting selectively and non-covalently with heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization." [PMID:31635174] +synonym: "heterochromatin-nuclear membrane tether activity" EXACT [] +synonym: "nuclear membrane-heterochromatin anchor activity" EXACT [] +synonym: "nuclear membrane-heterochromatin tether activity" EXACT [] is_a: GO:0043495 ! protein-membrane adaptor activity created_by: dph creation_date: 2020-04-20T18:20:36Z @@ -372998,6 +370885,9 @@ id: GO:0062240 name: euchromatin-nuclear membrane anchor activity namespace: molecular_function def: "Interacting selectively and non-covalently with euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization." [PMID:31635174] +synonym: "euchromatin-nuclear membrane tether activity" EXACT [] +synonym: "nuclear membrane-euchromatin anchor activity" EXACT [] +synonym: "nuclear membrane-euchromatin tether activity" EXACT [] is_a: GO:0043495 ! protein-membrane adaptor activity created_by: dph creation_date: 2020-04-20T18:22:35Z @@ -373080,6 +370970,17 @@ relationship: part_of GO:0009507 ! chloroplast created_by: dph creation_date: 2020-05-01T12:10:16Z +[Term] +id: GO:0062248 +name: cleistothecium formation +namespace: biological_process +def: "The process of producing a cleistothecium, a closed sexual fruiting body that contains ascospores in linear asci. Cleistothecia are present in some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [PMID:20348388, PMID:28889020, PMID:30410052] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0070791 ! cleistothecium development +created_by: dph +creation_date: 2020-05-08T16:14:06Z + [Term] id: GO:0065001 name: specification of axis polarity @@ -373184,21 +371085,21 @@ id: GO:0070001 name: aspartic-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] -is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides +is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070002 name: glutamic-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] -is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides +is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070003 name: threonine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] -is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides +is_a: GO:0008233 ! peptidase activity [Term] id: GO:0070004 @@ -373250,24 +371151,6 @@ def: "Catalysis of the hydrolysis of a peptide bond not more than three residues is_a: GO:0004177 ! aminopeptidase activity is_a: GO:0070008 ! serine-type exopeptidase activity -[Term] -id: GO:0070010 -name: peptidase activity, acting on D-amino acid peptides -namespace: molecular_function -def: "Catalysis of the hydrolysis of peptide bonds formed between D-amino acids." [GOC:mah] -is_a: GO:0008233 ! peptidase activity - -[Term] -id: GO:0070011 -name: peptidase activity, acting on L-amino acid peptides -namespace: molecular_function -def: "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids." [GOC:mah] -xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA" -xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs" -xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB" -xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)" -is_a: GO:0008233 ! peptidase activity - [Term] id: GO:0070012 name: oligopeptidase activity @@ -373407,8 +371290,6 @@ name: carbon monoxide binding namespace: molecular_function def: "Interacting selectively and non-covalently with carbon monoxide (CO)." [GOC:ecd] synonym: "CO binding" EXACT [] -is_a: GO:0008144 ! drug binding -is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043169 ! cation binding [Term] @@ -374493,7 +372374,7 @@ name: SUMO-specific endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah] xref: Reactome:R-HSA-2990840 "SENP1,2,5 proteolytically process SUMO1" -xref: Reactome:R-HSA-2990842 "SEN1,2,5 proteolytically process SUMO2" +xref: Reactome:R-HSA-2990842 "SENP1,2,5 proteolytically process SUMO2" xref: Reactome:R-HSA-2993763 "SENP1,2,5 proteolytically process SUMO3" is_a: GO:0016929 ! SUMO-specific protease activity is_a: GO:0070137 ! ubiquitin-like protein-specific endopeptidase activity @@ -374906,7 +372787,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid." [CHEBI:16523, GOC:jsg, GOC:mah] synonym: "D-serine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] @@ -375377,6 +373257,7 @@ synonym: "sulfide-quinone reductase activity" EXACT [MetaCyc:MONOMER-12314] synonym: "sulphide:quinone oxidoreductase activity" EXACT [GOC:mah] xref: MetaCyc:R17-RXN xref: Reactome:R-HSA-1614665 "SQR oxidizes sulfide to bound persulfide" +xref: RHEA:30239 is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor [Term] @@ -375388,6 +373269,7 @@ synonym: "flavocytochrome c sulfide dehydrogenase activity" EXACT [MetaCyc:RXN-8 synonym: "sulphide dehydrogenase activity" EXACT [GOC:mah] xref: EC:1.8.2 xref: MetaCyc:RXN-8156 +xref: RHEA:30223 is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor [Term] @@ -375796,6 +373678,7 @@ def: "Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pr synonym: "pristanate:CoA ligase (AMP-forming)" EXACT [GOC:mah] synonym: "pristanoyl-CoA ligase activity" EXACT [GOC:mah] xref: Reactome:R-HSA-389632 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate" +xref: RHEA:47264 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity @@ -376031,7 +373914,7 @@ is_a: GO:0019329 ! ammonia oxidation id: GO:0070276 name: halogen metabolic process namespace: biological_process -def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [CHEBI:22473, GOC:mah] +def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [GOC:mah] synonym: "halogen metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process @@ -376058,7 +373941,6 @@ id: GO:0070279 name: vitamin B6 binding namespace: molecular_function def: "Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah] -is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding @@ -376069,7 +373951,6 @@ name: pyridoxal binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah] is_a: GO:0043169 ! cation binding -is_a: GO:0048037 ! cofactor binding is_a: GO:0070279 ! vitamin B6 binding [Term] @@ -376085,7 +373966,6 @@ id: GO:0070282 name: pyridoxine binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16709, GOC:mah] -is_a: GO:0048037 ! cofactor binding is_a: GO:0070279 ! vitamin B6 binding [Term] @@ -376272,10 +374152,7 @@ name: cellular response to hydrogen peroxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [CHEBI:16240, GOC:mah] is_a: GO:0034614 ! cellular response to reactive oxygen species -is_a: GO:0035690 ! cellular response to drug is_a: GO:0042542 ! response to hydrogen peroxide -is_a: GO:0071236 ! cellular response to antibiotic -is_a: GO:0097237 ! cellular response to toxic substance [Term] id: GO:0070302 @@ -376589,6 +374466,7 @@ def: "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. synonym: "estrogen synthetase activity" NARROW [] xref: EC:1.14.14.1 xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN +xref: RHEA:17149 xref: UM-BBD_enzymeID:e0551 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen @@ -377899,7 +375777,6 @@ synonym: "regulation of heme anabolism" EXACT [GOC:mah] synonym: "regulation of heme biosynthesis" EXACT [GOC:mah] synonym: "regulation of heme formation" EXACT [GOC:mah] synonym: "regulation of heme synthesis" EXACT [GOC:mah] -is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006783 ! heme biosynthetic process @@ -377919,7 +375796,6 @@ synonym: "negative regulation of heme anabolism" EXACT [GOC:mah] synonym: "negative regulation of heme biosynthesis" EXACT [GOC:mah] synonym: "negative regulation of heme formation" EXACT [GOC:mah] synonym: "negative regulation of heme synthesis" EXACT [GOC:mah] -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0070453 ! regulation of heme biosynthetic process is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -377941,7 +375817,6 @@ synonym: "stimulation of heme biosynthetic process" NARROW [GOC:mah] synonym: "up regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "up-regulation of heme biosynthetic process" EXACT [GOC:mah] synonym: "upregulation of heme biosynthetic process" EXACT [GOC:mah] -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0070453 ! regulation of heme biosynthetic process is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -378238,7 +376113,6 @@ name: dehydro-D-arabinono-1,4-lactone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [GOC:cjk, GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone metabolism" EXACT [GOC:mah] -is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901334 ! lactone metabolic process [Term] @@ -378250,7 +376124,6 @@ synonym: "dehydro-D-arabinono-1,4-lactone anabolism" EXACT [GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone biosynthesis" EXACT [GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone formation" EXACT [GOC:mah] synonym: "dehydro-D-arabinono-1,4-lactone synthesis" EXACT [GOC:mah] -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0070484 ! dehydro-D-arabinono-1,4-lactone metabolic process is_a: GO:1901336 ! lactone biosynthetic process @@ -378643,6 +376516,7 @@ synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146] xref: EC:1.1.1.146 xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN +xref: RHEA:11388 is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [Term] @@ -378780,7 +376654,6 @@ id: GO:0070542 name: response to fatty acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:lp] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound @@ -379700,7 +377573,6 @@ is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009229 ! thiamine diphosphate biosynthetic process relationship: regulates GO:0009229 ! thiamine diphosphate biosynthetic process @@ -379726,7 +377598,6 @@ is_a: GO:0045936 ! negative regulation of phosphate metabolic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0070616 ! regulation of thiamine diphosphate biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0009229 ! thiamine diphosphate biosynthetic process @@ -379850,6 +377721,7 @@ synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] xref: EC:4.3.2.2 xref: KEGG_REACTION:R04559 xref: MetaCyc:AICARSYN-RXN +xref: RHEA:23920 is_a: GO:0016842 ! amidine-lyase activity created_by: mah creation_date: 2009-05-01T04:13:49Z @@ -379909,10 +377781,6 @@ namespace: biological_process alt_id: GO:0071790 alt_id: GO:1990944 def: "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah] -synonym: "establishment and maintenance of spindle pole body localization" EXACT [GOC:mah] -synonym: "establishment of spindle pole body localisation in nuclear envelope" NARROW [GOC:mah] -synonym: "establishment of spindle pole body localization in nuclear envelope" NARROW [] -synonym: "establishment of spindle pole body localization to nuclear envelope" NARROW [] synonym: "maintenance of spindle pole body localization" NARROW [] synonym: "spindle pole body localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization @@ -379999,7 +377867,6 @@ def: "The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9 synonym: "calciferol metabolic process" EXACT [CHEBI:28934] synonym: "ergocalciferol metabolic process" EXACT [CHEBI:28934] synonym: "vitamin D2 metabolism" EXACT [GOC:mah] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0042359 ! vitamin D metabolic process created_by: mah creation_date: 2009-05-08T02:11:35Z @@ -380013,7 +377880,6 @@ synonym: "calciol metabolic process" EXACT [CHEBI:28940] synonym: "cholecalciferol metabolic process" EXACT [CHEBI:28940] synonym: "vitamin D3 metabolism" EXACT [GOC:mah] is_a: GO:0042359 ! vitamin D metabolic process -is_a: GO:0042445 ! hormone metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process created_by: mah creation_date: 2009-05-08T02:24:24Z @@ -380562,7 +378428,6 @@ synonym: "threonine catabolic process to propionate" BROAD [GOC:bf] xref: MetaCyc:PWY-5437 is_a: GO:0006567 ! threonine catabolic process is_a: GO:0019541 ! propionate metabolic process -is_a: GO:0042737 ! drug catabolic process created_by: mah creation_date: 2009-06-03T01:36:54Z @@ -380578,7 +378443,6 @@ synonym: "threonine catabolic process to acetyl-CoA" BROAD [GOC:bf] xref: MetaCyc:PWY-5436 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0006567 ! threonine catabolic process -is_a: GO:0042737 ! drug catabolic process created_by: mah creation_date: 2009-06-03T01:40:22Z @@ -381211,138 +379075,64 @@ is_a: GO:0005126 ! cytokine receptor binding created_by: mah creation_date: 2009-06-23T01:21:54Z -[Term] -id: GO:0070749 -name: interleukin-35 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] -synonym: "IL-35 biosynthesis" EXACT [GOC:mah] -synonym: "IL-35 biosynthetic process" EXACT [GOC:add] -synonym: "interleukin-35 anabolism" EXACT [GOC:mah] -synonym: "interleukin-35 biosynthesis" EXACT [GOC:mah] -synonym: "interleukin-35 formation" EXACT [GOC:mah] -synonym: "interleukin-35 synthesis" EXACT [GOC:mah] -is_a: GO:0042089 ! cytokine biosynthetic process -relationship: part_of GO:0070753 ! interleukin-35 production -created_by: mah -creation_date: 2009-06-23T01:25:11Z - -[Term] -id: GO:0070750 -name: regulation of interleukin-35 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] -synonym: "regulation of IL-35 biosynthesis" EXACT [GOC:mah] -synonym: "regulation of IL-35 biosynthetic process" EXACT [GOC:add] -synonym: "regulation of interleukin-35 anabolism" EXACT [GOC:mah] -synonym: "regulation of interleukin-35 biosynthesis" EXACT [GOC:mah] -synonym: "regulation of interleukin-35 formation" EXACT [GOC:mah] -synonym: "regulation of interleukin-35 synthesis" EXACT [GOC:mah] -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -is_a: GO:0070754 ! regulation of interleukin-35 production -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0070749 ! interleukin-35 biosynthetic process -relationship: regulates GO:0070749 ! interleukin-35 biosynthetic process -created_by: mah -creation_date: 2009-06-23T01:29:17Z - -[Term] -id: GO:0070751 -name: negative regulation of interleukin-35 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] -synonym: "down regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] -synonym: "down-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] -synonym: "downregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] -synonym: "inhibition of interleukin-35 biosynthetic process" NARROW [GOC:mah] -synonym: "negative regulation of IL-35 biosynthesis" EXACT [GOC:mah] -synonym: "negative regulation of IL-35 biosynthetic process" EXACT [GOC:add] -synonym: "negative regulation of interleukin-35 anabolism" EXACT [GOC:mah] -synonym: "negative regulation of interleukin-35 biosynthesis" EXACT [GOC:mah] -synonym: "negative regulation of interleukin-35 formation" EXACT [GOC:mah] -synonym: "negative regulation of interleukin-35 synthesis" EXACT [GOC:mah] -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process -is_a: GO:0070755 ! negative regulation of interleukin-35 production -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process -relationship: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process -created_by: mah -creation_date: 2009-06-23T01:34:54Z - -[Term] -id: GO:0070752 -name: positive regulation of interleukin-35 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add] -synonym: "activation of interleukin-35 biosynthetic process" NARROW [GOC:mah] -synonym: "positive regulation of IL-35 biosynthesis" EXACT [GOC:mah] -synonym: "positive regulation of IL-35 biosynthetic process" EXACT [GOC:add] -synonym: "positive regulation of interleukin-35 anabolism" EXACT [GOC:mah] -synonym: "positive regulation of interleukin-35 biosynthesis" EXACT [GOC:mah] -synonym: "positive regulation of interleukin-35 formation" EXACT [GOC:mah] -synonym: "positive regulation of interleukin-35 synthesis" EXACT [GOC:mah] -synonym: "stimulation of interleukin-35 biosynthetic process" NARROW [GOC:mah] -synonym: "up regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] -synonym: "up-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] -synonym: "upregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah] -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process -is_a: GO:0070756 ! positive regulation of interleukin-35 production -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process -relationship: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process -created_by: mah -creation_date: 2009-06-23T01:39:45Z - [Term] id: GO:0070753 name: interleukin-35 production namespace: biological_process +alt_id: GO:0070749 +alt_id: GO:0072626 def: "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-35 production" EXACT [GOC:add] +synonym: "interleukin-35 biosynthetic process" NARROW [] +synonym: "interleukin-35 secretion" NARROW [] is_a: GO:0001816 ! cytokine production created_by: mah -creation_date: 2009-06-23T01:42:04Z +creation_date: 2009-06-23T01:25:11Z [Term] id: GO:0070754 name: regulation of interleukin-35 production namespace: biological_process +alt_id: GO:0070750 def: "Any process that modulates the frequency, rate, or extent of interleukin-35 production." [GOC:mah] synonym: "regulation of IL-35 production" EXACT [GOC:add] +synonym: "regulation of interleukin-35 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070753 ! interleukin-35 production relationship: regulates GO:0070753 ! interleukin-35 production created_by: mah -creation_date: 2009-06-23T01:44:37Z +creation_date: 2009-06-23T01:29:17Z [Term] id: GO:0070755 name: negative regulation of interleukin-35 production namespace: biological_process +alt_id: GO:0070751 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production." [GOC:mah] synonym: "down regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "down-regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "downregulation of interleukin-35 production" EXACT [GOC:mah] synonym: "inhibition of interleukin-35 production" NARROW [GOC:mah] synonym: "negative regulation of IL-35 production" EXACT [GOC:add] +synonym: "negative regulation of interleukin-35 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0070754 ! regulation of interleukin-35 production intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070753 ! interleukin-35 production relationship: negatively_regulates GO:0070753 ! interleukin-35 production created_by: mah -creation_date: 2009-06-23T01:48:25Z +creation_date: 2009-06-23T01:34:54Z [Term] id: GO:0070756 name: positive regulation of interleukin-35 production namespace: biological_process +alt_id: GO:0070752 def: "Any process that activates or increases the frequency, rate, or extent of interleukin-35 production." [GOC:mah] synonym: "activation of interleukin-35 production" NARROW [GOC:mah] synonym: "positive regulation of IL-35 production" EXACT [GOC:add] +synonym: "positive regulation of interleukin-35 biosynthetic process" NARROW [] synonym: "stimulation of interleukin-35 production" NARROW [GOC:mah] synonym: "up regulation of interleukin-35 production" EXACT [GOC:mah] synonym: "up-regulation of interleukin-35 production" EXACT [GOC:mah] @@ -381353,7 +379143,7 @@ intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070753 ! interleukin-35 production relationship: positively_regulates GO:0070753 ! interleukin-35 production created_by: mah -creation_date: 2009-06-23T01:52:31Z +creation_date: 2009-06-23T01:39:45Z [Term] id: GO:0070757 @@ -381597,7 +379387,6 @@ namespace: biological_process alt_id: GO:0089712 def: "The directed movement of L-aspartate across a membrane." [PMID:21307582] synonym: "L-aspartate transport" BROAD [] -is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: mah @@ -381626,6 +379415,7 @@ synonym: "dihydrosphingosine-1-phosphate phosphohydrolase activity" EXACT [GOC:m synonym: "sphinganine-1-phosphate phosphatase activity" EXACT [GOC:mah] xref: MetaCyc:RXN3DJ-25 xref: Reactome:R-HSA-428664 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate" +xref: RHEA:27514 is_a: GO:0016791 ! phosphatase activity created_by: mah creation_date: 2009-07-02T02:13:49Z @@ -381639,11 +379429,9 @@ synonym: "response to Bios IIB" EXACT [GOC:sl] synonym: "response to coenzyme R" EXACT [GOC:sl] synonym: "response to vitamin B7" EXACT [GOC:sl] synonym: "response to vitamin H" EXACT [GOC:sl] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin -is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2009-07-02T02:34:43Z @@ -382098,8 +379886,6 @@ synonym: "hydrogen sulfide metabolism" EXACT [GOC:mah] synonym: "hydrogen sulphide metabolic process" EXACT [GOC:mah] synonym: "hydrogen sulphide metabolism" EXACT [GOC:mah] is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0009404 ! toxin metabolic process -is_a: GO:0017144 ! drug metabolic process created_by: mah creation_date: 2009-07-09T10:37:32Z @@ -382114,7 +379900,6 @@ synonym: "hydrogen sulfide formation" EXACT [GOC:mah] synonym: "hydrogen sulfide synthesis" EXACT [GOC:mah] synonym: "hydrogen sulphide biosynthesis" EXACT [GOC:mah] synonym: "hydrogen sulphide biosynthetic process" EXACT [GOC:mah] -is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0070813 ! hydrogen sulfide metabolic process created_by: mah @@ -383007,6 +380792,7 @@ name: sodium-dependent L-ascorbate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)." [GOC:mah, GOC:yaf, PMID:18094143] is_a: GO:0008520 ! L-ascorbate:sodium symporter activity +is_a: GO:0015229 ! L-ascorbic acid transmembrane transporter activity created_by: mah creation_date: 2009-09-01T02:25:22Z @@ -383198,8 +380984,6 @@ synonym: "transepithelial L-ascorbate transport" EXACT [GOC:mah] synonym: "transepithelial vitamin C transport" EXACT [GOC:mah] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0046942 ! carboxylic acid transport -is_a: GO:0051180 ! vitamin transport -is_a: GO:0051182 ! coenzyme transport is_a: GO:0070633 ! transepithelial transport created_by: mah creation_date: 2009-09-03T02:21:25Z @@ -383237,7 +381021,6 @@ namespace: molecular_function def: "Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)." [GOC:dh] synonym: "histidine-histamine antiporter activity" EXACT [GOC:mah] synonym: "histidine/histamine antiporter activity" EXACT [GOC:mah] -is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity is_a: GO:1901474 ! azole transmembrane transporter activity @@ -383251,8 +381034,8 @@ namespace: molecular_function def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh] synonym: "tyrosine-tyramine antiporter activity" EXACT [GOC:mah] synonym: "tyrosine/tyramine antiporter activity" EXACT [GOC:mah] -is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity is_a: GO:0008504 ! monoamine transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity @@ -383459,7 +381242,6 @@ def: "Any process that modulates the activity of an ATP:ADP antiporter." [GOC:BH is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:1903959 ! regulation of anion transmembrane transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005471 ! ATP:ADP antiporter activity relationship: regulates GO:0005471 ! ATP:ADP antiporter activity @@ -383479,7 +381261,6 @@ is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transpo is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:0070926 ! regulation of ATP:ADP antiporter activity is_a: GO:1903960 ! negative regulation of anion transmembrane transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005471 ! ATP:ADP antiporter activity relationship: negatively_regulates GO:0005471 ! ATP:ADP antiporter activity @@ -383727,7 +381508,7 @@ def: "Any process that modulates the rate, frequency or extent of neutrophil med is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0031347 ! regulation of defense response is_a: GO:0032101 ! regulation of response to external stimulus -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process is_a: GO:0051709 ! regulation of killing of cells of other organism is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity intersection_of: GO:0008150 ! biological_process @@ -384030,7 +381811,6 @@ name: coenzyme F420 binding namespace: molecular_function def: "Interacting selectively and non-covalently with F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:dh] is_a: GO:0031406 ! carboxylic acid binding -is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:0097367 ! carbohydrate derivative binding is_a: GO:1901363 ! heterocyclic compound binding @@ -384043,7 +381823,6 @@ name: pyrroloquinoline quinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases." [GOC:dh] synonym: "PQQ binding" EXACT [GOC:dh] -is_a: GO:0019842 ! vitamin binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0048038 ! quinone binding is_a: GO:0097159 ! organic cyclic compound binding @@ -384051,17 +381830,6 @@ is_a: GO:1901363 ! heterocyclic compound binding created_by: mah creation_date: 2009-10-02T11:39:13Z -[Term] -id: GO:0070970 -name: interleukin-2 secretion -namespace: biological_process -def: "The regulated release of interleukin-2 from a cell." [GOC:mah, PMID:16930574] -synonym: "IL-2 secretion" EXACT [GOC:mah] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032623 ! interleukin-2 production -created_by: mah -creation_date: 2009-10-02T12:03:07Z - [Term] id: GO:0070971 name: endoplasmic reticulum exit site @@ -384164,7 +381932,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of biphenyl synonym: "biphenyl breakdown" EXACT [GOC:mah] synonym: "biphenyl catabolism" EXACT [GOC:mah] synonym: "biphenyl degradation" EXACT [GOC:mah] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018879 ! biphenyl metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process @@ -384193,7 +381960,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [GOC:mah] synonym: "L-asparagine metabolism" EXACT [GOC:mah] is_a: GO:0006528 ! asparagine metabolic process -is_a: GO:0017144 ! drug metabolic process created_by: mah creation_date: 2009-10-27T01:03:46Z @@ -386202,6 +383968,7 @@ name: cyanophycin synthetase activity (L-aspartate-adding) namespace: molecular_function def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp." [EC:6.3.2.29] xref: EC:6.3.2.29 +xref: RHEA:13277 is_a: GO:0043860 ! cyanophycin synthetase activity created_by: mah creation_date: 2009-11-17T05:18:17Z @@ -386212,6 +383979,7 @@ name: cyanophycin synthetase activity (L-arginine-adding) namespace: molecular_function def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1." [EC:6.3.2.30] xref: EC:6.3.2.30 +xref: RHEA:23888 is_a: GO:0043860 ! cyanophycin synthetase activity created_by: mah creation_date: 2009-11-17T05:19:54Z @@ -386802,7 +384570,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:mah] is_a: GO:0009737 ! response to abscisic acid is_a: GO:0032870 ! cellular response to hormone stimulus -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:0097306 ! cellular response to alcohol created_by: mah @@ -386919,7 +384686,6 @@ name: cellular response to muramyl dipeptide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:mah] is_a: GO:0032495 ! response to muramyl dipeptide -is_a: GO:0035690 ! cellular response to drug is_a: GO:1901653 ! cellular response to peptide created_by: mah creation_date: 2009-12-03T01:41:23Z @@ -386993,9 +384759,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:mah] synonym: "response to folate" EXACT [GOC:mah] synonym: "response to vitamin B9" EXACT [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0051593 ! response to folic acid -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound @@ -387084,10 +384848,8 @@ id: GO:0071239 name: cellular response to streptomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0046679 ! response to streptomycin is_a: GO:0071236 ! cellular response to antibiotic -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah creation_date: 2009-12-03T02:25:59Z @@ -387116,7 +384878,9 @@ creation_date: 2009-12-03T02:35:49Z id: GO:0071242 name: cellular response to ammonium ion namespace: biological_process -def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:mah] +alt_id: GO:1903718 +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] +synonym: "cellular response to ammonia" EXACT [] is_a: GO:0060359 ! response to ammonium ion is_a: GO:1901699 ! cellular response to nitrogen compound created_by: mah @@ -387139,7 +384903,6 @@ name: cellular response to carbon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah] is_a: GO:0010037 ! response to carbon dioxide -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -387151,9 +384914,7 @@ name: cellular response to carbon monoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:mah] is_a: GO:0034465 ! response to carbon monoxide -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071241 ! cellular response to inorganic substance -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah creation_date: 2009-12-03T02:44:43Z @@ -387164,7 +384925,6 @@ name: cellular response to chlorate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:mah] is_a: GO:0010157 ! response to chlorate -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -387199,7 +384959,6 @@ name: cellular response to nitrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah] is_a: GO:0010167 ! response to nitrate -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902170 ! cellular response to reactive nitrogen species @@ -387211,7 +384970,6 @@ id: GO:0071250 name: cellular response to nitrite namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:mah] -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0080033 ! response to nitrite is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -387400,7 +385158,6 @@ synonym: "L-methionine biosynthesis" EXACT [GOC:mah] synonym: "L-methionine formation" EXACT [GOC:mah] synonym: "L-methionine synthesis" EXACT [GOC:mah] is_a: GO:0009086 ! methionine biosynthetic process -is_a: GO:0017144 ! drug metabolic process created_by: mah creation_date: 2009-12-09T04:28:15Z @@ -387491,8 +385248,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [GOC:mah] synonym: "morphine metabolism" EXACT [GOC:mah] xref: Wikipedia:Morphine -is_a: GO:0006805 ! xenobiotic metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0033076 ! isoquinoline alkaloid metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: mah @@ -387507,8 +385262,6 @@ synonym: "morphine breakdown" EXACT [GOC:mah] synonym: "morphine catabolism" EXACT [GOC:mah] synonym: "morphine degradation" EXACT [GOC:mah] xref: UniPathway:Q02198 -is_a: GO:0042178 ! xenobiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0071272 ! morphine metabolic process is_a: GO:0071274 ! isoquinoline alkaloid catabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process @@ -387767,9 +385520,7 @@ synonym: "cellular response to Bios IIB" EXACT [GOC:sl] synonym: "cellular response to coenzyme R" EXACT [GOC:sl] synonym: "cellular response to vitamin B7" EXACT [GOC:sl] synonym: "cellular response to vitamin H" EXACT [GOC:sl] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0070781 ! response to biotin -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound @@ -387784,7 +385535,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:mah] synonym: "cellular response to vitamin B12" EXACT [GOC:mah] is_a: GO:0033590 ! response to cobalamin -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound @@ -387800,7 +385550,6 @@ synonym: "cellular response to ascorbic acid" BROAD [GOC:mah] synonym: "cellular response to L-ascorbate" EXACT [GOC:mah] synonym: "cellular response to vitamin C" EXACT [GOC:mah] is_a: GO:0033591 ! response to L-ascorbic acid -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071326 ! cellular response to monosaccharide stimulus created_by: mah @@ -387825,7 +385574,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:mah] synonym: "cellular response to vitamin A acid" EXACT [GOC:mah] is_a: GO:0032526 ! response to retinoic acid -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -387839,7 +385587,6 @@ def: "Any process that results in a change in state or activity of a cell (in te synonym: "cellular response to thiamin" EXACT [GOC:mah] synonym: "cellular response to thiamine" EXACT [GOC:mah] is_a: GO:0010266 ! response to vitamin B1 -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound @@ -387853,7 +385600,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:mah] synonym: "cellular response to riboflavin" EXACT [GOC:mah] is_a: GO:0033274 ! response to vitamin B2 -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound @@ -387878,7 +385624,6 @@ name: cellular response to vitamin B6 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah] is_a: GO:0034516 ! response to vitamin B6 -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound @@ -387946,7 +385691,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:mah] synonym: "cellular response to vitamin K1" EXACT [GOC:mah] is_a: GO:0032573 ! response to phylloquinone -is_a: GO:0071295 ! cellular response to vitamin is_a: GO:1901655 ! cellular response to ketone created_by: mah creation_date: 2009-12-10T04:37:18Z @@ -387967,8 +385711,6 @@ name: cellular response to acetate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:mah] is_a: GO:0010034 ! response to acetate -is_a: GO:0071229 ! cellular response to acid chemical -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -387990,10 +385732,8 @@ name: cellular response to caffeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:mah] is_a: GO:0031000 ! response to caffeine -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071415 ! cellular response to purine-containing compound -is_a: GO:0071466 ! cellular response to xenobiotic stimulus created_by: mah creation_date: 2009-12-10T04:52:51Z @@ -388002,11 +385742,9 @@ id: GO:0071314 name: cellular response to cocaine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0042220 ! response to cocaine is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah creation_date: 2009-12-10T04:53:20Z @@ -388016,10 +385754,8 @@ id: GO:0071315 name: cellular response to morphine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0043278 ! response to morphine is_a: GO:0071317 ! cellular response to isoquinoline alkaloid -is_a: GO:0071466 ! cellular response to xenobiotic stimulus created_by: mah creation_date: 2009-12-10T04:53:46Z @@ -388029,8 +385765,7 @@ name: cellular response to nicotine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:mah] is_a: GO:0035094 ! response to nicotine -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0097237 ! cellular response to toxic substance +is_a: GO:0070887 ! cellular response to chemical stimulus created_by: mah creation_date: 2009-12-10T05:05:05Z @@ -388052,9 +385787,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:mah] synonym: "cellular response to adenosine 5'-triphosphate" EXACT [GOC:mah] synonym: "cellular response to adenosine triphosphate" EXACT [GOC:mah] -is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0033198 ! response to ATP -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -388066,9 +385799,6 @@ id: GO:0071319 name: cellular response to benzoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071229 ! cellular response to acid chemical -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0080021 ! response to benzoic acid is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -388124,7 +385854,6 @@ name: cellular response to chitin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:mah] is_a: GO:0010200 ! response to chitin -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -388388,7 +386117,7 @@ creation_date: 2009-12-11T02:41:12Z id: GO:0071346 name: cellular response to interferon-gamma namespace: biological_process -def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far." [GOC:mah, PR:000000017] +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far." [GOC:mah] synonym: "cellular response to gamma-interferon" RELATED [GOC:mah] synonym: "cellular response to immune interferon" EXACT [GOC:mah] synonym: "cellular response to type II IFN" BROAD [GOC:mah] @@ -388512,7 +386241,7 @@ creation_date: 2009-12-11T02:51:37Z id: GO:0071357 name: cellular response to type I interferon namespace: biological_process -def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah, PR:000025848] +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah] synonym: "cellular response to type I IFN" EXACT [GOC:mah] is_a: GO:0034340 ! response to type I interferon is_a: GO:0071345 ! cellular response to cytokine stimulus @@ -388560,10 +386289,7 @@ id: GO:0071361 name: cellular response to ethanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0045471 ! response to ethanol -is_a: GO:0071236 ! cellular response to antibiotic -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:0097306 ! cellular response to alcohol created_by: mah creation_date: 2009-12-11T03:02:59Z @@ -388617,7 +386343,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [GOC:mah] synonym: "cellular response to IBA stimulus" EXACT [GOC:mah] synonym: "cellular response to indole-3-butyric acid stimulus" NARROW [GOC:mah] -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071365 ! cellular response to auxin stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound @@ -388668,7 +386393,6 @@ def: "Any process that results in a change in state or activity of a cell (in te synonym: "cellular response to gibberellic acid stimulus" NARROW [GOC:mah] is_a: GO:0009739 ! response to gibberellin is_a: GO:0032870 ! cellular response to hormone stimulus -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -388859,7 +386583,6 @@ name: cellular response to cortisol stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [GOC:mah] synonym: "cellular response to hydrocortisone stimulus" EXACT [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0051414 ! response to cortisol is_a: GO:0071385 ! cellular response to glucocorticoid stimulus is_a: GO:0097306 ! cellular response to alcohol @@ -388894,7 +386617,6 @@ id: GO:0071390 name: cellular response to ecdysone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah] -is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0035075 ! response to ecdysone is_a: GO:0036315 ! cellular response to sterol is_a: GO:0097306 ! cellular response to alcohol @@ -388908,8 +386630,8 @@ name: cellular response to estrogen stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:mah] synonym: "cellular response to oestrogen stimulus" EXACT [GOC:mah] +is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0043627 ! response to estrogen -is_a: GO:0070887 ! cellular response to chemical stimulus created_by: mah creation_date: 2009-12-11T04:09:56Z @@ -388920,7 +386642,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah] synonym: "cellular response to E2 stimulus" EXACT [GOC:mah] is_a: GO:0032355 ! response to estradiol -is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -388933,7 +386654,6 @@ name: cellular response to progesterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:mah] is_a: GO:0032570 ! response to progesterone -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071383 ! cellular response to steroid hormone stimulus is_a: GO:1901655 ! cellular response to ketone created_by: mah @@ -388944,7 +386664,6 @@ id: GO:0071394 name: cellular response to testosterone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:mah] -is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0033574 ! response to testosterone is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound @@ -388959,7 +386678,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:mah] is_a: GO:0009753 ! response to jasmonic acid is_a: GO:0032870 ! cellular response to hormone stimulus -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah creation_date: 2009-12-11T04:13:34Z @@ -388991,7 +386709,6 @@ name: cellular response to fatty acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:mah] is_a: GO:0070542 ! response to fatty acid -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -389074,7 +386791,6 @@ name: cellular response to methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:mah] is_a: GO:0033986 ! response to methanol -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0097306 ! cellular response to alcohol created_by: mah creation_date: 2009-12-14T02:54:44Z @@ -389118,12 +386834,9 @@ name: cellular response to cycloheximide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:mah] synonym: "cellular response to actidione" EXACT [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0046898 ! response to cycloheximide -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone created_by: mah @@ -389148,7 +386861,6 @@ comment: Note that this term is in the subset of terms that should not be used f subset: gocheck_do_not_manually_annotate is_a: GO:0014076 ! response to fluoxetine is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071466 ! cellular response to xenobiotic stimulus created_by: mah creation_date: 2009-12-14T03:09:58Z @@ -389157,9 +386869,7 @@ id: GO:0071412 name: cellular response to genistein namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah] -is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0033595 ! response to genistein -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071413 ! cellular response to hydroxyisoflavone created_by: mah creation_date: 2009-12-14T03:10:04Z @@ -389181,8 +386891,6 @@ name: cellular response to methotrexate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:mah] is_a: GO:0031427 ! response to methotrexate -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -389241,10 +386949,7 @@ name: cellular response to amphetamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:mah] is_a: GO:0001975 ! response to amphetamine -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071418 ! cellular response to amine stimulus -is_a: GO:0071466 ! cellular response to xenobiotic stimulus -is_a: GO:0097237 ! cellular response to toxic substance created_by: mah creation_date: 2009-12-14T04:09:02Z @@ -389281,7 +386986,6 @@ def: "The process in which succinate is transported across a membrane." [GOC:mah comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "succinate membrane transport" EXACT [] synonym: "transmembrane succinate transport" EXACT [GOC:mah] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015744 ! succinate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: mah @@ -389566,10 +387270,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:mah] synonym: "cellular response to salicylate stimulus" EXACT [GOC:dph] is_a: GO:0009751 ! response to salicylic acid -is_a: GO:0032870 ! cellular response to hormone stimulus -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071229 ! cellular response to acid chemical -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -389633,9 +387333,7 @@ name: cellular response to singlet oxygen namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:mah] is_a: GO:0000304 ! response to singlet oxygen -is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0034614 ! cellular response to reactive oxygen species -is_a: GO:0035690 ! cellular response to drug created_by: mah creation_date: 2009-12-16T04:39:46Z @@ -389698,9 +387396,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:mah] is_a: GO:0010193 ! response to ozone is_a: GO:0034614 ! cellular response to reactive oxygen species -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071229 ! cellular response to acid chemical -is_a: GO:0071236 ! cellular response to antibiotic created_by: mah creation_date: 2009-12-16T04:45:59Z @@ -390225,7 +387920,6 @@ name: response to heparin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf] is_a: GO:0010243 ! response to organonitrogen compound -is_a: GO:0061476 ! response to anticoagulant is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2009-12-18T03:33:49Z @@ -390235,7 +387929,6 @@ id: GO:0071504 name: cellular response to heparin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0071503 ! response to heparin is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -390248,12 +387941,7 @@ name: response to mycophenolic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [GOC:mah, GOC:yaf] synonym: "response to mycophenolate" EXACT [GOC:mah] -is_a: GO:0001101 ! response to acid chemical -is_a: GO:0009410 ! response to xenobiotic stimulus -is_a: GO:0010046 ! response to mycotoxin is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2009-12-18T03:46:00Z @@ -390264,12 +387952,7 @@ name: cellular response to mycophenolic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [GOC:mah, GOC:yaf] synonym: "cellular response to mycophenolate" EXACT [GOC:mah] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0036146 ! cellular response to mycotoxin -is_a: GO:0071229 ! cellular response to acid chemical -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:0071505 ! response to mycophenolic acid is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -390431,8 +388114,9 @@ id: GO:0071518 name: autoinducer-2 kinase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP." [GOC:imk, PMID:17274596, PMID:20025244] -synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [CHEBI:425228, GOC:mah] +synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [CHEBI:29484, GOC:mah] xref: MetaCyc:RXN0-5461 +xref: RHEA:15377 is_a: GO:0016301 ! kinase activity created_by: mah creation_date: 2010-01-06T05:08:17Z @@ -390483,6 +388167,7 @@ namespace: molecular_function def: "Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3." [MetaCyc:URUR-RXN, PMID:19935661, PMID:20038185] xref: EC:3.5.3.26 xref: MetaCyc:URUR-RXN +xref: RHEA:25241 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines created_by: mah creation_date: 2010-01-07T01:43:58Z @@ -390775,9 +388460,7 @@ name: response to dexamethasone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf] synonym: "response to dexamethasone stimulus" EXACT [GOC:dos] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0051384 ! response to glucocorticoid -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: mah creation_date: 2010-01-13T01:24:40Z @@ -390787,9 +388470,7 @@ id: GO:0071549 name: cellular response to dexamethasone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071385 ! cellular response to glucocorticoid stimulus -is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:0071548 ! response to dexamethasone is_a: GO:1901655 ! cellular response to ketone created_by: mah @@ -390919,7 +388600,7 @@ name: histone demethylase activity (H3-K27 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein." [GOC:sp, PMID:20622853] xref: EC:1.14.11.68 -xref: Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16-INK4A promoter" +xref: Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter" xref: Reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin" xref: Reactome:R-HSA-5617887 "HOXC4 chromatin is activated" is_a: GO:0032452 ! histone demethylase activity @@ -391614,7 +389295,6 @@ synonym: "acyl-CoA biosynthesis" EXACT [GOC:mah] synonym: "acyl-CoA formation" EXACT [GOC:mah] synonym: "acyl-CoA synthesis" EXACT [GOC:mah] is_a: GO:0006637 ! acyl-CoA metabolic process -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process @@ -392501,7 +390181,6 @@ synonym: "response to indole-3-carbinol" EXACT [CHEBI:24814] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol -is_a: GO:0097327 ! response to antineoplastic agent created_by: mah creation_date: 2010-02-18T04:05:09Z @@ -392511,7 +390190,6 @@ name: cellular response to indole-3-methanol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf] synonym: "cellular response to indole-3-carbinol" EXACT [CHEBI:24814] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0071680 ! response to indole-3-methanol @@ -393055,7 +390733,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance -is_a: GO:0097366 ! response to bronchodilator is_a: GO:1901698 ! response to nitrogen compound created_by: mah creation_date: 2010-03-17T04:03:38Z @@ -393066,7 +390743,6 @@ name: cellular response to nitric oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] is_a: GO:0034614 ! cellular response to reactive oxygen species -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0071731 ! response to nitric oxide is_a: GO:1902170 ! cellular response to reactive nitrogen species @@ -393732,7 +391408,6 @@ synonym: "bacillithiol metabolism" EXACT [GOC:mah] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process -is_a: GO:0051186 ! cofactor metabolic process created_by: mah creation_date: 2010-09-02T11:13:47Z @@ -393748,7 +391423,6 @@ synonym: "bacillithiol synthesis" EXACT [GOC:mah] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0071792 ! bacillithiol metabolic process created_by: mah creation_date: 2010-09-02T11:16:04Z @@ -394294,7 +391968,7 @@ creation_date: 2010-09-10T02:15:42Z id: GO:0071847 name: TNFSF11-mediated signaling pathway namespace: biological_process -def: "A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:18606301, PR:000002107] +def: "A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:18606301] synonym: "RANKL-mediated signaling pathway" EXACT [GOC:BHF] synonym: "receptor activator of nuclear factor kappa-B ligand signaling pathway" EXACT [Wikipedia:RANKL] synonym: "TNF-related activation-induced cytokine-mediated signaling pathway" EXACT [Wikipedia:RANKL] @@ -394739,7 +392413,6 @@ def: "Interacting selectively and non-covalently with the amine 1-(4-iodo-2,5-di synonym: "(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding" EXACT [CHEBI:100436] synonym: "1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding" EXACT [PMID:19057895] synonym: "4-iodo-2,5-dimethoxyphenylisopropylamine binding" EXACT [PubChem_Compound:1229] -is_a: GO:0008144 ! drug binding is_a: GO:0043176 ! amine binding is_a: GO:0097159 ! organic cyclic compound binding created_by: mah @@ -394775,7 +392448,7 @@ creation_date: 2010-09-14T12:50:40Z id: GO:0071889 name: 14-3-3 protein binding namespace: molecular_function -def: "Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, InterPro:IPR000308, PMID:15167810, PMID:19575580, PR:000003237] +def: "Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580] is_a: GO:0005515 ! protein binding created_by: mah creation_date: 2010-09-14T01:21:50Z @@ -395300,7 +392973,6 @@ comment: Note that this term is not intended for use in annotating lateral movem synonym: "thiamin transmembrane transport" EXACT [GOC:mah] synonym: "thiamine membrane transport" EXACT [] synonym: "vitamin B1 transmembrane transport" EXACT [GOC:mah] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015888 ! thiamine transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0045117 ! azole transmembrane transport @@ -395344,7 +393016,6 @@ namespace: biological_process def: "The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551] synonym: "vitamin A uptake and transport" RELATED [GOC:rs] is_a: GO:0015718 ! monocarboxylic acid transport -is_a: GO:0015893 ! drug transport is_a: GO:0034633 ! retinol transport is_a: GO:0051180 ! vitamin transport created_by: mah @@ -395356,7 +393027,6 @@ name: vitamin A import namespace: biological_process def: "The directed movement of vitamin A into a cell or organelle. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551] synonym: "vitamin A uptake" EXACT [GOC:mah, GOC:rs] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0071938 ! vitamin A transport is_a: GO:1905039 ! carboxylic acid transmembrane transport @@ -395662,6 +393332,7 @@ namespace: molecular_function def: "Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+." [MetaCyc:RXN0-5122] synonym: "LPS core heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY] xref: MetaCyc:RXN0-5122 +xref: RHEA:29923 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity created_by: mah creation_date: 2010-10-14T05:13:31Z @@ -395672,6 +393343,7 @@ name: lipid A-core heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+." [MetaCyc:RXN0-5127] xref: MetaCyc:RXN0-5127 +xref: RHEA:30019 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity created_by: mah creation_date: 2010-10-14T05:15:22Z @@ -399997,21 +397669,13 @@ is_a: GO:0008287 ! protein serine/threonine phosphatase complex created_by: mah creation_date: 2010-11-15T03:32:27Z -[Term] -id: GO:0072358 -name: cardiovascular system development -namespace: biological_process -def: "The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels." [GOC:mah, UBERON:0004535] -is_a: GO:0048731 ! system development -relationship: part_of GO:0072359 ! circulatory system development -created_by: mah -creation_date: 2010-11-16T11:25:49Z - [Term] id: GO:0072359 name: circulatory system development namespace: biological_process +alt_id: GO:0072358 def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] +synonym: "cardiovascular system development" NARROW [] is_a: GO:0048731 ! system development created_by: mah creation_date: 2010-11-16T11:27:39Z @@ -400022,7 +397686,7 @@ name: vascular cord development namespace: biological_process def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077] is_a: GO:0048856 ! anatomical structure development -relationship: part_of GO:0072358 ! cardiovascular system development +relationship: part_of GO:0072359 ! circulatory system development created_by: mah creation_date: 2010-11-16T11:46:55Z @@ -400321,7 +397985,6 @@ def: "The chemical reactions and pathways involving flavin adenine dinucleotide, synonym: "FAD or FADH2 metabolic process" EXACT [] synonym: "flavin adenine dinucleotide metabolism" EXACT [] synonym: "flavin-adenine dinucleotide metabolic process" EXACT [] -is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process created_by: mah @@ -400337,7 +398000,6 @@ synonym: "flavin adenine dinucleotide anabolism" EXACT [] synonym: "flavin adenine dinucleotide biosynthesis" EXACT [] synonym: "flavin adenine dinucleotide formation" EXACT [] synonym: "flavin adenine dinucleotide synthesis" EXACT [] -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process @@ -400353,7 +398015,6 @@ synonym: "FAD or FADH2 catabolic process" EXACT [] synonym: "flavin adenine dinucleotide breakdown" EXACT [] synonym: "flavin adenine dinucleotide catabolism" EXACT [] synonym: "flavin adenine dinucleotide degradation" EXACT [] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process @@ -400365,7 +398026,6 @@ id: GO:0072390 name: phenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process created_by: mah creation_date: 2010-12-06T04:05:51Z @@ -400375,7 +398035,6 @@ id: GO:0072391 name: phenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072390 ! phenol metabolic process created_by: mah @@ -400386,9 +398045,7 @@ id: GO:0072392 name: phenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072390 ! phenol metabolic process created_by: mah creation_date: 2010-12-06T04:08:44Z @@ -401773,29 +399430,21 @@ relationship: part_of GO:0071465 ! cellular response to desiccation created_by: mah creation_date: 2010-12-21T11:30:31Z -[Term] -id: GO:0072516 -name: viral assembly compartment -namespace: cellular_component -def: "A membrane-bounded compartment that forms in the cytoplasm of virus-infected cells, in which virus assembly takes place." [GOC:BHF, PMID:20374631] -synonym: "viral assembly site" RELATED [GOC:BHF] -synonym: "virion assembly compartment" EXACT [GOC:mah] -is_a: GO:0043231 ! intracellular membrane-bounded organelle -relationship: part_of GO:0005737 ! cytoplasm -created_by: mah -creation_date: 2010-12-21T03:08:42Z - [Term] id: GO:0072517 name: host cell viral assembly compartment namespace: cellular_component +alt_id: GO:0072516 def: "A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place." [GOC:BHF, PMID:20374631] synonym: "host cell viral assembly site" RELATED [GOC:BHF] synonym: "host cell virion assembly compartment" EXACT [GOC:mah] +synonym: "viral assembly compartment" EXACT [] +synonym: "viral assembly site" RELATED [] +synonym: "virion assembly compartment" EXACT [] is_a: GO:0033648 ! host intracellular membrane-bounded organelle is_a: GO:0039714 ! cytoplasmic viral factory created_by: mah -creation_date: 2010-12-21T03:14:06Z +creation_date: 2010-12-21T03:08:42Z [Term] id: GO:0072518 @@ -402124,7 +399773,6 @@ name: L-DOPA binding namespace: molecular_function def: "Interacting selectively and non-covalently with L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid." [GOC:mah, GOC:vw] synonym: "L-dopa binding" EXACT [CHEBI:15765] -is_a: GO:0008144 ! drug binding is_a: GO:0016597 ! amino acid binding is_a: GO:0072341 ! modified amino acid binding is_a: GO:0097159 ! organic cyclic compound binding @@ -402536,6 +400184,7 @@ namespace: molecular_function def: "Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine." [GOC:kad, MetaCyc:RXN0-363, PMID:21235647] synonym: "xanthosine ribohydrolase activity" EXACT [GOC:kad] xref: MetaCyc:RXN0-363 +xref: RHEA:27994 is_a: GO:0008477 ! purine nucleosidase activity created_by: mah creation_date: 2011-02-08T04:38:31Z @@ -402612,7 +400261,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [GOC:mah] synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263] synonym: "oxygen metabolism" EXACT [GOC:mah] -is_a: GO:0017144 ! drug metabolic process +is_a: GO:0044237 ! cellular metabolic process created_by: mah creation_date: 2011-02-11T10:46:51Z @@ -402705,419 +400354,96 @@ is_a: GO:0072594 ! establishment of protein localization to organelle created_by: mah creation_date: 2011-02-14T02:23:41Z -[Term] -id: GO:0072601 -name: interleukin-3 secretion -namespace: biological_process -def: "The regulated release of interleukin-3 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-3 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032632 ! interleukin-3 production - -[Term] -id: GO:0072602 -name: interleukin-4 secretion -namespace: biological_process -def: "The regulated release of interleukin-4 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-4 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032633 ! interleukin-4 production - -[Term] -id: GO:0072603 -name: interleukin-5 secretion -namespace: biological_process -def: "The regulated release of interleukin-5 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-5 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032634 ! interleukin-5 production - -[Term] -id: GO:0072604 -name: interleukin-6 secretion -namespace: biological_process -def: "The regulated release of interleukin-6 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-6 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032635 ! interleukin-6 production - -[Term] -id: GO:0072605 -name: interleukin-7 secretion -namespace: biological_process -def: "The regulated release of interleukin-7 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-7 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032636 ! interleukin-7 production - -[Term] -id: GO:0072606 -name: interleukin-8 secretion -namespace: biological_process -def: "The regulated release of interleukin-8 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-8 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032637 ! interleukin-8 production - -[Term] -id: GO:0072607 -name: interleukin-9 secretion -namespace: biological_process -def: "The regulated release of interleukin-9 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-9 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032638 ! interleukin-9 production - -[Term] -id: GO:0072608 -name: interleukin-10 secretion -namespace: biological_process -def: "The regulated release of interleukin-10 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-10 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032613 ! interleukin-10 production - -[Term] -id: GO:0072609 -name: interleukin-11 secretion -namespace: biological_process -def: "The regulated release of interleukin-11 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-11 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032614 ! interleukin-11 production - -[Term] -id: GO:0072610 -name: interleukin-12 secretion -namespace: biological_process -def: "The regulated release of interleukin-12 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "CLMF secretion" NARROW [GOC:BHF] -synonym: "IL-12 secretion" EXACT [GOC:BHF] -synonym: "IL12 secretion" EXACT [GOC:BHF] -synonym: "interleukin-12 complex secretion" EXACT [GOC:BHF] -synonym: "NKSF secretion" NARROW [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032615 ! interleukin-12 production - -[Term] -id: GO:0072611 -name: interleukin-13 secretion -namespace: biological_process -def: "The regulated release of interleukin-13 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-13 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032616 ! interleukin-13 production - -[Term] -id: GO:0072612 -name: interleukin-14 secretion -namespace: biological_process -def: "The regulated release of interleukin-14 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-14 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032617 ! interleukin-14 production - -[Term] -id: GO:0072613 -name: interleukin-15 secretion -namespace: biological_process -def: "The regulated release of interleukin-15 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-15 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032618 ! interleukin-15 production - -[Term] -id: GO:0072614 -name: interleukin-16 secretion -namespace: biological_process -def: "The regulated release of interleukin-16 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-16 secretion" EXACT [GOC:BHF] -synonym: "IL16 secretion" EXACT [GOC:BHF] -synonym: "LCF secretion" NARROW [GOC:BHF] -synonym: "pro-interleukin-16 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032619 ! interleukin-16 production - -[Term] -id: GO:0072615 -name: interleukin-17 secretion -namespace: biological_process -def: "The regulated release of any member of the interleukin-17 family of cytokines from a cell." [GOC:add, GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "CTLA-8 secretion" EXACT [GOC:BHF] -synonym: "Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:BHF] -synonym: "IL-17 secretion" EXACT [GOC:BHF] -synonym: "IL-17A secretion" EXACT [GOC:BHF] -synonym: "IL17A secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032620 ! interleukin-17 production - -[Term] -id: GO:0072616 -name: interleukin-18 secretion -namespace: biological_process -def: "The regulated release of interleukin-18 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IGIF secretion" EXACT [GOC:BHF] -synonym: "IL-18 secretion" EXACT [GOC:BHF] -synonym: "IL1F4 secretion" NARROW [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032621 ! interleukin-18 production - -[Term] -id: GO:0072617 -name: interleukin-19 secretion -namespace: biological_process -def: "The regulated release of interleukin-19 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-19 secretion" EXACT [GOC:BHF] -synonym: "ZMDA1 secretion" NARROW [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032622 ! interleukin-19 production - -[Term] -id: GO:0072618 -name: interleukin-20 secretion -namespace: biological_process -def: "The regulated release of interleukin-20 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-20 secretion" EXACT [GOC:BHF] -synonym: "ZCYTO10 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032624 ! interleukin-20 production - -[Term] -id: GO:0072619 -name: interleukin-21 secretion -namespace: biological_process -def: "The regulated release of interleukin-21 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-21 secretion" EXACT [GOC:BHF] -synonym: "IL21 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032625 ! interleukin-21 production - -[Term] -id: GO:0072620 -name: interleukin-22 secretion -namespace: biological_process -def: "The regulated release of interleukin-22 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-22 secretion" EXACT [GOC:BHF] -synonym: "IL22 secretion" EXACT [GOC:BHF] -synonym: "ILTIF secretion" EXACT [GOC:BHF] -synonym: "ZCYTO18 secretion" NARROW [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032626 ! interleukin-22 production - -[Term] -id: GO:0072621 -name: interleukin-23 secretion -namespace: biological_process -def: "The regulated release of interleukin-23 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-23 secretion" EXACT [GOC:BHF] -synonym: "IL23 secretion" EXACT [GOC:BHF] -synonym: "interleukin-23 complex secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032627 ! interleukin-23 production - -[Term] -id: GO:0072622 -name: interleukin-24 secretion -namespace: biological_process -def: "The regulated release of interleukin-24 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-24 secretion" EXACT [GOC:BHF] -synonym: "IL24 secretion" EXACT [GOC:BHF] -synonym: "MDA7 secretion" EXACT [GOC:BHF] -synonym: "ST16 secretion" NARROW [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032628 ! interleukin-24 production - -[Term] -id: GO:0072623 -name: interleukin-25 secretion -namespace: biological_process -def: "The regulated release of interleukin-25 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-25 secretion" EXACT [GOC:BHF] -synonym: "IL17E secretion" EXACT [GOC:BHF] -synonym: "IL25 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032629 ! interleukin-25 production - -[Term] -id: GO:0072624 -name: interleukin-26 secretion -namespace: biological_process -def: "The regulated release of interleukin-26 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "AK155 secretion" NARROW [GOC:BHF] -synonym: "IL-26 secretion" EXACT [GOC:BHF] -synonym: "IL26 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032630 ! interleukin-26 production - -[Term] -id: GO:0072625 -name: interleukin-27 secretion -namespace: biological_process -def: "The regulated release of interleukin-27 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-27 secretion" EXACT [GOC:BHF] -synonym: "IL27 secretion" EXACT [GOC:BHF] -synonym: "interleukin-27 complex secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032631 ! interleukin-27 production - -[Term] -id: GO:0072626 -name: interleukin-35 secretion -namespace: biological_process -def: "The regulated release of interleukin-35 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-35 secretion" EXACT [GOC:BHF] -synonym: "IL35 secretion" EXACT [GOC:BHF] -synonym: "interleukin-35 complex secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0070753 ! interleukin-35 production - [Term] id: GO:0072627 name: interleukin-28A production namespace: biological_process -def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] +alt_id: GO:0072628 +def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IL-28A production" EXACT [GOC:BHF] synonym: "IL28A production" EXACT [GOC:BHF] synonym: "interferon lambda 2 production" EXACT [GOC:BHF] +synonym: "interleukin-28A secretion" NARROW [] is_a: GO:0034343 ! type III interferon production -[Term] -id: GO:0072628 -name: interleukin-28A secretion -namespace: biological_process -def: "The regulated release of interleukin-28A from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-28A secretion" EXACT [GOC:BHF] -synonym: "IL28A secretion" EXACT [GOC:BHF] -synonym: "interferon lambda 2 secretion" EXACT [GOC:BHF] -is_a: GO:0072644 ! type III interferon secretion -relationship: part_of GO:0072627 ! interleukin-28A production - [Term] id: GO:0072629 name: interleukin-28B production namespace: biological_process -def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] +alt_id: GO:0072630 +def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IL-28B production" EXACT [GOC:BHF] synonym: "IL28B production" EXACT [GOC:BHF] synonym: "interferon lambda 3 production" EXACT [GOC:BHF] +synonym: "interleukin-28B secretion" NARROW [] is_a: GO:0034343 ! type III interferon production -[Term] -id: GO:0072630 -name: interleukin-28B secretion -namespace: biological_process -def: "The regulated release of interleukin-28B from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-28B secretion" EXACT [GOC:BHF] -synonym: "IL28B secretion" EXACT [GOC:BHF] -synonym: "interferon lambda 3 secretion" EXACT [GOC:BHF] -is_a: GO:0072644 ! type III interferon secretion -relationship: part_of GO:0072629 ! interleukin-28B production - [Term] id: GO:0072631 name: interleukin-29 production namespace: biological_process -def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] +alt_id: GO:0072632 +def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IL-29 production" EXACT [GOC:BHF] synonym: "IL29 production" EXACT [GOC:BHF] synonym: "interferon lambda 1 production" EXACT [GOC:BHF] +synonym: "interleukin-29 secretion" NARROW [] is_a: GO:0034343 ! type III interferon production -[Term] -id: GO:0072632 -name: interleukin-29 secretion -namespace: biological_process -def: "The regulated release of interleukin-29 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-29 secretion" EXACT [GOC:BHF] -synonym: "IL29 secretion" EXACT [GOC:BHF] -synonym: "interferon lambda 1 secretion" EXACT [GOC:BHF] -is_a: GO:0072644 ! type III interferon secretion -relationship: part_of GO:0072631 ! interleukin-29 production - [Term] id: GO:0072633 name: interleukin-30 production namespace: biological_process +alt_id: GO:0072634 def: "The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-30 production" EXACT [GOC:BHF] synonym: "interleukin-30 complex production" EXACT [GOC:BHF] +synonym: "interleukin-30 secretion" NARROW [] is_a: GO:0001816 ! cytokine production -[Term] -id: GO:0072634 -name: interleukin-30 secretion -namespace: biological_process -def: "The regulated release of interleukin-30 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-30 secretion" EXACT [GOC:BHF] -synonym: "interleukin-30 complex secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0072633 ! interleukin-30 production - [Term] id: GO:0072635 name: interleukin-31 production namespace: biological_process +alt_id: GO:0072636 def: "The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] synonym: "IL-31 production" EXACT [GOC:BHF] +synonym: "interleukin-31 secretion" NARROW [] is_a: GO:0001816 ! cytokine production -[Term] -id: GO:0072636 -name: interleukin-31 secretion -namespace: biological_process -def: "The regulated release of interleukin-31 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-31 secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0072635 ! interleukin-31 production - [Term] id: GO:0072637 name: interleukin-32 production namespace: biological_process -def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] +alt_id: GO:0072638 +alt_id: GO:0150188 +def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:23729669] synonym: "IL-32 production" EXACT [GOC:BHF] synonym: "IL32 production" EXACT [GOC:BHF] +synonym: "interleukin-32 biosynthetic process" NARROW [] +synonym: "interleukin-32 secretion" NARROW [] synonym: "NK4 production" NARROW [GOC:BHF] synonym: "TAIF production" NARROW [GOC:BHF] is_a: GO:0001816 ! cytokine production - -[Term] -id: GO:0072638 -name: interleukin-32 secretion -namespace: biological_process -def: "The regulated release of interleukin-32 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "IL-32 secretion" EXACT [GOC:BHF] -synonym: "IL32 secretion" EXACT [GOC:BHF] -synonym: "NK4 secretion" NARROW [GOC:BHF] -synonym: "TAIF secretion" NARROW [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0072637 ! interleukin-32 production +created_by: bc +creation_date: 2020-02-21T10:26:40Z [Term] id: GO:0072639 name: interleukin-33 production namespace: biological_process -def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] +alt_id: GO:0072640 +alt_id: GO:0150126 +def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:29778524] synonym: "C9orf26 production" NARROW [GOC:BHF] synonym: "IL-33 production" EXACT [GOC:BHF] synonym: "IL1F11 production" NARROW [GOC:BHF] synonym: "IL33 production" EXACT [GOC:BHF] +synonym: "interleukin-33 biosynthetic process" NARROW [] +synonym: "interleukin-33 secretion" NARROW [] synonym: "NF-HEV production" EXACT [GOC:BHF] is_a: GO:0001816 ! cytokine production -[Term] -id: GO:0072640 -name: interleukin-33 secretion -namespace: biological_process -def: "The regulated release of interleukin-33 from a cell." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] -synonym: "C9orf26 secretion" NARROW [GOC:BHF] -synonym: "IL-33 secretion" EXACT [GOC:BHF] -synonym: "IL1F11 secretion" NARROW [GOC:BHF] -synonym: "IL33 secretion" EXACT [GOC:BHF] -synonym: "NF-HEV secretion" EXACT [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0072639 ! interleukin-33 production - [Term] id: GO:0072641 name: type I interferon secretion @@ -403127,132 +400453,62 @@ synonym: "type I IFN secretion" EXACT [GOC:mah] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0032606 ! type I interferon production -[Term] -id: GO:0072642 -name: interferon-alpha secretion -namespace: biological_process -def: "The regulated release of interferon-alpha from a cell." [GOC:BHF, GOC:mah, PMID:15546383] -synonym: "IFN-alpha secretion" EXACT [GOC:mah] -synonym: "IFNA secretion" EXACT [GOC:BHF] -is_a: GO:0072641 ! type I interferon secretion -relationship: part_of GO:0032607 ! interferon-alpha production - -[Term] -id: GO:0072643 -name: interferon-gamma secretion -namespace: biological_process -def: "The regulated release of interferon-gamma from a cell." [GOC:BHF, GOC:mah, PMID:15546383] -synonym: "IFN-gamma secretion" EXACT [GOC:mah] -synonym: "IFNG secretion" EXACT [GOC:BHF] -synonym: "type II IFN secretion" BROAD [GOC:mah] -synonym: "type II interferon secretion" BROAD [GOC:BHF] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0032609 ! interferon-gamma production - -[Term] -id: GO:0072644 -name: type III interferon secretion -namespace: biological_process -def: "The regulated release of type III interferon from a cell. Interferon lambda is the only member of the type III interferon found so far." [GOC:BHF, GOC:mah, PMID:15546383] -synonym: "type III IFN secretion" EXACT [GOC:mah] -is_a: GO:0050663 ! cytokine secretion -relationship: part_of GO:0034343 ! type III interferon production - [Term] id: GO:0072645 name: interferon-delta production namespace: biological_process +alt_id: GO:0072646 def: "The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-delta production" EXACT [GOC:mah] synonym: "IFND production" EXACT [GOC:BHF] +synonym: "interferon-delta secretion" NARROW [] is_a: GO:0032606 ! type I interferon production -[Term] -id: GO:0072646 -name: interferon-delta secretion -namespace: biological_process -def: "The regulated release of interferon-delta from a cell." [GOC:BHF, GOC:mah, PMID:15546383] -synonym: "IFN-delta secretion" EXACT [GOC:mah] -synonym: "IFND secretion" EXACT [GOC:BHF] -is_a: GO:0072641 ! type I interferon secretion -relationship: part_of GO:0072645 ! interferon-delta production - [Term] id: GO:0072647 name: interferon-epsilon production namespace: biological_process +alt_id: GO:0072648 def: "The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-epsilon production" EXACT [GOC:mah] synonym: "IFNE production" EXACT [GOC:BHF] +synonym: "interferon-epsilon secretion" NARROW [] is_a: GO:0032606 ! type I interferon production -[Term] -id: GO:0072648 -name: interferon-epsilon secretion -namespace: biological_process -def: "The regulated release of interferon-epsilon from a cell." [GOC:BHF, GOC:mah, PMID:15546383] -synonym: "IFN-epsilon secretion" EXACT [GOC:mah] -synonym: "IFNE secretion" EXACT [GOC:BHF] -is_a: GO:0072641 ! type I interferon secretion -relationship: part_of GO:0072647 ! interferon-epsilon production - [Term] id: GO:0072649 name: interferon-kappa production namespace: biological_process +alt_id: GO:0072650 def: "The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-kappa production" EXACT [GOC:mah] synonym: "IFNK production" EXACT [GOC:BHF] +synonym: "interferon-kappa secretion" NARROW [] is_a: GO:0032606 ! type I interferon production -[Term] -id: GO:0072650 -name: interferon-kappa secretion -namespace: biological_process -def: "The regulated release of interferon-kappa from a cell." [GOC:BHF, GOC:mah, PMID:15546383] -synonym: "IFN-kappa secretion" EXACT [GOC:mah] -synonym: "IFNK secretion" EXACT [GOC:BHF] -is_a: GO:0072641 ! type I interferon secretion -relationship: part_of GO:0072649 ! interferon-kappa production - [Term] id: GO:0072651 name: interferon-tau production namespace: biological_process +alt_id: GO:0072652 def: "The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-tau production" EXACT [GOC:mah] +synonym: "IFN-tau secretion" EXACT [GOC:mah] synonym: "IFNT production" EXACT [GOC:BHF] +synonym: "interferon-tau secretion" NARROW [] is_a: GO:0032606 ! type I interferon production -[Term] -id: GO:0072652 -name: interferon-tau secretion -namespace: biological_process -def: "The regulated release of interferon-tau from a cell." [GOC:BHF, GOC:mah, PMID:15546383] -synonym: "IFN-tau secretion" EXACT [GOC:mah] -synonym: "IFNT secretion" EXACT [GOC:BHF] -is_a: GO:0072641 ! type I interferon secretion -relationship: part_of GO:0072651 ! interferon-tau production - [Term] id: GO:0072653 name: interferon-omega production namespace: biological_process +alt_id: GO:0072654 def: "The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] synonym: "IFN-omega production" EXACT [GOC:mah] synonym: "IFNW production" EXACT [GOC:BHF] +synonym: "interferon-omega secretion" NARROW [] is_a: GO:0032606 ! type I interferon production -[Term] -id: GO:0072654 -name: interferon-omega secretion -namespace: biological_process -def: "The regulated release of interferon-omega from a cell." [GOC:BHF, GOC:mah, PMID:15546383] -synonym: "IFN-omega secretion" EXACT [GOC:mah] -synonym: "IFNW secretion" EXACT [GOC:BHF] -is_a: GO:0072641 ! type I interferon secretion -relationship: part_of GO:0072653 ! interferon-omega production - [Term] id: GO:0072655 name: establishment of protein localization to mitochondrion @@ -403874,8 +401130,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [GOC:mah] synonym: "response to HU" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance -is_a: GO:0097327 ! response to antineoplastic agent -is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901698 ! response to nitrogen compound created_by: mah creation_date: 2012-04-11T04:15:42Z @@ -403886,7 +401140,6 @@ name: cellular response to hydroxyurea namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [GOC:mah] synonym: "cellular response to HU" EXACT [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0072710 ! response to hydroxyurea is_a: GO:1901699 ! cellular response to nitrogen compound @@ -403901,8 +401154,6 @@ def: "Any process that results in a change in state or activity of a cell or an synonym: "response to TBZ" EXACT [CHEBI:45979, GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug -is_a: GO:0060992 ! response to fungicide created_by: mah creation_date: 2012-04-11T04:23:56Z @@ -403912,12 +401163,9 @@ name: cellular response to thiabendazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [GOC:mah] synonym: "cellular response to TBZ" EXACT [CHEBI:45979, GOC:mah] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0072712 ! response to thiabendazole -is_a: GO:0097237 ! cellular response to toxic substance created_by: mah creation_date: 2012-04-11T04:24:19Z @@ -403966,8 +401214,7 @@ id: GO:0072718 name: response to cisplatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [GOC:mah] -is_a: GO:0009636 ! response to toxic substance -is_a: GO:0097327 ! response to antineoplastic agent +is_a: GO:0042221 ! response to chemical created_by: mah creation_date: 2012-04-30T11:31:05Z @@ -403976,9 +401223,8 @@ id: GO:0072719 name: cellular response to cisplatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug +is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:0072718 ! response to cisplatin -is_a: GO:0097237 ! cellular response to toxic substance created_by: mah creation_date: 2012-04-30T11:31:12Z @@ -404013,7 +401259,6 @@ name: response to amitrole namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [GOC:mah] synonym: "response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah] -is_a: GO:0009635 ! response to herbicide is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound created_by: mah @@ -404028,7 +401273,6 @@ synonym: "cellular response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:m is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0072722 ! response to amitrole -is_a: GO:0097237 ! cellular response to toxic substance created_by: mah creation_date: 2012-05-31T10:51:52Z @@ -404108,7 +401352,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-05-31T11:30:32Z @@ -404118,7 +401361,6 @@ id: GO:0072731 name: cellular response to papulacandin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [GOC:mah] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0072730 ! response to papulacandin B @@ -404162,10 +401404,9 @@ id: GO:0072735 name: response to tert-butyl hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [GOC:mah] -synonym: "response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:365419] +synonym: "response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090] synonym: "response to t-BOOH" EXACT [GOC:mah] is_a: GO:0033195 ! response to alkyl hydroperoxide -is_a: GO:0046677 ! response to antibiotic created_by: mah creation_date: 2012-07-17T10:33:00Z @@ -404174,9 +401415,8 @@ id: GO:0072736 name: cellular response to tert-butyl hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [GOC:mah] -synonym: "cellular response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:365419] +synonym: "cellular response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090] synonym: "cellular response to t-BOOH" EXACT [GOC:mah] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071448 ! cellular response to alkyl hydroperoxide is_a: GO:0072735 ! response to tert-butyl hydroperoxide @@ -404249,9 +401489,7 @@ id: GO:0072743 name: cellular response to erythromycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:mah] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1901323 ! response to erythromycin is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -404263,8 +401501,6 @@ id: GO:0072744 name: cellular response to trichodermin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071362 ! cellular response to ether is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901324 ! response to trichodermin @@ -404276,7 +401512,6 @@ id: GO:0072745 name: cellular response to antimycin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:mah] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901325 ! response to antimycin A @@ -404289,8 +401524,6 @@ id: GO:0072746 name: cellular response to tetracycline namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901326 ! response to tetracycline is_a: GO:1901655 ! cellular response to ketone @@ -404302,8 +401535,6 @@ id: GO:0072747 name: cellular response to chloramphenicol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901322 ! response to chloramphenicol is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -404317,7 +401548,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus (FK506) stimulus." [GOC:mah] synonym: "cellular response to FK506" EXACT [CHEBI:61057] synonym: "cellular response to tacrolimus hydrate" EXACT [CHEBI:61057] -is_a: GO:0035690 ! cellular response to drug +is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901327 ! response to tacrolimus created_by: mah creation_date: 2012-08-31T12:34:32Z @@ -404327,8 +401558,6 @@ id: GO:0072749 name: cellular response to cytochalasin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0036146 ! cellular response to mycotoxin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901328 ! response to cytochalasin B @@ -404341,7 +401570,6 @@ id: GO:0072750 name: cellular response to leptomycin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:mah] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071398 ! cellular response to fatty acid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901344 ! response to leptomycin B @@ -404364,8 +401592,6 @@ id: GO:0072752 name: cellular response to rapamycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071362 ! cellular response to ether is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound @@ -404400,11 +401626,8 @@ id: GO:0072755 name: cellular response to benomyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901561 ! response to benomyl is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -404416,7 +401639,6 @@ name: cellular response to paraquat namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:mah] is_a: GO:0071310 ! cellular response to organic substance -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901562 ! response to paraquat created_by: mah creation_date: 2012-11-07T12:08:59Z @@ -404427,7 +401649,6 @@ name: cellular response to camptothecin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:mah] synonym: "cellular response to CPT" EXACT [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097306 ! cellular response to alcohol @@ -404459,7 +401680,6 @@ id: GO:0072760 name: cellular response to GW 7647 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:mah] -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901593 ! response to GW 7647 is_a: GO:1901699 ! cellular response to nitrogen compound @@ -404484,11 +401704,8 @@ id: GO:0072762 name: cellular response to carbendazim namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901597 ! response to carbendazim is_a: GO:1901701 ! cellular response to oxygen-containing compound created_by: mah @@ -404511,7 +401728,6 @@ id: GO:0072764 name: cellular response to reversine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:mah] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071415 ! cellular response to purine-containing compound is_a: GO:1901596 ! response to reversine is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -405057,7 +402273,7 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. is_a: GO:0022603 ! regulation of anatomical structure morphogenesis -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process is_a: GO:0044127 ! regulation of development of symbiont in host intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host @@ -408383,6 +405599,7 @@ namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol." [MetaCyc:RXN-9685, PMID:17705488] xref: EC:5.4.99 xref: MetaCyc:RXN-9685 +xref: RHEA:31987 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] @@ -408400,6 +405617,7 @@ name: (E,E)-geranyllinalool synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate." [MetaCyc:RXN-10441, PMID:18398052] xref: MetaCyc:RXN-10441 +xref: RHEA:38155 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] @@ -408429,6 +405647,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate." [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047] xref: EC:4.2.3 xref: MetaCyc:RXN-8414 +xref: RHEA:28294 is_a: GO:0009975 ! cyclase activity is_a: GO:0010334 ! sesquiterpene synthase activity @@ -408439,6 +405658,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate." [PMID:12566586, PMID:9442047] xref: EC:4.2.3 xref: MetaCyc:RXN-8415 +xref: RHEA:31895 is_a: GO:0009975 ! cyclase activity is_a: GO:0010334 ! sesquiterpene synthase activity @@ -408463,7 +405683,6 @@ id: GO:0080020 name: regulation of coenzyme A biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A." [PMID:18621975] -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015937 ! coenzyme A biosynthetic process @@ -408475,10 +405694,7 @@ name: response to benzoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [PMID:18753285] synonym: "response to benzoic acid stimulus" EXACT [GOC:dos] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] @@ -408524,7 +405740,6 @@ def: "Any process that results in a change in state or activity of a cell or an synonym: "response to IBA stimulus" EXACT [] synonym: "response to indole-3-butyric acid stimulus" NARROW [] synonym: "response to indolebutyric acid stimulus" EXACT [GOC:dos] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0009733 ! response to auxin is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound @@ -408597,7 +405812,6 @@ id: GO:0080033 name: response to nitrite namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:dhl, PMID:17951451] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound @@ -408724,6 +405938,7 @@ namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + phosphate = L-galactose-1-P + GDP." [EC:2.7.7.69, PMID:18463094] xref: EC:2.7.7.69 xref: MetaCyc:RXNQT-4141 +xref: RHEA:27698 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] @@ -408733,6 +405948,7 @@ namespace: molecular_function def: "Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP." [PMID:18463094] xref: EC:2.7.7.78 xref: MetaCyc:RXN-12486 +xref: RHEA:30387 is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity [Term] @@ -409219,6 +406435,7 @@ def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimeth xref: EC:2.1.1.71 xref: KEGG_REACTION:R01320 xref: MetaCyc:RXN4FS-2 +xref: RHEA:32739 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity created_by: dhl @@ -409435,7 +406652,6 @@ synonym: "adenosine monophosphate transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport -is_a: GO:0015893 ! drug transport is_a: GO:0051503 ! adenine nucleotide transport created_by: dhl creation_date: 2009-04-28T04:01:37Z @@ -409645,7 +406861,6 @@ name: regulation of jasmonic acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid." [GOC:dhl] is_a: GO:0019217 ! regulation of fatty acid metabolic process -is_a: GO:0032350 ! regulation of hormone metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009694 ! jasmonic acid metabolic process relationship: regulates GO:0009694 ! jasmonic acid metabolic process @@ -409658,7 +406873,6 @@ name: regulation of jasmonic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid." [GOC:dhl] is_a: GO:0042304 ! regulation of fatty acid biosynthetic process -is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0080140 ! regulation of jasmonic acid metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009695 ! jasmonic acid biosynthetic process @@ -409672,7 +406886,7 @@ name: regulation of salicylic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid." [GOC:dhl] is_a: GO:0010337 ! regulation of salicylic acid metabolic process -is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009697 ! salicylic acid biosynthetic process relationship: regulates GO:0009697 ! salicylic acid biosynthetic process @@ -409717,6 +406931,7 @@ xref: EC:4.4.1.1 xref: MetaCyc:LCYSDESULF-RXN xref: Reactome:R-HSA-1614591 "Excess cysteine yields lanthionine and H2S" xref: Reactome:R-HSA-1614614 "Cysteine is degraded to serine and H2S" +xref: RHEA:24931 is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: dhl creation_date: 2010-01-27T04:50:43Z @@ -409759,6 +406974,7 @@ namespace: molecular_function def: "Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine." [MetaCyc:RXN-6722, PMID:10852939] synonym: "S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity" EXACT [] xref: MetaCyc:RXN-6722 +xref: RHEA:36099 is_a: GO:0008171 ! O-methyltransferase activity created_by: dhl creation_date: 2010-03-26T04:19:39Z @@ -409771,7 +406987,6 @@ def: "Any process that activates or increases the frequency, rate or extent of s synonym: "positive regulation of salicylic acid mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway -is_a: GO:2001040 ! positive regulation of cellular response to drug relationship: positively_regulates GO:0009863 ! salicylic acid mediated signaling pathway created_by: dhl creation_date: 2010-05-20T03:10:46Z @@ -409919,7 +407134,6 @@ id: GO:0080164 name: regulation of nitric oxide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:DHL] -is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process relationship: regulates GO:0046209 ! nitric oxide metabolic process @@ -409987,8 +407201,7 @@ namespace: biological_process def: "The process in which hydrogen peroxide is transported across a membrane." [GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "hydrogen peroxide membrane transport" EXACT [] -is_a: GO:0006855 ! drug transmembrane transport -is_a: GO:0051181 ! cofactor transport +is_a: GO:0055085 ! transmembrane transport created_by: dhl creation_date: 2010-09-23T05:12:14Z @@ -411940,10 +409153,11 @@ is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0089701 -name: U2AF +name: U2AF complex namespace: cellular_component def: "A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565] synonym: "U2 accessory factor" EXACT [] +synonym: "U2AF" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0005634 ! nucleus @@ -411969,10 +409183,7 @@ name: L-glutamate transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0006835 ! dicarboxylic acid transport -is_a: GO:0006836 ! neurotransmitter transport -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0032974 ! amino acid transmembrane export from vacuole -is_a: GO:0046618 ! drug export is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport [Term] @@ -411989,7 +409200,6 @@ name: L-ornithine transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0032974 ! amino acid transmembrane export from vacuole -is_a: GO:0046618 ! drug export is_a: GO:1903352 ! L-ornithine transmembrane transport [Term] @@ -411998,7 +409208,6 @@ name: L-lysine transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-lysine out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0032974 ! amino acid transmembrane export from vacuole -is_a: GO:0046618 ! drug export is_a: GO:1903401 ! L-lysine transmembrane transport [Term] @@ -412007,7 +409216,6 @@ name: L-histidine transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane." [PMID:21307582] is_a: GO:0032974 ! amino acid transmembrane export from vacuole -is_a: GO:0046618 ! drug export is_a: GO:0089709 ! L-histidine transmembrane transport is_a: GO:1902024 ! L-histidine transport is_a: GO:1990822 ! basic amino acid transmembrane transport @@ -412017,7 +409225,6 @@ id: GO:0089709 name: L-histidine transmembrane transport namespace: biological_process def: "The directed movement of L-histidine across a membrane." [PMID:21307582] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015801 ! aromatic amino acid transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:0098655 ! cation transmembrane transport @@ -412043,6 +409250,7 @@ name: UDP-N-acetyl-D-mannosamine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+." [EC:1.1.1.336] xref: EC:1.1.1.336 +xref: RHEA:25780 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -412736,7 +409944,6 @@ id: GO:0090056 name: regulation of chlorophyll metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll." [GOC:dph, GOC:tb] -is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0015994 ! chlorophyll metabolic process @@ -417171,7 +414378,6 @@ namespace: molecular_function def: "Enables the transfer of nicotinate from one side of a membrane to the other." [GOC:tb] xref: Reactome:R-HSA-8869603 "SLC22A13 transports NCA from extracellular region to cytosol" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity -is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:2001142 ! nicotinate transport created_by: tb creation_date: 2011-10-19T11:09:59Z @@ -418073,7 +415279,6 @@ id: GO:0090514 name: L-tyrosine transmembrane import into vacuole namespace: biological_process def: "The directed movement of L-tyrosine into the vacuole across the vacuolar membrane." [GOC:al] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015828 ! tyrosine transport is_a: GO:0032975 ! amino acid transmembrane import into vacuole is_a: GO:0098655 ! cation transmembrane transport @@ -418458,8 +415663,8 @@ creation_date: 2013-10-24T16:07:20Z id: GO:0090555 name: phosphatidylethanolamine flippase activity namespace: molecular_function -def: "Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, RHEA:36440] -comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation. +def: "Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, PMID:20043909, RHEA:36440] +comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaftlet of a membrane). synonym: "ATP-dependent phosphatidylethanolamine transporter activity" RELATED [] synonym: "ATPase-coupled phosphatidylethanolamine transporter activity" BROAD [] synonym: "phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] @@ -418516,6 +415721,7 @@ namespace: molecular_function def: "Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [BRENDA:2.5.1.108, GOC:pde, PMID:15485916] xref: MetaCyc:RXN-11371 xref: Reactome:R-HSA-5358494 "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2" +xref: RHEA:36783 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: tb creation_date: 2014-03-27T14:58:50Z @@ -419865,18 +417071,6 @@ property_value: RO:0002161 NCBITaxon:4751 created_by: tb creation_date: 2016-08-25T17:08:33Z -[Term] -id: GO:0090699 -name: repair of merotelic kinetochore attachment defect, meiosis I -namespace: biological_process -def: "The cell cycle process that corrects the anomalous association of a single chromatid kinetochore with meiotic spindle microtubules emanating from both spindle poles at meiosis I." [GOC:vw, PMID:21920317] -synonym: "correction of merotelic kinetochore attachment, meiosis I" EXACT [] -is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect -is_a: GO:1903046 ! meiotic cell cycle process -relationship: part_of GO:0043060 ! meiotic metaphase I plate congression -created_by: tb -creation_date: 2016-08-29T14:03:26Z - [Term] id: GO:0090700 name: maintenance of plant organ identity @@ -420380,6 +417574,7 @@ def: "Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trim synonym: "4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity" EXACT [] synonym: "TMTT synthase activity" EXACT [] xref: MetaCyc:RXN-8620 +xref: RHEA:13545 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen created_by: pr creation_date: 2011-03-16T04:37:20Z @@ -420900,8 +418095,6 @@ synonym: "L-glutamate biosynthesis" EXACT [] synonym: "L-glutamate formation" EXACT [] synonym: "L-glutamate synthesis" EXACT [] is_a: GO:0006537 ! glutamate biosynthetic process -is_a: GO:0017144 ! drug metabolic process -is_a: GO:0042133 ! neurotransmitter metabolic process created_by: pr creation_date: 2011-05-24T04:30:38Z @@ -421055,7 +418248,6 @@ synonym: "response to T4" EXACT [Wikipedia:Thyroxine] synonym: "response to T4 stimulus" EXACT [Wikipedia:Thyroxine] synonym: "response to thyroxine stimulus" EXACT [GOC:dos] is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid is_a: GO:0097066 ! response to thyroid hormone is_a: GO:1904386 ! response to L-phenylalanine derivative @@ -421068,7 +418260,6 @@ name: cellular response to thyroxine stimulus namespace: biological_process def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872] synonym: "cellular response to T4 stimulus" EXACT [Wikipedia:Thyroxine] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097067 ! cellular response to thyroid hormone stimulus @@ -421189,41 +418380,45 @@ creation_date: 2011-06-17T10:03:55Z [Term] id: GO:0097081 -name: vascular smooth muscle cell fate commitment +name: vascular associated smooth muscle cell fate commitment namespace: biological_process def: "The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] +synonym: "vascular smooth muscle cell fate commitment" EXACT [] is_a: GO:0042693 ! muscle cell fate commitment -relationship: part_of GO:0035886 ! vascular smooth muscle cell differentiation +relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation created_by: pr creation_date: 2011-06-20T03:51:52Z [Term] id: GO:0097082 -name: vascular smooth muscle cell fate specification +name: vascular associated smooth muscle cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] +synonym: "vascular smooth muscle cell fate specification" EXACT [] is_a: GO:0042694 ! muscle cell fate specification -relationship: part_of GO:0097081 ! vascular smooth muscle cell fate commitment +relationship: part_of GO:0097081 ! vascular associated smooth muscle cell fate commitment created_by: pr creation_date: 2011-06-20T03:56:21Z [Term] id: GO:0097083 -name: vascular smooth muscle cell fate determination +name: vascular associated smooth muscle cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] +synonym: "vascular smooth muscle cell fate determination" EXACT [] is_a: GO:0007521 ! muscle cell fate determination -relationship: part_of GO:0097081 ! vascular smooth muscle cell fate commitment +relationship: part_of GO:0097081 ! vascular associated smooth muscle cell fate commitment created_by: pr creation_date: 2011-06-20T04:00:28Z [Term] id: GO:0097084 -name: vascular smooth muscle cell development +name: vascular associated smooth muscle cell development namespace: biological_process def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] +synonym: "vascular smooth muscle cell development" EXACT [] is_a: GO:0055001 ! muscle cell development -relationship: part_of GO:0035886 ! vascular smooth muscle cell differentiation +relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation created_by: pr creation_date: 2011-06-20T04:03:08Z @@ -421250,17 +418445,19 @@ creation_date: 2011-06-22T11:17:52Z id: GO:0097087 name: interleukin-17A production namespace: biological_process -def: "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000001138, Wikipedia:Interleukin_17] +alt_id: GO:0150154 +def: "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PMID:27901018] synonym: "IL-17A production" EXACT [] +synonym: "interleukin-17A biosynthetic process" NARROW [] is_a: GO:0032620 ! interleukin-17 production -created_by: pr +created_by: bc creation_date: 2011-06-23T11:31:10Z [Term] id: GO:0097088 name: interleukin-17F production namespace: biological_process -def: "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000001142, Wikipedia:Interleukin_17] +def: "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, Wikipedia:Interleukin_17] synonym: "IL-17F production" EXACT [] is_a: GO:0032620 ! interleukin-17 production created_by: pr @@ -421703,7 +418900,7 @@ creation_date: 2011-08-01T01:47:16Z id: GO:0097128 name: cyclin D1-CDK4 complex namespace: cellular_component -def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026740] +def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: pr creation_date: 2011-08-01T01:48:36Z @@ -421757,7 +418954,7 @@ creation_date: 2011-08-01T01:57:41Z id: GO:0097134 name: cyclin E1-CDK2 complex namespace: cellular_component -def: "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026745] +def: "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: pr creation_date: 2011-08-01T01:58:42Z @@ -421766,7 +418963,7 @@ creation_date: 2011-08-01T01:58:42Z id: GO:0097135 name: cyclin E2-CDK2 complex namespace: cellular_component -def: "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619, PR:000026746] +def: "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex created_by: pr creation_date: 2011-08-01T01:59:57Z @@ -422012,7 +419209,6 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings." [GOC:sjw, PMID:7583672] synonym: "PCB binding" EXACT [] synonym: "polychlorobiphenyl binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding created_by: pr creation_date: 2011-09-23T02:33:22Z @@ -423010,7 +420206,6 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin." [GOC:sl, PMID:21307292] synonym: "catechin gallate binding" BROAD [] synonym: "EGCG binding" EXACT [] -is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:0097243 ! flavonoid binding is_a: GO:1901363 ! heterocyclic compound binding @@ -423118,6 +420313,7 @@ namespace: molecular_function def: "Catalysis of the reaction: leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)." [GOC:mw, KEGG_REACTION:R03864, PMID:8394361, PMID:9461497] synonym: "leukotriene B4 12-hydroxydehydrogenase activity" EXACT [] xref: Reactome:R-HSA-2161567 "LTB4 is oxidised to 12-oxoLTB4 by PTGR1" +xref: RHEA:50608 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors created_by: pr creation_date: 2012-03-07T02:07:41Z @@ -423251,6 +420447,7 @@ def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopen synonym: "(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [] synonym: "2-trans,6-trans-farnesyl diphosphate activity" EXACT [] xref: Reactome:R-HSA-2162253 "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer" +xref: RHEA:27802 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: pr creation_date: 2012-03-20T01:00:23Z @@ -423277,10 +420474,11 @@ creation_date: 2012-03-20T03:39:20Z [Term] id: GO:0097272 -name: ammonia homeostasis +name: ammonium homeostasis namespace: biological_process -def: "Any biological process involved in the maintenance of an internal steady state of ammonia." [GOC:yaf, PMID:12695560] -is_a: GO:0048878 ! chemical homeostasis +def: "Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560] +synonym: "ammonia homeostasis" EXACT [] +is_a: GO:0055067 ! monovalent inorganic cation homeostasis created_by: pr creation_date: 2012-03-22T02:51:22Z @@ -423304,11 +420502,12 @@ creation_date: 2012-03-22T02:53:39Z [Term] id: GO:0097275 -name: cellular ammonia homeostasis +name: cellular ammonium homeostasis namespace: biological_process -def: "Any biological process involved in the maintenance of an internal steady state of ammonia at the level of the cell." [GOC:yaf, PMID:12695560] -is_a: GO:0055082 ! cellular chemical homeostasis -is_a: GO:0097272 ! ammonia homeostasis +def: "Any biological process involved in the maintenance of an internal steady state of ammonium at the level of the cell." [GOC:yaf, PMID:12695560] +synonym: "cellular ammonia homeostasis" EXACT [] +is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis +is_a: GO:0097272 ! ammonium homeostasis created_by: pr creation_date: 2012-03-22T02:54:38Z @@ -423670,7 +420869,6 @@ name: response to farnesol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [GOC:pr] is_a: GO:0033993 ! response to lipid -is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol created_by: pr creation_date: 2012-05-15T03:51:31Z @@ -423680,7 +420878,6 @@ id: GO:0097308 name: cellular response to farnesol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [GOC:di, PMID:11425711] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071396 ! cellular response to lipid is_a: GO:0097306 ! cellular response to alcohol is_a: GO:0097307 ! response to farnesol @@ -423871,7 +421068,7 @@ id: GO:0097328 name: response to carboplatin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus." [GOC:pr] -is_a: GO:0097327 ! response to antineoplastic agent +is_a: GO:0042221 ! response to chemical created_by: pr creation_date: 2012-06-12T10:50:34Z @@ -423891,9 +421088,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097327 ! response to antineoplastic agent -is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2012-06-12T10:53:35Z @@ -423905,9 +421099,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097327 ! response to antineoplastic agent -is_a: GO:0097329 ! response to antimetabolite is_a: GO:1903416 ! response to glycoside created_by: pr creation_date: 2012-06-12T10:55:29Z @@ -423928,7 +421119,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097332 ! response to antipsychotic drug created_by: pr creation_date: 2012-06-12T11:00:04Z @@ -423940,7 +421130,6 @@ def: "Any process that results in a change in state or activity of a cell or an is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol -is_a: GO:0097332 ! response to antipsychotic drug created_by: pr creation_date: 2012-06-12T11:01:14Z @@ -423951,7 +421140,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097332 ! response to antipsychotic drug created_by: pr creation_date: 2012-06-12T11:03:22Z @@ -423962,7 +421150,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097332 ! response to antipsychotic drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2012-06-12T11:04:31Z @@ -423974,7 +421161,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms." [GOC:pr] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097332 ! response to antipsychotic drug created_by: pr creation_date: 2012-06-12T11:05:31Z @@ -423983,10 +421169,8 @@ id: GO:0097338 name: response to clozapine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus." [GOC:pr] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097332 ! response to antipsychotic drug created_by: pr creation_date: 2012-06-12T11:07:01Z @@ -423997,7 +421181,6 @@ namespace: biological_process def: "The process in which glycolate is transported across a membrane. Glycolate is the anion of hydroxyethanoic acid (glycolic acid)." [GOC:am, PMID:11283302, PMID:11785976] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "glycolate membrane transport" EXACT [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:1900866 ! glycolate transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: pr @@ -424106,6 +421289,7 @@ id: GO:0097350 name: neutrophil clearance namespace: biological_process def: "The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms." [GOC:BHF, PMID:21957127] +is_a: GO:0043277 ! apoptotic cell clearance is_a: GO:0048771 ! tissue remodeling relationship: has_part GO:0006909 ! phagocytosis relationship: part_of GO:0001780 ! neutrophil homeostasis @@ -424432,6 +421616,7 @@ namespace: molecular_function def: "Catalysis of the reaction: dIDP + H2O = dIMP + phosphate." [GOC:pde, PMID:20385596] synonym: "deoxyinosine-diphosphatase activity" EXACT [] xref: Reactome:R-HSA-2509793 "NUDT16 hydrolyses dIDP to dIMP" +xref: RHEA:35211 is_a: GO:0097382 ! deoxynucleoside-diphosphatase activity created_by: pr creation_date: 2012-10-11T16:04:40Z @@ -429888,7 +427073,7 @@ id: GO:0098600 name: selenomethionine gamma-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid." [PMID:11578145, PMID:16037612, PMID:16444005] -xref: Reactome:R-HSA-2408537 "Excess SeMet is cleaved into MeSeH by CTH" +xref: Reactome:R-HSA-2408537 "Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH" is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: dos creation_date: 2014-04-15T15:00:28Z @@ -429899,6 +427084,7 @@ name: selenomethionine adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine." [PMID:2339986] xref: Reactome:R-HSA-2408551 "SeMet is converted to AdoSeMet by MAT" +xref: RHEA:31211 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups created_by: dos creation_date: 2014-04-15T15:15:03Z @@ -429936,7 +427122,8 @@ id: GO:0098606 name: selenocystathionine gamma-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid." [PMID:6456763] -xref: Reactome:R-HSA-2408543 "SeCysta is hydrolysed to Sec by CTH" +xref: Reactome:R-HSA-2408543 "SeCysta is hydrolysed to Sec by PXLP-K212-CTH" +xref: RHEA:31151 is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: dos creation_date: 2014-04-16T11:20:00Z @@ -429946,7 +427133,7 @@ id: GO:0098607 name: methylselenocysteine deselenhydrase activity namespace: molecular_function def: "Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol." [PMID:17451884, PMID:20383543] -xref: Reactome:R-HSA-2408539 "MeSec is hydrolysed to MeSeH by CTH" +xref: Reactome:R-HSA-2408539 "MeSec is hydrolysed to MeSeH by PXLP-K212-CTH" is_a: GO:0016846 ! carbon-sulfur lyase activity created_by: dos creation_date: 2014-04-16T11:24:12Z @@ -430055,7 +427242,7 @@ id: GO:0098621 name: phosphoseryl-selenocysteinyl-tRNA selenium transferase activity namespace: molecular_function def: "Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid." [PMID:17142313, PMID:19608919] -xref: Reactome:R-HSA-2408555 "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by SEPSECS tetramer" +xref: Reactome:R-HSA-2408555 "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer" is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA @@ -430065,6 +427252,7 @@ name: selenodiglutathione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + selenodiglutathione + NADPH => gluthathioselenol + glutathione + NADP+." [PMID:1569062] xref: Reactome:R-HSA-2408542 "GSSeSG is reduced to GSSeH and GSH by GSR" +xref: RHEA:34927 is_a: GO:0015036 ! disulfide oxidoreductase activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor @@ -430140,10 +427328,10 @@ is_a: GO:0098743 ! cell aggregation id: GO:0098631 name: cell adhesion mediator activity namespace: molecular_function -def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell." [Wikipedia:Cell_adhesion] +def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion] synonym: "cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell adhesion" EXACT [] -is_a: GO:0005488 ! binding +is_a: GO:0050839 ! cell adhesion molecule binding intersection_of: GO:0005488 ! binding intersection_of: part_of GO:0007155 ! cell adhesion relationship: part_of GO:0007155 ! cell adhesion @@ -430155,7 +427343,6 @@ namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion] synonym: "cell-cell adhesion molecule" EXACT [] synonym: "protein binding involved in cell-cell adhesion" EXACT [] -is_a: GO:0005515 ! protein binding is_a: GO:0098631 ! cell adhesion mediator activity intersection_of: GO:0005515 ! protein binding intersection_of: part_of GO:0098609 ! cell-cell adhesion @@ -430305,12 +427492,14 @@ is_a: GO:0098644 ! complex of collagen trimers [Term] id: GO:0098649 -name: response to peptidyl-dipeptidase A inhibitor +name: obsolete response to peptidyl-dipeptidase A inhibitor namespace: biological_process -def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidyl-dipeptidase A inhibitor stimulus." [GOC:dos] +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidyl-dipeptidase A inhibitor stimulus." [GOC:dos] +comment: This term was obsoleted because it does not represent a physiological process. synonym: "response to ACE inhibitor" NARROW [] synonym: "response to angiotensin-converting enzyme inhibitor" NARROW [] -is_a: GO:0042493 ! response to drug +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19725 xsd:anyURI +is_obsolete: true [Term] id: GO:0098650 @@ -430475,7 +427664,6 @@ namespace: cellular_component def: "A protein complex that is capable of G protein-coupled serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie] synonym: "G-protein coupled serotonin receptor complex" EXACT [] is_a: GO:0098665 ! serotonin receptor complex -is_a: GO:0098878 ! neurotransmitter receptor complex created_by: dos creation_date: 2016-12-21T12:28:12Z @@ -431004,7 +428192,6 @@ def: "The directed movement of L-glutamate from outside of a cell, across the pl synonym: "L-glutamate import into cell" EXACT [] synonym: "L-glutamate(1-) import across plasma membrane" BROAD [] synonym: "L-glutamate(1-) import into cell" EXACT [] -is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0015813 ! L-glutamate transmembrane transport is_a: GO:0051938 ! L-glutamate import is_a: GO:0089718 ! amino acid import across plasma membrane @@ -431073,14 +428260,9 @@ alt_id: GO:1901688 def: "The directed movement of pantothenate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] synonym: "pantothenate import" RELATED [] synonym: "pantothenate import into cell" EXACT [] -is_a: GO:0015718 ! monocarboxylic acid transport -is_a: GO:0035461 ! vitamin transmembrane transport -is_a: GO:0042886 ! amide transport -is_a: GO:0051181 ! cofactor transport -is_a: GO:0072337 ! modified amino acid transport +is_a: GO:0015887 ! pantothenate transmembrane transport is_a: GO:0098657 ! import into cell is_a: GO:0098739 ! import across plasma membrane -is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: jl creation_date: 2012-12-06T13:02:23Z @@ -431618,15 +428800,6 @@ synonym: "mechanically-gated potassium channel activity" EXACT [] is_a: GO:0005267 ! potassium channel activity is_a: GO:0140135 ! mechanosensitive cation channel activity -[Term] -id: GO:0098783 -name: repair of mitotic merotelic kinetochore attachment defect -namespace: biological_process -def: "The cell cycle process that corrects the anomalous association of a single chromatid kinetochore with mitotic spindle microtubules emanating from both spindle poles (otherwise known as merotelic attachment to the spindle)." [PMID:21306900] -synonym: "correction of merotelic kinetochore attachment, mitotic" EXACT [] -synonym: "repair of mitotic merotelic kinetochore attachment defects" EXACT [] -is_a: GO:1990598 ! repair of mitotic mono-orientation defect - [Term] id: GO:0098784 name: biofilm matrix organization @@ -432153,7 +429326,6 @@ namespace: biological_process def: "The process in which a folic acid, or one of its derivatives (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) is transported across a membrane." [PMID:24745983] synonym: "folic acid transmembrane transport" RELATED [] synonym: "reduced folate transmembrane transport" NARROW [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015884 ! folic acid transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:1905039 ! carboxylic acid transmembrane transport @@ -432260,6 +429432,7 @@ namespace: molecular_function def: "Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane." [EC:4.7.1.1, GOC:dos, GOC:ik] synonym: "alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming)" EXACT [EC:4.7.1.1] xref: EC:4.7.1.1 +xref: RHEA:34707 is_a: GO:0018835 ! carbon phosphorus lyase activity [Term] @@ -434011,8 +431184,8 @@ is_a: GO:0032507 ! maintenance of protein location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0051286 ! cell tip relationship: occurs_in GO:0051286 ! cell tip -property_value: http://purl.org/dc/elements/1.1/creator "dos" xsd:string -property_value: http://purl.org/dc/elements/1.1/date 2016-06-30T15:17:41Z xsd:dateTime +created_by: dos +creation_date: 2016-06-30T15:17:41Z [Term] id: GO:0099018 @@ -434289,7 +431462,7 @@ creation_date: 2013-01-08T15:07:50Z id: GO:0099045 name: viral extrusion namespace: biological_process -def: "The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded." [PMID:2024582831, VZ:3951] +def: "The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded." [PMID:15567492, VZ:3951] xref: VZ:3951 is_a: GO:0046753 ! non-lytic viral release @@ -436831,7 +434004,7 @@ relationship: regulates GO:0030594 ! neurotransmitter receptor activity id: GO:0099602 name: neurotransmitter receptor regulator activity namespace: molecular_function -def: "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing." [GOC:dos, PMID:12740117, PMID:25172949] +def: "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing." [GOC:dos, PMID:12740117, PMID:18387948] is_a: GO:0030545 ! receptor regulator activity relationship: part_of GO:0099601 ! regulation of neurotransmitter receptor activity @@ -436957,6 +434130,7 @@ namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+." [GOC:al, GOC:dos] synonym: "UDP-GlcUA decarboxylase activity" EXACT [] xref: EC:1.1.1.305 +xref: RHEA:24702 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -436968,6 +434142,7 @@ synonym: "10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formy synonym: "ArnAFT activity" EXACT [] synonym: "UDP-L-Ara4N formyltransferase activity" EXACT [] xref: EC:2.1.2.13 +xref: RHEA:24706 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] @@ -436981,6 +434156,7 @@ synonym: "UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase" EXACT synonym: "UDP-Ara4O aminotransferase" EXACT [] synonym: "UDP-L-Ara4N transaminase" EXACT [] xref: EC:2.6.1.87 +xref: RHEA:24710 is_a: GO:0008483 ! transaminase activity [Term] @@ -436994,6 +434170,7 @@ synonym: "undecaprenyl phosphate-L-Ara4FN transferase activity" EXACT [] synonym: "undecaprenyl-phosphate Ara4FN transferase activity" EXACT [] xref: EC:2.4.2.53 xref: MetaCyc:RXN0-3521 +xref: RHEA:27722 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] @@ -438033,6 +435210,7 @@ def: "Catalysis of the hydrolysis of ubiquitin from proteins and other molecules comment: There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases. synonym: "deubiquitinase activity" EXACT [] synonym: "ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol" NARROW [] +xref: Reactome:R-HSA-9674127 "USP30 deubiquitinates ATM dimer:Ub-p-PEX5" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein created_by: mec @@ -438049,18 +435227,22 @@ is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0101007 -name: negative regulation of transcription from RNA polymerase II promoter in response to salt stress +name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to salt stress namespace: biological_process -def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec] -is_a: GO:0061416 ! regulation of transcription from RNA polymerase II promoter in response to salt stress +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec] +comment: This term was obsoleted because it represents a GO-CAM model. +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI +is_obsolete: true created_by: mec [Term] id: GO:0101008 -name: negative regulation of transcription from RNA polymerase II promoter in response to increased salt +name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to increased salt namespace: biological_process -def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec] -is_a: GO:0101007 ! negative regulation of transcription from RNA polymerase II promoter in response to salt stress +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec] +comment: This term was obsoleted because it represents a GO-CAM model. +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/12739 xsd:anyURI +is_obsolete: true created_by: mec [Term] @@ -438271,6 +435453,7 @@ name: 2-octaprenyl-6-hydroxyphenol methylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine." [EC:2.1.1.222] xref: MetaCyc:2-OCTAPRENYL-6-OHPHENOL-METHY-RXN +xref: RHEA:27770 is_a: GO:1990888 ! 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity [Term] @@ -438279,6 +435462,7 @@ name: 4-methyl-2-oxopentanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) <=> isovaleryl-CoA(4-) + carbon dioxide + NADH(2-)." [EC:1.2.1.-] xref: MetaCyc:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN +xref: RHEA:25177 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -438289,6 +435473,7 @@ def: "Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + a xref: EC:3.1.1.81 xref: MetaCyc:3.1.1.81-RXN xref: Reactome:R-HSA-8932633 "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE" +xref: RHEA:22576 is_a: GO:0046573 ! lactonohydrolase activity [Term] @@ -438324,6 +435509,7 @@ name: beta-D-galactose-importing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O <=> ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+." [EC:3.6.3.17] xref: MetaCyc:ABC-18-RXN +xref: RHEA:30011 is_a: GO:0015407 ! ATPase-coupled monosaccharide transmembrane transporter activity [Term] @@ -438336,8 +435522,10 @@ synonym: "thiosulfate transmembrane-transporting ATPase activity" RELATED [] synonym: "thiosulphate ABC transporter activity" EXACT [] xref: EC:7.3.2.3 xref: MetaCyc:ABC-7-RXN -is_a: GO:0015117 ! thiosulfate transmembrane transporter activity -is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity +xref: RHEA:29871 +is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity +relationship: part_of GO:0015709 ! thiosulfate transport property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14642 xsd:anyURI [Term] @@ -438354,15 +435542,18 @@ is_a: GO:0008168 ! methyltransferase activity id: GO:0102028 name: cystathionine gamma-synthase activity (acts on O-phosphohomoserine) namespace: molecular_function -def: "Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate." [EC:2.5.1.-, GOC:pz] +def: "Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate." [GOC:pz, PMID:5922970, PMID:9531508, RHEA:20397] +xref: EC:2.5.1.48 xref: MetaCyc:CYSPH-RXN +xref: RHEA:20397 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0102029 name: D-lactate dehydrogenase (quinone) activity namespace: molecular_function -def: "Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol." [EC:1.1.5.-, GOC:pz] +def: "Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol." [GOC:pz, PMID:10944213, PMID:4575624, RHEA:51468] +xref: EC:1.1.5.12 xref: MetaCyc:DLACTDEHYDROGFAD-RXN is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor @@ -438370,7 +435561,7 @@ is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, id: GO:0102030 name: dTDP-L-rhamnose synthetase activity namespace: molecular_function -def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+." [EC:1.1.1.-, GOC:pz, MetaCyc:DTDPRHAMSYNTHMULTI-RXN] +def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+." [GOC:pz] xref: MetaCyc:DTDPRHAMSYNTHMULTI-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -438392,6 +435583,7 @@ def: "Catalysis of the reaction: long-chain fatty acid + NADPH + H+ + O2 = an om synonym: "cytochrome P450 fatty acid omega-hydroxylase activity" RELATED [] xref: EC:1.14.13.205 xref: MetaCyc:RXN-16394 +xref: RHEA:56748 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14194 xsd:anyURI @@ -438399,7 +435591,8 @@ property_value: term_tracker_item https://github.com/geneontology/go-ontology/is id: GO:0102035 name: isobutyryl-CoA:FAD oxidoreductase activity namespace: molecular_function -def: "Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2." [EC:1.3.8.-, GOC:pz, MetaCyc:MEPROPCOA-FAD-RXN] +def: "Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2." [GOC:pz, PMID:3988734] +xref: EC:1.3.8.5 xref: MetaCyc:MEPROPCOA-FAD-RXN is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor @@ -438407,16 +435600,17 @@ is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, id: GO:0102036 name: methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]." [EC:2.1.1.258, GOC:pz] +def: "Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]." [EC:2.1.1.258, GOC:pz, PMID:7928975] xref: EC:2.1.1.258 xref: MetaCyc:METHCOCLTH-RXN +xref: RHEA:45200 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0102037 name: 4-nitrotoluene monooxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O." [EC:1.14.13.-, GOC:pz, MetaCyc:R361-RXN] +def: "Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O." [GOC:pz] xref: MetaCyc:R361-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -438424,7 +435618,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102038 name: 4-nitrobenzyl alcohol oxidase activity namespace: molecular_function -def: "Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide." [EC:1.1.3.-, GOC:pz] +def: "Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide." [GOC:pz] xref: MetaCyc:R362-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor @@ -438432,7 +435626,8 @@ is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, id: GO:0102039 name: alkylhydroperoxide reductase activity namespace: molecular_function -def: "Catalysis of the reaction: H2O + NAD + an alcohol <=> NADH + H+ + an organic hydroperoxide." [EC:1.8.1.-, GOC:pz] +def: "Catalysis of the reaction: H2O + NAD + an alcohol <=> NADH + H+ + an organic hydroperoxide." [GOC:pz, PMID:12517450] +xref: EC:1.11.1.26 xref: MetaCyc:R4-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor @@ -438440,7 +435635,7 @@ is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, id: GO:0102040 name: fumarate reductase (menaquinone) namespace: molecular_function -def: "Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone." [EC:1.3.5.4, GOC:pz] +def: "Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone." [GOC:pz, PMID:11850430, RHEA:27834] xref: EC:1.3.5.4 xref: MetaCyc:R601-RXN is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor @@ -438449,9 +435644,10 @@ is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, id: GO:0102041 name: 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase namespace: molecular_function -def: "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid." [EC:2.5.1.105, GOC:pz] +def: "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid." [GOC:pz, RHEA:35951] xref: EC:2.5.1.105 xref: MetaCyc:RXN-10009 +xref: RHEA:35951 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] @@ -438468,7 +435664,7 @@ is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors id: GO:0102043 name: isopentenyl phosphate kinase activity namespace: molecular_function -def: "Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-)." [EC:2.7.4.26, GOC:pz] +def: "Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-)." [GOC:pz, PMID:19928876, RHEA:33963] xref: EC:2.7.4.26 xref: MetaCyc:RXN-10068 xref: RHEA:33963 @@ -438478,7 +435674,7 @@ is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor id: GO:0102044 name: 3-chlorobenzoate-4,5-oxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [EC:1.14.12.-, GOC:pz] +def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [GOC:pz] xref: MetaCyc:RXN-10421 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor @@ -438486,7 +435682,7 @@ is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102045 name: 3-chlorobenzoate-3,4-oxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor." [EC:1.14.12.-, GOC:pz] +def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor." [GOC:pz, PMID:8285670] xref: MetaCyc:RXN-10422 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor @@ -438494,7 +435690,7 @@ is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102046 name: 3,4-dichlorobenzoate-4,5-oxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [EC:1.14.12.-, GOC:pz] +def: "Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [GOC:pz, PMID:9322760] xref: MetaCyc:RXN-10427 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor @@ -438502,7 +435698,7 @@ is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102047 name: indole-3-acetyl-glycine synthetase activity namespace: molecular_function -def: "Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +def: "Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623] xref: MetaCyc:RXN-10429 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds @@ -438510,7 +435706,7 @@ is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds id: GO:0102048 name: indole-3-acetyl-isoleucine synthetase activity namespace: molecular_function -def: "Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +def: "Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623] xref: MetaCyc:RXN-10430 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds @@ -438518,7 +435714,7 @@ is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds id: GO:0102049 name: indole-3-acetyl-methionine synthetase activity namespace: molecular_function -def: "Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +def: "Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623] xref: MetaCyc:RXN-10431 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds @@ -438550,7 +435746,7 @@ is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds id: GO:0102053 name: (-)-jasmonoyl-isoleucine synthetase activity namespace: molecular_function -def: "Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +def: "Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid." [GOC:pz] xref: MetaCyc:RXN-10435 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds @@ -438560,6 +435756,7 @@ name: maleylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O <=> H+ + maleate(2-) + pyruvate." [EC:3.7.1.-, GOC:pz] xref: MetaCyc:RXN-10447 +xref: RHEA:47956 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] @@ -438568,6 +435765,7 @@ name: 12-hydroxyjasmonate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate." [EC:2.8.2.-, GOC:pz] xref: MetaCyc:RXN-10451 +xref: RHEA:52728 is_a: GO:0008146 ! sulfotransferase activity [Term] @@ -438576,6 +435774,7 @@ name: 11-hydroxyjasmonate sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate." [EC:2.8.2.-, GOC:pz] xref: MetaCyc:RXN-10453 +xref: RHEA:52732 is_a: GO:0008146 ! sulfotransferase activity [Term] @@ -438601,6 +435800,7 @@ namespace: molecular_function def: "Catalysis of the reaction: prenyl diphosphate + 2 isopentenyl diphosphate <=> 2 diphosphoric acid + 2-cis,6-cis-farnesyl diphosphate." [EC:2.5.1.92, GOC:pz] xref: EC:2.5.1.92 xref: MetaCyc:RXN-10481 +xref: RHEA:27810 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] @@ -438674,6 +435874,7 @@ namespace: molecular_function def: "Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+." [EC:1.3.1.83, GOC:pz] xref: EC:1.3.1.83 xref: MetaCyc:RXN-10625 +xref: RHEA:26229 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -438693,6 +435894,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD <=> zerumbone + NADH + H+." [EC:1.1.1.326, GOC:pz] xref: EC:1.1.1.326 xref: MetaCyc:RXN-10629 +xref: RHEA:32327 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -438798,6 +436000,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H+ + rebeccamycin + S-adenosyl-L-homocysteine." [EC:2.1.1.164, GOC:pz] xref: EC:2.1.1.164 xref: MetaCyc:RXN-10847 +xref: RHEA:27353 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -438918,6 +436121,7 @@ namespace: molecular_function def: "Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ <=> 3-dehydro-6-deoxoteasterone + NADP + H2O." [EC:1.14.14.147, GOC:pz] xref: EC:1.14.14.147 xref: MetaCyc:RXN-11101 +xref: RHEA:27325 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -438927,6 +436131,7 @@ namespace: molecular_function def: "Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+." [EC:1.1.1.365, GOC:pz] xref: EC:1.1.1.365 xref: MetaCyc:RXN-11151 +xref: RHEA:26345 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -438964,6 +436169,7 @@ namespace: molecular_function def: "Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate." [EC:6.3.2.11, GOC:pz] xref: EC:6.3.2.11 xref: MetaCyc:RXN-11222 +xref: RHEA:59568 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] @@ -439061,6 +436267,7 @@ namespace: molecular_function def: "Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine <=> gibberellin A9 methyl ester + S-adenosyl-L-homocysteine." [EC:2.1.1.275, GOC:pz] xref: EC:2.1.1.275 xref: MetaCyc:RXN-11358 +xref: RHEA:36119 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -439138,6 +436345,7 @@ namespace: molecular_function def: "Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O <=> 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium." [EC:3.5.4.32, GOC:pz] xref: EC:3.5.4.32 xref: MetaCyc:RXN-11455 +xref: RHEA:32067 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] @@ -439188,7 +436396,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102134 name: (22S)-22-hydroxy-campesterol C-23 hydroxylase activity namespace: molecular_function -def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O." [EC:1.14.13.-, GOC:pz] +def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O." [GOC:pz] xref: MetaCyc:RXN-11529 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -439196,7 +436404,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102135 name: (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity namespace: molecular_function -def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O." [EC:1.14.13.-, GOC:pz] +def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O." [GOC:pz] xref: MetaCyc:RXN-11530 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -439264,6 +436472,7 @@ name: carboxynorspermidine dehydrogenase I activity namespace: molecular_function def: "Catalysis of the reaction: carboxynorspermidine + NADP + H2O <=> L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+." [EC:1.5.1.43, GOC:pz] xref: MetaCyc:RXN-11565 +xref: RHEA:34115 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] @@ -439272,6 +436481,7 @@ name: carboxyspermidine dehydrogenase II activity namespace: molecular_function def: "Catalysis of the reaction: carboxyspermidine + H2O + NADP <=> L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+." [EC:1.5.1.43, GOC:pz] xref: MetaCyc:RXN-11566 +xref: RHEA:34111 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] @@ -439290,6 +436500,7 @@ name: tricetin O-methytransferase activity namespace: molecular_function def: "Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-11582 +xref: RHEA:27493 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -439298,6 +436509,7 @@ name: 3'-O-methyltricetin O methyl transferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin." [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-11583 +xref: RHEA:27497 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -439316,6 +436528,7 @@ namespace: molecular_function def: "Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O <=> (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide." [EC:1.8.3.6, GOC:pz] xref: EC:1.8.3.6 xref: MetaCyc:RXN-11623 +xref: RHEA:30231 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] @@ -439373,7 +436586,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups id: GO:0102157 name: (R)-sulfopropanediol 2-dehydrogenase activity namespace: molecular_function -def: "Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+." [EC:1.1.1.-, GOC:pz] +def: "Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+." [GOC:pz, PMID:20150239] xref: MetaCyc:RXN-11729 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -439414,6 +436627,7 @@ namespace: molecular_function def: "Catalysis of the reaction: copal-8-ol diphosphate <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O." [EC:4.2.1.133, GOC:pz] xref: EC:4.2.1.133 xref: MetaCyc:RXN-11772 +xref: RHEA:32703 is_a: GO:0016836 ! hydro-lyase activity [Term] @@ -439480,6 +436694,7 @@ name: 5-methyl-phenazine-1-carboxylate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-11897 +xref: RHEA:49112 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -439488,6 +436703,7 @@ name: pyocyanin hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ <=> pyocyanin + NAD + carbon dioxide + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11898 +xref: RHEA:48976 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439506,6 +436722,7 @@ name: DMNT synthase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 <=> (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11911 +xref: RHEA:55424 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439514,6 +436731,7 @@ name: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-2 namespace: molecular_function def: "Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11925 +xref: RHEA:58860 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439522,6 +436740,7 @@ name: 24-methylenecycloartanol 4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11926 +xref: RHEA:58836 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439530,6 +436749,7 @@ name: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)- namespace: molecular_function def: "Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11927 +xref: RHEA:58864 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439538,6 +436758,7 @@ name: 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD <=> cycloeucalenone + NADH + carbon dioxide." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-11928 +xref: RHEA:59016 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -439554,6 +436775,7 @@ name: 24-methylenelophenol methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11930 +xref: RHEA:58872 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439562,6 +436784,7 @@ name: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH <=> 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11932 +xref: RHEA:58880 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439570,6 +436793,7 @@ name: 24-ethylidenelophenol 4alpha-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11935 +xref: RHEA:59032 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439578,6 +436802,7 @@ name: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase acti namespace: molecular_function def: "Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11936 +xref: RHEA:59036 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439586,6 +436811,7 @@ name: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-11937 +xref: RHEA:59040 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -439758,7 +436984,7 @@ is_a: GO:0008081 ! phosphoric diester hydrolase activity id: GO:0102201 name: (+)-2-epi-prezizaene synthase activity namespace: molecular_function -def: "Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +def: "Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid." [GOC:pz, PMID:20175559, PMID:20201526] xref: MetaCyc:RXN-12117 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates @@ -439807,6 +437033,7 @@ name: 2-polyprenyl-6-hydroxyphenol methylase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol <=> S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol." [EC:2.1.1.222, GOC:pz] xref: MetaCyc:RXN-12160 +xref: RHEA:31411 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -439872,6 +437099,7 @@ name: thiocyanate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine <=> methyl thiocyanate + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-12189 +xref: RHEA:28014 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -439936,6 +437164,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD <=> 4,4'-diapolycopene + 4 FADH2." [EC:1.3.8.2, GOC:pz] xref: EC:1.3.8.2 xref: MetaCyc:RXN-12224 +xref: RHEA:31391 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] @@ -439944,6 +437173,7 @@ name: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epime namespace: molecular_function def: "Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+." [EC:3.2.1.-, GOC:pz] xref: MetaCyc:RXN-12236 +xref: RHEA:46316 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -439952,6 +437182,7 @@ name: 4,4'-diaponeurosporene desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4'-diaponeurosporene + FAD + H+ <=> 4,4'-diapolycopene + FADH2." [EC:1.3.8.-, GOC:pz] xref: MetaCyc:RXN-12258 +xref: RHEA:31407 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] @@ -440074,6 +437305,7 @@ namespace: molecular_function def: "Catalysis of the reaction: aminodeoxyfutalosinate + H2O <=> dehypoxanthine futalosine + adenine." [EC:3.2.2.30, GOC:pz] xref: EC:3.2.2.30 xref: MetaCyc:RXN-12346 +xref: RHEA:33079 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] @@ -440176,7 +437408,7 @@ is_a: GO:0052689 ! carboxylic ester hydrolase activity id: GO:0102258 name: 1,3-diacylglycerol acylhydrolase activity namespace: molecular_function -def: "Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid." [EC:3.1.1.-, GOC:pz] +def: "Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid." [GOC:pz, PMID:21477884] xref: MetaCyc:RXN-12433 is_a: GO:0052689 ! carboxylic ester hydrolase activity @@ -440184,7 +437416,7 @@ is_a: GO:0052689 ! carboxylic ester hydrolase activity id: GO:0102259 name: 1,2-diacylglycerol acylhydrolase activity namespace: molecular_function -def: "Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid." [EC:3.1.1.-, GOC:pz] +def: "Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid." [GOC:pz, PMID:1477884] xref: MetaCyc:RXN-12434 is_a: GO:0052689 ! carboxylic ester hydrolase activity @@ -440195,6 +437427,7 @@ namespace: molecular_function def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-ol + 2 NADP + H2O <=> germacra-1(10),4,11(13)-trien-12-oate + 2 NADPH + 3 H+." [EC:1.1.1.314, GOC:pz] xref: EC:1.1.1.314 xref: MetaCyc:RXN-12449 +xref: RHEA:30667 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -440400,6 +437633,7 @@ namespace: molecular_function def: "Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ <=> 11-oxo-beta-amyrin + 3 H2O + 2 NADP." [EC:1.14.14.152, GOC:pz] xref: EC:1.14.14.152 xref: MetaCyc:RXN-12680 +xref: RHEA:31711 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -440409,6 +437643,7 @@ namespace: molecular_function def: "Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ <=> 11alpha-hydroxy-beta-amyrin + H2O + NADP." [EC:1.14.14.152, GOC:pz] xref: EC:1.14.14.152 xref: MetaCyc:RXN-12681 +xref: RHEA:31715 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -440418,6 +437653,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP." [EC:1.14.14.152, GOC:pz] xref: EC:1.14.14.152 xref: MetaCyc:RXN-12682 +xref: RHEA:31719 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -440444,6 +437680,7 @@ namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+." [EC:1.1.1.145, GOC:pz] xref: EC:1.1.1.145 xref: MetaCyc:RXN-12693 +xref: RHEA:43932 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -440487,6 +437724,7 @@ namespace: molecular_function def: "Catalysis of the reaction: alpha-linolenate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate." [EC:1.13.11.61, GOC:pz] xref: EC:1.13.11.61 xref: MetaCyc:RXN-12759 +xref: RHEA:31687 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] @@ -440544,6 +437782,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphoric acid." [EC:3.1.7.10, GOC:pz] xref: EC:3.1.7.10 xref: MetaCyc:RXN-12892 +xref: RHEA:32075 is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] @@ -440608,6 +437847,7 @@ name: 4-coumaroyl 2'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN-12963 +xref: RHEA:57868 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] @@ -440672,25 +437912,27 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102321 name: 2,2'-hydroxybiphenyl monooxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD." [EC:1.14.13.44, GOC:pz] +def: "Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD." [GOC:pz] xref: EC:1.14.13.44 -xref: MetaCyc:RXN-13150 +xref: MetaCyc:MONOMER-17239 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102322 name: 2-propylphenol monooxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD." [EC:1.14.13.-, GOC:pz] +def: "Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD." [GOC:pz, RHEA:63524] xref: MetaCyc:RXN-13151 +xref: RHEA:63524 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0102323 name: 2-isopropylphenol monooxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD." [EC:1.14.13.-, GOC:pz] +def: "Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD." [GOC:pz, RHEA:63520] xref: MetaCyc:RXN-13152 +xref: RHEA:63520 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -440705,8 +437947,9 @@ is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ke id: GO:0102325 name: 2,2',3-trihydroxybiphenyl monooxygenase activity namespace: molecular_function -def: "Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O." [EC:1.14.13.-, GOC:pz] +def: "Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O." [GOC:pz, RHEA:63516] xref: MetaCyc:RXN-13169 +xref: RHEA:63516 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -440780,6 +438023,7 @@ namespace: molecular_function def: "Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP." [EC:2.7.8.36, GOC:pz] xref: EC:2.7.8.36 xref: MetaCyc:RXN-13269 +xref: RHEA:34515 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] @@ -440929,6 +438173,7 @@ namespace: molecular_function def: "Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine." [EC:2.6.1.96, GOC:pz] xref: EC:2.6.1.96 xref: MetaCyc:RXN-13328 +xref: RHEA:32267 is_a: GO:0008483 ! transaminase activity [Term] @@ -440955,6 +438200,7 @@ name: 11-cis-retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-13363 +xref: RHEA:54912 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -441238,6 +438484,7 @@ namespace: molecular_function def: "Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol." [EC:1.3.1.94, GOC:pz] xref: EC:1.3.1.94 xref: MetaCyc:RXN-13604 +xref: RHEA:34279 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -441349,8 +438596,9 @@ is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds id: GO:0102405 name: (+)-taxifolin 5'-hydroxylase activity namespace: molecular_function -def: "Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O." [EC:1.14.13.-, GOC:pz] +def: "Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O." [GOC:pz] xref: MetaCyc:RXN-13718 +xref: RHEA:61116 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -441360,6 +438608,7 @@ namespace: molecular_function def: "Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate <=> coenzyme A + 16-sinapoyloxypalmitate." [EC:2.3.1.188, GOC:pz] xref: EC:2.3.1.188 xref: MetaCyc:RXN-13728 +xref: RHEA:26470 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -441467,6 +438716,7 @@ namespace: molecular_function def: "Catalysis of the reaction: omega-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-omega-hydroxy-C22:0-LPA." [EC:2.3.1.198, GOC:pz] xref: EC:2.3.1.198 xref: MetaCyc:RXN-13803 +xref: RHEA:33559 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -441498,7 +438748,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups id: GO:0102423 name: (+)-sesaminol 2-O-glucosyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +def: "Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+." [GOC:pz, PMID:18248594, PMID:19561332] xref: MetaCyc:RXN-13818 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -441557,6 +438807,7 @@ name: alpha-linolenate Delta5 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-linolenate + O2 + a reduced electron acceptor = coniferonate + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-13857 +xref: RHEA:38039 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] @@ -441565,6 +438816,7 @@ name: linoleate Delta5 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 + a reduced electron acceptor = pinolenate + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-13858 +xref: RHEA:46236 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] @@ -441776,6 +439028,7 @@ namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate." [EC:2.4.1.300, GOC:pz] xref: EC:2.4.1.300 xref: MetaCyc:RXN-13969 +xref: RHEA:35431 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -441877,6 +439130,7 @@ name: naringenin 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-naringenin + NADPH + O2 <=> 2-hydroxynaringenin + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14069 +xref: RHEA:57588 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -441901,6 +439155,7 @@ name: eriodictyol 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ <=> 2-hydroxyeriodictyol + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14077 +xref: RHEA:57596 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -441933,6 +439188,7 @@ name: pinocembrin 2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ <=> 2,5,7-trihydroxyflavanone + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-14083 +xref: RHEA:57592 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -442279,7 +439535,8 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102518 name: (11Z)-eicosenoate 14-hydroxylase activity namespace: molecular_function -def: "Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O." [EC:1.14.13.-, GOC:pz] +def: "Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O." [EC:1.14.18.4, GOC:pz, PMID:8784737, PMID:9680976] +xref: EC:1.14.18.4 xref: MetaCyc:RXN-14488 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -442519,6 +439776,7 @@ name: mannosylglycerate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate." [EC:3.3.2.-, GOC:pz] xref: MetaCyc:RXN-14900 +xref: RHEA:58456 is_a: GO:0016803 ! ether hydrolase activity [Term] @@ -442527,6 +439785,7 @@ name: glucosylglycerate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate <=> alpha-D-glucose + D-glycerate." [EC:3.3.2.-, GOC:pz] xref: MetaCyc:RXN-14901 +xref: RHEA:32059 is_a: GO:0016803 ! ether hydrolase activity [Term] @@ -442545,6 +439804,7 @@ namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol <=> S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+." [EC:2.1.1.295, GOC:pz] xref: EC:2.1.1.295 xref: MetaCyc:RXN-14917 +xref: RHEA:38007 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -442650,6 +439910,7 @@ name: hydroxyproline O-arbinofuranose transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline." [EC:2.4.2.-, GOC:pz] xref: MetaCyc:RXN-15011 +xref: RHEA:49472 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] @@ -442666,6 +439927,7 @@ name: aurachin C epoxide hydrolase/isomerase activity namespace: molecular_function def: "Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P)." [EC:3.3.2.-, GOC:pz] xref: MetaCyc:RXN-15030 +xref: RHEA:48728 is_a: GO:0016803 ! ether hydrolase activity [Term] @@ -442726,6 +439988,7 @@ name: N-glutamylanilide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+." [EC:3.5.1.-, GOC:pz] xref: MetaCyc:RXN-15251 +xref: RHEA:50684 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -442778,6 +440041,7 @@ namespace: molecular_function def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP." [EC:2.4.2.51, GOC:pz] xref: EC:2.4.2.51 xref: MetaCyc:RXN-15326 +xref: RHEA:35443 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] @@ -442953,6 +440217,7 @@ name: cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 16beta-hydroxy-beta-amyrin + H2O + NAD(P)." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15385 +xref: RHEA:55440 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -442987,6 +440252,7 @@ name: cyclooctat-9-en-5,7-diol C18-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ <=> cyclooctatin + H2O + NADP." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15430 +xref: RHEA:56824 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -442995,6 +440261,7 @@ name: octat-9-en-7-ol 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ <=> cyclooctat-9-en-5,7-diol + H2O + NADP." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15431 +xref: RHEA:56820 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -443026,7 +440293,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102610 name: (+)-secoisolariciresinol glucosyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +def: "Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+." [GOC:pz, PMID:24678929] xref: MetaCyc:RXN-15442 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -443034,7 +440301,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups id: GO:0102611 name: (+)-secoisolariciresinol monoglucoside glucosyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +def: "Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+." [GOC:pz, PMID:24678929] xref: MetaCyc:RXN-15443 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -443052,6 +440319,7 @@ name: trimethyluric acid monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15454 +xref: RHEA:48992 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -443068,6 +440336,7 @@ name: ent-cassadiene-C2-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ <=> 2alpha-hydroxy-ent-cassadiene + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-15462 +xref: RHEA:55484 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -443202,7 +440471,8 @@ is_a: GO:0008168 ! methyltransferase activity id: GO:0102632 name: (S)-nandinine synthase activity namespace: molecular_function -def: "Catalysis of the reaction: (S)-scoulerine + NADPH + H+ + O2 <=> (S)-nandinine + NADP + 2 H2O." [GOC:pz] +def: "Catalysis of the reaction: (S)-scoulerine + NADPH + H+ + O2 <=> (S)-nandinine + NADP + 2 H2O." [GOC:pz, PMID:17250743, PMID:21094631, RHEA:50364] +xref: EC:1.14.19.73 xref: MetaCyc:RXN-15538 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated @@ -443218,7 +440488,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102634 name: 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity namespace: molecular_function -def: "Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+." [EC:1.13.12.-, GOC:pz] +def: "Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+." [GOC:pz, PMID:15701630] xref: MetaCyc:RXN-15586 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) @@ -443228,6 +440498,7 @@ name: 11-deoxycorticosterone reductase activity namespace: molecular_function def: "Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ <=> 4-pregnen-20,21-diol-3-one + NAD." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-15607 +xref: RHEA:47716 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -443276,7 +440547,7 @@ is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorp id: GO:0102641 name: (R)-lactaldehyde dehydrogenase activity namespace: molecular_function -def: "Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+." [EC:1.1.1.-, GOC:pz] +def: "Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+." [GOC:pz] xref: MetaCyc:RXN-15743 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -443388,7 +440659,8 @@ is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidat id: GO:0102657 name: 1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity namespace: molecular_function -def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:15579662] +xref: EC:1.14.19.42 xref: MetaCyc:RXN-1728 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water @@ -443433,6 +440705,7 @@ name: malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) <=> acetyl-CoA(4-) + carbon dioxide + NADH(2-)." [EC:1.2.1.-, GOC:pz] xref: MetaCyc:RXN-2902 +xref: RHEA:22992 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -443573,7 +440846,7 @@ is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, id: GO:0102679 name: (5alpha)-campestan-3-one hydroxylase activity namespace: molecular_function -def: "Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP." [EC:1.14.13.-, GOC:pz] +def: "Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP." [GOC:pz, PMID:10377996] xref: MetaCyc:RXN-4230 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -443599,6 +440872,7 @@ name: N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase ac namespace: molecular_function def: "Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O <=> N(6)-dimethylallyladenine + D-ribofuranose 5-phosphate." [EC:3.2.2.-, GOC:pz] xref: MetaCyc:RXN-4313 +xref: RHEA:48560 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] @@ -443731,6 +441005,7 @@ name: 2-methylpropionitrile hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH <=> 2-hydroxy-2-methylpropanenitrile + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-5082 +xref: RHEA:51964 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -443776,6 +441051,7 @@ namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol <=> H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol." [EC:2.4.1.257, GOC:pz] xref: EC:2.4.1.257 xref: MetaCyc:RXN-5463 +xref: RHEA:29519 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -443784,6 +441060,7 @@ name: serine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + L-serine <=> ethanolaminium(1+) + carbon dioxide." [EC:4.1.1.-, GOC:pz] xref: MetaCyc:RXN-5641 +xref: RHEA:45824 is_a: GO:0016831 ! carboxy-lyase activity [Term] @@ -443915,6 +441192,7 @@ namespace: molecular_function def: "Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A." [EC:2.3.1.224, GOC:pz] xref: EC:2.3.1.224 xref: MetaCyc:RXN-6762 +xref: RHEA:36147 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -443966,6 +441244,7 @@ namespace: molecular_function def: "Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose." [EC:3.2.1.182, GOC:pz] xref: EC:3.2.1.182 xref: MetaCyc:RXN-7082 +xref: RHEA:33975 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] @@ -443982,6 +441261,7 @@ name: campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH." [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-711 +xref: RHEA:54416 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -444055,7 +441335,7 @@ is_a: GO:0016747 ! transferase activity, transferring acyl groups other than ami id: GO:0102738 name: (gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function -def: "Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz] +def: "Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate." [GOC:pz] xref: MetaCyc:RXN-7589 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity @@ -444063,7 +441343,7 @@ is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity id: GO:0102739 name: (gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function -def: "Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide." [EC:1.14.11.-, GOC:pz] +def: "Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide." [GOC:pz] xref: MetaCyc:RXN-7591 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity @@ -444074,6 +441354,7 @@ namespace: molecular_function def: "Catalysis of the reaction: theobromine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine." [EC:2.1.1.160, GOC:pz] xref: EC:2.1.1.160 xref: MetaCyc:RXN-7599 +xref: RHEA:20944 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -444166,6 +441447,7 @@ namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+." [EC:2.4.1.186, GOC:pz] xref: EC:2.4.1.186 xref: MetaCyc:RXN-7667 +xref: RHEA:56560 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -444217,6 +441499,7 @@ name: NADPH phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate." [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN-7703 +xref: RHEA:60664 is_a: GO:0016791 ! phosphatase activity [Term] @@ -444226,6 +441509,7 @@ namespace: molecular_function def: "Catalysis of the reaction: NADP(3-) + a very-long-chain 2,3,4-saturated fatty acyl CoA <=> NADPH(4-) + H+ + a very-long-chain trans-2,3-dehydroacyl-CoA." [EC:1.3.1.93, GOC:pz] xref: EC:1.3.1.93 xref: MetaCyc:RXN-7711 +xref: RHEA:14473 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -444250,6 +441534,7 @@ name: eriodictyol 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + homoeriodictyol + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-7753 +xref: RHEA:60948 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -444266,6 +441551,7 @@ name: phytyl-P kinase activity namespace: molecular_function def: "Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate <=> (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate." [EC:2.7.4.-, GOC:pz] xref: MetaCyc:RXN-7763 +xref: RHEA:38099 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] @@ -444301,6 +441587,7 @@ namespace: molecular_function def: "Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine." [EC:2.1.1.231, GOC:pz] xref: EC:2.1.1.231 xref: MetaCyc:RXN-7777 +xref: RHEA:31743 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -444334,6 +441621,7 @@ name: sphingolipid very long chain fatty acid alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-7796 +xref: RHEA:46512 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -444461,6 +441749,7 @@ namespace: molecular_function def: "Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin." [EC:1.14.19.2, GOC:pz] xref: EC:1.14.19.2 xref: MetaCyc:RXN-7903 +xref: RHEA:11776 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] @@ -444629,6 +441918,7 @@ namespace: molecular_function def: "Catalysis of the reaction: codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + carbon dioxide." [EC:1.14.11.32, GOC:pz] xref: EC:1.14.11.32 xref: MetaCyc:RXN-8152 +xref: RHEA:27413 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] @@ -444669,6 +441959,7 @@ name: glutarate-semialdehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+." [EC:1.2.1.-, GOC:pz] xref: MetaCyc:RXN-8182 +xref: RHEA:57832 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -444721,6 +442012,7 @@ namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside <=> H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP." [EC:2.4.1.298, GOC:pz] xref: EC:2.4.1.298 xref: MetaCyc:RXN-8234 +xref: RHEA:35423 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -444770,6 +442062,7 @@ namespace: molecular_function def: "Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine." [EC:2.1.1.42, GOC:pz] xref: EC:2.1.1.42 xref: MetaCyc:RXN-8262 +xref: RHEA:55332 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -444786,6 +442079,7 @@ name: UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose <=> H+ + quercetin 3-O-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-8267 +xref: RHEA:61160 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -444864,7 +442158,8 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups id: GO:0102834 name: 1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity namespace: molecular_function -def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918, PMID:8066133] +xref: EC:1.14.19.23 xref: MetaCyc:RXN-8294 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water @@ -445122,6 +442417,7 @@ name: di-homo-gamma-linolenate Delta5 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor <=> arachidonate + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-8346 +xref: RHEA:46260 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] @@ -445131,6 +442427,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O." [EC:2.8.1.9, GOC:pz] xref: EC:2.8.1.9 xref: MetaCyc:RXN-8351 +xref: RHEA:42636 is_a: GO:0016783 ! sulfurtransferase activity [Term] @@ -445161,7 +442458,8 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups id: GO:0102871 name: 1-16:0-2-18:1-phosphatidylcholine desaturase activity namespace: molecular_function -def: "Catalysis of the reaction: 1-16:0-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-palmitoyl-2-linoleoyl-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +def: "Catalysis of the reaction: 1-16:0-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-palmitoyl-2-linoleoyl-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:475773] +xref: EC:1.14.19.22 xref: MetaCyc:RXN-8360 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water @@ -445169,7 +442467,8 @@ is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidat id: GO:0102872 name: 1-16:0-2-18:2-phosphatidylcholine desaturase activity namespace: molecular_function -def: "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +def: "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:15538555, PMID:8102138] +xref: EC:1.14.19.25 xref: MetaCyc:RXN-8361 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water @@ -445177,7 +442476,8 @@ is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidat id: GO:0102873 name: 1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity namespace: molecular_function -def: "Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +def: "Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918, PMID:8066133] +xref: EC:1.14.19.23 xref: MetaCyc:RXN-8363 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water @@ -445185,7 +442485,8 @@ is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidat id: GO:0102874 name: 1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity namespace: molecular_function -def: "Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +def: "Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:17064923] +xref: EC:1.14.19.35 xref: MetaCyc:RXN-8365 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water @@ -445249,7 +442550,7 @@ is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates id: GO:0102881 name: (+)-beta-barbatene synthase activity namespace: molecular_function -def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid." [GOC:pz, PMID:15918888, PMID:16297850] xref: MetaCyc:RXN-8421 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates @@ -445342,6 +442643,7 @@ namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone <=> H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP." [EC:2.4.1.286, GOC:pz] xref: EC:2.4.1.286 xref: MetaCyc:RXN-8455 +xref: RHEA:34295 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -445375,6 +442677,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 9(S)-HPODE <=> colneleate + H2O." [EC:4.2.1.121, GOC:pz] xref: EC:4.2.1.121 xref: MetaCyc:RXN-8496 +xref: RHEA:28174 is_a: GO:0016836 ! hydro-lyase activity [Term] @@ -445383,6 +442686,7 @@ name: colnelenate synthase activity namespace: molecular_function def: "Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate <=> colnelenate + H2O." [EC:4.2.1.121, GOC:pz] xref: MetaCyc:RXN-8498 +xref: RHEA:28178 is_a: GO:0016836 ! hydro-lyase activity [Term] @@ -445391,6 +442695,7 @@ name: abietadienal hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: abietal + NADPH + O2 <=> abietate + NADP + H2O." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-8510 +xref: RHEA:56928 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -445450,6 +442755,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid." [EC:4.2.3.60, GOC:pz] xref: EC:4.2.3.60 xref: MetaCyc:RXN-8561 +xref: RHEA:28302 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] @@ -445469,6 +442775,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (-)-7-epi-alpha-selinene + diphosphoric acid." [EC:4.2.3.86, GOC:pz] xref: EC:4.2.3.86 xref: MetaCyc:RXN-8609 +xref: RHEA:30383 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] @@ -445499,7 +442806,7 @@ is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related subs id: GO:0102911 name: (-)-secoisolariciresinol dehydrogenase activity namespace: molecular_function -def: "Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH." [EC:1.1.1.-, GOC:pz] +def: "Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH." [EC:1.1.1.331, GOC:pz] xref: MetaCyc:RXN-8680 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -445507,7 +442814,7 @@ is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, id: GO:0102912 name: (-)-lactol dehydrogenase activity namespace: molecular_function -def: "Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH." [EC:1.1.1.-, GOC:pz] +def: "Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH." [EC:1.1.1.331, GOC:pz] xref: MetaCyc:RXN-8681 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor @@ -445517,6 +442824,7 @@ name: 3-aminomethylindole N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-8686 +xref: RHEA:52268 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -445525,6 +442833,7 @@ name: N-methyl-3-aminomethylindole N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-8687 +xref: RHEA:52272 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -445598,6 +442907,7 @@ name: phenylpropanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A." [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-8857 +xref: RHEA:42488 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -445606,6 +442916,7 @@ name: 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = H+ + paclitaxel + coenzyme A." [EC:2.3.1.-, GOC:pz] xref: MetaCyc:RXN-8859 +xref: RHEA:33687 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -445670,7 +442981,7 @@ is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than id: GO:0102931 name: (Z,E)-alpha- farnesene synthase activity namespace: molecular_function -def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid." [GOC:pz, PMID:17140613] xref: MetaCyc:RXN-8931 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates @@ -445806,7 +443117,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups id: GO:0102947 name: (+)-delta-cadinene-8-hydroxylase activity namespace: molecular_function -def: "Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O." [EC:1.14.13.-, GOC:pz] +def: "Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O." [GOC:pz] xref: MetaCyc:RXN-9045 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen @@ -445822,7 +443133,7 @@ is_a: GO:0016758 ! transferase activity, transferring hexosyl groups id: GO:0102949 name: 1,2-rhamnosyltransferase activity namespace: molecular_function -def: "Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor." [EC:2.4.1.-, GOC:pz] +def: "Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor." [GOC:pz, PMID:15220389] xref: MetaCyc:RXN-9082 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups @@ -445848,6 +443159,7 @@ name: UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP." [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-91 +xref: RHEA:57708 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -445883,6 +443195,7 @@ name: UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP." [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN-92 +xref: RHEA:57712 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -445901,6 +443214,7 @@ name: 4,4'-diapophytofluene desaturase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-4,4'-diapophytofluene + FAD + H+ = all-trans-4,4'-diapo-zeta-carotene + FADH2." [EC:1.3.8.-, GOC:pz] xref: MetaCyc:RXN-9304 +xref: RHEA:31399 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] @@ -445909,14 +443223,17 @@ name: 4,4'-diapo-zeta-carotene desaturase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-4,4'-diapo-zeta-carotene + FAD + H+ = 4,4'-diaponeurosporene + FADH2." [EC:1.3.8.-, GOC:pz] xref: MetaCyc:RXN-9305 +xref: RHEA:31403 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0102963 name: (S)-corytuberine synthase activity namespace: molecular_function -def: "Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O." [EC:1.14.21.-, GOC:pz] +def: "Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O." [EC:1.14.19.51, GOC:pz, PMID:18230623] +xref: EC:1.14.19.51 xref: MetaCyc:RXN-9314 +xref: RHEA:51540 is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated [Term] @@ -445925,6 +443242,7 @@ name: S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine <=> H+ + magnoflorine + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-9315 +xref: RHEA:51524 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -445934,6 +443252,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol." [EC:1.2.1.84, GOC:pz] xref: EC:1.2.1.84 xref: MetaCyc:RXN-9344 +xref: RHEA:52716 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] @@ -445951,6 +443270,7 @@ name: 10-hydroxygeraniol oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP <=> (6E)-8-hydroxygeranial + NADPH + H+." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-9367 +xref: RHEA:32607 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -445959,6 +443279,7 @@ name: 10-hydroxygeranial oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP <=> (6E)-8-oxogeranial + NADPH + H+." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-9369 +xref: RHEA:32611 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -445967,6 +443288,7 @@ name: 10-oxogeraniol oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: (6E)-8-oxogeraniol + NADP <=> (6E)-8-oxogeranial + NADPH + H+." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-9370 +xref: RHEA:32615 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -446005,6 +443327,7 @@ def: "Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier synonym: "norsolorinic acid synthase" EXACT [] xref: EC:2.3.1.221 xref: MetaCyc:RXN-9479 +xref: RHEA:35179 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -446044,6 +443367,7 @@ namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN." [EC:1.14.14.10, GOC:pz] xref: EC:1.14.14.10 xref: MetaCyc:RXN-9508 +xref: RHEA:31359 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] @@ -446062,6 +443386,7 @@ name: homofuraneol oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: homofuraneol + NADP <=> (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+." [EC:1.3.1.-, GOC:pz] xref: MetaCyc:RXN-9564 +xref: RHEA:53944 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] @@ -446086,6 +443411,7 @@ name: UDP-3-dehydro-alpha-D-glucose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-alpha-D-glucose + NAD <=> H+ + UDP-3-keto-alpha-D-glucose + NADH." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN-9578 +xref: RHEA:35755 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -446114,6 +443440,7 @@ namespace: molecular_function def: "Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor <=> linoleoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.6, GOC:pz] xref: EC:1.14.19.6 xref: MetaCyc:RXN-9601 +xref: RHEA:25856 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] @@ -446132,6 +443459,7 @@ name: palmitoleic acid delta 12 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-9616 +xref: RHEA:45096 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] @@ -446140,6 +443468,7 @@ name: 9,12-cis-hexadecadienoic acid delta 15 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor <=> 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-9617 +xref: RHEA:46232 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] @@ -446156,6 +443485,7 @@ name: 5-n-alk(en)ylresorcinol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] xref: MetaCyc:RXN-9619 +xref: RHEA:26325 is_a: GO:0008168 ! methyltransferase activity [Term] @@ -446165,6 +443495,7 @@ namespace: molecular_function def: "Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A." [EC:3.1.2.2, GOC:pz] xref: EC:3.1.2.2 xref: MetaCyc:RXN-9626 +xref: RHEA:40119 is_a: GO:0016790 ! thiolester hydrolase activity [Term] @@ -446173,6 +443504,7 @@ name: 2-methylbutyronitrile hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 <=> H2O + NADP + 2-hydroxy-2-methylbutyronitrile." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-9642 +xref: RHEA:51948 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -446181,6 +443513,7 @@ name: linolenate Delta15 desaturase activity namespace: molecular_function def: "Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] xref: MetaCyc:RXN-9667 +xref: RHEA:46408 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] @@ -446242,6 +443575,7 @@ name: dimethylsulfoxide oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ <=> sulfonyldimethane + H2O + NADP." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXN-9767 +xref: RHEA:57956 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -446353,6 +443687,7 @@ namespace: molecular_function def: "Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate." [EC:2.4.2.43, GOC:pz] xref: EC:2.4.2.43 xref: MetaCyc:RXN0-2001 +xref: RHEA:35371 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] @@ -446378,6 +443713,7 @@ name: ITPase activity namespace: molecular_function def: "Catalysis of the reaction: ITP + H2O <=> H+ + IDP + hydrogenphosphate." [EC:3.6.1.-, GOC:pz] xref: MetaCyc:RXN0-5073 +xref: RHEA:28330 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] @@ -446395,6 +443731,7 @@ name: fructose-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O <=> beta-D-fructofuranose + hydrogenphosphate." [EC:3.1.3.-, GOC:pz] xref: MetaCyc:RXN0-5186 +xref: RHEA:35603 is_a: GO:0016791 ! phosphatase activity [Term] @@ -446419,6 +443756,7 @@ name: ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity namespace: molecular_function def: "Catalysis of the reaction: H+ + methylglyoxal + NADH = hydroxyacetone + NAD." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN0-5213 +xref: RHEA:35615 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -446427,6 +443765,7 @@ name: L-Ala-D/L-Glu epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate." [EC:5.1.1.-, GOC:pz] xref: MetaCyc:RXN0-5228 +xref: RHEA:28394 is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] @@ -446435,6 +443774,7 @@ name: tartronate semialdehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + NAD <=> H+ + 2-hydroxy-3-oxopropanoate + NADH." [EC:1.1.1.-, GOC:pz] xref: MetaCyc:RXN0-5289 +xref: RHEA:18845 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] @@ -446476,6 +443816,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor." [EC:2.8.4.4, GOC:pz] xref: EC:2.8.4.4 xref: MetaCyc:RXN0-6366 +xref: RHEA:37087 is_a: GO:0035596 ! methylthiotransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein @@ -446501,6 +443842,7 @@ name: 4-hydroxy-L-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine." [EC:4.1.2.-, GOC:pz] xref: MetaCyc:RXN0-6563 +xref: RHEA:28779 is_a: GO:0016832 ! aldehyde-lyase activity [Term] @@ -446528,6 +443870,7 @@ namespace: molecular_function def: "Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+." [EC:2.3.1.1, GOC:pz] xref: EC:2.3.1.1 xref: MetaCyc:RXN0-6948 +xref: RHEA:44144 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] @@ -446587,6 +443930,7 @@ namespace: molecular_function def: "Catalysis of the reaction: 1-ethyladenine + O2 + 2-oxoglutarate(2-) <=> adenine + carbon dioxide + acetaldehyde + succinate." [EC:1.14.11.33, GOC:pz] xref: EC:1.14.11.33 xref: MetaCyc:RXN0-986 +xref: RHEA:30299 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] @@ -446595,6 +443939,7 @@ name: gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberelli namespace: molecular_function def: "Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate <=> gibberellin A15 + carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN1F-162 +xref: RHEA:60776 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] @@ -446603,6 +443948,7 @@ name: gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O." [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN1F-163 +xref: RHEA:60780 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] @@ -446611,6 +443957,7 @@ name: gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate <=> gibberellin A44 diacid + carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz] xref: MetaCyc:RXN1F-167 +xref: RHEA:60800 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] @@ -446635,6 +443982,7 @@ name: UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose <=> H+ + kaempferol-3-rhamnoside + UDP(3-)." [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN1F-474 +xref: RHEA:61164 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -446675,6 +444023,7 @@ name: inositol phosphorylceramide mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + an inositol-phospho-alpha hydroxyphytoceramide = H+ + GDP + a mannosyl-inositol-phospho-alpha hydroxyphytoceramide." [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXN3O-663 +xref: RHEA:61496 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -446764,6 +444113,7 @@ name: quercetin 3-glucoside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose <=> quercetin-3-O-glucoside-7-O-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXNQT-4161 +xref: RHEA:61188 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -446772,6 +444122,7 @@ name: quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] xref: MetaCyc:RXNQT-4162 +xref: RHEA:61184 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] @@ -446780,6 +444131,7 @@ name: 2-(3'-methylthio)propylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-(3-methylthiopropyl)malate + coenzyme A." [EC:2.3.3.-, GOC:pz] xref: MetaCyc:RXNQT-4163 +xref: RHEA:25605 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] @@ -446788,6 +444140,7 @@ name: methylthiopropylmalate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) <=> 3-(3'-methylthio)propylmalate." [EC:5.4.4.-, GOC:pz] xref: MetaCyc:RXNQT-4164 +xref: RHEA:50644 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] @@ -446900,6 +444253,7 @@ name: CYP79F1 dihomomethionine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXNQT-4309 +xref: RHEA:32719 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -446908,6 +444262,7 @@ name: CYP79F1 trihomomethionine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime." [EC:1.14.13.-, GOC:pz] xref: MetaCyc:RXNQT-4310 +xref: RHEA:32723 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] @@ -447002,6 +444357,7 @@ namespace: molecular_function def: "Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine <=> D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine." [EC:2.7.1.69, GOC:pz] xref: EC:2.7.1.69 xref: MetaCyc:TRANS-RXN-167A +xref: RHEA:37359 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] @@ -447016,10 +444372,12 @@ is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity id: GO:0103116 name: ATPase-coupled alpha-D-galactofuranose transporter activity namespace: molecular_function -def: "Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+." [GOC:pz] +def: "Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+." [GOC:pz, PMID:19744923, RHEA:61716] synonym: "alpha-D-galactofuranose transporter activity" EXACT [] synonym: "ATP-dependent alpha-D-galactofuranose transporter activity" EXACT [] +xref: EC:7.5.2.9 xref: MetaCyc:TRANS-RXN0-491 +xref: RHEA:61716 is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity [Term] @@ -447029,6 +444387,7 @@ namespace: molecular_function def: "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate." [EC:3.5.1.108, GOC:pz] xref: EC:3.5.1.108 xref: MetaCyc:UDPACYLGLCNACDEACETYL-RXN +xref: RHEA:25209 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] @@ -447148,12 +444507,13 @@ namespace: molecular_function alt_id: GO:0140362 def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location." [PMID:25736293, PMID:30840879] synonym: "BAR domain adaptor" NARROW [] -synonym: "cytoskeletal protein membrane adaptor" EXACT [] -synonym: "cytoskeletal protein membrane adaptor activity" EXACT [] -synonym: "cytoskeletal protein membrane anchor activity" EXACT [] -synonym: "cytoskeletal protein-membrane adaptor activity" EXACT [] +synonym: "cytoskeletal protein membrane adaptor" BROAD [] +synonym: "cytoskeletal protein membrane anchor activity" BROAD [] +synonym: "cytoskeletal protein membrane tether activity" BROAD [] +synonym: "cytoskeletal protein-membrane adaptor activity" BROAD [] synonym: "F-BAR domain adaptor" NARROW [] -synonym: "membrane-cytoskeletal protein anchor activity" EXACT [] +synonym: "membrane-cytoskeletal protein anchor activity" BROAD [] +synonym: "membrane-cytoskeletal protein tether activity" BROAD [] synonym: "microtubule cortical anchor activity" NARROW [] is_a: GO:0008093 ! cytoskeletal anchor activity is_a: GO:0043495 ! protein-membrane adaptor activity @@ -447179,6 +444539,7 @@ name: 2-oxoglutaramate amidase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutaramate + H(2)O = 2-oxoglutarate + NH(3)." [EC:3.5.1.111, PMID:21288482] xref: EC:3.5.1.111 +xref: RHEA:32963 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides created_by: hjd creation_date: 2017-04-25T14:10:02Z @@ -447189,6 +444550,7 @@ name: (4S)-4-hydroxy-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.42, GOC:hjd, PMID:1098660, PMID:1339418] xref: EC:4.1.3.42 +xref: RHEA:35639 is_a: GO:0016833 ! oxo-acid-lyase activity created_by: hjd creation_date: 2017-04-25T14:14:58Z @@ -447435,6 +444797,7 @@ xref: EC:5.4.99.42 xref: EC:5.4.99.44 xref: EC:5.4.99.45 xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN +xref: RHEA:22376 is_a: GO:0009982 ! pseudouridine synthase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA created_by: hjd @@ -447767,7 +445130,6 @@ name: regulation of cobalamin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [PMID:29056341] is_a: GO:0030656 ! regulation of vitamin metabolic process -is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009235 ! cobalamin metabolic process @@ -447848,6 +445210,7 @@ name: dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activ namespace: molecular_function def: "Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol." [GOC:ha, PMID:9597543] xref: EC:2.4.1.256 +xref: RHEA:29543 is_a: GO:0046527 ! glucosyltransferase activity created_by: hjd creation_date: 2017-11-28T19:16:37Z @@ -448095,6 +445458,7 @@ name: 2-keto-3-deoxy-L-rhamnonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde." [EC:4.1.2.53, GOC:imk, PMID:18754683] xref: EC:4.1.2.53 +xref: RHEA:25784 is_a: GO:0016832 ! aldehyde-lyase activity created_by: hjd creation_date: 2018-02-15T16:12:17Z @@ -448356,7 +445720,6 @@ name: positive regulation of cobalamin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341] is_a: GO:0046136 ! positive regulation of vitamin metabolic process -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:0106064 ! regulation of cobalamin metabolic process is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation @@ -448371,7 +445734,6 @@ name: negative regulation of cobalamin metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341] is_a: GO:0046137 ! negative regulation of vitamin metabolic process -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:0106064 ! regulation of cobalamin metabolic process is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process intersection_of: GO:0065007 ! biological regulation @@ -448551,6 +445913,7 @@ comment: The m(1)A modification at position 645 in the large rRNA is highly cons synonym: "25S rRNA (adenine(645)-N(1))-methyltransferase" EXACT [EC:2.1.1.287] synonym: "25S rRNA m(1)A(645) methyltransferase" EXACT [EC:2.1.1.287] xref: EC:2.1.1.287 +xref: RHEA:43792 is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity created_by: hjd creation_date: 2018-08-22T20:13:21Z @@ -448798,9 +446161,8 @@ name: spindle pole body-nuclear membrane anchor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body." [GOC:vw, PMID:9763447] synonym: "nuclear membrane-spindle pole body anchor activity" EXACT [] -synonym: "spindle pole body anchor" EXACT [] synonym: "spindle pole body nuclear membrane anchor activity" EXACT [] -is_a: GO:0043495 ! protein-membrane adaptor activity +is_a: GO:0140475 ! spindle pole body anchor activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19119 xsd:anyURI created_by: hjd creation_date: 2019-01-18T15:57:42Z @@ -449275,8 +446637,6 @@ name: pyocyanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrocyanin, an iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group." [PMID:28715477] synonym: "pyocyanin biosynthetic process" EXACT [] -is_a: GO:0009403 ! toxin biosynthetic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process @@ -449560,7 +446920,7 @@ creation_date: 2020-02-18T17:51:43Z id: GO:0106250 name: DNA-binding transcription repressor activity, RNA polymerase III-specific namespace: molecular_function -def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase III-transcribed gene to repress or decrease transcription." [GOC:vw, PMID:15590667, PMID:31833215] +def: "Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase III-transcribed gene to repress or decrease transcription." [GOC:txnOH-2018, PMID:15590667, PMID:31833215] is_a: GO:0001217 ! DNA-binding transcription repressor activity created_by: hjd creation_date: 2020-02-19T19:34:18Z @@ -449648,6 +447008,227 @@ is_a: GO:0044001 ! migration in host created_by: hjd creation_date: 2020-05-01T14:09:35Z +[Term] +id: GO:0106260 +name: double-stranded DNA bridging +namespace: molecular_function +def: "The binding activity of a molecule that interacts selectively and non-covalently with two or more regions of double-stranded DNA simultaneously. The binding may be inter- or intramolecular with respect to the DNA." [GOC:mah, PMID:30626735] +synonym: "dsDNA bridging" EXACT [] +is_a: GO:0003690 ! double-stranded DNA binding +created_by: hjd +creation_date: 2020-05-07T19:53:35Z + +[Term] +id: GO:0106261 +name: tRNA uridine(34) acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine." [PMID:25151136, PMID:30733442, RHEA:61020] +xref: RHEA:61020 +is_a: GO:0016407 ! acetyltransferase activity +created_by: hjd +creation_date: 2020-05-08T15:21:51Z + +[Term] +id: GO:0106262 +name: 1-acylglycerophosphoethanolamine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA." [PMID:18287005, RHEA:32995] +is_a: GO:0008374 ! O-acyltransferase activity +created_by: hjd +creation_date: 2020-05-18T15:09:57Z + +[Term] +id: GO:0106263 +name: 1-acylglycerophosphoserine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA." [PMID:18287005, RHEA:33191] +is_a: GO:0008374 ! O-acyltransferase activity +created_by: hjd +creation_date: 2020-05-18T15:12:42Z + +[Term] +id: GO:0106264 +name: protein serine kinase activity (using GTP as donor) +namespace: molecular_function +def: "Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]." [GOC:sp, PMID:32322062, Rhea:64020] +is_a: GO:0004672 ! protein kinase activity +created_by: hjd +creation_date: 2020-05-28T18:51:18Z + +[Term] +id: GO:0106265 +name: THPH synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA." [PMID:9446571] +synonym: "polyketide syntase" RELATED [] +is_a: GO:0003824 ! catalytic activity +created_by: hjd +creation_date: 2020-06-02T18:05:33Z + +[Term] +id: GO:0106266 +name: 3-chloro THPH synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O." [PMID:20231486] +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen +created_by: hjd +creation_date: 2020-06-02T18:13:44Z + +[Term] +id: GO:0106267 +name: 3,5 dichloro-THPH synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O." [PMID:20231486] +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen +created_by: hjd +creation_date: 2020-06-02T18:16:23Z + +[Term] +id: GO:0106268 +name: 3,5-dichloro-THPH methyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine." [PMID:20231486] +synonym: "DIF-1 syntase" RELATED [] +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +created_by: hjd +creation_date: 2020-06-02T18:25:03Z + +[Term] +id: GO:0106271 +name: D-arabinose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH." [RHEA:21892] +xref: EC:1.1.1.117 +xref: RHEA:21892 +is_a: GO:0045290 ! D-arabinose 1-dehydrogenase [NAD(P)+] activity +created_by: hjd +creation_date: 2020-06-23T18:47:25Z + +[Term] +id: GO:0106272 +name: protein localization to ERGIC +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059] +is_a: GO:0034067 ! protein localization to Golgi apparatus +created_by: hjd +creation_date: 2020-07-01T17:04:35Z + +[Term] +id: GO:0106273 +name: cytosol to ERGIC protein transport +namespace: biological_process +def: "The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059] +is_a: GO:0015031 ! protein transport +created_by: hjd +creation_date: 2020-07-01T17:28:07Z + +[Term] +id: GO:0106274 +name: NAD+-protein-arginine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [RHEA:19149] +xref: EC:2.4.2.31 +xref: RHEA:19149 +is_a: GO:0003956 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity +created_by: hjd +creation_date: 2020-07-02T01:37:02Z + +[Term] +id: GO:0106275 +name: NADP+-protein-arginine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [RHEA:54884] +xref: EC:2.4.2.31 +xref: RHEA:54884 +is_a: GO:0003956 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity +created_by: hjd +creation_date: 2020-07-02T01:39:04Z + +[Term] +id: GO:0106276 +name: biliberdin reductase NAD+ activity +namespace: molecular_function +def: "Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+." [RHEA:15797] +xref: EC:1.3.1.24 +xref: RHEA:15797 +is_a: GO:0004074 ! biliverdin reductase (NAD(P)+) activity +created_by: hjd +creation_date: 2020-07-02T01:48:07Z + +[Term] +id: GO:0106277 +name: biliverdin reductase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+." [RHEA:15793] +xref: EC:1.3.1.24 +xref: RHEA:15793 +is_a: GO:0004074 ! biliverdin reductase (NAD(P)+) activity +created_by: hjd +creation_date: 2020-07-02T01:50:24Z + +[Term] +id: GO:0106278 +name: regulation of UDP-N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the UDP-N_acetylglucosamine biosynthetic process." [PMID:32579556] +synonym: "regulation of UDP-GlcNAc biosynthetic process" RELATED [] +synonym: "regulation of UDP-N-acetylglucosamine anabolism" RELATED [] +synonym: "regulation of UDP-N-acetylglucosamine biosynthesis" RELATED [] +synonym: "regulation of UDP-N-acetylglucosamine formation" RELATED [] +synonym: "regulation of UDP-N-acetylglucosamine synthesis" RELATED [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051174 ! regulation of phosphorus metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process +relationship: regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process +created_by: hjd +creation_date: 2020-07-09T17:20:49Z + +[Term] +id: GO:0106279 +name: negative regulation of UDP-N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process." [PMID:32579556] +synonym: "negative regulation of UDP-GlcNAc biosynthesis" RELATED [] +synonym: "negative regulation of UDP-GlcNAc biosynthetic process" RELATED [] +synonym: "negative regulation of UDP-N-acetylglucosamine anabolism" RELATED [] +synonym: "negative regulation of UDP-N-acetylglucosamine biosynthesis" RELATED [] +synonym: "negative regulation of UDP-N-acetylglucosamine formation" RELATED [] +synonym: "negative regulation of UDP-N-acetylglucosamine synthesis" RELATED [] +is_a: GO:0010563 ! negative regulation of phosphorus metabolic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:0106278 ! regulation of UDP-N-acetylglucosamine biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process +relationship: negatively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process +created_by: hjd +creation_date: 2020-07-09T17:26:06Z + +[Term] +id: GO:0106280 +name: positive regulation of UDP-N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process." [PMID:32579556] +synonym: "positive egulation of UDP-N-acetylglucosamine formation" RELATED [] +synonym: "positive regulation of UDP-GlcNAc biosynthetic process" RELATED [] +synonym: "positive regulation of UDP-N-acetylglucosamine anabolism" RELATED [] +synonym: "positive regulation of UDP-N-acetylglucosamine biosynthesis" RELATED [] +synonym: "positive regulation of UDP-N-acetylglucosamine synthesis" RELATED [] +is_a: GO:0010562 ! positive regulation of phosphorus metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:0106278 ! regulation of UDP-N-acetylglucosamine biosynthetic process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process +relationship: positively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process +created_by: hjd +creation_date: 2020-07-09T18:12:08Z + [Term] id: GO:0110001 name: toxin-antitoxin complex @@ -451167,6 +448748,7 @@ id: GO:0110134 name: meiotic drive namespace: biological_process def: "A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis." [GOC:mah, PMID:26920473, PMID:29322557, PMID:29499907] +subset: goslim_pombe is_a: GO:0022414 ! reproductive process created_by: kmv creation_date: 2019-01-02T17:37:09Z @@ -451385,8 +448967,9 @@ creation_date: 2019-06-10T18:18:01Z id: GO:0110152 name: RNA NAD-cap (NAD-forming) hydrolase activity namespace: molecular_function -def: "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)." [GOC:sp, PMID:28283058] +def: "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)." [GOC:sp, PMID:28283058, RHEA:60880] comment: This reaction specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. +xref: RHEA:60880 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides created_by: kmv creation_date: 2019-07-08T15:55:11Z @@ -451454,7 +449037,7 @@ creation_date: 2019-07-15T18:30:51Z id: GO:0110159 name: regulation of mitotic spindle formation (spindle phase one) namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw] +def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw, PMID:27697865] is_a: GO:0032888 ! regulation of mitotic spindle elongation is_a: GO:1901673 ! regulation of mitotic spindle assembly intersection_of: GO:0065007 ! biological regulation @@ -451467,7 +449050,7 @@ creation_date: 2019-08-12T15:10:26Z id: GO:0110160 name: negative regulation of mitotic spindle formation (spindle phase one) namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw] +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw] is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one) is_a: GO:1902845 ! negative regulation of mitotic spindle elongation is_a: GO:1905831 ! negative regulation of spindle assembly @@ -451481,7 +449064,7 @@ creation_date: 2019-08-12T15:18:32Z id: GO:0110161 name: positive regulation of mitotic spindle formation (spindle phase one) namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle formation (spindle phase one)." [GOC:vw] +def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw] is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one) is_a: GO:1902846 ! positive regulation of mitotic spindle elongation is_a: GO:1905832 ! positive regulation of spindle assembly @@ -451495,7 +449078,7 @@ creation_date: 2019-08-12T15:21:08Z id: GO:0110162 name: regulation of mitotic spindle elongation (spindle phase three) namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of mitotic spindle elongation (spindle phase three)." [GOC:vw, PMID:27697865] +def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three)." [GOC:vw, PMID:27697865] is_a: GO:0032888 ! regulation of mitotic spindle elongation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) @@ -451507,7 +449090,7 @@ creation_date: 2019-08-12T15:26:01Z id: GO:0110163 name: negative regulation of mitotic spindle elongation (spindle phase three) namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation (spindle phase three)." [GOC:vw, PMID:27697865] +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three)." [GOC:vw, PMID:27697865] is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three) is_a: GO:1902845 ! negative regulation of mitotic spindle elongation intersection_of: GO:0065007 ! biological regulation @@ -451520,7 +449103,7 @@ creation_date: 2019-08-12T15:29:43Z id: GO:0110164 name: positive regulation of mitotic spindle elongation (spindle phase three) namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation (spindle phase three)." [GOC:vw, PMID:27697865] +def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three)." [GOC:vw, PMID:27697865] is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three) is_a: GO:1902846 ! positive regulation of mitotic spindle elongation intersection_of: GO:0065007 ! biological regulation @@ -451750,6 +449333,13 @@ def: "Removes cholesterol from a membrane or a monolayer lipid particle, transpo synonym: "cholesterol carrier activity" EXACT [] synonym: "cholesterol transporter activity" BROAD [] synonym: "intermembrane cholesterol transfer activity" NARROW [] +xref: Reactome:R-HSA-1454928 "ABCG4 may mediate cholesterol efflux" +xref: Reactome:R-HSA-216723 "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane" +xref: Reactome:R-HSA-265443 "NPC1L1-mediated cholesterol uptake" +xref: Reactome:R-HSA-265545 "NPC1L1-mediated phytosterol uptake" +xref: Reactome:R-HSA-266082 "ABCG1-mediated transport of intracellular cholesterol to the cell surface" +xref: Reactome:R-HSA-5682111 "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane" +xref: Reactome:R-HSA-8951850 "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane" is_a: GO:0120015 ! sterol transfer activity relationship: has_part GO:0015485 ! cholesterol binding created_by: krc @@ -452624,31 +450214,34 @@ creation_date: 2017-10-10T15:31:40Z [Term] id: GO:0120104 -name: actomyosin contractile ring, proximal layer +name: mitotic actomyosin contractile ring, proximal layer namespace: cellular_component -def: "The region of the actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located." [GOC:krc, GOC:vw, PMID:28914606] +def: "The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located." [GOC:krc, GOC:vw, PMID:28914606] +synonym: "actomyosin contractile ring, proximal layer" EXACT [] is_a: GO:0110165 ! cellular anatomical entity -relationship: part_of GO:0005826 ! actomyosin contractile ring +relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring created_by: krc creation_date: 2017-10-11T22:49:58Z [Term] id: GO:0120105 -name: actomyosin contractile ring, intermediate layer +name: mitotic actomyosin contractile ring, intermediate layer namespace: cellular_component -def: "The region of the actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer." [GOC:krc, GOC:vw, PMID:28914606] +def: "The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer." [GOC:krc, GOC:vw, PMID:28914606] +synonym: "actomyosin contractile ring, intermediate layer" EXACT [] is_a: GO:0110165 ! cellular anatomical entity -relationship: part_of GO:0005826 ! actomyosin contractile ring +relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring created_by: krc creation_date: 2017-10-11T22:54:40Z [Term] id: GO:0120106 -name: actomyosin contractile ring, distal actin filament layer +name: mitotic actomyosin contractile ring, distal actin filament layer namespace: cellular_component -def: "The region of the actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to." [GOC:krc, GOC:vw, PMID:28914606] +def: "The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to." [GOC:krc, GOC:vw, PMID:28914606] +synonym: "actomyosin contractile ring, distal actin filament layer" EXACT [] is_a: GO:0110165 ! cellular anatomical entity -relationship: part_of GO:0005826 ! actomyosin contractile ring +relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring created_by: krc creation_date: 2017-10-11T22:56:44Z @@ -452669,6 +450262,7 @@ namespace: molecular_function def: "Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H(2)O <=> (DNA)-3'-phosphate + GMP." [PMID:26007660] synonym: "DNA-3'pp5'G guanylate hydrolase" EXACT [] xref: EC:3.1.12.2 +xref: RHEA:52140 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds created_by: krc creation_date: 2017-10-17T22:12:59Z @@ -452840,7 +450434,7 @@ creation_date: 2018-01-29T19:28:56Z id: GO:0120124 name: membrane fusion priming complex namespace: cellular_component -def: "A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes." [GOC:lnp, PMID:90153011] +def: "A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes." [GOC:lnp, PMID:9015301] synonym: "GATE-16 complex" EXACT [] synonym: "LMA1 complex" EXACT [] xref: IntAct:EBI-16411729 @@ -453595,6 +451189,7 @@ id: GO:0120188 name: regulation of bile acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] +is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0044070 ! regulation of anion transport is_a: GO:0051046 ! regulation of secretion @@ -453609,6 +451204,7 @@ id: GO:0120189 name: positive regulation of bile acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] +is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0120188 ! regulation of bile acid secretion @@ -453624,6 +451220,7 @@ id: GO:0120190 name: negative regulation of bile acid secretion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] +is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0120188 ! regulation of bile acid secretion @@ -454091,6 +451688,126 @@ relationship: part_of GO:0060541 ! respiratory system development created_by: krc creation_date: 2020-02-24T17:13:10Z +[Term] +id: GO:0120225 +name: coenzyme A binding +namespace: molecular_function +def: "Interacting selectively and non-covalently with coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:krc, ISBN:0198547684] +synonym: "CoA binding" EXACT [] +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0043168 ! anion binding +created_by: krc +creation_date: 2020-05-06T18:22:56Z + +[Term] +id: GO:0120226 +name: succinyl-CoA binding +namespace: molecular_function +def: "Interacting selectively and non-covalently with succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component." [GOC:krc] +synonym: "succinyl-coenzyme A binding" EXACT [] +is_a: GO:0120227 ! acyl-CoA binding +created_by: krc +creation_date: 2020-05-19T15:51:32Z + +[Term] +id: GO:0120227 +name: acyl-CoA binding +namespace: molecular_function +def: "Interacting selectively and non-covalently with an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid." [GOC:krc] +synonym: "acyl binding" BROAD [] +synonym: "acyl-coenzyme A binding" EXACT [] +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0033218 ! amide binding +is_a: GO:0043168 ! anion binding +is_a: GO:1901681 ! sulfur compound binding +created_by: krc +creation_date: 2020-05-19T16:06:24Z + +[Term] +id: GO:0120228 +name: outer dynein arm docking complex +namespace: cellular_component +def: "A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules." [GOC:krc, PMID:15064350, PMID:24067530, PMID:25192045, PMID:27486780, PMID:8045937] +synonym: "ODA docking complex" RELATED [PMID:27486780] +synonym: "ODA-DC" RELATED [PMID:27486780] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005930 ! axoneme +created_by: krc +creation_date: 2020-06-05T23:30:44Z + +[Term] +id: GO:0120229 +name: protein localization to motile cilium +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a motile cilium." [GOC:krc, PMID:27486780] +synonym: "protein localization to nonmotile primary cilium" RELATED [] +is_a: GO:0061512 ! protein localization to cilium +created_by: krc +creation_date: 2020-06-05T23:43:04Z + +[Term] +id: GO:0120230 +name: recombinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a recombinase." [GOC:mah, PMID:32414915] +is_a: GO:0008047 ! enzyme activator activity +created_by: krc +creation_date: 2020-06-18T15:54:26Z + +[Term] +id: GO:0120231 +name: DNA recombinase auxiliary factor complex +namespace: cellular_component +def: "A protein complex that binds to a recombinase and incrseases its activity." [PMID:32414915] +synonym: "DNA recombinase accessory factor complex" EXACT [PMID:32414915] +synonym: "DNA recombinase activator complex" EXACT [PMID:32414915] +is_a: GO:0150005 ! enzyme activator complex +created_by: krc +creation_date: 2020-06-18T16:12:52Z + +[Term] +id: GO:0120232 +name: prenyl-FMNH2 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in prenyl-FMNH2, an essential cofactor for the decarboxylase enzymes UbiD and Fdc1." [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754] +synonym: "prenyl-FMNH2 anabolism" EXACT [] +synonym: "prenyl-FMNH2 biosynthesis" EXACT [] +synonym: "prenyl-FMNH2 formation" EXACT [] +synonym: "prenyl-FMNH2 synthesis" EXACT [] +synonym: "prenylated FMNH2 anabolism" EXACT [] +synonym: "prenylated FMNH2 biosynthesis" EXACT [] +synonym: "prenylated FMNH2 biosynthetic process" EXACT [] +synonym: "prenylated FMNH2 formation" EXACT [] +synonym: "prenylated FMNH2 synthesis" EXACT [] +is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process +is_a: GO:0042727 ! flavin-containing compound biosynthetic process +created_by: krc +creation_date: 2020-06-30T19:09:11Z + +[Term] +id: GO:0120233 +name: prenyl-FMNH2 binding +namespace: molecular_function +def: "Interacting selectively and non-covalently with prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1." [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754] +synonym: "prenylated FMNH2 binding" EXACT [] +is_a: GO:0032553 ! ribonucleotide binding +is_a: GO:0043168 ! anion binding +created_by: krc +creation_date: 2020-06-30T19:32:01Z + +[Term] +id: GO:0120234 +name: stereocilium coat +namespace: cellular_component +def: "A glycocalyx on the the endolymphatic surface of a cochlear hair cell that coats the external surface of each stereocilium and maintains a small distance between adjacent stereocilia in the bundle." [GOC:krc, ISBN:9781461268918, PMID:31444330, PMID:3583936] +synonym: "auditory hair cell glycocalyx" BROAD [] +synonym: "stereocilium glycocalyx" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032420 ! stereocilium +created_by: krc +creation_date: 2020-07-15T00:56:35Z + [Term] id: GO:0140007 name: KICSTOR complex @@ -454105,7 +451822,6 @@ id: GO:0140009 name: L-aspartate import across plasma membrane namespace: biological_process def: "The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000069, PMID:7914198] -is_a: GO:0001504 ! neurotransmitter uptake is_a: GO:0070778 ! L-aspartate transmembrane transport is_a: GO:0089718 ! amino acid import across plasma membrane created_by: pg @@ -454795,7 +452511,7 @@ creation_date: 2017-09-14T10:32:59Z id: GO:0140097 name: catalytic activity, acting on DNA namespace: molecular_function -def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring\,GOC\:pdt] +def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] is_a: GO:0003824 ! catalytic activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14225 xsd:anyURI created_by: pg @@ -454805,7 +452521,7 @@ creation_date: 2017-09-14T12:03:51Z id: GO:0140098 name: catalytic activity, acting on RNA namespace: molecular_function -def: "Catalytic activity that acts to modify RNA." [GOC:molecular_function_refactoring\,GOC\:pdt] +def: "Catalytic activity that acts to modify RNA." [GOC:molecular_function_refactoring, GOC:pdt] is_a: GO:0003824 ! catalytic activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14225 xsd:anyURI created_by: pg @@ -454848,7 +452564,7 @@ namespace: molecular_function def: "Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:molecular_function_refactoring, GOC:pdt] subset: gocheck_do_not_annotate is_a: GO:0003674 ! molecular_function -relationship: has_part GO:0051536 ! iron-sulfur cluster binding +relationship: has_part GO:0036094 ! small molecule binding property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14221 xsd:anyURI created_by: pg creation_date: 2017-09-19T13:10:18Z @@ -454891,7 +452607,7 @@ def: "A molecular function that controls the rate, timing and/or magnitude of tr subset: gocheck_do_not_annotate subset: goslim_flybase_ribbon subset: goslim_plant -is_a: GO:0003674 ! molecular_function +is_a: GO:0098772 ! molecular function regulator property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/13588 xsd:anyURI created_by: pg creation_date: 2017-10-18T07:05:44Z @@ -455043,6 +452759,7 @@ name: iron-sulfur cluster carrier activity namespace: molecular_function def: "Binding to an iron-sulfur cluster and delivering it to an acceptor molecule." [PMID:22966982, PMID:29051382] is_a: GO:0140104 ! molecular carrier activity +relationship: has_part GO:0051536 ! iron-sulfur cluster binding property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14539 xsd:anyURI created_by: pg creation_date: 2017-11-10T08:55:38Z @@ -456360,9 +454077,11 @@ name: intramembrane lipid transporter activity namespace: molecular_function def: "Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084] synonym: "flippase activity" RELATED [] +synonym: "translocase activity" BROAD [] is_a: GO:0005319 ! lipid transporter activity relationship: part_of GO:0034204 ! lipid translocation property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17648 xsd:anyURI +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19477 xsd:anyURI created_by: pg creation_date: 2019-03-01T20:14:09Z @@ -456380,7 +454099,7 @@ creation_date: 2019-03-22T14:25:43Z id: GO:0140311 name: protein sequestering activity namespace: molecular_function -def: "The selective interaction of a protein with a specific protein, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:1493333] +def: "The selective interaction of a protein with a specific protein, to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:1493333] is_a: GO:0140313 ! molecular sequestering activity intersection_of: GO:0140313 ! molecular sequestering activity intersection_of: has_part GO:0005515 ! protein binding @@ -456405,7 +454124,7 @@ creation_date: 2019-03-26T17:01:45Z id: GO:0140313 name: molecular sequestering activity namespace: molecular_function -def: "The selective interaction of a protein with a specific molecule, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076] +def: "The selective interaction of a protein with a specific molecule to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076] is_a: GO:0003674 ! molecular_function relationship: has_part GO:0005488 ! binding created_by: pg @@ -456415,8 +454134,8 @@ creation_date: 2019-03-28T10:00:25Z id: GO:0140314 name: calcium ion sequestering activity namespace: molecular_function -def: "The selective interaction of a protein with a calcium ion, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076] -is_a: GO:0140313 ! molecular sequestering activity +def: "The selective interaction of a protein with a calcium ion to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076] +is_a: GO:0140487 ! metal ion sequestering activity intersection_of: GO:0140313 ! molecular sequestering activity intersection_of: has_part GO:0005509 ! calcium ion binding relationship: has_part GO:0005509 ! calcium ion binding @@ -456427,8 +454146,8 @@ creation_date: 2019-03-28T10:07:18Z id: GO:0140315 name: iron ion sequestering activity namespace: molecular_function -def: "The selective interaction of a protein with an iron ion, thereby preventing it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:27780864] -is_a: GO:0140313 ! molecular sequestering activity +def: "The selective interaction of a protein with an iron ion to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:27780864] +is_a: GO:0140487 ! metal ion sequestering activity intersection_of: GO:0140313 ! molecular sequestering activity intersection_of: has_part GO:0005506 ! iron ion binding relationship: has_part GO:0005506 ! iron ion binding @@ -456462,6 +454181,8 @@ def: "Directly binding to a specific protein and delivering it to a specific cel comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. synonym: "protein carrier activity" RELATED [] synonym: "protein transport chaperone" RELATED [] +xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network" +xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" is_a: GO:0005215 ! transporter activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17073 xsd:anyURI created_by: pg @@ -456558,7 +454279,7 @@ id: GO:0140327 name: flippase activity namespace: molecular_function def: "Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase] -comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation. +comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaftlet of a membrane). synonym: "flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity created_by: pg @@ -456569,7 +454290,7 @@ id: GO:0140328 name: floppase activity namespace: molecular_function def: "Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase] -comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. Some authors however use the names flippases and floppases interchangeably to denote any enzyme catalyzing transbilayer lipid motion, in some cases even in the absence of ATP requirements (PMID 20043909). The direction of the translocation should be taken into account for annotation. +comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the cytosolic to the exoplasmic leaftlet of a membrane). synonym: "floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity created_by: pg @@ -456852,6 +454573,12 @@ synonym: "ABC-type uptake permease activity" EXACT [] synonym: "ATP binding cassette transporter" EXACT [] synonym: "ATP-binding cassette (ABC) transporter activity" EXACT [] synonym: "ATP-binding cassette transporter" EXACT [] +xref: Reactome:R-HSA-266070 "LTC4 is exported from the cytosol by ABCC1" +xref: Reactome:R-HSA-5223313 "ABCD4 may transport Cbl from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-5362459 "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol" +xref: Reactome:R-HSA-5387389 "Hh processing variants are translocated to the cytosol in a VCP-dependent manner" +xref: Reactome:R-HSA-5683325 "Defective ABCD4 does not transport Cbl from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-9661405 "ABCC1 transports BIL from cytosol to extracellular region (blood)" xref: TC:3.A.1 xref: Wikipedia:ATP-binding_cassette_transporter is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity @@ -457002,7 +454729,6 @@ namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product." [PMID:28763571] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process @@ -457155,7 +454881,7 @@ synonym: "effector-dependent suppression of host immune innate response by symbi synonym: "effector-mediated suppression of host immune innate response by symbiont" EXACT [] synonym: "effector-mediated suppression of host innate immunity" EXACT [] synonym: "effector-triggered suppression of host immune innate response by symbiont" EXACT [] -is_a: GO:0140404 ! effector-mediated modulation of host innate immune response by symbiont +is_a: GO:0052170 ! suppression by symbiont of host innate immune response created_by: pg creation_date: 2019-12-05T11:34:55Z @@ -457285,7 +455011,7 @@ id: GO:0140415 name: effector-mediated modulation of host defenses by symbiont namespace: biological_process def: "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:30610168] -is_a: GO:0030682 ! mitigation of host defenses by symbiont +is_a: GO:0140418 ! effector-mediated modulation of host process by symbiont created_by: pg creation_date: 2020-01-20T16:46:41Z @@ -457317,7 +455043,7 @@ def: "A process mediated by a molecule secreted by a symbiont that results in th synonym: "effector mediated modulation of host process by symbiont" EXACT [] synonym: "effector triggered modulation of host process by symbiont" EXACT [] synonym: "effector-dependent modulation of host process by symbiont" EXACT [] -is_a: GO:0140415 ! effector-mediated modulation of host defenses by symbiont +is_a: GO:0030682 ! mitigation of host defenses by symbiont property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18605 xsd:anyURI created_by: pg creation_date: 2020-01-29T21:24:42Z @@ -457391,13 +455117,25 @@ creation_date: 2020-02-11T11:08:57Z id: GO:0140429 name: positive regulation of mitotic sister chromatid biorientation namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed." [PMID:20739936] +alt_id: GO:0098783 +alt_id: GO:1990598 +def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed." [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536, PMID:20739936, PMID:21306900] +synonym: "correction of merotelic kinetochore attachment, mitotic" NARROW [] +synonym: "correction of mono-orientation defects" NARROW [] +synonym: "correction of syntelic kinetochore attachment, mitotic" NARROW [GOC:vw] +synonym: "repair of mitotic merotelic kinetochore attachment defect" NARROW [] +synonym: "repair of mitotic merotelic kinetochore attachment defects" NARROW [] +synonym: "repair of mitotic mono-orientation defect" NARROW [] +synonym: "repair of mitotic mono-orientation defects" NARROW [] +is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling +is_a: GO:0140273 ! repair of mitotic kinetochore microtubule attachment defect is_a: GO:1902425 ! positive regulation of attachment of mitotic spindle microtubules to kinetochore intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:1990758 ! mitotic sister chromatid biorientation relationship: positively_regulates GO:1990758 ! mitotic sister chromatid biorientation -created_by: pg -creation_date: 2020-02-19T05:16:40Z +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18815 xsd:anyURI +created_by: jl +creation_date: 2015-01-05T16:54:39Z [Term] id: GO:0140430 @@ -457541,7 +455279,9 @@ name: mitochondrion-plasma membrane adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:31582398] synonym: "mitochondrion plasma membrane adaptor activity" EXACT [] +synonym: "mitochondrion plasma membrane tether activity" EXACT [] synonym: "plasma membrane-mitochondrion adaptor activity" EXACT [] +synonym: "plasma membrane-mitochondrion tether activity" EXACT [] is_a: GO:0043495 ! protein-membrane adaptor activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/pull/19140 xsd:anyURI created_by: pg @@ -457551,7 +455291,7 @@ creation_date: 2020-03-24T13:11:20Z id: GO:0140444 name: cytoskeleton-nuclear membrane anchor activity namespace: molecular_function -def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the plasma membrane." [PMID:16237665] +def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane." [PMID:16237665] synonym: "cytoskeletal protein-nuclear membrane adaptor activity" EXACT [] synonym: "cytoskeletal protein-nuclear membrane anchor activity" EXACT [] synonym: "cytoskeleton nuclear membrane anchor activity" EXACT [] @@ -457616,9 +455356,12 @@ name: centromere-nuclear envelope anchor activity namespace: molecular_function def: "The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location." [PMID:31635174] synonym: "centromere nuclear envelope anchor activity" EXACT [] +synonym: "centromere nuclear envelope tether activity" EXACT [] synonym: "centromere-inner nuclear envelope anchor activity" EXACT [] +synonym: "centromere-inner nuclear envelope tether activity" EXACT [] synonym: "chromosome, centromeric region-nuclear envelope anchor activity" EXACT [] synonym: "nuclear envelope-centromere anchor activity" EXACT [] +synonym: "nuclear envelope-centromere tether activity" EXACT [] is_a: GO:0043495 ! protein-membrane adaptor activity relationship: part_of GO:0072766 ! centromere clustering at the mitotic interphase nuclear envelope property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19227 xsd:anyURI @@ -457687,7 +455430,8 @@ name: meiotic spindle pole body duplication namespace: biological_process def: "The release of duplicated meiotic spindle pole bodies (SPBs)." [PMID:31532702] synonym: "initial spindle pole body separation involved in meiosis I" EXACT [] -is_a: GO:0000073 ! initial mitotic spindle pole body separation +is_a: GO:0110100 ! spindle pole body separation +is_a: GO:1903046 ! meiotic cell cycle process property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17971 xsd:anyURI created_by: pg creation_date: 2020-04-22T19:07:22Z @@ -457733,6 +455477,290 @@ property_value: term_tracker_item https://github.com/geneontology/go-ontology/is created_by: pg creation_date: 2020-04-30T07:34:38Z +[Term] +id: GO:0140461 +name: subtelomeric heterochromatin organization +namespace: biological_process +def: "The organization of chromatin into heterochromatin at the subtelomeric region of a chromosome." [PMID:26744419] +is_a: GO:0032200 ! telomere organization +is_a: GO:0070828 ! heterochromatin organization +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19396 xsd:anyURI +created_by: pg +creation_date: 2020-05-06T07:46:53Z + +[Term] +id: GO:0140462 +name: pericentric heterochromatin organization +namespace: biological_process +def: "The organization of chromatin into heterochromatin at the pericentric region of a chromosome." [PMID:26744419] +is_a: GO:0070828 ! heterochromatin organization +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19396 xsd:anyURI +created_by: pg +creation_date: 2020-05-06T07:47:09Z + +[Term] +id: GO:0140463 +name: chromatin adaptor +namespace: molecular_function +def: "The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex." [PMID:32277274] +synonym: "chromatin adaptor activity" EXACT [] +synonym: "chromatin receptor" EXACT [] +synonym: "chromatin recruitment" RELATED [] +synonym: "protein-chromatin adaptor activity" EXACT [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity +relationship: has_part GO:0003682 ! chromatin binding +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17064 xsd:anyURI +created_by: pg +creation_date: 2020-05-08T12:31:39Z + +[Term] +id: GO:0140464 +name: silent mating-type cassette heterochromatin organization +namespace: biological_process +def: "The organization of chromatin into heterochromatin at a silent mating-type cassette locus." [PMID:26744419] +is_a: GO:0070828 ! heterochromatin organization +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19396 xsd:anyURI +created_by: pg +creation_date: 2020-05-13T05:13:24Z + +[Term] +id: GO:0140466 +name: iron-sulfur cluster export from the mitochondrion +namespace: biological_process +def: "The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane." [PMID:31040179] +is_a: GO:1902497 ! iron-sulfur cluster transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19504 xsd:anyURI +created_by: pg +creation_date: 2020-05-22T10:01:36Z + +[Term] +id: GO:0140467 +name: integrated stress response signaling +namespace: biological_process +def: "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041] +synonym: "ISR" RELATED [] +xref: Wikipedia:Integrated_stress_response +is_a: GO:0033554 ! cellular response to stress +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19153 xsd:anyURI +created_by: pg +creation_date: 2020-05-26T08:04:10Z + +[Term] +id: GO:0140468 +name: HRI-mediated signaling +namespace: biological_process +def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock." [PMID:27629041] +synonym: "EIF2AK1-mediated signaling" EXACT [] +is_a: GO:0140467 ! integrated stress response signaling +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19153 xsd:anyURI +created_by: pg +creation_date: 2020-05-26T08:46:15Z + +[Term] +id: GO:0140469 +name: GCN2-mediated signaling +namespace: biological_process +def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation." [PMID:27629041] +synonym: "EIF2AK4-mediated signaling" EXACT [] +is_a: GO:0034198 ! cellular response to amino acid starvation +is_a: GO:0140467 ! integrated stress response signaling +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19153 xsd:anyURI +created_by: pg +creation_date: 2020-05-26T08:47:25Z + +[Term] +id: GO:0140471 +name: positive regulation of transepithelial migration of symbiont in host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host." [PMID:29113016] +synonym: "positive regulation of transmigration of symbiont in host" RELATED [] +is_a: GO:0043903 ! regulation of symbiotic process +is_a: GO:0048518 ! positive regulation of biological process +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0035756 ! transepithelial migration of symbiont in host +relationship: positively_regulates GO:0035756 ! transepithelial migration of symbiont in host +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19601 xsd:anyURI +created_by: pg +creation_date: 2020-06-11T15:32:38Z + +[Term] +id: GO:0140472 +name: cell cortex of non-growing cell tip +namespace: cellular_component +def: "The region directly beneath the plasma membrane at the cell tip at which no growth takes place." [PMID:17895368] +is_a: GO:0051285 ! cell cortex of cell tip +intersection_of: GO:0099738 ! cell cortex region +intersection_of: part_of GO:0035839 ! non-growing cell tip +relationship: part_of GO:0035839 ! non-growing cell tip +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/17249 xsd:anyURI +created_by: pg +creation_date: 2020-06-18T13:33:58Z + +[Term] +id: GO:0140474 +name: mitochondrion-endoplasmic reticulum membrane tether activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:19556461, PMID:27875684] +synonym: "endoplasmic reticulum-mitochondrion membrane adaptor activity" EXACT [] +synonym: "endoplasmic reticulum-mitochondrion membrane tether activity" EXACT [] +synonym: "ER-mitochondrion membrane adaptor activity" EXACT [] +synonym: "ER-mitochondrion membrane tether activity" EXACT [] +synonym: "mitochondrion-endoplasmic reticulum membrane adaptor activity" EXACT [] +synonym: "mitochondrion-ER membrane adaptor activity" EXACT [] +synonym: "mitochondrion-ER membrane tether activity" EXACT [] +is_a: GO:0043495 ! protein-membrane adaptor activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19634 xsd:anyURI +created_by: pg +creation_date: 2020-06-22T07:01:14Z + +[Term] +id: GO:0140475 +name: spindle pole body anchor activity +namespace: molecular_function +def: "The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way." [PMID:19942852] +is_a: GO:0008093 ! cytoskeletal anchor activity +created_by: pg +creation_date: 2020-06-23T15:54:56Z + +[Term] +id: GO:0140479 +name: ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase +namespace: biological_process +def: "A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide." [PMID:22209968, PMID:24828577] +is_a: GO:0052699 ! ergothioneine biosynthetic process +created_by: pg +creation_date: 2020-06-25T09:58:21Z + +[Term] +id: GO:0140480 +name: mitotic spindle pole body insertion into the nuclear envelope +namespace: biological_process +def: "A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane." [PMID:19487457, PMID:24529240] +synonym: "establishment of spindle pole body localisation in nuclear envelope" EXACT [] +synonym: "establishment of spindle pole body localization in nuclear envelope" EXACT [] +synonym: "establishment of spindle pole body localization to nuclear envelope" EXACT [] +is_a: GO:1990608 ! mitotic spindle pole body localization +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/14887 xsd:anyURI +created_by: pg +creation_date: 2020-06-25T14:45:40Z + +[Term] +id: GO:0140481 +name: ATPase-coupled iron-sulfur cluster transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out)." [PMID:31040179] +synonym: "ATPase-coupled Fe-S cluster transmembrane transporter activity" EXACT [] +is_a: GO:0005215 ! transporter activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19685 xsd:anyURI +created_by: pg +creation_date: 2020-06-25T17:41:01Z + +[Term] +id: GO:0140482 +name: iron sensor activity +namespace: molecular_function +def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of iron." [PMID:11956219, PMID:25806539] +is_a: GO:0140299 ! small molecule sensor activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19433 xsd:anyURI +created_by: pg +creation_date: 2020-06-25T20:58:02Z + +[Term] +id: GO:0140483 +name: outer kinetochore adaptor activity +namespace: molecular_function +def: "The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way." [PMID:22521786] +is_a: GO:0030674 ! protein-macromolecule adaptor activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19701 xsd:anyURI +created_by: pg +creation_date: 2020-06-29T08:53:10Z + +[Term] +id: GO:0140486 +name: zinc ion sequestering activity +namespace: molecular_function +def: "The selective interaction of a protein with a zinc ion to prevent it from interacting with sensitive components of a biological system." [PMID:12050156] +is_a: GO:0140487 ! metal ion sequestering activity +intersection_of: GO:0140313 ! molecular sequestering activity +intersection_of: has_part GO:0008270 ! zinc ion binding +relationship: has_part GO:0008270 ! zinc ion binding +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19700 xsd:anyURI +created_by: pg +creation_date: 2020-06-29T09:21:42Z + +[Term] +id: GO:0140487 +name: metal ion sequestering activity +namespace: molecular_function +def: "The selective interaction of a protein with a metal ion to prevent it from interacting with sensitive components of a biological system." [PMID:12050156] +is_a: GO:0140313 ! molecular sequestering activity +intersection_of: GO:0140313 ! molecular sequestering activity +intersection_of: has_part GO:0046872 ! metal ion binding +relationship: has_part GO:0046872 ! metal ion binding +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19700 xsd:anyURI +created_by: pg +creation_date: 2020-06-29T09:23:47Z + +[Term] +id: GO:0140488 +name: heme receptor activity +namespace: molecular_function +def: "Binding specifically to heme to deliver it to a transport vesicle." [PMID:28193844, PMID:32185489] +is_a: GO:0038024 ! cargo receptor activity +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19699 xsd:anyURI +created_by: pg +creation_date: 2020-06-29T14:16:16Z + +[Term] +id: GO:0140489 +name: molecular template activity +namespace: molecular_function +def: "The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence." [GOC:pg] +is_a: GO:0003674 ! molecular_function +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19709 xsd:anyURI +created_by: pg +creation_date: 2020-07-01T08:42:18Z + +[Term] +id: GO:0140490 +name: microtubule nucleation template activity +namespace: molecular_function +def: "The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly." [PMID:20631709, PMID:21993292] +is_a: GO:0140489 ! molecular template activity +created_by: pg +creation_date: 2020-07-01T08:47:54Z + +[Term] +id: GO:0140493 +name: very long-chain fatty acid beta-oxidation +namespace: biological_process +def: "A fatty acid beta-oxidation pathway acting on fatty acid which has a chain length greater than C22 in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:ha, PMID:17028011, PMID:32169171] +is_a: GO:0033540 ! fatty acid beta-oxidation using acyl-CoA oxidase +is_a: GO:0042760 ! very long-chain fatty acid catabolic process +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19735 xsd:anyURI +created_by: pg +creation_date: 2020-07-10T08:39:22Z + +[Term] +id: GO:0140494 +name: migrasome +namespace: cellular_component +def: "A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration." [PMID:25342562, PMID:31371827] +is_a: GO:0043226 ! organelle +created_by: pg +creation_date: 2020-07-10T15:09:40Z + +[Term] +id: GO:0140495 +name: migracytosis +namespace: biological_process +def: "A cell migration-dependent mechanism for releasing cellular contents." [PMID:25342562] +is_a: GO:0016477 ! cell migration +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19760 xsd:anyURI +created_by: pg +creation_date: 2020-07-10T15:13:46Z + [Term] id: GO:0150001 name: primary dendrite @@ -458788,47 +456816,6 @@ relationship: regulates GO:0070633 ! transepithelial transport created_by: bc creation_date: 2019-09-15T07:16:49Z -[Term] -id: GO:0150112 -name: regulation of interleukin-7 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-7 secretion." [GOC:aruk, PMID:25962782] -is_a: GO:0032676 ! regulation of interleukin-7 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0072605 ! interleukin-7 secretion -relationship: regulates GO:0072605 ! interleukin-7 secretion -created_by: bc -creation_date: 2019-10-27T08:50:42Z - -[Term] -id: GO:0150113 -name: negative regulation of interleukin-7 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-7 secretion." [GOC:aruk, PMID:25962782] -is_a: GO:0032716 ! negative regulation of interleukin-7 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:0150112 ! regulation of interleukin-7 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0072605 ! interleukin-7 secretion -relationship: negatively_regulates GO:0072605 ! interleukin-7 secretion -created_by: bc -creation_date: 2019-10-27T08:53:35Z - -[Term] -id: GO:0150114 -name: positive regulation of interleukin-7 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-7 secretion." [GOC:aruk] -is_a: GO:0032756 ! positive regulation of interleukin-7 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:0150112 ! regulation of interleukin-7 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0072605 ! interleukin-7 secretion -relationship: positively_regulates GO:0072605 ! interleukin-7 secretion -created_by: bc -creation_date: 2019-10-27T08:55:49Z - [Term] id: GO:0150115 name: cell-substrate junction organization @@ -458890,271 +456877,113 @@ relationship: negatively_regulates GO:0150105 ! protein localization to cell-cel created_by: bc creation_date: 2019-11-21T13:53:34Z -[Term] -id: GO:0150120 -name: regulation of interleukin-18 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-18 secretion." [GOC:aruk, PMID:23710316] -is_a: GO:0032661 ! regulation of interleukin-18 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0072616 ! interleukin-18 secretion -relationship: regulates GO:0072616 ! interleukin-18 secretion -created_by: bc -creation_date: 2019-11-27T11:37:50Z - -[Term] -id: GO:0150121 -name: negative regulation of interleukin-18 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18 secretion." [GOC:aruk, PMID:23710316] -is_a: GO:0032701 ! negative regulation of interleukin-18 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:0150120 ! regulation of interleukin-18 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0072616 ! interleukin-18 secretion -relationship: negatively_regulates GO:0072616 ! interleukin-18 secretion -created_by: bc -creation_date: 2019-11-27T11:40:37Z - -[Term] -id: GO:0150122 -name: positive regulation of interleukin-18 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-18 secretion." [GOC:aruk] -is_a: GO:0032741 ! positive regulation of interleukin-18 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:0150120 ! regulation of interleukin-18 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0072616 ! interleukin-18 secretion -relationship: positively_regulates GO:0072616 ! interleukin-18 secretion -created_by: bc -creation_date: 2019-11-27T11:44:29Z - -[Term] -id: GO:0150123 -name: regulation of interleukin-33 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-33 biosynthetic process." [GOC:aruk, PMID:29778524] -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -is_a: GO:0150127 ! regulation of interleukin-33 production -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0150126 ! interleukin-33 biosynthetic process -relationship: regulates GO:0150126 ! interleukin-33 biosynthetic process -created_by: bc -creation_date: 2019-12-01T16:39:17Z - -[Term] -id: GO:0150124 -name: negative regulation of interleukin-33 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 biosynthetic process." [GOC:aruk, PMID:29778524] -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0150123 ! regulation of interleukin-33 biosynthetic process -is_a: GO:0150128 ! negative regulation of interleukin-33 production -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0150126 ! interleukin-33 biosynthetic process -relationship: negatively_regulates GO:0150126 ! interleukin-33 biosynthetic process -created_by: bc -creation_date: 2019-12-01T16:39:36Z - -[Term] -id: GO:0150125 -name: positive regulation of interleukin-33 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 biosynthetic process." [GOC:aruk] -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0150123 ! regulation of interleukin-33 biosynthetic process -is_a: GO:0150129 ! positive regulation of interleukin-33 production -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0150126 ! interleukin-33 biosynthetic process -relationship: positively_regulates GO:0150126 ! interleukin-33 biosynthetic process -created_by: bc -creation_date: 2019-12-01T16:39:45Z - -[Term] -id: GO:0150126 -name: interleukin-33 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-33." [GOC:aruk, PMID:29778524] -is_a: GO:0042089 ! cytokine biosynthetic process -is_a: GO:1901566 ! organonitrogen compound biosynthetic process -relationship: part_of GO:0072639 ! interleukin-33 production -created_by: bc -creation_date: 2019-12-01T16:46:17Z - [Term] id: GO:0150127 name: regulation of interleukin-33 production namespace: biological_process +alt_id: GO:0150123 +alt_id: GO:0150130 def: "Any process that modulates the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524] +synonym: "regulation of interleukin-33 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-33 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072639 ! interleukin-33 production relationship: regulates GO:0072639 ! interleukin-33 production created_by: bc -creation_date: 2019-12-01T17:05:01Z +creation_date: 2019-12-03T05:54:03Z [Term] id: GO:0150128 name: negative regulation of interleukin-33 production namespace: biological_process +alt_id: GO:0150124 +alt_id: GO:0150131 def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524] +synonym: "negative regulation of interleukin-33 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-33 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0150127 ! regulation of interleukin-33 production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072639 ! interleukin-33 production relationship: negatively_regulates GO:0072639 ! interleukin-33 production created_by: bc -creation_date: 2019-12-01T17:08:31Z +creation_date: 2019-12-03T05:54:24Z [Term] id: GO:0150129 name: positive regulation of interleukin-33 production namespace: biological_process +alt_id: GO:0150125 +alt_id: GO:0150132 def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 production." [GOC:aruk] +synonym: "positive regulation of interleukin-33 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-33 secretion" NARROW [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0150127 ! regulation of interleukin-33 production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0072639 ! interleukin-33 production relationship: positively_regulates GO:0072639 ! interleukin-33 production created_by: bc -creation_date: 2019-12-01T17:10:56Z - -[Term] -id: GO:0150130 -name: regulation of interleukin-33 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-33 secretion." [GOC:aruk, PMID:29778524] -is_a: GO:0050707 ! regulation of cytokine secretion -is_a: GO:0150127 ! regulation of interleukin-33 production -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0072640 ! interleukin-33 secretion -relationship: regulates GO:0072640 ! interleukin-33 secretion -created_by: bc -creation_date: 2019-12-03T05:54:03Z - -[Term] -id: GO:0150131 -name: negative regulation of interleukin-33 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 secretion." [GOC:aruk, PMID:29778524] -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:0150128 ! negative regulation of interleukin-33 production -is_a: GO:0150130 ! regulation of interleukin-33 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0072640 ! interleukin-33 secretion -relationship: negatively_regulates GO:0072640 ! interleukin-33 secretion -created_by: bc -creation_date: 2019-12-03T05:54:24Z - -[Term] -id: GO:0150132 -name: positive regulation of interleukin-33 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 secretion." [GOC:aruk] -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:0150129 ! positive regulation of interleukin-33 production -is_a: GO:0150130 ! regulation of interleukin-33 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0072640 ! interleukin-33 secretion -relationship: positively_regulates GO:0072640 ! interleukin-33 secretion -created_by: bc creation_date: 2019-12-03T05:54:37Z -[Term] -id: GO:0150133 -name: regulation of interleukin-4 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-4 secretion." [GOC:aruk, PMID:29778524] -is_a: GO:0032673 ! regulation of interleukin-4 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0072602 ! interleukin-4 secretion -relationship: regulates GO:0072602 ! interleukin-4 secretion -created_by: bc -creation_date: 2019-12-03T11:33:28Z - -[Term] -id: GO:0150134 -name: negative regulation of interleukin-4 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4 secretion." [GOC:aruk, PMID:29778524] -is_a: GO:0032713 ! negative regulation of interleukin-4 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:0150133 ! regulation of interleukin-4 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0072602 ! interleukin-4 secretion -relationship: negatively_regulates GO:0072602 ! interleukin-4 secretion -created_by: bc -creation_date: 2019-12-03T11:33:56Z - -[Term] -id: GO:0150135 -name: positive regulation of interleukin-4 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-4 secretion." [GOC:aruk] -is_a: GO:0032753 ! positive regulation of interleukin-4 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:0150133 ! regulation of interleukin-4 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0072602 ! interleukin-4 secretion -relationship: positively_regulates GO:0072602 ! interleukin-4 secretion -created_by: bc -creation_date: 2019-12-03T11:35:42Z - [Term] id: GO:0150136 -name: regulation of interleukin-37 biosynthetic process +name: regulation of interleukin-37 production namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-37 biosynthetic process." [GOC:aruk, PMID:30362558] -is_a: GO:0042035 ! regulation of cytokine biosynthetic process +def: "Any process that modulates the frequency, rate or extent of interleukin-37 production." [GOC:aruk, PMID:30362558] +synonym: "regulation of interleukin-37 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0150137 ! interleukin-37 biosynthetic process -relationship: regulates GO:0150137 ! interleukin-37 biosynthetic process +intersection_of: regulates GO:0150137 ! interleukin-37 production +relationship: regulates GO:0150137 ! interleukin-37 production created_by: bc creation_date: 2019-12-08T08:39:07Z [Term] id: GO:0150137 -name: interleukin-37 biosynthetic process +name: interleukin-37 production namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-37." [GOC:aruk, PMID:30362558] -is_a: GO:0042089 ! cytokine biosynthetic process +def: "The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:aruk, PMID:30362558] +synonym: "interleukin-37 biosynthetic process" NARROW [] +is_a: GO:0001816 ! cytokine production created_by: bc creation_date: 2019-12-08T08:43:09Z [Term] id: GO:0150138 -name: negative regulation of interleukin-37 biosynthetic process +name: negative regulation of interleukin-37 production namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 biosynthetic process." [GOC:aruk, PMID:30362558] -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0150136 ! regulation of interleukin-37 biosynthetic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production." [GOC:aruk, PMID:30362558] +synonym: "negative regulation of interleukin-37 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0150136 ! regulation of interleukin-37 production intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0150137 ! interleukin-37 biosynthetic process -relationship: negatively_regulates GO:0150137 ! interleukin-37 biosynthetic process +intersection_of: negatively_regulates GO:0150137 ! interleukin-37 production +relationship: negatively_regulates GO:0150137 ! interleukin-37 production created_by: bc creation_date: 2019-12-08T08:45:29Z [Term] id: GO:0150139 -name: positive regulation of interleukin-37 biosynthetic process +name: positive regulation of interleukin-37 production namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-37 biosynthetic process." [GOC:aruk] -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0150136 ! regulation of interleukin-37 biosynthetic process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-37 production." [GOC:aruk] +synonym: "positive regulation of interleukin-37 biosynthetic process" NARROW [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0150136 ! regulation of interleukin-37 production intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0150137 ! interleukin-37 biosynthetic process -relationship: positively_regulates GO:0150137 ! interleukin-37 biosynthetic process +intersection_of: positively_regulates GO:0150137 ! interleukin-37 production +relationship: positively_regulates GO:0150137 ! interleukin-37 production created_by: bc creation_date: 2019-12-08T08:47:29Z [Term] id: GO:0150140 -name: regulation of CD86 biosynthetic process +name: regulation of CD86 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882] +synonym: "regulation of CD86 biosynthetic process" EXACT [] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035781 ! CD86 biosynthetic process @@ -459164,11 +456993,12 @@ creation_date: 2019-12-08T09:31:00Z [Term] id: GO:0150141 -name: negative regulation of CD86 biosynthetic process +name: negative regulation of CD86 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882] +synonym: "negative regulation of CD86 biosynthetic process" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process -is_a: GO:0150140 ! regulation of CD86 biosynthetic process +is_a: GO:0150140 ! regulation of CD86 production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0035781 ! CD86 biosynthetic process relationship: negatively_regulates GO:0035781 ! CD86 biosynthetic process @@ -459177,11 +457007,12 @@ creation_date: 2019-12-08T09:33:39Z [Term] id: GO:0150142 -name: positive regulation of CD86 biosynthetic process +name: positive regulation of CD86 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk] +synonym: "positive regulation of CD86 biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process -is_a: GO:0150140 ! regulation of CD86 biosynthetic process +is_a: GO:0150140 ! regulation of CD86 production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0035781 ! CD86 biosynthetic process relationship: positively_regulates GO:0035781 ! CD86 biosynthetic process @@ -459190,9 +457021,10 @@ creation_date: 2019-12-08T09:35:35Z [Term] id: GO:0150143 -name: regulation of CD80 biosynthetic process +name: regulation of CD80 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882] +synonym: "regulation of CD80 biosynthetic process" EXACT [] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035780 ! CD80 biosynthetic process @@ -459202,11 +457034,12 @@ creation_date: 2019-12-08T10:23:43Z [Term] id: GO:0150144 -name: negative regulation of CD80 biosynthetic process +name: negative regulation of CD80 production namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882] +synonym: "negative regulation of CD80 biosynthetic process" EXACT [] is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process -is_a: GO:0150143 ! regulation of CD80 biosynthetic process +is_a: GO:0150143 ! regulation of CD80 production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0035780 ! CD80 biosynthetic process relationship: negatively_regulates GO:0035780 ! CD80 biosynthetic process @@ -459215,11 +457048,12 @@ creation_date: 2019-12-08T10:26:42Z [Term] id: GO:0150145 -name: positive regulation of CD80 biosynthetic process +name: positive regulation of CD80 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk] +synonym: "positive regulation of CD80 biosynthetic process" EXACT [] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process -is_a: GO:0150143 ! regulation of CD80 biosynthetic process +is_a: GO:0150143 ! regulation of CD80 production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0035780 ! CD80 biosynthetic process relationship: positively_regulates GO:0035780 ! CD80 biosynthetic process @@ -459246,94 +457080,47 @@ is_a: GO:0150146 ! cell junction disassembly created_by: bc creation_date: 2019-12-08T11:16:14Z -[Term] -id: GO:0150148 -name: regulation of interleukin-25 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-25 secretion." [GOC:aruk, PMID:27901018] -is_a: GO:0032669 ! regulation of interleukin-25 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0072623 ! interleukin-25 secretion -relationship: regulates GO:0072623 ! interleukin-25 secretion -created_by: bc -creation_date: 2019-12-09T16:51:07Z - -[Term] -id: GO:0150149 -name: negative regulation of interleukin-25 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-25 secretion." [GOC:aruk, PMID:27901018] -is_a: GO:0032709 ! negative regulation of interleukin-25 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:0150148 ! regulation of interleukin-25 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0072623 ! interleukin-25 secretion -relationship: negatively_regulates GO:0072623 ! interleukin-25 secretion -created_by: bc -creation_date: 2019-12-09T16:51:28Z - -[Term] -id: GO:0150150 -name: positive regulation of interleukin-25 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-25 secretion." [GOC:aruk] -is_a: GO:0032749 ! positive regulation of interleukin-25 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:0150148 ! regulation of interleukin-25 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0072623 ! interleukin-25 secretion -relationship: positively_regulates GO:0072623 ! interleukin-25 secretion -created_by: bc -creation_date: 2019-12-09T16:51:44Z - [Term] id: GO:0150151 -name: regulation of interleukin-17A biosynthetic process +name: regulation of interleukin-17A production namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-17A biosynthetic process." [GOC:aruk, PMID:27901018] -is_a: GO:0042035 ! regulation of cytokine biosynthetic process +def: "Any process that modulates the frequency, rate or extent of interleukin-17A production." [GOC:aruk, PMID:27901018] +synonym: "regulation of interleukin-17A biosynthetic process" NARROW [] +is_a: GO:0032660 ! regulation of interleukin-17 production intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0150154 ! interleukin-17A biosynthetic process -relationship: regulates GO:0150154 ! interleukin-17A biosynthetic process +intersection_of: regulates GO:0097087 ! interleukin-17A production +relationship: regulates GO:0097087 ! interleukin-17A production created_by: bc creation_date: 2019-12-11T07:44:52Z [Term] id: GO:0150152 -name: negative regulation of interleukin-17A biosynthetic process +name: negative regulation of interleukin-17A production namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A biosynthetic process." [GOC:aruk, PMID:27901018] -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0150151 ! regulation of interleukin-17A biosynthetic process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A production." [GOC:aruk, PMID:27901018] +synonym: "negative regulation of interleukin-17A biosynthetic process" NARROW [] +is_a: GO:0032700 ! negative regulation of interleukin-17 production +is_a: GO:0150151 ! regulation of interleukin-17A production intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0150154 ! interleukin-17A biosynthetic process -relationship: negatively_regulates GO:0150154 ! interleukin-17A biosynthetic process +intersection_of: negatively_regulates GO:0097087 ! interleukin-17A production +relationship: negatively_regulates GO:0097087 ! interleukin-17A production created_by: bc creation_date: 2019-12-11T07:45:24Z [Term] id: GO:0150153 -name: positive regulation of interleukin-17A biosynthetic process +name: positive regulation of interleukin-17A production namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-17A biosynthetic process." [GOC:aruk] -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0150151 ! regulation of interleukin-17A biosynthetic process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-17A production." [GOC:aruk] +synonym: "positive regulation of interleukin-17A biosynthetic process" NARROW [] +is_a: GO:0032740 ! positive regulation of interleukin-17 production +is_a: GO:0150151 ! regulation of interleukin-17A production intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0150154 ! interleukin-17A biosynthetic process -relationship: positively_regulates GO:0150154 ! interleukin-17A biosynthetic process +intersection_of: positively_regulates GO:0097087 ! interleukin-17A production +relationship: positively_regulates GO:0097087 ! interleukin-17A production created_by: bc creation_date: 2019-12-11T07:45:44Z -[Term] -id: GO:0150154 -name: interleukin-17A biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-17A." [GOC:aruk, PMID:27901018] -is_a: GO:0042089 ! cytokine biosynthetic process -created_by: bc -creation_date: 2019-12-11T07:55:52Z - [Term] id: GO:0150155 name: interleukin-34 production @@ -459343,21 +457130,15 @@ is_a: GO:0001816 ! cytokine production created_by: bc creation_date: 2020-01-06T16:25:25Z -[Term] -id: GO:0150156 -name: interleukin-34 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-34." [GOC:aruk, PMID:26754294] -is_a: GO:0042089 ! cytokine biosynthetic process -relationship: part_of GO:0150155 ! interleukin-34 production -created_by: bc -creation_date: 2020-01-06T16:26:08Z - [Term] id: GO:0150157 name: regulation of interleukin-34 production namespace: biological_process +alt_id: GO:0150156 +alt_id: GO:0150160 def: "Any process that modulates the frequency, rate or extent of interleukin-34 production." [GOC:aruk, PMID:26754294] +synonym: "interleukin-34 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-34 biosynthetic process" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0150155 ! interleukin-34 production @@ -459369,7 +457150,9 @@ creation_date: 2020-01-06T16:30:44Z id: GO:0150158 name: positive regulation of interleukin-34 production namespace: biological_process +alt_id: GO:0150161 def: "Any process that activates or increases the frequency, rate or extent of interleukin-34 production." [GOC:aruk] +synonym: "positive regulation of interleukin-34 biosynthetic process" NARROW [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0150157 ! regulation of interleukin-34 production intersection_of: GO:0065007 ! biological regulation @@ -459382,7 +457165,9 @@ creation_date: 2020-01-06T16:31:00Z id: GO:0150159 name: negative regulation of interleukin-34 production namespace: biological_process +alt_id: GO:0150162 def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production." [GOC:aruk, PMID:26754294] +synonym: "negative regulation of interleukin-34 biosynthetic process" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0150157 ! regulation of interleukin-34 production intersection_of: GO:0065007 ! biological regulation @@ -459391,47 +457176,6 @@ relationship: negatively_regulates GO:0150155 ! interleukin-34 production created_by: bc creation_date: 2020-01-06T16:31:12Z -[Term] -id: GO:0150160 -name: regulation of interleukin-34 biosynthetic process -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-34 biosynthetic process." [GOC:aruk, PMID:26754294] -is_a: GO:0042035 ! regulation of cytokine biosynthetic process -is_a: GO:0150157 ! regulation of interleukin-34 production -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0150156 ! interleukin-34 biosynthetic process -relationship: regulates GO:0150156 ! interleukin-34 biosynthetic process -created_by: bc -creation_date: 2020-01-06T16:31:29Z - -[Term] -id: GO:0150161 -name: positive regulation of interleukin-34 biosynthetic process -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-34 biosynthetic process." [GOC:aruk] -is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process -is_a: GO:0150158 ! positive regulation of interleukin-34 production -is_a: GO:0150160 ! regulation of interleukin-34 biosynthetic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0150156 ! interleukin-34 biosynthetic process -relationship: positively_regulates GO:0150156 ! interleukin-34 biosynthetic process -created_by: bc -creation_date: 2020-01-06T16:32:11Z - -[Term] -id: GO:0150162 -name: negative regulation of interleukin-34 biosynthetic process -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 biosynthetic process." [GOC:aruk, PMID:26754294] -is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process -is_a: GO:0150159 ! negative regulation of interleukin-34 production -is_a: GO:0150160 ! regulation of interleukin-34 biosynthetic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0150156 ! interleukin-34 biosynthetic process -relationship: negatively_regulates GO:0150156 ! interleukin-34 biosynthetic process -created_by: bc -creation_date: 2020-01-06T16:32:23Z - [Term] id: GO:0150163 name: miRNA-mediated activation of transcription by RNA polymerase II @@ -459505,47 +457249,6 @@ relationship: negatively_regulates GO:0043973 ! histone H3-K4 acetylation created_by: bc creation_date: 2020-01-14T12:34:01Z -[Term] -id: GO:0150169 -name: regulation of interleukin-11 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-11 secretion." [GOC:aruk, PMID:29286137] -is_a: GO:0032654 ! regulation of interleukin-11 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0072609 ! interleukin-11 secretion -relationship: regulates GO:0072609 ! interleukin-11 secretion -created_by: bc -creation_date: 2020-01-19T10:39:24Z - -[Term] -id: GO:0150170 -name: negative regulation of interleukin-11 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-11 secretion." [GOC:aruk, PMID:29286137] -is_a: GO:0032694 ! negative regulation of interleukin-11 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:0150169 ! regulation of interleukin-11 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0072609 ! interleukin-11 secretion -relationship: negatively_regulates GO:0072609 ! interleukin-11 secretion -created_by: bc -creation_date: 2020-01-19T10:39:45Z - -[Term] -id: GO:0150171 -name: positive regulation of interleukin-11 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-11 secretion." [GOC:aruk] -is_a: GO:0032734 ! positive regulation of interleukin-11 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:0150169 ! regulation of interleukin-11 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0072609 ! interleukin-11 secretion -relationship: positively_regulates GO:0072609 ! interleukin-11 secretion -created_by: bc -creation_date: 2020-01-19T10:40:06Z - [Term] id: GO:0150172 name: regulation of phosphatidylcholine metabolic process @@ -459661,91 +457364,53 @@ relationship: negatively_regulates GO:0006658 ! phosphatidylserine metabolic pro created_by: bc creation_date: 2020-01-21T14:06:06Z -[Term] -id: GO:0150188 -name: interleukin-32 biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of interleukin-32." [GOC:aruk, PMID:23729669] -is_a: GO:0072637 ! interleukin-32 production -created_by: bc -creation_date: 2020-02-21T10:26:40Z - [Term] id: GO:0150189 -name: regulation of interleukin-32 biosynthetic process +name: regulation of interleukin-32 production namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-32 biosynthetic process." [GOC:aruk, PMID:23729669] +alt_id: GO:0150192 +def: "Any process that modulates the frequency, rate or extent of interleukin-32 production." [GOC:aruk, PMID:23729669] +synonym: "regulation of interleukin-32 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-32 secretion" NARROW [] is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0150188 ! interleukin-32 biosynthetic process -relationship: regulates GO:0150188 ! interleukin-32 biosynthetic process +intersection_of: regulates GO:0072637 ! interleukin-32 production +relationship: regulates GO:0072637 ! interleukin-32 production created_by: bc creation_date: 2020-02-21T10:28:36Z [Term] id: GO:0150190 -name: negative regulation of interleukin-32 biosynthetic process +name: negative regulation of interleukin-32 production namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 biosynthetic process." [GOC:aruk, PMID:23729669] +alt_id: GO:0150193 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 production." [GOC:aruk, PMID:23729669] +synonym: "negative regulation of interleukin-32 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-32 secretion" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production -is_a: GO:0150189 ! regulation of interleukin-32 biosynthetic process +is_a: GO:0150189 ! regulation of interleukin-32 production intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0150188 ! interleukin-32 biosynthetic process -relationship: negatively_regulates GO:0150188 ! interleukin-32 biosynthetic process +intersection_of: negatively_regulates GO:0072637 ! interleukin-32 production +relationship: negatively_regulates GO:0072637 ! interleukin-32 production created_by: bc creation_date: 2020-02-21T10:31:53Z [Term] id: GO:0150191 -name: positive regulation of interleukin-32 biosynthetic process +name: positive regulation of interleukin-32 production namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-32 biosynthetic process." [GOC:aruk] +alt_id: GO:0150194 +def: "Any process that activates or increases the frequency, rate or extent of interleukin-32 production." [GOC:aruk] +synonym: "positive regulation of interleukin-32 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-32 secretion" NARROW [] is_a: GO:0001819 ! positive regulation of cytokine production -is_a: GO:0150189 ! regulation of interleukin-32 biosynthetic process +is_a: GO:0150189 ! regulation of interleukin-32 production intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0150188 ! interleukin-32 biosynthetic process -relationship: positively_regulates GO:0150188 ! interleukin-32 biosynthetic process +intersection_of: positively_regulates GO:0072637 ! interleukin-32 production +relationship: positively_regulates GO:0072637 ! interleukin-32 production created_by: bc creation_date: 2020-02-21T10:33:39Z -[Term] -id: GO:0150192 -name: regulation of interleukin-32 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-32 secretion." [GOC:aruk, PMID:23729669] -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0072638 ! interleukin-32 secretion -relationship: regulates GO:0072638 ! interleukin-32 secretion -created_by: bc -creation_date: 2020-02-21T10:34:56Z - -[Term] -id: GO:0150193 -name: negative regulation of interleukin-32 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 secretion." [GOC:aruk, PMID:23729669] -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:0150192 ! regulation of interleukin-32 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0072638 ! interleukin-32 secretion -relationship: negatively_regulates GO:0072638 ! interleukin-32 secretion -created_by: bc -creation_date: 2020-02-21T10:36:37Z - -[Term] -id: GO:0150194 -name: positive regulation of interleukin-32 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-32 secretion." [GOC:aruk] -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:0150192 ! regulation of interleukin-32 secretion -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0072638 ! interleukin-32 secretion -relationship: positively_regulates GO:0072638 ! interleukin-32 secretion -created_by: bc -creation_date: 2020-02-21T10:40:55Z - [Term] id: GO:0150195 name: transport across blood-cerebrospinal fluid barrier @@ -460571,66 +458236,6 @@ relationship: positively_regulates GO:0071456 ! cellular response to hypoxia created_by: yaf creation_date: 2012-01-17T09:29:19Z -[Term] -id: GO:1900040 -name: regulation of interleukin-2 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf] -synonym: "regulation of IL-2 secretion" EXACT [GOC:TermGenie] -is_a: GO:0032663 ! regulation of interleukin-2 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0070970 ! interleukin-2 secretion -relationship: regulates GO:0070970 ! interleukin-2 secretion -created_by: yaf -creation_date: 2012-01-17T11:20:57Z - -[Term] -id: GO:1900041 -name: negative regulation of interleukin-2 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf] -synonym: "down regulation of IL-2 secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of interleukin-2 secretion" RELATED [GOC:TermGenie] -synonym: "down-regulation of IL-2 secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of interleukin-2 secretion" RELATED [GOC:TermGenie] -synonym: "downregulation of IL-2 secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of interleukin-2 secretion" RELATED [GOC:TermGenie] -synonym: "inhibition of IL-2 secretion" EXACT [GOC:TermGenie] -synonym: "inhibition of interleukin-2 secretion" RELATED [GOC:TermGenie] -synonym: "negative regulation of IL-2 secretion" EXACT [GOC:TermGenie] -is_a: GO:0032703 ! negative regulation of interleukin-2 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:1900040 ! regulation of interleukin-2 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0070970 ! interleukin-2 secretion -relationship: negatively_regulates GO:0070970 ! interleukin-2 secretion -created_by: yaf -creation_date: 2012-01-17T11:21:06Z - -[Term] -id: GO:1900042 -name: positive regulation of interleukin-2 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-2 secretion." [GOC:TermGenie, GOC:yaf] -synonym: "activation of IL-2 secretion" EXACT [GOC:TermGenie] -synonym: "activation of interleukin-2 secretion" RELATED [GOC:TermGenie] -synonym: "positive regulation of IL-2 secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of IL-2 secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of interleukin-2 secretion" RELATED [GOC:TermGenie] -synonym: "up-regulation of IL-2 secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of interleukin-2 secretion" RELATED [GOC:TermGenie] -synonym: "upregulation of IL-2 secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of interleukin-2 secretion" RELATED [GOC:TermGenie] -is_a: GO:0032743 ! positive regulation of interleukin-2 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:1900040 ! regulation of interleukin-2 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0070970 ! interleukin-2 secretion -relationship: positively_regulates GO:0070970 ! interleukin-2 secretion -created_by: yaf -creation_date: 2012-01-17T11:21:10Z - [Term] id: GO:1900043 name: obsolete leptin-mediated signaling pathway involved in negative regulation of appetite @@ -461164,7 +458769,7 @@ def: "Any process that modulates the frequency, rate or extent of ethanol catabo synonym: "regulation of ethanol breakdown" EXACT [GOC:TermGenie] synonym: "regulation of ethanol catabolism" EXACT [GOC:TermGenie] synonym: "regulation of ethanol degradation" EXACT [GOC:TermGenie] -is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006068 ! ethanol catabolic process @@ -461196,7 +458801,7 @@ synonym: "upregulation of ethanol breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of ethanol catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of ethanol catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of ethanol degradation" EXACT [GOC:TermGenie] -is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900065 ! regulation of ethanol catabolic process intersection_of: GO:0008150 ! biological_process @@ -463425,28 +461030,6 @@ relationship: part_of GO:0003140 ! determination of left/right asymmetry in late created_by: bf creation_date: 2012-03-08T02:58:39Z -[Term] -id: GO:1900165 -name: negative regulation of interleukin-6 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion." [GOC:TermGenie, GOC:yaf] -synonym: "down regulation of IL-6 secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of interleukin-6 secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of IL-6 secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of interleukin-6 secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of IL-6 secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of interleukin-6 secretion" EXACT [GOC:TermGenie] -synonym: "inhibition of IL-6 secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of interleukin-6 secretion" NARROW [GOC:TermGenie] -synonym: "negative regulation of IL-6 secretion" EXACT [GOC:TermGenie] -is_a: GO:0032715 ! negative regulation of interleukin-6 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0072604 ! interleukin-6 secretion -relationship: negatively_regulates GO:0072604 ! interleukin-6 secretion -created_by: yaf -creation_date: 2012-03-08T03:27:05Z - [Term] id: GO:1900166 name: regulation of glial cell-derived neurotrophic factor secretion @@ -464910,7 +462493,7 @@ id: GO:1900228 name: regulation of single-species biofilm formation in or on host organism namespace: biological_process def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie] -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process is_a: GO:1900190 ! regulation of single-species biofilm formation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044407 ! single-species biofilm formation in or on host organism @@ -467307,7 +464890,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:0019217 ! regulation of fatty acid metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process -is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -467361,7 +464943,6 @@ id: GO:1900336 name: regulation of methane biosynthetic process from carbon monoxide namespace: biological_process def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie] -is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0043457 ! regulation of cellular respiration is_a: GO:1901577 ! regulation of alkane biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -468005,7 +465586,6 @@ synonym: "up-regulation of RNAi" EXACT [GOC:TermGenie] synonym: "upregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] synonym: "upregulation of RNA interference" EXACT [GOC:TermGenie] synonym: "upregulation of RNAi" EXACT [GOC:TermGenie] -is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing is_a: GO:1900368 ! regulation of RNA interference intersection_of: GO:0008150 ! biological_process @@ -468243,7 +465823,6 @@ synonym: "regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "regulation of asperthecin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036184 ! asperthecin biosynthetic process @@ -468276,7 +465855,6 @@ synonym: "negative regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of asperthecin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900379 ! regulation of asperthecin biosynthetic process @@ -468311,7 +465889,6 @@ synonym: "upregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie synonym: "upregulation of asperthecin formation" EXACT [GOC:TermGenie] synonym: "upregulation of asperthecin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900379 ! regulation of asperthecin biosynthetic process @@ -470213,7 +467790,6 @@ synonym: "upregulation of isopentenyl diphosphate synthesis, mevalonate pathway" is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway @@ -470417,7 +467993,6 @@ synonym: "negative regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA intersection_of: GO:0008150 ! biological_process @@ -470443,7 +468018,6 @@ synonym: "upregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXAC is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA intersection_of: GO:0008150 ! biological_process @@ -470463,7 +468037,6 @@ is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044582 ! butyryl-CoA catabolic process to butanol @@ -470490,7 +468063,6 @@ is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045922 ! negative regulation of fatty acid metabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -470518,7 +468090,6 @@ is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045923 ! positive regulation of fatty acid metabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -470538,7 +468109,6 @@ is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042304 ! regulation of fatty acid biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate relationship: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate @@ -470564,7 +468134,6 @@ is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate @@ -470591,7 +468160,6 @@ is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate @@ -470655,8 +468223,7 @@ synonym: "regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] synonym: "regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] -is_a: GO:0031326 ! regulation of cellular biosynthetic process -is_a: GO:0051193 ! regulation of cofactor metabolic process +is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly relationship: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly @@ -470697,9 +468264,8 @@ synonym: "negative regulation of FeMoco biosynthetic process" EXACT [GOC:TermGen synonym: "negative regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] synonym: "negative regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] -is_a: GO:0031327 ! negative regulation of cellular biosynthetic process -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly +is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly relationship: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly @@ -470740,9 +468306,8 @@ synonym: "upregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGeni synonym: "upregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] -is_a: GO:0031328 ! positive regulation of cellular biosynthetic process -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly +is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly relationship: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly @@ -470755,7 +468320,6 @@ name: regulation of pentose catabolic process to ethanol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] synonym: "regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] -is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -470780,7 +468344,6 @@ synonym: "inhibition of pentose catabolism to ethanol" EXACT [GOC:TermGenie] synonym: "negative regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process -is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -470805,7 +468368,6 @@ synonym: "upregulation of pentose catabolic process to ethanol" EXACT [GOC:TermG synonym: "upregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process -is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -471279,8 +468841,8 @@ name: fumonisin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumonisin." [GOC:TermGenie] synonym: "fumonisin metabolism" RELATED [] +is_a: GO:0019748 ! secondary metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process -is_a: GO:0043385 ! mycotoxin metabolic process created_by: tb creation_date: 2012-05-11T12:53:29Z @@ -471292,7 +468854,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of fumonisi synonym: "fumonisin breakdown" EXACT [] synonym: "fumonisin catabolism" EXACT [] synonym: "fumonisin degradation" RELATED [] -is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900539 ! fumonisin metabolic process @@ -471308,7 +468869,7 @@ synonym: "fumonisin anabolism" EXACT [] synonym: "fumonisin biosynthesis" EXACT [] synonym: "fumonisin formation" EXACT [] synonym: "fumonisin synthesis" EXACT [] -is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1900539 ! fumonisin metabolic process created_by: tb @@ -471496,7 +469057,6 @@ name: asperfuranone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving asperfuranone." [GOC:di, GOC:TermGenie] synonym: "asperfuranone metabolism" EXACT [GOC:TermGenie] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0034311 ! diol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process @@ -471518,7 +469078,6 @@ synonym: "asperfuranone degradation" EXACT [GOC:TermGenie] is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0034313 ! diol catabolic process is_a: GO:0042182 ! ketone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1900552 ! asperfuranone metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -471806,7 +469365,6 @@ name: emodin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving emodin." [GOC:di, GOC:TermGenie] synonym: "emodin metabolism" EXACT [GOC:TermGenie] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:1901661 ! quinone metabolic process @@ -471822,7 +469380,6 @@ synonym: "emodin breakdown" EXACT [GOC:TermGenie] synonym: "emodin catabolism" EXACT [GOC:TermGenie] synonym: "emodin degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900573 ! emodin metabolic process is_a: GO:1901662 ! quinone catabolic process @@ -472030,7 +469587,7 @@ def: "The chemical reactions and pathways involving violaceol I." [GOC:di, GOC:T synonym: "violaceol I metabolism" EXACT [GOC:TermGenie] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0018904 ! ether metabolic process -is_a: GO:0043385 ! mycotoxin metabolic process +is_a: GO:0019748 ! secondary metabolic process created_by: di creation_date: 2012-05-15T06:50:48Z @@ -472043,7 +469600,6 @@ synonym: "violaceol I breakdown" EXACT [GOC:TermGenie] synonym: "violaceol I catabolism" EXACT [GOC:TermGenie] synonym: "violaceol I degradation" EXACT [GOC:TermGenie] is_a: GO:0019614 ! catechol-containing compound catabolic process -is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900588 ! violaceol I metabolic process is_a: GO:1901502 ! ether catabolic process @@ -472060,7 +469616,7 @@ synonym: "violaceol I biosynthesis" EXACT [GOC:TermGenie] synonym: "violaceol I formation" EXACT [GOC:TermGenie] synonym: "violaceol I synthesis" EXACT [GOC:TermGenie] is_a: GO:0009713 ! catechol-containing compound biosynthetic process -is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900588 ! violaceol I metabolic process is_a: GO:1901503 ! ether biosynthetic process created_by: di @@ -472074,7 +469630,7 @@ def: "The chemical reactions and pathways involving violaceol II." [GOC:di, GOC: synonym: "violaceol II metabolism" EXACT [GOC:TermGenie] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0018904 ! ether metabolic process -is_a: GO:0043385 ! mycotoxin metabolic process +is_a: GO:0019748 ! secondary metabolic process created_by: di creation_date: 2012-05-15T06:51:21Z @@ -472087,7 +469643,6 @@ synonym: "violaceol II breakdown" EXACT [GOC:TermGenie] synonym: "violaceol II catabolism" EXACT [GOC:TermGenie] synonym: "violaceol II degradation" EXACT [GOC:TermGenie] is_a: GO:0019614 ! catechol-containing compound catabolic process -is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900591 ! violaceol II metabolic process is_a: GO:1901502 ! ether catabolic process @@ -472104,7 +469659,7 @@ synonym: "violaceol II biosynthesis" EXACT [GOC:TermGenie] synonym: "violaceol II formation" EXACT [GOC:TermGenie] synonym: "violaceol II synthesis" EXACT [GOC:TermGenie] is_a: GO:0009713 ! catechol-containing compound biosynthetic process -is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900591 ! violaceol II metabolic process is_a: GO:1901503 ! ether biosynthetic process created_by: di @@ -472254,7 +469809,6 @@ name: tensidol A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tensidol A." [GOC:di, GOC:TermGenie] synonym: "tensidol A metabolism" EXACT [GOC:TermGenie] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0043603 ! cellular amide metabolic process @@ -472273,7 +469827,6 @@ synonym: "tensidol A breakdown" EXACT [GOC:TermGenie] synonym: "tensidol A catabolism" EXACT [GOC:TermGenie] synonym: "tensidol A degradation" EXACT [GOC:TermGenie] is_a: GO:0042182 ! ketone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900603 ! tensidol A metabolic process @@ -473651,7 +471204,6 @@ synonym: "regulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of emodin formation" EXACT [GOC:TermGenie] synonym: "regulation of emodin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900575 ! emodin biosynthetic process @@ -473689,7 +471241,6 @@ synonym: "negative regulation of emodin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of emodin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of emodin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900664 ! regulation of emodin biosynthetic process @@ -473729,7 +471280,6 @@ synonym: "upregulation of emodin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of emodin formation" EXACT [GOC:TermGenie] synonym: "upregulation of emodin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900664 ! regulation of emodin biosynthetic process @@ -473749,7 +471299,6 @@ synonym: "regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "regulation of endocrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900602 ! endocrocin biosynthetic process @@ -473787,7 +471336,6 @@ synonym: "negative regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "negative regulation of endocrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900667 ! regulation of endocrocin biosynthetic process @@ -473827,7 +471375,6 @@ synonym: "upregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of endocrocin formation" EXACT [GOC:TermGenie] synonym: "upregulation of endocrocin synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900667 ! regulation of endocrocin biosynthetic process @@ -474862,7 +472409,6 @@ synonym: "regulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "regulation of siderophore synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process -is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019290 ! siderophore biosynthetic process @@ -474921,7 +472467,6 @@ synonym: "negative regulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "negative regulation of siderophore synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900704 ! regulation of siderophore biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -474981,7 +472526,6 @@ synonym: "upregulation of siderophore formation" EXACT [GOC:TermGenie] synonym: "upregulation of siderophore synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900704 ! regulation of siderophore biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -476117,8 +473661,6 @@ synonym: "L-Carnitine transport" EXACT [GOC:TermGenie] synonym: "Levocarnitine transport" RELATED [GOC:TermGenie] synonym: "Vitamin BT transport" RELATED [GOC:TermGenie] is_a: GO:0015879 ! carnitine transport -is_a: GO:0015893 ! drug transport -is_a: GO:0051180 ! vitamin transport created_by: jl creation_date: 2012-05-29T02:01:17Z @@ -476494,8 +474036,8 @@ def: "The chemical reactions and pathways involving fumitremorgin B." [GOC:di, G synonym: "fumitremorgin B metabolism" EXACT [GOC:TermGenie] synonym: "Lanosulin metabolic process" RELATED [GOC:TermGenie] synonym: "Lanosulin metabolism" RELATED [GOC:TermGenie] +is_a: GO:0019748 ! secondary metabolic process is_a: GO:0035834 ! indole alkaloid metabolic process -is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: di creation_date: 2012-06-04T09:25:18Z @@ -476513,8 +474055,6 @@ synonym: "Lanosulin catabolic process" RELATED [GOC:TermGenie] synonym: "Lanosulin catabolism" RELATED [GOC:TermGenie] synonym: "Lanosulin degradation" RELATED [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process -is_a: GO:0043387 ! mycotoxin catabolic process -is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900770 ! fumitremorgin B metabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process @@ -476536,7 +474076,7 @@ synonym: "Lanosulin biosynthetic process" RELATED [GOC:TermGenie] synonym: "Lanosulin formation" RELATED [GOC:TermGenie] synonym: "Lanosulin synthesis" RELATED [GOC:TermGenie] is_a: GO:0035835 ! indole alkaloid biosynthetic process -is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900770 ! fumitremorgin B metabolic process is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process created_by: di @@ -476873,7 +474413,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving terrequinone A." [GOC:di, GOC:TermGenie] synonym: "terrequinone A metabolism" EXACT [GOC:TermGenie] is_a: GO:0009820 ! alkaloid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -476891,7 +474430,6 @@ synonym: "terrequinone A breakdown" EXACT [GOC:TermGenie] synonym: "terrequinone A catabolism" EXACT [GOC:TermGenie] synonym: "terrequinone A degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900794 ! terrequinone A metabolic process @@ -476927,7 +474465,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving cordyol C." [GOC:di, GOC:TermGenie] synonym: "cordyol C metabolism" EXACT [GOC:TermGenie] is_a: GO:0009712 ! catechol-containing compound metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0019748 ! secondary metabolic process created_by: di @@ -476941,9 +474478,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of cordyol synonym: "cordyol C breakdown" EXACT [GOC:TermGenie] synonym: "cordyol C catabolism" EXACT [GOC:TermGenie] synonym: "cordyol C degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019614 ! catechol-containing compound catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900797 ! cordyol C metabolic process is_a: GO:1901502 ! ether catabolic process @@ -476960,7 +474495,6 @@ synonym: "cordyol C biosynthesis" EXACT [GOC:TermGenie] synonym: "cordyol C formation" EXACT [GOC:TermGenie] synonym: "cordyol C synthesis" EXACT [GOC:TermGenie] is_a: GO:0009713 ! catechol-containing compound biosynthetic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1900797 ! cordyol C metabolic process is_a: GO:1901503 ! ether biosynthetic process @@ -477195,6 +474729,7 @@ is_a: GO:0008202 ! steroid metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1900619 ! acetate ester metabolic process created_by: di creation_date: 2012-06-04T10:02:28Z @@ -477236,6 +474771,7 @@ is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1900620 ! acetate ester biosynthetic process is_a: GO:1900810 ! helvolic acid metabolic process created_by: di creation_date: 2012-06-04T10:02:58Z @@ -477295,8 +474831,8 @@ def: "The chemical reactions and pathways involving ochratoxin A." [GOC:di, GOC: synonym: "Ochratoxin A metabolic process" EXACT [GOC:TermGenie] synonym: "Ochratoxin A metabolism" EXACT [GOC:TermGenie] is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0019748 ! secondary metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process -is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -477316,10 +474852,8 @@ synonym: "ochratoxin A catabolism" EXACT [GOC:TermGenie] synonym: "Ochratoxin A degradation" EXACT [GOC:TermGenie] synonym: "ochratoxin A degradation" EXACT [GOC:TermGenie] is_a: GO:0042219 ! cellular modified amino acid catabolic process -is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process -is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1900816 ! ochratoxin A metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -477338,8 +474872,8 @@ synonym: "Ochratoxin A formation" EXACT [GOC:TermGenie] synonym: "Ochratoxin A synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process -is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1900816 ! ochratoxin A metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process @@ -477943,7 +475477,6 @@ synonym: "regulation of terrequinone A formation" EXACT [GOC:TermGenie] synonym: "regulation of terrequinone A synthesis" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1900796 ! terrequinone A biosynthetic process @@ -477961,7 +475494,6 @@ synonym: "down-regulation of terrequinone A biosynthetic process" EXACT [GOC:Ter synonym: "downregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process @@ -477981,7 +475513,6 @@ synonym: "up-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermG synonym: "upregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process @@ -478192,7 +475723,6 @@ namespace: biological_process def: "The directed movement of a glycolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport -is_a: GO:0015893 ! drug transport created_by: pr creation_date: 2012-06-12T04:29:56Z @@ -478297,7 +475827,6 @@ name: heptadec-1-ene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] synonym: "heptadec-1-ene metabolism" EXACT [GOC:TermGenie] -is_a: GO:0042810 ! pheromone metabolic process is_a: GO:0043449 ! cellular alkene metabolic process created_by: tt creation_date: 2012-06-13T01:49:51Z @@ -478311,7 +475840,6 @@ synonym: "heptadec-1-ene anabolism" EXACT [GOC:TermGenie] synonym: "heptadec-1-ene biosynthesis" EXACT [GOC:TermGenie] synonym: "heptadec-1-ene formation" EXACT [GOC:TermGenie] synonym: "heptadec-1-ene synthesis" EXACT [GOC:TermGenie] -is_a: GO:0042811 ! pheromone biosynthetic process is_a: GO:0043450 ! alkene biosynthetic process is_a: GO:1900874 ! heptadec-1-ene metabolic process created_by: tt @@ -479359,9 +476887,7 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] synonym: "regulation of glycine import" BROAD [] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane -is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:1904062 ! regulation of cation transmembrane transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903804 ! glycine import across plasma membrane relationship: regulates GO:1903804 ! glycine import across plasma membrane @@ -479378,12 +476904,10 @@ synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie] synonym: "downregulation of glycine import" EXACT [GOC:TermGenie] synonym: "inhibition of glycine import" NARROW [GOC:TermGenie] synonym: "negative regulation of glycine import" BROAD [] -is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1900923 ! regulation of glycine import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903804 ! glycine import across plasma membrane relationship: negatively_regulates GO:1903804 ! glycine import across plasma membrane @@ -479400,12 +476924,10 @@ synonym: "positive regulation of glycine import" BROAD [] synonym: "up regulation of glycine import" EXACT [GOC:TermGenie] synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie] synonym: "upregulation of glycine import" EXACT [GOC:TermGenie] -is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1900923 ! regulation of glycine import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903804 ! glycine import across plasma membrane relationship: positively_regulates GO:1903804 ! glycine import across plasma membrane @@ -479421,7 +476943,6 @@ synonym: "regulation of L-threonine import" BROAD [] synonym: "regulation of L-threonine uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903807 ! L-threonine import across plasma membrane relationship: regulates GO:1903807 ! L-threonine import across plasma membrane @@ -479446,7 +476967,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903807 ! L-threonine import across plasma membrane relationship: negatively_regulates GO:1903807 ! L-threonine import across plasma membrane @@ -479472,7 +476992,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903807 ! L-threonine import across plasma membrane relationship: positively_regulates GO:1903807 ! L-threonine import across plasma membrane @@ -479488,7 +477007,6 @@ synonym: "regulation of L-tyrosine import" BROAD [] synonym: "regulation of L-tyrosine uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903808 ! L-tyrosine import across plasma membrane relationship: regulates GO:1903808 ! L-tyrosine import across plasma membrane @@ -479514,7 +477032,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903808 ! L-tyrosine import across plasma membrane relationship: negatively_regulates GO:1903808 ! L-tyrosine import across plasma membrane @@ -479540,7 +477057,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903808 ! L-tyrosine import across plasma membrane relationship: positively_regulates GO:1903808 ! L-tyrosine import across plasma membrane @@ -481061,7 +478577,6 @@ name: scopolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725] synonym: "scopolamine metabolism" EXACT [GOC:TermGenie] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046448 ! tropane alkaloid metabolic process is_a: GO:0097176 ! epoxide metabolic process created_by: yaf @@ -481076,7 +478591,6 @@ synonym: "scopolamine breakdown" EXACT [GOC:TermGenie] synonym: "scopolamine catabolism" EXACT [GOC:TermGenie] synonym: "scopolamine degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1900989 ! scopolamine metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -481829,7 +479343,6 @@ synonym: "regulation of L-glutamine uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport is_a: GO:2000485 ! regulation of glutamine transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903803 ! L-glutamine import across plasma membrane relationship: regulates GO:1903803 ! L-glutamine import across plasma membrane @@ -481855,7 +479368,6 @@ is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:2000486 ! negative regulation of glutamine transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1903803 ! L-glutamine import across plasma membrane relationship: negatively_regulates GO:1903803 ! L-glutamine import across plasma membrane @@ -481881,7 +479393,6 @@ is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:2000487 ! positive regulation of glutamine transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1903803 ! L-glutamine import across plasma membrane relationship: positively_regulates GO:1903803 ! L-glutamine import across plasma membrane @@ -482103,7 +479614,7 @@ name: atropine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303] synonym: "atropine metabolism" EXACT [GOC:TermGenie] -is_a: GO:0017144 ! drug metabolic process +is_a: GO:0008152 ! metabolic process created_by: yaf creation_date: 2012-06-28T04:51:25Z @@ -482115,7 +479626,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of atropine synonym: "atropine breakdown" EXACT [GOC:TermGenie] synonym: "atropine catabolism" EXACT [GOC:TermGenie] synonym: "atropine degradation" EXACT [GOC:TermGenie] -is_a: GO:0042737 ! drug catabolic process +is_a: GO:0009056 ! catabolic process is_a: GO:1901049 ! atropine metabolic process created_by: yaf creation_date: 2012-06-28T04:51:51Z @@ -482341,7 +479852,6 @@ synonym: "ferulate catabolism" EXACT [GOC:TermGenie] synonym: "ferulate degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0033494 ! ferulate metabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901502 ! ether catabolic process created_by: tt @@ -482678,7 +480188,6 @@ synonym: "penicillin G catabolic process" EXACT [] synonym: "penicillin G catabolism" EXACT [] synonym: "penicillin G degradation" EXACT [] is_a: GO:0042317 ! penicillin catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901086 ! benzylpenicillin metabolic process created_by: yaf creation_date: 2012-07-05T10:28:59Z @@ -483079,7 +480588,6 @@ name: tetracenomycin C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174] synonym: "tetracenomycin C metabolism" EXACT [GOC:TermGenie] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process @@ -483094,7 +480602,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of tetracen synonym: "tetracenomycin C breakdown" EXACT [GOC:TermGenie] synonym: "tetracenomycin C catabolism" EXACT [GOC:TermGenie] synonym: "tetracenomycin C degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046164 ! alcohol catabolic process @@ -483111,7 +480618,6 @@ synonym: "tetracenomycin C anabolism" EXACT [GOC:TermGenie] synonym: "tetracenomycin C biosynthesis" EXACT [GOC:TermGenie] synonym: "tetracenomycin C formation" EXACT [GOC:TermGenie] synonym: "tetracenomycin C synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1901104 ! tetracenomycin C metabolic process @@ -483125,7 +480631,6 @@ name: granaticin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175] synonym: "granaticin metabolism" EXACT [GOC:TermGenie] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -483141,9 +480646,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of granatic synonym: "granaticin breakdown" EXACT [GOC:TermGenie] synonym: "granaticin catabolism" EXACT [GOC:TermGenie] synonym: "granaticin degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030640 ! polyketide catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901107 ! granaticin metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -483160,7 +480663,6 @@ synonym: "granaticin anabolism" EXACT [GOC:TermGenie] synonym: "granaticin biosynthesis" EXACT [GOC:TermGenie] synonym: "granaticin formation" EXACT [GOC:TermGenie] synonym: "granaticin synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:1901107 ! granaticin metabolic process @@ -483175,7 +480677,6 @@ name: actinorhodin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173] synonym: "actinorhodin metabolism" EXACT [GOC:TermGenie] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process @@ -483192,7 +480693,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of actinorh synonym: "actinorhodin breakdown" EXACT [GOC:TermGenie] synonym: "actinorhodin catabolism" EXACT [GOC:TermGenie] synonym: "actinorhodin degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process @@ -483211,7 +480711,6 @@ synonym: "actinorhodin anabolism" EXACT [GOC:TermGenie] synonym: "actinorhodin biosynthesis" EXACT [GOC:TermGenie] synonym: "actinorhodin formation" EXACT [GOC:TermGenie] synonym: "actinorhodin synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process @@ -483227,7 +480726,6 @@ name: erythromycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240] synonym: "erythromycin metabolism" EXACT [GOC:TermGenie] -is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0033067 ! macrolide metabolic process created_by: yaf @@ -483241,9 +480739,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of erythrom synonym: "erythromycin breakdown" EXACT [GOC:TermGenie] synonym: "erythromycin catabolism" EXACT [GOC:TermGenie] synonym: "erythromycin degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030640 ! polyketide catabolic process -is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:1901113 ! erythromycin metabolic process is_a: GO:1901335 ! lactone catabolic process created_by: yaf @@ -483310,9 +480806,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971] synonym: "tobramycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006807 ! nitrogen compound metabolic process -is_a: GO:0009404 ! toxin metabolic process is_a: GO:0016137 ! glycoside metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0019751 ! polyol metabolic process created_by: yaf creation_date: 2012-07-11T03:15:19Z @@ -483325,11 +480819,8 @@ def: "The chemical reactions and pathways resulting in the breakdown of tobramyc synonym: "tobramycin breakdown" EXACT [GOC:TermGenie] synonym: "tobramycin catabolism" EXACT [GOC:TermGenie] synonym: "tobramycin degradation" EXACT [GOC:TermGenie] -is_a: GO:0009407 ! toxin catabolic process is_a: GO:0016139 ! glycoside catabolic process -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0046174 ! polyol catabolic process -is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:1901119 ! tobramycin metabolic process created_by: yaf creation_date: 2012-07-11T03:15:43Z @@ -483343,9 +480834,7 @@ synonym: "tobramycin anabolism" EXACT [GOC:TermGenie] synonym: "tobramycin biosynthesis" EXACT [GOC:TermGenie] synonym: "tobramycin formation" EXACT [GOC:TermGenie] synonym: "tobramycin synthesis" EXACT [GOC:TermGenie] -is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0016138 ! glycoside biosynthetic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:1901119 ! tobramycin metabolic process created_by: yaf @@ -483358,7 +480847,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179] synonym: "bacitracin A metabolism" EXACT [GOC:TermGenie] is_a: GO:0006518 ! peptide metabolic process -is_a: GO:0016999 ! antibiotic metabolic process created_by: yaf creation_date: 2012-07-11T03:15:56Z @@ -483370,7 +480858,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of bacitrac synonym: "bacitracin A breakdown" EXACT [GOC:TermGenie] synonym: "bacitracin A catabolism" EXACT [GOC:TermGenie] synonym: "bacitracin A degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:1901122 ! bacitracin A metabolic process created_by: yaf @@ -483385,7 +480872,6 @@ synonym: "bacitracin A anabolism" EXACT [GOC:TermGenie] synonym: "bacitracin A biosynthesis" EXACT [GOC:TermGenie] synonym: "bacitracin A formation" EXACT [GOC:TermGenie] synonym: "bacitracin A synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:1901122 ! bacitracin A metabolic process created_by: yaf @@ -483397,7 +480883,6 @@ name: candicidin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101] synonym: "candicidin metabolism" EXACT [GOC:TermGenie] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0071704 ! organic substance metabolic process created_by: yaf creation_date: 2012-07-11T03:16:32Z @@ -483410,8 +480895,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of candicid synonym: "candicidin breakdown" EXACT [GOC:TermGenie] synonym: "candicidin catabolism" EXACT [GOC:TermGenie] synonym: "candicidin degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901125 ! candicidin metabolic process is_a: GO:1901575 ! organic substance catabolic process created_by: yaf @@ -483426,7 +480909,6 @@ synonym: "candicidin anabolism" EXACT [GOC:TermGenie] synonym: "candicidin biosynthesis" EXACT [GOC:TermGenie] synonym: "candicidin formation" EXACT [GOC:TermGenie] synonym: "candicidin synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:1901125 ! candicidin metabolic process is_a: GO:1901576 ! organic substance biosynthetic process created_by: yaf @@ -483699,9 +481181,7 @@ name: salicylic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with salicylic acid." [GOC:TermGenie, PMID:22699612] synonym: "salicylic acid receptor" NARROW [PMID:22699612] -is_a: GO:0008144 ! drug binding is_a: GO:0033293 ! monocarboxylic acid binding -is_a: GO:0042562 ! hormone binding is_a: GO:0097159 ! organic cyclic compound binding created_by: dhl creation_date: 2012-07-16T05:26:38Z @@ -483717,7 +481197,6 @@ synonym: "vistamycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0016137 ! glycoside metabolic process -is_a: GO:0016999 ! antibiotic metabolic process created_by: yaf creation_date: 2012-07-17T04:26:45Z @@ -483734,8 +481213,6 @@ synonym: "vistamycin breakdown" EXACT [GOC:TermGenie] synonym: "vistamycin catabolism" EXACT [GOC:TermGenie] synonym: "vistamycin degradation" EXACT [GOC:TermGenie] is_a: GO:0016139 ! glycoside catabolic process -is_a: GO:0017001 ! antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901150 ! vistamycin metabolic process created_by: yaf @@ -483756,7 +481233,6 @@ synonym: "vistamycin biosynthesis" EXACT [GOC:TermGenie] synonym: "vistamycin formation" EXACT [GOC:TermGenie] synonym: "vistamycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016138 ! glycoside biosynthetic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901150 ! vistamycin metabolic process created_by: yaf @@ -483782,7 +481258,6 @@ synonym: "paromomycin breakdown" EXACT [GOC:TermGenie] synonym: "paromomycin catabolism" EXACT [GOC:TermGenie] synonym: "paromomycin degradation" EXACT [GOC:TermGenie] is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:1901153 ! paromomycin metabolic process created_by: yaf @@ -484012,7 +481487,6 @@ synonym: "naphthalene catabolism" EXACT [GOC:TermGenie] synonym: "naphthalene degradation" EXACT [GOC:TermGenie] is_a: GO:0018931 ! naphthalene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process created_by: yaf creation_date: 2012-07-19T09:33:50Z @@ -484155,7 +481629,8 @@ synonym: "down regulation of cellular response to caffeine" EXACT [GOC:TermGenie synonym: "down-regulation of cellular response to caffeine" EXACT [GOC:TermGenie] synonym: "downregulation of cellular response to caffeine" EXACT [GOC:TermGenie] synonym: "inhibition of cellular response to caffeine" NARROW [GOC:TermGenie] -is_a: GO:2001039 ! negative regulation of cellular response to drug +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0071313 ! cellular response to caffeine relationship: negatively_regulates GO:0071313 ! cellular response to caffeine @@ -485552,7 +483027,6 @@ namespace: molecular_function def: "Enables the transfer of (R)-carnitine from one side of a membrane to the other." [GOC:TermGenie, PMID:16365042, PMID:20357772, PMID:20829798] xref: RHEA:34959 is_a: GO:0015226 ! carnitine transmembrane transporter activity -is_a: GO:0090482 ! vitamin transmembrane transporter activity relationship: part_of GO:1902270 ! (R)-carnitine transmembrane transport created_by: jl creation_date: 2012-08-07T14:46:17Z @@ -486090,7 +483564,6 @@ synonym: "cephalosporin C breakdown" EXACT [GOC:TermGenie] synonym: "cephalosporin C catabolism" EXACT [GOC:TermGenie] synonym: "cephalosporin C degradation" EXACT [GOC:TermGenie] is_a: GO:0030655 ! beta-lactam antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901266 ! cephalosporin C metabolic process @@ -486349,7 +483822,7 @@ synonym: "FeMo-co metabolism" EXACT [GOC:yaf] synonym: "iron-molybdenum cofactor metabolic process" EXACT [GOC:yaf] synonym: "iron-molybdenum cofactor metabolism" EXACT [GOC:yaf] synonym: "iron-sulfur-molybdenum cofactor metabolism" EXACT [GOC:TermGenie] -is_a: GO:0051186 ! cofactor metabolic process +is_a: GO:0008152 ! metabolic process created_by: yaf creation_date: 2012-08-17T15:39:14Z @@ -486369,7 +483842,7 @@ synonym: "iron-molybdenum degradation" EXACT [GOC:yaf] synonym: "iron-sulfur-molybdenum cofactor breakdown" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor catabolism" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor degradation" EXACT [GOC:TermGenie] -is_a: GO:0051187 ! cofactor catabolic process +is_a: GO:0009056 ! catabolic process is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process created_by: yaf creation_date: 2012-08-17T15:39:36Z @@ -486393,7 +483866,7 @@ synonym: "iron-sulfur-molybdenum cofactor anabolism" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor formation" EXACT [GOC:TermGenie] synonym: "iron-sulfur-molybdenum cofactor synthesis" EXACT [GOC:TermGenie] -is_a: GO:0051188 ! cofactor biosynthetic process +is_a: GO:0009058 ! biosynthetic process is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process created_by: yaf creation_date: 2012-08-17T15:39:48Z @@ -486941,7 +484414,7 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie] synonym: "regulation of sperm motility" BROAD [] synonym: "regulation of sperm movement" BROAD [GOC:TermGenie] -is_a: GO:1902019 ! regulation of cilium-dependent cell motility +is_a: GO:0060295 ! regulation of cilium movement involved in cell motility is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0030317 ! flagellated sperm motility @@ -486964,6 +484437,7 @@ synonym: "inhibition of sperm motility" NARROW [GOC:TermGenie] synonym: "inhibition of sperm movement" BROAD [GOC:TermGenie] synonym: "negative regulation of sperm motility" BROAD [] synonym: "negative regulation of sperm movement" BROAD [GOC:TermGenie] +is_a: GO:0003354 ! negative regulation of cilium movement is_a: GO:1901317 ! regulation of flagellated sperm motility is_a: GO:1902020 ! negative regulation of cilium-dependent cell motility is_a: GO:2000242 ! negative regulation of reproductive process @@ -487067,8 +484541,6 @@ name: response to chloramphenicol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: tb creation_date: 2012-08-30T00:01:07Z @@ -487078,9 +484550,7 @@ id: GO:1901323 name: response to erythromycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:TermGenie] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah @@ -487093,8 +484563,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097327 ! response to antineoplastic agent created_by: mah creation_date: 2012-08-30T10:11:07Z @@ -487105,7 +484573,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-08-30T10:12:16Z @@ -487115,8 +484582,6 @@ id: GO:1901326 name: response to tetracycline namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:TermGenie] -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone created_by: mah @@ -487129,7 +484594,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus." [GOC:TermGenie] synonym: "response to FK506" EXACT [CHEBI:61057] synonym: "response to tacrolimus hydrate" EXACT [CHEBI:61057] -is_a: GO:0042493 ! response to drug +is_a: GO:0042221 ! response to chemical created_by: mah creation_date: 2012-08-30T10:14:40Z @@ -487138,10 +484603,8 @@ id: GO:1901328 name: response to cytochalasin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:TermGenie] -is_a: GO:0010046 ! response to mycotoxin is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-08-30T16:36:35Z @@ -487376,7 +484839,6 @@ name: response to leptomycin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:TermGenie] is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0046677 ! response to antibiotic is_a: GO:0070542 ! response to fatty acid created_by: mah creation_date: 2012-09-07T13:20:47Z @@ -487643,7 +485105,6 @@ id: GO:1901354 name: response to L-canavanine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus." [GOC:TermGenie] -is_a: GO:0017085 ! response to insecticide is_a: GO:0043200 ! response to amino acid created_by: mah creation_date: 2012-09-13T13:11:17Z @@ -487656,9 +485117,7 @@ def: "Any process that results in a change in state or activity of a cell or an is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether -is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: mah creation_date: 2012-09-13T13:12:26Z @@ -488916,11 +486375,9 @@ synonym: "regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EX synonym: "regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] synonym: "regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] -is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -488961,7 +486418,6 @@ synonym: "negative regulation of tetrapyrrole synthesis from glycine and succiny is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process @@ -489003,7 +486459,6 @@ synonym: "upregulation of tetrapyrrole synthesis from glycine and succinyl-CoA" is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process @@ -489019,7 +486474,6 @@ name: regulation of response to ethanol namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie] is_a: GO:1901419 ! regulation of response to alcohol -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0045471 ! response to ethanol relationship: regulates GO:0045471 ! response to ethanol @@ -489037,7 +486491,6 @@ synonym: "downregulation of response to ethanol" EXACT [GOC:TermGenie] synonym: "inhibition of response to ethanol" NARROW [GOC:TermGenie] is_a: GO:1901416 ! regulation of response to ethanol is_a: GO:1901420 ! negative regulation of response to alcohol -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045471 ! response to ethanol relationship: negatively_regulates GO:0045471 ! response to ethanol @@ -489055,7 +486508,6 @@ synonym: "up-regulation of response to ethanol" EXACT [GOC:TermGenie] synonym: "upregulation of response to ethanol" EXACT [GOC:TermGenie] is_a: GO:1901416 ! regulation of response to ethanol is_a: GO:1901421 ! positive regulation of response to alcohol -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045471 ! response to ethanol relationship: positively_regulates GO:0045471 ! response to ethanol @@ -489115,7 +486567,6 @@ namespace: biological_process alt_id: GO:1990336 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie, PMID:24014527] synonym: "process resulting in tolerance to butan-1-ol" NARROW [] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0097305 ! response to alcohol [Term] @@ -489132,9 +486583,7 @@ id: GO:1901424 name: response to toluene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toluene stimulus." [GOC:mengo_curators, GOC:TermGenie] -is_a: GO:0009636 ! response to toxic substance is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug created_by: tt creation_date: 2012-10-01T18:38:32Z @@ -489143,10 +486592,7 @@ id: GO:1901425 name: response to formic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formic acid stimulus." [GOC:mengo_curators, GOC:TermGenie] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010033 ! response to organic substance -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: tt creation_date: 2012-10-01T18:43:05Z @@ -489166,7 +486612,6 @@ id: GO:1901427 name: response to propan-1-ol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a propan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0097305 ! response to alcohol created_by: tt creation_date: 2012-10-01T18:55:48Z @@ -489697,7 +487142,7 @@ id: GO:1901454 name: regulation of response to toluene namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie] -is_a: GO:2001023 ! regulation of response to drug +is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901424 ! response to toluene relationship: regulates GO:1901424 ! response to toluene @@ -489713,8 +487158,8 @@ synonym: "down regulation of response to toluene" EXACT [GOC:TermGenie] synonym: "down-regulation of response to toluene" EXACT [GOC:TermGenie] synonym: "downregulation of response to toluene" EXACT [GOC:TermGenie] synonym: "inhibition of response to toluene" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901454 ! regulation of response to toluene -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901424 ! response to toluene relationship: negatively_regulates GO:1901424 ! response to toluene @@ -489730,8 +487175,8 @@ synonym: "activation of response to toluene" NARROW [GOC:TermGenie] synonym: "up regulation of response to toluene" EXACT [GOC:TermGenie] synonym: "up-regulation of response to toluene" EXACT [GOC:TermGenie] synonym: "upregulation of response to toluene" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901454 ! regulation of response to toluene -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901424 ! response to toluene relationship: positively_regulates GO:1901424 ! response to toluene @@ -489789,7 +487234,7 @@ id: GO:1901460 name: regulation of response to formic acid namespace: biological_process def: "Any process that modulates the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie] -is_a: GO:2001023 ! regulation of response to drug +is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1901425 ! response to formic acid relationship: regulates GO:1901425 ! response to formic acid @@ -489805,8 +487250,8 @@ synonym: "down regulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "down-regulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "downregulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "inhibition of response to formic acid" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:1901460 ! regulation of response to formic acid -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1901425 ! response to formic acid relationship: negatively_regulates GO:1901425 ! response to formic acid @@ -489822,8 +487267,8 @@ synonym: "activation of response to formic acid" NARROW [GOC:TermGenie] synonym: "up regulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "up-regulation of response to formic acid" EXACT [GOC:TermGenie] synonym: "upregulation of response to formic acid" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:1901460 ! regulation of response to formic acid -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1901425 ! response to formic acid relationship: positively_regulates GO:1901425 ! response to formic acid @@ -490139,8 +487584,8 @@ namespace: biological_process def: "The directed movement of benomyl across a membrane." [GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "benomyl membrane transport" EXACT [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015900 ! benomyl transport +is_a: GO:0055085 ! transmembrane transport created_by: tb creation_date: 2012-10-04T23:11:36Z @@ -490511,7 +487956,6 @@ id: GO:1901499 name: response to hexane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexane stimulus." [GOC:mengo_curators, GOC:TermGenie] -is_a: GO:0009636 ! response to toxic substance is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2012-10-16T15:14:49Z @@ -490944,7 +488388,6 @@ name: response to hypochlorite namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hypochlorite stimulus." [GOC:pr, GOC:TermGenie, PMID:22223481] is_a: GO:0000302 ! response to reactive oxygen species -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance created_by: pr creation_date: 2012-10-24T07:12:21Z @@ -491381,10 +488824,8 @@ name: response to paracetamol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paracetamol stimulus." [GOC:TermGenie] synonym: "response to acetaminophen" EXACT [] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2012-11-02T09:43:23Z @@ -491395,7 +488836,6 @@ name: response to paclitaxel namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GOC:TermGenie] is_a: GO:0033993 ! response to lipid -is_a: GO:0097327 ! response to antineoplastic agent created_by: hp creation_date: 2012-11-02T09:46:08Z @@ -491404,11 +488844,8 @@ id: GO:1901556 name: response to candesartan namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a candesartan stimulus." [GOC:TermGenie] -is_a: GO:0001101 ! response to acid chemical -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2012-11-02T09:46:13Z @@ -491418,9 +488855,7 @@ id: GO:1901557 name: response to fenofibrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus." [GOC:TermGenie] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug is_a: GO:0045472 ! response to ether is_a: GO:1901654 ! response to ketone created_by: hp @@ -491431,9 +488866,7 @@ id: GO:1901558 name: response to metformin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus." [GOC:TermGenie] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound -is_a: GO:0042493 ! response to drug created_by: hp creation_date: 2012-11-02T09:46:24Z @@ -491444,9 +488877,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ribavirin stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug -is_a: GO:0061479 ! response to reverse transcriptase inhibitor -is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2012-11-02T09:46:28Z @@ -491467,8 +488897,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug -is_a: GO:0060992 ! response to fungicide is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-11-02T15:32:33Z @@ -491478,7 +488906,6 @@ id: GO:1901562 name: response to paraquat namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:TermGenie] -is_a: GO:0009635 ! response to herbicide is_a: GO:0010033 ! response to organic substance created_by: mah creation_date: 2012-11-02T15:32:41Z @@ -491492,7 +488919,6 @@ synonym: "response to CPT" EXACT [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid is_a: GO:0097305 ! response to alcohol -is_a: GO:0097327 ! response to antineoplastic agent created_by: mah creation_date: 2012-11-02T15:32:45Z @@ -491959,7 +489385,6 @@ id: GO:1901593 name: response to GW 7647 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:TermGenie] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010033 ! response to organic substance is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound @@ -491994,7 +489419,6 @@ name: response to reversine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:TermGenie] is_a: GO:0014074 ! response to purine-containing compound -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-11-07T17:17:01Z @@ -492006,8 +489430,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug -is_a: GO:0060992 ! response to fungicide is_a: GO:1901700 ! response to oxygen-containing compound created_by: mah creation_date: 2012-11-07T17:17:06Z @@ -492050,7 +489472,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving strigolactone." [GOC:TermGenie] synonym: "strigolactone metabolism" EXACT [GOC:TermGenie] is_a: GO:0006714 ! sesquiterpenoid metabolic process -is_a: GO:0042445 ! hormone metabolic process is_a: GO:1901334 ! lactone metabolic process created_by: tb creation_date: 2012-11-08T01:20:09Z @@ -492065,7 +489486,6 @@ synonym: "strigolactone biosynthesis" EXACT [GOC:TermGenie] synonym: "strigolactone formation" EXACT [GOC:TermGenie] synonym: "strigolactone synthesis" EXACT [GOC:TermGenie] is_a: GO:0016106 ! sesquiterpenoid biosynthetic process -is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:1901336 ! lactone biosynthetic process is_a: GO:1901600 ! strigolactone metabolic process created_by: tb @@ -493026,7 +490446,6 @@ synonym: "quinone cofactor metabolic process" RELATED [] synonym: "quinone cofactor metabolism" RELATED [] synonym: "quinone metabolism" EXACT [GOC:TermGenie] is_a: GO:0042180 ! cellular ketone metabolic process -is_a: GO:0051186 ! cofactor metabolic process created_by: pr creation_date: 2012-11-20T14:44:39Z @@ -493043,7 +490462,6 @@ synonym: "quinone cofactor catabolic process" RELATED [] synonym: "quinone cofactor catabolism" RELATED [] synonym: "quinone cofactor degradation" RELATED [] synonym: "quinone degradation" EXACT [GOC:TermGenie] -is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:1901661 ! quinone metabolic process created_by: pr @@ -493064,7 +490482,6 @@ synonym: "quinone cofactor formation" RELATED [] synonym: "quinone cofactor synthesis" RELATED [] synonym: "quinone formation" EXACT [GOC:TermGenie] synonym: "quinone synthesis" EXACT [GOC:TermGenie] -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:1901661 ! quinone metabolic process created_by: pr @@ -493865,7 +491282,6 @@ synonym: "tyramine anabolism" EXACT [GOC:TermGenie] synonym: "tyramine biosynthesis" EXACT [GOC:TermGenie] synonym: "tyramine formation" EXACT [GOC:TermGenie] synonym: "tyramine synthesis" EXACT [GOC:TermGenie] -is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901162 ! primary amino compound biosynthetic process created_by: tb @@ -493976,7 +491392,6 @@ synonym: "L-glutamine biosynthesis" EXACT [GOC:TermGenie] synonym: "L-glutamine formation" EXACT [GOC:TermGenie] synonym: "L-glutamine synthesis" EXACT [GOC:TermGenie] is_a: GO:0006542 ! glutamine biosynthetic process -is_a: GO:0017144 ! drug metabolic process created_by: pde creation_date: 2012-12-13T23:32:52Z @@ -494038,7 +491453,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving (+)-larreatricin." [GOC:TermGenie, pmid:12960376] synonym: "(+)-larreatricin metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process created_by: ms @@ -494226,7 +491640,6 @@ synonym: "regulation of GABA catabolism" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] synonym: "regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] -is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0008150 ! biological_process @@ -494559,7 +491972,6 @@ def: "The chemical reactions and pathways involving monensin A." [GOC:TermGenie, synonym: "monensin A metabolism" EXACT [GOC:TermGenie] synonym: "monensin metabolism" EXACT [GOC:yaf] is_a: GO:0006066 ! alcohol metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -494577,8 +491989,6 @@ synonym: "monensin A degradation" EXACT [GOC:TermGenie] synonym: "monensin breakdown" EXACT [GOC:yaf] synonym: "monensin catabolism" EXACT [GOC:yaf] synonym: "monensin degradation" EXACT [GOC:yaf] -is_a: GO:0017001 ! antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process @@ -494600,7 +492010,6 @@ synonym: "monensin anabolism" EXACT [GOC:yaf] synonym: "monensin biosynthesis" EXACT [GOC:yaf] synonym: "monensin formation" EXACT [GOC:yaf] synonym: "monensin synthesis" EXACT [GOC:yaf] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process @@ -494643,8 +492052,6 @@ name: quercetin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724] synonym: "quercetin metabolism" EXACT [GOC:TermGenie] -is_a: GO:0016999 ! antibiotic metabolic process -is_a: GO:0042445 ! hormone metabolic process is_a: GO:0051552 ! flavone metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process created_by: yaf @@ -494658,9 +492065,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of querceti synonym: "quercetin breakdown" EXACT [GOC:TermGenie] synonym: "quercetin catabolism" EXACT [GOC:TermGenie] synonym: "quercetin degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process -is_a: GO:0042447 ! hormone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046275 ! flavonoid catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process is_a: GO:1901732 ! quercetin metabolic process @@ -494676,8 +492080,6 @@ synonym: "quercetin anabolism" EXACT [GOC:TermGenie] synonym: "quercetin biosynthesis" EXACT [GOC:TermGenie] synonym: "quercetin formation" EXACT [GOC:TermGenie] synonym: "quercetin synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process -is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0051553 ! flavone biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process is_a: GO:1901732 ! quercetin metabolic process @@ -494801,7 +492203,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf] synonym: "2-deoxystreptamine metabolism" EXACT [GOC:TermGenie] is_a: GO:0006807 ! nitrogen compound metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0019751 ! polyol metabolic process created_by: yaf creation_date: 2013-01-14T10:01:57Z @@ -494814,7 +492215,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of 2-deoxys synonym: "2-deoxystreptamine breakdown" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine catabolism" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0046174 ! polyol catabolic process is_a: GO:1901742 ! 2-deoxystreptamine metabolic process created_by: yaf @@ -494829,7 +492229,6 @@ synonym: "2-deoxystreptamine anabolism" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine biosynthesis" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine formation" EXACT [GOC:TermGenie] synonym: "2-deoxystreptamine synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:1901742 ! 2-deoxystreptamine metabolic process created_by: yaf @@ -494889,7 +492288,6 @@ synonym: "leukotriene D4 metabolism" EXACT [GOC:TermGenie] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006691 ! leukotriene metabolic process is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0017144 ! drug metabolic process created_by: yaf creation_date: 2013-01-14T10:56:12Z @@ -494902,7 +492300,6 @@ synonym: "leukotriene D4 breakdown" EXACT [GOC:TermGenie] synonym: "leukotriene D4 catabolism" EXACT [GOC:TermGenie] synonym: "leukotriene D4 degradation" EXACT [GOC:TermGenie] is_a: GO:0036100 ! leukotriene catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901748 ! leukotriene D4 metabolic process @@ -494991,7 +492388,6 @@ synonym: "vitamin D3 breakdown" EXACT [GOC:yaf] synonym: "vitamin D3 catabolism" EXACT [GOC:yaf] synonym: "vitamin D3 degradation" EXACT [GOC:yaf] is_a: GO:0042369 ! vitamin D catabolic process -is_a: GO:0042447 ! hormone catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0070640 ! vitamin D3 metabolic process created_by: yaf @@ -495015,7 +492411,6 @@ synonym: "vitamin D3 formation" EXACT [GOC:yaf] synonym: "vitamin D3 synthesis" EXACT [GOC:yaf] is_a: GO:0042368 ! vitamin D biosynthetic process is_a: GO:0070640 ! vitamin D3 metabolic process -is_a: GO:0120178 ! steroid hormone biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process created_by: yaf creation_date: 2013-01-14T11:11:09Z @@ -495098,7 +492493,6 @@ name: oxytetracycline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168] synonym: "oxytetracycline metabolism" EXACT [GOC:TermGenie] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process created_by: yaf creation_date: 2013-01-15T09:52:50Z @@ -495111,9 +492505,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of oxytetra synonym: "oxytetracycline breakdown" EXACT [GOC:TermGenie] synonym: "oxytetracycline catabolism" EXACT [GOC:TermGenie] synonym: "oxytetracycline degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030640 ! polyketide catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901761 ! oxytetracycline metabolic process created_by: yaf creation_date: 2013-01-15T09:52:55Z @@ -495127,7 +492519,6 @@ synonym: "oxytetracycline anabolism" EXACT [GOC:TermGenie] synonym: "oxytetracycline biosynthesis" EXACT [GOC:TermGenie] synonym: "oxytetracycline formation" EXACT [GOC:TermGenie] synonym: "oxytetracycline synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:1901761 ! oxytetracycline metabolic process created_by: yaf @@ -495218,7 +492609,6 @@ synonym: "daunorubicin degradation" EXACT [GOC:TermGenie] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0044597 ! daunorubicin metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901662 ! quinone catabolic process @@ -495251,7 +492641,6 @@ def: "The chemical reactions and pathways involving lincomycin." [GOC:TermGenie, synonym: "lincomycin metabolism" EXACT [GOC:TermGenie] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0016143 ! S-glycoside metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -495267,7 +492656,6 @@ synonym: "lincomycin breakdown" EXACT [GOC:TermGenie] synonym: "lincomycin catabolism" EXACT [GOC:TermGenie] synonym: "lincomycin degradation" EXACT [GOC:TermGenie] is_a: GO:0016145 ! S-glycoside catabolic process -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -495285,7 +492673,6 @@ synonym: "lincomycin biosynthesis" EXACT [GOC:TermGenie] synonym: "lincomycin formation" EXACT [GOC:TermGenie] synonym: "lincomycin synthesis" EXACT [GOC:TermGenie] is_a: GO:0016144 ! S-glycoside biosynthetic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process @@ -495300,7 +492687,6 @@ name: mitomycin C metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135] synonym: "mitomycin C metabolism" EXACT [GOC:TermGenie] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process @@ -495316,7 +492702,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of mitomyci synonym: "mitomycin C breakdown" EXACT [GOC:TermGenie] synonym: "mitomycin C catabolism" EXACT [GOC:TermGenie] synonym: "mitomycin C degradation" EXACT [GOC:TermGenie] -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process @@ -495349,7 +492734,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094] synonym: "pentalenolactone metabolism" EXACT [GOC:TermGenie] is_a: GO:0006714 ! sesquiterpenoid metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0097176 ! epoxide metabolic process is_a: GO:1901334 ! lactone metabolic process @@ -495365,7 +492749,6 @@ synonym: "pentalenolactone breakdown" EXACT [GOC:TermGenie] synonym: "pentalenolactone catabolism" EXACT [GOC:TermGenie] synonym: "pentalenolactone degradation" EXACT [GOC:TermGenie] is_a: GO:0016107 ! sesquiterpenoid catabolic process -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901335 ! lactone catabolic process is_a: GO:1901502 ! ether catabolic process @@ -495383,7 +492766,6 @@ synonym: "pentalenolactone biosynthesis" EXACT [GOC:TermGenie] synonym: "pentalenolactone formation" EXACT [GOC:TermGenie] synonym: "pentalenolactone synthesis" EXACT [GOC:TermGenie] is_a: GO:0016106 ! sesquiterpenoid biosynthetic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901336 ! lactone biosynthetic process is_a: GO:1901503 ! ether biosynthetic process @@ -495439,7 +492821,6 @@ name: p-cresol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531] synonym: "p-cresol metabolism" EXACT [GOC:TermGenie] -is_a: GO:0009404 ! toxin metabolic process is_a: GO:0042212 ! cresol metabolic process created_by: yaf creation_date: 2013-01-16T11:03:59Z @@ -495452,7 +492833,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of p-cresol synonym: "p-cresol breakdown" EXACT [GOC:TermGenie] synonym: "p-cresol catabolism" EXACT [GOC:TermGenie] synonym: "p-cresol degradation" EXACT [GOC:TermGenie] -is_a: GO:0009407 ! toxin catabolic process is_a: GO:0046199 ! cresol catabolic process is_a: GO:1901784 ! p-cresol metabolic process created_by: yaf @@ -495467,8 +492847,6 @@ synonym: "p-cresol anabolism" EXACT [GOC:TermGenie] synonym: "p-cresol biosynthesis" EXACT [GOC:TermGenie] synonym: "p-cresol formation" EXACT [GOC:TermGenie] synonym: "p-cresol synthesis" EXACT [GOC:TermGenie] -is_a: GO:0009403 ! toxin biosynthetic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901784 ! p-cresol metabolic process created_by: yaf @@ -495520,6 +492898,7 @@ name: 3-(2,3-dihydroxyphenyl)propanoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY] synonym: "3-(2,3-dihydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process created_by: yaf creation_date: 2013-01-16T11:40:57Z @@ -495532,6 +492911,7 @@ def: "The chemical reactions and pathways resulting in the breakdown of 3-(2,3-d synonym: "3-(2,3-dihydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie] +is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process created_by: yaf @@ -495546,6 +492926,7 @@ synonym: "3-(2,3-dihydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie] synonym: "3-(2,3-dihydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process created_by: yaf @@ -495859,7 +493240,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387] synonym: "astaxanthin metabolism" EXACT [GOC:TermGenie] is_a: GO:0016122 ! xanthophyll metabolic process -is_a: GO:0017144 ! drug metabolic process created_by: yaf creation_date: 2013-01-22T10:36:59Z @@ -495872,7 +493252,6 @@ synonym: "astaxanthin breakdown" EXACT [GOC:TermGenie] synonym: "astaxanthin catabolism" EXACT [GOC:TermGenie] synonym: "astaxanthin degradation" EXACT [GOC:TermGenie] is_a: GO:0016124 ! xanthophyll catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:1901813 ! astaxanthin metabolic process created_by: yaf creation_date: 2013-01-22T10:37:03Z @@ -496405,9 +493784,7 @@ namespace: biological_process def: "The chemical reactions and pathways involving nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830] synonym: "nicotinate metabolism" EXACT [GOC:TermGenie] is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009820 ! alkaloid metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process created_by: yaf @@ -496423,8 +493800,6 @@ synonym: "nicotinate catabolism" EXACT [GOC:TermGenie] synonym: "nicotinate degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0019439 ! aromatic compound catabolic process -is_a: GO:0042365 ! water-soluble vitamin catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process is_a: GO:1901847 ! nicotinate metabolic process @@ -496442,7 +493817,6 @@ synonym: "nicotinate formation" EXACT [GOC:TermGenie] synonym: "nicotinate synthesis" EXACT [GOC:TermGenie] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process -is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process is_a: GO:1901847 ! nicotinate metabolic process @@ -496457,7 +493831,6 @@ def: "The chemical reactions and pathways involving 7,8-didemethyl-8-hydroxy-5-d synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolism" EXACT [GOC:TermGenie] synonym: "coenzyme F0 metabolism" EXACT [GOC:yaf] is_a: GO:0046483 ! heterocycle metabolic process -is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process created_by: yaf @@ -496476,7 +493849,6 @@ synonym: "coenzyme F0 catabolic process" EXACT [GOC:yaf] synonym: "coenzyme F0 catabolism" EXACT [GOC:yaf] synonym: "coenzyme F0 degradation" EXACT [GOC:yaf] is_a: GO:0046700 ! heterocycle catabolic process -is_a: GO:0051187 ! cofactor catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process @@ -496498,7 +493870,6 @@ synonym: "coenzyme F0 biosynthetic process" EXACT [GOC:yaf] synonym: "coenzyme F0 formation" EXACT [GOC:yaf] synonym: "coenzyme F0 synthesis" EXACT [GOC:yaf] is_a: GO:0018130 ! heterocycle biosynthetic process -is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process @@ -496781,7 +494152,6 @@ name: ecgonine methyl ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecgonine methyl ester." [GOC:TermGenie, PMID:22665766] synonym: "ecgonine methyl ester metabolism" EXACT [GOC:TermGenie] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0046448 ! tropane alkaloid metabolic process created_by: ms creation_date: 2013-02-04T11:58:14Z @@ -496795,7 +494165,6 @@ synonym: "ecgonine methyl ester breakdown" EXACT [GOC:TermGenie] synonym: "ecgonine methyl ester catabolism" EXACT [GOC:TermGenie] synonym: "ecgonine methyl ester degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901867 ! ecgonine methyl ester metabolic process @@ -497594,7 +494963,6 @@ def: "Any process that results in a change in state or activity of a cell or an is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0014075 ! response to amine is_a: GO:0045472 ! response to ether -is_a: GO:0097327 ! response to antineoplastic agent created_by: hp creation_date: 2013-02-13T10:14:41Z @@ -498439,8 +495807,8 @@ namespace: biological_process def: "The directed movement of S-adenosyl-L-methionine across a membrane." [GOC:TermGenie, PMID:10497160] synonym: "S-adenosylmethionine transmembrane transport" EXACT [] synonym: "SAM transmembrane transport" EXACT [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015805 ! S-adenosyl-L-methionine transport +is_a: GO:0055085 ! transmembrane transport created_by: jl creation_date: 2013-02-20T14:45:08Z @@ -498853,11 +496221,8 @@ id: GO:1901986 name: response to ketamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus." [GOC:TermGenie, PMID:11251190] -is_a: GO:0009410 ! response to xenobiotic stimulus -is_a: GO:0009636 ! response to toxic substance is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0072347 ! response to anesthetic is_a: GO:1901654 ! response to ketone created_by: dph creation_date: 2013-03-15T19:16:35Z @@ -499504,7 +496869,6 @@ namespace: biological_process def: "The directed movement of a L-lysine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0006812 ! cation transport is_a: GO:0015807 ! L-amino acid transport -is_a: GO:0015893 ! drug transport created_by: kmv creation_date: 2013-03-27T16:09:06Z @@ -499518,7 +496882,6 @@ synonym: "L-arginine import" NARROW [] synonym: "L-arginine uptake" NARROW [] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015809 ! arginine transport -is_a: GO:0015893 ! drug transport created_by: kmv creation_date: 2013-03-27T16:09:11Z @@ -499529,7 +496892,6 @@ namespace: biological_process def: "The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015817 ! histidine transport -is_a: GO:0015893 ! drug transport created_by: kmv creation_date: 2013-03-27T16:09:15Z @@ -500088,7 +497450,6 @@ name: neosartoricin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997] synonym: "neosartoricin metabolism" EXACT [GOC:TermGenie] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0042180 ! cellular ketone metabolic process @@ -500108,7 +497469,6 @@ synonym: "neosartoricin degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0030640 ! polyketide catabolic process is_a: GO:0042182 ! ketone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:1902048 ! neosartoricin metabolic process created_by: di @@ -500254,7 +497614,6 @@ synonym: "(25S)-Delta(7)-dafachronate metabolism" EXACT [GOC:TermGenie] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process -is_a: GO:0042445 ! hormone metabolic process created_by: ab creation_date: 2013-04-13T09:05:27Z @@ -500267,7 +497626,6 @@ synonym: "(25S)-Delta(4)-dafachronate metabolism" EXACT [GOC:TermGenie] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process -is_a: GO:0042445 ! hormone metabolic process created_by: ab creation_date: 2013-04-13T09:22:54Z @@ -500431,8 +497789,6 @@ id: GO:1902065 name: response to L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus." [GOC:TermGenie, PMID:23574009] -is_a: GO:0007584 ! response to nutrient -is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: tb creation_date: 2013-04-16T21:21:14Z @@ -500446,7 +497802,6 @@ synonym: "regulation of cell wall pectin metabolism" EXACT [GOC:TermGenie] synonym: "regulation of cellulose and pectin-containing cell wall pectin metabolic process" EXACT [GOC:TermGenie] synonym: "regulation of pectin metabolism during cell wall biogenesis" EXACT [GOC:TermGenie] synonym: "regulation of plant-type cell wall pectin metabolic process" EXACT [GOC:TermGenie] -is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:1903338 ! regulation of cell wall organization or biogenesis @@ -500748,7 +498103,6 @@ name: fumagillin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861] synonym: "fumagillin metabolism" EXACT [GOC:TermGenie] -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0097176 ! epoxide metabolic process created_by: di @@ -500762,8 +498116,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of fumagill synonym: "fumagillin breakdown" EXACT [GOC:TermGenie] synonym: "fumagillin catabolism" EXACT [GOC:TermGenie] synonym: "fumagillin degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process @@ -500781,7 +498133,6 @@ synonym: "fumagillin anabolism" EXACT [GOC:TermGenie] synonym: "fumagillin biosynthesis" EXACT [GOC:TermGenie] synonym: "fumagillin formation" EXACT [GOC:TermGenie] synonym: "fumagillin synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process @@ -500940,6 +498291,7 @@ synonym: "up-regulation of sperm motility" BROAD [GOC:TermGenie] synonym: "up-regulation of sperm movement" BROAD [GOC:TermGenie] synonym: "upregulation of sperm motility" BROAD [GOC:TermGenie] synonym: "upregulation of sperm movement" BROAD [GOC:TermGenie] +is_a: GO:0003353 ! positive regulation of cilium movement is_a: GO:1901317 ! regulation of flagellated sperm motility is_a: GO:2000155 ! positive regulation of cilium-dependent cell motility is_a: GO:2000243 ! positive regulation of reproductive process @@ -501042,8 +498394,6 @@ synonym: "1alpha,25(OH)2D3 binding" EXACT [CHEBI:17823] synonym: "1alpha,25-dihydroxycholecalciferol binding" EXACT [CHEBI:17823] synonym: "1alpha,25-dihydroxyvitamin D3 binding" EXACT [CHEBI:17823] synonym: "hormonally active vitamin D3 binding" EXACT [GOC:bf] -is_a: GO:0008144 ! drug binding -is_a: GO:0042562 ! hormone binding is_a: GO:1902271 ! D3 vitamins binding created_by: bf creation_date: 2013-05-02T09:41:15Z @@ -501452,7 +498802,6 @@ synonym: "25-hydroxycholecalciferol binding" EXACT [CHEBI:17933] synonym: "25-hydroxyvitamin D3 binding" EXACT [CHEBI:17933] synonym: "25OHD3 binding" EXACT [PMID:11799400] synonym: "calcifediol binding" EXACT [CHEBI:17933] -is_a: GO:0008144 ! drug binding is_a: GO:1902271 ! D3 vitamins binding created_by: bf creation_date: 2013-05-15T14:55:58Z @@ -501501,7 +498850,6 @@ name: lithocholic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lithocholic acid." [GOC:bf, GOC:TermGenie, PMID:20371703] synonym: "LCA binding" EXACT [PMID:20371703] -is_a: GO:0005496 ! steroid binding is_a: GO:0032052 ! bile acid binding created_by: bf creation_date: 2013-05-15T16:05:12Z @@ -501512,7 +498860,6 @@ name: chenodeoxycholic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with chenodeoxycholic acid." [GOC:bf, GOC:TermGenie, PMID:10334992] synonym: "CDCA binding" EXACT [CHEBI:16755] -is_a: GO:0005496 ! steroid binding is_a: GO:0032052 ! bile acid binding created_by: bf creation_date: 2013-05-16T09:17:19Z @@ -501540,10 +498887,8 @@ namespace: biological_process def: "The chemical reactions and pathways involving (+)-pinoresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] synonym: "(+)-pinoresinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process -is_a: GO:0042445 ! hormone metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process created_by: ms @@ -501558,8 +498903,6 @@ synonym: "(+)-pinoresinol breakdown" EXACT [GOC:TermGenie] synonym: "(+)-pinoresinol catabolism" EXACT [GOC:TermGenie] synonym: "(+)-pinoresinol degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process -is_a: GO:0042447 ! hormone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046273 ! lignan catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901502 ! ether catabolic process @@ -501578,7 +498921,6 @@ synonym: "(+)-pinoresinol formation" EXACT [GOC:TermGenie] synonym: "(+)-pinoresinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process -is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1902124 ! (+)-pinoresinol metabolic process @@ -501635,7 +498977,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving (+)-lariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] synonym: "(+)-lariciresinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0034308 ! primary alcohol metabolic process @@ -501651,7 +498992,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of (+)-lari synonym: "(+)-lariciresinol breakdown" EXACT [GOC:TermGenie] synonym: "(+)-lariciresinol catabolism" EXACT [GOC:TermGenie] synonym: "(+)-lariciresinol degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0046273 ! lignan catabolic process @@ -501671,7 +499011,6 @@ synonym: "(+)-lariciresinol biosynthesis" EXACT [GOC:TermGenie] synonym: "(+)-lariciresinol formation" EXACT [GOC:TermGenie] synonym: "(+)-lariciresinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process @@ -501730,10 +499069,8 @@ namespace: biological_process def: "The chemical reactions and pathways involving (-)-secoisolariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] synonym: "(-)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie] is_a: GO:0009806 ! lignan metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0034311 ! diol metabolic process -is_a: GO:0042445 ! hormone metabolic process created_by: ms creation_date: 2013-05-21T08:50:19Z @@ -501747,8 +499084,6 @@ synonym: "(-)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie] synonym: "(-)-secoisolariciresinol degradation" EXACT [GOC:TermGenie] is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0034313 ! diol catabolic process -is_a: GO:0042447 ! hormone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0046273 ! lignan catabolic process is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process created_by: ms @@ -501765,7 +499100,6 @@ synonym: "(-)-secoisolariciresinol formation" EXACT [GOC:TermGenie] synonym: "(-)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie] is_a: GO:0009807 ! lignan biosynthetic process is_a: GO:0034312 ! diol biosynthetic process -is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process created_by: ms @@ -502477,11 +499811,9 @@ namespace: biological_process def: "The chemical reactions and pathways involving verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274] synonym: "verruculogen metabolism" EXACT [GOC:TermGenie] is_a: GO:0006725 ! cellular aromatic compound metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0034311 ! diol metabolic process is_a: GO:0035834 ! indole alkaloid metabolic process -is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process created_by: di @@ -502498,10 +499830,7 @@ synonym: "verruculogen degradation" EXACT [GOC:TermGenie] is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0034313 ! diol catabolic process -is_a: GO:0042737 ! drug catabolic process -is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0046700 ! heterocycle catabolic process -is_a: GO:0051410 ! detoxification of nitrogen compound is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process is_a: GO:1902179 ! verruculogen metabolic process @@ -502519,9 +499848,9 @@ synonym: "verruculogen formation" EXACT [GOC:TermGenie] synonym: "verruculogen synthesis" EXACT [GOC:TermGenie] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0019748 ! secondary metabolic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0035835 ! indole alkaloid biosynthetic process -is_a: GO:0043386 ! mycotoxin biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process is_a: GO:1902179 ! verruculogen metabolic process @@ -503329,7 +500658,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving ketone body." [GOC:pr, GOC:TermGenie] synonym: "ketone body metabolism" EXACT [GOC:TermGenie] is_a: GO:0006091 ! generation of precursor metabolites and energy -is_a: GO:0017144 ! drug metabolic process is_a: GO:1901568 ! fatty acid derivative metabolic process created_by: pr creation_date: 2013-06-13T10:37:54Z @@ -504228,8 +501556,6 @@ id: GO:1902270 name: (R)-carnitine transmembrane transport namespace: biological_process def: "The process in which (R)-carnitine is transported across a membrane." [GOC:TermGenie, PMID:23755272] -is_a: GO:0006855 ! drug transmembrane transport -is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:1900749 ! (R)-carnitine transport is_a: GO:1902603 ! carnitine transmembrane transport created_by: mcc @@ -504250,7 +501576,6 @@ name: regulation of (R)-carnitine transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272] is_a: GO:1904062 ! regulation of cation transmembrane transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1902270 ! (R)-carnitine transmembrane transport relationship: regulates GO:1902270 ! (R)-carnitine transmembrane transport @@ -504268,7 +501593,6 @@ synonym: "downregulation of (R)-carnitine transmembrane transport" EXACT [GOC:Te synonym: "inhibition of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie] is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport relationship: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport @@ -504286,7 +501610,6 @@ synonym: "up-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:Ter synonym: "upregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport relationship: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport @@ -504920,7 +502243,6 @@ name: hydroquinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with hydroquinone." [GOC:bhm, GOC:TermGenie, pmid:15667223] synonym: "quinol binding" EXACT [] -is_a: GO:0048037 ! cofactor binding is_a: GO:0097159 ! organic cyclic compound binding created_by: bhm creation_date: 2013-07-22T10:10:12Z @@ -505147,7 +502469,6 @@ synonym: "negative regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "negative regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015995 ! chlorophyll biosynthetic process @@ -505185,7 +502506,6 @@ synonym: "upregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie synonym: "upregulation of chlorophyll formation" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll synthesis" EXACT [GOC:TermGenie] is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015995 ! chlorophyll biosynthetic process @@ -505543,7 +502863,6 @@ name: response to strigolactone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171] synonym: "response to strigolactone analog GR24" RELATED [PMID:23893171] -is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound @@ -505556,7 +502875,6 @@ name: cellular response to strigolactone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171] synonym: "cellular response to strigolactone analog GR24" RELATED [PMID:23893171] -is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -505571,8 +502889,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic created_by: kmv creation_date: 2013-08-13T19:29:25Z @@ -505581,8 +502897,6 @@ id: GO:1902350 name: cellular response to chloroquine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1902349 ! response to chloroquine @@ -505594,11 +502908,8 @@ id: GO:1902351 name: response to imidacloprid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an imidacloprid stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0017085 ! response to insecticide -is_a: GO:0042493 ! response to drug created_by: kmv creation_date: 2013-08-13T19:33:15Z @@ -506248,7 +503559,6 @@ name: glycyrrhetinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycyrrhetinate." [GOC:TermGenie, pmid:22128119] synonym: "glycyrrhetinate metabolism" EXACT [GOC:TermGenie] -is_a: GO:0017144 ! drug metabolic process is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process @@ -506266,7 +503576,6 @@ synonym: "glycyrrhetinate catabolism" EXACT [GOC:TermGenie] synonym: "glycyrrhetinate degradation" EXACT [GOC:TermGenie] is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process is_a: GO:0042182 ! ketone catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process is_a: GO:1902384 ! glycyrrhetinate metabolic process @@ -507229,8 +504538,6 @@ id: GO:1902444 name: riboflavin binding namespace: molecular_function def: "Interacting selectively and non-covalently with riboflavin." [GOC:TermGenie, PMID:12083520] -is_a: GO:0008144 ! drug binding -is_a: GO:0019842 ! vitamin binding is_a: GO:0043168 ! anion binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding @@ -507944,10 +505251,11 @@ creation_date: 2013-11-13T16:22:49Z [Term] id: GO:1902497 -name: iron-sulfur cluster transport +name: iron-sulfur cluster transmembrane transport namespace: biological_process -def: "The directed movement of an iron-sulfur cluster into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:19810706] -is_a: GO:0051181 ! cofactor transport +def: "A process in which an iron-sulfur cluster is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:19810706] +synonym: "iron-sulfur cluster transport" BROAD [] +is_a: GO:0034755 ! iron ion transmembrane transport is_a: GO:1901678 ! iron coordination entity transport created_by: dph creation_date: 2013-11-13T16:33:00Z @@ -508316,9 +505624,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010243 ! response to organonitrogen compound -is_a: GO:0097327 ! response to antineoplastic agent created_by: dw creation_date: 2013-12-02T09:34:08Z @@ -508331,7 +505637,6 @@ comment: Note that this term is in the subset of terms that should not be used f subset: gocheck_do_not_manually_annotate synonym: "response to docetaxel" RELATED [] is_a: GO:0097305 ! response to alcohol -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: dw creation_date: 2013-12-02T09:44:04Z @@ -508344,7 +505649,6 @@ def: "Any process that results in a change in state or activity of a cell or an comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone is_a: GO:1901698 ! response to nitrogen compound @@ -508360,7 +505664,6 @@ def: "Any process that results in a change in state or activity of a cell or an comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1904631 ! response to glucoside created_by: dw creation_date: 2013-12-02T09:44:22Z @@ -508373,9 +505676,7 @@ def: "Any process that results in a change in state or activity of a cell or an comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to epirubicin" RELATED [] -is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1903416 ! response to glycoside @@ -509663,7 +506964,6 @@ alt_id: GO:0015906 def: "The directed movement of sulfathiazole across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "sulfathiazole transport" BROAD [] synonym: "sulphathiazole transport" BROAD [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0042886 ! amide transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:0072348 ! sulfur compound transport @@ -509958,7 +507258,6 @@ id: GO:1902617 name: response to fluoride namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance created_by: kmv creation_date: 2014-01-10T19:41:49Z @@ -509968,7 +507267,7 @@ id: GO:1902618 name: cellular response to fluoride namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152] -is_a: GO:0071229 ! cellular response to acid chemical +is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1902617 ! response to fluoride created_by: kmv creation_date: 2014-01-10T19:41:58Z @@ -510908,7 +508207,7 @@ name: carbon dioxide binding namespace: molecular_function def: "Interacting selectively and non-covalently with carbon dioxide." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:15491402] synonym: "CO2 binding" EXACT [] -is_a: GO:0008144 ! drug binding +is_a: GO:0005488 ! binding created_by: bhm creation_date: 2014-02-04T10:38:41Z @@ -511740,8 +509039,6 @@ name: response to plumbagin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742] is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0061476 ! response to anticoagulant -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: mah creation_date: 2014-02-20T13:49:54Z @@ -511751,7 +509048,6 @@ id: GO:1902709 name: cellular response to plumbagin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901655 ! cellular response to ketone is_a: GO:1902708 ! response to plumbagin @@ -511786,84 +509082,10 @@ def: "A protein complex which is capable of G protein-coupled GABA receptor acti comment: An example of this is GABR1 in human (UniProt symbol Q9UBS5) in PMID:18790874. synonym: "G-protein coupled GABA receptor complex" EXACT [] is_a: GO:0038037 ! G protein-coupled receptor dimeric complex -is_a: GO:0098878 ! neurotransmitter receptor complex is_a: GO:1902710 ! GABA receptor complex created_by: bhm creation_date: 2014-02-21T09:47:03Z -[Term] -id: GO:1902713 -name: regulation of interferon-gamma secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405] -synonym: "regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] -synonym: "regulation of IFNG secretion" EXACT [GOC:TermGenie] -synonym: "regulation of type II IFN secretion" BROAD [GOC:TermGenie] -synonym: "regulation of type II interferon secretion" BROAD [GOC:TermGenie] -is_a: GO:0032649 ! regulation of interferon-gamma production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0072643 ! interferon-gamma secretion -relationship: regulates GO:0072643 ! interferon-gamma secretion -created_by: als -creation_date: 2014-02-21T16:34:19Z - -[Term] -id: GO:1902714 -name: negative regulation of interferon-gamma secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405] -synonym: "down regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of IFNG secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of interferon-gamma secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of IFNG secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of interferon-gamma secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of IFN-gamma secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of IFNG secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of interferon-gamma secretion" EXACT [GOC:TermGenie] -synonym: "inhibition of IFN-gamma secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of IFNG secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of interferon-gamma secretion" NARROW [GOC:TermGenie] -synonym: "negative regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] -synonym: "negative regulation of IFNG secretion" EXACT [GOC:TermGenie] -is_a: GO:0032689 ! negative regulation of interferon-gamma production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:1902713 ! regulation of interferon-gamma secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0072643 ! interferon-gamma secretion -relationship: negatively_regulates GO:0072643 ! interferon-gamma secretion -created_by: als -creation_date: 2014-02-21T16:34:29Z - -[Term] -id: GO:1902715 -name: positive regulation of interferon-gamma secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interferon-gamma secretion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:19109405] -synonym: "activation of IFN-gamma secretion" NARROW [GOC:TermGenie] -synonym: "activation of IFNG secretion" NARROW [GOC:TermGenie] -synonym: "activation of interferon-gamma secretion" NARROW [GOC:TermGenie] -synonym: "positive regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] -synonym: "positive regulation of IFNG secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of IFNG secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of interferon-gamma secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of IFN-gamma secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of IFNG secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of interferon-gamma secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of IFN-gamma secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of IFNG secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of interferon-gamma secretion" EXACT [GOC:TermGenie] -is_a: GO:0032729 ! positive regulation of interferon-gamma production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:1902713 ! regulation of interferon-gamma secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0072643 ! interferon-gamma secretion -relationship: positively_regulates GO:0072643 ! interferon-gamma secretion -created_by: als -creation_date: 2014-02-21T16:34:38Z - [Term] id: GO:1902716 name: cell cortex of growing cell tip @@ -512262,77 +509484,6 @@ relationship: regulates GO:0003413 ! chondrocyte differentiation involved in end created_by: mr creation_date: 2014-02-26T15:36:15Z -[Term] -id: GO:1902739 -name: regulation of interferon-alpha secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501] -synonym: "regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] -synonym: "regulation of IFNA secretion" EXACT [GOC:TermGenie] -is_a: GO:0032647 ! regulation of interferon-alpha production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0072642 ! interferon-alpha secretion -relationship: regulates GO:0072642 ! interferon-alpha secretion -created_by: mr -creation_date: 2014-02-26T22:13:20Z - -[Term] -id: GO:1902740 -name: negative regulation of interferon-alpha secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501] -synonym: "down regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of IFNA secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of interferon-alpha secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of IFNA secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of interferon-alpha secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of IFN-alpha secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of IFNA secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of interferon-alpha secretion" EXACT [GOC:TermGenie] -synonym: "inhibition of IFN-alpha secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of IFNA secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of interferon-alpha secretion" NARROW [GOC:TermGenie] -synonym: "negative regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] -synonym: "negative regulation of IFNA secretion" EXACT [GOC:TermGenie] -is_a: GO:0032687 ! negative regulation of interferon-alpha production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:1902739 ! regulation of interferon-alpha secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0072642 ! interferon-alpha secretion -relationship: negatively_regulates GO:0072642 ! interferon-alpha secretion -created_by: mr -creation_date: 2014-02-26T22:13:30Z - -[Term] -id: GO:1902741 -name: positive regulation of interferon-alpha secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interferon-alpha secretion." [GO_REF:0000058, GOC:TermGenie, PMID:19262501] -synonym: "activation of IFN-alpha secretion" NARROW [GOC:TermGenie] -synonym: "activation of IFNA secretion" NARROW [GOC:TermGenie] -synonym: "activation of interferon-alpha secretion" NARROW [GOC:TermGenie] -synonym: "positive regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] -synonym: "positive regulation of IFNA secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of IFNA secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of interferon-alpha secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of IFN-alpha secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of IFNA secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of interferon-alpha secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of IFN-alpha secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of IFNA secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of interferon-alpha secretion" EXACT [GOC:TermGenie] -is_a: GO:0032727 ! positive regulation of interferon-alpha production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:1902739 ! regulation of interferon-alpha secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0072642 ! interferon-alpha secretion -relationship: positively_regulates GO:0072642 ! interferon-alpha secretion -created_by: mr -creation_date: 2014-02-26T22:13:40Z - [Term] id: GO:1902742 name: apoptotic process involved in development @@ -513042,7 +510193,6 @@ id: GO:1902788 name: response to isooctane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008] -is_a: GO:0009636 ! response to toxic substance is_a: GO:1902778 ! response to alkane created_by: tt creation_date: 2014-03-21T20:52:51Z @@ -513052,7 +510202,6 @@ id: GO:1902789 name: cellular response to isooctane namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008] -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1902779 ! cellular response to alkane is_a: GO:1902788 ! response to isooctane created_by: tt @@ -519702,7 +516851,6 @@ id: GO:1903088 name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport namespace: biological_process def: "The process in which 5-amino-1-ribofuranosylimidazole-4-carboxamide is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24778186] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0042886 ! amide transport is_a: GO:0045117 ! azole transmembrane transport is_a: GO:1901264 ! carbohydrate derivative transport @@ -519727,7 +516875,6 @@ id: GO:1903090 name: pyridoxal transmembrane transport namespace: biological_process def: "The process in which pyridoxal is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0031920 ! pyridoxal transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0098655 ! cation transmembrane transport @@ -519739,7 +516886,6 @@ id: GO:1903091 name: pyridoxamine transmembrane transport namespace: biological_process def: "The process in which pyridoxamine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0031922 ! pyridoxamine transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0098655 ! cation transmembrane transport @@ -519751,7 +516897,6 @@ id: GO:1903092 name: pyridoxine transmembrane transport namespace: biological_process def: "The process in which pyridoxine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0031923 ! pyridoxine transport is_a: GO:0035461 ! vitamin transmembrane transport created_by: al @@ -521020,7 +518165,6 @@ name: response to polycyclic arene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501] is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug created_by: mr creation_date: 2014-07-09T18:32:59Z @@ -521029,7 +518173,6 @@ id: GO:1903166 name: cellular response to polycyclic arene namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1903165 ! response to polycyclic arene created_by: mr @@ -521440,7 +518583,6 @@ def: "The chemical reactions and pathways involving L-dopa." [GO_REF:0000068, GO synonym: "L-dopa metabolism" EXACT [GOC:TermGenie] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process created_by: bf creation_date: 2014-07-14T15:06:00Z @@ -521846,7 +518988,6 @@ synonym: "regulation of cell death in response to hydrogen peroxide" EXACT [GOC: synonym: "regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] is_a: GO:1901031 ! regulation of response to reactive oxygen species is_a: GO:1903201 ! regulation of oxidative stress-induced cell death -is_a: GO:2001038 ! regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036474 ! cell death in response to hydrogen peroxide relationship: regulates GO:0036474 ! cell death in response to hydrogen peroxide @@ -521878,7 +519019,6 @@ synonym: "protection against hydrogen peroxide-induced cell death" RELATED [GOC: is_a: GO:1901032 ! negative regulation of response to reactive oxygen species is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death -is_a: GO:2001039 ! negative regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036474 ! cell death in response to hydrogen peroxide relationship: negatively_regulates GO:0036474 ! cell death in response to hydrogen peroxide @@ -522291,7 +519431,6 @@ name: quinolinic acid transmembrane transport namespace: biological_process def: "The process in which quinolinic acid is transported across a membrane." [GO_REF:0000069, GOC:di, GOC:TermGenie, PMID:23457190] is_a: GO:0006835 ! dicarboxylic acid transport -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1905039 ! carboxylic acid transmembrane transport created_by: di @@ -524397,11 +521536,9 @@ id: GO:1903329 name: regulation of iron-sulfur cluster assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw] -is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization -is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0016226 ! iron-sulfur cluster assembly relationship: regulates GO:0016226 ! iron-sulfur cluster assembly @@ -524427,10 +521564,8 @@ synonym: "inhibition of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie synonym: "inhibition of iron-sulphur cluster assembly" NARROW [GOC:TermGenie] synonym: "negative regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] -is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051175 ! negative regulation of sulfur metabolic process -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0016226 ! iron-sulfur cluster assembly @@ -524457,11 +521592,9 @@ synonym: "up-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] synonym: "upregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] synonym: "upregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] synonym: "upregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] -is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051176 ! positive regulation of sulfur metabolic process -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0016226 ! iron-sulfur cluster assembly @@ -524923,7 +522056,6 @@ id: GO:1903350 name: response to dopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945] -is_a: GO:0042493 ! response to drug is_a: GO:0071869 ! response to catecholamine created_by: mr creation_date: 2014-08-19T19:33:26Z @@ -524933,7 +522065,6 @@ id: GO:1903351 name: cellular response to dopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071870 ! cellular response to catecholamine stimulus is_a: GO:1903350 ! response to dopamine created_by: mr @@ -524944,7 +522075,6 @@ id: GO:1903352 name: L-ornithine transmembrane transport namespace: biological_process def: "The directed movement of L-ornithine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015822 ! ornithine transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport @@ -525919,7 +523049,6 @@ id: GO:1903400 name: L-arginine transmembrane transport namespace: biological_process def: "The directed movement of L-arginine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:1902023 ! L-arginine transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport is_a: GO:1903826 ! arginine transmembrane transport @@ -525931,7 +523060,6 @@ id: GO:1903401 name: L-lysine transmembrane transport namespace: biological_process def: "The directed movement of L-lysine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902022 ! L-lysine transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport @@ -526234,7 +523362,6 @@ id: GO:1903412 name: response to bile acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound @@ -526246,7 +523373,6 @@ id: GO:1903413 name: cellular response to bile acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -526844,8 +523970,8 @@ synonym: "androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] synonym: "androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] synonym: "androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "androstenedione biosynthetic process" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process -is_a: GO:0120178 ! steroid hormone biosynthetic process created_by: mr creation_date: 2014-09-19T20:18:19Z @@ -526964,7 +524090,6 @@ synonym: "regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie synonym: "regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010566 ! regulation of ketone biosynthetic process -is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process @@ -527007,7 +524132,7 @@ synonym: "negative regulation of androst-4-ene-3,17-dione formation" EXACT [GOC: synonym: "negative regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process -is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -527051,7 +524176,7 @@ synonym: "upregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGen synonym: "upregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0010893 ! positive regulation of steroid biosynthetic process -is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -527753,10 +524878,7 @@ id: GO:1903492 name: response to acetylsalicylate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aspirin (acetylsalicylate) stimulus. Aspirin is a non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity." [GO_REF:0000071, GOC:TermGenie, PMID:23392654] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0061476 ! response to anticoagulant -is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2014-09-25T10:58:23Z @@ -527768,8 +524890,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clopidogrel stimulus. Clopidogrel is a is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease." [GO_REF:0000071, GOC:TermGenie, PMID:23392654] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0061476 ! response to anticoagulant -is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:1901700 ! response to oxygen-containing compound created_by: hp creation_date: 2014-09-25T11:36:42Z @@ -527779,7 +524899,6 @@ id: GO:1903494 name: response to dehydroepiandrosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] -is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:0097305 ! response to alcohol @@ -527792,7 +524911,6 @@ id: GO:1903495 name: cellular response to dehydroepiandrosterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] -is_a: GO:0032870 ! cellular response to hormone stimulus is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097306 ! cellular response to alcohol @@ -529351,8 +526469,6 @@ id: GO:1903576 name: response to L-arginine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628] -is_a: GO:0007584 ! response to nutrient -is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: mr creation_date: 2014-10-29T22:18:39Z @@ -529362,8 +526478,6 @@ id: GO:1903577 name: cellular response to L-arginine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628] -is_a: GO:0031670 ! cellular response to nutrient -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1903576 ! response to L-arginine created_by: mr @@ -529789,7 +526903,6 @@ is_a: GO:0043304 ! regulation of mast cell degranulation is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0051239 ! regulation of multicellular organismal process -is_a: GO:0051588 ! regulation of neurotransmitter transport intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0002553 ! histamine secretion by mast cell relationship: regulates GO:0002553 ! histamine secretion by mast cell @@ -529810,7 +526923,6 @@ is_a: GO:0043305 ! negative regulation of mast cell degranulation is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0051241 ! negative regulation of multicellular organismal process -is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:1903593 ! regulation of histamine secretion by mast cell intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0002553 ! histamine secretion by mast cell @@ -529832,7 +526944,6 @@ is_a: GO:0043306 ! positive regulation of mast cell degranulation is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0051240 ! positive regulation of multicellular organismal process -is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903593 ! regulation of histamine secretion by mast cell intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0002553 ! histamine secretion by mast cell @@ -531040,7 +528151,6 @@ synonym: "negative regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of chlorophyll degradation" EXACT [GOC:TermGenie] is_a: GO:0010271 ! regulation of chlorophyll catabolic process -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1901405 ! negative regulation of tetrapyrrole catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0015996 ! chlorophyll catabolic process @@ -531073,7 +528183,6 @@ synonym: "upregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of chlorophyll degradation" EXACT [GOC:TermGenie] is_a: GO:0010271 ! regulation of chlorophyll catabolic process -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1901406 ! positive regulation of tetrapyrrole catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0015996 ! chlorophyll catabolic process @@ -532243,7 +529352,6 @@ name: spermine transmembrane transport namespace: biological_process def: "The process in which spermine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075] is_a: GO:0000296 ! spermine transport -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902047 ! polyamine transmembrane transport created_by: vw @@ -532315,28 +529423,6 @@ is_a: GO:1904823 ! purine nucleobase transmembrane transport created_by: vw creation_date: 2014-12-08T12:18:27Z -[Term] -id: GO:1903717 -name: response to ammonia -namespace: biological_process -def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonia stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] -is_a: GO:0009636 ! response to toxic substance -is_a: GO:0010035 ! response to inorganic substance -is_a: GO:1901698 ! response to nitrogen compound -created_by: ha -creation_date: 2014-12-08T14:55:44Z - -[Term] -id: GO:1903718 -name: cellular response to ammonia -namespace: biological_process -def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonia stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] -is_a: GO:0097237 ! cellular response to toxic substance -is_a: GO:1901699 ! cellular response to nitrogen compound -is_a: GO:1903717 ! response to ammonia -created_by: ha -creation_date: 2014-12-08T14:55:54Z - [Term] id: GO:1903719 name: regulation of I-kappaB phosphorylation @@ -532998,17 +530084,15 @@ creation_date: 2014-12-18T13:05:59Z [Term] id: GO:1903759 -name: signal transduction involved in regulation of aerobic respiration +name: obsolete signal transduction involved in regulation of aerobic respiration namespace: biological_process -def: "Any signal transduction that is involved in regulation of aerobic respiration." [GO_REF:0000060, GOC:TermGenie, PMID:19266076] +def: "OBSOLETE. Any signal transduction that is involved in regulation of aerobic respiration." [GO_REF:0000060, GOC:TermGenie, PMID:19266076] +comment: The reason for obsoletion is that this represents a GO-CAM model. synonym: "signaling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie] synonym: "signaling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie] synonym: "signalling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie] synonym: "signalling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie] -is_a: GO:0007165 ! signal transduction -intersection_of: GO:0007165 ! signal transduction -intersection_of: part_of GO:1903715 ! regulation of aerobic respiration -relationship: part_of GO:1903715 ! regulation of aerobic respiration +is_obsolete: true created_by: al creation_date: 2014-12-18T16:37:50Z @@ -533599,7 +530683,6 @@ id: GO:1903785 name: L-valine transmembrane transport namespace: biological_process def: "The directed movement of L-valine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20944394] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015829 ! valine transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport @@ -533618,7 +530701,6 @@ synonym: "regulation of glutathione synthesis" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process -is_a: GO:0051193 ! regulation of cofactor metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0006750 ! glutathione biosynthetic process relationship: regulates GO:0006750 ! glutathione biosynthetic process @@ -533657,7 +530739,6 @@ synonym: "negative regulation of glutathione synthesis" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process -is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:1903786 ! regulation of glutathione biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006750 ! glutathione biosynthetic process @@ -533697,7 +530778,6 @@ synonym: "upregulation of glutathione synthesis" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process -is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:1903786 ! regulation of glutathione biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006750 ! glutathione biosynthetic process @@ -533736,7 +530816,6 @@ id: GO:1903791 name: uracil transmembrane transport namespace: biological_process def: "The process in which uracil is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:8948441] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015857 ! uracil transport is_a: GO:1904082 ! pyrimidine nucleobase transmembrane transport created_by: vw @@ -533781,7 +530860,6 @@ id: GO:1903794 name: cortisol binding namespace: molecular_function def: "Interacting selectively and non-covalently with cortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:18483153] -is_a: GO:0008144 ! drug binding is_a: GO:0043178 ! alcohol binding is_a: GO:1990239 ! steroid hormone binding created_by: mr @@ -534053,7 +531131,6 @@ def: "The directed movement of L-glutamine from outside of a cell, across the pl synonym: "L-glutamine import" BROAD [] synonym: "L-glutamine import into cell" EXACT [] synonym: "L-glutamine uptake" EXACT [GOC:bf] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0006868 ! glutamine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport @@ -534069,8 +531146,6 @@ alt_id: GO:0036233 def: "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "glycine import" BROAD [] synonym: "glycine import into cell" EXACT [] -is_a: GO:0001504 ! neurotransmitter uptake -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015816 ! glycine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport @@ -534116,7 +531191,6 @@ def: "The directed movement of L-threonine from outside of a cell, across the pl synonym: "L-threonine import" BROAD [] synonym: "L-threonine import into cell" EXACT [] synonym: "L-threonine uptake" EXACT [GOC:bf] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015826 ! threonine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport @@ -534133,7 +531207,6 @@ def: "The directed movement of L-tyrosine from outside of a cell, across the pla synonym: "L-tyrosine import" BROAD [] synonym: "L-tyrosine import into cell" EXACT [] synonym: "L-tyrosine uptake" EXACT [GOC:bf] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015828 ! tyrosine transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:0098655 ! cation transmembrane transport @@ -534164,7 +531237,6 @@ alt_id: GO:0090469 def: "The directed movement of L-asparagine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] synonym: "asparagine import" BROAD [] synonym: "L-asparagine import into cell" EXACT [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0089718 ! amino acid import across plasma membrane is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport is_a: GO:1903713 ! asparagine transmembrane transport @@ -534649,7 +531721,6 @@ id: GO:1903840 name: response to arsenite(3-) namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] -is_a: GO:0001101 ! response to acid chemical is_a: GO:1903842 ! response to arsenite ion created_by: mr creation_date: 2015-01-22T19:49:25Z @@ -534659,7 +531730,6 @@ id: GO:1903841 name: cellular response to arsenite(3-) namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:1903840 ! response to arsenite(3-) is_a: GO:1903843 ! cellular response to arsenite ion created_by: mr @@ -535487,6 +532557,7 @@ name: 21-deoxycortisol binding namespace: molecular_function def: "Interacting selectively and non-covalently with 21-deoxycortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] is_a: GO:0005496 ! steroid binding +is_a: GO:0043178 ! alcohol binding created_by: mr creation_date: 2015-02-06T16:02:54Z @@ -535515,7 +532586,6 @@ name: 17alpha-hydroxyprogesterone binding namespace: molecular_function def: "Interacting selectively and non-covalently with 17alpha-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] is_a: GO:0005496 ! steroid binding -is_a: GO:0042562 ! hormone binding is_a: GO:0043178 ! alcohol binding created_by: mr creation_date: 2015-02-06T16:03:22Z @@ -536806,7 +533876,6 @@ name: estradiol binding namespace: molecular_function def: "Interacting selectively and non-covalently with estradiol." [GO_REF:0000067, GOC:TermGenie, PMID:9048584] is_a: GO:0005496 ! steroid binding -is_a: GO:0099130 ! estrogen binding created_by: sl creation_date: 2015-02-11T00:11:34Z @@ -536815,10 +533884,7 @@ id: GO:1903925 name: response to bisphenol A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036] -is_a: GO:0009410 ! response to xenobiotic stimulus -is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-02-11T00:16:46Z @@ -536828,10 +533894,7 @@ id: GO:1903926 name: cellular response to bisphenol A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036] -is_a: GO:0032870 ! cellular response to hormone stimulus -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1903925 ! response to bisphenol A created_by: sl @@ -536842,8 +533905,6 @@ id: GO:1903927 name: response to cyanide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848] -is_a: GO:0001101 ! response to acid chemical -is_a: GO:0009636 ! response to toxic substance is_a: GO:0010033 ! response to organic substance created_by: sl creation_date: 2015-02-11T19:04:19Z @@ -536853,8 +533914,7 @@ id: GO:1903928 name: cellular response to cyanide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848] -is_a: GO:0071229 ! cellular response to acid chemical -is_a: GO:0097237 ! cellular response to toxic substance +is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1903927 ! response to cyanide created_by: sl creation_date: 2015-02-11T19:04:28Z @@ -536969,12 +534029,8 @@ id: GO:1903935 name: response to sodium arsenite namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524] -is_a: GO:0009635 ! response to herbicide is_a: GO:0010035 ! response to inorganic substance -is_a: GO:0017085 ! response to insecticide -is_a: GO:0046677 ! response to antibiotic is_a: GO:0046685 ! response to arsenic-containing substance -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1902074 ! response to salt created_by: sl creation_date: 2015-02-12T20:54:33Z @@ -536984,10 +534040,7 @@ id: GO:1903936 name: cellular response to sodium arsenite namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071243 ! cellular response to arsenic-containing substance -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1902075 ! cellular response to salt is_a: GO:1903935 ! response to sodium arsenite created_by: sl @@ -536998,7 +534051,6 @@ id: GO:1903937 name: response to acrylamide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499] -is_a: GO:0009636 ! response to toxic substance is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl @@ -537010,7 +534062,6 @@ name: cellular response to acrylamide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499] is_a: GO:0071417 ! cellular response to organonitrogen compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1903937 ! response to acrylamide created_by: sl @@ -537390,7 +534441,6 @@ id: GO:1903956 name: response to latrunculin B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin B stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18951025] -is_a: GO:0009636 ! response to toxic substance is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol @@ -537404,7 +534454,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin B stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18951025] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1903956 ! response to latrunculin B created_by: al @@ -537541,8 +534590,6 @@ name: response to micafungin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959] is_a: GO:0033993 ! response to lipid -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901652 ! response to peptide created_by: al creation_date: 2015-02-27T09:57:38Z @@ -537552,8 +534599,6 @@ id: GO:1903968 name: cellular response to micafungin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901653 ! cellular response to peptide is_a: GO:1903967 ! response to micafungin @@ -537818,10 +534863,8 @@ namespace: molecular_function def: "Interacting selectively and non-covalently with enterobactin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:21951132] synonym: "enterochelin binding" EXACT [] synonym: "siderophore binding" BROAD [] +is_a: GO:0005527 ! macrolide binding is_a: GO:0043168 ! anion binding -is_a: GO:0048037 ! cofactor binding -is_a: GO:0097159 ! organic cyclic compound binding -is_a: GO:1901363 ! heterocyclic compound binding created_by: mr creation_date: 2015-03-02T17:21:54Z @@ -538394,7 +535437,7 @@ id: GO:1904010 name: response to Aroclor 1254 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130] -is_a: GO:0009636 ! response to toxic substance +is_a: GO:0042221 ! response to chemical created_by: sl creation_date: 2015-03-06T18:35:00Z @@ -538403,7 +535446,7 @@ id: GO:1904011 name: cellular response to Aroclor 1254 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130] -is_a: GO:0097237 ! cellular response to toxic substance +is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1904010 ! response to Aroclor 1254 created_by: sl creation_date: 2015-03-06T18:35:06Z @@ -539152,8 +536195,6 @@ alt_id: GO:0070283 def: "Interacting selectively and non-covalently with S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361] synonym: "radical SAM enzyme activity" NARROW [] xref: Reactome:R-HSA-947535 "Cyclisation of GTP to precursor Z" -is_a: GO:0008144 ! drug binding -is_a: GO:0050662 ! coenzyme binding is_a: GO:1901681 ! sulfur compound binding created_by: hal creation_date: 2015-03-17T10:32:16Z @@ -539546,7 +536587,6 @@ id: GO:1904067 name: ascr#2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with ascr#2." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:22665789] -is_a: GO:0005550 ! pheromone binding is_a: GO:0097367 ! carbohydrate derivative binding created_by: kmv creation_date: 2015-03-20T01:39:04Z @@ -540346,8 +537386,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0061478 ! response to platelet aggregation inhibitor -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: mr creation_date: 2015-03-30T22:36:26Z @@ -540357,7 +537395,6 @@ id: GO:1904102 name: cellular response to acadesine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -541952,33 +538989,35 @@ creation_date: 2015-05-07T17:02:40Z [Term] id: GO:1904198 -name: negative regulation of regulation of vascular smooth muscle cell membrane depolarization +name: negative regulation of regulation of vascular associated smooth muscle cell membrane depolarization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] synonym: "down regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "down-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "downregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "inhibition of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [] is_a: GO:1904180 ! negative regulation of membrane depolarization intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization -relationship: negatively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization +intersection_of: negatively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization +relationship: negatively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization created_by: sl creation_date: 2015-05-07T17:16:44Z [Term] id: GO:1904199 -name: positive regulation of regulation of vascular smooth muscle cell membrane depolarization +name: positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] synonym: "activation of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie] +synonym: "positive regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [] synonym: "up regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "up-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] synonym: "upregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] is_a: GO:1904181 ! positive regulation of membrane depolarization intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization -relationship: positively_regulates GO:1990736 ! regulation of vascular smooth muscle cell membrane depolarization +intersection_of: positively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization +relationship: positively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization created_by: sl creation_date: 2015-05-07T17:16:50Z @@ -542087,66 +539126,6 @@ relationship: positively_regulates GO:0014734 ! skeletal muscle hypertrophy created_by: sl creation_date: 2015-05-08T17:38:25Z -[Term] -id: GO:1904207 -name: regulation of chemokine (C-C motif) ligand 2 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297] -synonym: "regulation of CCL2 secretion" EXACT [GOC:TermGenie] -is_a: GO:0090196 ! regulation of chemokine secretion -is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion -relationship: regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion -created_by: sl -creation_date: 2015-05-11T16:47:07Z - -[Term] -id: GO:1904208 -name: negative regulation of chemokine (C-C motif) ligand 2 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297] -synonym: "down regulation of CCL2 secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of CCL2 secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of CCL2 secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] -synonym: "inhibition of CCL2 secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie] -synonym: "negative regulation of CCL2 secretion" EXACT [GOC:TermGenie] -is_a: GO:0090198 ! negative regulation of chemokine secretion -is_a: GO:1904207 ! regulation of chemokine (C-C motif) ligand 2 secretion -is_a: GO:2000342 ! negative regulation of chemokine (C-X-C motif) ligand 2 production -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion -relationship: negatively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion -created_by: sl -creation_date: 2015-05-11T16:47:13Z - -[Term] -id: GO:1904209 -name: positive regulation of chemokine (C-C motif) ligand 2 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24260297] -synonym: "activation of CCL2 secretion" NARROW [GOC:TermGenie] -synonym: "activation of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie] -synonym: "positive regulation of CCL2 secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of CCL2 secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of CCL2 secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of CCL2 secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of chemokine (C-C motif) ligand 2 secretion" EXACT [GOC:TermGenie] -is_a: GO:0090197 ! positive regulation of chemokine secretion -is_a: GO:1904207 ! regulation of chemokine (C-C motif) ligand 2 secretion -is_a: GO:2000343 ! positive regulation of chemokine (C-X-C motif) ligand 2 production -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion -relationship: positively_regulates GO:0035926 ! chemokine (C-C motif) ligand 2 secretion -created_by: sl -creation_date: 2015-05-11T16:47:19Z - [Term] id: GO:1904210 name: VCP-NPL4-UFD1 AAA ATPase complex assembly @@ -545084,7 +542063,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0036276 ! response to antidepressant created_by: sl creation_date: 2015-06-10T17:00:31Z @@ -545093,7 +542071,6 @@ id: GO:1904308 name: cellular response to desipramine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1904307 ! response to desipramine @@ -545107,8 +542084,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460] synonym: "response to 3'-deoxyadenosine" EXACT [GOC:sl] is_a: GO:0014074 ! response to purine-containing compound -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-06-10T17:10:29Z @@ -545119,7 +542094,6 @@ name: cellular response to cordycepin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460] synonym: "cellular response to 3'-deoxyadenosine" EXACT [GOC:sl] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -545191,9 +542165,8 @@ synonym: "response to PAF" EXACT [] synonym: "response to platelet-activating factor" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0033993 ! response to lipid -is_a: GO:0042493 ! response to drug +is_a: GO:0045472 ! response to ether is_a: GO:0046683 ! response to organophosphorus -is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-06-10T18:10:17Z @@ -545204,10 +542177,9 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918] synonym: "cellular response to PAF" EXACT [] synonym: "cellular response to platelet-activating factor" EXACT [] -is_a: GO:0035690 ! cellular response to drug +is_a: GO:0071362 ! cellular response to ether is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071417 ! cellular response to organonitrogen compound -is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904316 ! response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine created_by: sl creation_date: 2015-06-10T18:10:23Z @@ -545289,8 +542261,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0061478 ! response to platelet aggregation inhibitor is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone created_by: sl @@ -545301,8 +542271,6 @@ id: GO:1904322 name: cellular response to forskolin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0097306 ! cellular response to alcohol @@ -546040,7 +543008,6 @@ name: regulation of calcitonin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] is_a: GO:0090276 ! regulation of peptide hormone secretion -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0036161 ! calcitonin secretion relationship: regulates GO:0036161 ! calcitonin secretion @@ -546058,7 +543025,6 @@ synonym: "downregulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "inhibition of calcitonin secretion" NARROW [GOC:TermGenie] is_a: GO:0090278 ! negative regulation of peptide hormone secretion is_a: GO:1904362 ! regulation of calcitonin secretion -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0036161 ! calcitonin secretion relationship: negatively_regulates GO:0036161 ! calcitonin secretion @@ -546076,7 +543042,6 @@ synonym: "up-regulation of calcitonin secretion" EXACT [GOC:TermGenie] synonym: "upregulation of calcitonin secretion" EXACT [GOC:TermGenie] is_a: GO:0090277 ! positive regulation of peptide hormone secretion is_a: GO:1904362 ! regulation of calcitonin secretion -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036161 ! calcitonin secretion relationship: positively_regulates GO:0036161 ! calcitonin secretion @@ -546220,7 +543185,6 @@ name: response to kainic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789] is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: sl creation_date: 2015-06-18T22:42:52Z @@ -546230,7 +543194,6 @@ id: GO:1904374 name: cellular response to kainic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1904373 ! response to kainic acid @@ -546696,7 +543659,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-06-23T21:10:45Z @@ -546706,7 +543668,6 @@ id: GO:1904403 name: cellular response to nocodazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901655 ! cellular response to ketone @@ -546720,7 +543681,6 @@ name: response to formaldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109] is_a: GO:0010033 ! response to organic substance -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2015-06-23T21:14:04Z @@ -546730,7 +543690,6 @@ id: GO:1904405 name: cellular response to formaldehyde namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0110096 ! cellular response to aldehyde is_a: GO:1904404 ! response to formaldehyde created_by: sl @@ -546750,7 +543709,6 @@ synonym: "downregulation of nitric oxide metabolism" EXACT [GOC:TermGenie] synonym: "inhibition of nitric oxide metabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of nitric oxide metabolism" NARROW [GOC:TermGenie] synonym: "negative regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] -is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process @@ -546773,7 +543731,6 @@ synonym: "up-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] synonym: "upregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of nitric oxide metabolism" EXACT [GOC:TermGenie] -is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process intersection_of: GO:0008150 ! biological_process @@ -546787,9 +543744,7 @@ id: GO:1904408 name: melatonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with melatonin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923] -is_a: GO:0008144 ! drug binding is_a: GO:0033218 ! amide binding -is_a: GO:0042562 ! hormone binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding created_by: mr @@ -548110,27 +545065,28 @@ creation_date: 2015-07-09T19:50:14Z [Term] id: GO:1904470 -name: regulation of endothelin secretion +name: regulation of endothelin production namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] +def: "Any process that modulates the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] synonym: "regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "regulation of endothelin secretion" NARROW [] synonym: "regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] -is_a: GO:0050707 ! regulation of cytokine secretion +is_a: GO:0001817 ! regulation of cytokine production intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:1990775 ! endothelin secretion -relationship: regulates GO:1990775 ! endothelin secretion +intersection_of: regulates GO:1990775 ! endothelin production +relationship: regulates GO:1990775 ! endothelin production created_by: sl creation_date: 2015-07-09T19:57:57Z [Term] id: GO:1904471 -name: negative regulation of endothelin secretion +name: negative regulation of endothelin production namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] synonym: "down regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "down regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "down regulation of EDN3 secretion" NARROW [GOC:TermGenie] @@ -548162,22 +545118,23 @@ synonym: "inhibition of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of endothelin secretion" NARROW [] synonym: "negative regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "negative regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:1904470 ! regulation of endothelin secretion +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:1904470 ! regulation of endothelin production intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:1990775 ! endothelin secretion -relationship: negatively_regulates GO:1990775 ! endothelin secretion +intersection_of: negatively_regulates GO:1990775 ! endothelin production +relationship: negatively_regulates GO:1990775 ! endothelin production created_by: sl creation_date: 2015-07-09T19:58:03Z [Term] id: GO:1904472 -name: positive regulation of endothelin secretion +name: positive regulation of endothelin production namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of endothelin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] +def: "Any process that activates or increases the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] synonym: "activation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "activation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "activation of EDN3 secretion" NARROW [GOC:TermGenie] @@ -548188,6 +545145,7 @@ synonym: "activation of endothelin-3 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of EDN1 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of EDN2 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of endothelin secretion" NARROW [] synonym: "positive regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "positive regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] @@ -548212,11 +545170,11 @@ synonym: "upregulation of endothelin secretion" EXACT [GOC:TermGenie] synonym: "upregulation of endothelin-1 secretion" NARROW [GOC:TermGenie] synonym: "upregulation of endothelin-2 secretion" NARROW [GOC:TermGenie] synonym: "upregulation of endothelin-3 secretion" NARROW [GOC:TermGenie] -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:1904470 ! regulation of endothelin secretion +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:1904470 ! regulation of endothelin production intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:1990775 ! endothelin secretion -relationship: positively_regulates GO:1990775 ! endothelin secretion +intersection_of: positively_regulates GO:1990775 ! endothelin production +relationship: positively_regulates GO:1990775 ! endothelin production created_by: sl creation_date: 2015-07-09T19:58:10Z @@ -548225,9 +545183,7 @@ id: GO:1904473 name: response to L-dopa namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243] -is_a: GO:0009636 ! response to toxic substance is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid is_a: GO:1904386 ! response to L-phenylalanine derivative created_by: sl @@ -548238,10 +545194,8 @@ id: GO:1904474 name: cellular response to L-dopa namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1904387 ! cellular response to L-phenylalanine derivative is_a: GO:1904473 ! response to L-dopa created_by: sl @@ -548358,7 +545312,6 @@ id: GO:1904481 name: response to tetrahydrofolate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901700 ! response to oxygen-containing compound @@ -548370,7 +545323,6 @@ id: GO:1904482 name: cellular response to tetrahydrofolate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160] -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -548401,10 +545353,8 @@ id: GO:1904486 name: response to 17alpha-ethynylestradiol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421] -is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid -is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound created_by: mr creation_date: 2015-07-15T22:31:36Z @@ -548414,8 +545364,6 @@ id: GO:1904487 name: cellular response to 17alpha-ethynylestradiol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421] -is_a: GO:0032870 ! cellular response to hormone stimulus -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071396 ! cellular response to lipid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -549776,7 +546724,6 @@ id: GO:1904555 name: L-proline transmembrane transport namespace: biological_process def: "The directed movement of L-proline across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0035524 ! proline transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport created_by: pr @@ -549787,7 +546734,6 @@ id: GO:1904556 name: L-tryptophan transmembrane transport namespace: biological_process def: "The directed movement of L-tryptophan across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015827 ! tryptophan transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport @@ -549810,10 +546756,7 @@ id: GO:1904558 name: response to dextromethorphan namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] -is_a: GO:0009410 ! response to xenobiotic stimulus -is_a: GO:0009636 ! response to toxic substance is_a: GO:0014072 ! response to isoquinoline alkaloid -is_a: GO:0042493 ! response to drug is_a: GO:0045472 ! response to ether created_by: mr creation_date: 2015-08-14T16:09:17Z @@ -549823,11 +546766,8 @@ id: GO:1904559 name: cellular response to dextromethorphan namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071317 ! cellular response to isoquinoline alkaloid is_a: GO:0071362 ! cellular response to ether -is_a: GO:0071466 ! cellular response to xenobiotic stimulus -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1904558 ! response to dextromethorphan created_by: mr creation_date: 2015-08-14T16:09:24Z @@ -549839,7 +546779,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug is_a: GO:0097305 ! response to alcohol created_by: mr creation_date: 2015-08-14T16:09:31Z @@ -549849,7 +546788,6 @@ id: GO:1904561 name: cellular response to diphenidol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097306 ! cellular response to alcohol @@ -550073,7 +547011,7 @@ id: GO:1904576 name: response to tunicamycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] -is_a: GO:0046677 ! response to antibiotic +is_a: GO:0042221 ! response to chemical created_by: sl creation_date: 2015-08-19T18:01:52Z @@ -550082,7 +547020,7 @@ id: GO:1904577 name: cellular response to tunicamycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] -is_a: GO:0071236 ! cellular response to antibiotic +is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1904576 ! response to tunicamycin created_by: sl creation_date: 2015-08-19T18:01:58Z @@ -550665,7 +547603,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] synonym: "response to PCB 126" EXACT [] is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0042493 ! response to drug created_by: sl creation_date: 2015-08-27T18:52:49Z @@ -550675,7 +547612,6 @@ name: cellular response to 3,3',4,4',5-pentachlorobiphenyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] synonym: "cellular response to PCB 126" EXACT [] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1904610 ! response to 3,3',4,4',5-pentachlorobiphenyl created_by: sl @@ -550688,7 +547624,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] synonym: "response to dioxin" EXACT [] synonym: "response to TCDD" EXACT [] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014070 ! response to organic cyclic compound created_by: sl creation_date: 2015-08-27T19:01:52Z @@ -550701,7 +547636,6 @@ def: "Any process that results in a change in state or activity of a cell (in te synonym: "cellular response to dioxin" EXACT [] synonym: "cellular response to TCDD" EXACT [] is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1904612 ! response to 2,3,7,8-tetrachlorodibenzodioxine created_by: sl creation_date: 2015-08-27T19:01:58Z @@ -550712,7 +547646,6 @@ name: response to biphenyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0060992 ! response to fungicide created_by: sl creation_date: 2015-08-27T19:08:43Z @@ -550721,9 +547654,7 @@ id: GO:1904615 name: cellular response to biphenyl namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1904614 ! response to biphenyl created_by: sl creation_date: 2015-08-27T19:08:49Z @@ -550792,7 +547723,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812] synonym: "response to DMSO" EXACT [] is_a: GO:0010033 ! response to organic substance -is_a: GO:0042493 ! response to drug created_by: sl creation_date: 2015-08-27T19:13:49Z @@ -550802,7 +547732,7 @@ name: cellular response to dimethyl sulfoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812] synonym: "cellular response to DMSO" EXACT [] -is_a: GO:0035690 ! cellular response to drug +is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1904619 ! response to dimethyl sulfoxide created_by: sl creation_date: 2015-08-27T19:14:07Z @@ -550872,7 +547802,6 @@ def: "Any process that modulates the frequency, rate or extent of glycine secret is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061537 ! glycine secretion, neurotransmission relationship: regulates GO:0061537 ! glycine secretion, neurotransmission @@ -550892,7 +547821,6 @@ is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:0060093 ! negative regulation of synaptic transmission, glycinergic is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission relationship: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission @@ -550912,7 +547840,6 @@ is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061537 ! glycine secretion, neurotransmission relationship: positively_regulates GO:0061537 ! glycine secretion, neurotransmission @@ -550930,7 +547857,6 @@ synonym: "response to tetradecanoylphorbol acetate" EXACT [] synonym: "response to TPA" EXACT [] is_a: GO:0033993 ! response to lipid is_a: GO:0097305 ! response to alcohol -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-08-28T13:44:03Z @@ -550944,7 +547870,6 @@ synonym: "cellular response to phorbol 12-tetradecanoate 13-acetate" EXACT [] synonym: "cellular response to response to PMA" EXACT [] synonym: "cellular response to tetradecanoylphorbol acetate" EXACT [] synonym: "cellular response to TPA" EXACT [] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071396 ! cellular response to lipid is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901655 ! cellular response to ketone @@ -551121,7 +548046,6 @@ id: GO:1904638 name: response to resveratrol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] -is_a: GO:0009636 ! response to toxic substance is_a: GO:0035634 ! response to stilbenoid is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl @@ -551133,7 +548057,6 @@ name: cellular response to resveratrol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904638 ! response to resveratrol created_by: sl @@ -551180,8 +548103,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-08-31T20:38:11Z @@ -551191,8 +548112,6 @@ id: GO:1904644 name: cellular response to curcumin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071362 ! cellular response to ether is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901655 ! cellular response to ketone @@ -551229,8 +548148,6 @@ name: response to rotenone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940] is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0017085 ! response to insecticide -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901654 ! response to ketone created_by: sl creation_date: 2015-08-31T20:55:32Z @@ -551240,9 +548157,7 @@ id: GO:1904648 name: cellular response to rotenone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1901655 ! cellular response to ketone is_a: GO:1904647 ! response to rotenone created_by: sl @@ -551705,7 +548620,6 @@ namespace: biological_process def: "The directed movement of ATP out of a cell or organelle." [GO_REF:0000074, GOC:TermGenie, PMID:24286344] synonym: "ATP efflux" RELATED [] is_a: GO:0015867 ! ATP transport -is_a: GO:0046618 ! drug export created_by: tb creation_date: 2015-09-09T16:33:06Z @@ -552155,37 +549069,39 @@ creation_date: 2015-09-29T09:15:28Z [Term] id: GO:1904694 -name: negative regulation of vascular smooth muscle contraction +name: negative regulation of vascular associated smooth muscle contraction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624] synonym: "down regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle contraction" NARROW [GOC:TermGenie] -is_a: GO:0003056 ! regulation of vascular smooth muscle contraction +synonym: "negative regulation of vascular smooth muscle contraction" EXACT [] +is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction is_a: GO:0045906 ! negative regulation of vasoconstriction is_a: GO:0045986 ! negative regulation of smooth muscle contraction intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0014829 ! vascular smooth muscle contraction -relationship: negatively_regulates GO:0014829 ! vascular smooth muscle contraction +intersection_of: negatively_regulates GO:0014829 ! vascular associated smooth muscle contraction +relationship: negatively_regulates GO:0014829 ! vascular associated smooth muscle contraction created_by: rph creation_date: 2015-09-29T13:39:08Z [Term] id: GO:1904695 -name: positive regulation of vascular smooth muscle contraction +name: positive regulation of vascular associated smooth muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624] synonym: "activation of vascular smooth muscle contraction" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle contraction" EXACT [] synonym: "up regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] -is_a: GO:0003056 ! regulation of vascular smooth muscle contraction +is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction is_a: GO:0045907 ! positive regulation of vasoconstriction is_a: GO:0045987 ! positive regulation of smooth muscle contraction intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0014829 ! vascular smooth muscle contraction -relationship: positively_regulates GO:0014829 ! vascular smooth muscle contraction +intersection_of: positively_regulates GO:0014829 ! vascular associated smooth muscle contraction +relationship: positively_regulates GO:0014829 ! vascular associated smooth muscle contraction created_by: rph creation_date: 2015-09-29T13:39:14Z @@ -552370,20 +549286,21 @@ creation_date: 2015-10-01T15:12:02Z [Term] id: GO:1904705 -name: regulation of vascular smooth muscle cell proliferation +name: regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] +synonym: "regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048660 ! regulation of smooth muscle cell proliferation intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:1990874 ! vascular smooth muscle cell proliferation -relationship: regulates GO:1990874 ! vascular smooth muscle cell proliferation +intersection_of: regulates GO:1990874 ! vascular associated smooth muscle cell proliferation +relationship: regulates GO:1990874 ! vascular associated smooth muscle cell proliferation created_by: sl creation_date: 2015-10-01T16:05:20Z [Term] id: GO:1904706 -name: negative regulation of vascular smooth muscle cell proliferation +name: negative regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] @@ -552394,22 +549311,24 @@ synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GO synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation -is_a: GO:1904705 ! regulation of vascular smooth muscle cell proliferation +is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:1990874 ! vascular smooth muscle cell proliferation -relationship: negatively_regulates GO:1990874 ! vascular smooth muscle cell proliferation +intersection_of: negatively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation +relationship: negatively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation created_by: sl creation_date: 2015-10-01T16:05:26Z [Term] id: GO:1904707 -name: positive regulation of vascular smooth muscle cell proliferation +name: positive regulation of vascular associated smooth muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell proliferation" EXACT [] synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie] @@ -552418,10 +549337,10 @@ synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie] is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation -is_a: GO:1904705 ! regulation of vascular smooth muscle cell proliferation +is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:1990874 ! vascular smooth muscle cell proliferation -relationship: positively_regulates GO:1990874 ! vascular smooth muscle cell proliferation +intersection_of: positively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation +relationship: positively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation created_by: sl creation_date: 2015-10-01T16:05:32Z @@ -554425,7 +551344,6 @@ synonym: "negative regulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "negative regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0006744 ! ubiquinone biosynthetic process @@ -554514,7 +551432,6 @@ synonym: "upregulation of ubiquinone formation" EXACT [GOC:TermGenie] synonym: "upregulation of ubiquinone synthesis" EXACT [GOC:TermGenie] is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0006744 ! ubiquinone biosynthetic process @@ -555120,7 +552037,6 @@ id: GO:1904804 name: response to latrunculin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15537703] -is_a: GO:0009636 ! response to toxic substance is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol @@ -555134,7 +552050,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a latrunculin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15537703] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1904804 ! response to latrunculin A created_by: mah @@ -555458,7 +552373,6 @@ synonym: "regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process -is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0070814 ! hydrogen sulfide biosynthetic process relationship: regulates GO:0070814 ! hydrogen sulfide biosynthetic process @@ -555506,7 +552420,6 @@ synonym: "negative regulation of hydrogen sulphide biosynthesis" EXACT [GOC:Term synonym: "negative regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process -is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process @@ -555555,7 +552468,6 @@ synonym: "upregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process -is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process @@ -555568,7 +552480,7 @@ id: GO:1904829 name: regulation of aortic smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] -is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035887 ! aortic smooth muscle cell differentiation relationship: regulates GO:0035887 ! aortic smooth muscle cell differentiation @@ -555585,7 +552497,7 @@ synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [G synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation -is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation +is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation relationship: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation @@ -555602,7 +552514,7 @@ synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation -is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation +is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation relationship: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation @@ -555835,7 +552747,6 @@ synonym: "response to nitroglycerine" EXACT [] synonym: "response to nitroglycerol" EXACT [] synonym: "response to trinitroglycerin" EXACT [] synonym: "response to trinitroglycerol" EXACT [] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0010033 ! response to organic substance is_a: GO:0042493 ! response to drug is_a: GO:1901698 ! response to nitrogen compound @@ -555853,7 +552764,6 @@ synonym: "cellular response to nitroglycerol" EXACT [] synonym: "cellular response to trinitroglycerin" EXACT [] synonym: "cellular response to trinitroglycerol" EXACT [] is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1904842 ! response to nitroglycerin @@ -555865,8 +552775,6 @@ id: GO:1904844 name: response to L-glutamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570] -is_a: GO:0007584 ! response to nutrient -is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: sl creation_date: 2015-12-07T19:39:17Z @@ -555876,8 +552784,6 @@ id: GO:1904845 name: cellular response to L-glutamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570] -is_a: GO:0031670 ! cellular response to nutrient -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1904844 ! response to L-glutamine created_by: sl @@ -556576,10 +553482,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591] synonym: "response to dihydridosulfur" EXACT [] synonym: "response to sulfane" EXACT [] -is_a: GO:0001101 ! response to acid chemical -is_a: GO:0009636 ! response to toxic substance is_a: GO:0010035 ! response to inorganic substance -is_a: GO:0042493 ! response to drug created_by: sl creation_date: 2016-01-04T23:56:27Z @@ -556590,9 +553493,7 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591] synonym: "cellular response to dihydridosulfur" EXACT [] synonym: "cellular response to sulfane" EXACT [] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071229 ! cellular response to acid chemical -is_a: GO:0097237 ! cellular response to toxic substance +is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1904880 ! response to hydrogen sulfide created_by: sl creation_date: 2016-01-04T23:56:35Z @@ -558708,17 +555609,24 @@ creation_date: 2016-02-12T17:57:03Z id: GO:1904967 name: regulation of monopolar spindle attachment to meiosis I kinetochore namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, PMID:23770679] +alt_id: GO:0090699 +def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:21920317, PMID:23770679] +synonym: "correction of merotelic kinetochore attachment, meiosis I" RELATED [] synonym: "regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] synonym: "regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [] synonym: "regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] synonym: "regulation of monopolar attachment" EXACT [GOC:TermGenie] synonym: "regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] +synonym: "repair of merotelic kinetochore attachment defect, meiosis I" RELATED [] is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore is_a: GO:0060629 ! regulation of homologous chromosome segregation +is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect +is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore +relationship: part_of GO:0043060 ! meiotic metaphase I plate congression relationship: regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore +property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/18815 xsd:anyURI created_by: mah creation_date: 2016-02-15T15:19:12Z @@ -558899,7 +555807,6 @@ id: GO:1904975 name: response to bleomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781] -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901652 ! response to peptide created_by: mah creation_date: 2016-02-18T15:21:23Z @@ -558909,7 +555816,6 @@ id: GO:1904976 name: cellular response to bleomycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781] -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:1901653 ! cellular response to peptide is_a: GO:1904975 ! response to bleomycin created_by: mah @@ -559019,7 +555925,6 @@ name: glycine import into mitochondrion namespace: biological_process def: "The process in which glycine is transported from the cytosol, into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380] synonym: "transmembrane glycine transport from cytosol to mitochondrion" EXACT [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015816 ! glycine transport is_a: GO:0043090 ! amino acid import is_a: GO:0098655 ! cation transmembrane transport @@ -559538,7 +556443,6 @@ synonym: "regulation of lysine import" BROAD [] synonym: "regulation of lysine uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0097639 ! L-lysine import across plasma membrane relationship: regulates GO:0097639 ! L-lysine import across plasma membrane @@ -559562,7 +556466,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097639 ! L-lysine import across plasma membrane relationship: negatively_regulates GO:0097639 ! L-lysine import across plasma membrane @@ -559583,7 +556486,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097639 ! L-lysine import across plasma membrane relationship: positively_regulates GO:0097639 ! L-lysine import across plasma membrane @@ -559609,7 +556511,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] synonym: "regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:0090357 ! regulation of tryptophan metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan @@ -559633,7 +556534,6 @@ synonym: "inhibition of de novo NAD biosynthetic process from tryptophan" RELATE synonym: "negative regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan @@ -559656,7 +556556,6 @@ synonym: "up-regulation of de novo NAD biosynthetic process from tryptophan" REL synonym: "upregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] synonym: "upregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process -is_a: GO:0051197 ! positive regulation of coenzyme metabolic process is_a: GO:0090358 ! positive regulation of tryptophan metabolic process is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan intersection_of: GO:0008150 ! biological_process @@ -560783,22 +557682,22 @@ creation_date: 2016-03-21T11:00:23Z [Term] id: GO:1905063 -name: regulation of vascular smooth muscle cell differentiation +name: regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] -synonym: "regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051150 ! regulation of smooth muscle cell differentiation is_a: GO:1901342 ! regulation of vasculature development intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0035886 ! vascular smooth muscle cell differentiation -relationship: regulates GO:0035886 ! vascular smooth muscle cell differentiation +intersection_of: regulates GO:0035886 ! vascular associated smooth muscle cell differentiation +relationship: regulates GO:0035886 ! vascular associated smooth muscle cell differentiation created_by: rph creation_date: 2016-03-21T11:14:53Z [Term] id: GO:1905064 -name: negative regulation of vascular smooth muscle cell differentiation +name: negative regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] @@ -560813,26 +557712,26 @@ synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie] -synonym: "negative regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation is_a: GO:1901343 ! negative regulation of vasculature development -is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0035886 ! vascular smooth muscle cell differentiation -relationship: negatively_regulates GO:0035886 ! vascular smooth muscle cell differentiation +intersection_of: negatively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation +relationship: negatively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation created_by: rph creation_date: 2016-03-21T11:15:03Z [Term] id: GO:1905065 -name: positive regulation of vascular smooth muscle cell differentiation +name: positive regulation of vascular associated smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie] -synonym: "positive regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] @@ -560845,10 +557744,10 @@ synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GO synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie] is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation is_a: GO:1904018 ! positive regulation of vasculature development -is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0035886 ! vascular smooth muscle cell differentiation -relationship: positively_regulates GO:0035886 ! vascular smooth muscle cell differentiation +intersection_of: positively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation +relationship: positively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation created_by: rph creation_date: 2016-03-21T11:15:13Z @@ -561039,113 +557938,6 @@ relationship: positively_regulates GO:1905071 ! tight junction disassembly created_by: rl creation_date: 2016-03-23T19:33:10Z -[Term] -id: GO:1905076 -name: regulation of interleukin-17 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511] -comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511 (inferred from direct assay). -synonym: "regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] -synonym: "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] -synonym: "regulation of IL-17 secretion" EXACT [GOC:TermGenie] -synonym: "regulation of IL-17A secretion" EXACT [GOC:TermGenie] -synonym: "regulation of IL17A secretion" EXACT [GOC:TermGenie] -is_a: GO:0032660 ! regulation of interleukin-17 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0072615 ! interleukin-17 secretion -relationship: regulates GO:0072615 ! interleukin-17 secretion -created_by: bhm -creation_date: 2016-03-24T15:44:21Z - -[Term] -id: GO:1905077 -name: negative regulation of interleukin-17 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511] -comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511 (inferred from direct assay). -synonym: "down regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of IL-17 secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of IL-17A secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of IL17A secretion" EXACT [GOC:TermGenie] -synonym: "down regulation of interleukin-17 secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of IL-17 secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of IL-17A secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of IL17A secretion" EXACT [GOC:TermGenie] -synonym: "down-regulation of interleukin-17 secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of CTLA-8 secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of IL-17 secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of IL-17A secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of IL17A secretion" EXACT [GOC:TermGenie] -synonym: "downregulation of interleukin-17 secretion" EXACT [GOC:TermGenie] -synonym: "inhibition of CTLA-8 secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of Cytotoxic T-lymphocyte-associated antigen 8 secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of IL-17 secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of IL-17A secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of IL17A secretion" NARROW [GOC:TermGenie] -synonym: "inhibition of interleukin-17 secretion" NARROW [GOC:TermGenie] -synonym: "negative regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] -synonym: "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] -synonym: "negative regulation of IL-17 secretion" EXACT [GOC:TermGenie] -synonym: "negative regulation of IL-17A secretion" EXACT [GOC:TermGenie] -synonym: "negative regulation of IL17A secretion" EXACT [GOC:TermGenie] -is_a: GO:0032700 ! negative regulation of interleukin-17 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:1905076 ! regulation of interleukin-17 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0072615 ! interleukin-17 secretion -relationship: negatively_regulates GO:0072615 ! interleukin-17 secretion -created_by: bhm -creation_date: 2016-03-24T15:44:31Z - -[Term] -id: GO:1905078 -name: positive regulation of interleukin-17 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-17 secretion." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:16482511] -comment: An example of this is IL23A in human (Q9NPF7) in PMID:16482511 (inferred from direct assay). -synonym: "activation of CTLA-8 secretion" NARROW [GOC:TermGenie] -synonym: "activation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" NARROW [GOC:TermGenie] -synonym: "activation of IL-17 secretion" NARROW [GOC:TermGenie] -synonym: "activation of IL-17A secretion" NARROW [GOC:TermGenie] -synonym: "activation of IL17A secretion" NARROW [GOC:TermGenie] -synonym: "activation of interleukin-17 secretion" NARROW [GOC:TermGenie] -synonym: "positive regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] -synonym: "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] -synonym: "positive regulation of IL-17 secretion" EXACT [GOC:TermGenie] -synonym: "positive regulation of IL-17A secretion" EXACT [GOC:TermGenie] -synonym: "positive regulation of IL17A secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of IL-17 secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of IL-17A secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of IL17A secretion" EXACT [GOC:TermGenie] -synonym: "up regulation of interleukin-17 secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of CTLA-8 secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of IL-17 secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of IL-17A secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of IL17A secretion" EXACT [GOC:TermGenie] -synonym: "up-regulation of interleukin-17 secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of CTLA-8 secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of IL-17 secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of IL-17A secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of IL17A secretion" EXACT [GOC:TermGenie] -synonym: "upregulation of interleukin-17 secretion" EXACT [GOC:TermGenie] -is_a: GO:0032740 ! positive regulation of interleukin-17 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:1905076 ! regulation of interleukin-17 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0072615 ! interleukin-17 secretion -relationship: positively_regulates GO:0072615 ! interleukin-17 secretion -created_by: bhm -creation_date: 2016-03-24T15:44:40Z - [Term] id: GO:1905079 name: regulation of cerebellar neuron development @@ -561384,9 +558176,7 @@ name: response to diosgenin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596] is_a: GO:0036314 ! response to sterol -is_a: GO:0046677 ! response to antibiotic is_a: GO:0097305 ! response to alcohol -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1905836 ! response to triterpenoid created_by: bc creation_date: 2016-03-31T11:04:28Z @@ -561396,9 +558186,7 @@ id: GO:1905093 name: cellular response to diosgenin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0036315 ! cellular response to sterol -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1905092 ! response to diosgenin is_a: GO:1905837 ! cellular response to triterpenoid @@ -561977,7 +558765,6 @@ subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097305 ! response to alcohol -is_a: GO:0097332 ! response to antipsychotic drug is_a: GO:1901654 ! response to ketone created_by: dw creation_date: 2016-04-08T12:36:39Z @@ -561989,7 +558776,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097306 ! cellular response to alcohol @@ -562383,7 +559169,6 @@ alt_id: GO:1901689 def: "The directed movement of biotin from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:12557275] synonym: "biotin import" RELATED [] synonym: "biotin import into cell" EXACT [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015878 ! biotin transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0098657 ! import into cell @@ -562549,8 +559334,7 @@ id: GO:1905144 name: response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] -is_a: GO:0009725 ! response to hormone -is_a: GO:0042493 ! response to drug +is_a: GO:0010033 ! response to organic substance is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: dos @@ -562561,8 +559345,6 @@ id: GO:1905145 name: cellular response to acetylcholine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] -is_a: GO:0032870 ! cellular response to hormone stimulus -is_a: GO:0035690 ! cellular response to drug is_a: GO:1901699 ! cellular response to nitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905144 ! response to acetylcholine @@ -563230,50 +560012,53 @@ creation_date: 2016-05-03T11:00:21Z [Term] id: GO:1905174 -name: regulation of vascular smooth muscle cell dedifferentiation +name: regulation of vascular associated smooth muscle cell dedifferentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] +synonym: "regulation of vascular smooth muscle cell dedifferentiation" EXACT [] is_a: GO:0050793 ! regulation of developmental process is_a: GO:1900239 ! regulation of phenotypic switching intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation -relationship: regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation +intersection_of: regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation +relationship: regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation created_by: rph creation_date: 2016-05-03T12:31:57Z [Term] id: GO:1905175 -name: negative regulation of vascular smooth muscle cell dedifferentiation +name: negative regulation of vascular associated smooth muscle cell dedifferentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "down regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "down-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "downregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "inhibition of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell dedifferentiation" EXACT [] is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:1900240 ! negative regulation of phenotypic switching -is_a: GO:1905174 ! regulation of vascular smooth muscle cell dedifferentiation +is_a: GO:1905174 ! regulation of vascular associated smooth muscle cell dedifferentiation intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation -relationship: negatively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation +intersection_of: negatively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation +relationship: negatively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation created_by: rph creation_date: 2016-05-03T12:32:05Z [Term] id: GO:1905176 -name: positive regulation of vascular smooth muscle cell dedifferentiation +name: positive regulation of vascular associated smooth muscle cell dedifferentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] synonym: "activation of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell dedifferentiation" EXACT [] synonym: "up regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "up-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] synonym: "upregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:1900241 ! positive regulation of phenotypic switching -is_a: GO:1905174 ! regulation of vascular smooth muscle cell dedifferentiation +is_a: GO:1905174 ! regulation of vascular associated smooth muscle cell dedifferentiation intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation -relationship: positively_regulates GO:1990936 ! vascular smooth muscle cell dedifferentiation +intersection_of: positively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation +relationship: positively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation created_by: rph creation_date: 2016-05-03T12:32:13Z @@ -563292,7 +560077,6 @@ name: regulation of cardiac muscle tissue regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] is_a: GO:0048638 ! regulation of developmental growth -is_a: GO:0061041 ! regulation of wound healing intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061026 ! cardiac muscle tissue regeneration relationship: regulates GO:0061026 ! cardiac muscle tissue regeneration @@ -563309,7 +560093,6 @@ synonym: "down-regulation of cardiac muscle tissue regeneration" EXACT [GOC:Term synonym: "downregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] synonym: "inhibition of cardiac muscle tissue regeneration" NARROW [GOC:TermGenie] is_a: GO:0048640 ! negative regulation of developmental growth -is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0061026 ! cardiac muscle tissue regeneration @@ -563327,7 +560110,6 @@ synonym: "up regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGe synonym: "up-regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] synonym: "upregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] is_a: GO:0048639 ! positive regulation of developmental growth -is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0061026 ! cardiac muscle tissue regeneration @@ -563735,7 +560517,6 @@ synonym: "upregulation of hydrogen peroxide-mediated cell death" RELATED [GOC:Te is_a: GO:1901033 ! positive regulation of response to reactive oxygen species is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death -is_a: GO:2001040 ! positive regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0036474 ! cell death in response to hydrogen peroxide relationship: positively_regulates GO:0036474 ! cell death in response to hydrogen peroxide @@ -563929,7 +560710,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505] synonym: "response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT [] is_a: GO:0033993 ! response to lipid -is_a: GO:0061476 ! response to anticoagulant created_by: sl creation_date: 2016-06-06T21:30:00Z @@ -563939,7 +560719,6 @@ name: cellular response to astaxanthin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505] synonym: "cellular response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT [] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071396 ! cellular response to lipid is_a: GO:1905217 ! response to astaxanthin created_by: sl @@ -564063,7 +560842,7 @@ id: GO:1905226 name: regulation of adhesion of symbiont to host epithelial cell namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068] -is_a: GO:0043903 ! regulation of interspecies interactions between organisms +is_a: GO:0043903 ! regulation of symbiotic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0044651 ! adhesion of symbiont to host epithelial cell relationship: regulates GO:0044651 ! adhesion of symbiont to host epithelial cell @@ -564141,8 +560920,6 @@ name: cellular response to L-glutamate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25962137] synonym: "cellular response to L-glutamate(1-)" RELATED [] -is_a: GO:0031670 ! cellular response to nutrient -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1902065 ! response to L-glutamate created_by: sl @@ -564153,9 +560930,7 @@ id: GO:1905233 name: response to codeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] -is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014072 ! response to isoquinoline alkaloid -is_a: GO:0042493 ! response to drug created_by: sl creation_date: 2016-06-07T21:26:45Z @@ -564164,9 +560939,7 @@ id: GO:1905234 name: cellular response to codeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071317 ! cellular response to isoquinoline alkaloid -is_a: GO:0071466 ! cellular response to xenobiotic stimulus is_a: GO:1905233 ! response to codeine created_by: sl creation_date: 2016-06-07T21:26:53Z @@ -564176,9 +560949,6 @@ id: GO:1905235 name: response to quercetin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] -is_a: GO:0009725 ! response to hormone -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1905395 ! response to flavonoid created_by: sl creation_date: 2016-06-07T21:29:40Z @@ -564188,9 +560958,6 @@ id: GO:1905236 name: cellular response to quercetin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] -is_a: GO:0032870 ! cellular response to hormone stimulus -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:1905235 ! response to quercetin is_a: GO:1905396 ! cellular response to flavonoid created_by: sl @@ -564202,8 +560969,6 @@ name: response to cyclosporin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] synonym: "response to cyclophilin" EXACT [] -is_a: GO:0042493 ! response to drug -is_a: GO:0046677 ! response to antibiotic is_a: GO:1901652 ! response to peptide created_by: sl creation_date: 2016-06-07T21:32:06Z @@ -564214,8 +560979,6 @@ name: cellular response to cyclosporin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] synonym: "cellular response to cyclophilin" EXACT [] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:1901653 ! cellular response to peptide is_a: GO:1905237 ! response to cyclosporin A created_by: sl @@ -564313,7 +561076,6 @@ synonym: "response to Liothyronine" EXACT [] synonym: "response to Liothyroninum" EXACT [] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043200 ! response to amino acid -is_a: GO:0097066 ! response to thyroid hormone created_by: sl creation_date: 2016-06-08T17:42:04Z @@ -564327,7 +561089,6 @@ synonym: "cellular response to Liothyronine" EXACT [] synonym: "cellular response to Liothyroninum" EXACT [] is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:0071407 ! cellular response to organic cyclic compound -is_a: GO:0097067 ! cellular response to thyroid hormone stimulus is_a: GO:1905242 ! response to 3,3',5-triiodo-L-thyronine created_by: sl creation_date: 2016-06-08T17:42:12Z @@ -564527,6 +561288,7 @@ name: regulation of RNA binding transcription factor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] synonym: "regulation of transcription factor activity" BROAD [GOC:TermGenie] +is_a: GO:0050789 ! regulation of biological process is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0001070 ! RNA-binding transcription regulator activity @@ -564544,6 +561306,7 @@ synonym: "down-regulation of RNA binding transcription factor activity" EXACT [G synonym: "downregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] synonym: "inhibition of RNA binding transcription factor activity" NARROW [GOC:TermGenie] is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0048519 ! negative regulation of biological process is_a: GO:1905255 ! regulation of RNA binding transcription factor activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0001070 ! RNA-binding transcription regulator activity @@ -564561,6 +561324,7 @@ synonym: "up regulation of RNA binding transcription factor activity" EXACT [GOC synonym: "up-regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] synonym: "upregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] is_a: GO:0044093 ! positive regulation of molecular function +is_a: GO:0048518 ! positive regulation of biological process is_a: GO:1905255 ! regulation of RNA binding transcription factor activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0001070 ! RNA-binding transcription regulator activity @@ -564696,7 +561460,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S] synonym: "blasticidin S metabolism" EXACT [GOC:TermGenie] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process -is_a: GO:0016999 ! antibiotic metabolic process created_by: pr creation_date: 2016-06-14T12:47:05Z @@ -564708,7 +561471,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of blastici synonym: "blasticidin S breakdown" EXACT [GOC:TermGenie] synonym: "blasticidin S catabolism" EXACT [GOC:TermGenie] synonym: "blasticidin S degradation" EXACT [GOC:TermGenie] -is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0046135 ! pyrimidine nucleoside catabolic process is_a: GO:1905264 ! blasticidin S metabolic process created_by: pr @@ -564723,7 +561485,6 @@ synonym: "blasticidin S anabolism" EXACT [GOC:TermGenie] synonym: "blasticidin S biosynthesis" EXACT [GOC:TermGenie] synonym: "blasticidin S formation" EXACT [GOC:TermGenie] synonym: "blasticidin S synthesis" EXACT [GOC:TermGenie] -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process is_a: GO:1905264 ! blasticidin S metabolic process created_by: pr @@ -564821,7 +561582,8 @@ synonym: "regulation of hydrogen ion translocating F-type ATPase activity" EXACT synonym: "regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] is_a: GO:0010155 ! regulation of proton transport -is_a: GO:0051338 ! regulation of transferase activity +is_a: GO:0051340 ! regulation of ligase activity +is_a: GO:2001169 ! regulation of ATP biosynthetic process is_a: GO:2001257 ! regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism @@ -564858,8 +561620,9 @@ synonym: "negative regulation of H+-transporting ATP synthase activity" EXACT [G synonym: "negative regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "negative regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] -is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:0051352 ! negative regulation of ligase activity is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism +is_a: GO:2001170 ! negative regulation of ATP biosynthetic process is_a: GO:2001258 ! negative regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism @@ -564896,8 +561659,9 @@ synonym: "upregulation of hydrogen ion translocating F-type ATPase activity" EXA synonym: "upregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] synonym: "upregulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] synonym: "upregulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] -is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:0051351 ! positive regulation of ligase activity is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism +is_a: GO:2001171 ! positive regulation of ATP biosynthetic process is_a: GO:2001259 ! positive regulation of cation channel activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism @@ -565639,8 +562403,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097327 ! response to antineoplastic agent created_by: al creation_date: 2016-07-06T11:55:22Z @@ -565649,8 +562411,6 @@ id: GO:1905308 name: cellular response to miconazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1905307 ! response to miconazole @@ -567380,7 +564140,6 @@ def: "Any process that modulates the frequency, rate or extent of creatine trans is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:1903959 ! regulation of anion transmembrane transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0005308 ! creatine transmembrane transporter activity relationship: regulates GO:0005308 ! creatine transmembrane transporter activity @@ -567400,7 +564159,6 @@ is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:0032891 ! negative regulation of organic acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0005308 ! creatine transmembrane transporter activity relationship: negatively_regulates GO:0005308 ! creatine transmembrane transporter activity @@ -567420,7 +564178,6 @@ is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity is_a: GO:0032892 ! positive regulation of organic acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0005308 ! creatine transmembrane transporter activity relationship: positively_regulates GO:0005308 ! creatine transmembrane transporter activity @@ -567607,35 +564364,20 @@ relationship: positively_regulates GO:0097723 ! amoeboid sperm motility created_by: pr creation_date: 2016-09-01T11:29:03Z -[Term] -id: GO:1905419 -name: sperm flagellum movement involved in flagellated sperm motility -namespace: biological_process -alt_id: GO:0097724 -def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031] -synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc] -synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie] -is_a: GO:0022414 ! reproductive process -is_a: GO:0060294 ! cilium movement involved in cell motility -intersection_of: GO:0003341 ! cilium movement -intersection_of: part_of GO:0030317 ! flagellated sperm motility -relationship: part_of GO:0030317 ! flagellated sperm motility -created_by: krc -creation_date: 2016-09-01T17:52:39Z - [Term] id: GO:1905420 -name: vascular smooth muscle cell differentiation involved in phenotypic switching +name: vascular associated smooth muscle cell differentiation involved in phenotypic switching namespace: biological_process def: "Any vascular smooth muscle cell differentiation that is involved in phenotypic switching." [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [] synonym: "VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] -is_a: GO:0035886 ! vascular smooth muscle cell differentiation +is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation is_a: GO:0090679 ! cell differentiation involved in phenotypic switching -intersection_of: GO:0035886 ! vascular smooth muscle cell differentiation +intersection_of: GO:0035886 ! vascular associated smooth muscle cell differentiation intersection_of: part_of GO:0090677 ! reversible differentiation created_by: rph creation_date: 2016-09-05T12:43:46Z @@ -568380,8 +565122,6 @@ synonym: "response to aminoacetic acid" EXACT [] synonym: "response to aminoethanoic acid" EXACT [] synonym: "response to Gly" EXACT [] synonym: "response to glycin" EXACT [] -is_a: GO:0007584 ! response to nutrient -is_a: GO:0042493 ! response to drug is_a: GO:0043200 ! response to amino acid created_by: sl creation_date: 2016-09-08T22:09:15Z @@ -568395,8 +565135,6 @@ synonym: "cellular response to aminoacetic acid" EXACT [] synonym: "cellular response to aminoethanoic acid" EXACT [] synonym: "cellular response to Gly" EXACT [] synonym: "cellular response to glycin" EXACT [] -is_a: GO:0031670 ! cellular response to nutrient -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071230 ! cellular response to amino acid stimulus is_a: GO:1905429 ! response to glycine created_by: sl @@ -568408,7 +565146,6 @@ name: microcystin transport namespace: biological_process def: "The directed movement of a microcystin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:TermGenie, PMID:26055554] is_a: GO:0015833 ! peptide transport -is_a: GO:1901998 ! toxin transport created_by: cvs creation_date: 2016-09-13T23:15:51Z @@ -568551,7 +565288,6 @@ id: GO:1905439 name: response to chondroitin 6'-sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: cvs @@ -568562,7 +565298,6 @@ id: GO:1905440 name: cellular response to chondroitin 6'-sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905439 ! response to chondroitin 6'-sulfate @@ -568574,7 +565309,6 @@ id: GO:1905441 name: response to chondroitin 4'-sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] -is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound created_by: cvs @@ -568585,7 +565319,6 @@ id: GO:1905442 name: cellular response to chondroitin 4'-sulfate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] -is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1905441 ! response to chondroitin 4'-sulfate @@ -569838,12 +566571,9 @@ creation_date: 2016-09-27T10:50:04Z id: GO:1905502 name: acetyl-CoA binding namespace: molecular_function -def: "Interacting selectively and non-covalently with acetyl-CoA." [GO_REF:0000067, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:24927529] -is_a: GO:0032559 ! adenyl ribonucleotide binding -is_a: GO:0033218 ! amide binding -is_a: GO:0043168 ! anion binding -is_a: GO:0050662 ! coenzyme binding -is_a: GO:1901681 ! sulfur compound binding +def: "Interacting selectively and non-covalently with acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component." [GO_REF:0000067, GOC:bc, GOC:krc, GOC:PARL, GOC:TermGenie, PMID:24927529] +synonym: "acetyl-coenzyme A binding" EXACT [] +is_a: GO:0120227 ! acyl-CoA binding created_by: bc creation_date: 2016-09-27T16:33:44Z @@ -570444,7 +567174,6 @@ name: regulation of uracil import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126] is_a: GO:0034762 ! regulation of transmembrane transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0098721 ! uracil import across plasma membrane relationship: regulates GO:0098721 ! uracil import across plasma membrane @@ -570458,7 +567187,6 @@ namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126] is_a: GO:0034763 ! negative regulation of transmembrane transport is_a: GO:1905529 ! regulation of uracil import across plasma membrane -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0098721 ! uracil import across plasma membrane relationship: negatively_regulates GO:0098721 ! uracil import across plasma membrane @@ -570472,7 +567200,6 @@ namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126] is_a: GO:0034764 ! positive regulation of transmembrane transport is_a: GO:1905529 ! regulation of uracil import across plasma membrane -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0098721 ! uracil import across plasma membrane relationship: positively_regulates GO:0098721 ! uracil import across plasma membrane @@ -570682,7 +567409,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0097638 ! L-arginine import across plasma membrane relationship: negatively_regulates GO:0097638 ! L-arginine import across plasma membrane @@ -570711,7 +567437,6 @@ namespace: biological_process alt_id: GO:1903813 def: "The directed movement of L-methionine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:17556368] synonym: "L-methionine import into cell" EXACT [] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport is_a: GO:1903692 ! methionine import across plasma membrane created_by: mah @@ -571879,7 +568604,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0097638 ! L-arginine import across plasma membrane relationship: positively_regulates GO:0097638 ! L-arginine import across plasma membrane @@ -572647,7 +569371,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:1904062 ! regulation of cation transmembrane transport -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1905544 ! L-methionine import across plasma membrane relationship: regulates GO:1905544 ! L-methionine import across plasma membrane @@ -572663,7 +569386,6 @@ is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:1904063 ! negative regulation of cation transmembrane transport is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1905544 ! L-methionine import across plasma membrane relationship: negatively_regulates GO:1905544 ! L-methionine import across plasma membrane @@ -572679,7 +569401,6 @@ is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:1904064 ! positive regulation of cation transmembrane transport is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1905544 ! L-methionine import across plasma membrane relationship: positively_regulates GO:1905544 ! L-methionine import across plasma membrane @@ -572695,7 +569416,6 @@ synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie] synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie] synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie] -is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0008150 ! biological_process @@ -573180,7 +569900,7 @@ id: GO:1905654 name: regulation of artery smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] -is_a: GO:0003056 ! regulation of vascular smooth muscle contraction +is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0014824 ! artery smooth muscle contraction relationship: regulates GO:0014824 ! artery smooth muscle contraction @@ -573196,7 +569916,7 @@ synonym: "down regulation of artery smooth muscle contraction" EXACT [GOC:TermGe synonym: "down-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "downregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "inhibition of artery smooth muscle contraction" NARROW [GOC:TermGenie] -is_a: GO:1904694 ! negative regulation of vascular smooth muscle contraction +is_a: GO:1904694 ! negative regulation of vascular associated smooth muscle contraction is_a: GO:1905654 ! regulation of artery smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0014824 ! artery smooth muscle contraction @@ -573213,7 +569933,7 @@ synonym: "activation of artery smooth muscle contraction" NARROW [GOC:TermGenie] synonym: "up regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "up-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] synonym: "upregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] -is_a: GO:1904695 ! positive regulation of vascular smooth muscle contraction +is_a: GO:1904695 ! positive regulation of vascular associated smooth muscle contraction is_a: GO:1905654 ! regulation of artery smooth muscle contraction intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0014824 ! artery smooth muscle contraction @@ -574169,7 +570889,6 @@ id: GO:1905705 name: cellular response to paclitaxel namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18472094] -is_a: GO:0035690 ! cellular response to drug is_a: GO:0071396 ! cellular response to lipid is_a: GO:1901555 ! response to paclitaxel created_by: sl @@ -574507,7 +571226,6 @@ name: regulation of L-proline import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] is_a: GO:1902834 ! regulation of proline import across plasma membrane -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:1904271 ! L-proline import across plasma membrane relationship: regulates GO:1904271 ! L-proline import across plasma membrane @@ -574521,7 +571239,6 @@ namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] is_a: GO:1902835 ! negative regulation of proline import across plasma membrane is_a: GO:1905735 ! regulation of L-proline import across plasma membrane -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:1904271 ! L-proline import across plasma membrane relationship: negatively_regulates GO:1904271 ! L-proline import across plasma membrane @@ -574535,7 +571252,6 @@ namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] is_a: GO:1902836 ! positive regulation of proline import across plasma membrane is_a: GO:1905735 ! regulation of L-proline import across plasma membrane -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:1904271 ! L-proline import across plasma membrane relationship: positively_regulates GO:1904271 ! L-proline import across plasma membrane @@ -575539,8 +572255,6 @@ namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288] synonym: "response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT [] is_a: GO:0014074 ! response to purine-containing compound -is_a: GO:0046677 ! response to antibiotic -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: sl creation_date: 2017-01-10T21:13:18Z @@ -575551,8 +572265,6 @@ name: cellular response to puromycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288] synonym: "cellular response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT [] -is_a: GO:0035690 ! cellular response to drug -is_a: GO:0071236 ! cellular response to antibiotic is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound @@ -576531,7 +573243,6 @@ id: GO:1905841 name: response to oxidopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876] -is_a: GO:0009636 ! response to toxic substance is_a: GO:0071869 ! response to catecholamine created_by: pr creation_date: 2017-01-19T09:49:03Z @@ -576542,7 +573253,6 @@ name: cellular response to oxidopamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876] is_a: GO:0071870 ! cellular response to catecholamine stimulus -is_a: GO:0097237 ! cellular response to toxic substance is_a: GO:1905841 ! response to oxidopamine created_by: pr creation_date: 2017-01-19T09:49:12Z @@ -578146,7 +574856,7 @@ synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] -is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0060408 ! regulation of acetylcholine metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008292 ! acetylcholine biosynthetic process @@ -578183,7 +574893,7 @@ synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] -is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0060410 ! negative regulation of acetylcholine metabolic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation @@ -578221,7 +574931,7 @@ synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie] synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] -is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process intersection_of: GO:0065007 ! biological regulation @@ -578335,25 +575045,25 @@ creation_date: 2017-02-08T21:39:14Z [Term] id: GO:1905930 -name: regulation of vascular smooth muscle cell differentiation involved in phenotypic switching +name: regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] -synonym: "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] -is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching -relationship: regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching +intersection_of: regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching +relationship: regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching created_by: rph creation_date: 2017-02-09T09:20:59Z [Term] id: GO:1905931 -name: negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching +name: negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] @@ -578383,20 +575093,21 @@ synonym: "inhibition of VSMC differentiation involved in phenotypic switching" N synonym: "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [] synonym: "negative regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "negative regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] -is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation +is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation is_a: GO:1905916 ! negative regulation of cell differentiation involved in phenotypic switching -is_a: GO:1905930 ! regulation of vascular smooth muscle cell differentiation involved in phenotypic switching +is_a: GO:1905930 ! regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching -relationship: negatively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching +intersection_of: negatively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching +relationship: negatively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching created_by: rph creation_date: 2017-02-09T09:21:08Z [Term] id: GO:1905932 -name: positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching +name: positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] synonym: "activation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] @@ -578406,8 +575117,8 @@ synonym: "activation of vascular smooth muscle cell differentiation involved in synonym: "activation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "activation of VSMC differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] synonym: "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] -synonym: "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "positive regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "positive regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] @@ -578428,12 +575139,12 @@ synonym: "upregulation of vascular smooth muscle cell differentiation involved i synonym: "upregulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] synonym: "upregulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] synonym: "upregulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] -is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation +is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation is_a: GO:1905917 ! positive regulation of cell differentiation involved in phenotypic switching -is_a: GO:1905930 ! regulation of vascular smooth muscle cell differentiation involved in phenotypic switching +is_a: GO:1905930 ! regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching -relationship: positively_regulates GO:1905420 ! vascular smooth muscle cell differentiation involved in phenotypic switching +intersection_of: positively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching +relationship: positively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching created_by: rph creation_date: 2017-02-09T09:21:17Z @@ -578970,8 +575681,8 @@ def: "Catalysis of the reaction: IDP + H2O = IMP + phosphate." [PMID:20385596, P synonym: "IDPase activity" EXACT [] synonym: "inosine diphosphatase activity" EXACT [] synonym: "inosine-diphosphatase activity" EXACT [] -xref: EC:3.1.3 xref: Reactome:R-HSA-2509816 "NUDT16 hydrolyses IDP to IMP" +xref: RHEA:35207 is_a: GO:0017110 ! nucleoside-diphosphatase activity is_a: GO:0098519 ! nucleotide phosphatase activity, acting on free nucleotides created_by: jl @@ -579522,7 +576233,6 @@ comment: Note that this term is in the subset of terms that should not be used f subset: gocheck_do_not_manually_annotate is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound -is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:1901700 ! response to oxygen-containing compound created_by: pr creation_date: 2013-02-22T10:09:44Z @@ -579534,6 +576244,7 @@ namespace: molecular_function def: "Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2." [MetaCyc:RXN-8990, PMID:16766535, PMID:23204519] synonym: "aromatic aldehyde synthase" BROAD [] xref: EC:4.1.1.109 +xref: RHEA:55532 is_a: GO:0016831 ! carboxy-lyase activity created_by: tb creation_date: 2013-02-25T20:22:35Z @@ -579868,6 +576579,7 @@ name: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltran namespace: molecular_function def: "Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methanol-specific corrinoid protein]." [GOC:hjd, PMID:10077852] xref: EC:2.1.1.246 +xref: RHEA:45208 is_a: GO:0008168 ! methyltransferase activity created_by: hjd creation_date: 2013-05-06T15:07:20Z @@ -582866,7 +579578,7 @@ creation_date: 2014-05-28T18:43:21Z id: GO:1990385 name: meiotic spindle midzone namespace: cellular_component -def: "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv\,PMID\:12707312] +def: "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv, PMID:12707312] is_a: GO:0051233 ! spindle midzone relationship: part_of GO:0072687 ! meiotic spindle created_by: kmv @@ -583026,6 +579738,7 @@ def: "The regrowth of lost or destroyed epithelium." [GOC:sl, PMID:19845688] synonym: "regeneration of epithelium" EXACT [] is_a: GO:0042246 ! tissue regeneration is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0042060 ! wound healing created_by: sl creation_date: 2014-06-12T17:14:42Z @@ -583190,7 +579903,7 @@ creation_date: 2014-07-03T21:26:24Z id: GO:1990414 name: replication-born double-strand break repair via sister chromatid exchange namespace: biological_process -def: "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [PMID:12820977, PMID:16888651\,GOC\:rb] +def: "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651] synonym: "replication-born DSB repair by SCE" EXACT [] is_a: GO:0000724 ! double-strand break repair via homologous recombination created_by: rb @@ -584613,7 +581326,6 @@ id: GO:1990544 name: mitochondrial ATP transmembrane transport namespace: biological_process def: "The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:18485069] -is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015867 ! ATP transport is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:0098656 ! anion transmembrane transport @@ -585205,19 +581917,6 @@ is_a: GO:0032991 ! protein-containing complex created_by: bf creation_date: 2015-01-05T15:14:35Z -[Term] -id: GO:1990598 -name: repair of mitotic mono-orientation defect -namespace: biological_process -def: "The mitotic cell cycle process where mono-orientation defects are corrected in order to ensure sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. Mono-orientation defects occur when both sister kinetochores are attached to MTs from one spindle pole in mitosis and meiosis II." [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536] -synonym: "correction of mono-orientation defects" EXACT [] -synonym: "correction of syntelic kinetochore attachment, mitotic" EXACT [GOC:vw] -synonym: "repair of mitotic mono-orientation defects" EXACT [] -is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling -is_a: GO:0140273 ! repair of mitotic kinetochore microtubule attachment defect -created_by: jl -creation_date: 2015-01-05T16:54:39Z - [Term] id: GO:1990599 name: 3' overhang single-stranded DNA endodeoxyribonuclease activity @@ -585315,6 +582014,7 @@ namespace: biological_process alt_id: GO:0070632 alt_id: GO:0071789 def: "A process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location." [PMID:24963130] +synonym: "establishment and maintenance of spindle pole body localization" EXACT [] synonym: "establishment of spindle pole body localisation" NARROW [GOC:mah] synonym: "establishment of spindle pole body localization" NARROW [] synonym: "mitotic spindle pole body localization to nuclear envelope" NARROW [] @@ -586759,9 +583459,10 @@ creation_date: 2015-04-29T14:40:20Z [Term] id: GO:1990736 -name: regulation of vascular smooth muscle cell membrane depolarization +name: regulation of vascular associated smooth muscle cell membrane depolarization namespace: biological_process def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell." [PMID:20826763] +synonym: "regulation of vascular smooth muscle cell membrane depolarization" EXACT [] is_a: GO:0051899 ! membrane depolarization created_by: sl creation_date: 2015-04-29T22:33:19Z @@ -586786,6 +583487,7 @@ name: pseudouridine 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate." [EC:3.1.3.96, PMID:20722631] xref: EC:3.1.3.96 +xref: RHEA:10944 is_a: GO:0016791 ! phosphatase activity created_by: vw creation_date: 2015-05-02T11:05:50Z @@ -587149,16 +583851,17 @@ creation_date: 2015-06-15T22:59:26Z [Term] id: GO:1990775 -name: endothelin secretion +name: endothelin production namespace: biological_process -def: "The regulated release of endothelin from a cell. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120] -synonym: "EDN1 secretion" NARROW [] -synonym: "EDN2 secretion" NARROW [] -synonym: "EDN3 secretion" NARROW [] +def: "The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120] +synonym: "EDN1 production" NARROW [] +synonym: "EDN2 production" NARROW [] +synonym: "EDN3 production" NARROW [] +synonym: "endothelin secretion" NARROW [] synonym: "endothelin-1 secretion" NARROW [] -synonym: "endothelin-2 secretion" NARROW [] -synonym: "endothelin-3 secretion" NARROW [] -is_a: GO:0050663 ! cytokine secretion +synonym: "endothelin-2 production" NARROW [] +synonym: "endothelin-3 production" NARROW [] +is_a: GO:0001816 ! cytokine production created_by: sl creation_date: 2015-06-15T23:13:18Z @@ -587631,7 +584334,6 @@ name: L-arginine transmembrane export from vacuole namespace: biological_process def: "The directed movement of L-arginine out of the vacuole, across the vacuolar membrane." [PMID:26083598] is_a: GO:0032974 ! amino acid transmembrane export from vacuole -is_a: GO:0046618 ! drug export is_a: GO:1903400 ! L-arginine transmembrane transport created_by: vw creation_date: 2015-08-06T15:06:33Z @@ -588223,9 +584925,10 @@ creation_date: 2015-09-29T10:06:25Z [Term] id: GO:1990874 -name: vascular smooth muscle cell proliferation +name: vascular associated smooth muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467] +synonym: "vascular smooth muscle cell proliferation" EXACT [] synonym: "VSMC proliferation" EXACT [] is_a: GO:0048659 ! smooth muscle cell proliferation created_by: sl @@ -588436,7 +585139,7 @@ creation_date: 2015-11-04T20:25:21Z id: GO:1990895 name: regulation of protein localization to cell cortex of cell tip namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip." [PMID:26150232\,GOC\:vw] +def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip." [GOC:vw, PMID:26150232] is_a: GO:1903066 ! regulation of protein localization to cell tip is_a: GO:1904776 ! regulation of protein localization to cell cortex intersection_of: GO:0008150 ! biological_process @@ -588704,7 +585407,10 @@ namespace: molecular_function def: "The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome." [PMID:16096059] synonym: "nuclear membrane proteasome adaptor" RELATED [] synonym: "nuclear membrane proteasome anchor" EXACT [] +synonym: "nuclear membrane proteasome tether" EXACT [] +synonym: "nuclear membrane proteasome tether activity" EXACT [] synonym: "nuclear membrane-proteasome anchor activity" EXACT [] +synonym: "nuclear membrane-proteasome tether activity" EXACT [] synonym: "tethering factor for nuclear proteasome" RELATED [] is_a: GO:0043495 ! protein-membrane adaptor activity property_value: term_tracker_item https://github.com/geneontology/go-ontology/issues/19119 xsd:anyURI @@ -588862,9 +585568,10 @@ creation_date: 2016-03-21T21:57:20Z [Term] id: GO:1990936 -name: vascular smooth muscle cell dedifferentiation +name: vascular associated smooth muscle cell dedifferentiation namespace: biological_process def: "The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19088079] +synonym: "vascular smooth muscle cell dedifferentiation" EXACT [] is_a: GO:0090678 ! cell dedifferentiation involved in phenotypic switching created_by: tb creation_date: 2016-03-22T20:25:11Z @@ -589808,7 +586515,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway." [GOC:obol] synonym: "regulation of salicylic acid mediated signalling pathway" EXACT [GOC:obol] is_a: GO:0009966 ! regulation of signal transduction -is_a: GO:2001038 ! regulation of cellular response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0009863 ! salicylic acid mediated signaling pathway relationship: regulates GO:0009863 ! salicylic acid mediated signaling pathway @@ -590626,7 +587332,6 @@ is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0030656 ! regulation of vitamin metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0019853 ! L-ascorbic acid biosynthetic process relationship: regulates GO:0019853 ! L-ascorbic acid biosynthetic process @@ -590649,7 +587354,6 @@ synonym: "negative regulation of vitamin C biosynthetic process" EXACT [GOC:obol is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:2000082 ! regulation of L-ascorbic acid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0019853 ! L-ascorbic acid biosynthetic process @@ -592713,7 +589417,6 @@ name: regulation of testosterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf] is_a: GO:0010566 ! regulation of ketone biosynthetic process -is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0061370 ! testosterone biosynthetic process @@ -592727,7 +589430,7 @@ name: negative regulation of testosterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process -is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:2000224 ! regulation of testosterone biosynthetic process intersection_of: GO:0008150 ! biological_process @@ -594470,7 +591173,12 @@ creation_date: 2011-02-01T10:46:33Z id: GO:2000341 name: regulation of chemokine (C-X-C motif) ligand 2 production namespace: biological_process +alt_id: GO:0035926 +alt_id: GO:1904207 def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] +synonym: "chemokine (C-C motif) ligand 2 secretion" NARROW [] +synonym: "regulation of CCL2 secretion" NARROW [GOC:TermGenie] +synonym: "regulation of chemokine (C-C motif) ligand 2 secretion" NARROW [] synonym: "regulation of CXCL2 production" EXACT [GOC:obol] synonym: "regulation of MIP-2 production" EXACT [GOC:obol] synonym: "regulation of MIP2 production" EXACT [GOC:obol] @@ -594486,7 +591194,11 @@ creation_date: 2011-02-01T11:57:14Z id: GO:2000342 name: negative regulation of chemokine (C-X-C motif) ligand 2 production namespace: biological_process +alt_id: GO:1904208 def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] +synonym: "inhibition of CCL2 secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of chemokine (C-C motif) ligand 2 secretion" NARROW [] synonym: "negative regulation of CXCL2 production" EXACT [GOC:obol] synonym: "negative regulation of MIP-2 production" EXACT [GOC:obol] synonym: "negative regulation of MIP2 production" EXACT [GOC:obol] @@ -594503,7 +591215,10 @@ creation_date: 2011-02-01T11:57:17Z id: GO:2000343 name: positive regulation of chemokine (C-X-C motif) ligand 2 production namespace: biological_process +alt_id: GO:1904209 def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] +synonym: "positive regulation of CCL2 secretion" EXACT [GOC:TermGenie] +synonym: "positive regulation of chemokine (C-C motif) ligand 2 secretion" NARROW [] synonym: "positive regulation of CXCL2 production" EXACT [GOC:obol] synonym: "positive regulation of MIP-2 production" EXACT [GOC:obol] synonym: "positive regulation of MIP2 production" EXACT [GOC:obol] @@ -596582,50 +593297,6 @@ relationship: positively_regulates GO:0004691 ! cAMP-dependent protein kinase ac created_by: yaf creation_date: 2011-03-10T11:14:17Z -[Term] -id: GO:2000482 -name: regulation of interleukin-8 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-8 secretion." [GOC:obol] -synonym: "regulation of IL-8 secretion" EXACT [GOC:obol] -is_a: GO:0032677 ! regulation of interleukin-8 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0072606 ! interleukin-8 secretion -relationship: regulates GO:0072606 ! interleukin-8 secretion -created_by: yaf -creation_date: 2011-03-10T02:37:11Z - -[Term] -id: GO:2000483 -name: negative regulation of interleukin-8 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion." [GOC:obol] -synonym: "negative regulation of IL-8 secretion" EXACT [GOC:obol] -is_a: GO:0032717 ! negative regulation of interleukin-8 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:2000482 ! regulation of interleukin-8 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0072606 ! interleukin-8 secretion -relationship: negatively_regulates GO:0072606 ! interleukin-8 secretion -created_by: yaf -creation_date: 2011-03-10T02:37:51Z - -[Term] -id: GO:2000484 -name: positive regulation of interleukin-8 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion." [GOC:obol] -synonym: "positive regulation of IL-8 secretion" EXACT [GOC:obol] -is_a: GO:0032757 ! positive regulation of interleukin-8 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:2000482 ! regulation of interleukin-8 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0072606 ! interleukin-8 secretion -relationship: positively_regulates GO:0072606 ! interleukin-8 secretion -created_by: yaf -creation_date: 2011-03-10T02:38:20Z - [Term] id: GO:2000485 name: regulation of glutamine transport @@ -597592,11 +594263,12 @@ creation_date: 2011-04-03T07:52:17Z [Term] id: GO:2000559 -name: regulation of CD24 biosynthetic process +name: regulation of CD24 production namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol] synonym: "regulation of CD24 anabolism" EXACT [GOC:obol] synonym: "regulation of CD24 biosynthesis" EXACT [GOC:obol] +synonym: "regulation of CD24 biosynthetic process" EXACT [] synonym: "regulation of CD24 formation" EXACT [GOC:obol] synonym: "regulation of CD24 synthesis" EXACT [GOC:obol] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process @@ -597608,15 +594280,16 @@ creation_date: 2011-04-03T08:56:56Z [Term] id: GO:2000560 -name: positive regulation of CD24 biosynthetic process +name: positive regulation of CD24 production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol] synonym: "positive regulation of CD24 anabolism" EXACT [GOC:obol] synonym: "positive regulation of CD24 biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of CD24 biosynthetic process" EXACT [] synonym: "positive regulation of CD24 formation" EXACT [GOC:obol] synonym: "positive regulation of CD24 synthesis" EXACT [GOC:obol] is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process -is_a: GO:2000559 ! regulation of CD24 biosynthetic process +is_a: GO:2000559 ! regulation of CD24 production intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035724 ! CD24 biosynthetic process relationship: positively_regulates GO:0035724 ! CD24 biosynthetic process @@ -598720,7 +595393,6 @@ def: "Any process that activates or increases the frequency, rate or extent of g synonym: "positive regulation of gene silencing by microRNA" RELATED [GOC:pr] synonym: "positive regulation of microRNA-mediated gene silencing" EXACT [GOC:obol] synonym: "positive regulation of miRNA-mediated gene silencing" EXACT [GOC:obol] -is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing is_a: GO:0060964 ! regulation of gene silencing by miRNA intersection_of: GO:0008150 ! biological_process @@ -599089,94 +595761,6 @@ relationship: positively_regulates GO:0070498 ! interleukin-1-mediated signaling created_by: dph creation_date: 2011-05-03T07:13:40Z -[Term] -id: GO:2000662 -name: regulation of interleukin-5 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-5 secretion." [GOC:obol] -synonym: "regulation of IL-5 secretion" EXACT [GOC:obol] -is_a: GO:0032674 ! regulation of interleukin-5 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0072603 ! interleukin-5 secretion -relationship: regulates GO:0072603 ! interleukin-5 secretion -created_by: yaf -creation_date: 2011-05-06T02:59:02Z - -[Term] -id: GO:2000663 -name: negative regulation of interleukin-5 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-5 secretion." [GOC:obol] -synonym: "negative regulation of IL-5 secretion" EXACT [GOC:obol] -is_a: GO:0032714 ! negative regulation of interleukin-5 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:2000662 ! regulation of interleukin-5 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0072603 ! interleukin-5 secretion -relationship: negatively_regulates GO:0072603 ! interleukin-5 secretion -created_by: yaf -creation_date: 2011-05-06T02:59:05Z - -[Term] -id: GO:2000664 -name: positive regulation of interleukin-5 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-5 secretion." [GOC:obol] -synonym: "positive regulation of IL-5 secretion" EXACT [GOC:obol] -is_a: GO:0032754 ! positive regulation of interleukin-5 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:2000662 ! regulation of interleukin-5 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0072603 ! interleukin-5 secretion -relationship: positively_regulates GO:0072603 ! interleukin-5 secretion -created_by: yaf -creation_date: 2011-05-06T02:59:07Z - -[Term] -id: GO:2000665 -name: regulation of interleukin-13 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-13 secretion." [GOC:obol] -synonym: "regulation of IL-13 secretion" EXACT [GOC:obol] -is_a: GO:0032656 ! regulation of interleukin-13 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0072611 ! interleukin-13 secretion -relationship: regulates GO:0072611 ! interleukin-13 secretion -created_by: yaf -creation_date: 2011-05-06T03:24:19Z - -[Term] -id: GO:2000666 -name: negative regulation of interleukin-13 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-13 secretion." [GOC:obol] -synonym: "negative regulation of IL-13 secretion" EXACT [GOC:obol] -is_a: GO:0032696 ! negative regulation of interleukin-13 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:2000665 ! regulation of interleukin-13 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0072611 ! interleukin-13 secretion -relationship: negatively_regulates GO:0072611 ! interleukin-13 secretion -created_by: yaf -creation_date: 2011-05-06T03:24:22Z - -[Term] -id: GO:2000667 -name: positive regulation of interleukin-13 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-13 secretion." [GOC:obol] -synonym: "positive regulation of IL-13 secretion" EXACT [GOC:obol] -is_a: GO:0032736 ! positive regulation of interleukin-13 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:2000665 ! regulation of interleukin-13 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0072611 ! interleukin-13 secretion -relationship: positively_regulates GO:0072611 ! interleukin-13 secretion -created_by: yaf -creation_date: 2011-05-06T03:24:25Z - [Term] id: GO:2000668 name: regulation of dendritic cell apoptotic process @@ -600027,7 +596611,7 @@ name: regulation of cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF] synonym: "regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol] -is_a: GO:1905063 ! regulation of vascular smooth muscle cell differentiation +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation is_a: GO:1905207 ! regulation of cardiocyte differentiation intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation @@ -600041,7 +596625,7 @@ name: negative regulation of cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF] synonym: "negative regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol] -is_a: GO:1905064 ! negative regulation of vascular smooth muscle cell differentiation +is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation is_a: GO:1905208 ! negative regulation of cardiocyte differentiation is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process @@ -600056,7 +596640,7 @@ name: positive regulation of cardiac vascular smooth muscle cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF] synonym: "positive regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol] -is_a: GO:1905065 ! positive regulation of vascular smooth muscle cell differentiation +is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation is_a: GO:1905209 ! positive regulation of cardiocyte differentiation is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation intersection_of: GO:0008150 ! biological_process @@ -600870,20 +597454,6 @@ relationship: part_of GO:0071456 ! cellular response to hypoxia created_by: mah creation_date: 2011-06-22T04:07:20Z -[Term] -id: GO:2000778 -name: positive regulation of interleukin-6 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion." [GOC:BHF] -synonym: "positive regulation of IL-6 secretion" EXACT [GOC:obol] -is_a: GO:0032755 ! positive regulation of interleukin-6 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0072604 ! interleukin-6 secretion -relationship: positively_regulates GO:0072604 ! interleukin-6 secretion -created_by: vk -creation_date: 2011-06-22T08:27:45Z - [Term] id: GO:2000779 name: regulation of double-strand break repair @@ -602146,7 +598716,6 @@ synonym: "regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [ synonym: "regulation of folliculin secretion" EXACT [GOC:obol] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0046883 ! regulation of hormone secretion -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0035943 ! estrone secretion relationship: regulates GO:0035943 ! estrone secretion @@ -602163,7 +598732,6 @@ synonym: "negative regulation of folliculin secretion" EXACT [GOC:obol] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:2000867 ! regulation of estrone secretion -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0035943 ! estrone secretion relationship: negatively_regulates GO:0035943 ! estrone secretion @@ -602180,7 +598748,6 @@ synonym: "positive regulation of folliculin secretion" EXACT [GOC:obol] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:2000867 ! regulation of estrone secretion -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0035943 ! estrone secretion relationship: positively_regulates GO:0035943 ! estrone secretion @@ -602194,7 +598761,6 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of progesterone secretion." [GOC:sl] is_a: GO:2000194 ! regulation of female gonad development is_a: GO:2000831 ! regulation of steroid hormone secretion -is_a: GO:2001023 ! regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0042701 ! progesterone secretion relationship: regulates GO:0042701 ! progesterone secretion @@ -602209,7 +598775,6 @@ def: "Any process that stops, prevents or reduces the frequency, rate or extent is_a: GO:2000195 ! negative regulation of female gonad development is_a: GO:2000832 ! negative regulation of steroid hormone secretion is_a: GO:2000870 ! regulation of progesterone secretion -is_a: GO:2001024 ! negative regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0042701 ! progesterone secretion relationship: negatively_regulates GO:0042701 ! progesterone secretion @@ -602224,7 +598789,6 @@ def: "Any process that activates or increases the frequency, rate or extent of p is_a: GO:2000196 ! positive regulation of female gonad development is_a: GO:2000833 ! positive regulation of steroid hormone secretion is_a: GO:2000870 ! regulation of progesterone secretion -is_a: GO:2001025 ! positive regulation of response to drug intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0042701 ! progesterone secretion relationship: positively_regulates GO:0042701 ! progesterone secretion @@ -602403,7 +598967,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of a glucom synonym: "glucomannan catabolism" EXACT [GOC:obol] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0010391 ! glucomannan metabolic process -is_a: GO:0042737 ! drug catabolic process created_by: jl creation_date: 2011-07-28T09:19:03Z @@ -602558,7 +599121,6 @@ name: regulation of glucomannan catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators] synonym: "regulation of glucomannan catabolism" EXACT [GOC:obol] -is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043470 ! regulation of carbohydrate catabolic process intersection_of: GO:0008150 ! biological_process @@ -602673,8 +599235,8 @@ name: negative regulation of glucomannan catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators] synonym: "negative regulation of glucomannan catabolism" EXACT [GOC:obol] +is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process -is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process is_a: GO:2000898 ! regulation of glucomannan catabolic process intersection_of: GO:0008150 ! biological_process @@ -604174,9 +600736,9 @@ def: "Any process that stops, prevents or reduces the frequency, rate or extent synonym: "negative regulation of pectin breakdown" EXACT [GOC:obol] synonym: "negative regulation of pectin catabolism" EXACT [GOC:obol] synonym: "negative regulation of pectin degradation" EXACT [GOC:obol] +is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process -is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:2001003 ! regulation of pectin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: negatively_regulates GO:0045490 ! pectin catabolic process @@ -604192,9 +600754,9 @@ def: "Any process that activates or increases the frequency, rate or extent of p synonym: "positive regulation of pectin breakdown" EXACT [GOC:obol] synonym: "positive regulation of pectin catabolism" EXACT [GOC:obol] synonym: "positive regulation of pectin degradation" EXACT [GOC:obol] +is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process -is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:2001003 ! regulation of pectin catabolic process intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0045490 ! pectin catabolic process @@ -604975,7 +601537,6 @@ id: GO:2001063 name: glucomannan binding namespace: molecular_function def: "Interacting selectively and non-covalently with glucomannan." [GOC:mengo_curators] -is_a: GO:0008144 ! drug binding is_a: GO:0010297 ! heteropolysaccharide binding created_by: jl creation_date: 2011-09-14T10:29:45Z @@ -605602,7 +602163,6 @@ name: coenzyme gamma-F420-2 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a coenzyme gamma-F420-2." [GOC:mengo_curators] synonym: "coenzyme gamma-F420-2 biosynthesis" EXACT [GOC:obol] -is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0052649 ! coenzyme gamma-F420-2 metabolic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process @@ -605729,7 +602289,6 @@ namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a 3-(methylthio)propionic acid." [GOC:mengo_curators] is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0009404 ! toxin metabolic process is_a: GO:0015948 ! methanogenesis created_by: jl creation_date: 2011-10-13T12:19:33Z @@ -605750,8 +602309,6 @@ name: methane biosynthetic process from carbon monoxide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a methane from a carbon monoxide." [GOC:mengo_curators] is_a: GO:0015948 ! methanogenesis -is_a: GO:0017144 ! drug metabolic process -is_a: GO:0042133 ! neurotransmitter metabolic process created_by: jl creation_date: 2011-10-13T12:36:20Z @@ -605862,8 +602419,6 @@ name: nicotinate transport namespace: biological_process def: "The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol] is_a: GO:0015718 ! monocarboxylic acid transport -is_a: GO:0015893 ! drug transport -is_a: GO:0051180 ! vitamin transport is_a: GO:0071705 ! nitrogen compound transport created_by: tb creation_date: 2011-10-18T05:09:50Z @@ -606394,106 +602949,6 @@ relationship: positively_regulates GO:0036034 ! mediator complex assembly created_by: yaf creation_date: 2011-11-02T11:22:27Z -[Term] -id: GO:2001179 -name: regulation of interleukin-10 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-10 secretion." [GOC:obol] -synonym: "regulation of IL-10 secretion" EXACT [GOC:obol] -is_a: GO:0032653 ! regulation of interleukin-10 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0072608 ! interleukin-10 secretion -relationship: regulates GO:0072608 ! interleukin-10 secretion -created_by: yaf -creation_date: 2011-11-03T10:53:48Z - -[Term] -id: GO:2001180 -name: negative regulation of interleukin-10 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion." [GOC:obol] -synonym: "negative regulation of IL-10 secretion" EXACT [GOC:obol] -is_a: GO:0032693 ! negative regulation of interleukin-10 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:2001179 ! regulation of interleukin-10 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0072608 ! interleukin-10 secretion -relationship: negatively_regulates GO:0072608 ! interleukin-10 secretion -created_by: yaf -creation_date: 2011-11-03T10:53:54Z - -[Term] -id: GO:2001181 -name: positive regulation of interleukin-10 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-10 secretion." [GOC:obol] -synonym: "positive regulation of IL-10 secretion" EXACT [GOC:obol] -is_a: GO:0032733 ! positive regulation of interleukin-10 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:2001179 ! regulation of interleukin-10 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0072608 ! interleukin-10 secretion -relationship: positively_regulates GO:0072608 ! interleukin-10 secretion -created_by: yaf -creation_date: 2011-11-03T10:53:58Z - -[Term] -id: GO:2001182 -name: regulation of interleukin-12 secretion -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of interleukin-12 secretion." [GOC:obol] -synonym: "regulation of CLMF secretion" RELATED [GOC:obol] -synonym: "regulation of IL-12 secretion" EXACT [GOC:obol] -synonym: "regulation of IL12 secretion" EXACT [GOC:obol] -synonym: "regulation of interleukin-12 complex secretion" EXACT [GOC:obol] -synonym: "regulation of NKSF secretion" RELATED [GOC:obol] -is_a: GO:0032655 ! regulation of interleukin-12 production -is_a: GO:0050707 ! regulation of cytokine secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: regulates GO:0072610 ! interleukin-12 secretion -relationship: regulates GO:0072610 ! interleukin-12 secretion -created_by: yaf -creation_date: 2011-11-03T01:10:29Z - -[Term] -id: GO:2001183 -name: negative regulation of interleukin-12 secretion -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-12 secretion." [GOC:obol] -synonym: "negative regulation of CLMF secretion" RELATED [GOC:obol] -synonym: "negative regulation of IL-12 secretion" EXACT [GOC:obol] -synonym: "negative regulation of IL12 secretion" EXACT [GOC:obol] -synonym: "negative regulation of interleukin-12 complex secretion" EXACT [GOC:obol] -synonym: "negative regulation of NKSF secretion" RELATED [GOC:obol] -is_a: GO:0032695 ! negative regulation of interleukin-12 production -is_a: GO:0050710 ! negative regulation of cytokine secretion -is_a: GO:2001182 ! regulation of interleukin-12 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: negatively_regulates GO:0072610 ! interleukin-12 secretion -relationship: negatively_regulates GO:0072610 ! interleukin-12 secretion -created_by: yaf -creation_date: 2011-11-03T01:10:37Z - -[Term] -id: GO:2001184 -name: positive regulation of interleukin-12 secretion -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of interleukin-12 secretion." [GOC:obol] -synonym: "positive regulation of CLMF secretion" RELATED [GOC:obol] -synonym: "positive regulation of IL-12 secretion" EXACT [GOC:obol] -synonym: "positive regulation of IL12 secretion" EXACT [GOC:obol] -synonym: "positive regulation of interleukin-12 complex secretion" EXACT [GOC:obol] -synonym: "positive regulation of NKSF secretion" RELATED [GOC:obol] -is_a: GO:0032735 ! positive regulation of interleukin-12 production -is_a: GO:0050715 ! positive regulation of cytokine secretion -is_a: GO:2001182 ! regulation of interleukin-12 secretion -intersection_of: GO:0008150 ! biological_process -intersection_of: positively_regulates GO:0072610 ! interleukin-12 secretion -relationship: positively_regulates GO:0072610 ! interleukin-12 secretion -created_by: yaf -creation_date: 2011-11-03T01:10:41Z - [Term] id: GO:2001185 name: regulation of CD8-positive, alpha-beta T cell activation @@ -606885,7 +603340,6 @@ synonym: "regulation of isopentenyl diphosphate synthesis, mevalonate pathway" E is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process -is_a: GO:0051196 ! regulation of coenzyme metabolic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process intersection_of: GO:0008150 ! biological_process @@ -606907,7 +603361,6 @@ synonym: "negative regulation of isopentenyl diphosphate synthesis, mevalonate p is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process -is_a: GO:0051198 ! negative regulation of coenzyme metabolic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway @@ -607127,7 +603580,6 @@ id: GO:2001227 name: quercitrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with quercitrin." [GOC:obol] -is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding is_a: GO:0097243 ! flavonoid binding is_a: GO:0097367 ! carbohydrate derivative binding @@ -608129,8 +604581,6 @@ name: codeine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [GOC:yaf] synonym: "codeine metabolism" EXACT [GOC:obol] -is_a: GO:0006805 ! xenobiotic metabolic process -is_a: GO:0017144 ! drug metabolic process is_a: GO:0033076 ! isoquinoline alkaloid metabolic process is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process created_by: pr @@ -608144,8 +604594,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of codeine, synonym: "codeine breakdown" EXACT [GOC:obol] synonym: "codeine catabolism" EXACT [GOC:obol] synonym: "codeine degradation" EXACT [GOC:obol] -is_a: GO:0042178 ! xenobiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0071274 ! isoquinoline alkaloid catabolic process is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process is_a: GO:2001291 ! codeine metabolic process @@ -608384,7 +604832,6 @@ def: "The chemical reactions and pathways involving the epipolythiodioxopiperazi synonym: "gliotoxin metabolism" EXACT [GOC:obol] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006790 ! sulfur compound metabolic process -is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0043385 ! mycotoxin metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process @@ -608399,8 +604846,6 @@ def: "The chemical reactions and pathways resulting in the breakdown of the epip synonym: "gliotoxin breakdown" EXACT [GOC:obol] synonym: "gliotoxin catabolism" EXACT [GOC:obol] synonym: "gliotoxin degradation" EXACT [GOC:obol] -is_a: GO:0017001 ! antibiotic catabolic process -is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0043387 ! mycotoxin catabolic process is_a: GO:0044273 ! sulfur compound catabolic process @@ -608421,7 +604866,6 @@ synonym: "gliotoxin biosynthesis" EXACT [GOC:obol] synonym: "gliotoxin formation" EXACT [GOC:obol] synonym: "gliotoxin synthesis" EXACT [GOC:obol] is_a: GO:0009072 ! aromatic amino acid family metabolic process -is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0043386 ! mycotoxin biosynthetic process diff --git a/resources/resource_v1.0.1.txt b/resources/resource_v1.0.2.txt similarity index 100% rename from resources/resource_v1.0.1.txt rename to resources/resource_v1.0.2.txt diff --git a/resources/web/about.html b/resources/web/about.html index ceea7f7..ce15dad 100644 --- a/resources/web/about.html +++ b/resources/web/about.html @@ -54,6 +54,13 @@ https://app.tappas.org/downloads + Or use the following text:
+
+ tappAS: a comprehensive computational framework for the analysis of the functional impact of differential splicing.

+ Lorena de la Fuente, Ángeles Arzalluz-Luque, Manuel Tardáguila, Héctor del Risco, Cristina Martí, Sonia Tarazona, Pedro Salguero, Raymond Scott, Ana Alastrue-Agudo, Pablo Bonilla, Jeremy Newman, Lauren McIntyre, Victoria Moreno-Manzano, Ana Cones.

+ Genome Biology; doi: https://doi.org/10.1186/s13059-020-02028-w +
+
diff --git a/scripts/DFI.R b/scripts/DFI.R index ad34b12..12537cc 100644 --- a/scripts/DFI.R +++ b/scripts/DFI.R @@ -113,8 +113,17 @@ DEXSeq.DS <- function(raw.counts, feature_association, factors) { bp_param <- SnowParam(workers=4); } - ##CODE to prevent error (if only have one gene (with and without) doesn't work) - if(dim(dxd)[1]<=2){return(NULL)} + ##CODE to prevent error (if only have one gene (with and without) does not work) + if((dim(dxd)[1])/2<=1){return(NULL)} + + dxd <- tryCatch({estimateDispersions(dxd, BPPARAM = bp_param)}, #try + error=function(cond){return(NA)} # error + ) + + if(is.na(dxd)){ + cat("It is possible you have a low number of genes/features and the method can not stimate the results.\n") + return(results) # low samples/genes and we can not calculate the results + } dxd <- estimateDispersions(dxd, BPPARAM = bp_param); ## Run the test and get results for exon bins @@ -467,8 +476,6 @@ for(db in dbs$db) { ### end filter if(nrow(dbcatMatrixRaw) == 0){ - print("1ºError") - print(nrow(dbcatMatrixRaw)) cont_err = cont_err + 1 next } @@ -505,6 +512,8 @@ for(db in dbs$db) { } ### end filter + cat(paste0(nrow(dbcatMatrixRaw), " isoforms remain.\n")) + if(nrow(dbcatMatrixRaw) == 0){ cont_err = cont_err + 1 cat("For the category", as.character(category), "you have 0 transcripts to analyze.") @@ -512,6 +521,7 @@ for(db in dbs$db) { catResults = DEXSeq.DS(dbcatMatrixRaw, dbcatGenes, myfactors) } } + if(is.null(catResults)){ print("Your result matrix do not have results.") len_zero = T @@ -523,13 +533,13 @@ for(db in dbs$db) { } # if we dont have trans and we dont processed any feature before -if(len_zero & cont_err == cont){ +if((len_zero & cont_err == cont) | is.null(results)){ cat("Final output\n") if(!is.null(results)) write.table(results, file.path(outdir, paste0("dfi_result.",as.character(analysisId),".tsv")), quote=FALSE, row.names=FALSE, sep="\t") # write completion file - cat("You have 0 transcripts to analyze with this feature.\n") + cat("You have 0 transcripts to analyze with this feature/s.\n") }else{ cat("Preliminary final output\n") diff --git a/scripts/DFI_TimeCourse.R b/scripts/DFI_TimeCourse.R index b9c0817..3ee1991 100644 --- a/scripts/DFI_TimeCourse.R +++ b/scripts/DFI_TimeCourse.R @@ -791,7 +791,7 @@ for(db in sources$db) { } # if we dont have trans and we dont processed any feature before -if(len_zero & cont == 0){ +if((len_zero & cont == 0) | is.null(result_dfi)){ cat("Final output\n") write.table(result_dfi, file.path(outdir, paste0("dfi_result.",as.character(analysisId),".tsv")), quote=FALSE, row.names=FALSE, sep="\t") # write completion file