diff --git a/src/toil/jobStores/ftp_utils.py b/src/toil/jobStores/ftp_utils.py
new file mode 100644
index 0000000000..894fbff3e8
--- /dev/null
+++ b/src/toil/jobStores/ftp_utils.py
@@ -0,0 +1,214 @@
+# Copyright 2017 Oregon Health and Science University
+#
+# Copyright (C) 2015-2021 Regents of the University of California
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+
+import ftplib
+import logging
+import netrc
+import os
+from contextlib import closing
+from typing import Optional, Any, cast, IO
+from urllib.parse import urlparse
+from urllib.request import urlopen
+
+logger = logging.getLogger(__name__)
+
+
+class FtpFsAccess:
+    """
+    FTP access with upload.
+
+    Taken and modified from https://github.com/ohsu-comp-bio/cwl-tes/blob/03f0096f9fae8acd527687d3460a726e09190c3a/cwl_tes/ftp.py#L37-L251
+    """
+
+    def __init__(
+        self, cache: Optional[dict[Any, ftplib.FTP]] = None, insecure: bool = False
+    ):
+        """
+        FTP object to handle FTP connections. By default, connect over FTP with TLS.
+
+        :param cache: cache of generated FTP objects
+        :param insecure: Whether to connect over FTP with TLS
+        """
+        self.cache = cache or {}
+        self.netrc = None
+        self.insecure = insecure
+        try:
+            if "HOME" in os.environ:
+                if os.path.exists(os.path.join(os.environ["HOME"], ".netrc")):
+                    self.netrc = netrc.netrc(os.path.join(os.environ["HOME"], ".netrc"))
+            elif os.path.exists(os.path.join(os.curdir, ".netrc")):
+                self.netrc = netrc.netrc(os.path.join(os.curdir, ".netrc"))
+        except netrc.NetrcParseError as err:
+            logger.debug(err)
+
+    def exists(self, fn: str) -> bool:
+        """
+        Check if a file/directory exists over an FTP server
+        :param fn: FTP url
+        :return: True or false depending on whether the object exists on the server
+        """
+        return self.isfile(fn) or self.isdir(fn)
+
+    def isfile(self, fn: str) -> bool:
+        """
+        Check if the FTP url points to a file
+        :param fn: FTP url
+        :return: True if url is file, else false
+        """
+        ftp = self._connect(fn)
+        if ftp:
+            try:
+                if not self.size(fn) is None:
+                    return True
+                else:
+                    return False
+            except ftplib.all_errors:
+                return False
+        return False
+
+    def isdir(self, fn: str) -> bool:
+        """
+        Check if the FTP url points to a directory
+        :param fn: FTP url
+        :return: True if url is directory, else false
+        """
+        ftp = self._connect(fn)
+        if ftp:
+            try:
+                cwd = ftp.pwd()
+                ftp.cwd(urlparse(fn).path)
+                ftp.cwd(cwd)
+                return True
+            except ftplib.all_errors:
+                return False
+        return False
+
+    def open(self, fn: str, mode: str) -> IO[bytes]:
+        """
+        Open an FTP url.
+
+        Only supports reading, no write support.
+        :param fn: FTP url
+        :param mode: Mode to open FTP url in
+        :return:
+        """
+        if "r" in mode:
+            host, user, passwd, path = self._parse_url(fn)
+            handle = urlopen("ftp://{}:{}@{}/{}".format(user, passwd, host, path))
+            return cast(IO[bytes], closing(handle))
+        # TODO: support write mode
+        raise Exception("Write mode FTP not implemented")
+
+    def _parse_url(
+        self, url: str
+    ) -> tuple[Optional[str], Optional[str], Optional[str], str]:
+        """
+        Parse an FTP url into hostname, username, password, and path
+        :param url:
+        :return: hostname, username, password, path
+        """
+        parse = urlparse(url)
+        user = parse.username
+        passwd = parse.password
+        host = parse.hostname
+        path = parse.path
+        if parse.scheme == "ftp":
+            if not user and self.netrc:
+                if host is not None:
+                    creds = self.netrc.authenticators(host)
+                    if creds:
+                        user, _, passwd = creds
+        if not user:
+            if host is not None:
+                user, passwd = self._recall_credentials(host)
+                if passwd is None:
+                    passwd = "anonymous@"
+                    if user is None:
+                        user = "anonymous"
+
+        return host, user, passwd, path
+
+    def _connect(self, url: str) -> Optional[ftplib.FTP]:
+        """
+        Connect to an FTP server. Handles authentication.
+        :param url: FTP url
+        :return: FTP object
+        """
+        parse = urlparse(url)
+        if parse.scheme == "ftp":
+            host, user, passwd, _ = self._parse_url(url)
+            if host is None:
+                # there has to be a host
+                return None
+            if (host, user, passwd) in self.cache:
+                if self.cache[(host, user, passwd)].pwd():
+                    return self.cache[(host, user, passwd)]
+            ftp = ftplib.FTP_TLS()
+            ftp.set_debuglevel(1 if logger.isEnabledFor(logging.DEBUG) else 0)
+            ftp.connect(host)
+            env_user = os.getenv("TOIL_FTP_USER")
+            env_passwd = os.getenv("TOIL_FTP_PASSWORD")
+            if env_user:
+                user = env_user
+            if env_passwd:
+                passwd = env_passwd
+            ftp.login(user or "", passwd or "", secure=not self.insecure)
+            self.cache[(host, user, passwd)] = ftp
+            return ftp
+        return None
+
+    def _recall_credentials(
+        self, desired_host: str
+    ) -> tuple[Optional[str], Optional[str]]:
+        """
+        Grab the cached credentials
+        :param desired_host: FTP hostname
+        :return: username, password
+        """
+        for host, user, passwd in self.cache:
+            if desired_host == host:
+                return user, passwd
+        return None, None
+
+    def size(self, fn: str) -> Optional[int]:
+        """
+        Get the size of an FTP object
+        :param fn: FTP url
+        :return: Size of object
+        """
+        ftp = self._connect(fn)
+        if ftp:
+            host, user, passwd, path = self._parse_url(fn)
+            try:
+                return ftp.size(path)
+            except ftplib.all_errors as e:
+                if str(e) == "550 SIZE not allowed in ASCII mode":
+                    # some servers don't allow grabbing size in ascii mode
+                    # https://stackoverflow.com/questions/22090001/get-folder-size-using-ftplib/22093848#22093848
+                    ftp.voidcmd("TYPE I")
+                    return ftp.size(path)
+                if host is None:
+                    # no host
+                    return None
+                handle = urlopen("ftp://{}:{}@{}/{}".format(user, passwd, host, path))
+                info = handle.info()
+                handle.close()
+                if "Content-length" in info:
+                    return int(info["Content-length"])
+                return None
+
+        return None