diff --git a/eslint-plugin-expensify/CONST.js b/eslint-plugin-expensify/CONST.js
index 9c273b5..456be1f 100644
--- a/eslint-plugin-expensify/CONST.js
+++ b/eslint-plugin-expensify/CONST.js
@@ -8,6 +8,7 @@ module.exports = {
         NO_NEGATED_VARIABLES: 'Do not use negated variable names.',
         NO_THENABLE_ACTIONS_IN_VIEWS: 'Calling .then() on action method {{method}} is forbidden in React views. Relocate this logic into the actions file and pass values via Onyx.',
         NO_USELESS_COMPOSE: 'compose() is not necessary when passed a single argument',
+        NO_MULTIPLE_ONYX_IN_FILE: 'Only use withOnyx() once. Read here about how to properly work with dependent Onyx keys: https://github.com/Expensify/react-native-onyx#dependent-onyx-keys-and-withonyx',
         PREFER_ACTIONS_SET_DATA: 'Only actions should directly set or modify Onyx data. Please move this logic into a suitable action.',
         PREFER_EARLY_RETURN: 'Prefer an early return to a conditionally-wrapped function body',
         PREFER_IMPORT_MODULE_CONTENTS: 'Do not import individual exports from local modules. Prefer \'import * as\' syntax.',
diff --git a/eslint-plugin-expensify/no-multiple-onyx-in-file.js b/eslint-plugin-expensify/no-multiple-onyx-in-file.js
new file mode 100644
index 0000000..e22ddd8
--- /dev/null
+++ b/eslint-plugin-expensify/no-multiple-onyx-in-file.js
@@ -0,0 +1,28 @@
+const lodashGet = require('lodash/get');
+const message = require('./CONST').MESSAGE.NO_MULTIPLE_ONYX_IN_FILE;
+
+module.exports = {
+    create: (context) => {
+        let withOnyxCount = 0;
+
+        return {
+            CallExpression(node) {
+                const calleeName = lodashGet(node, 'callee.name');
+
+                if (calleeName === 'withOnyx') {
+                    withOnyxCount += 1;
+
+                    if (withOnyxCount > 1) {
+                        context.report({
+                            node,
+                            message,
+                        });
+                    }
+                }
+            },
+            'Program:exit': () => {
+                withOnyxCount = 0;
+            },
+        };
+    },
+};
diff --git a/eslint-plugin-expensify/tests/no-multiple-onyx-in-file.test.js b/eslint-plugin-expensify/tests/no-multiple-onyx-in-file.test.js
new file mode 100644
index 0000000..340074c
--- /dev/null
+++ b/eslint-plugin-expensify/tests/no-multiple-onyx-in-file.test.js
@@ -0,0 +1,43 @@
+const RuleTester = require('eslint').RuleTester;
+const rule = require('../no-multiple-onyx-in-file');
+const message = require('../CONST').MESSAGE.NO_MULTIPLE_ONYX_IN_FILE;
+
+const ruleTester = new RuleTester({
+    parserOptions: {
+        ecmaVersion: 6,
+        sourceType: 'module',
+    },
+});
+
+ruleTester.run('no-multiple-onyx-in-file', rule, {
+    valid: [
+        {
+            code: `
+                compose(
+                    withOnyx({
+                        key: 'value',
+                    })
+                )(Component);
+            `,
+        },
+    ],
+    invalid: [
+        {
+            code: `
+                compose(
+                    withOnyx({
+                        key1: 'value1',
+                    }),
+                    withOnyx({
+                        key1: 'value1',
+                    })
+                )(Component);
+            `,
+            errors: [
+                {
+                    message,
+                },
+            ],
+        },
+    ],
+});
diff --git a/package.json b/package.json
index 73d480f..298eb7e 100644
--- a/package.json
+++ b/package.json
@@ -1,6 +1,6 @@
 {
   "name": "eslint-config-expensify",
-  "version": "2.0.38",
+  "version": "2.0.39",
   "description": "Expensify's ESLint configuration following our style guide",
   "main": "index.js",
   "repository": {
diff --git a/rules/expensify.js b/rules/expensify.js
index e447efa..e9fc647 100644
--- a/rules/expensify.js
+++ b/rules/expensify.js
@@ -11,6 +11,7 @@ module.exports = {
         'rulesdir/no-useless-compose': 'error',
         'rulesdir/prefer-import-module-contents': 'error',
         'rulesdir/no-multiple-api-calls': 'error',
+        'rulesdir/no-multiple-onyx-in-file': 'error',
         'rulesdir/no-call-actions-from-actions': 'error',
         'rulesdir/no-api-side-effects-method': 'error',
         'rulesdir/display-name-property': 'error',