Skip to content

Latest commit

 

History

History
23 lines (15 loc) · 1.21 KB

README.md

File metadata and controls

23 lines (15 loc) · 1.21 KB

Metabolomics_signature

In this notebook I will generate the figures in my paper entitled "Bioinformatics Analysis of Metabolomics Data Unveils Association of Metabolic Signatures with Methylation in Breast Cancer". We want to cluster patients based on their metabolome profiles, then assign significant metabolites to these clusters. We will implement the below pipeline: Image description The whole process is in the below Jupyter notebook for dataset1 using k=4: https://nbviewer.jupyter.org/github/FADHLyemen/Metabolomics_signature/blob/master/notebook/Notebook%20data1/four%20clusters/Metabolomics_signature-v1_kmeans_pam_data1_four_clusters.ipynb

dataset1 using k=3: https://nbviewer.jupyter.org/github/FADHLyemen/Metabolomics_signature/blob/master/notebook/Notebook%20data1/three%20clusters/Metabolomics_signature-v1_kmeans_pam_data1_three_clusters.ipynb

dataset2 using k=3: https://nbviewer.jupyter.org/github/FADHLyemen/Metabolomics_signature/blob/master/notebook/Notebook%20data2/Metabolomics_signature-v1_kmeans_pam_data2.ipynb

dataset1:

https://ars.els-cdn.com/content/image/1-s2.0-S1874391913005113-mmc2.xls

dataset2:

https://dm5migu4zj3pb.cloudfront.net/manuscripts/71000/71180/JCI71180sd2.xlsx