diff --git a/src/Foundatio.TestHarness/Caching/CacheClientTestsBase.cs b/src/Foundatio.TestHarness/Caching/CacheClientTestsBase.cs
index e95d892d..71d7cc81 100644
--- a/src/Foundatio.TestHarness/Caching/CacheClientTestsBase.cs
+++ b/src/Foundatio.TestHarness/Caching/CacheClientTestsBase.cs
@@ -384,6 +384,78 @@ public virtual async Task CanRemoveByPrefixAsync()
         }
     }
 
+    public virtual async Task CanRemoveByPrefixWithScopedCachesAsync()
+    {
+        var cache = GetCacheClient();
+        if (cache == null)
+            return;
+
+        using (cache)
+        {
+            await cache.RemoveAllAsync();
+            var scopedCache1 = new ScopedCacheClient(cache, "scoped1");
+
+            const string cacheKey = "key";
+            await cache.SetAsync(cacheKey, 1);
+            await scopedCache1.SetAsync(cacheKey, 1);
+            Assert.Equal(1, (await cache.GetAsync<int>(cacheKey)).Value);
+            Assert.Equal(1, (await scopedCache1.GetAsync<int>(cacheKey)).Value);
+
+            // Remove by prefix should only remove the unscoped cache.
+            Assert.Equal(1, await cache.RemoveByPrefixAsync(cacheKey));
+            Assert.False(await cache.ExistsAsync(cacheKey));
+            Assert.True(await scopedCache1.ExistsAsync(cacheKey));
+            Assert.Equal(1, (await scopedCache1.GetAsync<int>(cacheKey)).Value);
+
+            // Add the unscoped cache value back.
+            await cache.SetAsync(cacheKey, 1);
+
+            // Remove by null key.
+            Assert.Equal(1, await scopedCache1.RemoveByPrefixAsync(null));
+            Assert.True(await cache.ExistsAsync(cacheKey));
+            Assert.False(await scopedCache1.ExistsAsync(cacheKey));
+
+            // Add the scoped cache value back.
+            await scopedCache1.SetAsync(cacheKey, 1);
+
+            Assert.Equal(2, await cache.RemoveByPrefixAsync(null));
+            Assert.False(await cache.ExistsAsync(cacheKey));
+            Assert.False(await scopedCache1.ExistsAsync(cacheKey));
+
+            // Reset client values
+            await cache.SetAsync(cacheKey, 1);
+            await scopedCache1.SetAsync(cacheKey, 1);
+
+            // Remove by empty key.
+            Assert.Equal(1, await scopedCache1.RemoveByPrefixAsync(String.Empty));
+            Assert.True(await cache.ExistsAsync(cacheKey));
+            Assert.False(await scopedCache1.ExistsAsync(cacheKey));
+
+            // Add the scoped cache value back.
+            await scopedCache1.SetAsync(cacheKey, 1);
+
+            Assert.Equal(2, await cache.RemoveByPrefixAsync(String.Empty));
+            Assert.False(await cache.ExistsAsync(cacheKey));
+            Assert.False(await scopedCache1.ExistsAsync(cacheKey));
+
+            // Reset client values
+            await cache.SetAsync(cacheKey, 1);
+            await scopedCache1.SetAsync(cacheKey, 1);
+
+            // Remove by *.
+            Assert.Equal(1, await scopedCache1.RemoveByPrefixAsync("*"));
+            Assert.True(await cache.ExistsAsync(cacheKey));
+            Assert.False(await scopedCache1.ExistsAsync(cacheKey));
+
+            // Reset client values
+            await scopedCache1.SetAsync(cacheKey, 1);
+
+            Assert.Equal(2, await cache.RemoveByPrefixAsync("*"));
+            Assert.False(await cache.ExistsAsync(cacheKey));
+            Assert.False(await scopedCache1.ExistsAsync(cacheKey));
+        }
+    }
+
     public virtual async Task CanRemoveByPrefixMultipleEntriesAsync(int count)
     {
         var cache = GetCacheClient();
diff --git a/src/Foundatio.TestHarness/Caching/HybridCacheClientTests.cs b/src/Foundatio.TestHarness/Caching/HybridCacheClientTests.cs
index 9e85bf70..34871750 100644
--- a/src/Foundatio.TestHarness/Caching/HybridCacheClientTests.cs
+++ b/src/Foundatio.TestHarness/Caching/HybridCacheClientTests.cs
@@ -87,6 +87,12 @@ public override Task CanRemoveByPrefixAsync()
         return base.CanRemoveByPrefixAsync();
     }
 
+    [Fact]
+    public override Task CanRemoveByPrefixWithScopedCachesAsync()
+    {
+        return base.CanRemoveByPrefixWithScopedCachesAsync();
+    }
+
     [Theory]
     [InlineData(50)]
     [InlineData(500)]
diff --git a/src/Foundatio/Caching/InMemoryCacheClient.cs b/src/Foundatio/Caching/InMemoryCacheClient.cs
index 1d746877..20ac10ba 100644
--- a/src/Foundatio/Caching/InMemoryCacheClient.cs
+++ b/src/Foundatio/Caching/InMemoryCacheClient.cs
@@ -182,7 +182,8 @@ public Task<int> RemoveAllAsync(IEnumerable<string> keys = null)
     public Task<int> RemoveByPrefixAsync(string prefix)
     {
         var keysToRemove = new List<string>();
-        var regex = new Regex(String.Concat(prefix, "*").Replace("*", ".*").Replace("?", ".+"));
+        string normalizedPrefix = String.IsNullOrWhiteSpace(prefix) ? "*" : prefix.Trim();
+        var regex = new Regex(String.Concat("^", Regex.Escape(normalizedPrefix.Contains("*") ? normalizedPrefix : $"{normalizedPrefix}*"), "$").Replace("\\*", ".*?"));
         try
         {
             foreach (string key in _memory.Keys.ToList())
diff --git a/tests/Foundatio.Tests/Caching/InMemoryCacheClientTests.cs b/tests/Foundatio.Tests/Caching/InMemoryCacheClientTests.cs
index 48f36669..b98bca34 100644
--- a/tests/Foundatio.Tests/Caching/InMemoryCacheClientTests.cs
+++ b/tests/Foundatio.Tests/Caching/InMemoryCacheClientTests.cs
@@ -83,6 +83,12 @@ public override Task CanRemoveByPrefixAsync()
         return base.CanRemoveByPrefixAsync();
     }
 
+    [Fact]
+    public override Task CanRemoveByPrefixWithScopedCachesAsync()
+    {
+        return base.CanRemoveByPrefixWithScopedCachesAsync();
+    }
+
     [Theory]
     [InlineData(50)]
     [InlineData(500)]
diff --git a/tests/Foundatio.Tests/Caching/InMemoryHybridCacheClientTests.cs b/tests/Foundatio.Tests/Caching/InMemoryHybridCacheClientTests.cs
index 6e00af01..27c9091a 100644
--- a/tests/Foundatio.Tests/Caching/InMemoryHybridCacheClientTests.cs
+++ b/tests/Foundatio.Tests/Caching/InMemoryHybridCacheClientTests.cs
@@ -40,6 +40,12 @@ public override Task CanRemoveByPrefixAsync()
         return base.CanRemoveByPrefixAsync();
     }
 
+    [Fact]
+    public override Task CanRemoveByPrefixWithScopedCachesAsync()
+    {
+        return base.CanRemoveByPrefixWithScopedCachesAsync();
+    }
+
     [Theory]
     [InlineData(50)]
     [InlineData(500)]