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thesis_bibliography.bib
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thesis_bibliography.bib
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% This file was created with JabRef 2.4.2.
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@ARTICLE{Alloway2000,
author = {P. G. Alloway and L. Howard and P. J. Dolph},
title = {The formation of stable rhodopsin-arrestin complexes induces apoptosis
and photoreceptor cell degeneration.},
journal = {Neuron},
year = {2000},
volume = {28},
pages = {129--138},
number = {1},
month = {Oct},
abstract = {Although many different mutations in humans and Drosophila cause retinal
degeneration, in most cases, a molecular mechanism for the degeneration
has not been found. We now demonstrate the existence of stable, persistent
complexes between rhodopsin and its regulatory protein arrestin in
several different retinal degeneration mutants. Elimination of these
rhodopsin-arrestin complexes by removing either rhodopsin or arrestin
rescues the degeneration phenotype. Furthermore, we show that the
accumulation of these complexes triggers apoptotic cell death and
that the observed retinal degeneration requires the endocytic machinery.
This suggests that the endocytosis of rhodopsin-arrestin complexes
is a molecular mechanism for the initiation of retinal degeneration.
We propose that an identical mechanism may be responsible for the
pathology found in a subset of human retinal degenerative disorders.},
institution = {Department of Biological Sciences, Dartmouth College, Hanover, New
Hampshire 03755, USA.},
keywords = {Animals; Apoptosis; Arrestin, metabolism; Arrestins, genetics; Drosophila;
Drosophila Proteins; Endocytosis; Eye Proteins; Light, adverse effects;
Membrane Proteins, genetics; Mutation; Phosphatidylinositol Diacylglycerol-Lyase;
Phosphoproteins, genetics; Phosphorylation; Photoreceptor Cells,
Invertebrate, metabolism/pathology; Retinal Degeneration, genetics/metabolism/pathology;
Rhodopsin, metabolism; Type C Phospholipases, genetics},
owner = {jianhong ou},
pii = {S0896-6273(00)00091-X},
pmid = {11086989},
timestamp = {2009.11.27}
}
@ARTICLE{Bilen2005,
author = {Julide Bilen and Nancy M Bonini},
title = {Drosophila as a model for human neurodegenerative disease.},
journal = {Annu Rev Genet},
year = {2005},
volume = {39},
pages = {153--171},
abstract = {Among many achievements in the neurodegeneration field in the past
decade, two require special attention due to the huge impact on our
understanding of molecular and cellular pathogenesis of human neurodegenerative
diseases. First is defining specific mutations in familial neurodegenerative
diseases and second is modeling these diseases in easily manipulable
model organisms including the fruit fly, nematode, and yeast. The
power of these genetic systems has revealed many genetic factors
involved in the various pathways affected, as well as provided potential
drug targets for therapeutics. This review focuses on fruit fly models
of human neurodegenerative diseases, with emphasis on how fly models
have provided new insights into various aspects of human diseases.},
doi = {10.1146/annurev.genet.39.110304.095804},
institution = {Department of Biology, University of Pennsylvania, Philadelphia,
Pennsylvania 19104, USA.},
keywords = {Alzheimer Disease, genetics/physiopathology; Animals; Disease Models,
Animal; Drosophila melanogaster, genetics/physiology; Humans; Neurodegenerative
Diseases, genetics/physiopathology; Parkinson Disease, genetics/physiopathology;
Trinucleotide Repeats, genetics/physiology},
owner = {jianhong ou},
pmid = {16285856},
timestamp = {2009.11.28}
}
@ARTICLE{Blackshaw2001,
author = {S. Blackshaw and R. E. Fraioli and T. Furukawa and C. L. Cepko},
title = {Comprehensive analysis of photoreceptor gene expression and the identification
of candidate retinal disease genes.},
journal = {Cell},
year = {2001},
volume = {107},
pages = {579--589},
number = {5},
month = {Nov},
abstract = {To identify the full set of genes expressed by mammalian rods, we
conducted serial analysis of gene expression (SAGE) by using libraries
generated from mature and developing mouse retina. We identified
264 uncharacterized genes that were specific to or highly enriched
in rods. Nearly half of all cloned human retinal disease genes are
selectively expressed in rod photoreceptors. In silico mapping of
the human orthologs of genes identified in our screen revealed that
86 map within intervals containing uncloned retinal disease genes,
representing 37 different loci. We expect these data will allow identification
of many disease genes, and that this approach may be useful for cloning
genes involved in classes of disease where cell type-specific expression
of disease genes is observed.},
institution = {Department of Genetics, Howard Hughes Medical Institute, Harvard
Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.},
keywords = {Animals; Blotting, Northern; Expressed Sequence Tags; Gene Expression
Profiling, methods; Gene Expression Regulation; Gene Library; Homeodomain
Proteins, genetics/metabolism; Humans; Hypothalamus, physiology;
In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout;
RNA, Messenger, genetics/metabolism; Retina, cytology/physiology;
Retinal Diseases, genetics; Retinal Rod Photoreceptor Cells, physiology;
Trans-Activators, genetics/metabolism},
owner = {jianhong ou},
pii = {S0092-8674(01)00574-8},
pmid = {11733058},
timestamp = {2009.11.28}
}
@ARTICLE{Bloomquist1988,
author = {B. T. Bloomquist and R. D. Shortridge and S. Schneuwly and M. Perdew
and C. Montell and H. Steller and G. Rubin and W. L. Pak},
title = {Isolation of a putative phospholipase C gene of Drosophila, norpA,
and its role in phototransduction.},
journal = {Cell},
year = {1988},
volume = {54},
pages = {723--733},
number = {5},
month = {Aug},
abstract = {Severe norpA mutations in Drosophila eliminate the photoreceptor potential
and render the fly completely blind. Recent biochemical analyses
have shown that norpA mutants lack phospholipase C (PLC) activity
in the eye. A combination of chromosomal walking and transposon-mediated
mutagenesis was used to clone the norpA gene. This gene encodes a
7.5 kb RNA that is expressed in the adult head. In situ hybridizations
of norpA cDNA to adult tissue sections show that this gene is expressed
abundantly in the retina. The putative norpA protein is composed
of 1095 amino acid residues and has extensive sequence similarity
to a PLC amino acid sequence from bovine brain. We suggest that the
norpA gene encodes a PLC expressed in the eye of Drosophila and that
PLC is an essential component of the Drosophila phototransduction
pathway.},
institution = {Department of Biological Sciences, Purdue University, West Lafayette,
Indiana 47907.},
keywords = {Amino Acid Sequence; Animals; Base Sequence; Brain, enzymology; Cattle;
Chromosome Mapping; Cloning, Molecular; DNA Restriction Enzymes;
DNA, genetics/isolation /&/ purification; Drosophila melanogaster,
genetics/physiology; Genes; Molecular Sequence Data; Mutation; Photoreceptor
Cells, physiology; RNA, genetics/isolation /&/ purification; Sequence
Homology, Nucleic Acid; Type C Phospholipases, genetics},
owner = {jianhong ou},
pii = {S0092-8674(88)80017-5},
pmid = {2457447},
timestamp = {2009.11.28}
}