diff --git a/snudda/simulate/simulate.py b/snudda/simulate/simulate.py
index 298f381cc..69cdc314e 100644
--- a/snudda/simulate/simulate.py
+++ b/snudda/simulate/simulate.py
@@ -156,6 +156,8 @@ def __init__(self,
         self.node_id = int(self.pc.id())
         self.total_nodes = int(self.pc.nhost())
 
+        self.post_init_mods = dict()
+
         comm = MPI.COMM_WORLD
         rank = comm.Get_rank()
         size = comm.Get_size()
@@ -240,6 +242,9 @@ def __init__(self,
                 self.current_injection_info |= self.sim_info["current_injection_info"]
                 self.write_log(f"Updating current_injection_info from config file")
 
+            if "post_init_modifications" in self.sim_info:
+                self.post_init_mods = self.sim_info["post_init_modifications"]
+
         else:
             self.sim_info = None
 
@@ -837,6 +842,10 @@ def setup_neurons(self):
                     and self.neurons[neuron_id].modulation is not None:
                 self.neurons[neuron_id].modulation.build_node_cache()
 
+        # This allows us to modify ion channel conductance on the fly before runnigg simulation
+        # Can be useful to e.g. increase KIR channel conductance
+        self.post_initialisation_modifications()
+
     ############################################################################
 
     def connect_network(self):
@@ -2144,6 +2153,29 @@ def sanity_check_play_vectors(self, sim_end_time):
                 raise ValueError(f"Simulation duration {sim_end_time} is "
                                  f"longer than time vector for bath application of {species_name}")
 
+    def post_initialisation_modifications(self):
+
+        if len(self.post_init_mods) == 0:
+            return
+
+        print(f"Applying post_initialisation_modifications")
+        # This allows us to modify ion channel conductance on the fly before runnigg simulation
+        # Can be useful to e.g. increase KIR channel conductance
+
+        for n in self.neurons.values():
+            try:
+                if n.type in self.post_init_mods:
+                    for ion_channel, channel_mod_factor in self.post_init_mods[n.type].items():
+                        for sec in n.icell.all:
+                            for seg in sec:
+                                channel = getattr(seg, ion_channel, None)
+                                setattr(channel, "gbar", getattr(channel, "gbar") * channel_mod_factor)
+            except:
+                import traceback
+                self.write_log(traceback.format_exc())
+                import pdb
+                pdb.set_trace()
+
     def run(self, t=None, hold_v=None):
 
         """ Run simulation. """