diff --git a/Formula/l/luau.rb b/Formula/l/luau.rb
index 9b84a8a790c15..9fc8607c842c4 100644
--- a/Formula/l/luau.rb
+++ b/Formula/l/luau.rb
@@ -1,8 +1,8 @@
 class Luau < Formula
   desc "Fast, safe, gradually typed embeddable scripting language derived from Lua"
   homepage "https://luau-lang.org"
-  url "https://github.com/luau-lang/luau/archive/refs/tags/0.642.tar.gz"
-  sha256 "cc7954979d2b1f6a138a9b0cb0f2d27e3c11d109594379551bc290c0461965ba"
+  url "https://github.com/luau-lang/luau/archive/refs/tags/0.643.tar.gz"
+  sha256 "069702be7646917728ffcddcc72dae0c4191b95dfe455c8611cc5ad943878d3d"
   license "MIT"
   version_scheme 1
   head "https://github.com/luau-lang/luau.git", branch: "master"
@@ -13,14 +13,12 @@ class Luau < Formula
   end
 
   bottle do
-    sha256 cellar: :any_skip_relocation, arm64_sequoia:  "31d32c14dac829ec421d224b3a0676fb258beee9293e8de8cba3e602d31936bb"
-    sha256 cellar: :any_skip_relocation, arm64_sonoma:   "6cdc703190df61105a7ba9f2266bf8c62b03376ece42af49a19759675f6996cb"
-    sha256 cellar: :any_skip_relocation, arm64_ventura:  "2981c6bb606bb83a177cb0db8830dba0b7b68e7c5f4c7442aa554ab1bfaef87d"
-    sha256 cellar: :any_skip_relocation, arm64_monterey: "77a1cfcd7faf586a3ed23f44b371420a7f745d40aea3614eecff78cf892777ea"
-    sha256 cellar: :any_skip_relocation, sonoma:         "b3a1b754f45cc6590f7eefff68aeff37537f4097750cec1a65eb9eaad17eb866"
-    sha256 cellar: :any_skip_relocation, ventura:        "72e67586be8fa2be29df2420618f11201bb0d3a5f36432aabecf4cb0c3109ae4"
-    sha256 cellar: :any_skip_relocation, monterey:       "f1abfbf98bd70d1e615d5a85ce30d6e426fcdf42dcd1b6ec6a74902f07c9d287"
-    sha256 cellar: :any_skip_relocation, x86_64_linux:   "1181e4b8b317c456863c1aa9e0def0a437057a559605c105d42d6e21b74ad42f"
+    sha256 cellar: :any_skip_relocation, arm64_sequoia: "4552d10fb5efb2b4849f4ce088f8cb0391687c1b26d84b2e444c19a8c71142a1"
+    sha256 cellar: :any_skip_relocation, arm64_sonoma:  "9291a450c6754964f845e329bd9b7a16a8fad035fe3e34009b2dd187b68b9b7f"
+    sha256 cellar: :any_skip_relocation, arm64_ventura: "b4794fb73ec744035c1c87f9e2a8d71ca224cb9de024acea7043eb039226c918"
+    sha256 cellar: :any_skip_relocation, sonoma:        "2e538a986a0435b0e77157e41054035dd41ab51e1c2f19bc9ba73e84164ae2bb"
+    sha256 cellar: :any_skip_relocation, ventura:       "ef5787222a9c63baa82352d4fffcd5a76273b16a0f3dc7ade0a8998522227e07"
+    sha256 cellar: :any_skip_relocation, x86_64_linux:  "b7b7357cede45f8fb82c81d5476a20b3fc2e46db9fca33d8f043780147d774f6"
   end
 
   depends_on "cmake" => :build