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Untitled Diagram.drawio
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<mxCell id="o0szKlHt9puFOY36pzJz-42" value="<div><b>Exposed group</b></div><div>Exposed to liver protective agents</div><div>(N=2,886)<br></div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;" parent="1" vertex="1">
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<mxCell id="JQ605SI2x8LaLIvw7eop-1" value="<div><b>Reference group</b></div><div>Unexposed to liver protective agnets</div><div>(N=3,857)<br></div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;" parent="1" vertex="1">
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<mxCell id="JQ605SI2x8LaLIvw7eop-2" value="<div align="left">1. Cured N=833 (28.9%)</div><div align="left">2. Treatment completed N= 1634 (56.6%)</div><div align="left">3. ADR N=11 (0.4%)</div><div align="left">4. Lost to follow-up N=287 (9.9%)</div><div align="left">5. MDR-TB N=33 (1.3%)</div><div align="left">6. TB-related death N=11 (0.4%)</div><div align="left">7. Non-TB related death N=38 (1.3%)</div><div align="left">8. Treatment failure N=39 (1.4%)</div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;" parent="1" vertex="1">
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<mxCell id="JQ605SI2x8LaLIvw7eop-8" value="<div align="left">1. Cured N=1190 (30.9%)</div><div align="left">2. Treatment completed N= 2102 (54.5%)</div><div align="left">3. ADR N=11 (0.3%)</div><div align="left">4. Lost to follow-up N=375 (9.7%)</div><div align="left">5. MDR-TB N=41 (1.1%)</div><div align="left">6. TB-related death N=14 (0.6%)</div><div align="left">7. Non-TB related death N=51 (1.3%)</div><div align="left">8. Treatment failure N=73 (1.9%)</div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;" parent="1" vertex="1">
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<mxCell id="JQ605SI2x8LaLIvw7eop-10" value="<div align="left"><ol><li>DILI&nbsp;&nbsp;&nbsp;&nbsp; N=376</li><ol><li>Grade 1: N=208</li><li>Grade 2: N=5</li><li>Grade 3: N=0</li><li>Grade 4: N=2</li><li>Grade 5: N=0</li><li>Grade undetermined: N=161<br></li></ol><li>Death without DILI N=47</li><li>Lost to follow-up N=2463</li></ol></div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;" parent="1" vertex="1">
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<mxCell id="JQ605SI2x8LaLIvw7eop-12" value="<div align="left"><ol><li>DILI&nbsp;&nbsp;&nbsp;&nbsp; N=405</li><ol><li>Grade 1: N=195</li><li>Grade 2: N=7</li><li>Grade 3: N=3</li><li>Grade 4: N=2</li><li>Grade 5: N=0</li><li>Grade undetermined: N=198<br></li></ol><li>Death without DILI N=64</li><li>Lost to follow-up N=3388</li></ol></div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;align=left;" parent="1" vertex="1">
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<mxCell id="3JXMQ5Bp0BYpiOlJHczw-5" value="<div>Patients with TB identified&nbsp; from <br></div><div>Ningbo regional EHR system<br></div><div>(01/01/2010-06/30/2020)</div><div><div>(N=19,916)</div></div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;" vertex="1" parent="1">
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<mxCell id="3JXMQ5Bp0BYpiOlJHczw-7" value="<div>Patients with TB identifed from Ningbo CDC registries</div><div>(01/01/2015-12/31/2019)<br></div><div>(N=12,174)<br></div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;" vertex="1" parent="1">
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<mxCell id="3JXMQ5Bp0BYpiOlJHczw-9" style="edgeStyle=orthogonalEdgeStyle;rounded=0;orthogonalLoop=1;jettySize=auto;html=1;exitX=0.5;exitY=1;exitDx=0;exitDy=0;entryX=0;entryY=0.5;entryDx=0;entryDy=0;" edge="1" parent="1" source="3JXMQ5Bp0BYpiOlJHczw-10" target="3JXMQ5Bp0BYpiOlJHczw-11">
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<mxCell id="3JXMQ5Bp0BYpiOlJHczw-10" value="<div>Patients linked with both data sources<br></div><div>(N=12,087)<br></div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;" vertex="1" parent="1">
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<mxCell id="3JXMQ5Bp0BYpiOlJHczw-11" value="<div align="left">Excluded (N=5,344)</div><ul><li>Initial TB diagnosis changed (N=406)</li><li>Lack of at least two healthcare encounter at baseline period (N=1,558)</li><li>Lack of healthcare encounter during follow-up (N=14)</li><li>Age at index date &lt;18 years (N=140)</li><li>Evidence of pregnancy status at baseline (N=151)</li><li>Evidence of liver diseases at baseline (N=562)</li><li>Abnormal lab liver function results<br>(N=1,668)</li><li>Exposure to investigative drugs during baseline wash-out period (-365 day ~-31 day pre-index) (N=521)<br></li></ul>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;align=left;" vertex="1" parent="1">
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<mxCell id="3JXMQ5Bp0BYpiOlJHczw-12" value="<div>Analytic study cohort<br></div><div>(N=6,743)<br></div>" style="rounded=0;whiteSpace=wrap;html=1;strokeWidth=2;" vertex="1" parent="1">
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