diff --git a/.github/workflows/check-code-style.yml b/.github/workflows/check-code-style.yml
index c97d109ab..cca748da6 100644
--- a/.github/workflows/check-code-style.yml
+++ b/.github/workflows/check-code-style.yml
@@ -24,7 +24,7 @@ env:
   # We need compile command database in order to perform clang-tidy check. So,
   # in order to perform configure step we need to setup llvm-dev package. This
   # env variable used to specify desired version of it
-  LLVM_VERSION: 20
+  LLVM_VERSION: 21
 
 jobs:
   clang-format-and-tidy:
diff --git a/.github/workflows/check-in-tree-build.yml b/.github/workflows/check-in-tree-build.yml
index 31f28b7ea..b4d6d4e21 100644
--- a/.github/workflows/check-in-tree-build.yml
+++ b/.github/workflows/check-in-tree-build.yml
@@ -32,7 +32,7 @@ on:
     - cron: 0 0 * * *
 
 env:
-  LLVM_VERSION: 20
+  LLVM_VERSION: 21
 
 jobs:
   build_and_test_linux:
diff --git a/.github/workflows/check-out-of-tree-build.yml b/.github/workflows/check-out-of-tree-build.yml
index f0106b422..26ee70143 100644
--- a/.github/workflows/check-out-of-tree-build.yml
+++ b/.github/workflows/check-out-of-tree-build.yml
@@ -29,7 +29,7 @@ on:
     - cron: 0 0 * * *
 
 env:
-  LLVM_VERSION: 20
+  LLVM_VERSION: 21
 
 jobs:
   build_and_test:
diff --git a/CMakeLists.txt b/CMakeLists.txt
index e8eae2484..f9f9de4c6 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -1,7 +1,7 @@
 cmake_minimum_required(VERSION 3.13.4)
 
 if(NOT DEFINED BASE_LLVM_VERSION)
-  set (BASE_LLVM_VERSION 20.0.0)
+  set (BASE_LLVM_VERSION 21.0.0)
 endif(NOT DEFINED BASE_LLVM_VERSION)
 set(LLVM_SPIRV_VERSION ${BASE_LLVM_VERSION}.0)
 
diff --git a/README.md b/README.md
index baa0ebc2d..be50f441c 100644
--- a/README.md
+++ b/README.md
@@ -30,7 +30,7 @@ The translator can be built with the latest(nightly) package of LLVM. For Ubuntu
 wget -O - https://apt.llvm.org/llvm-snapshot.gpg.key | sudo apt-key add -
 sudo add-apt-repository "deb http://apt.llvm.org/xenial/ llvm-toolchain-xenial main"
 sudo apt-get update
-sudo apt-get install llvm-20-dev llvm-20-tools clang-20 libclang-20-dev
+sudo apt-get install llvm-21-dev llvm-21-tools clang-21 libclang-21-dev
 ```
 The installed version of LLVM will be used by default for out-of-tree build of the translator.
 ```
@@ -157,7 +157,7 @@ make test
 ```
 This requires that the `-DLLVM_SPIRV_INCLUDE_TESTS=ON` argument is
 passed to CMake during the build step. Additionally,
-`-DLLVM_EXTERNAL_LIT="/usr/lib/llvm-20/build/utils/lit/lit.py"` is
+`-DLLVM_EXTERNAL_LIT="/usr/lib/llvm-21/build/utils/lit/lit.py"` is
 needed when building with a pre-installed version of LLVM.
 
 The translator test suite can be disabled by passing