diff --git a/esm.mjs b/esm.mjs
new file mode 100755
index 00000000..29f4af0f
--- /dev/null
+++ b/esm.mjs
@@ -0,0 +1,13 @@
+import { fileURLToPath } from 'url';
+import { createRequire } from 'module';
+const require = createRequire(fileURLToPath(import.meta.url));
+
+/** @type {import('./src/compatibility/node-register')} */
+const { nodeRegister } = require('./dist/compatibility/node-register');
+
+/** @type {import('ts-node')} */
+import tsNode from 'ts-node';
+
+const tsNodeInstance = nodeRegister();
+
+export const { resolve, getFormat, transformSource } = tsNode.createEsmHooks(tsNodeInstance);
diff --git a/package.json b/package.json
index bb2ced5d..d68228a9 100755
--- a/package.json
+++ b/package.json
@@ -64,7 +64,7 @@
     "rimraf": "^3.0.2",
     "standard-version": "^9.3.1",
     "ts-jest": "^27.0.4",
-    "ts-node": "^10.1.0",
+    "ts-node": "^10.4.0",
     "ts-patch": "^1.4.4",
     "ts3": "npm:typescript@3.7.7",
     "ts45": "npm:typescript@4.5.0-beta",
diff --git a/register.js b/register.js
index c6f41b0e..7d681960 100755
--- a/register.js
+++ b/register.js
@@ -7,5 +7,4 @@ try {
   );
 }
 
-tsNode.register();
 require('./').nodeRegister();
diff --git a/src/compatibility/node-register.ts b/src/compatibility/node-register.ts
index cba3369e..74799c84 100755
--- a/src/compatibility/node-register.ts
+++ b/src/compatibility/node-register.ts
@@ -68,7 +68,7 @@ export function mergeTransformers(
 // region: TsNode Registration Utility
 /* ****************************************************************************************************************** */
 
-export function nodeRegister(): TSNode.RegisterOptions | undefined {
+export function nodeRegister(): TSNode.Service | undefined {
   const { tsNodeInstance, tsNode } = nodeRegister.initialize();
 
   const transformerConfig = getProjectTransformerConfig(tsNodeInstance.config);
@@ -96,8 +96,7 @@ export function nodeRegister(): TSNode.RegisterOptions | undefined {
   }
 
   // Re-register with new transformers
-  tsNode.register(registerOptions);
-  return registerOptions;
+  return tsNode.register(registerOptions);
 }
 
 export namespace nodeRegister {
diff --git a/test/projects/esm-loader/package.json b/test/projects/esm-loader/package.json
new file mode 100755
index 00000000..cc8fd44c
--- /dev/null
+++ b/test/projects/esm-loader/package.json
@@ -0,0 +1,6 @@
+{
+  "private": true,
+  "name": "@tests/esm-loader",
+  "version": "0.0.0",
+  "type": "module"
+}
diff --git a/test/projects/esm-loader/src/id.ts b/test/projects/esm-loader/src/id.ts
new file mode 100755
index 00000000..01b2dc8e
--- /dev/null
+++ b/test/projects/esm-loader/src/id.ts
@@ -0,0 +1 @@
+export const b = null;
diff --git a/test/projects/esm-loader/src/index.ts b/test/projects/esm-loader/src/index.ts
new file mode 100755
index 00000000..c0bb14c0
--- /dev/null
+++ b/test/projects/esm-loader/src/index.ts
@@ -0,0 +1,4 @@
+export * from "#identifier";
+import { b } from "#identifier";
+
+console.log(b);
diff --git a/test/projects/esm-loader/tsconfig.json b/test/projects/esm-loader/tsconfig.json
new file mode 100755
index 00000000..49a3c232
--- /dev/null
+++ b/test/projects/esm-loader/tsconfig.json
@@ -0,0 +1,29 @@
+{
+  "include": [ "src" ],
+
+  "compilerOptions": {
+    "noEmit": true,
+
+    "rootDir": ".",
+    "module": "ESNext",
+    "target": "ESNext",
+    "esModuleInterop": true,
+    "moduleResolution": "node",
+    "declaration": true,
+
+    "baseUrl": "./src",
+    "paths": {
+      "#identifier": [ "./id.ts" ]
+    },
+
+    "plugins": [
+      {
+        "transform": "typescript-transform-paths"
+      },
+      {
+        "transform": "typescript-transform-paths",
+        "afterDeclarations": true
+      }
+    ]
+  }
+}
diff --git a/test/tests/compatibility/esm-loader.test.ts b/test/tests/compatibility/esm-loader.test.ts
new file mode 100755
index 00000000..8641c1a9
--- /dev/null
+++ b/test/tests/compatibility/esm-loader.test.ts
@@ -0,0 +1,22 @@
+import { execSync } from "child_process";
+import path from "path";
+import ts from 'typescript'
+import { projectsPath } from "../../src/config";
+
+/* ****************************************************************************************************************** *
+ * Tests
+ * ****************************************************************************************************************** */
+
+describe(`ESM Loader`, () => {
+  const esmProjectRoot = ts.normalizePath(path.join(projectsPath, "esm-loader"));
+
+  // See: https://github.com/LeDDGroup/typescript-transform-paths/issues/134
+  test(`Transforms ESM project`, () => {
+    const res = execSync(
+      `node --no-warnings --loader tstp/esm --es-module-specifier-resolution=node src/index.ts`,
+      { cwd: esmProjectRoot }
+    ).toString();
+
+    expect(res).toMatch(/^null($|\r?\n)/);
+  });
+});
diff --git a/test/tests/compatibility/node-register.test.ts b/test/tests/compatibility/node-register.test.ts
index 59dd17b5..7f3d7cf5 100755
--- a/test/tests/compatibility/node-register.test.ts
+++ b/test/tests/compatibility/node-register.test.ts
@@ -60,6 +60,7 @@ describe(`[Compatibility: ts-node] Register script`, () => {
         registerSpy?.mockRestore();
       }
     });
+
     test(`Uses existing ts-node if found`, () => {
       const fakeInstance: any = {};
 
@@ -172,7 +173,7 @@ describe(`[Compatibility: ts-node] Register script`, () => {
           });
 
           const originalTsNodeInstance = global.process[instanceSymbol];
-          registerResult = nodeRegister()!;
+          registerResult = nodeRegister()!.options;
           instanceRegistrationResult = global.process[instanceSymbol]!;
           global.process[instanceSymbol] = originalTsNodeInstance;
 
diff --git a/yarn.lock b/yarn.lock
index 6f98ae26..06dfd1d7 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -482,6 +482,18 @@
   resolved "https://registry.yarnpkg.com/@bcoe/v8-coverage/-/v8-coverage-0.2.3.tgz#75a2e8b51cb758a7553d6804a5932d7aace75c39"
   integrity sha512-0hYQ8SB4Db5zvZB4axdMHGwEaQjkZzFjQiN9LVYvIFB2nSUHW9tYpxWriPrWDASIxiaXax83REcLxuSdnGPZtw==
 
+"@cspotcode/source-map-consumer@0.8.0":
+  version "0.8.0"
+  resolved "https://registry.yarnpkg.com/@cspotcode/source-map-consumer/-/source-map-consumer-0.8.0.tgz#33bf4b7b39c178821606f669bbc447a6a629786b"
+  integrity sha512-41qniHzTU8yAGbCp04ohlmSrZf8bkf/iJsl3V0dRGsQN/5GFfx+LbCSsCpp2gqrqjTVg/K6O8ycoV35JIwAzAg==
+
+"@cspotcode/source-map-support@0.7.0":
+  version "0.7.0"
+  resolved "https://registry.yarnpkg.com/@cspotcode/source-map-support/-/source-map-support-0.7.0.tgz#4789840aa859e46d2f3173727ab707c66bf344f5"
+  integrity sha512-X4xqRHqN8ACt2aHVe51OxeA2HjbcL4MqFqXkrmQszJ1NOUuUu5u6Vqx/0lZSVNku7velL5FC/s5uEAj1lsBMhA==
+  dependencies:
+    "@cspotcode/source-map-consumer" "0.8.0"
+
 "@hutson/parse-repository-url@^3.0.0":
   version "3.0.2"
   resolved "https://registry.yarnpkg.com/@hutson/parse-repository-url/-/parse-repository-url-3.0.2.tgz#98c23c950a3d9b6c8f0daed06da6c3af06981340"
@@ -717,7 +729,7 @@
   resolved "https://registry.yarnpkg.com/@tsconfig/node14/-/node14-1.0.1.tgz#95f2d167ffb9b8d2068b0b235302fafd4df711f2"
   integrity sha512-509r2+yARFfHHE7T6Puu2jjkoycftovhXRqW328PDXTVGKihlb1P8Z9mMZH04ebyajfRY7dedfGynlrFHJUQCg==
 
-"@tsconfig/node16@^1.0.1":
+"@tsconfig/node16@^1.0.2":
   version "1.0.2"
   resolved "https://registry.yarnpkg.com/@tsconfig/node16/-/node16-1.0.2.tgz#423c77877d0569db20e1fc80885ac4118314010e"
   integrity sha512-eZxlbI8GZscaGS7kkc/trHTT5xgrjH3/1n2JDwusC9iahPKWMRvRjJSAN5mCXviuTGQ/lHnhvv8Q1YTpnfz9gA==
@@ -876,6 +888,11 @@ acorn-walk@^7.1.1:
   resolved "https://registry.yarnpkg.com/acorn-walk/-/acorn-walk-7.2.0.tgz#0de889a601203909b0fbe07b8938dc21d2e967bc"
   integrity sha512-OPdCF6GsMIP+Az+aWfAAOEt2/+iVDKE7oy6lJ098aoe59oAmK76qV6Gw60SbZ8jHuG2wH058GF4pLFbYamYrVA==
 
+acorn-walk@^8.1.1:
+  version "8.2.0"
+  resolved "https://registry.yarnpkg.com/acorn-walk/-/acorn-walk-8.2.0.tgz#741210f2e2426454508853a2f44d0ab83b7f69c1"
+  integrity sha512-k+iyHEuPgSw6SbuDpGQM+06HQUa04DZ3o+F6CSzXMvvI5KMvnaEqXe+YVe555R9nn6GPt404fos4wcgpw12SDA==
+
 acorn@^7.1.1:
   version "7.4.1"
   resolved "https://registry.yarnpkg.com/acorn/-/acorn-7.4.1.tgz#feaed255973d2e77555b83dbc08851a6c63520fa"
@@ -886,6 +903,11 @@ acorn@^8.2.4:
   resolved "https://registry.yarnpkg.com/acorn/-/acorn-8.4.1.tgz#56c36251fc7cabc7096adc18f05afe814321a28c"
   integrity sha512-asabaBSkEKosYKMITunzX177CXxQ4Q8BSSzMTKD+FefUhipQC70gfW5SiUDhYQ3vk8G+81HqQk7Fv9OXwwn9KA==
 
+acorn@^8.4.1:
+  version "8.5.0"
+  resolved "https://registry.yarnpkg.com/acorn/-/acorn-8.5.0.tgz#4512ccb99b3698c752591e9bb4472e38ad43cee2"
+  integrity sha512-yXbYeFy+jUuYd3/CDcg2NkIYE991XYX/bje7LmjJigUciaeO1JR4XxXgCIV1/Zc/dRuFEyw1L0pbA+qynJkW5Q==
+
 add-stream@^1.0.0:
   version "1.0.0"
   resolved "https://registry.yarnpkg.com/add-stream/-/add-stream-1.0.0.tgz#6a7990437ca736d5e1288db92bd3266d5f5cb2aa"
@@ -3357,7 +3379,7 @@ slash@^3.0.0:
   resolved "https://registry.yarnpkg.com/slash/-/slash-3.0.0.tgz#6539be870c165adbd5240220dbe361f1bc4d4634"
   integrity sha512-g9Q1haeby36OSStwb4ntCGGGaKsaVSjQ68fBxoQcutl5fS1vuY18H3wSt3jFyFtrkx+Kz0V1G85A4MyAdDMi2Q==
 
-source-map-support@^0.5.17, source-map-support@^0.5.6:
+source-map-support@^0.5.6:
   version "0.5.19"
   resolved "https://registry.yarnpkg.com/source-map-support/-/source-map-support-0.5.19.tgz#a98b62f86dcaf4f67399648c085291ab9e8fed61"
   integrity sha512-Wonm7zOCIJzBGQdB+thsPar0kYuCIzYvxZwlBa87yi/Mdjv7Tip2cyVbLj5o0cFPN4EVkuTwb3GDDyUx2DGnGw==
@@ -3665,20 +3687,22 @@ ts-jest@^27.0.4:
     semver "7.x"
     yargs-parser "20.x"
 
-ts-node@^10.1.0:
-  version "10.1.0"
-  resolved "https://registry.yarnpkg.com/ts-node/-/ts-node-10.1.0.tgz#e656d8ad3b61106938a867f69c39a8ba6efc966e"
-  integrity sha512-6szn3+J9WyG2hE+5W8e0ruZrzyk1uFLYye6IGMBadnOzDh8aP7t8CbFpsfCiEx2+wMixAhjFt7lOZC4+l+WbEA==
+ts-node@^10.4.0:
+  version "10.4.0"
+  resolved "https://registry.yarnpkg.com/ts-node/-/ts-node-10.4.0.tgz#680f88945885f4e6cf450e7f0d6223dd404895f7"
+  integrity sha512-g0FlPvvCXSIO1JDF6S232P5jPYqBkRL9qly81ZgAOSU7rwI0stphCgd2kLiCrU9DjQCrJMWEqcNSjQL02s6d8A==
   dependencies:
+    "@cspotcode/source-map-support" "0.7.0"
     "@tsconfig/node10" "^1.0.7"
     "@tsconfig/node12" "^1.0.7"
     "@tsconfig/node14" "^1.0.0"
-    "@tsconfig/node16" "^1.0.1"
+    "@tsconfig/node16" "^1.0.2"
+    acorn "^8.4.1"
+    acorn-walk "^8.1.1"
     arg "^4.1.0"
     create-require "^1.1.0"
     diff "^4.0.1"
     make-error "^1.1.1"
-    source-map-support "^0.5.17"
     yn "3.1.1"
 
 ts-patch@^1.4.4: