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Line 1 CRC IP MS

Data are available via ProteomeXchange with identifier PXD013743.
contact [email protected] for any questions
06/06/2019

We had 10 groups as follow:

Site of Tumor Condition Tumor Diagnosis IHC staining source Version
Ovary Igg A Krukenberg Carcinoma Very very strong L1 expresse 1
Ovary Normal A Krukenberg Carcinoma Very very strong L1 expresse 1
Ovary Igg A Krukenberg Carcinoma Very very strong L1 expresse 2
Ovary Normal A Krukenberg Carcinoma Very very strong L1 expresse 2
Liver Igg B Metastatic Rectal Adenocarcinoma Strong 3/3 in liver and node 1
Liver Normal B Metastatic Rectal Adenocarcinoma Strong 3/3 in liver and node 1
Liver Tumor B Metastatic Rectal Adenocarcinoma Strong 3/3 in liver and node 1
Colon Igg C Adenocarcinoma 2/3 expression 1
Colon Normal C Adenocarcinoma 2/3 expression 1
Colon Tumor C Adenocarcinoma 2/3 expression 1

Project code and data is organized in following order:

Project Pipeline:

Pipeline

QC:

Imputation:

Comparison before - after imputation:

Pipeline
Pipeline
Pipeline

Average intensities before - after imputation:

Average intensities before imputation Average intensities after imputation

ANOVA result:

Venndiagram

VennDiagram of significant proteins

Volcano plots and mutations

comparison between Tumor C (colon) against ORF1 and IgG

Volcano plot compare Colon Tumor tissue to Igg

comparison between Tumor C (colon) and normal tissue against ORF1

Volcano plot compare Colon Tumor tissue to Normal

comparison between Tumor B (liver) against ORF1 and IgG

Volcano plot compare Liver Tumor tissue to Igg

Mutated peptides in significant ORF1 loci in tumor B against ORF1 and IgG

Observed significant Liver colon tissue against ORF1 and IgG

Mutation frequency in tumor B against ORF1 and IgG

Mutation frequency in liver tumor against ORF1 and IgG

comparison between Tumor B (liver) and normal tissue against ORF1

Volcano plot compare Liver Tumor tissue to Normal

Mutated peptides in significant ORF1 loci in Tumor B and normal tissue against ORF1

Observed significant Liver Tumor tissue and normal tissue against ORF1

Mutation frequency in tumor B and normal tissue against ORF1

Mutation frequency in liver tumor and normal tissue against ORF1

comparison between Tumor A (ovary) against ORF1 and IgG - phase 1

Volcano plot compare Ovary Tumor tissue to Igg - phase1

Mutated peptides in significant ORF1 loci in Tumor A against ORF1 and IgG - phase1

Observed significant Ovary Tumor tissue against ORF1 and IgG - phase1

Mutation frequency in tumor A against ORF1 and IgG

Mutation frequency in Ovary tumor against ORF1 and IgG

comparison between Tumor A (ovary) against ORF1 and IgG - phase 2

Volcano plot compare Ovary Tumor tissue to Igg - phase2

Mutated peptides in significant ORF1 loci in Tumor A tissue against ORF1 and IgG - phase2

Observed significant Ovary Tumor tissue against ORF1 and IgG - phase2

Mutation frequency in tumor A and normal tissue against ORF1

Mutation frequency in Ovary tumor and normal tissue against ORF1

Integrated plot:

Venndiagram:

VenDiagram of expressed proteins

MDS plot:

MDS plot

Polar map of proteins that were significant in two conditions or were observed in previous researches and were significant in at least one condition:

Polar map - comparison of Colon significant proteins in different tissue

Heat map of all significant proteins across different tissues:

Heatmap - all significant proteins