diff --git a/pkgs/development/python-modules/theano-pymc/default.nix b/pkgs/development/python-modules/theano-pymc/default.nix
deleted file mode 100644
index 31c08585e0064..0000000000000
--- a/pkgs/development/python-modules/theano-pymc/default.nix
+++ /dev/null
@@ -1,51 +0,0 @@
-{
-  lib,
-  fetchPypi,
-  buildPythonPackage,
-  pythonOlder,
-  pandas,
-  numpy,
-  scipy,
-  filelock,
-  pytest,
-  nose,
-  parameterized,
-}:
-
-buildPythonPackage rec {
-  pname = "theano-pymc";
-  version = "1.1.2";
-  format = "setuptools";
-  disabled = pythonOlder "3.6";
-
-  src = fetchPypi {
-    pname = "Theano-PyMC";
-    inherit version;
-    sha256 = "5da6c2242ea72a991c8446d7fe7d35189ea346ef7d024c890397011114bf10fc";
-  };
-
-  # No need for coverage stats in Nix builds
-  postPatch = ''
-    substituteInPlace setup.py --replace ", 'pytest-cov'" ""
-  '';
-
-  propagatedBuildInputs = [
-    pandas
-    numpy
-    scipy
-    filelock
-  ];
-
-  # The test suite is computationally intensive and test failures are not
-  # indicative for package usability hence tests are disabled by default.
-  doCheck = false;
-  pythonImportsCheck = [ "theano" ];
-
-  meta = {
-    description = "PyMC theano fork";
-    homepage = "https://github.com/majidaldo/Theano-PyMC";
-    license = lib.licenses.asl20;
-    maintainers = with lib.maintainers; [ nidabdella ];
-    broken = true;
-  };
-}
diff --git a/pkgs/development/python-modules/theano/default.nix b/pkgs/development/python-modules/theano/default.nix
deleted file mode 100644
index 8d10dc61a9a18..0000000000000
--- a/pkgs/development/python-modules/theano/default.nix
+++ /dev/null
@@ -1,117 +0,0 @@
-{
-  lib,
-  stdenv,
-  runCommandCC,
-  fetchPypi,
-  buildPythonPackage,
-  isPyPy,
-  pythonOlder,
-  isPy3k,
-  nose,
-  numpy,
-  scipy,
-  setuptools,
-  six,
-  libgpuarray,
-  config,
-  cudaSupport ? config.cudaSupport,
-  cudaPackages ? { },
-  cudnnSupport ? cudaSupport,
-}:
-
-let
-  inherit (cudaPackages) cudatoolkit cudnn;
-in
-
-assert cudnnSupport -> cudaSupport;
-
-let
-  wrapped =
-    command: buildTop: buildInputs:
-    runCommandCC "${command}-wrapped" { inherit buildInputs; } ''
-      type -P '${command}' || { echo '${command}: not found'; exit 1; }
-      cat > "$out" <<EOF
-      #!$(type -P bash)
-      $(declare -xp | sed -e '/^[^=]\+="\('"''${NIX_STORE//\//\\/}"'\|[^\/]\)/!d')
-      declare -x NIX_BUILD_TOP="${buildTop}"
-      $(type -P '${command}') "\$@"
-      EOF
-      chmod +x "$out"
-    '';
-
-  # Theano spews warnings and disabled flags if the compiler isn't named g++
-  cxx_compiler_name =
-    if stdenv.cc.isGNU then
-      "g++"
-    else if stdenv.cc.isClang then
-      "clang++"
-    else
-      throw "Unknown C++ compiler";
-  cxx_compiler = wrapped cxx_compiler_name "\\$HOME/.theano" (
-    lib.optional cudaSupport libgpuarray_ ++ lib.optional cudnnSupport cudnn
-  );
-
-  # We need to be careful with overriding Python packages within the package set
-  # as this can lead to collisions!
-  libgpuarray_ = libgpuarray.override { inherit cudaSupport cudaPackages; };
-in
-buildPythonPackage rec {
-  pname = "theano";
-  version = "1.0.5";
-  format = "setuptools";
-
-  disabled = isPyPy || pythonOlder "2.6";
-
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "129f43ww2a6badfdr6b88kzjzz2b0wk0dwkvwb55z6dsagfkk53f";
-  };
-
-  postPatch =
-    ''
-      substituteInPlace theano/configdefaults.py \
-        --replace 'StrParam(param, is_valid=warn_cxx)' 'StrParam('\'''${cxx_compiler}'\''', is_valid=warn_cxx)' \
-        --replace 'rc == 0 and config.cxx != ""' 'config.cxx != ""'
-    ''
-    + lib.optionalString cudaSupport ''
-      substituteInPlace theano/configdefaults.py \
-        --replace 'StrParam(get_cuda_root)' 'StrParam('\'''${cudatoolkit}'\''')'
-    ''
-    + lib.optionalString cudnnSupport ''
-      substituteInPlace theano/configdefaults.py \
-        --replace 'StrParam(default_dnn_base_path)' 'StrParam('\'''${cudnn}'\''')'
-    '';
-
-  # needs to be postFixup so it runs before pythonImportsCheck even when
-  # doCheck = false (meaning preCheck would be disabled)
-  postFixup = ''
-    mkdir -p check-phase
-    export HOME=$(pwd)/check-phase
-  '';
-  doCheck = false;
-  # takes far too long, also throws "TypeError: sort() missing 1 required positional argument: 'a'"
-  # when run from the installer, and testing with Python 3.5 hits github.com/Theano/Theano/issues/4276,
-  # the fix for which hasn't been merged yet.
-
-  # keep Nose around since running the tests by hand is possible from Python or bash
-  nativeCheckInputs = [ nose ];
-  # setuptools needed for cuda support
-  propagatedBuildInputs = [
-    libgpuarray_
-    numpy
-    numpy.blas
-    scipy
-    setuptools
-    six
-  ];
-
-  pythonImportsCheck = [ "theano" ];
-
-  meta = with lib; {
-    homepage = "https://github.com/Theano/Theano";
-    description = "A Python library for large-scale array computation";
-    license = licenses.bsd3;
-    maintainers = [ ];
-    broken = true;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 9d18dc422d505..96475aa4fa7fe 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -531,6 +531,10 @@ mapAliases ({
   Theano = theano; # added 2023-02-19
   TheanoWithCuda = theanoWithCuda; # added 2023-02-19
   TheanoWithoutCuda = theanoWithoutCuda; # added 2023-02-19
+  theano = throw "theano has been removed because it is no longer maintained"; # added 2024-05-20
+  theanoWithCuda = throw "theano has been removed because it is no longer maintained"; # added 2024-05-20
+  theanoWithoutCuda = throw "theano has been removed because it is no longer maintained"; # added 2024-05-20
+  theano-pymc = throw "theano-pymc has been removed because it is no longer maintained"; # added 2024-05-20
   thumborPexif = throw "thumborPexif has been removed, because it was unused."; # added 2024-01-07
   torchgpipe = throw "torchgpipe has been removed, because it appears unmaintained and Pytorch now includes pipeline parallelism support"; # added 2024-05-18
   torrent_parser = torrent-parser; # added 2023-11-04
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 8989a790739b6..5b076211e63c3 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -15105,23 +15105,6 @@ self: super: with self; {
 
   tgcrypto = callPackage ../development/python-modules/tgcrypto { };
 
-  theano-pymc = callPackage ../development/python-modules/theano-pymc { };
-
-  theano = callPackage ../development/python-modules/theano rec {
-    inherit (pkgs.config) cudaSupport;
-    cudnnSupport = cudaSupport;
-  };
-
-  theanoWithCuda = self.theano.override {
-    cudaSupport = true;
-    cudnnSupport = true;
-  };
-
-  theanoWithoutCuda = self.theano.override {
-    cudaSupport = false;
-    cudnnSupport = false;
-  };
-
   thefuzz = callPackage ../development/python-modules/thefuzz { };
 
   thelogrus = callPackage ../development/python-modules/thelogrus { };