diff --git a/pkgs/applications/terminal-emulators/wezterm/default.nix b/pkgs/applications/terminal-emulators/wezterm/default.nix
index 00117185c5564..e00f8ede1e05d 100644
--- a/pkgs/applications/terminal-emulators/wezterm/default.nix
+++ b/pkgs/applications/terminal-emulators/wezterm/default.nix
@@ -20,15 +20,10 @@
   xcbutilwm,
   wayland,
   zlib,
-  CoreGraphics,
-  Cocoa,
-  Foundation,
-  System,
-  libiconv,
-  UserNotifications,
   nixosTests,
   runCommand,
   vulkan-loader,
+  fetchpatch2,
 }:
 
 rustPlatform.buildRustPackage rec {
@@ -43,6 +38,21 @@ rustPlatform.buildRustPackage rec {
     hash = "sha256-Az+HlnK/lRJpUSGm5UKyma1l2PaBKNCGFiaYnLECMX8=";
   };
 
+  patches = [
+    # Remove unused `fdopen` in vendored zlib, which causes compilation failures with clang 19 on Darwin.
+    # Ref: https://github.com/madler/zlib/commit/4bd9a71f3539b5ce47f0c67ab5e01f3196dc8ef9
+    ./zlib-fdopen.patch
+
+    # Fix platform check in vendored libpng with clang 19 on Darwin.
+    (fetchpatch2 {
+      url = "https://github.com/pnggroup/libpng/commit/893b8113f04d408cc6177c6de19c9889a48faa24.patch?full_index=1";
+      extraPrefix = "deps/freetype/libpng/";
+      stripLen = 1;
+      excludes = [ "deps/freetype/libpng/AUTHORS" ];
+      hash = "sha256-zW/oUo2EGcnsxAfbbbhTKGui/lwCqovyrvUnylfRQzc=";
+    })
+  ];
+
   postPatch = ''
     cp ${./Cargo.lock} Cargo.lock
 
@@ -88,20 +98,10 @@ rustPlatform.buildRustPackage rec {
       xcbutilimage
       xcbutilkeysyms
       xcbutilwm # contains xcb-ewmh among others
-    ]
-    ++ lib.optionals stdenv.hostPlatform.isDarwin [
-      Cocoa
-      CoreGraphics
-      Foundation
-      libiconv
-      System
-      UserNotifications
     ];
 
   buildFeatures = [ "distro-defaults" ];
 
-  env.NIX_LDFLAGS = lib.optionalString stdenv.hostPlatform.isDarwin "-framework System";
-
   postInstall = ''
     mkdir -p $out/nix-support
     echo "${passthru.terminfo}" >> $out/nix-support/propagated-user-env-packages
diff --git a/pkgs/applications/terminal-emulators/wezterm/zlib-fdopen.patch b/pkgs/applications/terminal-emulators/wezterm/zlib-fdopen.patch
new file mode 100644
index 0000000000000..c4f78035e01d9
--- /dev/null
+++ b/pkgs/applications/terminal-emulators/wezterm/zlib-fdopen.patch
@@ -0,0 +1,24 @@
+Submodule deps/freetype/zlib contains modified content
+diff --git a/deps/freetype/zlib/zutil.h b/deps/freetype/zlib/zutil.h
+index b079ea6..4e94f2f 100644
+--- a/deps/freetype/zlib/zutil.h
++++ b/deps/freetype/zlib/zutil.h
+@@ -130,17 +130,8 @@ extern z_const char * const z_errmsg[10]; /* indexed by 2-zlib_error */
+ #  endif
+ #endif
+ 
+-#if defined(MACOS) || defined(TARGET_OS_MAC)
++#if defined(MACOS)
+ #  define OS_CODE  7
+-#  ifndef Z_SOLO
+-#    if defined(__MWERKS__) && __dest_os != __be_os && __dest_os != __win32_os
+-#      include <unix.h> /* for fdopen */
+-#    else
+-#      ifndef fdopen
+-#        define fdopen(fd,mode) NULL /* No fdopen() */
+-#      endif
+-#    endif
+-#  endif
+ #endif
+ 
+ #ifdef __acorn
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index f0eee07bcfdfe..67fcd849be8f0 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -1583,9 +1583,7 @@ with pkgs;
   };
   termite-unwrapped = callPackage ../applications/terminal-emulators/termite { };
 
-  wezterm = darwin.apple_sdk_11_0.callPackage ../applications/terminal-emulators/wezterm {
-    inherit (darwin.apple_sdk_11_0.frameworks) Cocoa CoreGraphics Foundation UserNotifications System;
-  };
+  wezterm = callPackage ../applications/terminal-emulators/wezterm { };
 
   twine = with python3Packages; toPythonApplication twine;