diff --git a/pkgs/development/python-modules/paddleocr/default.nix b/pkgs/development/python-modules/paddleocr/default.nix
index 8033d8c79e6df..fe2ad63e0e6ba 100644
--- a/pkgs/development/python-modules/paddleocr/default.nix
+++ b/pkgs/development/python-modules/paddleocr/default.nix
@@ -14,7 +14,6 @@
   openpyxl,
   pdf2docx,
   pillow,
-  premailer,
   pyclipper,
   pymupdf,
   python-docx,
@@ -76,7 +75,6 @@ buildPythonPackage {
     openpyxl
     pdf2docx
     pillow
-    premailer
     pyclipper
     pymupdf
     python-docx
diff --git a/pkgs/development/python-modules/premailer/default.nix b/pkgs/development/python-modules/premailer/default.nix
deleted file mode 100644
index dd6eec493338a..0000000000000
--- a/pkgs/development/python-modules/premailer/default.nix
+++ /dev/null
@@ -1,43 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchPypi,
-  isPy27,
-  cssselect,
-  cssutils,
-  lxml,
-  mock,
-  nose,
-  requests,
-  cachetools,
-}:
-
-buildPythonPackage rec {
-  pname = "premailer";
-  version = "3.10.0";
-  format = "setuptools";
-  disabled = isPy27; # no longer compatible with urllib
-
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "d1875a8411f5dc92b53ef9f193db6c0f879dc378d618e0ad292723e388bfe4c2";
-  };
-
-  buildInputs = [
-    mock
-    nose
-  ];
-  propagatedBuildInputs = [
-    cachetools
-    cssselect
-    cssutils
-    lxml
-    requests
-  ];
-
-  meta = {
-    description = "Turns CSS blocks into style attributes";
-    homepage = "https://github.com/peterbe/premailer";
-    license = lib.licenses.bsd3;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index d590c94b5cdfd..e9bee1b0cd4c4 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -407,6 +407,7 @@ mapAliases ({
   postorius = throw "Please use pkgs.mailmanPackages.postorius"; # added 2022-04-29
   powerlineMemSegment = powerline-mem-segment; # added 2021-10-08
   prayer-times-calculator = prayer-times-calculator-offline; # added 2024-08-11
+  premailer = throw "premailer was removed, as it is not compatible with lxml>4.9.4.";
   privacyidea-ldap-proxy = throw "privacyidea-ldap-proxy has been removed from nixpkgs"; # added 2023-10-31
   proboscis = throw "proboscis has been removed since it has not been maintained for 11 years"; # added 2024-05-20
   prometheus_client = prometheus-client; # added 2021-06-10
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b0d9ca65a2fe6..59acc25ce6949 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -10650,8 +10650,6 @@ self: super: with self; {
 
   preggy = callPackage ../development/python-modules/preggy { };
 
-  premailer = callPackage ../development/python-modules/premailer { };
-
   preprocess-cancellation = callPackage ../development/python-modules/preprocess-cancellation { };
 
   preshed = callPackage ../development/python-modules/preshed { };