diff --git a/pkgs/servers/matrix-synapse/default.nix b/pkgs/servers/matrix-synapse/default.nix
index db9ba29a0c828..0335af7ab50ba 100644
--- a/pkgs/servers/matrix-synapse/default.nix
+++ b/pkgs/servers/matrix-synapse/default.nix
@@ -10,7 +10,6 @@
   rustc,
   nixosTests,
   callPackage,
-  fetchpatch2,
 }:
 
 let
@@ -19,31 +18,22 @@ let
 in
 python3.pkgs.buildPythonApplication rec {
   pname = "matrix-synapse";
-  version = "1.121.1";
+  version = "1.122.0";
   format = "pyproject";
 
   src = fetchFromGitHub {
     owner = "element-hq";
     repo = "synapse";
     rev = "v${version}";
-    hash = "sha256-0sLzngo6jBpKyqgw8XwgPzpmSWR7pjXT58XcDJCUq0s=";
+    hash = "sha256-pucGVKEjQNihlHmFxhgJSiX7sxpQYrCpSwhZByBtbe8=";
   };
 
   cargoDeps = rustPlatform.fetchCargoTarball {
     inherit src;
     name = "${pname}-${version}";
-    hash = "sha256-LGFuz3NtNqH+XumJOirvflH0fyfTtqz5qgYlJx2fmAU=";
+    hash = "sha256-AZi3QIPHqfxfCGcZAAD0rzmzLH6tUxhuq+Tc38qdUKc=";
   };
 
-  patches = [
-    # Fixes test compat with twisted 24.11.0.
-    # Can be removed in next release.
-    (fetchpatch2 {
-      url = "https://github.com/element-hq/synapse/commit/3eb92369ca14012a07da2fbf9250e66f66afb710.patch";
-      sha256 = "sha256-VDn3kQy23+QC2WKhWfe0FrUOnLuI1YwH5GxdTTVWt+A=";
-    })
-  ];
-
   postPatch = ''
     # Remove setuptools_rust from runtime dependencies
     # https://github.com/element-hq/synapse/blob/v1.69.0/pyproject.toml#L177-L185