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TranceptEVE indel scoring doesn't like end-of-sequence insertions #37

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carolc24 opened this issue Jul 14, 2024 · 0 comments
Open

TranceptEVE indel scoring doesn't like end-of-sequence insertions #37

carolc24 opened this issue Jul 14, 2024 · 0 comments

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@carolc24
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I've been trying to score a library of sequences, one of which has an extra amino acid at the end of the sequence. Every time I get an error:

Error when processing the following alignment: /pub/cannistc/liu/DMS_msa_files/Sampled/Expanded_a320f19e-5573-4c7d-b48c-c94b3579bacb_TranceptEVE_7699654675_psald_benchmark.a2m

Error when processing the following alignment: /pub/cannistc/liu/DMS_msa_files/Sampled/Expanded_a10e0443-4bdb-4886-834b-024f58845f30_TranceptEVE_5425001349_psald_benchmark.a2m

Error when adding zero column(s) to account for insertion mutations.

I've been trying to modify the relevant code in msa_utils.py to handle adding zero columns to the MSA log prior, but nothing has worked so far. For now I might just throw out that sequence, but does anyone have thoughts on how to fix this?

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