diff --git a/app/src/App/OnDeviceDisplayApp.tsx b/app/src/App/OnDeviceDisplayApp.tsx
index 1459ff5071f8..1439fc9de2c1 100644
--- a/app/src/App/OnDeviceDisplayApp.tsx
+++ b/app/src/App/OnDeviceDisplayApp.tsx
@@ -20,6 +20,7 @@ import { OnDeviceLocalizationProvider } from '../LocalizationProvider'
 import { ToasterOven } from '../organisms/ToasterOven'
 import { MaintenanceRunTakeover } from '../organisms/TakeoverModal'
 import { FirmwareUpdateTakeover } from '../organisms/FirmwareUpdateModal/FirmwareUpdateTakeover'
+import { IncompatibleModuleTakeover } from '../organisms/IncompatibleModuleModal/IncompatibleModuleTakeover'
 import { EstopTakeover } from '../organisms/EmergencyStop'
 import { ConnectViaEthernet } from '../pages/ConnectViaEthernet'
 import { ConnectViaUSB } from '../pages/ConnectViaUSB'
@@ -179,6 +180,7 @@ export const OnDeviceDisplayApp = (): JSX.Element => {
               ) : (
                 <>
                   <EstopTakeover />
+                  <IncompatibleModuleTakeover />
                   <MaintenanceRunTakeover>
                     <FirmwareUpdateTakeover />
                     <NiceModal.Provider>
diff --git a/app/src/assets/localization/en/incompatible_modules.json b/app/src/assets/localization/en/incompatible_modules.json
new file mode 100644
index 000000000000..547ac5eba587
--- /dev/null
+++ b/app/src/assets/localization/en/incompatible_modules.json
@@ -0,0 +1,4 @@
+{
+  "incompatible_modules_attached": "incompatible module detected",
+  "remove_before_running_protocol": "Remove the following hardware before running a protocol:"
+}
diff --git a/app/src/assets/localization/en/index.ts b/app/src/assets/localization/en/index.ts
index 51acf92db530..aef6c301f3ee 100644
--- a/app/src/assets/localization/en/index.ts
+++ b/app/src/assets/localization/en/index.ts
@@ -27,6 +27,7 @@ import robot_controls from './robot_controls.json'
 import run_details from './run_details.json'
 import top_navigation from './top_navigation.json'
 import error_recovery from './error_recovery.json'
+import incompatible_modules from './incompatible_modules.json'
 
 export const en = {
   shared,
@@ -58,4 +59,5 @@ export const en = {
   run_details,
   top_navigation,
   error_recovery,
+  incompatible_modules,
 }
diff --git a/app/src/organisms/IncompatibleModuleModal/IncompatibleModuleModalBody.tsx b/app/src/organisms/IncompatibleModuleModal/IncompatibleModuleModalBody.tsx
new file mode 100644
index 000000000000..353abb7256e2
--- /dev/null
+++ b/app/src/organisms/IncompatibleModuleModal/IncompatibleModuleModalBody.tsx
@@ -0,0 +1,51 @@
+import * as React from 'react'
+import { useTranslation, Trans } from 'react-i18next'
+import capitalize from 'lodash/capitalize'
+import {
+  DIRECTION_COLUMN,
+  Flex,
+  SPACING,
+  StyledText,
+TYPOGRAPHY,
+    OVERFLOW_SCROLL,
+
+} from '@opentrons/components'
+import {
+    getModuleDisplayName
+} from '@opentrons/shared-data'
+import type { AttachedModule } from '@opentrons/api-client'
+import { Modal } from '../../molecules/Modal'
+import { ListItem } from '../../atoms/ListItem'
+import type { ModalHeaderBaseProps } from '../../molecules/Modal/types'
+
+export interface IncompatibleModuleModalBodyProps {
+  modules: AttachedModule[]
+}
+
+export function IncompatibleModuleModalBody(
+  props: IncompatibleModuleModalBodyProps
+): JSX.Element {
+  const { t } = useTranslation('incompatible_modules')
+  const incompatibleModuleHeader: ModalHeaderBaseProps = {
+    title: capitalize(t('incompatible_modules_attached')),
+  }
+  const { modules } = props
+  return (
+      <Modal header={incompatibleModuleHeader}>
+          <Flex flexDirection={DIRECTION_COLUMN} width="100%">
+              <StyledText as="p" marginBottom={SPACING.spacing32} >
+                  <Trans t={t} i18nKey="remove_before_running_protocol" />
+              </StyledText>
+              <Flex overflowY={OVERFLOW_SCROLL} flexDirection={DIRECTION_COLUMN} gridGap={SPACING.spacing8} maxHeight='196px'>
+                  {...modules.map(module => (
+                      <ListItem key={module.id} type="noActive">
+                          <StyledText as="p" key={module.id} fontWeight={TYPOGRAPHY.fontWeightSemiBold}>
+                              {getModuleDisplayName(module.moduleModel)}
+                          </StyledText>
+                      </ListItem>
+                  ))}
+              </Flex>
+          </Flex>
+      </Modal>
+  )
+}
diff --git a/app/src/organisms/IncompatibleModuleModal/IncompatibleModuleTakeover.tsx b/app/src/organisms/IncompatibleModuleModal/IncompatibleModuleTakeover.tsx
new file mode 100644
index 000000000000..7faecaaa3d61
--- /dev/null
+++ b/app/src/organisms/IncompatibleModuleModal/IncompatibleModuleTakeover.tsx
@@ -0,0 +1,25 @@
+import * as React from 'react'
+import { createPortal } from 'react-dom'
+import { useTranslation, Trans } from 'react-i18next'
+import capitalize from 'lodash/capitalize'
+import { IncompatibleModuleModalBody } from './IncompatibleModuleModalBody'
+import { getTopPortalEl } from '../../App/portal'
+import { useIncompatibleModulesAttached } from './hooks'
+
+const POLL_INTERVAL_MS = 5000
+
+export function IncompatibleModuleTakeover(): JSX.Element {
+  const incompatibleModules = useIncompatibleModulesAttached({
+    refetchInterval: POLL_INTERVAL_MS,
+  })
+  return (
+    <>
+      {incompatibleModules.length !== 0
+        ? createPortal(
+            <IncompatibleModuleModalBody modules={incompatibleModules} />,
+            getTopPortalEl()
+          )
+        : null}
+    </>
+  )
+}
diff --git a/app/src/organisms/IncompatibleModuleModal/hooks/__fixtures__/incompatibleModuleFixtures.ts b/app/src/organisms/IncompatibleModuleModal/hooks/__fixtures__/incompatibleModuleFixtures.ts
new file mode 100644
index 000000000000..fbe7141b4cee
--- /dev/null
+++ b/app/src/organisms/IncompatibleModuleModal/hooks/__fixtures__/incompatibleModuleFixtures.ts
@@ -0,0 +1,386 @@
+export const mockModulesAllNotImplementedResponse = [
+  {
+    id: '3feb840a3fa2dac2409b977f1e330f54f50e6231',
+    serialNumber: 'dummySerialTC',
+    firmwareVersion: 'dummyVersionTC',
+    hardwareRevision: 'dummyModelTC',
+    hasAvailableUpdate: false,
+    moduleType: 'thermocyclerModuleType',
+    moduleModel: 'thermocyclerModuleV1',
+    data: {
+      status: 'holding at target',
+      currentTemperature: 3.0,
+      targetTemperature: 3.0,
+      lidStatus: 'open',
+      lidTemperature: 4.0,
+      lidTargetTemperature: 4.0,
+      holdTime: 121.0,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+  {
+    id: '8bcc37fdfcb4c2b5ab69963c589ceb1f9b1d1c4f',
+    serialNumber: 'dummySerialHS',
+    firmwareVersion: 'dummyVersionHS',
+    hardwareRevision: 'dummyModelHS',
+    hasAvailableUpdate: false,
+    moduleType: 'heaterShakerModuleType',
+    moduleModel: 'heaterShakerModuleV1',
+    data: {
+      status: 'idle',
+      labwareLatchStatus: 'idle_unknown',
+      speedStatus: 'idle',
+      currentSpeed: 0,
+      temperatureStatus: 'idle',
+      currentTemperature: 23.0,
+      targetSpeed: null,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+  {
+    id: '5fe40b412e39c6c079125b5dd4820ad8044e0962',
+    serialNumber: 'dummySerialTD',
+    firmwareVersion: 'dummyVersionTD',
+    hardwareRevision: 'temp_deck_v1.1',
+    hasAvailableUpdate: false,
+    moduleType: 'temperatureModuleType',
+    moduleModel: 'temperatureModuleV1',
+    data: {
+      status: 'holding at target',
+      currentTemperature: 3.0,
+      targetTemperature: 3.0,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+  {
+    id: '67a5b5118a952417b4aa47a62a96deccb13bed32',
+    serialNumber: 'dummySerialMD',
+    firmwareVersion: 'dummyVersionMD',
+    hardwareRevision: 'mag_deck_v1.1',
+    hasAvailableUpdate: false,
+    moduleType: 'magneticModuleType',
+    moduleModel: 'magneticModuleV1',
+    data: {
+      status: 'engaged',
+      engaged: true,
+      height: 4.0,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+]
+
+export const mockModulesAllCompatibleResponse = [
+  {
+    id: '3feb840a3fa2dac2409b977f1e330f54f50e6231',
+    serialNumber: 'dummySerialTC',
+    firmwareVersion: 'dummyVersionTC',
+    hardwareRevision: 'dummyModelTC',
+    hasAvailableUpdate: false,
+    moduleType: 'thermocyclerModuleType',
+    moduleModel: 'thermocyclerModuleV1',
+    compatibleWithRobot: true,
+    data: {
+      status: 'holding at target',
+      currentTemperature: 3.0,
+      targetTemperature: 3.0,
+      lidStatus: 'open',
+      lidTemperature: 4.0,
+      lidTargetTemperature: 4.0,
+      holdTime: 121.0,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+  {
+    id: '8bcc37fdfcb4c2b5ab69963c589ceb1f9b1d1c4f',
+    serialNumber: 'dummySerialHS',
+    firmwareVersion: 'dummyVersionHS',
+    hardwareRevision: 'dummyModelHS',
+    hasAvailableUpdate: false,
+    moduleType: 'heaterShakerModuleType',
+    moduleModel: 'heaterShakerModuleV1',
+    compatibleWithRobot: true,
+    data: {
+      status: 'idle',
+      labwareLatchStatus: 'idle_unknown',
+      speedStatus: 'idle',
+      currentSpeed: 0,
+      temperatureStatus: 'idle',
+      currentTemperature: 23.0,
+      targetSpeed: null,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+  {
+    id: '5fe40b412e39c6c079125b5dd4820ad8044e0962',
+    serialNumber: 'dummySerialTD',
+    firmwareVersion: 'dummyVersionTD',
+    hardwareRevision: 'temp_deck_v1.1',
+    hasAvailableUpdate: false,
+    moduleType: 'temperatureModuleType',
+    moduleModel: 'temperatureModuleV1',
+    compatibleWithRobot: true,
+    data: {
+      status: 'holding at target',
+      currentTemperature: 3.0,
+      targetTemperature: 3.0,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+  {
+    id: '67a5b5118a952417b4aa47a62a96deccb13bed32',
+    serialNumber: 'dummySerialMD',
+    firmwareVersion: 'dummyVersionMD',
+    hardwareRevision: 'mag_deck_v1.1',
+    hasAvailableUpdate: false,
+    moduleType: 'magneticModuleType',
+    moduleModel: 'magneticModuleV1',
+    compatibleWithRobot: true,
+    data: {
+      status: 'engaged',
+      engaged: true,
+      height: 4.0,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+]
+
+export const mockModulesWithOneIncompatibleResponse = [
+  {
+    id: '3feb840a3fa2dac2409b977f1e330f54f50e6231',
+    serialNumber: 'dummySerialTC',
+    firmwareVersion: 'dummyVersionTC',
+    hardwareRevision: 'dummyModelTC',
+    hasAvailableUpdate: false,
+    moduleType: 'thermocyclerModuleType',
+    moduleModel: 'thermocyclerModuleV1',
+    compatibleWithRobot: false,
+    data: {
+      status: 'holding at target',
+      currentTemperature: 3.0,
+      targetTemperature: 3.0,
+      lidStatus: 'open',
+      lidTemperature: 4.0,
+      lidTargetTemperature: 4.0,
+      holdTime: 121.0,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+  {
+    id: '8bcc37fdfcb4c2b5ab69963c589ceb1f9b1d1c4f',
+    serialNumber: 'dummySerialHS',
+    firmwareVersion: 'dummyVersionHS',
+    hardwareRevision: 'dummyModelHS',
+    hasAvailableUpdate: false,
+    moduleType: 'heaterShakerModuleType',
+    moduleModel: 'heaterShakerModuleV1',
+    compatibleWithRobot: true,
+    data: {
+      status: 'idle',
+      labwareLatchStatus: 'idle_unknown',
+      speedStatus: 'idle',
+      currentSpeed: 0,
+      temperatureStatus: 'idle',
+      currentTemperature: 23.0,
+      targetSpeed: null,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+  {
+    id: '5fe40b412e39c6c079125b5dd4820ad8044e0962',
+    serialNumber: 'dummySerialTD',
+    firmwareVersion: 'dummyVersionTD',
+    hardwareRevision: 'temp_deck_v1.1',
+    hasAvailableUpdate: false,
+    moduleType: 'temperatureModuleType',
+    moduleModel: 'temperatureModuleV1',
+    compatibleWithRobot: true,
+    data: {
+      status: 'holding at target',
+      currentTemperature: 3.0,
+      targetTemperature: 3.0,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+  {
+    id: '67a5b5118a952417b4aa47a62a96deccb13bed32',
+    serialNumber: 'dummySerialMD',
+    firmwareVersion: 'dummyVersionMD',
+    hardwareRevision: 'mag_deck_v1.1',
+    hasAvailableUpdate: false,
+    moduleType: 'magneticModuleType',
+    moduleModel: 'magneticModuleV1',
+    compatibleWithRobot: true,
+    data: {
+      status: 'engaged',
+      engaged: true,
+      height: 4.0,
+    },
+    usbPort: {
+      port: 0,
+      path: '',
+      hub: false,
+      portGroup: 'unknown',
+    },
+  },
+]
+
+export const v2MockModulesResponse = [
+  {
+    name: 'thermocycler',
+    displayName: 'thermocycler',
+    moduleModel: 'thermocyclerModuleV1',
+    port: '/dev/ot_module_sim_thermocycler0',
+    usbPort: {
+      port: 0,
+      hub: false,
+      portGroup: 'unknown',
+      path: '',
+    },
+    serial: 'dummySerialTC',
+    model: 'dummyModelTC',
+    revision: 'dummyModelTC',
+    fwVersion: 'dummyVersionTC',
+    hasAvailableUpdate: false,
+    status: 'holding at target',
+    data: {
+      lid: 'open',
+      lidTarget: 4.0,
+      lidTemp: 4.0,
+      currentTemp: 3.0,
+      targetTemp: 3.0,
+      holdTime: 121.0,
+      rampRate: null,
+      currentCycleIndex: null,
+      totalCycleCount: null,
+      currentStepIndex: null,
+      totalStepCount: null,
+    },
+  },
+  {
+    name: 'heatershaker',
+    displayName: 'heatershaker',
+    moduleModel: 'heaterShakerModuleV1',
+    port: '/dev/ot_module_sim_heatershaker1',
+    usbPort: {
+      hub: false,
+      portGroup: 'unknown',
+      path: '',
+      port: 0,
+    },
+    serial: 'dummySerialHS',
+    model: 'dummyModelHS',
+    revision: 'dummyModelHS',
+    fwVersion: 'dummyVersionHS',
+    hasAvailableUpdate: false,
+    status: 'idle',
+    data: {
+      labwareLatchStatus: 'idle_unknown',
+      speedStatus: 'idle',
+      temperatureStatus: 'idle',
+      currentSpeed: 0,
+      currentTemp: 23.0,
+      targetSpeed: null,
+      targetTemp: null,
+      errorDetails: null,
+    },
+  },
+  {
+    name: 'tempdeck',
+    displayName: 'tempdeck',
+    moduleModel: 'temperatureModuleV1',
+    port: '/dev/ot_module_sim_tempdeck2',
+    usbPort: {
+      hub: false,
+      portGroup: 'unknown',
+      path: '',
+      port: 0,
+    },
+    serial: 'dummySerialTD',
+    model: 'temp_deck_v1.1',
+    revision: 'temp_deck_v1.1',
+    fwVersion: 'dummyVersionTD',
+    hasAvailableUpdate: false,
+    status: 'holding at target',
+    data: {
+      currentTemp: 3.0,
+      targetTemp: 3.0,
+    },
+  },
+  {
+    name: 'magdeck',
+    displayName: 'magdeck',
+    moduleModel: 'magneticModuleV1',
+    port: '/dev/ot_module_sim_magdeck3',
+    usbPort: {
+      port: 0,
+      hub: false,
+      portGroup: 'unknown',
+      path: '',
+    },
+    serial: 'dummySerialMD',
+    model: 'mag_deck_v1.1',
+    revision: 'mag_deck_v1.1',
+    fwVersion: 'dummyVersionMD',
+    hasAvailableUpdate: false,
+    status: 'engaged',
+    data: {
+      engaged: true,
+      height: 4.0,
+    },
+  },
+]
diff --git a/app/src/organisms/IncompatibleModuleModal/hooks/__fixtures__/index.ts b/app/src/organisms/IncompatibleModuleModal/hooks/__fixtures__/index.ts
new file mode 100644
index 000000000000..fc83332dba79
--- /dev/null
+++ b/app/src/organisms/IncompatibleModuleModal/hooks/__fixtures__/index.ts
@@ -0,0 +1 @@
+export * from './incompatibleModuleFixtures'
diff --git a/app/src/organisms/IncompatibleModuleModal/hooks/__tests__/useIncompatibleModulesAttached.test.tsx b/app/src/organisms/IncompatibleModuleModal/hooks/__tests__/useIncompatibleModulesAttached.test.tsx
new file mode 100644
index 000000000000..f4c641c2a08e
--- /dev/null
+++ b/app/src/organisms/IncompatibleModuleModal/hooks/__tests__/useIncompatibleModulesAttached.test.tsx
@@ -0,0 +1,58 @@
+import * as React from 'react'
+import { QueryClient, QueryClientProvider } from 'react-query'
+
+import { vi, it, expect, describe, beforeEach } from 'vitest'
+import { renderHook } from '@testing-library/react'
+import { useModulesQuery } from '@opentrons/react-api-client'
+import { useIncompatibleModulesAttached } from '..'
+
+import * as Fixtures from '../__fixtures__'
+
+import type { HostConfig, Response, Modules } from '@opentrons/api-client'
+vi.mock('@opentrons/react-api-client')
+
+describe('useIncompatibleModulesAttached', () => {
+  let wrapper: React.FunctionComponent<
+    { children: React.ReactNode } & HostConfig
+  >
+  beforeEach(() => {
+    const queryClient = new QueryClient()
+    const clientProvider: React.FunctionComponent<{
+      children: React.ReactNode
+    }> = ({ children }) => (
+      <QueryClientProvider client={queryClient}>{children}</QueryClientProvider>
+    )
+    wrapper = clientProvider
+  })
+  it('treats older endpoint responses as if the module were compatible', () => {
+    vi.mocked(useModulesQuery).mockReturnValue({
+      data: Fixtures.v2MockModulesResponse,
+    } as Response<Modules>)
+    const { result } = renderHook(useIncompatibleModulesAttached, { wrapper })
+    expect(result.current).toHaveLength(0)
+  })
+  it('pulls incompatible modules out of endpoint responses', () => {
+    vi.mocked(useModulesQuery).mockReturnValue({
+      data: Fixtures.mockModulesWithOneIncompatibleResponse,
+    } as Response<Modules>)
+    const { result } = renderHook(useIncompatibleModulesAttached, { wrapper })
+    expect(result.current).toHaveLength(1)
+    expect(result.current).toContain(
+      Fixtures.mockModulesWithOneIncompatibleResponse[0]
+    )
+  })
+  it('treats modules under new schema without compatibility as compatible', () => {
+    vi.mocked(useModulesQuery).mockReturnValue({
+      data: Fixtures.mockModulesAllNotImplementedResponse,
+    } as Response<Modules>)
+    const { result } = renderHook(useIncompatibleModulesAttached, { wrapper })
+    expect(result.current).toHaveLength(0)
+  })
+  it('passes all compatible modules', () => {
+    vi.mocked(useModulesQuery).mockReturnValue({
+      data: Fixtures.mockModulesAllCompatibleResponse,
+    } as Response<Modules>)
+    const { result } = renderHook(useIncompatibleModulesAttached, { wrapper })
+    expect(result.current).toHaveLength(0)
+  })
+})
diff --git a/app/src/organisms/IncompatibleModuleModal/hooks/index.ts b/app/src/organisms/IncompatibleModuleModal/hooks/index.ts
new file mode 100644
index 000000000000..9a5e19787476
--- /dev/null
+++ b/app/src/organisms/IncompatibleModuleModal/hooks/index.ts
@@ -0,0 +1 @@
+export * from './useIncompatibleModulesAttached'
diff --git a/app/src/organisms/IncompatibleModuleModal/hooks/useIncompatibleModulesAttached.ts b/app/src/organisms/IncompatibleModuleModal/hooks/useIncompatibleModulesAttached.ts
new file mode 100644
index 000000000000..9fc0105aed0f
--- /dev/null
+++ b/app/src/organisms/IncompatibleModuleModal/hooks/useIncompatibleModulesAttached.ts
@@ -0,0 +1,15 @@
+import { useModulesQuery } from '@opentrons/react-api-client'
+import type { UseQueryOptions } from 'react-query'
+import type { AttachedModule, Modules, HostConfig } from '@opentrons/api-client'
+
+export function useIncompatibleModulesAttached(
+  options: UseQueryOptions<Modules> = {},
+  hostOverride?: HostConfig | null
+): AttachedModule[] {
+  const attachedModulesResponse = useModulesQuery({ ...options })
+  return (
+    attachedModulesResponse.data?.data?.filter(
+      attachedModule => attachedModule?.compatibleWithRobot === false
+    ) || []
+  )
+}
diff --git a/app/src/organisms/IncompatibleModuleModal/index.tsx b/app/src/organisms/IncompatibleModuleModal/index.tsx
new file mode 100644
index 000000000000..e9866b2689cc
--- /dev/null
+++ b/app/src/organisms/IncompatibleModuleModal/index.tsx
@@ -0,0 +1 @@
+export * from './IncompatibleModuleTakeover'