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PoN created with more samples ended up smaller PoN #692

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sainadfensi opened this issue Feb 12, 2025 · 0 comments
Open

PoN created with more samples ended up smaller PoN #692

sainadfensi opened this issue Feb 12, 2025 · 0 comments

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@sainadfensi
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sainadfensi commented Feb 12, 2025 •
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Dear developer of GRIDSS,

Thank you developing GRIDSS for structural variant identification and keeping it updated for years. We tried making a PoN bedpe using our own blood samples two times with different numbers of samples. However, having more samples for the PoN leads to much less record in the PoN (half the number), which is a bit counterintuitive to us. It looks like the PoN built from less samples are actually more stringent?
@sainadfensi sainadfensi changed the title PoN created with more samples but ended up less PoN SVs PoN created with more samples ended up smaller PoN Feb 12, 2025
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