diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/ABCG2_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/ABCG2_translation.json
index 7051ba93..c623ee15 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/ABCG2_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/ABCG2_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2023-02-03T16:20:52.044Z",
"gene": "ABCG2",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CACNA1S_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CACNA1S_translation.json
index 1af6bbca..c6e857b3 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CACNA1S_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CACNA1S_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2021-10-22T20:00:04.974Z",
"gene": "CACNA1S",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CFTR_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CFTR_translation.json
index 8bae5374..f09ec215 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CFTR_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CFTR_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2021-10-22T20:11:12.866Z",
"gene": "CFTR",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2B6_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2B6_translation.json
index 21da40c4..16be6728 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2B6_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2B6_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2023-10-01T23:08:56.987Z",
"gene": "CYP2B6",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2C19_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2C19_translation.json
index 95db5fe8..c95eb0d9 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2C19_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2C19_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2022-10-04T01:59:42.269Z",
"gene": "CYP2C19",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2C9_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2C9_translation.json
index 01612908..83d348da 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2C9_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2C9_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2022-05-04T17:44:46.640Z",
"gene": "CYP2C9",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2D6_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2D6_translation.json
index 0c3d5987..4286317d 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2D6_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP2D6_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2024-07-09T23:28:22.310Z",
"gene": "CYP2D6",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP3A4_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP3A4_translation.json
index 5fab348d..52f2e186 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP3A4_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP3A4_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2023-10-01T23:03:51.828Z",
"gene": "CYP3A4",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP3A5_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP3A5_translation.json
index 23823bb0..b8cb7ab3 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP3A5_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP3A5_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2022-02-18T18:47:52.807Z",
"gene": "CYP3A5",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP4F2_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP4F2_translation.json
index 05fff49d..07f4262c 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP4F2_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/CYP4F2_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2024-01-31T01:10:40.916Z",
"gene": "CYP4F2",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/DPYD_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/DPYD_translation.json
index 5ef615bd..cdcc0870 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/DPYD_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/DPYD_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2024-07-09T22:17:49.647Z",
"gene": "DPYD",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/G6PD_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/G6PD_translation.json
index 1a0b2330..46f5f4f5 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/G6PD_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/G6PD_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2023-09-26T20:24:28.185Z",
"gene": "G6PD",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/IFNL3_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/IFNL3_translation.json
index 4f294982..6409a57b 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/IFNL3_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/IFNL3_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2023-06-27T18:23:26Z",
"gene": "IFNL3",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/NUDT15_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/NUDT15_translation.json
index d0234f0a..d4a8db3b 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/NUDT15_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/NUDT15_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2021-10-22T19:44:45.760Z",
"gene": "NUDT15",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/RYR1_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/RYR1_translation.json
index 7a341c68..a1a6f263 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/RYR1_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/RYR1_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2023-12-19T17:19:46.010Z",
"gene": "RYR1",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/SLCO1B1_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/SLCO1B1_translation.json
index ef6416ee..d5d42f3f 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/SLCO1B1_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/SLCO1B1_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2021-12-02T22:52:37.860Z",
"gene": "SLCO1B1",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/TPMT_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/TPMT_translation.json
index e167ab16..d543a227 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/TPMT_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/TPMT_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2021-10-14T03:54:49.779Z",
"gene": "TPMT",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/UGT1A1_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/UGT1A1_translation.json
index dc630951..c3951f58 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/UGT1A1_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/UGT1A1_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2023-06-29T22:31:18.415Z",
"gene": "UGT1A1",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/VKORC1_translation.json b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/VKORC1_translation.json
index 98a265ac..57958c33 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/VKORC1_translation.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/definition/alleles/VKORC1_translation.json
@@ -1,7 +1,7 @@
{
"formatVersion": "2",
"source": "PHARMGKB",
- "version": "2024-07-25-21-55",
+ "version": "2024-07-30-09-20",
"modificationDate": "2023-05-04T00:25:05.851Z",
"gene": "VKORC1",
"orientation": null,
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/ABCG2.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/ABCG2.json
index e1f296d0..f16df7e9 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/ABCG2.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/ABCG2.json
@@ -55,5 +55,5 @@
"lookupKey": "Decreased function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CACNA1S.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CACNA1S.json
index afb678e8..40894587 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CACNA1S.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CACNA1S.json
@@ -97,5 +97,5 @@
"lookupKey": "Malignant Hyperthermia associated"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CFTR.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CFTR.json
index 429ff11d..387f245f 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CFTR.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CFTR.json
@@ -10087,5 +10087,5 @@
"lookupKey": "ivacaftor non-responsive"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2B6.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2B6.json
index 04c68202..5f67471b 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2B6.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2B6.json
@@ -14407,5 +14407,5 @@
"lookupKey": "Uncertain function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2C19.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2C19.json
index 0845cd78..4024a313 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2C19.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2C19.json
@@ -8215,5 +8215,5 @@
"lookupKey": "Uncertain function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2C9.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2C9.json
index 3940dadd..88029496 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2C9.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2C9.json
@@ -34733,5 +34733,5 @@
"lookupKey": "n/a"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2D6.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2D6.json
index 1b5b40af..409bdf6c 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2D6.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP2D6.json
@@ -38,7 +38,7 @@
"*25": "n/a",
"*26": "n/a",
"*27": "1.0",
- "*27x2": "2",
+ "*27x2": "2.0",
"*28": "n/a",
"*28x2": "n/a",
"*29": "0.5",
@@ -213,7 +213,7 @@
"*25": "n/a",
"*26": "n/a",
"*27": "1.0",
- "*27x2": "2",
+ "*27x2": "2.0",
"*28": "n/a",
"*28x2": "n/a",
"*29": "0.5",
@@ -794,6 +794,18 @@
"activityScore": "2.0",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*1/*27x2",
+ "description": null,
+ "lookupkey": "3.0",
+ "diplotypekey": {
+ "*1": 1,
+ "*27x2": 1
+ },
+ "activityScore": "3.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*1/*28",
@@ -2845,6 +2857,18 @@
"activityScore": "3.0",
"phenotype": "Ultrarapid Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*1x2/*27x2",
+ "description": null,
+ "lookupkey": "4.0",
+ "diplotypekey": {
+ "*1x2": 1,
+ "*27x2": 1
+ },
+ "activityScore": "4.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*1x2/*28",
@@ -4884,6 +4908,18 @@
"activityScore": "≥4.0",
"phenotype": "Ultrarapid Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*1x≥3/*27x2",
+ "description": null,
+ "lookupkey": "≥5.0",
+ "diplotypekey": {
+ "*1x≥3": 1,
+ "*27x2": 1
+ },
+ "activityScore": "≥5.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*1x≥3/*28",
@@ -6911,6 +6947,18 @@
"activityScore": "2.0",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*2/*27x2",
+ "description": null,
+ "lookupkey": "3.0",
+ "diplotypekey": {
+ "*2": 1,
+ "*27x2": 1
+ },
+ "activityScore": "3.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*2/*28",
@@ -8926,6 +8974,18 @@
"activityScore": "3.0",
"phenotype": "Ultrarapid Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*2x2/*27x2",
+ "description": null,
+ "lookupkey": "4.0",
+ "diplotypekey": {
+ "*2x2": 1,
+ "*27x2": 1
+ },
+ "activityScore": "4.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*2x2/*28",
@@ -10929,6 +10989,18 @@
"activityScore": "≥4.0",
"phenotype": "Ultrarapid Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*2x≥3/*27x2",
+ "description": null,
+ "lookupkey": "≥5.0",
+ "diplotypekey": {
+ "*2x≥3": 1,
+ "*27x2": 1
+ },
+ "activityScore": "≥5.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*2x≥3/*28",
@@ -12920,6 +12992,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*3/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*3": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*3/*28",
@@ -14899,6 +14983,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*3x2/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*3x2": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*3x2/*28",
@@ -16866,6 +16962,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*4/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*4": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*4/*28",
@@ -18821,6 +18929,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*4x2/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*4x2": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*4x2/*28",
@@ -20764,6 +20884,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*4x≥3/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*4x≥3": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*4x≥3/*28",
@@ -22695,6 +22827,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*5/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*5": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*5/*28",
@@ -24614,6 +24758,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*6/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*6": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*6/*28",
@@ -26521,6 +26677,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*6x2/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*6x2": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*6x2/*28",
@@ -28416,6 +28584,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*7/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*7": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*7/*28",
@@ -30299,6 +30479,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*8/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*8": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*8/*28",
@@ -32170,6 +32362,18 @@
"activityScore": "1.25",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*9/*27x2",
+ "description": null,
+ "lookupkey": "2.25",
+ "diplotypekey": {
+ "*9": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.25",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*9/*28",
@@ -34029,6 +34233,18 @@
"activityScore": "1.5",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*9x2/*27x2",
+ "description": null,
+ "lookupkey": "2.5",
+ "diplotypekey": {
+ "*9x2": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.5",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*9x2/*28",
@@ -35876,6 +36092,18 @@
"activityScore": "1.25",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*10/*27x2",
+ "description": null,
+ "lookupkey": "2.25",
+ "diplotypekey": {
+ "*10": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.25",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*10/*28",
@@ -37711,6 +37939,18 @@
"activityScore": "1.5",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*10x2/*27x2",
+ "description": null,
+ "lookupkey": "2.5",
+ "diplotypekey": {
+ "*10x2": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.5",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*10x2/*28",
@@ -39534,6 +39774,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*11/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*11": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*11/*28",
@@ -41345,6 +41597,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*12/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*12": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*12/*28",
@@ -43144,6 +43408,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*13/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*13": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*13/*28",
@@ -44931,6 +45207,18 @@
"activityScore": "1.5",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*14/*27x2",
+ "description": null,
+ "lookupkey": "2.5",
+ "diplotypekey": {
+ "*14": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.5",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*14/*28",
@@ -46706,6 +46994,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*15/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*15": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*15/*28",
@@ -48469,6 +48769,18 @@
"activityScore": "1.5",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*17/*27x2",
+ "description": null,
+ "lookupkey": "2.5",
+ "diplotypekey": {
+ "*17": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.5",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*17/*28",
@@ -50220,6 +50532,18 @@
"activityScore": "2.0",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*17x2/*27x2",
+ "description": null,
+ "lookupkey": "3.0",
+ "diplotypekey": {
+ "*17x2": 1,
+ "*27x2": 1
+ },
+ "activityScore": "3.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*17x2/*28",
@@ -51959,6 +52283,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*18/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*18": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*18/*28",
@@ -53686,6 +54022,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*19/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*19": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*19/*28",
@@ -55401,6 +55749,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*20/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*20": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*20/*28",
@@ -57104,6 +57464,18 @@
"activityScore": "1.0",
"phenotype": "Intermediate Metabolizer"
},
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*21/*27x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*21": 1,
+ "*27x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*21/*28",
@@ -58795,6 +59167,18 @@
"activityScore": "n/a",
"phenotype": "Indeterminate"
},
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*22/*27x2",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*22": 1,
+ "*27x2": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*22/*28",
@@ -60474,6 +60858,18 @@
"activityScore": "n/a",
"phenotype": "Indeterminate"
},
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*23/*27x2",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*23": 1,
+ "*27x2": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*23/*28",
@@ -62141,6 +62537,18 @@
"activityScore": "n/a",
"phenotype": "Indeterminate"
},
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*24/*27x2",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*24": 1,
+ "*27x2": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*24/*28",
@@ -63796,6 +64204,18 @@
"activityScore": "n/a",
"phenotype": "Indeterminate"
},
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*25/*27x2",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*25": 1,
+ "*27x2": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*25/*28",
@@ -65439,6 +65859,18 @@
"activityScore": "n/a",
"phenotype": "Indeterminate"
},
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*26/*27x2",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*26": 1,
+ "*27x2": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*26/*28",
@@ -67070,6 +67502,18 @@
"activityScore": "2.0",
"phenotype": "Normal Metabolizer"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27/*27x2",
+ "description": null,
+ "lookupkey": "3.0",
+ "diplotypekey": {
+ "*27": 1,
+ "*27x2": 1
+ },
+ "activityScore": "3.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*27/*28",
@@ -68690,6 +69134,1637 @@
"activityScore": "n/a",
"phenotype": "Indeterminate"
},
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*27x2",
+ "description": null,
+ "lookupkey": "4.0",
+ "diplotypekey": {
+ "*27x2": 2
+ },
+ "activityScore": "4.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*28",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*28": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*28x2",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*28x2": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*29",
+ "description": null,
+ "lookupkey": "2.5",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*29": 1
+ },
+ "activityScore": "2.5",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*29x2",
+ "description": null,
+ "lookupkey": "3.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*29x2": 1
+ },
+ "activityScore": "3.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*30",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*30": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*31",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*31": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*32",
+ "description": null,
+ "lookupkey": "2.25",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*32": 1
+ },
+ "activityScore": "2.25",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*33",
+ "description": null,
+ "lookupkey": "3.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*33": 1
+ },
+ "activityScore": "3.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*34",
+ "description": null,
+ "lookupkey": "3.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*34": 1
+ },
+ "activityScore": "3.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*35",
+ "description": null,
+ "lookupkey": "3.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*35": 1
+ },
+ "activityScore": "3.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*35x2",
+ "description": null,
+ "lookupkey": "4.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*35x2": 1
+ },
+ "activityScore": "4.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*36",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*36": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*36x2",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*36x2": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*37",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*37": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*38",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*38": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*39",
+ "description": null,
+ "lookupkey": "3.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*39": 1
+ },
+ "activityScore": "3.0",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*40",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*40": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*41",
+ "description": null,
+ "lookupkey": "2.25",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*41": 1
+ },
+ "activityScore": "2.25",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*41x2",
+ "description": null,
+ "lookupkey": "2.5",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*41x2": 1
+ },
+ "activityScore": "2.5",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Ultrarapid Metabolizer",
+ "diplotype": "*27x2/*41x3",
+ "description": null,
+ "lookupkey": "2.75",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*41x3": 1
+ },
+ "activityScore": "2.75",
+ "phenotype": "Ultrarapid Metabolizer"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*42",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*42": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*43",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*43": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*43x2",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*43x2": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*44",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*44": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
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+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*125",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*125": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*126",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*126": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*127",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*127": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*128",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*128": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*129",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*129": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*130",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*130": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*131",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*131": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*132",
+ "description": null,
+ "lookupkey": "2.25",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*132": 1
+ },
+ "activityScore": "2.25",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*133",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*133": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*134",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*134": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*135",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*135": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*136",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*136": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*137",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*137": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*138",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*138": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*139",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*139": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*140",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*140": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*141",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*141": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*142",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*142": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*143",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*143": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*144",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*144": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*145",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*145": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*146",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*146": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*146x2",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*146x2": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*147",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*147": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*148",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*148": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*149",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*149": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*152",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*152": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*153",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*153": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*154",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*154": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*155",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*155": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*156",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*156": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*157",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*157": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*158",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*158": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*159",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*159": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*160",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*160": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Normal Metabolizer",
+ "diplotype": "*27x2/*161",
+ "description": null,
+ "lookupkey": "2.0",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*161": 1
+ },
+ "activityScore": "2.0",
+ "phenotype": "Normal Metabolizer"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*162",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*162": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
+ {
+ "generesult": "Indeterminate",
+ "diplotype": "*27x2/*163",
+ "description": null,
+ "lookupkey": "n/a",
+ "diplotypekey": {
+ "*27x2": 1,
+ "*163": 1
+ },
+ "activityScore": "n/a",
+ "phenotype": "Indeterminate"
+ },
{
"generesult": "Indeterminate",
"diplotype": "*28/*28",
@@ -178941,9 +181016,9 @@
},
{
"name": "*27x2",
- "activityValue": "2",
+ "activityValue": "2.0",
"functionValue": "Increased function",
- "lookupKey": "2"
+ "lookupKey": "2.0"
},
{
"name": "*28",
@@ -179756,5 +181831,5 @@
"lookupKey": "n/a"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP3A5.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP3A5.json
index 670a287b..68c93c4e 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP3A5.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/CYP3A5.json
@@ -295,5 +295,5 @@
"lookupKey": "Unknown function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/DPYD.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/DPYD.json
index 0fcfb6c4..90d75425 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/DPYD.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/DPYD.json
@@ -43436,5 +43436,5 @@
"lookupKey": "1.0"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/G6PD.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/G6PD.json
index ba778219..68678e4d 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/G6PD.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/G6PD.json
@@ -214122,5 +214122,5 @@
"lookupKey": "Uncertain function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/IFNL3.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/IFNL3.json
index d184af7a..5727f680 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/IFNL3.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/IFNL3.json
@@ -20,5 +20,5 @@
"lookupKey": "Unfavorable response allele"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/MT_RNR1.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/MT_RNR1.json
index 9c0edabd..fef6f1d5 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/MT_RNR1.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/MT_RNR1.json
@@ -457,5 +457,5 @@
"lookupKey": "Uncertain risk of aminoglycoside-induced hearing loss"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/NUDT15.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/NUDT15.json
index 3768b73c..122ce5d9 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/NUDT15.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/NUDT15.json
@@ -601,5 +601,5 @@
"lookupKey": "No function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/RYR1.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/RYR1.json
index 12ab9229..599cda15 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/RYR1.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/RYR1.json
@@ -697687,5 +697687,5 @@
"lookupKey": "Uncertain function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/SLCO1B1.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/SLCO1B1.json
index 56dca61e..d01279f4 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/SLCO1B1.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/SLCO1B1.json
@@ -12151,5 +12151,5 @@
"lookupKey": "No function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/TPMT.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/TPMT.json
index c39c8c7a..62c254e7 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/TPMT.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/TPMT.json
@@ -11617,5 +11617,5 @@
"lookupKey": "No function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/UGT1A1.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/UGT1A1.json
index 67860a8b..db2381d2 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/UGT1A1.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/cpic/UGT1A1.json
@@ -601,5 +601,5 @@
"lookupKey": "Decreased function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/ABCG2.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/ABCG2.json
index e1f296d0..f16df7e9 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/ABCG2.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/ABCG2.json
@@ -55,5 +55,5 @@
"lookupKey": "Decreased function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2B6.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2B6.json
index 49a89830..c68ca851 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2B6.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2B6.json
@@ -217,5 +217,5 @@
"lookupKey": "No function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2C19.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2C19.json
index 0ad6466a..ef9dda2d 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2C19.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2C19.json
@@ -865,5 +865,5 @@
"lookupKey": "Increased function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2C9.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2C9.json
index ffadba4d..dfc8449e 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2C9.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2C9.json
@@ -727,5 +727,5 @@
"lookupKey": "Decreased function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2D6.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2D6.json
index 7a041d93..eaf1160a 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2D6.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP2D6.json
@@ -12743,5 +12743,5 @@
"lookupKey": "0.0"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP3A4.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP3A4.json
index cb1a64b0..1d2fa960 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP3A4.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP3A4.json
@@ -1015,5 +1015,5 @@
"lookupKey": "No function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP3A5.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP3A5.json
index 5db1c6c1..6714896d 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP3A5.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/CYP3A5.json
@@ -151,5 +151,5 @@
"lookupKey": "No function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/DPYD.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/DPYD.json
index 208b41be..b5480949 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/DPYD.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/DPYD.json
@@ -302,5 +302,5 @@
"lookupKey": "0.5"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/NUDT15.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/NUDT15.json
index 5bbf6e98..6ec7ab41 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/NUDT15.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/NUDT15.json
@@ -601,5 +601,5 @@
"lookupKey": "Decreased function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/SLCO1B1.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/SLCO1B1.json
index f18b59a3..c9065d37 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/SLCO1B1.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/SLCO1B1.json
@@ -295,5 +295,5 @@
"lookupKey": "Decreased function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/TPMT.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/TPMT.json
index e8bc7d91..0cc6aad9 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/TPMT.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/TPMT.json
@@ -2647,5 +2647,5 @@
"lookupKey": "No function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/UGT1A1.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/UGT1A1.json
index 26436151..c83a9882 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/UGT1A1.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/UGT1A1.json
@@ -487,5 +487,5 @@
"lookupKey": "Decreased function"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/VKORC1.json b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/VKORC1.json
index 8047eb8d..ea3ba6e2 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/VKORC1.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/phenotype/dpwg/VKORC1.json
@@ -55,5 +55,5 @@
"lookupKey": "Higher coumarin sensitivity"
}
],
- "version": "2024-07-25-21-55"
+ "version": "2024-07-30-09-20"
}
\ No newline at end of file
diff --git a/src/main/resources/org/pharmgkb/pharmcat/reporter/prescribing_guidance.json b/src/main/resources/org/pharmgkb/pharmcat/reporter/prescribing_guidance.json
index 77239be2..4342aa15 100644
--- a/src/main/resources/org/pharmgkb/pharmcat/reporter/prescribing_guidance.json
+++ b/src/main/resources/org/pharmgkb/pharmcat/reporter/prescribing_guidance.json
@@ -94231,6 +94231,116 @@
],
"url": "https://www.pharmgkb.org/labelAnnotation/PA166104891"
},
+ {
+ "guideline": {
+ "id": "PA166104903",
+ "name": "Annotation of FDA Label for nitrofurantoin and G6PD",
+ "objCls": "Label Annotation",
+ "source": "FDA",
+ "version": 31,
+ "url": null,
+ "relatedChemicals": [
+ {
+ "id": "PA450640",
+ "name": "nitrofurantoin",
+ "symbol": null
+ }
+ ],
+ "relatedGenes": [
+ {
+ "id": "PA28469",
+ "name": "glucose-6-phosphate dehydrogenase",
+ "symbol": "G6PD"
+ }
+ ],
+ "relatedAlleles": [],
+ "recommendation": false
+ },
+ "recommendations": [
+ {
+ "id": "PA166345901",
+ "name": "Recommendation Annotation PA166345901",
+ "population": null,
+ "classification": null,
+ "relatedChemicals": [
+ {
+ "id": "PA450640",
+ "name": "nitrofurantoin",
+ "symbol": null
+ }
+ ],
+ "text": {
+ "id": 1452539580,
+ "html": "The nitrofurantoin (Furadantin) label states: "Cases of hemolytic anemia of the primaquine-sensitivity type have been induced by nitrofurantoin. Hemolysis appears to be linked to a glucose-6-phosphate dehydrogenase deficiency in the red blood cells of the affected patients. [...] Hemolysis is an indication for discontinuing Furadantin; hemolysis ceases when the drug is withdrawn." See label for more information.
\n"
+ },
+ "implications": [],
+ "lookupKey": {
+ "G6PD": "Deficient"
+ },
+ "dosingInformation": false,
+ "alternateDrugAvailable": true,
+ "otherPrescribingGuidance": false
+ },
+ {
+ "id": "PA166345881",
+ "name": "Recommendation Annotation PA166345881",
+ "population": null,
+ "classification": null,
+ "relatedChemicals": [
+ {
+ "id": "PA450640",
+ "name": "nitrofurantoin",
+ "symbol": null
+ }
+ ],
+ "text": {
+ "id": 1452539560,
+ "html": "The nitrofurantoin (Furadantin) label states: "Cases of hemolytic anemia of the primaquine-sensitivity type have been induced by nitrofurantoin. Hemolysis appears to be linked to a glucose-6-phosphate dehydrogenase deficiency in the red blood cells of the affected patients. [...] Hemolysis is an indication for discontinuing Furadantin; hemolysis ceases when the drug is withdrawn." See label for more information.
\n"
+ },
+ "implications": [],
+ "lookupKey": {
+ "G6PD": "Deficient with CNSHA"
+ },
+ "dosingInformation": false,
+ "alternateDrugAvailable": true,
+ "otherPrescribingGuidance": false
+ },
+ {
+ "id": "PA166345902",
+ "name": "Recommendation Annotation PA166345902",
+ "population": null,
+ "classification": null,
+ "relatedChemicals": [
+ {
+ "id": "PA450640",
+ "name": "nitrofurantoin",
+ "symbol": null
+ }
+ ],
+ "text": {
+ "id": 1452539581,
+ "html": "The nitrofurantoin (Furadantin) label states: "Cases of hemolytic anemia of the primaquine-sensitivity type have been induced by nitrofurantoin. Hemolysis appears to be linked to a glucose-6-phosphate dehydrogenase deficiency in the red blood cells of the affected patients. [...] Hemolysis is an indication for discontinuing Furadantin; hemolysis ceases when the drug is withdrawn." See label for more information.
\n"
+ },
+ "implications": [],
+ "lookupKey": {
+ "G6PD": "Variable"
+ },
+ "dosingInformation": false,
+ "alternateDrugAvailable": true,
+ "otherPrescribingGuidance": false
+ }
+ ],
+ "citations": [
+ {
+ "pmid": null,
+ "title": "Drugs@FDA: Drug Product Furadantin (Nitrofurantoin), NDA009175, Casper Pharma LLC",
+ "journal": null,
+ "year": -1,
+ "_sameAs": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varApplNo=009175"
+ }
+ ],
+ "url": "https://www.pharmgkb.org/labelAnnotation/PA166104903"
+ },
{
"guideline": {
"id": "PA166225161",
diff --git a/src/test/java/org/pharmgkb/pharmcat/PipelineTest.java b/src/test/java/org/pharmgkb/pharmcat/PipelineTest.java
index 8b169021..a957dbde 100644
--- a/src/test/java/org/pharmgkb/pharmcat/PipelineTest.java
+++ b/src/test/java/org/pharmgkb/pharmcat/PipelineTest.java
@@ -425,7 +425,7 @@ void testCounts(TestInfo testInfo) throws Exception {
.flatMap((k) -> testWrapper.getContext().getDrugReports().get(k).values().stream()
.map(DrugReport::getName))
.collect(Collectors.toCollection(TreeSet::new));
- assertEquals(177, drugs.size());
+ assertEquals(184, drugs.size());
}
@Test