diff --git a/cmake/defaults/Options.cmake b/cmake/defaults/Options.cmake
index 6c118a9479..5c2a78cb31 100644
--- a/cmake/defaults/Options.cmake
+++ b/cmake/defaults/Options.cmake
@@ -72,7 +72,7 @@ option(PXR_ENABLE_GL_SUPPORT "Enable OpenGL based components" ON)
 
 # Precompiled headers are a win on Windows, not on gcc.
 set(pxr_enable_pch "OFF")
-if(MSVC)
+if(MSVC AND NOT CMAKE_GENERATOR STREQUAL "Ninja")
     set(pxr_enable_pch "ON")
 endif()
 option(PXR_ENABLE_PRECOMPILED_HEADERS "Enable precompiled headers." "${pxr_enable_pch}")