partial_thread.default.linuxgccrelease: error while loading shared libraries: libcifparse.so: cannot open shared object file: No such file or directory

[bananaguard1]

Hi,
I'm trying out comparative modeling under RosettaCM but I keep getting this error message:
partial_thread.default.linuxgccrelease: error while loading shared libraries: libcifparse.so: cannot open shared object file: No such file or directory

I followed the tutorial on RosettaCM and was trying to set up the threaded model using this command:
Rosetta/main/source/bin/partial_thread.linuxgccrelease
-database Rosetta/main/database
-in:file:fasta target.fasta
-in:file:alignment alignment.aln
-in:file:template_pdb 1k3d.pdb 1y12.pdb
-ignore_unrecognized_res

Please tell me what I'm doing wrong.
I am quite new to Rosetta and would appreciate any help.

[roccomoretti]

This error typically happens when you move the Rosetta directory (either directly, or if you're mounting it at a different location than which you compiled it at.)

For Rosetta to find the libraries it needs, it encodes the compilation directory into the executables. This means that when the Rosetta directory can't be found at the path where it was compiled, then Rosetta can't find the library.

The fix would be to re-run the compilation command from the path where you're going to run it. This should be relatively fast, as it doesn't need to actually recompile everything, it just needs to update the paths in the final executables.

Alternatively, if you're in a situation where you need to access the executables from multiple different directory locations, you can add the extras=static directive to the scons command line, to tell the compilation to build all the libraries into the executable. (This is how the pre-compiled versions of Rosetta are distributed.) -- The only trick is that you'd want to adjust the executable name from partial_thread.linuxgccrelease to partial_thread.static.linuxgccrelease.