Mitra2019Rab
A model of Rab5 and Rab7 activation and EGFR degradation in response to stimulation with EGF.
This model is supplementary material for the following manuscript in preparation:
Shideler T, Palsuledesai C, Suderman R, Mitra E, Cleyrat C, Hlavacek WS, Wandinger-Ness A. A High Dose of EGF Promotes EGFR Degradation by Increasing Rab7 Activity.
- rab_wt.bngl - Wild type model
- rab_mon1ccz1_ox.bngl - Model with overexpression of Mon1 and Ccz1
- rab_rab5_ox - Model with overexpression of Rab5
- rab_rab7_ox - Model with overexpression of Rab7
- pybnf_files - Model, data, and configuration files required to run model parameterization in PyBioNetFit
This model was parameterized using PyBioNetFit v1.0.0