diff --git a/requirements.txt b/requirements.txt
index 31382e394..00da89033 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,7 +1,5 @@
-lxml>=4.4.1
 matplotlib>=3.0.3
 plotly>=4.1.0
-python_libsbml>=5.18.0
 scipy>=1.3.1
 setuptools>=41.0.1
 tqdm>=4.23.4