diff --git a/setup.py b/setup.py
index a165c96b..65462156 100644
--- a/setup.py
+++ b/setup.py
@@ -43,7 +43,7 @@
     install_requires=[
         "numpy>=1.24",
         "cloudpickle>=1.6.0",
-        "substra~=0.49.0",
+        "substra~=0.50.0rc2",
         "substratools~=0.21.0",
         "pydantic>=2.3.0,<3.0",
         "pip>=21.2",
diff --git a/substrafl/__version__.py b/substrafl/__version__.py
index 67d0e2f8..1604afd1 100644
--- a/substrafl/__version__.py
+++ b/substrafl/__version__.py
@@ -1 +1 @@
-__version__ = "0.43.0rc1"
+__version__ = "0.43.0rc2"