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advan3.html
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<HTML><HEAD> <TITLE> advan3.ppp</TITLE><HEAD>
<BODY BGCOLOR="#FFFFFF">
<PRE>
+--------------------------------------------------------------------+
| |
| ADVAN3 |
| |
+--------------------------------------------------------------------+
MEANING: Choice of Pharmacokinetic Model for PREDPP
CONTEXT: Option of NM-TRAN $SUBROUTINES record
USAGE:
$SUBROUTINES [ADVAN=]ADVAN3
SAMPLE:
$SUBROUTINE ADVAN3
DISCUSSION:
ADVAN3 is a routine in PREDPP's library which implements the kinetic
equations for the Two Compartment Linear Model.
Compt. Function Initial On/Off Dose Default Default
No. Status Allowed Allowed for Dose for Obs.
1 Central On No Yes Yes Yes
2 Peripheral On No Yes No No
3 Output Off Yes No No No
TRANS routines that may be used: TRANS1, TRANS3, TRANS4, TRANS5,
TRANS6
Basic PK parameters with TRANS1:
K (rate constant of elimination)
K12 (rate constant from central to peripheral)
K21 (rate constant from peripheral to central)
Basic PK parameters with TRANS3: (See <A HREF="t.html#trans3">TRANS3</A>).
Basic PK parameters with TRANS4: (See <A HREF="t.html#trans4">TRANS4</A>).
Basic PK parameters with TRANS5: (See <A HREF="t.html#trans5">TRANS5</A>).
Basic PK parameters with TRANS6: (See <A HREF="t.html#trans6">TRANS6</A>).
Additional PK parameters:
S1 - Scale for central compartment (also called SC)
S2 - Scale for peripheral compartment
S3 - Scale for output compartment (also called S0)
F1 - Bioavailability for central compartment
F2 - Bioavailability for peripheral compartment
R1 - Rate for central compartment
R2 - Rate for peripheral compartment
D1 - Duration for central compartment
D2 - Duration for peripheral compartment
ALAG1 - Absorption lag for central compartment
ALAG2 - Absorption lag for peripheral compartment
F0 - Output fraction (also called F3, FO)
XSCALE - Time scale
MTIME(i) - Model event times
REFERENCES: Guide VI Section <a href="VI/VII.html#C.3.">VII.C.3<a/>
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