ncappc: NCA Calculations and Population Model Diagnosis

A flexible tool that can perform:

1. Traditional non-compartmental analysis (NCA) and
2. Simulation-based posterior predictive checks for population pharmacokinetic (PK) and/or pharmacodynamic (PKPD) models using NCA metrics.

Installation

You need to have R installed. Download the latest version of R from www.r-project.org. Install ncappc in R using one of the following methods:

• latest stable release -- From CRAN. Write at the R command line:

install.packages("ncappc")

• Latest development version -- from Github. Note that the command below installs the "master" (development) branch; if you want the release branch from Github add ref="release" to the install_github() call. The install_github() approach requires that you build from source, i.e. make and compilers must be installed on your system -- see the R FAQ for your operating system; you may also need to install dependencies manually.

devtools::install_github("UUPharmacometrics/ncappc",build_vignettes=TRUE)