diff --git a/.editorconfig b/.editorconfig
index f5444d81a74..572b73bd2ed 100644
--- a/.editorconfig
+++ b/.editorconfig
@@ -10,3 +10,7 @@ insert_final_newline = true
 indent_style = space
 indent_size = 2
 trim_trailing_whitespace = false
+
+[*.yml]
+indent_style = space
+indent_size = 2
diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
new file mode 100644
index 00000000000..d59f8e1ec61
--- /dev/null
+++ b/.github/workflows/wheels.yml
@@ -0,0 +1,136 @@
+name: Build Wheels for PyPI
+on:
+  workflow_dispatch:
+
+jobs:
+  build_wheels:
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [
+            {
+              name: "Ubuntu 22.04",
+              family: "linux",
+              runner: "ubuntu-22.04",
+              archs: "x86_64",
+            },
+            ## Aarch64 is disabled for now: GitHub is committing to EOY
+            ## for free aarch64 runners for open-source projects and
+            ## emulation times out:
+            ## https://github.com/orgs/community/discussions/19197#discussioncomment-10550689
+            # {
+            #   name: "Ubuntu 22.04",
+            #   family: "linux",
+            #   runner: "ubuntu-22.04",
+            #   archs: "aarch64",
+            # },
+            {
+              name: "macOS 13",
+              family: "macos",
+              runner: "macos-13",
+              archs: "x86_64",
+            },
+            {
+              name: "macOS 14",
+              family: "macos",
+              runner: "macos-14",
+              archs: "arm64",
+            },
+            ## Windows is disabled because of an issue with compiling FFI as
+            ## under MinGW in the GitHub Actions environment (SHELL variable has
+            ## whitespace.)
+            # {
+            #   name: "Windows Server 2019",
+            #   family: "windows",
+            #   runner: "windows-2019",
+            #   archs: "AMD64",
+            # },
+          ]
+    name: Build Wheels | ${{ matrix.os.name }} | ${{ matrix.os.archs }}
+    runs-on: ${{ matrix.os.runner }}
+    steps:
+      - uses: actions/checkout@v4
+        with:
+          fetch-depth: 0
+          submodules: true
+      - if: ${{ matrix.os.family == 'linux' }}
+        name: "[Linux] Set up QEMU"
+        uses: docker/setup-qemu-action@v3
+      - uses: actions/setup-python@v5
+      - name: Get Boost Source
+        shell: bash
+        run: |
+          mkdir -p boost
+          curl -L https://github.com/boostorg/boost/releases/download/boost-1.86.0/boost-1.86.0-b2-nodocs.tar.gz | tar --strip-components=1 -xzC boost
+      - name: Get FFI
+        shell: bash
+        run: |
+          mkdir -p ffi
+          curl -L https://github.com/libffi/libffi/releases/download/v3.4.6/libffi-3.4.6.tar.gz | tar --strip-components=1 -xzC ffi
+      ## Software installed by default in GitHub Action Runner VMs:
+      ##  https://github.com/actions/runner-images
+      - if: ${{ matrix.os.family == 'macos' }}
+        name: "[macOS] Flex/Bison"
+        run: |
+          brew install flex bison
+          echo "PATH=$(brew --prefix flex)/bin:$PATH" >> $GITHUB_ENV
+          echo "PATH=$(brew --prefix bison)/bin:$PATH" >> $GITHUB_ENV
+      - if: ${{ matrix.os.family == 'windows' }}
+        name: "[Windows] Flex/Bison"
+        run: |
+          choco install winflexbison3
+      - if: ${{ matrix.os.family == 'macos' && matrix.os.archs == 'arm64' }}
+        name: "[macOS/arm64] Install Python 3.8 (see: https://cibuildwheel.pypa.io/en/stable/faq/#macos-building-cpython-38-wheels-on-arm64)"
+        uses: actions/setup-python@v5
+        with:
+          python-version: 3.8
+      - name: Build wheels
+        uses: pypa/cibuildwheel@v2.21.1
+        env:
+          # * APIs not supported by PyPy
+          # * Musllinux disabled because it increases build time from 48m to ~3h
+          CIBW_SKIP: >
+            pp*
+            *musllinux*
+          CIBW_ARCHS: ${{ matrix.os.archs }}
+          CIBW_BUILD_VERBOSITY: "1"
+          # manylinux2014 (default) does not have a modern enough C++ compiler for Yosys
+          CIBW_MANYLINUX_X86_64_IMAGE: manylinux_2_28
+          CIBW_MANYLINUX_AARCH64_IMAGE: manylinux_2_28
+          CIBW_BEFORE_ALL: bash ./.github/workflows/wheels/cibw_before_all.sh
+          CIBW_ENVIRONMENT: >
+            CXXFLAGS=-I./boost/pfx/include
+            LINKFLAGS=-L./boost/pfx/lib
+            PKG_CONFIG_PATH=./ffi/pfx/lib/pkgconfig
+            makeFlags='BOOST_PYTHON_LIB=./boost/pfx/lib/libboost_python*.a'
+          CIBW_ENVIRONMENT_MACOS: >
+            CXXFLAGS=-I./boost/pfx/include
+            LINKFLAGS=-L./boost/pfx/lib
+            PKG_CONFIG_PATH=./ffi/pfx/lib/pkgconfig
+            MACOSX_DEPLOYMENT_TARGET=11
+            makeFlags='BOOST_PYTHON_LIB=./boost/pfx/lib/libboost_python*.a CONFIG=clang'
+          CIBW_BEFORE_BUILD: bash ./.github/workflows/wheels/cibw_before_build.sh
+          CIBW_TEST_COMMAND: python3 -c "from pyosys import libyosys as ys;d=ys.Design();ys.run_pass('help', d)"
+      - uses: actions/upload-artifact@v4
+        with:
+          name: python-wheels-${{ matrix.os.runner }}
+          path: ./wheelhouse/*.whl
+  upload_wheels:
+    name: Upload Wheels
+    runs-on: ubuntu-latest
+    needs: build_wheels
+    steps:
+      - uses: actions/download-artifact@v4
+        with:
+          path: "."
+          pattern: python-wheels-*
+          merge-multiple: true
+      - run: |
+          ls
+          mkdir -p ./dist
+          mv *.whl ./dist
+      - name: Publish
+        uses: pypa/gh-action-pypi-publish@release/v1
+        with:
+          password: ${{ secrets.PYPI_TOKEN }}
+          repository-url: ${{ vars.PYPI_INDEX || 'https://upload.pypi.org/legacy/' }}
diff --git a/.github/workflows/wheels/_run_cibw_linux.py b/.github/workflows/wheels/_run_cibw_linux.py
new file mode 100644
index 00000000000..894470a5a8d
--- /dev/null
+++ b/.github/workflows/wheels/_run_cibw_linux.py
@@ -0,0 +1,44 @@
+#!/usr/bin/env python3
+# Copyright (C) 2024 Efabless Corporation
+#
+# Permission to use, copy, modify, and/or distribute this software for any
+# purpose with or without fee is hereby granted, provided that the above
+# copyright notice and this permission notice appear in all copies.
+#
+# THE SOFTWARE IS PROVIDED "AS IS" AND THE AUTHOR DISCLAIMS ALL WARRANTIES
+# WITH REGARD TO THIS SOFTWARE INCLUDING ALL IMPLIED WARRANTIES OF
+# MERCHANTABILITY AND FITNESS. IN NO EVENT SHALL THE AUTHOR BE LIABLE FOR
+# ANY SPECIAL, DIRECT, INDIRECT, OR CONSEQUENTIAL DAMAGES OR ANY DAMAGES
+# WHATSOEVER RESULTING FROM LOSS OF USE, DATA OR PROFITS, WHETHER IN AN
+# ACTION OF CONTRACT, NEGLIGENCE OR OTHER TORTIOUS ACTION, ARISING OUT OF
+# OR IN CONNECTION WITH THE USE OR PERFORMANCE OF THIS SOFTWARE.
+"""
+This runs the cibuildwheel step from the wheels workflow locally.
+"""
+
+import os
+import yaml
+import platform
+import subprocess
+
+__dir__ = os.path.dirname(os.path.abspath(__file__))
+
+
+workflow = yaml.safe_load(open(os.path.join(os.path.dirname(__dir__), "wheels.yml")))
+
+env = os.environ.copy()
+
+steps = workflow["jobs"]["build_wheels"]["steps"]
+cibw_step = None
+for step in steps:
+    if (step.get("uses") or "").startswith("pypa/cibuildwheel"):
+        cibw_step = step
+        break
+
+for key, value in cibw_step["env"].items():
+    if key.endswith("WIN") or key.endswith("MAC"):
+        continue
+    env[key] = value
+
+env["CIBW_ARCHS"] = os.getenv("CIBW_ARCHS") or platform.machine()
+subprocess.check_call(["cibuildwheel"], env=env)
diff --git a/.github/workflows/wheels/cibw_before_all.sh b/.github/workflows/wheels/cibw_before_all.sh
new file mode 100644
index 00000000000..fbb8dcad830
--- /dev/null
+++ b/.github/workflows/wheels/cibw_before_all.sh
@@ -0,0 +1,23 @@
+set -e
+set -x
+
+# Build-time dependencies
+## Linux Docker Images
+if command -v yum &> /dev/null; then
+    yum install -y flex bison
+fi
+
+if command -v apk &> /dev/null; then
+    apk add flex bison
+fi
+
+## macOS/Windows -- installed in GitHub Action itself, not container
+
+# Build Static FFI (platform-dependent but not Python version dependent)
+cd ffi
+## Ultimate libyosys.so will be shared, so we need fPIC for the static libraries
+CFLAGS=-fPIC CXXFLAGS=-fPIC ./configure --prefix=$PWD/pfx
+## Without this, SHELL has a space in its path which breaks the makefile
+make install -j$(getconf _NPROCESSORS_ONLN 2>/dev/null || sysctl -n hw.ncpu)
+## Forces static library to be used in all situations
+sed -i.bak 's@-L${toolexeclibdir} -lffi@${toolexeclibdir}/libffi.a@' ./pfx/lib/pkgconfig/libffi.pc
diff --git a/.github/workflows/wheels/cibw_before_build.sh b/.github/workflows/wheels/cibw_before_build.sh
new file mode 100644
index 00000000000..018b0e0df96
--- /dev/null
+++ b/.github/workflows/wheels/cibw_before_build.sh
@@ -0,0 +1,34 @@
+set -e
+set -x
+
+# Don't use objects from previous compiles on Windows/macOS
+make clean
+
+# DEBUG: show python3 and python3-config outputs
+if [ "$(uname)" != "Linux" ]; then
+    # https://github.com/pypa/cibuildwheel/issues/2021
+    ln -s $(dirname $(readlink -f $(which python3)))/python3-config $(dirname $(which python3))/python3-config
+fi
+python3 --version
+python3-config --includes
+
+# Build boost
+cd ./boost
+## Delete the artefacts from previous builds (if any)
+rm -rf ./pfx
+## Bootstrap bjam
+./bootstrap.sh --prefix=./pfx
+## Build Boost against current version of Python, only for
+## static linkage (Boost is statically linked because system boost packages
+## wildly vary in versions, including the libboost_python3 version)
+./b2\
+    -j$(getconf _NPROCESSORS_ONLN 2>/dev/null || sysctl -n hw.ncpu)\
+    --prefix=./pfx\
+    --with-filesystem\
+    --with-system\
+    --with-python\
+    cxxflags="$(python3-config --includes) -std=c++17 -fPIC"\
+    cflags="$(python3-config --includes) -fPIC"\
+    link=static\
+    variant=release\
+    install
diff --git a/.gitignore b/.gitignore
index e82343e8947..5c3d8f4e963 100644
--- a/.gitignore
+++ b/.gitignore
@@ -45,4 +45,10 @@ __pycache__
 /tests/unit/bintest/
 /tests/unit/objtest/
 /tests/ystests
-/result
\ No newline at end of file
+/result
+/dist
+/*.egg-info
+/build
+/venv
+/boost
+/ffi
diff --git a/Makefile b/Makefile
index 92274a56d67..f4276b94d9b 100644
--- a/Makefile
+++ b/Makefile
@@ -742,7 +742,7 @@ $(PROGRAM_PREFIX)yosys$(EXE): $(OBJS)
 
 libyosys.so: $(filter-out kernel/driver.o,$(OBJS))
 ifeq ($(OS), Darwin)
-	$(P) $(CXX) -o libyosys.so -shared -Wl,-install_name,$(LIBDIR)/libyosys.so $(LINKFLAGS) $^ $(LIBS) $(LIBS_VERIFIC)
+	$(P) $(CXX) -o libyosys.so -shared -undefined dynamic_lookup -Wl,-install_name,$(LIBDIR)/libyosys.so $(LINKFLAGS) $^ $(LIBS) $(LIBS_VERIFIC)
 else
 	$(P) $(CXX) -o libyosys.so -shared -Wl,-soname,$(LIBDIR)/libyosys.so $(LINKFLAGS) $^ $(LIBS) $(LIBS_VERIFIC)
 endif
diff --git a/kernel/yosys.cc b/kernel/yosys.cc
index efdc54b796c..510151479b6 100644
--- a/kernel/yosys.cc
+++ b/kernel/yosys.cc
@@ -555,10 +555,15 @@ void yosys_setup()
 #undef X
 
 	#ifdef WITH_PYTHON
-		PyImport_AppendInittab((char*)"libyosys", INIT_MODULE);
-		Py_Initialize();
-		PyRun_SimpleString("import sys");
-		signal(SIGINT, SIG_DFL);
+		// With Python 3.12, calling PyImport_AppendInittab on an already
+		// initialized platform fails (such as when libyosys is imported
+		// from a Python interpreter)
+		if (!Py_IsInitialized()) {
+			PyImport_AppendInittab((char*)"libyosys", INIT_MODULE);
+			Py_Initialize();
+			PyRun_SimpleString("import sys");
+			signal(SIGINT, SIG_DFL);
+		}
 	#endif
 
 	Pass::init_register();
diff --git a/setup.py b/setup.py
new file mode 100644
index 00000000000..22196597109
--- /dev/null
+++ b/setup.py
@@ -0,0 +1,97 @@
+#!/usr/bin/env python3
+# Copyright (C) 2024 Efabless Corporation
+#
+# Permission to use, copy, modify, and/or distribute this software for any
+# purpose with or without fee is hereby granted, provided that the above
+# copyright notice and this permission notice appear in all copies.
+#
+# THE SOFTWARE IS PROVIDED "AS IS" AND THE AUTHOR DISCLAIMS ALL WARRANTIES
+# WITH REGARD TO THIS SOFTWARE INCLUDING ALL IMPLIED WARRANTIES OF
+# MERCHANTABILITY AND FITNESS. IN NO EVENT SHALL THE AUTHOR BE LIABLE FOR
+# ANY SPECIAL, DIRECT, INDIRECT, OR CONSEQUENTIAL DAMAGES OR ANY DAMAGES
+# WHATSOEVER RESULTING FROM LOSS OF USE, DATA OR PROFITS, WHETHER IN AN
+# ACTION OF CONTRACT, NEGLIGENCE OR OTHER TORTIOUS ACTION, ARISING OUT OF
+# OR IN CONNECTION WITH THE USE OR PERFORMANCE OF THIS SOFTWARE.
+import os
+import re
+import shlex
+import shutil
+from setuptools import setup, Extension
+from setuptools.command.build_ext import build_ext
+
+__dir__ = os.path.dirname(os.path.abspath(__file__))
+
+yosys_version_rx = re.compile(r"YOSYS_VER\s*:=\s*([\w\-\+\.]+)")
+
+version = yosys_version_rx.search(
+    open(os.path.join(__dir__, "Makefile"), encoding="utf8").read()
+)[1].replace(
+    "+", "."
+)  # Convert to patch version
+
+
+class libyosys_so_ext(Extension):
+    def __init__(
+        self,
+    ) -> None:
+        super().__init__(
+            "libyosys.so",
+            [],
+        )
+        self.args = [
+            "ENABLE_PYOSYS=1",
+            # Wheel meant to be imported from interpreter
+            "ENABLE_PYTHON_CONFIG_EMBED=0",
+            # Would need to be installed separately by the user
+            "ENABLE_TCL=0",
+            # Would need to be installed separately by the user
+            "ENABLE_READLINE=0",
+            # Show compile commands
+            "PRETTY=0",
+        ]
+
+    def custom_build(self, bext: build_ext):
+        bext.spawn(
+            ["make", f"-j{os.cpu_count() or 1}", self.name]
+            + shlex.split(os.getenv("makeFlags", ""))
+            + self.args
+        )
+        build_path = os.path.dirname(os.path.dirname(bext.get_ext_fullpath(self.name)))
+        pyosys_path = os.path.join(build_path, "pyosys")
+        target = os.path.join(pyosys_path, os.path.basename(self.name))
+        os.makedirs(pyosys_path, exist_ok=True)
+        shutil.copyfile(self.name, target)
+
+        # I don't know how debug info is getting here.
+        bext.spawn(["strip", "-S", target])
+
+
+class custom_build_ext(build_ext):
+    def build_extension(self, ext) -> None:
+        if not hasattr(ext, "custom_build"):
+            return super().build_extension(ext)
+        return ext.custom_build(self)
+
+
+setup(
+    name="pyosys",
+    packages=["pyosys"],
+    version=version,
+    description="Python access to libyosys",
+    long_description=open(os.path.join(__dir__, "README.md")).read(),
+    long_description_content_type="text/markdown",
+    install_requires=["wheel", "setuptools"],
+    classifiers=[
+        "License :: OSI Approved :: MIT License",
+        "Programming Language :: Python :: 3",
+        "Intended Audience :: Developers",
+        "Operating System :: POSIX :: Linux",
+        "Operating System :: MacOS :: MacOS X",
+    ],
+    package_dir={"pyosys": "misc"},
+    python_requires=">=3.8",
+    ext_modules=[libyosys_so_ext()],
+    cmdclass={
+        "build_ext": custom_build_ext,
+    },
+)