diff --git a/specs/adc-api-openapi3.yaml b/specs/adc-api-openapi3.yaml
index 5a909f1c3..848e40cb9 100644
--- a/specs/adc-api-openapi3.yaml
+++ b/specs/adc-api-openapi3.yaml
@@ -371,6 +371,12 @@ components:
       items:
         $ref: 'https://raw.githubusercontent.com/airr-community/airr-standards/v1.4.1/specs/airr-schema-openapi3.yaml#/CellExpression'
 
+    # list of cell reactivity features
+    reactivity_list:
+      type: array
+      items:
+        $ref: 'https://raw.githubusercontent.com/airr-community/airr-standards/v1.4.1/specs/airr-schema-openapi3.yaml#/CellReactivity'
+
     # list of receptor extension fields
     receptor_extension:
       description: The extended Receptor object with additional query fields for the ADC.
@@ -465,6 +471,26 @@ components:
         Facet:
           $ref: '#/components/schemas/facet_list'
 
+    # The response object /reactivity/{reactivity_id} endpoint
+    reactivity_id_response:
+      type: object
+      properties:
+        Info:
+          $ref: '#/components/schemas/info_object'
+        CellReactivity:
+          $ref: '#/components/schemas/reactivity_list'
+
+    # The response object for the /reactivity endpoint
+    reactivity_response:
+      type: object
+      properties:
+        Info:
+          $ref: '#/components/schemas/info_object'
+        CellReactivity:
+          $ref: '#/components/schemas/reactivity_list'
+        Facet:
+          $ref: '#/components/schemas/facet_list'
+
     # The response object /receptor endpoint
     receptor_response:
       type: object
@@ -996,6 +1022,75 @@ paths:
               schema:
                 $ref: '#/components/schemas/error_response'
 
+  /reactivity/{reactivity_id}:
+    x-swagger-router-controller: reactivity
+    get:
+      description: >
+        Returns an reactivity property based upon its identifier.
+      tags:
+        - reactivity
+      parameters:
+        - name: reactivity_id
+          in: path
+          description: ID of reactivity property to return
+          required: true
+          schema:
+            type: string
+      operationId: get_reactivity
+      responses:
+        '200':
+          description: >
+            A successful call returns the reactivity property data.
+          content:
+            application/json:
+              schema:
+                $ref: '#/components/schemas/reactivity_id_response'
+        '400':
+          description: Invalid request
+          content:
+            application/json:
+              schema:
+                $ref: '#/components/schemas/error_response'
+        '500':
+          description: Server error
+          content:
+            application/json:
+              schema:
+                $ref: '#/components/schemas/error_response'
+  
+  /reactivity:
+    post:
+      description: >
+        This query service returns gene reactivity data.
+      operationId: query_reactivity
+      tags:
+        - reactivity
+      requestBody:
+        content:
+          application/json:
+            schema:
+              $ref: '#/components/schemas/query_object'
+      responses:
+        '200':
+          description: >
+            A successful call returns an array of gene reactivity data.
+          content:
+            application/json:
+              schema:
+                $ref: '#/components/schemas/reactivity_response'
+        '400':
+          description: Invalid request
+          content:
+            application/json:
+              schema:
+                $ref: '#/components/schemas/error_response'
+        '500':
+          description: Server error
+          content:
+            application/json:
+              schema:
+                $ref: '#/components/schemas/error_response'
+
   /receptor/{receptor_id}:
     get:
       description: >
diff --git a/specs/adc-api.yaml b/specs/adc-api.yaml
index 24142bb2d..fda385b86 100644
--- a/specs/adc-api.yaml
+++ b/specs/adc-api.yaml
@@ -416,6 +416,32 @@ definitions:
       Facet:
         $ref: '#/definitions/facet_list'
 
+  # list of reactivity annotations
+  reactivity_list:
+    type: array
+    items:
+      $ref: 'https://raw.githubusercontent.com/airr-community/airr-standards/v1.4.1/specs/airr-schema.yaml#/CellReactivity'
+
+  # The response object /reactivity/{reactivity_id} endpoint
+  reactivity_id_response:
+    type: object
+    properties:
+      Info:
+        $ref: '#/definitions/info_object'
+      CellReactivity:
+        $ref: '#/definitions/reactivity_list'
+
+  # The response object /reactivity endpoint
+  reactivity_response:
+    type: object
+    properties:
+      Info:
+        $ref: '#/definitions/info_object'
+      CellReactivity:
+        $ref: '#/definitions/reactivity_list'
+      Facet:
+        $ref: '#/definitions/facet_list'
+
   # list of receptor extension fields
   receptor_extension:
     description: The extended Receptor object with additional query fields for the ADC.
@@ -1035,6 +1061,94 @@ paths:
           schema:
             $ref: '#/definitions/error_response'
 
+  /reactivity/{reactivity_id}:
+    x-swagger-router-controller: reactivity
+    get:
+      description: >
+        Returns an reactivity property based upon its identifier.
+      tags:
+        - reactivity
+      consumes:
+        - application/x-www-form-urlencoded
+        - application/json
+        - application/octet-stream
+      produces:
+        - application/json
+      parameters:
+        - name: reactivity_id
+          in: path
+          description: ID of reactivity property to return
+          required: true
+          type: string
+      operationId: getReactivity
+      responses:
+        '200':
+          description: >
+            A successful call returns the reactivity property data.
+          schema:
+            $ref: '#/definitions/reactivity_id_response'
+        '400':
+          description: Invalid request
+          schema:
+            $ref: '#/definitions/error_response'
+        '500':
+          description: Server error
+          schema:
+            $ref: '#/definitions/error_response'
+
+  /reactivity:
+    x-swagger-router-controller: reactivity
+    post:
+      description: >
+        This query service returns cell reactivity data.
+      tags:
+        - reactivity
+      parameters:
+        - in: body
+          name: data
+          schema:
+            type: object
+            properties:
+              filters:
+                type: object
+              format:
+                type: string
+                default: json
+                enum:
+                  - json
+                  - tsv
+              fields:
+                type: array
+                items:
+                  type: string
+              size:
+                type: integer
+              from:
+                type: integer
+              include_fields:
+                type: string
+                enum:
+                  - miairr
+                  - airr-core
+                  - airr-schema
+              facets:
+                type: string
+      operationId: queryReactivity
+      responses:
+        '200':
+          description: >
+            A successful call returns an array of cell reactivity data.
+          schema:
+            $ref: '#/definitions/reactivity_response'
+        '400':
+          description: Invalid request
+          schema:
+            $ref: '#/definitions/error_response'
+        '500':
+          description: Server error
+          schema:
+            $ref: '#/definitions/error_response'
+
   /receptor/{receptor_id}:
     x-swagger-router-controller: receptor
     get: