diff --git a/public/gh-reroute/index.tsx b/public/gh-reroute/index.tsx
index 578a5a44..aa468d02 100644
--- a/public/gh-reroute/index.tsx
+++ b/public/gh-reroute/index.tsx
@@ -1,4 +1,4 @@
-import { convertUrlToQueryStringPath } from "../../website/utils/gh_route_utils";
+import { encodeGitHubPagesUrl } from "../../website/utils/gh_route_utils";
 
 // Hide the default 404 page content and just show a blank screen.
 // The content should only be shown if the browser doesn't support JavaScript.
@@ -10,6 +10,6 @@ window.onload = () => {
 // Convert the current URL to a query string path and redirect the browser.
 const location = window.location;
 const locationUrl = new URL(location.toString());
-const newUrl = convertUrlToQueryStringPath(locationUrl, 1);
+const newUrl = encodeGitHubPagesUrl(locationUrl);
 location.replace(newUrl);
 console.log("Redirecting to " + newUrl.toString());
diff --git a/public/index.tsx b/public/index.tsx
index a7a5c488..8a5a5fde 100644
--- a/public/index.tsx
+++ b/public/index.tsx
@@ -2,12 +2,14 @@ import React from "react";
 import ReactDOM from "react-dom";
 import { createBrowserRouter, RouterProvider } from "react-router-dom";
 
+import { decodeGitHubPagesUrl, isEncodedPathUrl, tryRemoveHashRouting } from "../website/utils/gh_route_utils";
+
+import StyleProvider from "../src/aics-image-viewer/components/StyleProvider";
 // Components
 import AppWrapper from "../website/components/AppWrapper";
-import LandingPage from "../website/components/LandingPage";
 import ErrorPage from "../website/components/ErrorPage";
-import { isQueryStringPath, convertQueryStringPathToUrl } from "../website/utils/gh_route_utils";
-import StyleProvider from "../src/aics-image-viewer/components/StyleProvider";
+import LandingPage from "../website/components/LandingPage";
+
 import "./App.css";
 
 // vars filled at build time using webpack DefinePlugin
@@ -18,11 +20,11 @@ console.log(`volume-viewer Version ${VOLUMEVIEWER_VERSION}`);
 
 const basename = WEBSITE3DCELLVIEWER_BASENAME;
 
-// Check for redirects in the query string, and update browser history state.
+// Decode URL path if it was encoded for GitHub pages or uses hash routing.
 const locationUrl = new URL(window.location.toString());
-if (isQueryStringPath(locationUrl)) {
-  const url = convertQueryStringPathToUrl(locationUrl);
-  const newRelativePath = url.pathname + url.search + url.hash;
+if (locationUrl.hash !== "" || isEncodedPathUrl(locationUrl)) {
+  const decodedUrl = tryRemoveHashRouting(decodeGitHubPagesUrl(locationUrl));
+  const newRelativePath = decodedUrl.pathname + decodedUrl.search + decodedUrl.hash;
   console.log("Redirecting to " + newRelativePath);
   // Replaces the query string path with the original path now that the
   // single-page app has loaded. This lets routing work as normal below.
diff --git a/website/utils/gh_route_utils.ts b/website/utils/gh_route_utils.ts
index 407afc02..343dd16a 100644
--- a/website/utils/gh_route_utils.ts
+++ b/website/utils/gh_route_utils.ts
@@ -1,7 +1,7 @@
 const ESCAPED_AMPERSAND = "~and~";
 
 /**
- * Converts the path component of a URL into a query string. Used to redirect the browser
+ * Encodes the path component of a URL into a query string. Used to redirect the browser
  * for single-page apps when the server is not configured to serve the app for all paths,
  * e.g. GitHub pages.
  *
@@ -23,7 +23,7 @@ const ESCAPED_AMPERSAND = "~and~";
  *
  * @returns The URL with the path converted to a query string, and the original query string escaped.
  */
-export function convertUrlToQueryStringPath(url: URL, basePathSegments: number = 0): URL {
+export function encodeUrlPathAsQueryString(url: URL, basePathSegments: number = 0): URL {
   const pathSegments = url.pathname.split("/");
   const basePath = pathSegments.slice(0, basePathSegments + 1).join("/");
   const remainingPath = pathSegments.slice(basePathSegments + 1).join("/");
@@ -39,10 +39,6 @@ export function convertUrlToQueryStringPath(url: URL, basePathSegments: number =
   return new URL(newUrl);
 }
 
-export function isQueryStringPath(url: URL): boolean {
-  return url.search !== "" && url.search.startsWith("?/");
-}
-
 /**
  * Converts a query string back into a complete URL. Used in combination with `convertUrlToQueryStringPath()`.
  * to redirect the browser for single-page apps when the server cannot be configured, e.g. GitHub pages.
@@ -51,7 +47,7 @@ export function isQueryStringPath(url: URL): boolean {
  * @param url - The URL with a path converted to a query string, and the original query string escaped.
  * @returns The original URL, with path instead of a query string.
  */
-export function convertQueryStringPathToUrl(url: URL): URL {
+export function decodeUrlQueryStringPath(url: URL): URL {
   if (!url.search || !url.search.startsWith("?/")) {
     return url;
   }
@@ -64,3 +60,51 @@ export function convertQueryStringPathToUrl(url: URL): URL {
 
   return new URL(`${url.origin}${url.pathname}${newPathAndQueryString}${url.hash}`);
 }
+
+export function isEncodedPathUrl(url: URL): boolean {
+  return url.search !== "" && url.search.startsWith("?/");
+}
+
+/**
+ * Encodes a URL for GitHub pages by converting the path to a query string.
+ * See `encodeUrlPathAsQueryString()` for more details.
+ */
+export function encodeGitHubPagesUrl(url: URL): URL {
+  url = new URL(url); // Clone the URL to avoid modifying the original
+  if (url.hostname === "allen-cell-animated.github.io") {
+    if (url.pathname.toString().includes("pr-preview")) {
+      return encodeUrlPathAsQueryString(url, 3);
+    }
+    // Redirect `/main` paths back to root `/`
+    if (url.pathname.toString().includes("main")) {
+      url.pathname = url.pathname.replace("/main", "");
+    }
+    return encodeUrlPathAsQueryString(url, 1);
+  }
+
+  return url;
+}
+
+/**
+ * Decodes a URL that was encoded for GitHub pages, e.g. by `encodeGitHubPagesUrl()`.
+ * See `decodeUrlQueryStringPath()` for more details.
+ */
+export function decodeGitHubPagesUrl(url: URL): URL {
+  return decodeUrlQueryStringPath(url);
+}
+
+/**
+ * Changes URLs with hash-based routing to path-based routing by removing the hash from
+ * the URL. Does nothing to URLs that do not use hash-based routing.
+ */
+export function tryRemoveHashRouting(url: URL): URL {
+  // Remove #/ from the URL path
+  if (url.hash.startsWith("#/")) {
+    const hashContents = url.hash.slice(2);
+    const [path, queryParams] = hashContents.split("?");
+    url.pathname += path;
+    url.search = queryParams ? `?${queryParams}` : "";
+    url.hash = "";
+  }
+  return url;
+}