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indication_paths.yaml
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- directed: true
graph:
disease: CML (ph+)
disease_mesh: MESH:D015464
drug: imatinib
drug_mesh: MESH:D000068877
drugbank: DB00619
links:
- key: INHIBITS
source: MESH:D000068877
target: UniProt:P00519
- key: CAUSES
source: UniProt:P00519
target: MESH:D015464
multigraph: true
nodes:
- id: MESH:D000068877
label: Drug
name: imatinib
- id: UniProt:P00519
label: Protein
name: BCR/ABL
- id: MESH:D015464
label: Disease
name: CML (ph+)
- directed: true
graph:
disease: Systemic mast cell disease
disease_mesh: MESH:D034721
drug: imatinib
drug_mesh: MESH:D000068877
drugbank: DB00619
links:
- key: INHIBITS
source: MESH:D000068877
target: UniProt:P10721
- key: UP_REGULATES
source: UniProt:P10721
target: GO:0008283
- key: CAUSES
source: GO:0008283
target: MESH:D034721
multigraph: true
nodes:
- id: MESH:D000068877
label: Drug
name: imatinib
- id: UniProt:P10721
label: Protein
name: c-Kit
- id: GO:0008283
label: Biological Process
name: Cellular proliferation
- id: MESH:D034721
label: Disease
name: Systemic mast cell disease
- directed: true
graph:
disease: Systemic mast cell disease
disease_mesh: MESH:D034721
drug: imatinib
drug_mesh: MESH:D000068877
drugbank: DB00619
links:
- key: INHIBITS
source: MESH:D000068877
target: UniProt:P16234
- key: UP_REGULATES
source: UniProt:P16234
target: GO:0008283
- key: CAUSES
source: GO:0008283
target: MESH:D034721
multigraph: true
nodes:
- id: MESH:D000068877
label: Drug
name: imatinib
- id: UniProt:P16234
label: Protein
name: Pdgf
- id: GO:0008283
label: Biological Process
name: Cellular proliferation
- id: MESH:D034721
label: Disease
name: Systemic mast cell disease
- directed: true
graph:
disease: Pain
disease_mesh: MESH:D010146
drug: acetaminophen
drug_mesh: MESH:D000082
drugbank: DB00316
links:
- key: INHIBITS
source: MESH:D000082
target: REACT:R-HSA-2162123
- key: ASSOCIATED_WITH
source: REACT:R-HSA-2162123
target: MESH:D010146
multigraph: true
nodes:
- id: MESH:D000082
label: Drug
name: acetaminophen
- id: REACT:R-HSA-2162123
label: Pathway
name: cycloxygenaze pathways
- id: MESH:D010146
label: Disease
name: Pain
- directed: true
graph:
disease: Pain
disease_mesh: MESH:D010146
drug: acetaminophen
drug_mesh: MESH:D000082
drugbank: DB00316
links:
- key: INHIBITS
source: MESH:D000082
target: UniProt:P23219
- key: PRODUCES
source: UniProt:P23219
target: MESH:D011453
- key: CAUSES
source: MESH:D011453
target: MESH:D010146
multigraph: true
nodes:
- id: MESH:D000082
label: Drug
name: acetaminophen
- id: UniProt:P23219
label: Protein
name: Cox-1
- id: MESH:D011453
label: Compound Class
name: Prostaglandins
- id: MESH:D010146
label: Disease
name: Pain
- directed: true
graph:
disease: Pain
disease_mesh: MESH:D010146
drug: acetaminophen
drug_mesh: MESH:D000082
drugbank: DB00316
links:
- key: INHIBITS
source: MESH:D000082
target: UniProt:P35354
- key: PRODUCES
source: UniProt:P35354
target: MESH:D011453
- key: CAUSES
source: MESH:D011453
target: MESH:D010146
multigraph: true
nodes:
- id: MESH:D000082
label: Drug
name: acetaminophen
- id: UniProt:P35354
label: Protein
name: Cox-2
- id: MESH:D011453
label: Compound Class
name: Prostaglandins
- id: MESH:D010146
label: Disease
name: Pain
- directed: true
graph:
disease: Fever
disease_mesh: MESH:D005334
drug: acetaminophen
drug_mesh: MESH:D000082
drugbank: DB00316
links:
- key: INHIBITS
source: MESH:D000082
target: REACT:R-HSA-2162123
- key: LOCALIZED_TO
source: REACT:R-HSA-2162123
target: UBERON:0000955
- key: REGULATES
source: UBERON:0000955
target: GO:0001659
- key: DISRUPTED_IN
source: GO:0001659
target: MESH:D005334
multigraph: true
nodes:
- id: MESH:D000082
label: Drug
name: acetaminophen
- id: REACT:R-HSA-2162123
label: Pathway
name: cycloxygenaze pathways
- id: UBERON:0000955
label: Anatomy
name: Brain
- id: GO:0001659
label: Biological Process
name: Temperature Homeostasis
- id: MESH:D005334
label: Disease
name: Fever
- directed: true
graph:
disease: Pain
disease_mesh: MESH:D010146
drug: acetylsalicylic acid
drug_mesh: MESH:D001241
drugbank: DB00945
links:
- key: INHIBITS
source: MESH:D001241
target: UniProt:P23219
- key: PRODUCES
source: UniProt:P23219
target: MESH:D011453
- key: CAUSES
source: MESH:D011453
target: MESH:D010146
multigraph: true
nodes:
- id: MESH:D001241
label: Drug
name: acetylsalicylic acid
- id: UniProt:P23219
label: Protein
name: Cox-1
- id: MESH:D011453
label: Compound Class
name: Prostaglandins
- id: MESH:D010146
label: Disease
name: Pain
- directed: true
graph:
disease: Pain
disease_mesh: MESH:D010146
drug: acetylsalicylic acid
drug_mesh: MESH:D001241
drugbank: DB00945
links:
- key: INHIBITS
source: MESH:D001241
target: UniProt:P35354
- key: PRODUCES
source: UniProt:P35354
target: MESH:D011453
- key: CAUSES
source: MESH:D011453
target: MESH:D010146
multigraph: true
nodes:
- id: MESH:D001241
label: Drug
name: acetylsalicylic acid
- id: UniProt:P35354
label: Protein
name: Cox-2
- id: MESH:D011453
label: Compound Class
name: Prostaglandins
- id: MESH:D010146
label: Disease
name: Pain
- directed: true
graph:
disease: Thrombosis
disease_mesh: MESH:D013927
drug: acetylsalicylic acid
drug_mesh: MESH:D001241
drugbank: DB00945
links:
- key: INHIBITS
source: MESH:D001241
target: UniProt:P23219
- key: PART_OF
source: UniProt:P23219
target: REACT:R-HSA-2162123
- key: PRODUCES
source: REACT:R-HSA-2162123
target: MESH:D013928
- key: PART_OF
source: MESH:D013928
target: GO:0007596
- key: CAUSES
source: GO:0007596
target: MESH:D013927
multigraph: true
nodes:
- id: MESH:D001241
label: Drug
name: acetylsalicylic acid
- id: UniProt:P23219
label: Protein
name: COX
- id: REACT:R-HSA-2162123
label: Pathway
name: Synthesis of Prostaglandins and Thromboxanes
- id: MESH:D013928
label: Compound
name: Thromboxane A2
- id: GO:0007596
label: Biological Process
name: Platelet Activiation / Blood Coagulation
- id: MESH:D013927
label: Disease
name: Thrombosis
- directed: true
graph:
disease: Thrombosis
disease_mesh: MESH:D013927
drug: acetylsalicylic acid
drug_mesh: MESH:D001241
drugbank: DB00945
links:
- key: INHIBITS
source: MESH:D001241
target: UniProt:P23219
- key: INVOLVED_IN
source: UniProt:P23219
target: GO:0007596
- key: CAUSES
source: GO:0007596
target: MESH:D013927
multigraph: true
nodes:
- id: MESH:D001241
label: Drug
name: acetylsalicylic acid
- id: UniProt:P23219
label: Protein
name: COX
- id: GO:0007596
label: Biological Process
name: Blood Coagulation
- id: MESH:D013927
label: Disease
name: Thrombosis
- directed: true
graph:
disease: Pain
disease_mesh: MESH:D010146
drug: naproxen
drug_mesh: MESH:D009288
drugbank: DB00788
links:
- key: INHIBITS
source: MESH:D009288
target: UniProt:P35354
- key: PRODUCES
source: UniProt:P35354
target: MESH:D011453
- key: PART_OF
source: MESH:D011453
target: GO:0006954
- key: CAUSES
source: GO:0006954
target: MESH:D010146
multigraph: true
nodes:
- id: MESH:D009288
label: Drug
name: naproxen
- id: UniProt:P35354
label: Protein
name: Cox-2
- id: MESH:D011453
label: Compound Class
name: Prostaglandins
- id: GO:0006954
label: Biological Process
name: Inflammation
- id: MESH:D010146
label: Disease
name: Pain
- directed: true
graph:
disease: Shigellosis
disease_mesh: MESH:D004405
drug: norfloxacin
drug_mesh: MESH:D009643
drugbank: DB01059
links:
- key: INHIBITS
source: MESH:D009643
target: UniProt:P43702
- key: INVOLVED_IN
source: UniProt:P43702
target: GO:0006260
- key: REQUIRED_FOR
source: GO:0006260
target: NCBITaxon:622
- key: CAUSES
source: NCBITaxon:622
target: MESH:D004405
multigraph: true
nodes:
- id: MESH:D009643
label: Drug
name: norfloxacin
- id: UniProt:P43702
label: Protein
name: topoisomerases II, IV
- id: GO:0006260
label: Biological Process
name: Bactierial DNA Replication
- id: NCBITaxon:622
label: Taxon
name: Shigella dysenteriae
- id: MESH:D004405
label: Disease
name: Shigellosis
- directed: true
graph:
disease: Shigellosis
disease_mesh: MESH:D004405
drug: norfloxacin
drug_mesh: MESH:D009643
drugbank: DB01059
links:
- key: INHIBITS
source: MESH:D009643
target: GO:0003746
- key: REQUIRED_FOR
source: GO:0003746
target: GO:0006412
- key: REQUIRED_FOR
source: GO:0006412
target: NCBITaxon:622
- key: CAUSES
source: NCBITaxon:622
target: MESH:D004405
multigraph: true
nodes:
- id: MESH:D009643
label: Drug
name: norfloxacin
- id: GO:0003746
label: Molecular Function
name: Translocation of EF-G
- id: GO:0006412
label: Biological Process
name: Bacterial Protein Synthesis
- id: NCBITaxon:622
label: Taxon
name: Shigella dysenteriae
- id: MESH:D004405
label: Disease
name: Shigellosis
- directed: true
graph:
disease: Keratitis
disease_mesh: MESH:D007634
drug: cortisone acetate
drug_mesh: MESH:D003348
drugbank: DB01380
links:
- key: INCREASES_EXPRESSION
source: MESH:D003348
target: UniProt:P04083
- key: DOWN_REGULATES
source: UniProt:P04083
target: REACT:R-HSA-2162123
- key: INVOLVED_IN
source: REACT:R-HSA-2162123
target: GO:0006954
- key: CAUSES
source: GO:0006954
target: MESH:D007634
multigraph: true
nodes:
- id: MESH:D003348
label: Drug
name: cortisone acetate
- id: UniProt:P04083
label: Protein
name: lipocortin-1
- id: REACT:R-HSA-2162123
label: Pathway
name: Prostaglandin Synthesis
- id: GO:0006954
label: Biological Process
name: Inflammation
- id: MESH:D007634
label: Disease
name: Keratitis
- directed: true
graph:
disease: Keratitis
disease_mesh: MESH:D007634
drug: cortisone acetate
drug_mesh: MESH:D003348
drugbank: DB01380
links:
- key: DECREASES_EXPRESSION
source: MESH:D003348
target: UniProt:P23219
- key: PRODUCES
source: UniProt:P23219
target: MESH:D011453
- key: PART_OF
source: MESH:D011453
target: GO:0006954
- key: CAUSES
source: GO:0006954
target: MESH:D007634
multigraph: true
nodes:
- id: MESH:D003348
label: Drug
name: cortisone acetate
- id: UniProt:P23219
label: Protein
name: COX Genes
- id: MESH:D011453
label: Compound Class
name: Prostaglandins
- id: GO:0006954
label: Biological Process
name: Inflammation
- id: MESH:D007634
label: Disease
name: Keratitis
- directed: true
graph:
disease: Keratitis
disease_mesh: MESH:D007634
drug: cortisone acetate
drug_mesh: MESH:D003348
drugbank: DB01380
links:
- key: INCREASES_EXPRESSION
source: MESH:D003348
target: UniProt:P04083
- key: DOWN_REGULATES
source: UniProt:P04083
target: GO:0050900
- key: UP_REGULATES
source: GO:0050900
target: GO:0006954
- key: CAUSES
source: GO:0006954
target: MESH:D007634
multigraph: true
nodes:
- id: MESH:D003348
label: Drug
name: cortisone acetate
- id: UniProt:P04083
label: Protein
name: lipocortin-1
- id: GO:0050900
label: Biological Process
name: Immune Cell Funciton
- id: GO:0006954
label: Biological Process
name: Inflammation
- id: MESH:D007634
label: Disease
name: Keratitis
- directed: true
graph:
disease: Keratitis
disease_mesh: MESH:D007634
drug: cortisone acetate
drug_mesh: MESH:D003348
drugbank: DB01380
links:
- key: ACTIVATES
source: MESH:D003348
target: UniProt:P04150
- key: UP_REGULATES
source: UniProt:P04150
target: UniProt:P04083
- key: DOWN_REGULATES
source: UniProt:P04083
target: REACT:R-HSA-2162123
- key: UP_REGULATES
source: REACT:R-HSA-2162123
target: GO:0006954
- key: CAUSES
source: GO:0006954
target: MESH:D007634
multigraph: true
nodes:
- id: MESH:D003348
label: Drug
name: cortisone acetate
- id: UniProt:P04150
label: Protein
name: Glucocorticoid receptor
- id: UniProt:P04083
label: Protein
name: Annexin A1
- id: REACT:R-HSA-2162123
label: Pathway
name: Prostaglandin Synthesis
- id: GO:0006954
label: Biological Process
name: Inflammation
- id: MESH:D007634
label: Disease
name: Keratitis
- directed: true
graph:
disease: Keratitis
disease_mesh: MESH:D007634
drug: cortisone acetate
drug_mesh: MESH:D003348
drugbank: DB01380
links:
- key: ACTIVATES
source: MESH:D003348
target: UniProt:P04150
- key: DOWN_REGULATES
source: UniProt:P04150
target: UniProt:P23219
- key: PRODUCES
source: UniProt:P23219
target: MESH:D011453
- key: PART_OF
source: MESH:D011453
target: GO:0006954
- key: CAUSES
source: GO:0006954
target: MESH:D007634
multigraph: true
nodes:
- id: MESH:D003348
label: Drug
name: cortisone acetate
- id: UniProt:P04150
label: Protein
name: Glucocorticoid receptor
- id: UniProt:P23219
label: Protein
name: COX genes
- id: MESH:D011453
label: Compound Class
name: Prostaglandins
- id: GO:0006954
label: Biological Process
name: Inflammation
- id: MESH:D007634
label: Disease
name: Keratitis
- directed: true
graph:
disease: CMV infection
disease_mesh: MESH:D003586
drug: valganciclovir
drug_mesh: MESH:D000077562
drugbank: DB01610
links:
- key: INCREASES
source: MESH:D000077562
target: MESH:D015774
- key: DOWN_REGULATES
source: MESH:D015774
target: GO:0039693
- key: REQUIRED_FOR
source: GO:0039693
target: NCBITaxon:10358
- key: CAUSES
source: NCBITaxon:10358
target: MESH:D003586
multigraph: true
nodes:
- id: MESH:D000077562
label: Drug
name: valganciclovir
- id: MESH:D015774
label: Compound
name: ganciclovir
- id: GO:0039693
label: Biological Process
name: viral DNA replication
- id: NCBITaxon:10358
label: Taxon
name: Cytomegalovirus
- id: MESH:D003586
label: Disease
name: CMV infection
- directed: true
graph:
disease: Bacterial septicemia
disease_mesh: MESH:D018805
drug: metronidazole
drug_mesh: MESH:D008795
drugbank: DB00916
links:
- key: INCREASES
source: MESH:D008795
target: MESH:C029371
- key: DOWN_REGULATES
source: MESH:C029371
target: GO:0003676
- key: REQUIRED_FOR
source: GO:0003676
target: NCBITaxon:2
- key: CAUSES
source: NCBITaxon:2
target: MESH:D018805
multigraph: true
nodes:
- id: MESH:D008795
label: Drug
name: metronidazole
- id: MESH:C029371
label: Compound
name: hydroxyethyl oxamic acid
- id: GO:0003676
label: Biological Process
name: bacterial Nucleic Acid synthesis
- id: NCBITaxon:2
label: Taxon
name: Bacteria
- id: MESH:D018805
label: Disease
name: Bacterial septicemia
- directed: true
graph:
disease: Rickettsialpox
disease_mesh: MESH:D000073605
drug: demeclocycline
drug_mesh: MESH:D003707
drugbank: DB00618
links:
- key: INHIBITS
source: MESH:D003707
target: UniProt:P0A7S3
- key: INVOLVED_IN
source: UniProt:P0A7S3
target: GO:0006412
- key: REQUIRED_FOR
source: GO:0006412
target: NCBITaxon:786
- key: CAUSES
source: NCBITaxon:786
target: MESH:D000073605
multigraph: true
nodes:
- id: MESH:D003707
label: Drug
name: demeclocycline
- id: UniProt:P0A7S3
label: Protein
name: 30S Ribosomal Subunit
- id: GO:0006412
label: Biological Process
name: Bacterial Translation
- id: NCBITaxon:786
label: Taxon
name: Rickettsia akari
- id: MESH:D000073605
label: Disease
name: Rickettsialpox
- directed: true
graph:
disease: Rickettsialpox
disease_mesh: MESH:D000073605
drug: demeclocycline
drug_mesh: MESH:D003707
drugbank: DB00618
links:
- key: INHIBITS
source: MESH:D003707
target: UniProt:P0A7J3
- key: INVOLVED_IN
source: UniProt:P0A7J3
target: GO:0006412
- key: REQUIRED_FOR
source: GO:0006412
target: NCBITaxon:786
- key: CAUSES
source: NCBITaxon:786
target: MESH:D000073605
multigraph: true
nodes:
- id: MESH:D003707
label: Drug
name: demeclocycline
- id: UniProt:P0A7J3
label: Protein
name: 50S Ribosomal Subunit
- id: GO:0006412
label: Biological Process
name: Bacterial Translation
- id: NCBITaxon:786
label: Taxon
name: Rickettsia akari
- id: MESH:D000073605
label: Disease
name: Rickettsialpox
- directed: true
graph:
disease: Streptococcal tonsillitis
disease_mesh: MESH:D014069
drug: amoxicillin
drug_mesh: MESH:D000658
drugbank: DB01060
links:
- key: INHIBITS
source: MESH:D000658
target: UniProt:P71707
- key: INVOLVED_IN
source: UniProt:P71707
target: GO:0009252
- key: REQUIRED_FOR
source: GO:0009252
target: NCBITaxon:1314
- key: CAUSES
source: NCBITaxon:1314
target: MESH:D014069
multigraph: true
nodes:
- id: MESH:D000658
label: Drug
name: amoxicillin
- id: UniProt:P71707
label: Protein
name: Penicillin-binding protein 1A
- id: GO:0009252
label: Biological Process
name: Peptidoglycan Biosyntheic Process
- id: NCBITaxon:1314
label: Taxon
name: Streptococcus pyogenes
- id: MESH:D014069
label: Disease
name: Streptococcal tonsillitis
- directed: true
graph:
disease: Staphylococcal pneumonia
disease_mesh: MESH:D011023
drug: alatrofloxacin
drug_mesh: MESH:C106856
drugbank: DB09335
links:
- key: INHIBITS
source: MESH:C106856
target: UniProt:P0C1U9
- key: INVOLVED_IN
source: UniProt:P0C1U9
target: GO:0006260
- key: REQUIRED_FOR
source: GO:0006260
target: NCBITaxon:1280
- key: CAUSES
source: NCBITaxon:1280
target: MESH:D011023
multigraph: true
nodes:
- id: MESH:C106856
label: Drug
name: alatrofloxacin
- id: UniProt:P0C1U9
label: Protein
name: Topoisomeraze 4
- id: GO:0006260
label: Biological Process
name: Bacterial DNA replication
- id: NCBITaxon:1280
label: Taxon
name: Staphylococcus aureus
- id: MESH:D011023
label: Disease
name: Staphylococcal pneumonia
- directed: true
graph:
disease: Staphylococcal pneumonia
disease_mesh: MESH:D011023
drug: alatrofloxacin
drug_mesh: MESH:C106856
drugbank: DB09335
links:
- key: INHIBITS
source: MESH:C106856
target: UniProt:P20831
- key: INVOLVED_IN
source: UniProt:P20831
target: GO:0006260
- key: REQUIRED_FOR
source: GO:0006260
target: NCBITaxon:1280
- key: CAUSES
source: NCBITaxon:1280
target: MESH:D011023
multigraph: true
nodes:
- id: MESH:C106856
label: Drug
name: alatrofloxacin
- id: UniProt:P20831
label: Protein
name: DNA gyrase
- id: GO:0006260
label: Biological Process
name: Bacterial DNA replication
- id: NCBITaxon:1280
label: Taxon
name: Staphylococcus aureus
- id: MESH:D011023
label: Disease
name: Staphylococcal pneumonia
- directed: true
graph:
disease: Bacterial meningitis
disease_mesh: MESH:D016920
drug: amikacin
drug_mesh: MESH:D000583
drugbank: DB00479
links:
- key: INHIBITS
source: MESH:D000583
target: UniProt:P0A7S3
- key: INVOLVED_IN
source: UniProt:P0A7S3
target: GO:0006412
- key: REQUIRED_FOR
source: GO:0006412
target: NCBITaxon:2
- key: CAUSES
source: NCBITaxon:2
target: MESH:D016920
multigraph: true
nodes:
- id: MESH:D000583
label: Drug
name: amikacin
- id: UniProt:P0A7S3
label: Protein
name: 30S Ribosomal Subunit
- id: GO:0006412
label: Biological Process
name: Bacterial Translation
- id: NCBITaxon:2
label: Taxon
name: Bacteria
- id: MESH:D016920
label: Disease
name: Bacterial meningitis
- directed: true
graph:
disease: Tenosynovitis
disease_mesh: MESH:D013717
drug: dexamethasone
drug_mesh: MESH:D003907
drugbank: DB01234
links:
- key: ACTIVATES
source: MESH:D003907
target: UniProt:P04150
- key: UP_REGULATES
source: UniProt:P04150
target: UniProt:P04083
- key: DOWN_REGULATES
source: UniProt:P04083
target: REACT:R-HSA-2162123
- key: UP_REGULATES
source: REACT:R-HSA-2162123
target: GO:0006954
- key: CAUSES
source: GO:0006954
target: MESH:D013717
multigraph: true
nodes:
- id: MESH:D003907
label: Drug
name: dexamethasone
- id: UniProt:P04150
label: Protein
name: Glucocorticoid receptor
- id: UniProt:P04083
label: Protein
name: Annexin A1
- id: REACT:R-HSA-2162123
label: Pathway
name: Prostaglandin Synthesis
- id: GO:0006954
label: Biological Process
name: Inflammation
- id: MESH:D013717
label: Disease
name: Tenosynovitis
- directed: true
graph:
disease: Bacterial urinary infection
disease_mesh: MESH:D014552
drug: ceftazidime
drug_mesh: MESH:D002442