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phrasing and reference
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slobentanzer committed Jan 15, 2024
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Expand Up @@ -7,7 +7,7 @@ In addition, biological events are context-dependent, for instance with respect

Large Language Models (LLMs) of the current generation, on the other hand, can access enormous amounts of knowledge, encoded (incomprehensibly) in their billions of parameters [@doi:10.48550/arxiv.2204.02311;@doi:10.48550/arxiv.2201.08239;@doi:10.48550/arxiv.2303.08774].
Trained correctly, they can recall and combine virtually limitless knowledge from their training set.
ChatGPT has taken the world by storm, and many biomedical researchers already use LLMs in their daily work, for general as well as bioinformatics-specific tasks [@doi:10.1101/2023.04.16.537094;@doi:10.1038/s41587-023-01789-6].
ChatGPT has taken the world by storm, and many biomedical researchers already use LLMs in their daily work, for general as well as research tasks [@doi:10.1038/s41586-023-06792-0;@doi:10.1101/2023.04.16.537094;@doi:10.1038/s41587-023-01789-6].
However, the current, predominantly manual, way of interacting with LLMs is virtually non-reproducible, and their behaviour can be erratic.
For instance, they are known to confabulate: they make up facts as they go along, and, to make matters worse, are convinced - and convincing - regarding the truth of their confabulations [@doi:10.1038/s41586-023-05881-4;@doi:10.1038/s41587-023-01789-6].
While current efforts towards Artificial General Intelligence manage to ameliorate some of the shortcomings by ensembling multiple models [@{https://python.langchain.com}] with long-term memory stores [@{https://autogpt.net/}], the current generation of AI does not inspire adequate trust to be applied to biomedical problems without supervision [@doi:10.1038/s41586-023-05881-4].
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