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main.tex
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\documentclass[nohyper,nobib]{tufte-book}
\usepackage{nameref}
% \hypersetup{colorlinks}
\usepackage{hyphenat}
\usepackage{url}
\usepackage{amsmath}
\usepackage[backend=biber, natbib=true, style=numeric]{biblatex}
\addbibresource{main.bib}
\usepackage{xargs}
\renewcommandx{\cite}[3][1={0pt},2={}]{\sidenote[][#1]{\fullcite[#2]{#3}}}
\title{Introduction to \\ Bioinformatics}
\date{First Edition}
\author[Bla\v{z} Zupan and Toma\v{z} Curk]{B. Zupan and T. Curk}
\publisher{University of Ljubljana}
%%
% If they're installed, use Bergamo and Chantilly from www.fontsite.com.
% They're clones of Bembo and Gill Sans, respectively.
%\IfFileExists{bergamo.sty}{\usepackage[osf]{bergamo}}{}% Bembo
%\IfFileExists{chantill.sty}{\usepackage{chantill}}{}% Gill Sans
%\usepackage{microtype}
\usepackage{lipsum} %todo sample text, remove when ready
\usepackage{booktabs} % For nicely typeset tabular material
\usepackage{graphicx}
\setkeys{Gin}{width=\linewidth,totalheight=\textheight,keepaspectratio}
\graphicspath{{graphics/}}
% The fancyvrb package lets us customize the formatting of verbatim
% environments. We use a slightly smaller font.
\usepackage{fancyvrb}
\fvset{fontsize=\normalsize}
%%
% Prints argument within hanging parentheses (i.e., parentheses that take
% up no horizontal space). Useful in tabular environments.
\newcommand{\hangp}[1]{\makebox[0pt][r]{(}#1\makebox[0pt][l]{)}}
%%
% Prints an asterisk that takes up no horizontal space.
% Useful in tabular environments.
\newcommand{\hangstar}{\makebox[0pt][l]{*}}
%%
% Prints a trailing space in a smart way.
\usepackage{xspace}
% Some shortcuts for Tufte's book titles. The lowercase commands will
% produce the initials of the book title in italics. The all-caps commands
% will print out the full title of the book in italics.
% todo: remove
\newcommand{\vdqi}{\textit{VDQI}\xspace}
\newcommand{\ei}{\textit{EI}\xspace}
\newcommand{\ve}{\textit{VE}\xspace}
\newcommand{\be}{\textit{BE}\xspace}
\newcommand{\VDQI}{\textit{The Visual Display of Quantitative Information}\xspace}
\newcommand{\EI}{\textit{Envisioning Information}\xspace}
\newcommand{\VE}{\textit{Visual Explanations}\xspace}
\newcommand{\BE}{\textit{Beautiful Evidence}\xspace}
\newcommand{\TL}{Tufte-\LaTeX\xspace}
% Prints the month name (e.g., January) and the year (e.g., 2008)
\newcommand{\monthyear}{%
\ifcase\month\or January\or February\or March\or April\or May\or June\or
July\or August\or September\or October\or November\or
December\fi\space\number\year
}
% Prints an epigraph and speaker in sans serif, all-caps type.
\newcommand{\openepigraph}[2]{%
%\sffamily\fontsize{14}{16}\selectfont
\begin{fullwidth}
\sffamily\large
\begin{doublespace}
\noindent\allcaps{#1}\\% epigraph
\noindent\allcaps{#2}% author
\end{doublespace}
\end{fullwidth}
}
% Inserts a blank page
\newcommand{\blankpage}{\newpage\hbox{}\thispagestyle{empty}\newpage}
\usepackage{units}
% Typesets the font size, leading, and measure in the form of 10/12x26 pc.
\newcommand{\measure}[3]{#1/#2$\times$\unit[#3]{pc}}
% Macros for typesetting the documentation
\newcommand{\hlred}[1]{\textcolor{Maroon}{#1}}% prints in red
\newcommand{\hangleft}[1]{\makebox[0pt][r]{#1}}
\newcommand{\hairsp}{\hspace{1pt}}% hair space
\newcommand{\hquad}{\hskip0.5em\relax}% half quad space
\newcommand{\TODO}{\textcolor{red}{\bf TODO!}\xspace}
\newcommand{\ie}{\textit{i.\hairsp{}e.}\xspace}
\newcommand{\eg}{\textit{e.\hairsp{}g.}\xspace}
\newcommand{\na}{\quad--}% used in tables for N/A cells
\providecommand{\XeLaTeX}{X\lower.5ex\hbox{\kern-0.15em\reflectbox{E}}\kern-0.1em\LaTeX}
\newcommand{\tXeLaTeX}{\XeLaTeX\index{XeLaTeX@\protect\XeLaTeX}}
% \index{\texttt{\textbackslash xyz}@\hangleft{\texttt{\textbackslash}}\texttt{xyz}}
\newcommand{\tuftebs}{\symbol{'134}}% a backslash in tt type in OT1/T1
\newcommand{\doccmdnoindex}[2][]{\texttt{\tuftebs#2}}% command name -- adds backslash automatically (and doesn't add cmd to the index)
\newcommand{\doccmddef}[2][]{%
\hlred{\texttt{\tuftebs#2}}\label{cmd:#2}%
\ifthenelse{\isempty{#1}}%
{% add the command to the index
\index{#2 command@\protect\hangleft{\texttt{\tuftebs}}\texttt{#2}}% command name
}%
{% add the command and package to the index
\index{#2 command@\protect\hangleft{\texttt{\tuftebs}}\texttt{#2} (\texttt{#1} package)}% command name
\index{#1 package@\texttt{#1} package}\index{packages!#1@\texttt{#1}}% package name
}%
}% command name -- adds backslash automatically
\newcommand{\doccmd}[2][]{%
\texttt{\tuftebs#2}%
\ifthenelse{\isempty{#1}}%
{% add the command to the index
\index{#2 command@\protect\hangleft{\texttt{\tuftebs}}\texttt{#2}}% command name
}%
{% add the command and package to the index
\index{#2 command@\protect\hangleft{\texttt{\tuftebs}}\texttt{#2} (\texttt{#1} package)}% command name
\index{#1 package@\texttt{#1} package}\index{packages!#1@\texttt{#1}}% package name
}%
}% command name -- adds backslash automatically
\newcommand{\docopt}[1]{\ensuremath{\langle}\textrm{\textit{#1}}\ensuremath{\rangle}}% optional command argument
\newcommand{\docarg}[1]{\textrm{\textit{#1}}}% (required) command argument
\newenvironment{docspec}{\begin{quotation}\ttfamily\parskip0pt\parindent0pt\ignorespaces}{\end{quotation}}% command specification environment
\newcommand{\docenv}[1]{\texttt{#1}\index{#1 environment@\texttt{#1} environment}\index{environments!#1@\texttt{#1}}}% environment name
\newcommand{\docenvdef}[1]{\hlred{\texttt{#1}}\label{env:#1}\index{#1 environment@\texttt{#1} environment}\index{environments!#1@\texttt{#1}}}% environment name
\newcommand{\docpkg}[1]{\texttt{#1}\index{#1 package@\texttt{#1} package}\index{packages!#1@\texttt{#1}}}% package name
\newcommand{\doccls}[1]{\texttt{#1}}% document class name
\newcommand{\docclsopt}[1]{\texttt{#1}\index{#1 class option@\texttt{#1} class option}\index{class options!#1@\texttt{#1}}}% document class option name
\newcommand{\docclsoptdef}[1]{\hlred{\texttt{#1}}\label{clsopt:#1}\index{#1 class option@\texttt{#1} class option}\index{class options!#1@\texttt{#1}}}% document class option name defined
\newcommand{\docmsg}[2]{\bigskip\begin{fullwidth}\noindent\ttfamily#1\end{fullwidth}\medskip\par\noindent#2}
\newcommand{\docfilehook}[2]{\texttt{#1}\index{file hooks!#2}\index{#1@\texttt{#1}}}
\newcommand{\doccounter}[1]{\texttt{#1}\index{#1 counter@\texttt{#1} counter}}
% Generates the index
\usepackage{makeidx}
\makeindex
%%%% Kevin Godny's code for title page and contents from https://groups.google.com/forum/#!topic/tufte-latex/ujdzrktC1BQ
\makeatletter
\renewcommand{\maketitlepage}{%
\begingroup%
\setlength{\parindent}{0pt}
{\fontsize{24}{24}\selectfont\textit{\@author}\par}
\vspace{1.75in}{\fontsize{36}{54}\selectfont\@title\par}
\vspace{0.5in}{\fontsize{14}{14}\selectfont\textsf{\smallcaps{\@date}}\par}
\vfill{\fontsize{14}{14}\selectfont\textit{\@publisher}\par}
\thispagestyle{empty}
\endgroup
}
\makeatother
\titlecontents{part}%
[0pt]% distance from left margin
{\addvspace{0.25\baselineskip}}% above (global formatting of entry)
{\allcaps{Part~\thecontentslabel}\allcaps}% before w/ label (label = ``Part I'')
{\allcaps{Part~\thecontentslabel}\allcaps}% before w/o label
{}% filler and page (leaders and page num)
[\vspace*{0.5\baselineskip}]% after
\titlecontents{chapter}%
[4em]% distance from left margin
{}% above (global formatting of entry)
{\contentslabel{2em}\textit}% before w/ label (label = ``Chapter 1'')
{\hspace{0em}\textit}% before w/o label
{\qquad\thecontentspage}% filler and page (leaders and page num)
[\vspace*{0.5\baselineskip}]% after
%%%% End additional code by Kevin Godby
\usepackage{listings}
\lstset{
language=Python,
basicstyle=\ttfamily\small, % Code font style
keywordstyle=\color{blue}\bfseries, % Keywords in blue
commentstyle=\color{gray}, % Comments in gray
stringstyle=\color{red}, % Strings in red
frame=lines, % Adds frame around the code
numbers=none, % No line numbers
showstringspaces=false, % Don't show spaces in strings
backgroundcolor=\color{white}, % White background (default)
}
\usepackage{multirow}
\usepackage{array}
\begin{document}
% Front matter
\frontmatter
% r.3 full title page
\maketitle
% v.4 copyright page
\newpage
\begin{fullwidth}
~\vfill
\thispagestyle{empty}
\setlength{\parindent}{0pt}
\setlength{\parskip}{\baselineskip}
Copyright \copyright\ \the\year\ \thanklessauthor
\par\smallcaps{Published by \thanklesspublisher}
\par This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
\par\textit{Draft Edition, \monthyear}
\end{fullwidth}
% r.5 contents
\tableofcontents
% r.9 introduction
\cleardoublepage
\chapter*{Introduction}
This book, {\em Introduction to Bioinformatics}, is designed for computer scientists who want a practical, data-driven approach to understanding biological data. It assumes no prior knowledge of biology, but does require a basic understanding of algorithms, computational thinking, and some familiarity with Python programming. The goal is to provide a gradual learning curve that introduces bioinformatics concepts in a way that is both accessible and focused on computational methods.
In recent years, biotechnology has advanced to the point where laboratories worldwide are able to collect vast amounts of molecular data. Coupled with the wealth of data already available online and numerous annotated datasets, computational approaches have become essential. Today, almost all biological research relies heavily on data, and the sheer volume requires experts skilled in data science.
In this course, we aim to equip students with the tools and knowledge necessary to address the challenges posed by this influx of biological data. Through the use of algorithms, models and computational strategies, students will be able to derive meaningful insights. As biological research increasingly relies on large-scale data analysis, skills in statistics, data visualization, and machine learning are critical. Statistical methods help extract meaningful patterns from noisy data, while machine learning and artificial intelligence provide powerful techniques for predictive modeling and pattern recognition. Data visualization is key to interpreting complex data sets, allowing scientists to effectively explore trends and relationships. By integrating these approaches, this book and course prepare readers to navigate the computational landscape of modern biology and contribute to cutting-edge bioinformatics research.
%%
% Start the main matter (normal chapters)
\mainmatter
\part{Molecular Biology}
\input{c-molbio.tex}
\input{c-history.tex}
\input{c-genome.tex}
\input{c-genes.tex}
\input{c-alignment.tex}
\backmatter
% \bibliography{main}
% \bibliographystyle{plainnat}
\printindex
\end{document}