From 14d113e47fc3da8333016df556d74391d1b507b0 Mon Sep 17 00:00:00 2001 From: Kori Kuzma Date: Wed, 29 Jan 2025 16:12:59 -0500 Subject: [PATCH] fix!: use correct representation of Coding object in mappings (#457) close #456 * bump disease normalizer version to pull in updated mappings representations * correct `Coding` representation * `system` MUST use `iriReference`, not a free-text label * `code` MUST use syntax defined by the `system` * `id` will use record `concept_id` * Removes `SYSTEM_URI_TO_NAMESPACE` mapping (since it's no longer needed) --- pyproject.toml | 4 +- src/therapy/query.py | 51 +- src/therapy/schemas.py | 73 +- tests/conftest.py | 1 + tests/data/fixtures/query_fixtures.json | 1080 ++++++++++++++--------- 5 files changed, 713 insertions(+), 496 deletions(-) diff --git a/pyproject.toml b/pyproject.toml index 1fb454af..48b8ccbd 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -30,13 +30,13 @@ dependencies = [ "click", "boto3", "ga4gh.vrs==2.0.0a13", - "disease-normalizer~=0.7.0", + "disease-normalizer~=0.8.0", ] dynamic = ["version"] [project.optional-dependencies] etl = [ - "disease-normalizer[etl]~=0.7.0", + #"disease-normalizer[etl]~=0.7.0", "owlready2", "rdflib", "wikibaseintegrator>=0.12.0", diff --git a/src/therapy/query.py b/src/therapy/query.py index 51362dcd..76e7b988 100644 --- a/src/therapy/query.py +++ b/src/therapy/query.py @@ -7,8 +7,7 @@ from typing import Any, TypeVar from botocore.exceptions import ClientError -from disease.schemas import NAMESPACE_TO_SYSTEM_URI as DISEASE_NAMESPACE_TO_SYSTEM_URI -from disease.schemas import NamespacePrefix as DiseaseNamespacePrefix +from disease.query import get_concept_mapping as get_disease_concept_mapping from ga4gh.core.models import ( Coding, ConceptMapping, @@ -23,7 +22,6 @@ from therapy.database import AbstractDatabase from therapy.schemas import ( NAMESPACE_TO_SYSTEM_URI, - SYSTEM_URI_TO_NAMESPACE, BaseNormalizationService, HasIndication, MatchesNormalized, @@ -365,7 +363,7 @@ def _add_merged_meta(self, response: NormalizationService) -> NormalizationServi sources = [] for m in therapy.mappings or []: - ns = SYSTEM_URI_TO_NAMESPACE.get(m.coding.system) + ns = m.coding.id.split(":")[0] if ns in PREFIX_LOOKUP: sources.append(PREFIX_LOOKUP[ns]) @@ -399,39 +397,42 @@ def _add_therapy( :return: completed response object ready to return to user """ - def _create_concept_mapping( + def _get_concept_mapping( concept_id: str, relation: Relation, - ns_to_system_uri: dict[str, str], - ns_prefix: NamespacePrefix | DiseaseNamespacePrefix, ) -> ConceptMapping: - """Create concept mapping for therapy or disease identifier + """Create concept mapping for identifier - ``system`` will use OBO Foundry persistent URL (PURL), source homepage, or - namespace prefix, in that order of preference, if available. + ``system`` will use system prefix URL, OBO Foundry persistent URL (PURL), or + source homepage, in that order of preference. :param concept_id: Concept identifier represented as a curie :param relation: SKOS mapping relationship, default is relatedMatch - :param ns_to_system_uri: Dictionary containing mapping from namespace to - system URI - :param ns_prefix: Namespace prefix enum - :return: Concept mapping for therapy or disease identifier + :raises ValueError: If source of concept ID is not a valid + ``NamespacePrefix`` + :return: Concept mapping for identifier """ - source = concept_id.split(":")[0] + source, source_code = concept_id.split(":") try: - source = ns_prefix(source) + source = NamespacePrefix(source) except ValueError: try: - source = ns_prefix(source.upper()) + source = NamespacePrefix(source.upper()) except ValueError as e: err_msg = f"Namespace prefix not supported: {source}" raise ValueError(err_msg) from e - system = ns_to_system_uri.get(source, source) + if source == NamespacePrefix.CHEBI: + source_code = concept_id return ConceptMapping( - coding=Coding(code=code(concept_id), system=system), relation=relation + coding=Coding( + id=concept_id, + code=code(source_code), + system=NAMESPACE_TO_SYSTEM_URI[source], + ), + relation=relation, ) therapy_obj = MappableConcept( @@ -443,20 +444,16 @@ def _create_concept_mapping( # mappings mappings = [ - _create_concept_mapping( + _get_concept_mapping( concept_id=record["concept_id"], relation=Relation.EXACT_MATCH, - ns_to_system_uri=NAMESPACE_TO_SYSTEM_URI, - ns_prefix=NamespacePrefix, ) ] source_ids = record.get("xrefs", []) + record.get("associated_with", []) mappings.extend( - _create_concept_mapping( + _get_concept_mapping( concept_id=source_id, relation=Relation.RELATED_MATCH, - ns_to_system_uri=NAMESPACE_TO_SYSTEM_URI, - ns_prefix=NamespacePrefix, ) for source_id in source_ids ) @@ -490,11 +487,9 @@ def _create_concept_mapping( if indication.normalized_disease_id: mappings = [ - _create_concept_mapping( + get_disease_concept_mapping( concept_id=indication.normalized_disease_id, relation=Relation.RELATED_MATCH, - ns_to_system_uri=DISEASE_NAMESPACE_TO_SYSTEM_URI, - ns_prefix=DiseaseNamespacePrefix, ) ] else: diff --git a/src/therapy/schemas.py b/src/therapy/schemas.py index 12d2490a..a96fc180 100644 --- a/src/therapy/schemas.py +++ b/src/therapy/schemas.py @@ -2,6 +2,7 @@ from datetime import datetime from enum import Enum, IntEnum +from types import MappingProxyType from typing import Any, Literal from ga4gh.core.models import MappableConcept @@ -258,37 +259,39 @@ class NamespacePrefix(Enum): WIKIDATA = "wikidata" -# Source to URI. Will use OBO Foundry persistent URL (PURL) or source homepage -NAMESPACE_TO_SYSTEM_URI: dict[NamespacePrefix, str] = { - NamespacePrefix.ATC: "https://www.who.int/tools/atc-ddd-toolkit/atc-classification/", - NamespacePrefix.CHEBI: "http://purl.obolibrary.org/obo/chebi.owl", - NamespacePrefix.CHEMBL: "https://www.ebi.ac.uk/chembl/", - NamespacePrefix.CHEMIDPLUS: "https://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus", - NamespacePrefix.CASREGISTRY: "https://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus", - NamespacePrefix.CVX: "https://www2a.cdc.gov/vaccines/iis/iisstandards/vaccines.asp?rpt=cvx", - NamespacePrefix.DRUGBANK: "https://go.drugbank.com", - NamespacePrefix.DRUGCENTRAL: "https://drugcentral.org", - NamespacePrefix.DRUGSATFDA_ANDA: "https://www.fda.gov/drugs/types-applications/abbreviated-new-drug-application-anda", - NamespacePrefix.DRUGSATFDA_NDA: "https://www.fda.gov/drugs/types-applications/new-drug-application-nda", - NamespacePrefix.HEMONC: "https://hemonc.org", - NamespacePrefix.INCHIKEY: "https://www.chemspider.com", - NamespacePrefix.IUPHAR_LIGAND: "https://www.guidetopharmacology.org/GRAC/LigandListForward", - NamespacePrefix.GUIDETOPHARMACOLOGY: "https://www.guidetopharmacology.org/GRAC/LigandListForward", - NamespacePrefix.MMSL: "https://www.nlm.nih.gov/research/umls/rxnorm/sourcereleasedocs/mmsl.html", - NamespacePrefix.MSH: "https://id.nlm.nih.gov/mesh/", - NamespacePrefix.NCIT: "http://purl.obolibrary.org/obo/ncit.owl", - NamespacePrefix.NDC: "https://dps.fda.gov/ndc", - NamespacePrefix.PUBCHEMCOMPOUND: "https://pubchem.ncbi.nlm.nih.gov/docs/compounds", - NamespacePrefix.PUBCHEMSUBSTANCE: "https://pubchem.ncbi.nlm.nih.gov/docs/substances", - NamespacePrefix.RXNORM: "https://www.nlm.nih.gov/research/umls/rxnorm/index.html", - NamespacePrefix.SPL: "https://www.fda.gov/industry/fda-data-standards-advisory-board/structured-product-labeling-resources", - NamespacePrefix.UMLS: "https://www.nlm.nih.gov/research/umls/index.html", - NamespacePrefix.UNII: "https://precision.fda.gov/uniisearch", - NamespacePrefix.UNIPROT: "https://www.uniprot.org", - NamespacePrefix.USP: "https://www.usp.org/health-quality-safety/compendial-nomenclature", - NamespacePrefix.VANDF: "https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/VANDF", - NamespacePrefix.WIKIDATA: "https://www.wikidata.org", -} +# Source to URI. Will use system prefix URL, OBO Foundry persistent URL (PURL) or source homepage +NAMESPACE_TO_SYSTEM_URI: MappingProxyType[NamespacePrefix, str] = MappingProxyType( + { + NamespacePrefix.ATC: "https://atcddd.fhi.no/atc_ddd_index/?code=", + NamespacePrefix.CHEBI: "https://www.ebi.ac.uk/chebi/searchId.do?chebiId=", + NamespacePrefix.CHEMBL: "https://www.ebi.ac.uk/chembl/explore/compound/", + NamespacePrefix.CHEMIDPLUS: "https://commonchemistry.cas.org/detail?cas_rn=", + NamespacePrefix.CASREGISTRY: "https://commonchemistry.cas.org/detail?cas_rn=", + NamespacePrefix.CVX: "https://www2a.cdc.gov/vaccines/iis/iisstandards/vaccines.asp?rpt=cvx", + NamespacePrefix.DRUGBANK: "https://go.drugbank.com/drugs/", + NamespacePrefix.DRUGCENTRAL: "https://drugcentral.org/drugcard/", + NamespacePrefix.DRUGSATFDA_ANDA: "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=", + NamespacePrefix.DRUGSATFDA_NDA: "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=", + NamespacePrefix.HEMONC: "https://hemonc.org", + NamespacePrefix.INCHIKEY: "https://www.chemspider.com", + NamespacePrefix.IUPHAR_LIGAND: "https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=", + NamespacePrefix.GUIDETOPHARMACOLOGY: "https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=", + NamespacePrefix.MMSL: "https://www.nlm.nih.gov/research/umls/rxnorm/sourcereleasedocs/mmsl.html", + NamespacePrefix.MSH: "https://id.nlm.nih.gov/mesh/", + NamespacePrefix.NCIT: "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + NamespacePrefix.NDC: "https://dps.fda.gov/ndc/searchresult?selection=finished_product&content=PRODUCTNDC&type=", + NamespacePrefix.PUBCHEMCOMPOUND: "https://pubchem.ncbi.nlm.nih.gov/compound/", + NamespacePrefix.PUBCHEMSUBSTANCE: "https://pubchem.ncbi.nlm.nih.gov/substance/", + NamespacePrefix.RXNORM: "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=", + NamespacePrefix.SPL: "https://www.fda.gov/industry/fda-data-standards-advisory-board/structured-product-labeling-resources", + NamespacePrefix.UMLS: "https://uts.nlm.nih.gov/uts/umls/concept/", + NamespacePrefix.UNII: "https://precision.fda.gov/uniisearch/srs/unii/", + NamespacePrefix.UNIPROT: "http://purl.uniprot.org/uniprot/", + NamespacePrefix.USP: "https://www.usp.org/health-quality-safety/compendial-nomenclature", + NamespacePrefix.VANDF: "https://www.nlm.nih.gov/research/umls/sourcereleasedocs/current/VANDF", + NamespacePrefix.WIKIDATA: "https://www.wikidata.org/wiki/", + } +) # URI to source SYSTEM_URI_TO_NAMESPACE = { @@ -540,21 +543,21 @@ class NormalizationService(BaseNormalizationService): { "coding": { "code": "2555", - "system": "https://www.nlm.nih.gov/research/umls/rxnorm/index.html", + "system": "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=", }, "relation": "exactMatch", }, { "coding": { "code": "C376", - "system": "http://purl.obolibrary.org/obo/ncit.owl", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", }, "relation": "relatedMatch", }, { "coding": { "code": "15663-27-1", - "system": "https://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus", + "system": "https://commonchemistry.cas.org/detail?cas_rn=", }, "relation": "relatedMatch", }, @@ -843,7 +846,7 @@ class SearchService(BaseModel): "data_license": "CC0 1.0", "data_license_url": "https://creativecommons.org/publicdomain/zero/1.0/", "version": "5.1.10", - "data_url": "https://go.drugbank.com/releases/latest#open-data", + "data_url": "https://go.drugbank.com/drugs//releases/latest#open-data", "rdp_url": "http://reusabledata.org/drugbank.html", "data_license_attributes": { "non_commercial": False, diff --git a/tests/conftest.py b/tests/conftest.py index 46cb7bd5..bf79dd0d 100644 --- a/tests/conftest.py +++ b/tests/conftest.py @@ -21,6 +21,7 @@ def pytest_collection_modifyitems(items): When creating new test modules, be sure to add them here. """ MODULE_ORDER = [ # noqa: N806 + "test_schemas", "test_chembl", "test_chemidplus", "test_drugbank", diff --git a/tests/data/fixtures/query_fixtures.json b/tests/data/fixtures/query_fixtures.json index 94d0d240..4c22f997 100644 --- a/tests/data/fixtures/query_fixtures.json +++ b/tests/data/fixtures/query_fixtures.json @@ -74,8 +74,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7251" + "id": "ncit:C7251", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7251" }, "relation": "relatedMatch" } @@ -94,8 +95,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7431" + "id": "ncit:C7431", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7431" }, "relation": "relatedMatch" } @@ -114,8 +116,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9334" + "id": "ncit:C9334", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9334" }, "relation": "relatedMatch" } @@ -134,8 +137,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3411" + "id": "ncit:C3411", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3411" }, "relation": "relatedMatch" } @@ -154,8 +158,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/mondo.owl", - "code": "mondo:0850353" + "id": "MONDO_0850353", + "system": "https://purl.obolibrary.org/obo/", + "code": "MONDO:0850353" }, "relation": "relatedMatch" } @@ -174,8 +179,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/mondo.owl", - "code": "mondo:0003060" + "id": "MONDO_0003060", + "system": "https://purl.obolibrary.org/obo/", + "code": "MONDO:0003060" }, "relation": "relatedMatch" } @@ -194,8 +200,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3262" + "id": "ncit:C3262", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3262" }, "relation": "relatedMatch" } @@ -214,8 +221,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7606" + "id": "ncit:C7606", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7606" }, "relation": "relatedMatch" } @@ -234,8 +242,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2929" + "id": "ncit:C2929", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2929" }, "relation": "relatedMatch" } @@ -254,8 +263,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4436" + "id": "ncit:C4436", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4436" }, "relation": "relatedMatch" } @@ -274,8 +284,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3017" + "id": "ncit:C3017", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3017" }, "relation": "relatedMatch" } @@ -294,8 +305,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7478" + "id": "ncit:C7478", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7478" }, "relation": "relatedMatch" } @@ -314,8 +326,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4917" + "id": "ncit:C4917", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4917" }, "relation": "relatedMatch" } @@ -334,8 +347,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7548" + "id": "ncit:C7548", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7548" }, "relation": "relatedMatch" } @@ -354,8 +368,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2915" + "id": "ncit:C2915", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2915" }, "relation": "relatedMatch" } @@ -374,8 +389,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3222" + "id": "ncit:C3222", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3222" }, "relation": "relatedMatch" } @@ -394,8 +410,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3032" + "id": "ncit:C3032", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3032" }, "relation": "relatedMatch" } @@ -414,8 +431,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3247" + "id": "ncit:C3247", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3247" }, "relation": "relatedMatch" } @@ -434,8 +452,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C8851" + "id": "ncit:C8851", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C8851" }, "relation": "relatedMatch" } @@ -454,8 +473,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3149" + "id": "ncit:C3149", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3149" }, "relation": "relatedMatch" } @@ -474,8 +494,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3387" + "id": "ncit:C3387", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3387" }, "relation": "relatedMatch" } @@ -505,8 +526,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3619" + "id": "ncit:C3619", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3619" }, "relation": "relatedMatch" } @@ -525,8 +547,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3468" + "id": "ncit:C3468", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3468" }, "relation": "relatedMatch" } @@ -545,8 +568,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3708" + "id": "ncit:C3708", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3708" }, "relation": "relatedMatch" } @@ -565,8 +589,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2877" + "id": "ncit:C2877", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2877" }, "relation": "relatedMatch" } @@ -585,8 +610,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4962" + "id": "ncit:C4962", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4962" }, "relation": "relatedMatch" } @@ -605,8 +631,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3196" + "id": "ncit:C3196", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3196" }, "relation": "relatedMatch" } @@ -625,8 +652,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7502" + "id": "ncit:C7502", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7502" }, "relation": "relatedMatch" } @@ -645,8 +673,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4699" + "id": "ncit:C4699", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4699" }, "relation": "relatedMatch" } @@ -665,8 +694,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3048" + "id": "ncit:C3048", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3048" }, "relation": "relatedMatch" } @@ -685,8 +715,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4533" + "id": "ncit:C4533", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4533" }, "relation": "relatedMatch" } @@ -705,8 +736,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7190" + "id": "ncit:C7190", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7190" }, "relation": "relatedMatch" } @@ -725,8 +757,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/mondo.owl", - "code": "mondo:0005086" + "id": "MONDO_0005086", + "system": "https://purl.obolibrary.org/obo/", + "code": "MONDO:0005086" }, "relation": "relatedMatch" } @@ -745,8 +778,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3959" + "id": "ncit:C3959", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3959" }, "relation": "relatedMatch" } @@ -765,8 +799,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C34803" + "id": "ncit:C34803", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C34803" }, "relation": "relatedMatch" } @@ -785,8 +820,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7978" + "id": "ncit:C7978", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7978" }, "relation": "relatedMatch" } @@ -805,8 +841,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4890" + "id": "ncit:C4890", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4890" }, "relation": "relatedMatch" } @@ -825,8 +862,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2956" + "id": "ncit:C2956", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2956" }, "relation": "relatedMatch" } @@ -845,8 +883,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3305" + "id": "ncit:C3305", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3305" }, "relation": "relatedMatch" } @@ -865,8 +904,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4013" + "id": "ncit:C4013", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4013" }, "relation": "relatedMatch" } @@ -885,8 +925,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3359" + "id": "ncit:C3359", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3359" }, "relation": "relatedMatch" } @@ -905,8 +946,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3471" + "id": "ncit:C3471", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3471" }, "relation": "relatedMatch" } @@ -925,8 +967,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3568" + "id": "ncit:C3568", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3568" }, "relation": "relatedMatch" } @@ -945,8 +988,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9120" + "id": "ncit:C9120", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9120" }, "relation": "relatedMatch" } @@ -965,8 +1009,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2948" + "id": "ncit:C2948", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2948" }, "relation": "relatedMatch" } @@ -996,8 +1041,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4001" + "id": "ncit:C4001", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4001" }, "relation": "relatedMatch" } @@ -1016,8 +1062,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9231" + "id": "ncit:C9231", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9231" }, "relation": "relatedMatch" } @@ -1036,8 +1083,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7251" + "id": "ncit:C7251", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7251" }, "relation": "relatedMatch" } @@ -1056,8 +1104,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3512" + "id": "ncit:C3512", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3512" }, "relation": "relatedMatch" } @@ -1076,8 +1125,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3552" + "id": "ncit:C3552", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3552" }, "relation": "relatedMatch" } @@ -1096,8 +1146,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3053" + "id": "ncit:C3053", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3053" }, "relation": "relatedMatch" } @@ -1116,8 +1167,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C115965" + "id": "ncit:C115965", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C115965" }, "relation": "relatedMatch" } @@ -1136,8 +1188,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9314" + "id": "ncit:C9314", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9314" }, "relation": "relatedMatch" } @@ -1156,8 +1209,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3242" + "id": "ncit:C3242", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3242" }, "relation": "relatedMatch" } @@ -1176,8 +1230,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C156767" + "id": "ncit:C156767", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C156767" }, "relation": "relatedMatch" } @@ -1196,8 +1251,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7398" + "id": "ncit:C7398", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7398" }, "relation": "relatedMatch" } @@ -1216,8 +1272,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3270" + "id": "ncit:C3270", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3270" }, "relation": "relatedMatch" } @@ -1236,8 +1293,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3161" + "id": "ncit:C3161", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3161" }, "relation": "relatedMatch" } @@ -1256,8 +1314,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7545" + "id": "ncit:C7545", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7545" }, "relation": "relatedMatch" } @@ -1276,8 +1335,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3224" + "id": "ncit:C3224", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3224" }, "relation": "relatedMatch" } @@ -1296,8 +1356,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2858" + "id": "ncit:C2858", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2858" }, "relation": "relatedMatch" } @@ -1316,8 +1377,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9357" + "id": "ncit:C9357", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9357" }, "relation": "relatedMatch" } @@ -1336,8 +1398,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9311" + "id": "ncit:C9311", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9311" }, "relation": "relatedMatch" } @@ -1356,8 +1419,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2926" + "id": "ncit:C2926", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2926" }, "relation": "relatedMatch" } @@ -1387,8 +1451,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3915" + "id": "ncit:C3915", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3915" }, "relation": "relatedMatch" } @@ -1407,8 +1472,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2852" + "id": "ncit:C2852", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2852" }, "relation": "relatedMatch" } @@ -1427,8 +1493,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3780" + "id": "ncit:C3780", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3780" }, "relation": "relatedMatch" } @@ -1447,8 +1514,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3011" + "id": "ncit:C3011", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3011" }, "relation": "relatedMatch" } @@ -1467,8 +1535,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2910" + "id": "ncit:C2910", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2910" }, "relation": "relatedMatch" } @@ -1498,8 +1567,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4627" + "id": "ncit:C4627", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4627" }, "relation": "relatedMatch" } @@ -1518,8 +1588,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3811" + "id": "ncit:C3811", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3811" }, "relation": "relatedMatch" } @@ -1538,8 +1609,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3099" + "id": "ncit:C3099", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3099" }, "relation": "relatedMatch" } @@ -1558,8 +1630,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3549" + "id": "ncit:C3549", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3549" }, "relation": "relatedMatch" } @@ -1578,8 +1651,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3403" + "id": "ncit:C3403", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3403" }, "relation": "relatedMatch" } @@ -1598,8 +1672,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3322" + "id": "ncit:C3322", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3322" }, "relation": "relatedMatch" } @@ -1618,8 +1693,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C6014" + "id": "ncit:C6014", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C6014" }, "relation": "relatedMatch" } @@ -1638,8 +1714,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C36077" + "id": "ncit:C36077", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C36077" }, "relation": "relatedMatch" } @@ -1658,8 +1735,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9309" + "id": "ncit:C9309", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9309" }, "relation": "relatedMatch" } @@ -1678,8 +1756,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7431" + "id": "ncit:C7431", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7431" }, "relation": "relatedMatch" } @@ -1698,8 +1777,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3209" + "id": "ncit:C3209", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3209" }, "relation": "relatedMatch" } @@ -1718,8 +1798,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4044" + "id": "ncit:C4044", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4044" }, "relation": "relatedMatch" } @@ -1738,8 +1819,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3234" + "id": "ncit:C3234", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3234" }, "relation": "relatedMatch" } @@ -1758,8 +1840,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3728" + "id": "ncit:C3728", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3728" }, "relation": "relatedMatch" } @@ -1778,8 +1861,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3752" + "id": "ncit:C3752", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3752" }, "relation": "relatedMatch" } @@ -1798,8 +1882,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3720" + "id": "ncit:C3720", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3720" }, "relation": "relatedMatch" } @@ -1818,8 +1903,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2869" + "id": "ncit:C2869", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2869" }, "relation": "relatedMatch" } @@ -1838,8 +1924,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2916" + "id": "ncit:C2916", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2916" }, "relation": "relatedMatch" } @@ -1858,8 +1945,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3317" + "id": "ncit:C3317", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3317" }, "relation": "relatedMatch" } @@ -1878,8 +1966,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3372" + "id": "ncit:C3372", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3372" }, "relation": "relatedMatch" } @@ -1898,8 +1987,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7541" + "id": "ncit:C7541", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7541" }, "relation": "relatedMatch" } @@ -1918,8 +2008,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9118" + "id": "ncit:C9118", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9118" }, "relation": "relatedMatch" } @@ -1938,8 +2029,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3770" + "id": "ncit:C3770", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3770" }, "relation": "relatedMatch" } @@ -1958,8 +2050,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3208" + "id": "ncit:C3208", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3208" }, "relation": "relatedMatch" } @@ -1978,8 +2071,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3211" + "id": "ncit:C3211", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3211" }, "relation": "relatedMatch" } @@ -1998,8 +2092,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3200" + "id": "ncit:C3200", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3200" }, "relation": "relatedMatch" } @@ -2018,8 +2113,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9334" + "id": "ncit:C9334", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9334" }, "relation": "relatedMatch" } @@ -2038,8 +2134,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3184" + "id": "ncit:C3184", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3184" }, "relation": "relatedMatch" } @@ -2058,8 +2155,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3222" + "id": "ncit:C3222", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3222" }, "relation": "relatedMatch" } @@ -2078,8 +2176,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3012" + "id": "ncit:C3012", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3012" }, "relation": "relatedMatch" } @@ -2098,8 +2197,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C26887" + "id": "ncit:C26887", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C26887" }, "relation": "relatedMatch" } @@ -2118,8 +2218,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C4337" + "id": "ncit:C4337", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C4337" }, "relation": "relatedMatch" } @@ -2149,8 +2250,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9145" + "id": "ncit:C9145", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9145" }, "relation": "relatedMatch" } @@ -2169,8 +2271,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3794" + "id": "ncit:C3794", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3794" }, "relation": "relatedMatch" } @@ -2189,8 +2292,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3257" + "id": "ncit:C3257", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3257" }, "relation": "relatedMatch" } @@ -2209,8 +2313,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3059" + "id": "ncit:C3059", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3059" }, "relation": "relatedMatch" } @@ -2229,8 +2334,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3790" + "id": "ncit:C3790", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3790" }, "relation": "relatedMatch" } @@ -2260,8 +2366,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C8196" + "id": "ncit:C8196", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C8196" }, "relation": "relatedMatch" } @@ -2280,8 +2387,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3156" + "id": "ncit:C3156", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3156" }, "relation": "relatedMatch" } @@ -2300,8 +2408,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C2862" + "id": "ncit:C2862", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C2862" }, "relation": "relatedMatch" } @@ -2320,8 +2429,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7528" + "id": "ncit:C7528", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7528" }, "relation": "relatedMatch" } @@ -2340,8 +2450,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3773" + "id": "ncit:C3773", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3773" }, "relation": "relatedMatch" } @@ -2360,8 +2471,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C34797" + "id": "ncit:C34797", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C34797" }, "relation": "relatedMatch" } @@ -2380,8 +2492,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7558" + "id": "ncit:C7558", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7558" }, "relation": "relatedMatch" } @@ -2400,8 +2513,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C9345" + "id": "ncit:C9345", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C9345" }, "relation": "relatedMatch" } @@ -2420,8 +2534,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C7510" + "id": "ncit:C7510", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C7510" }, "relation": "relatedMatch" } @@ -2440,8 +2555,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C3868" + "id": "ncit:C3868", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C3868" }, "relation": "relatedMatch" } @@ -2460,8 +2576,9 @@ "mappings": [ { "coding": { - "system": "http://purl.obolibrary.org/obo/ncit.owl", - "code": "ncit:C71732" + "id": "ncit:C71732", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C71732" }, "relation": "relatedMatch" } @@ -2485,407 +2602,465 @@ "mappings": [ { "coding": { - "code": "rxcui:2555", - "system": "https://www.nlm.nih.gov/research/umls/rxnorm/index.html" + "id": "rxcui:2555", + "system": "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=", + "code": "2555" }, "relation": "exactMatch" }, { "coding": { - "code": "ncit:C376", - "system": "http://purl.obolibrary.org/obo/ncit.owl" + "id": "ncit:C376", + "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=", + "code": "C376" }, "relation": "relatedMatch" }, { "coding": { - "code": "hemonc:105", - "system": "https://hemonc.org" + "id": "hemonc:105", + "system": "https://hemonc.org", + "code": "105" }, "relation": "relatedMatch" }, { "coding": { - "code": "drugbank:DB00515", - "system": "https://go.drugbank.com" + "id": "drugbank:DB00515", + "system": "https://go.drugbank.com/drugs/", + "code": "DB00515" }, "relation": "relatedMatch" }, { "coding": { - "code": "drugbank:DB12117", - "system": "https://go.drugbank.com" + "id": "drugbank:DB12117", + "system": "https://go.drugbank.com/drugs/", + "code": "DB12117" }, "relation": "relatedMatch" }, { "coding": { - "code": "drugsatfda.anda:074656", - "system": "https://www.fda.gov/drugs/types-applications/abbreviated-new-drug-application-anda" + "id": "drugsatfda.anda:074656", + "system": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=", + "code": "074656" }, "relation": "relatedMatch" }, { "coding": { - "code": "drugsatfda.anda:074735", - "system": "https://www.fda.gov/drugs/types-applications/abbreviated-new-drug-application-anda" + "id": "drugsatfda.anda:074735", + "system": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=", + "code": "074735" }, "relation": "relatedMatch" }, { "coding": { - "code": "drugsatfda.anda:075036", - "system": "https://www.fda.gov/drugs/types-applications/abbreviated-new-drug-application-anda" + "id": "drugsatfda.anda:075036", + "system": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=", + "code": "075036" }, "relation": "relatedMatch" }, { "coding": { - "code": "drugsatfda.anda:206774", - "system": "https://www.fda.gov/drugs/types-applications/abbreviated-new-drug-application-anda" + "id": "drugsatfda.anda:206774", + "system": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=", + "code": "206774" }, "relation": "relatedMatch" }, { "coding": { - "code": "drugsatfda.anda:207323", - "system": "https://www.fda.gov/drugs/types-applications/abbreviated-new-drug-application-anda" + "id": "drugsatfda.anda:207323", + "system": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=", + "code": "207323" }, "relation": "relatedMatch" }, { "coding": { - "code": "drugsatfda.nda:018057", - "system": "https://www.fda.gov/drugs/types-applications/new-drug-application-nda" + "id": "drugsatfda.nda:018057", + "system": "https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=", + "code": "018057" }, "relation": "relatedMatch" }, { "coding": { - "code": "iuphar.ligand:5343", - "system": "https://www.guidetopharmacology.org/GRAC/LigandListForward" + "id": "iuphar.ligand:5343", + "system": "https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=", + "code": "5343" }, "relation": "relatedMatch" }, { "coding": { - "code": "chembl:CHEMBL11359", - "system": "https://www.ebi.ac.uk/chembl/" + "id": "chembl:CHEMBL11359", + "system": "https://www.ebi.ac.uk/chembl/explore/compound/", + "code": "CHEMBL11359" }, "relation": "relatedMatch" }, { "coding": { - "code": "chemidplus:15663-27-1", - "system": "https://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus" + "id": "chemidplus:15663-27-1", + "system": "https://commonchemistry.cas.org/detail?cas_rn=", + "code": "15663-27-1" }, "relation": "relatedMatch" }, { "coding": { - "code": "wikidata:Q412415", - "system": "https://www.wikidata.org" + "id": "wikidata:Q412415", + "system": "https://www.wikidata.org/wiki/", + "code": "Q412415" }, "relation": "relatedMatch" }, { "coding": { - "code": "ndc:0703-5748", - "system": "https://dps.fda.gov/ndc" + "id": "ndc:0703-5748", + "system": "https://dps.fda.gov/ndc/searchresult?selection=finished_product&content=PRODUCTNDC&type=", + "code": "0703-5748" }, "relation": "relatedMatch" }, { "coding": { - "code": "ndc:63323-103", - "system": "https://dps.fda.gov/ndc" + "id": "ndc:63323-103", + "system": "https://dps.fda.gov/ndc/searchresult?selection=finished_product&content=PRODUCTNDC&type=", + "code": "63323-103" }, "relation": "relatedMatch" }, { "coding": { - "code": "ndc:70860-206", - "system": "https://dps.fda.gov/ndc" + "id": "ndc:70860-206", + "system": "https://dps.fda.gov/ndc/searchresult?selection=finished_product&content=PRODUCTNDC&type=", + "code": "70860-206" }, "relation": "relatedMatch" }, { "coding": { - "code": "ndc:44567-509", - "system": "https://dps.fda.gov/ndc" + "id": "ndc:44567-509", + "system": "https://dps.fda.gov/ndc/searchresult?selection=finished_product&content=PRODUCTNDC&type=", + "code": "44567-509" }, "relation": "relatedMatch" }, { "coding": { - "code": "usp:m17910", - "system": "https://www.usp.org/health-quality-safety/compendial-nomenclature" + "id": "usp:m17910", + "system": "https://www.usp.org/health-quality-safety/compendial-nomenclature", + "code": "m17910" }, "relation": "relatedMatch" }, { "coding": { - "code": "ndc:44567-530", - "system": "https://dps.fda.gov/ndc" + "id": "ndc:44567-530", + "system": "https://dps.fda.gov/ndc/searchresult?selection=finished_product&content=PRODUCTNDC&type=", + "code": "44567-530" }, "relation": "relatedMatch" }, { "coding": { - 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