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adding lower bound for pred correction #20

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smouksassi opened this issue Sep 29, 2022 · 0 comments

smouksassi commented Sep 29, 2022 •

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085712/pdf/12248_2011_Article_9255.pdf
the original paper had the following equations for pred correction on original scale ( not log)
pcYij = lbij +(yij-lbij) *(med(PREDbin) - lbij)/(PREDij-lbij)
when lb = 0
reduces to
pcYij =(yij) *(med(PREDbin) )/(PREDij)

similar to how we allow LLOQ at the observation level we should allow lower bound at observation level

https://github.com/certara/tidyvpc/blob/master/R/vpcstats.R#L729
o$obs[, ypc := (mpred/pred)*y]

on a separate note we might also want to add variance correction

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