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Colin Douglas |
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Curriculum vitae for Colin Douglas |
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[colindougl.as/cv]({{ url }}/cv)
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linkedin.com/in/colinddouglas
University of Toronto, Toronto, ON
Ph.D., Biological and Organic Chemistry
Supervisor: Dr. Deborah Zamble
Thesis: Metal Specificity in [NiFe] Hydrogenase Maturation Proteins
St. Francis Xavier University, Antigonish, NS
B.Sc., Chemistry
Supervisor: Dr. Truis Smith-Palmer
Thesis: "Surface Enhanced Raman Spectroscopy of Microbiological Systems"
Public Services and Procurement Canada (Ottawa, ON)
Senior Analyst (EC-06), February 2022 - Present
Data Scientist (EC-04), November 2020 - February 2022
I use R, a statistical programming language, to help people understand whether the policies they're implementing are working.
Precision Biologic Inc. (Dartmouth, NS)
Research and Development Scientist
June 2017 - November 2020
I helped develop and clear two medical devices:
- CryoCheck Factor VIII Inhibitor Kit, which detects inhibitory factor VIII antibodies (K183440)
- CryoCheck Hex LA, which detects lupus anticoagulant through the neutralization of hexagonal phase phospholipid (K193556)
Faculty of Medicine, Dalhousie University (Halifax, NS)
Killam Postdoctoral Fellow
April 2015 - May 2017
I studied mechanism-based inhibitors of enolase enzymes. In one project, I used multivariate non- linear curve fitting to suss out the different steps in an inhibition mechanism, and demonstrated that one molecule we worked with was the tightest known inhibitor of it’s target enzyme.
- C.D. Douglas, L. Grandinetti, N.M. Easton, O.P. Kuehm, J.A. Hyaden, M.C. Hamilton, M. St. Maurice, S.L. Bearne. (2021). Slow-Onset, Potent Inhibition of Mandelate Racemase by 2-Formylphenylboronic Acid. An Unexpected Adduct Clasps the Catalytic Machinery. Biochemistry 60, 2508-18. [ft]
- C.D. Douglas, R. Clarke, N. Kesavan, D. Lamont, A. Sadeghi-Khomami, A. Wood, K.M. Black (Oct 2020). Comparison of Hexagonal Phase Phospholipid Neutralization Assays for Lupus Anticoagulant Detection. Poster presented at the THSNA 2020 Virtual Conference.
- C.D. Douglas, R. Clarke, N. Kesavan, D. Lamont, A. Sadeghi-Khomami, A. Wood, K.M. Black (July 2020). Laboratory Validation of a Novel Hexagonal Phase Phospholipid Neutralization Assay for Lupus Anticoagulant Detection. Poster presented at the ISTH Virtual Congress.
- C.D. Douglas, A. Wood, A. Sadeghi-Khomami, K.M. Black (September 2019). Effects of Common Interferents in Hexagonal Phase Phospholipid Neutralization Testing. Poster presented at the 16th International Congress on Antiphospholipid Antibodies, Manchester, UK.
- C.M. Fetter, Z.A. Morrison, M. Nagar, C.D. Douglas, S.L. Bearne (2019). Altering the Y137-K164-K166 triad of mandelate racemase and its effect on the observed pKa of the Brønsted base catalysts. Arch. Biochem. Biophys. 666, 116-126. [ft]
- C.D. Douglas, T. Quinton, E. Cabanban, K.M. Black, A. Sadeghi-Khomami (December 2018). A Standardized Kit for a Chromogenic Modified Nijmegen-Bethesda Assay. Poster presented at the 60th ASH Annual Meeting, San Diego, CA.
- C.D. Douglas, S.L. Bearne (June 2017). 2-Formylphenylboronate, a Potent Inhibitor of Mandelate Racemase. Oral presentation at the 100th Canadian Chemistry Conference and Exhibition, Toronto, ON.
- M.J. Lacasse, C.D. Douglas, D.B. Zamble (2016). Mechanism of Selective Nickel Transfer from Hydrogenase Accessory Proteins. Biochemistry 55, 6821–31. [ft]
- C.D. Douglas, D.B. Zamble (January 2014). The role of accessory proteins in the nickel insertion step of E. coli [NiFe] hydrogenase maturation. Oral presentation at the Gordon Conference on Metals in Biology, Ventura, CA.
- C.D. Douglas, T.T. Ngu, H. Kaluarachchi, D.B. Zamble (2013). Metal Transfer within the Escherichia coli HypB–HypA Complex of Hydrogenase Accessory Proteins. Biochemistry 52, 6030–6039. [ft]
- A.M. Sydor, M. Jost, K.S. Ryan, K.E. Turo, C.D. Douglas, C.L. Drennan, D.B. Zamble (2013). Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases. Biochemistry 52, 1788–1801. [ft]
- C.D. Douglas, A.D. Dias, D.B. Zamble (2012). The metal selectivity of a short peptide maquette imitating the high-affinity metal-binding site of E. coli HypB. Dalton Trans. 41, 7876–7878. [ft]
- C.D. Douglas, A.D. Dias, D.B. Zamble (June 2010). Probing the Selectivity of a High-Affinity Metal-Binding Peptide. Poster presentation at the 93rd Canadian Chemistry Conference and Exhibition, Toronto, ON.
- T. Smith-Palmer, C.D. Douglas, P. Fredericks (2010). Rationalizing the SER spectra of bacteria. Vib. Spectrosc. 53, 103–106. [ft]
- J.W.D. Comeau, J. Pink, E. Bezanson, C.D. Douglas, D. Pink, T. Smith-Palmer (2009). A comparison of Pseudomonas aeruginosa biofilm development on ZnSe and TiO2 using attenuated total reflection Fourier transform infrared spectroscopy. Appl. Spectrosc. 63, 1000–1007. [ft]
- M. Kazanci, J.P. Schulte, C.D. Douglas, P. Fratzl, D. Pink, T. Smith-Palmer (2009). Tuning the surface-enhanced Raman scattering effect to different molecular groups by switching the silver colloid solution pH. Appl. Spectrosc. 63, 214–223. [ft]
- D.T. Walker, C.D. Douglas, B.J. MacLean (2009). Synthesis, characterization, and surface studies of conjugated polymers possessing 2,2'-biimidazole moieties. Can. J. Chem. 87, 729–737. [ft]
- C.D. Douglas, D. Pink, T. Smith-Palmer (2009, June). Surface-enhanced Raman Scattering of Microbiological Systems. Poster presentation at the 92nd Canadian Chemistry Conference and Exhibition, Hamilton, ON.
2015 - 2017 | Killam Postdoctoral Fellowship, Dalhousie University 2010 - 2013 | Alexander Graham Bell Scholarship, (CGS-D), NSERC 2009 - 2010 | Alexander Graham Bell Scholarship, (CGS-M), NSERC 2005 - 2009 | Philip W. Oland Scholarship, St. Francis Xavier University
| description | role bcsxp | an R package for reading ASCII data from Siemens BCS XP coagulation analyzers| creator, maintainer retrosheet | an R package for importing historical baseball data from retrosheet.org | maintainer
some keywords for your ATS:
Data Science | R, SQL, time series forecasting, web scraping, automated report generation Clinical Chemistry | Coagulation, assay development and validation, FDA 510(k) program, regulation of medical devices Molecular Biology | Molecular cloning, protein expression and purification, enzyme kinetics, structure-function Analytical Chemistry | HPLC, mass spectrometry, Raman spectroscopy, circular dichroism