diff --git a/integrations/amazon_bedrock/src/haystack_integrations/components/generators/amazon_bedrock/chat/chat_generator.py b/integrations/amazon_bedrock/src/haystack_integrations/components/generators/amazon_bedrock/chat/chat_generator.py
index 988452a97..e1732646a 100644
--- a/integrations/amazon_bedrock/src/haystack_integrations/components/generators/amazon_bedrock/chat/chat_generator.py
+++ b/integrations/amazon_bedrock/src/haystack_integrations/components/generators/amazon_bedrock/chat/chat_generator.py
@@ -58,7 +58,7 @@ class AmazonBedrockChatGenerator:
     """
 
     SUPPORTED_MODEL_PATTERNS: ClassVar[Dict[str, Type[BedrockModelChatAdapter]]] = {
-        r"anthropic.claude.*": AnthropicClaudeChatAdapter,
+        r"(.+\.)?anthropic.claude.*": AnthropicClaudeChatAdapter,
         r"meta.llama2.*": MetaLlama2ChatAdapter,
         r"mistral.*": MistralChatAdapter,
     }
diff --git a/integrations/amazon_bedrock/src/haystack_integrations/components/generators/amazon_bedrock/generator.py b/integrations/amazon_bedrock/src/haystack_integrations/components/generators/amazon_bedrock/generator.py
index 6ef0a4765..1edde3526 100644
--- a/integrations/amazon_bedrock/src/haystack_integrations/components/generators/amazon_bedrock/generator.py
+++ b/integrations/amazon_bedrock/src/haystack_integrations/components/generators/amazon_bedrock/generator.py
@@ -69,7 +69,7 @@ class AmazonBedrockGenerator:
         r"ai21.j2.*": AI21LabsJurassic2Adapter,
         r"cohere.command-[^r].*": CohereCommandAdapter,
         r"cohere.command-r.*": CohereCommandRAdapter,
-        r"anthropic.claude.*": AnthropicClaudeAdapter,
+        r"(.+\.)?anthropic.claude.*": AnthropicClaudeAdapter,
         r"meta.llama.*": MetaLlamaAdapter,
         r"mistral.*": MistralAdapter,
     }
diff --git a/integrations/amazon_bedrock/tests/test_chat_generator.py b/integrations/amazon_bedrock/tests/test_chat_generator.py
index a455d2c93..49abc0979 100644
--- a/integrations/amazon_bedrock/tests/test_chat_generator.py
+++ b/integrations/amazon_bedrock/tests/test_chat_generator.py
@@ -254,6 +254,8 @@ def test_long_prompt_is_not_truncated_when_truncate_false(mock_boto3_session):
     [
         ("anthropic.claude-v1", AnthropicClaudeChatAdapter),
         ("anthropic.claude-v2", AnthropicClaudeChatAdapter),
+        ("eu.anthropic.claude-v1", AnthropicClaudeChatAdapter),  # cross-region inference
+        ("us.anthropic.claude-v2", AnthropicClaudeChatAdapter),  # cross-region inference
         ("anthropic.claude-instant-v1", AnthropicClaudeChatAdapter),
         ("anthropic.claude-super-v5", AnthropicClaudeChatAdapter),  # artificial
         ("meta.llama2-13b-chat-v1", MetaLlama2ChatAdapter),
diff --git a/integrations/amazon_bedrock/tests/test_generator.py b/integrations/amazon_bedrock/tests/test_generator.py
index f0233888c..61ae9d6b4 100644
--- a/integrations/amazon_bedrock/tests/test_generator.py
+++ b/integrations/amazon_bedrock/tests/test_generator.py
@@ -231,6 +231,8 @@ def test_long_prompt_is_not_truncated_when_truncate_false(mock_boto3_session):
     [
         ("anthropic.claude-v1", AnthropicClaudeAdapter),
         ("anthropic.claude-v2", AnthropicClaudeAdapter),
+        ("eu.anthropic.claude-v1", AnthropicClaudeAdapter),  # cross-region inference
+        ("us.anthropic.claude-v2", AnthropicClaudeAdapter),  # cross-region inference
         ("anthropic.claude-instant-v1", AnthropicClaudeAdapter),
         ("anthropic.claude-super-v5", AnthropicClaudeAdapter),  # artificial
         ("cohere.command-text-v14", CohereCommandAdapter),