This is the repo for the manuscript "Spatial clonal evolution and clone-specific microenvironment interactions within three-dimensional tumor structures"
- Figure 1. Definition of tumor spatial microregions
- Figure 2. Genetic alteration reveals spatial clonal evolution
- Figure 3. Genetic alteration drives transcriptional similarity in tumor microregions
- Figure 4. Spatial expression pattern associated with tumor depth
- Figure 5. Immune and stromal infiltration inside spatial tumor microregion
- Figure 6. 3D tumor volume reconstruction revealed diverse tumor growth patterns
- Figure 7. Tumor-TME interaction in microregion boundary regions demonstrates heterogeneity