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-# ST subclone manuscript
+# Tumour evolution and microenvironment interactions in 2D and 3D space
+
+![image](https://github.com/user-attachments/assets/f915b5be-79dc-4c32-b88b-74f3b220e78c)
+
+
 ## Overview
 This is the repo for the manuscript "Spatial clonal evolution and clone-specific microenvironment interactions within three-dimensional tumor structures"
 
 ## Repo structure 
 * Figure 1. Spatial microregions across cancers
 * Figure 2. Focal clonal evolution in microregions
-* Figure 3. Genetic changes drive tumour disparities & Cellular pathway at tumour core and edge
+* Figure 3. Genetic changes drive tumour disparities & Cellular pathways at tumour core and edge
 * Figure 4. Clonal-specific Tumor-TME interaction 
 * Figure 5 & 6. 3D tumour structure and TME interactions 
 
-## Data Access instruction
-Data file for each data type can be access using ID listed in the file "Data_access/Sample_ID_Lookup_table_v1.xlsx"
-Please see the readme in the .xlsx file and under the folder for more instructions
+## Data Access
+Data file for each data type can be accessed using ID listed in the file "Data_access/Sample_ID_Lookup_table_v1.xlsx"
+
+* CPTAC: CPTAC snRNA-seq data can be accessed through NIH GDC Data Portal using the CPTAC Case ID: https://portal.gdc.cancer.gov/cases/
+
+* HTAN: HTAN data can be accessed with HTAN Biospecimen and HTAN Participant ID on HTAN DCC, WUSTL Atlas: https://humantumoratlas.org/explore?selectedFilters=%5B%7B%22group%22%3A%22AtlasName%22%2C%22value%22%3A%22HTAN+WUSTL%22%7D%5D&tab=file
+
+## Manuscript:
+DOI
+https://doi.org/10.1038/s41586-024-08087-4
+
+## Cite this article
+Mo, CK., Liu, J., Chen, S. et al. Tumour evolution and microenvironment interactions in 2D and 3D space. Nature 634, 1178–1186 (2024). https://doi.org/10.1038/s41586-024-08087-4