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simoncmo committed Dec 10, 2023
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# st_subclone
Code for spatial subclone paper
# ST subclone manuscript
This is the repo for the manuscript "Spatial clonal evolution and clone-specific microenvironment interactions within three-dimensional tumor structures"

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* Figure 1. Definition of tumor spatial microregions
* Figure 2. Genetic alteration reveals spatial clonal evolution
* Figure 3. Genetic alteration drives transcriptional similarity in tumor microregions
* Figure 4. Spatial expression pattern associated with tumor depth
* Figure 5. Immune and stromal infiltration inside spatial tumor microregion
* Figure 6. 3D tumor volume reconstruction revealed diverse tumor growth patterns
* Figure 7. Tumor-TME interaction in microregion boundary regions demonstrates heterogeneity

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