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-# st_subclone
-Code for spatial subclone paper
+# ST subclone manuscript
+This is the repo for the manuscript "Spatial clonal evolution and clone-specific microenvironment interactions within three-dimensional tumor structures" 
+
+---
+
+* Figure 1. Definition of tumor spatial microregions
+* Figure 2. Genetic alteration reveals spatial clonal evolution
+* Figure 3. Genetic alteration drives transcriptional similarity in tumor microregions
+* Figure 4. Spatial expression pattern associated with tumor depth
+* Figure 5. Immune and stromal infiltration inside spatial tumor microregion
+* Figure 6. 3D tumor volume reconstruction revealed diverse tumor growth patterns
+* Figure 7. Tumor-TME interaction in microregion boundary regions demonstrates heterogeneity