diff --git a/src/dstack/_internal/cli/commands/run.py b/src/dstack/_internal/cli/commands/run.py
index cbe3ca76a..9c8be0356 100644
--- a/src/dstack/_internal/cli/commands/run.py
+++ b/src/dstack/_internal/cli/commands/run.py
@@ -106,7 +106,8 @@ def _command(self, args: argparse.Namespace):
             parser = argparse.ArgumentParser()
             configurator = run_configurators_mapping[ConfigurationType(conf.type)]
             configurator.register(parser)
-            configurator.apply(parser.parse_args(args.unknown), conf)
+            args, unknown = parser.parse_known_args(args.unknown)
+            configurator.apply(args, unknown, conf)
 
             with console.status("Getting run plan..."):
                 run_plan = self.api.runs.get_plan(
diff --git a/src/dstack/_internal/cli/services/configurators/run.py b/src/dstack/_internal/cli/services/configurators/run.py
index f1e5f9d97..164ad7e41 100644
--- a/src/dstack/_internal/cli/services/configurators/run.py
+++ b/src/dstack/_internal/cli/services/configurators/run.py
@@ -11,7 +11,10 @@
     ConfigurationType,
     DevEnvironmentConfiguration,
     PortMapping,
+    ServiceConfiguration,
+    TaskConfiguration,
 )
+from dstack._internal.utils.interpolator import VariablesInterpolator
 
 
 class BaseRunConfigurator:
@@ -30,11 +33,20 @@ def register(cls, parser: argparse.ArgumentParser):
         )
 
     @classmethod
-    def apply(cls, args: argparse.Namespace, conf: BaseConfiguration):
+    def apply(cls, args: argparse.Namespace, unknown: List[str], conf: BaseConfiguration):
         if args.envs:
             for k, v in args.envs:
                 conf.env[k] = v
 
+        cls.interpolate_run_args(conf.setup, unknown)
+
+    @classmethod
+    def interpolate_run_args(cls, value: List[str], unknown):
+        run_args = " ".join(unknown)
+        interpolator = VariablesInterpolator({"run": {"args": run_args}}, skip=["secrets"])
+        for i in range(len(value)):
+            value[i] = interpolator.interpolate(value[i])
+
 
 class RunWithPortsConfigurator(BaseRunConfigurator):
     @classmethod
@@ -51,8 +63,8 @@ def register(cls, parser: argparse.ArgumentParser):
         )
 
     @classmethod
-    def apply(cls, args: argparse.Namespace, conf: BaseConfigurationWithPorts):
-        super().apply(args, conf)
+    def apply(cls, args: argparse.Namespace, unknown: List[str], conf: BaseConfigurationWithPorts):
+        super().apply(args, unknown, conf)
         if args.ports:
             conf.ports = list(merge_ports(conf.ports, args.ports).values())
 
@@ -60,13 +72,21 @@ def apply(cls, args: argparse.Namespace, conf: BaseConfigurationWithPorts):
 class TaskRunConfigurator(RunWithPortsConfigurator):
     TYPE = ConfigurationType.TASK
 
+    @classmethod
+    def apply(cls, args: argparse.Namespace, unknown: List[str], conf: TaskConfiguration):
+        super().apply(args, unknown, conf)
+
+        cls.interpolate_run_args(conf.commands, unknown)
+
 
 class DevEnvironmentRunConfigurator(RunWithPortsConfigurator):
     TYPE = ConfigurationType.DEV_ENVIRONMENT
 
     @classmethod
-    def apply(cls, args: argparse.Namespace, conf: DevEnvironmentConfiguration):
-        super().apply(args, conf)
+    def apply(
+        cls, args: argparse.Namespace, unknown: List[str], conf: DevEnvironmentConfiguration
+    ):
+        super().apply(args, unknown, conf)
         if conf.ide == "vscode" and conf.version is None:
             conf.version = _detect_vscode_version()
             if conf.version is None:
@@ -80,6 +100,12 @@ def apply(cls, args: argparse.Namespace, conf: DevEnvironmentConfiguration):
 class ServiceRunConfigurator(BaseRunConfigurator):
     TYPE = ConfigurationType.SERVICE
 
+    @classmethod
+    def apply(cls, args: argparse.Namespace, unknown: List[str], conf: ServiceConfiguration):
+        super().apply(args, unknown, conf)
+
+        cls.interpolate_run_args(conf.commands, unknown)
+
 
 def env_var(v: str) -> Tuple[str, str]:
     r = re.match(r"^([a-zA-Z_][a-zA-Z0-9_]*)=(.*)$", v)
diff --git a/src/tests/_internal/cli/services/configurators/test_run.py b/src/tests/_internal/cli/services/configurators/test_run.py
index e36c28c97..48acd874e 100644
--- a/src/tests/_internal/cli/services/configurators/test_run.py
+++ b/src/tests/_internal/cli/services/configurators/test_run.py
@@ -67,6 +67,6 @@ def apply_args(
     configurator = run_configurators_mapping[conf.type]
     configurator.register(parser)
     conf = conf.copy(deep=True)  # to avoid modifying the original configuration
-    args = parser.parse_args(args)
-    configurator.apply(args, conf)
+    args, unknown = parser.parse_known_args(args)
+    configurator.apply(args, unknown, conf)
     return conf, args