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Copy pathNM_198510.gb
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NM_198510.gb
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LOCUS NM_198510 4964 bp mRNA linear PRI 25-DEC-2022
DEFINITION Homo sapiens inter-alpha-trypsin inhibitor heavy chain family
member 6 (ITIH6), mRNA.
ACCESSION NM_198510 XM_293311
VERSION NM_198510.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4964)
AUTHORS Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
MA.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (bases 1 to 4964)
AUTHORS Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J,
Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D,
Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS,
Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M,
Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J,
Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods
K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard
A, Wood WI, Godowski P and Gray A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from Z98046.1, AY358170.1 and
CA413764.1.
This sequence is a reference standard in the RefSeqGene project.
On May 17, 2019 this sequence version replaced NM_198510.2.
Summary: The protein encoded by this gene belongs to the interalpha
trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin
inhibitor (ITI) is composed of two heavy chains (containing VWA
domain) and one light chain. The light chain confers the
protease-inhibitor function, while the heavy chains are involved in
mediating protein-protein interactions with the components of the
extracellular matrix. [provided by RefSeq, Sep 2009].
##Evidence-Data-START##
Transcript exon combination :: AY358170.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1968832,
SAMEA2142853 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000218436.7/ ENSP00000218436.6
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-15 Z98046.1 42443-42457 c
16-4699 AY358170.1 1-4684
4700-4964 CA413764.1 37-301 c
FEATURES Location/Qualifiers
source 1..4964
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp11.22"
gene 1..4964
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="inter-alpha-trypsin inhibitor heavy chain family
member 6"
/db_xref="GeneID:347365"
/db_xref="HGNC:HGNC:28907"
exon 1..147
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
CDS 46..3987
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="ITI-like protein; inter-alpha-trypsin inhibitor
heavy chain H5-like protein; inter-alpha inhibitor H5-like
protein; inter-alpha-trypsin inhibitor heavy chain H6"
/codon_start=1
/product="inter-alpha-trypsin inhibitor heavy chain H6
precursor"
/protein_id="NP_940912.1"
/db_xref="CCDS:CCDS14361.1"
/db_xref="GeneID:347365"
/db_xref="HGNC:HGNC:28907"
/translation="MSGWRYLICVSFLLTILLELTYQGPPVPASSSTKLLMTSYSMRS
TVVSRYAHTLVTSVLFNPHAEAHEAIFDLDLPHLAFISNFTMTINNKVYIAEVKEKHQ
AKKIYEEAHQQGKTAAHVGIRDRESEKFRISTSLAAGTEVTFSLAYEELLQRHQGQYQ
LVVSLRPGQLVKRLSIEVTVSERTGISYVHIPPLRTGRLRTNAHASEVDSPPSTRIER
GETCVRITYCPTLQDQSSISGSGIMADFLVQYDVVMEDIIGDVQIYDDYFIHYFAPRG
LPPMEKNVVFVIDVSSSMFGTKMEQTKTAMNVILSDLQANDYFNIISFSDTVNVWKAG
GSIQATIQNVHSAKDYLHCMEADGWTDVNSALLAAASVLNHSNQEPGRGPSVGRIPLI
IFLTDGEPTAGVTTPSVILSNVRQALGHRVSLFSLAFGDDADFTLLRRLSLENRGIAR
RIYEDTDAALQLKGLYEEISMPLLADVRLNYLGGLVGASPWAVFPNYFGGSELVVAGQ
VQPGKQELGIHLAARGPKDQLLVAHHSEGATNNSQKAFGCPGEPAPNVAHFIRRLWAY
VTIGELLDAHFQARDTTTRHLLAAKVLNLSLEYNFVTPLTSLVMVQPKQASEETRRQT
STSAGPDTIMPSSSSRHGLGVSTAQPALVPKVISPKSRPVKPKFYLSSTTTASTKKML
SSKELEPLGESPHTLSMPTYPKAKIPAQQDSGTLAQPTLRTKPTILVPSNSGTLLPLK
PGSLSHQNPDILPTNSRTQVPPVKPGIPASPKADTVKCVTPLHSKPGAPSHPQLGALT
SQAPKGLPQSRPGVSTLQVPKYPLHTRPRVPAPKTRNNMPHLGPGILLSKTPKILLSL
KPSAPPHQISTSISLSKPETPNPHMPQTPLPPRPDRPRPPLPESLSTFPNTISSSTGP
SSTTTTSVLGEPLPMPFTPTLPPGRFWHQYDLLPGPQRTRQVLGPSRPGVPTMSLLNS
SRPTPEGSPPNLPILLPSSILPEAISLLLLPEELELLSESMVESKFVESLNPPAFYTF
LTPDEDGSPNWDGNSEEILGGAGGSMESQGSSVGLAKGTLPSIFTFSSSVDGDPHFVI
QIPHSEEKICFTLNGHPGDLLQLIEDPKAGLHVSGKLLGAPPRPGHKDQTRTYFQIIT
VTTDKPRAYTITISRSSISLRGEGTLRLSWDQPALLKRPQLELYVAAAARLTLRLGPY
LEFLVLRHRYRHPSTLQLPHLGFYVANGSGLSPSARGLIGQFQHADIRLVTGPMGPCL
RRHHGPDVPVILGKRLLKDSPRLLPRWASCWLVKRSHVELLLGHPYLSYVL"
sig_peptide 46..114
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 115..3984
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/product="Inter-alpha-trypsin inhibitor heavy chain H6.
/id=PRO_0000285680"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXX5.1)"
misc_feature 292..294
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6UXX5.1); glycosylation site"
misc_feature 1165..1167
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6UXX5.1); glycosylation site"
misc_feature 1663..1665
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6UXX5.1); glycosylation site"
misc_feature 1825..1827
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6UXX5.1); glycosylation site"
misc_feature 1879..1977
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXX5.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2392..2496
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXX5.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2611..2829
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXX5.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2920..2994
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXX5.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2956..2958
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6UXX5.1); glycosylation site"
misc_feature 3736..3738
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6UXX5.1); glycosylation site"
exon 148..302
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 303..413
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 414..661
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 662..831
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 832..948
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 949..1120
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 1121..3154
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 3155..3247
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 3248..3283
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 3284..3397
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 3398..3775
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
exon 3776..4964
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/inference="alignment:Splign:2.1.0"
regulatory 4686..4691
/regulatory_class="polyA_signal_sequence"
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="hexamer: AGTAAA"
polyA_site 4706
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="major polyA site"
regulatory 4943..4948
/regulatory_class="polyA_signal_sequence"
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="hexamer: CATAAA"
polyA_site 4964
/gene="ITIH6"
/gene_synonym="dJ14O9.1; ITIH5L; UNQ6369"
/note="major polyA site"
ORIGIN
1 agatcttctg gatgtgaaca acagatccag gccagaggtg gcatcatgtc tgggtggagg
61 tacctcatct gtgtcagctt tttgctgacc attcttcttg aactgacata ccagggaccc
121 cctgtccccg cttcatcaag cacaaagttg ttaatgacaa gctattctat gcgctccacg
181 gtggtgtctc gctatgccca caccttggtc acctctgtcc tgtttaatcc acatgctgaa
241 gcccatgaag ccatctttga cctggatctg cctcatcttg cctttatctc caatttcact
301 atgaccatca acaataaagt ctacattgca gaagtcaaag agaagcacca ggcaaagaaa
361 atctatgaag aagcccatca gcagggaaag acagctgctc atgtaggcat cagggaccgg
421 gaatcagaga agttccgcat ctccaccagc ctggcagcag gcacagaggt gactttttcc
481 ctggcctatg aggaactgct tcagcggcac cagggccagt accagctggt ggtgagcctg
541 aggcctggcc aattggtgaa gaggctgagc atagaggtta cagtgtcaga aaggacaggc
601 atctcctatg tgcacatacc acccctgagg accggccgtc tgcgcaccaa tgcccatgca
661 agtgaggtgg attcaccccc atccaccagg atcgagaggg gagagacctg tgtccgaatc
721 acctactgcc cgacattgca agaccagtcg tccatctctg ggtcaggcat catggctgac
781 ttcctggttc agtacgatgt ggtcatggag gacatcattg gagacgtgca gatttacgat
841 gactatttca ttcactactt tgcccccaga ggccttccac ctatggagaa gaatgtggtt
901 tttgttattg acgtaagcag ctccatgttt ggtaccaaga tggaacagac taaaacggcc
961 atgaatgtga tcctcagtga ccttcaagcc aatgactact tcaacatcat ctccttttct
1021 gacacagtta atgtttggaa agctggaggc tcaatccagg ccaccatcca gaatgtccac
1081 agtgccaagg actacctgca ttgcatggaa gccgatggct ggacagacgt caactcagct
1141 ctgctggcag ctgcttcagt gctgaaccat agcaaccagg agcctgggag gggccccagt
1201 gtggggagga tccctcttat catcttcctg acggatgggg agcccacggc cggcgtgacg
1261 acccccagtg tgatcctctc caatgtccgt caggcgctag gccacagggt atcccttttc
1321 agcttggcct ttggggatga tgctgacttt acactgctgc gccgcctgtc cctggaaaac
1381 cggggaatag cccggcgcat atatgaggac actgatgcgg ccctacagct gaagggcctc
1441 tatgaggaga tctccatgcc tctgctggca gatgtgcgtc tgaactacct gggtggcttg
1501 gttggggcct ccccttgggc cgttttcccc aactactttg gtggctctga gctggtggtg
1561 gcaggacagg tgcagccagg caaacaggaa ctgggcatcc acctggcagc ccgtggcccc
1621 aaggatcagc ttcttgtggc ccaccacagt gaaggggcca ccaacaacag ccagaaggcc
1681 tttggttgcc caggggagcc agcccccaat gtggcccact tcatccgccg cctctgggcc
1741 tatgtcacca ttggagaact gctggatgca cacttccaag ctcgtgacac caccactcgc
1801 cacctgctgg ctgccaaagt cctcaacctg tcccttgaat acaactttgt cacacctctg
1861 acttcactgg tcatggtgca acccaaacag gccagtgagg agaccaggag acagacttcc
1921 acctctgctg ggccagacac catcatgccc tcatccagca gcaggcatgg cctaggggta
1981 agcacagctc agccagcctt ggtgcccaag gtcatctccc ccaaatcaag gcctgtgaaa
2041 ccaaagttct acttatcctc aactactact gcctctacca agaagatgct aagttccaaa
2101 gagctggagc cattgggaga gagccctcat accctgtcaa tgcccacata cccaaaggcc
2161 aaaattccag cacaacagga ttctggcacc ttggcccagc caactctcag gacaaaacct
2221 accattcttg tgccctcaaa ttctggtact ctgttgcctc tgaagcccgg ctctctatca
2281 caccagaatc ctgatatatt acccacgaac tccaggacac aagtcccacc tgtgaaacct
2341 ggcatcccag cctcgcccaa agctgacact gtgaaatgtg ttactccact gcattccaaa
2401 cctggtgctc catcgcaccc ccaacttggg gcactcacat cacaggcacc taaaggcctg
2461 ccacagtcaa gacctggagt ctctacactt caggttccca agtacccact acacaccaga
2521 cctagggttc ctgctcccaa gacccgaaac aacatgccac acctggggcc tggaatcctc
2581 ttgtccaaga cccctaaaat cttattatct cttaaaccga gtgccccacc acaccaaatt
2641 tccacaagca tatcactttc caagcctgag accccaaacc cccatatgcc tcaaacccca
2701 ctacctccta gacctgacag accaaggccc ccacttcctg agagcctaag cacattccca
2761 aatacaatct caagttccac aggtcccagc agtaccacaa ccacctctgt ccttggagaa
2821 cccctcccca tgccctttac tcccactctg ccccctggaa ggttctggca tcagtatgac
2881 ctcctcccgg gtccccagag gaccaggcaa gttctgggac catctaggcc aggagttcca
2941 acaatgagcc tactcaacag ctccaggcct acaccagaag gcagccctcc aaacctgcca
3001 atcttgctgc cttctagcat cctccctgag gccatcagtc tgctccttct ccctgaggag
3061 ctagagctgc tgtctgaatc aatggtggaa tccaagttcg tggagtcctt gaacccacca
3121 gctttctata ccttcctcac tcctgatgaa gatggaagtc caaactggga tggcaattct
3181 gaggagatcc tgggaggagc tggaggcagc atggaatctc aaggaagttc tgtggggtta
3241 gcaaaaggca cattgcctag catcttcacc ttctcctcct cagtggacgg ggacccccac
3301 tttgtgatcc aaatcccaca ctcagaagag aagatctgct tcacactgaa tgggcaccct
3361 ggggacttgc tgcagctcat agaggaccca aaggcagggc tgcatgtgag tgggaagctg
3421 cttggcgcac caccaaggcc gggccacaag gaccagactc gcacctactt ccagatcatc
3481 acagtcacta cagacaaacc ccgggcctat actatcacca tcagccgcag ttctatatct
3541 ttgcgaggcg agggtacctt gcgcctgtcc tgggaccaac ctgccctgct gaagaggccc
3601 cagctggagc tctatgtggc tgctgcagcc cgccttaccc tccgccttgg gccctacctt
3661 gagttcctag tcctccgaca ccgctacagg catcccagta ccctgcaact accccacctg
3721 gggttctacg tggccaatgg ctcaggcctc agcccctcag cccgtggcct gatagggcag
3781 ttccagcacg cagacatccg actggtgaca ggacctatgg ggccatgctt acgaaggcac
3841 catggcccag atgtgcctgt gattctaggc aagaggctgc tgaaggactc accaaggctg
3901 ctgccccgct gggcttcctg ctggctggtg aagcgctctc atgtagagct gcttctgggc
3961 cacccctacc tctcctatgt cctgtgatgg cttctgaatt ccagagccag gagacctgaa
4021 tttgggagat ccagaaacca gggcatgggg tgagccaggg acagagaccc aaggacatgg
4081 aagcacacac agggacacac agactcacgc atgttctaag gaacacatat acaagggtat
4141 acaaacacat agacatgcag agacatagag tcagggactc ctgcatcttc atggtccttc
4201 acatctccag tctcaccctc tccaaatcca tgctcctcac cagccctaca agccactttt
4261 gtaaaacgaa aaaatgatca gtagttctgc tcacagcttt ccctaactcc tatggcatat
4321 tcaaggctct cagagtttcc ctaacaaacc atgctcactc ctaccactgg accattgcat
4381 gtgcttttcc ttctgcatga aacactcttc ctttgttcct gtaggtgagt ataattcatc
4441 cttcaaatcc tagttgttac ctcttctagg aggcctttcc tgatgcctgc cctagattga
4501 gtttggtcct gtcctctggg ttcctatagc ccacccccaa ccctccacgc tcacagtatt
4561 tatactgtgt agtaatcatc tgtttacttg tctggatccc tgacttagac tgtgagatct
4621 ttgagggcaa ggaccttttc tgaatcatct atgtatcccc agtgcctctc acataatagg
4681 tgcttagtaa atatttgtta aaagaatgaa ttaattaatt aacaaaaaag gatcccataa
4741 catagcaata gacacacata tatacatact cacaaccaaa gacacaggat cacacccgga
4801 aaaacagtga caagggcaca gatatggatg gatagaggga cagacattta tggaaacaca
4861 ggaatcacaa aacaaacatg gacatagggg tatagagaca taaaaagatg gggacaggga
4921 gccagagtgg cagaatcagg gacataaact cagagaaaaa ggaa
//