diff --git a/x-pack/plugins/security_solution/public/management/cypress/e2e/response_actions/isolate_mocked_data.cy.ts b/x-pack/plugins/security_solution/public/management/cypress/e2e/response_actions/isolate_mocked_data.cy.ts
index c5d88ad5420b1..a7f600521e8f3 100644
--- a/x-pack/plugins/security_solution/public/management/cypress/e2e/response_actions/isolate_mocked_data.cy.ts
+++ b/x-pack/plugins/security_solution/public/management/cypress/e2e/response_actions/isolate_mocked_data.cy.ts
@@ -29,7 +29,8 @@ import { indexNewCase } from '../../tasks/index_new_case';
 import { indexEndpointHosts } from '../../tasks/index_endpoint_hosts';
 import { indexEndpointRuleAlerts } from '../../tasks/index_endpoint_rule_alerts';
 
-describe('Isolate command', { tags: ['@ess', '@serverless', '@brokenInServerless'] }, () => {
+// Failing: See https://github.com/elastic/kibana/issues/182459
+describe.skip('Isolate command', { tags: ['@ess', '@serverless', '@brokenInServerless'] }, () => {
   describe('from Manage', () => {
     let endpointData: ReturnTypeFromChainable<typeof indexEndpointHosts> | undefined;
     let isolatedEndpointData: ReturnTypeFromChainable<typeof indexEndpointHosts> | undefined;