diff --git a/.github/workflows/test-with-pip.yml b/.github/workflows/test-with-pip.yml
index 433c4fb96..cd41027e9 100644
--- a/.github/workflows/test-with-pip.yml
+++ b/.github/workflows/test-with-pip.yml
@@ -12,8 +12,8 @@ jobs:
   test-ets:
     strategy:
       matrix:
-        os: ['ubuntu-latest', 'macos-latest', 'windows-latest']
-        toolkit: ['null', 'pyside2', 'pyside6', 'pyqt5', 'wx']
+        os: ['ubuntu-latest'] # 'macos-latest', 'windows-latest']
+        toolkit: ['null'] #, 'pyside2', 'pyside6', 'pyqt5', 'wx']
         python-version: ['3.8', '3.10', '3.11']
         exclude:
           # No Wx wheels available for Python 3.11
@@ -30,6 +30,9 @@ jobs:
             toolkit: 'wx'
           - os: 'macos-latest'
             toolkit: 'wx'
+          # No PySide2 wheels for macos-latest
+          - os: 'macos-latest'
+            toolkit: 'pyside2'
           # Kiva tests hanging on windows, see #1038
           - os: 'windows-latest'
             toolkit: 'pyqt5'
diff --git a/kiva/_cython_speedups.pyx b/kiva/_cython_speedups.pyx
index dc346dc76..7ee29b170 100644
--- a/kiva/_cython_speedups.pyx
+++ b/kiva/_cython_speedups.pyx
@@ -8,9 +8,12 @@
 #
 # Thanks for using Enthought open source!
 import numpy as np
-from numpy cimport uint8_t
-cimport _hit_test
 
+from numpy cimport uint8_t, import_array
+cimport cython
+from . cimport _hit_test
+
+import_array()
 
 def points_in_polygon(pts, poly_pts, use_winding=False):
     """Test whether point pairs in pts are within the polygon, poly_pts.
diff --git a/kiva/_marker_renderer.pyx b/kiva/_marker_renderer.pyx
index 62a3f35b1..6e3640782 100644
--- a/kiva/_marker_renderer.pyx
+++ b/kiva/_marker_renderer.pyx
@@ -7,11 +7,13 @@
 # is also available online at http://www.enthought.com/licenses/BSD.txt
 #
 # Thanks for using Enthought open source!
-import cython
 import numpy as np
-from numpy cimport uint8_t
 
-cimport _marker_renderer
+from numpy cimport uint8_t, import_array
+cimport cython
+from . cimport _marker_renderer
+
+import_array()
 
 ctypedef _marker_renderer.marker_renderer_base renderer_base_t
 
diff --git a/kiva/agg/src/osx/plat_support.i b/kiva/agg/src/osx/plat_support.i
index cd62243d6..378eca539 100644
--- a/kiva/agg/src/osx/plat_support.i
+++ b/kiva/agg/src/osx/plat_support.i
@@ -63,7 +63,8 @@ namespace agg24
         end_of_pix_formats
     };
 
-    %name(PixelMap) class pixel_map
+    %rename(PixelMap) pixel_map;
+    class pixel_map
     {
     public:
         ~pixel_map();
diff --git a/kiva/compatibility.py b/kiva/compatibility.py
new file mode 100644
index 000000000..107fcc76e
--- /dev/null
+++ b/kiva/compatibility.py
@@ -0,0 +1,20 @@
+# (C) Copyright 2025 Enthought, Inc., Austin, TX
+# All rights reserved.
+#
+# This software is provided without warranty under the terms of the BSD
+# license included in LICENSE.txt and may be redistributed only under
+# the conditions described in the aforementioned license. The license
+# is also available online at http://www.enthought.com/licenses/BSD.txt
+#
+# Thanks for using Enthought open source!
+""" Compatibility workaround module
+
+Module to workaround compatibility issues with different versions of
+the enable dependencies.
+
+"""
+
+try:
+    from numpy import sometrue
+except ImportError:
+    from numpy import any as sometrue
diff --git a/kiva/line_state.py b/kiva/line_state.py
index e8064d888..ec84d9e5d 100644
--- a/kiva/line_state.py
+++ b/kiva/line_state.py
@@ -1,4 +1,4 @@
-# (C) Copyright 2005-2023 Enthought, Inc., Austin, TX
+# (C) Copyright 2005-2025 Enthought, Inc., Austin, TX
 # All rights reserved.
 #
 # This software is provided without warranty under the terms of the BSD
@@ -14,8 +14,9 @@
 state (eg. Wx, SVG and PDF backends, but not Agg or QPainter).
 """
 
-from numpy import array, asarray, shape, sometrue
+from numpy import array, asarray, shape
 
+from .compatibility import sometrue
 from .constants import NO_DASH
 
 
diff --git a/kiva/quartz/ABCGI.pyx b/kiva/quartz/ABCGI.pyx
index 25ac9c1d4..08a22112c 100644
--- a/kiva/quartz/ABCGI.pyx
+++ b/kiva/quartz/ABCGI.pyx
@@ -19,7 +19,7 @@ cimport numpy
 import os
 import warnings
 
-from CTFont import default_font_info
+from .CTFont import default_font_info
 
 cdef extern from "math.h":
     double sqrt(double arg)
@@ -1479,7 +1479,7 @@ cdef class CGBitmapContext(CGContext):
             raise ValueError("bits_per_component must be 5 or 8")
 
         cdef int min_bytes
-        min_bytes = (width*bits_per_pixel + 7) / 8
+        min_bytes = (width*bits_per_pixel + 7) // 8
         if bytes_per_row < min_bytes:
             bytes_per_row = min_bytes
 
@@ -1763,7 +1763,7 @@ cdef class CGImage:
             raise ValueError("bits_per_component must be 5 or 8")
 
         cdef int min_bytes
-        min_bytes = (width*bits_per_pixel + 7) / 8
+        min_bytes = (width*bits_per_pixel + 7) // 8
         if bytes_per_row < min_bytes:
             bytes_per_row = min_bytes
 
@@ -1826,16 +1826,16 @@ cdef class CGImageFile(CGImage):
             bits_per_pixel = 8
             alpha_info = kCGImageAlphaNone
 
-        bytes_per_row = (bits_per_pixel*width + 7)/ 8
+        bytes_per_row = (bits_per_pixel*width + 7) // 8
 
         cdef char* data
         cdef char* py_data
-        cdef int dims[3]
+        cdef numpy.npy_intp dims[3]
         dims[0] = height
         dims[1] = width
-        dims[2] = bits_per_pixel/bits_per_component
+        dims[2] = bits_per_pixel // bits_per_component
 
-        self.bmp_array = numpy.PyArray_SimpleNew(3, &(dims[0]), numpy.NPY_UBYTE)
+        self.bmp_array = numpy.PyArray_SimpleNew(3, dims, numpy.NPY_UBYTE)
 
         data = self.bmp_array.data
         bs = img.tobytes()
@@ -2672,7 +2672,7 @@ cdef int bisect_left(PiecewiseLinearColorFunction self, CGFloat t):
     hi = self.num_stops
     lo = 0
     while lo < hi:
-        mid = (lo + hi)/2
+        mid = (lo + hi) // 2
         stop = self.stops[mid]
         if t < stop:
             hi = mid
@@ -2680,7 +2680,7 @@ cdef int bisect_left(PiecewiseLinearColorFunction self, CGFloat t):
             lo = mid + 1
     return lo
 
-cdef void piecewise_callback(void* obj, CGFloat* t, CGFloat* out):
+cdef void piecewise_callback(void* obj, CGFloat* t, CGFloat* out) noexcept:
    cdef int i
    cdef CGFloat eps
    cdef PiecewiseLinearColorFunction self
diff --git a/pyproject.toml b/pyproject.toml
index 6f13c370a..099dd0828 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,5 +1,5 @@
 [build-system]
-requires = ["cython<3", "oldest-supported-numpy", "setuptools", "swig", "wheel"]
+requires = ["cython", "numpy>2", "setuptools", "swig", "wheel"]
 build-backend = "setuptools.build_meta"
 
 [tool.cibuildwheel]
diff --git a/setup.py b/setup.py
index 440a7ffac..b823707d7 100644
--- a/setup.py
+++ b/setup.py
@@ -320,11 +320,6 @@ def macos_extensions():
             'kiva.quartz.ABCGI',
             sources=[
                 'kiva/quartz/ABCGI.pyx',
-                'kiva/quartz/Python.pxi',
-                'kiva/quartz/numpy.pxi',
-                'kiva/quartz/CoreFoundation.pxi',
-                'kiva/quartz/CoreGraphics.pxi',
-                'kiva/quartz/CoreText.pxi',
             ],
             extra_link_args=extra_link_args,
             include_dirs=[numpy.get_include()],
@@ -333,9 +328,6 @@ def macos_extensions():
             'kiva.quartz.CTFont',
             sources=[
                 'kiva/quartz/CTFont.pyx',
-                'kiva/quartz/CoreFoundation.pxi',
-                'kiva/quartz/CoreGraphics.pxi',
-                'kiva/quartz/CoreText.pxi',
             ],
             extra_link_args=extra_link_args,
         ),