diff --git a/jest/integration/runtime/RenderOutputMatcher.js b/jest/integration/runtime/RenderOutputMatcher.js
new file mode 100644
index 00000000000000..e76243ce9ccec0
--- /dev/null
+++ b/jest/integration/runtime/RenderOutputMatcher.js
@@ -0,0 +1,183 @@
+/**
+ * Copyright (c) Meta Platforms, Inc. and affiliates.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ *
+ * @flow strict-local
+ * @format
+ * @oncall react_native
+ */
+
+import type {RenderOutput} from 'react-native/src/private/__tests__/ReactNativeTester';
+
+import {diff} from 'jest-diff';
+import {format, plugins} from 'pretty-format';
+
+type MatchResult =
+  | {
+      pass: true,
+    }
+  | {
+      pass: false,
+      reason: string,
+    };
+
+export function toMatchRenderedOutput(
+  renderOutput: RenderOutput,
+  expected: mixed,
+): MatchResult {
+  const renderedOutput = renderOutput.getResult();
+
+  if (typeof expected === 'string') {
+    return renderedOutput === expected
+      ? {pass: true}
+      : {
+          pass: false,
+          reason: `Expected\n:${expected}\nReceived:\n${renderedOutput}`,
+        };
+  }
+
+  if (typeof expected !== 'object') {
+    return {
+      pass: false,
+      reason: 'Expected value must be a string or an object',
+    };
+  }
+
+  if (renderedOutput === '') {
+    return {
+      pass: false,
+      reason: 'Receieved empty string',
+    };
+  }
+
+  const json = convertRawJsonToJSX(JSON.parse(renderedOutput));
+  const prettyExpected = format(expected, {plugins: [plugins.ReactElement]});
+  const prettyReceived = format(json, {plugins: [plugins.ReactElement]});
+  const pass = prettyExpected === prettyReceived;
+  if (pass) {
+    return {pass: true};
+  }
+
+  return {
+    pass: false,
+    reason: diff(prettyExpected, prettyReceived) ?? 'Failed to compare outputs',
+  };
+}
+
+const REACT_ELEMENT_TYPE =
+  typeof Symbol === 'function' && Symbol.for && Symbol.for('react.element');
+
+const REACT_FRAGMENT_TYPE =
+  typeof Symbol === 'function' && Symbol.for && Symbol.for('react.fragment');
+
+type JSXJson = {
+  type: string,
+  props: mixed,
+  children: null | string | Array<JSXJson>,
+};
+
+function createJSXElementForTestComparison(
+  type: string | typeof REACT_ELEMENT_TYPE | typeof REACT_FRAGMENT_TYPE,
+  props: mixed,
+): mixed {
+  if (__DEV__) {
+    const element = {
+      $$typeof: REACT_ELEMENT_TYPE,
+      type: type,
+      key: null,
+      props: props,
+      _owner: null,
+      _store: __DEV__ ? {} : undefined,
+    };
+    // $FlowExpectedError[prop-missing]
+    Object.defineProperty(element, 'ref', {
+      enumerable: false,
+      value: null,
+    });
+    return element;
+  } else {
+    return {
+      $$typeof: REACT_ELEMENT_TYPE,
+      type: type,
+      key: null,
+      ref: null,
+      props: props,
+    };
+  }
+}
+
+function convertRawJsonToJSX(actualJSON: JSXJson | Array<JSXJson>): mixed {
+  let actualJSX;
+  if (actualJSON === null || typeof actualJSON === 'string') {
+    actualJSX = actualJSON;
+  } else if (Array.isArray(actualJSON)) {
+    if (actualJSON.length === 0) {
+      actualJSX = null;
+    } else if (actualJSON.length === 1) {
+      actualJSX = jsonChildToJSXChild(actualJSON[0]);
+    } else {
+      const actualJSXChildren = jsonChildrenToJSXChildren(actualJSON);
+      if (actualJSXChildren === null || typeof actualJSXChildren === 'string') {
+        actualJSX = actualJSXChildren;
+      } else {
+        actualJSX = createJSXElementForTestComparison(REACT_FRAGMENT_TYPE, {
+          children: actualJSXChildren,
+        });
+      }
+    }
+  } else {
+    actualJSX = jsonChildToJSXChild(actualJSON);
+  }
+
+  return actualJSX;
+}
+
+function rnTypeToTestType(type: string): string | typeof REACT_FRAGMENT_TYPE {
+  if (type === 'Fragment') {
+    return REACT_FRAGMENT_TYPE;
+  }
+
+  return `rn-${type.substring(0, 1).toLowerCase() + type.substring(1)}`;
+}
+
+function jsonChildToJSXChild(jsonChild: null | string | JSXJson): mixed {
+  if (jsonChild === null || typeof jsonChild === 'string') {
+    return jsonChild;
+  } else {
+    const jsxChildren = jsonChildrenToJSXChildren(jsonChild.children);
+    const type = rnTypeToTestType(jsonChild.type);
+    return createJSXElementForTestComparison(
+      type,
+      jsxChildren == null
+        ? jsonChild.props
+        : {...jsonChild.props, children: jsxChildren},
+    );
+  }
+}
+
+function jsonChildrenToJSXChildren(jsonChildren: JSXJson['children']) {
+  if (jsonChildren != null) {
+    if (jsonChildren.length === 1) {
+      return jsonChildToJSXChild(jsonChildren[0]);
+    } else if (jsonChildren.length > 1) {
+      const jsxChildren = [];
+      let allJSXChildrenAreStrings = true;
+      let jsxChildrenString = '';
+      for (let i = 0; i < jsonChildren.length; i++) {
+        const jsxChild = jsonChildToJSXChild(jsonChildren[i]);
+        jsxChildren.push(jsxChild);
+        if (allJSXChildrenAreStrings) {
+          if (typeof jsxChild === 'string') {
+            jsxChildrenString += jsxChild;
+          } else if (jsxChild !== null) {
+            allJSXChildrenAreStrings = false;
+          }
+        }
+      }
+      return allJSXChildrenAreStrings ? jsxChildrenString : jsxChildren;
+    }
+  }
+  return null;
+}
diff --git a/jest/integration/runtime/setup.js b/jest/integration/runtime/setup.js
index 775c88cfebe182..8ed74dfc5a2ff6 100644
--- a/jest/integration/runtime/setup.js
+++ b/jest/integration/runtime/setup.js
@@ -9,8 +9,12 @@
  * @oncall react_native
  */
 
+import type {RenderOutput} from 'react-native/src/private/__tests__/ReactNativeTester';
+
+import {toMatchRenderedOutput} from './RenderOutputMatcher';
 import deepEqual from 'deep-equal';
 import nullthrows from 'nullthrows';
+import {maybeRenderOutput} from 'react-native/src/private/__tests__/ReactNativeTester';
 
 export type TestCaseResult = {
   ancestorTitles: Array<string>,
@@ -221,6 +225,11 @@ class Expect {
   }
 
   toEqual(expected: mixed): void {
+    const renderOutput = maybeRenderOutput(this.#received);
+    if (renderOutput) {
+      return this.#toMatchRenderedOutput(renderOutput, expected);
+    }
+
     const pass = deepEqual(this.#received, expected, {strict: true});
     if (!this.#isExpectedResult(pass)) {
       throw new ErrorWithCustomBlame(
@@ -230,6 +239,11 @@ class Expect {
   }
 
   toBe(expected: mixed): void {
+    const renderOutput = maybeRenderOutput(this.#received);
+    if (renderOutput) {
+      return this.#toMatchRenderedOutput(renderOutput, expected);
+    }
+
     const pass = this.#received === expected;
     if (!this.#isExpectedResult(pass)) {
       throw new ErrorWithCustomBlame(
@@ -307,6 +321,15 @@ class Expect {
     }
   }
 
+  #toMatchRenderedOutput(renderOutput: RenderOutput, expected: mixed): void {
+    const result = toMatchRenderedOutput(renderOutput, expected);
+    if (!this.#isExpectedResult(result.pass)) {
+      throw new Error(
+        `Expected${this.#maybeNotLabel()} to match rendered output${result.pass ? '' : `:\n${result.reason}`}`,
+      );
+    }
+  }
+
   #isExpectedResult(pass: boolean): boolean {
     return this.#isNot ? !pass : pass;
   }